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mw-list-item"><a href="https://cy.wikipedia.org/wiki/Paricalcitol" title="Paricalcitol – Welsh" lang="cy" hreflang="cy" data-title="Paricalcitol" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%D8%A7%D8%B1%DB%8C%DA%A9%D9%84%D8%B3%DB%8C%D8%AA%D9%88%D9%84" title="پاریکلسیتول – Persian" lang="fa" hreflang="fa" data-title="پاریکلسیتول" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Paricalcitol" title="Paricalcitol – French" lang="fr" hreflang="fr" data-title="Paricalcitol" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%91%E3%83%AA%E3%82%AB%E3%83%AB%E3%82%B7%E3%83%88%E3%83%BC%E3%83%AB" title="パリカルシトール – Japanese" lang="ja" hreflang="ja" data-title="パリカルシトール" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%AA%E0%AC%BE%E0%AC%B0%E0%AC%BF%E0%AC%95%E0%AC%BE%E0%AC%B2%E0%AC%B8%E0%AC%BF%E0%AC%9F%E0%AD%8B%E0%AC%B2" title="ପାରିକାଲସିଟୋଲ – Odia" lang="or" hreflang="or" data-title="ପାରିକାଲସିଟୋଲ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Paricalcitol" title="Paricalcitol – Romanian" lang="ro" hreflang="ro" data-title="Paricalcitol" data-language-autonym="Română" 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class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Paricalcitol">Paricalcitol</span></caption><tbody><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Paricalcitol.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Paricalcitol.svg/200px-Paricalcitol.svg.png" decoding="async" width="200" height="177" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Paricalcitol.svg/300px-Paricalcitol.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Paricalcitol.svg/400px-Paricalcitol.svg.png 2x" data-file-width="512" data-file-height="452" /></a></span></td></tr><tr><td colspan="2" class="infobox-image notheme" style="background-color: #f8f9fa;"><span typeof="mw:File"><a href="/wiki/File:Paricalcitol3Dan.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/Paricalcitol3Dan.gif/200px-Paricalcitol3Dan.gif" decoding="async" width="200" height="200" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/9/90/Paricalcitol3Dan.gif 1.5x" data-file-width="256" data-file-height="256" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Zemplar</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data"><small>(1<i>R</i>,3<i>S</i>)-5-[2-[(1<i>R</i>,3a<i>R</i>,7a<i>S</i>)-1-[(2<i>R</i>,5<i>S</i>)-6-hydroxy-5,6-dimethyl-3<i>E</i>-hepten-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1<i>H</i>-inden-4-ylidene]ethylidene]-cyclohexane-1,3-diol</small></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/paricalcitol.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a682335.html">a682335</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> C</li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data">Oral, Intravenous</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_H05" title="ATC code H05">H05BX02</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=H05BX02">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)</li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a></li> <li><small><abbr class="country-name" title="United Kingdom">UK</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)</li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a></li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">72%<sup id="cite_ref-MSR_1-0" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">99.8%<sup id="cite_ref-MSR_1-1" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data"><a href="/wiki/Hepatic" class="mw-redirect" title="Hepatic">Hepatic</a><sup id="cite_ref-MSR_1-4" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">14-20 hours<sup id="cite_ref-MSR_1-2" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data">Faeces (74%), urine (16%)<sup id="cite_ref-MSR_1-3" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(1<i>R</i>,3<i>R</i>,7<i>E</i>,17β)-17-[(1<i>R</i>,2<i>E</i>,4<i>S</i>)-5-hydroxy-1,4,5-trimethylhex-2-en-1-yl]-9,10-secoestra-5,7-diene-1,3-diol</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=131918-61-1">131918-61-1</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/5281104">5281104</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2791">2791</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00910">DB00910</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.4444552.html">4444552</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/6702D36OG5">6702D36OG5</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D00930">D00930</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7931">CHEBI:7931</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL1200622">ChEMBL1200622</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID4048640">DTXSID4048640</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q155746#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.184.862">100.184.862</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q155746#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>27</sub><span title="Hydrogen">H</span><sub>44</sub><span title="Oxygen">O</span><sub>3</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002416646000000000♠"></span>416.646</span> g·mol<sup>−1</sup></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:BPKAHTKRCLCHEA-UBFJEZKGSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold"> <sup><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup> <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a></span><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488"><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=445909355&page2=Paricalcitol">(verify)</a></span></span></td></tr></tbody></table> <p><b>Paricalcitol</b> (chemically it is <b>19-nor-1,25-(OH)<sub>2</sub>-vitamin D<sub>2</sub></b>. Marketed by <a href="/wiki/Abbott_Laboratories" title="Abbott Laboratories">Abbott Laboratories</a> under the trade name <b>Zemplar</b>) is a <a href="/wiki/Pharmaceutical_drug" class="mw-redirect" title="Pharmaceutical drug">drug</a> used for the prevention and treatment of <a href="/wiki/Secondary_hyperparathyroidism" title="Secondary hyperparathyroidism">secondary hyperparathyroidism</a> (excessive secretion of <a href="/wiki/Parathyroid_hormone" title="Parathyroid hormone">parathyroid hormone</a>) associated with <a href="/wiki/Chronic_kidney_failure" class="mw-redirect" title="Chronic kidney failure">chronic kidney failure</a>. It is an <a href="/wiki/Analog_(chemistry)" class="mw-redirect" title="Analog (chemistry)">analog</a> of 1,25-dihydroxyergocalciferol, the active form of <a href="/wiki/Vitamin_D2" class="mw-redirect" title="Vitamin D2">vitamin D<sub>2</sub></a> (ergocalciferol). </p><p>It was patented in 1989 and approved for medical use in 1998.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Its primary use in medicine is in the treatment of secondary <a href="/wiki/Hyperparathyroidism" title="Hyperparathyroidism">hyperparathyroidism</a> associated with <a href="/wiki/Chronic_kidney_disease" title="Chronic kidney disease">chronic kidney disease</a>.<sup id="cite_ref-AMH_3-0" class="reference"><a href="#cite_note-AMH-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> However a 2016 systematic review did not find evidence sufficient to demonstrate an advantage of paricalcitol over non-selective vitamin D derivatives for this indication.<sup id="cite_ref-Cai_2016_4-0" class="reference"><a href="#cite_note-Cai_2016-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=2" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><b>Adverse effects by frequency:</b><sup id="cite_ref-MSR_1-5" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AMH_3-1" class="reference"><a href="#cite_note-AMH-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DM_5-0" class="reference"><a href="#cite_note-DM-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EMC_6-0" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><br /> </p><p><b>Very common (>10% frequency):</b> </p> <ul><li>Nausea</li></ul> <p><b>Common (1-10% frequency):</b> </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 18em;"> <ul><li>Diarrhoea<sup>†</sup></li> <li><a href="/wiki/Oedema" class="mw-redirect" title="Oedema">Oedema</a></li> <li>Allergic reaction</li> <li><a href="/wiki/Arthritis" title="Arthritis">Arthritis</a></li> <li>Dizziness<sup>†</sup></li> <li>Stomach discomfort<sup>‡</sup></li> <li><a href="/wiki/Gastroesophageal_reflux_disease" title="Gastroesophageal reflux disease">Gastroesophageal reflux disease</a><sup>†</sup></li> <li><a href="/wiki/Acne" title="Acne">Acne</a><sup>†</sup></li> <li><a href="/wiki/Hypercalcaemia" title="Hypercalcaemia">Hypercalcaemia</a><sup>†</sup></li> <li><a href="/wiki/Hypocalcaemia" class="mw-redirect" title="Hypocalcaemia">Hypocalcaemia</a><sup>†</sup></li> <li><a href="/wiki/Hyperphosphataemia" class="mw-redirect" title="Hyperphosphataemia">Hyperphosphataemia</a></li> <li>Decreased appetite<sup>†</sup></li> <li>Headache</li> <li>Breast tenderness<sup>†</sup></li> <li>Taste changes</li> <li><a href="/wiki/Hypoparathyroidism" title="Hypoparathyroidism">Hypoparathyroidism</a></li> <li>Vertigo</li> <li>Rash<sup>‡</sup></li></ul> </div> <p><b>Uncommon (0.1-1% frequency):</b> </p> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 18em;"> <ul><li>Abnormal hepatic enzymes<sup>‡</sup></li> <li>Constipation<sup>‡</sup></li> <li>Dry mouth<sup>‡</sup></li> <li><a href="/wiki/Pruritus" class="mw-redirect" title="Pruritus">Itchiness</a><sup>‡</sup></li> <li><a href="/wiki/Urticaria" class="mw-redirect" title="Urticaria">Hives</a></li> <li>Hypersensitivity<sup>‡</sup></li> <li>Muscle spasms<sup>‡</sup></li> <li>Bleeding time prolonged</li> <li>Aspartate aminotransferase increased</li> <li>Laboratory test abnormal</li> <li>Weight loss</li> <li>Elevated blood creatinine</li> <li>Cardiac arrest</li> <li>Arrhythmia</li> <li>Atrial flutter</li> <li><a href="/wiki/Anaemia" class="mw-redirect" title="Anaemia">Anaemia</a></li> <li><a href="/wiki/Leucopenia" class="mw-redirect" title="Leucopenia">Leucopenia</a></li> <li>Lymphadenopathy</li> <li>Coma</li> <li><a href="/wiki/Cerebrovascular_accident" class="mw-redirect" title="Cerebrovascular accident">Stroke</a></li> <li><a href="/wiki/Transient_ischemic_attack" title="Transient ischemic attack">Transient ischemic attack</a></li> <li><a href="/wiki/Vasovagal_syncope" class="mw-redirect" title="Vasovagal syncope">Fainting</a></li> <li><a href="/wiki/Myoclonus" title="Myoclonus">Myoclonus</a></li> <li><a href="/wiki/Hypoaesthesia" class="mw-redirect" title="Hypoaesthesia">Hypoaesthesia</a></li> <li><a href="/wiki/Paraesthesia" class="mw-redirect" title="Paraesthesia">Paraesthesia</a></li> <li><a href="/wiki/Glaucoma" title="Glaucoma">Glaucoma</a></li> <li><a href="/wiki/Conjunctivitis" title="Conjunctivitis">Conjunctivitis</a></li> <li>Ear disorder</li> <li>Pulmonary oedema</li> <li>Asthma</li> <li><a href="/wiki/Dyspnoea" class="mw-redirect" title="Dyspnoea">Shortness of breath</a></li> <li><a href="/wiki/Epistaxis" class="mw-redirect" title="Epistaxis">Nose bleed</a></li> <li>Cough</li> <li>Rectal haemhorrhage</li> <li><a href="/wiki/Colitis" title="Colitis">Colitis</a></li> <li><a href="/wiki/Gastritis" title="Gastritis">Gastritis</a></li> <li><a href="/wiki/Dyspepsia" class="mw-redirect" title="Dyspepsia">Indigestion</a></li> <li><a href="/wiki/Dysphagia" title="Dysphagia">Difficulty swallowing</a></li> <li>Gastrointestinal disorder</li> <li>Gastrointestinal haemorrhage</li> <li>Bullous dermatitis</li> <li><a href="/wiki/Alopecia" class="mw-redirect" title="Alopecia">Hair loss</a></li> <li><a href="/wiki/Hirsutism" title="Hirsutism">Hirsutism</a></li> <li><a href="/wiki/Hyperhidrosis" title="Hyperhidrosis">Hyperhidrosis</a></li> <li><a href="/wiki/Arthralgia" title="Arthralgia">Joint pain</a></li> <li>Joint stiffness</li> <li>Back pain</li> <li>Muscle twitching</li> <li><a href="/wiki/Myalgia" title="Myalgia">Muscle aches</a></li> <li><a href="/wiki/Hyperparathyroidism" title="Hyperparathyroidism">Hyperparathyroidism</a></li> <li><a href="/wiki/Hyperkalaemia" class="mw-redirect" title="Hyperkalaemia">Hyperkalaemia</a></li> <li><a href="/wiki/Hypocalcemia" title="Hypocalcemia">Hypocalcemia</a></li> <li><a href="/wiki/Breast_cancer" title="Breast cancer">Breast cancer</a></li> <li><a href="/wiki/Sepsis" title="Sepsis">Sepsis</a></li> <li><a href="/wiki/Pneumonia" title="Pneumonia">Pneumonia</a></li> <li>Infection</li> <li><a href="/wiki/Pharyngitis" title="Pharyngitis">Pharyngitis</a></li> <li>Vaginal infection</li> <li>Influenza</li> <li><a href="/wiki/Hypertension" title="Hypertension">High blood pressure</a></li> <li><a href="/wiki/Hypotension" title="Hypotension">Hypotension</a></li> <li>Gait disturbance</li> <li>Injection site pain</li> <li><a href="/wiki/Pyrexia" class="mw-redirect" title="Pyrexia">Fever</a></li> <li>Chest pain</li> <li>Condition aggravated</li> <li><a href="/wiki/Asthenia" class="mw-redirect" title="Asthenia">Muscle weakness</a></li> <li><a href="/wiki/Malaise" title="Malaise">Malaise</a></li> <li>Thirst</li> <li>Breast pain</li> <li><a href="/wiki/Erectile_dysfunction" title="Erectile dysfunction">Impotence</a></li> <li>Confusional state</li> <li>Delirium</li> <li>Depersonalization</li> <li>Agitation</li> <li>Insomnia</li> <li>Nervousness</li></ul> </div> <p><sup>‡</sup> These are adverse effects only seen in patients with grade 3 or 4 chronic kidney disease. <sup>†</sup> These are adverse effects only seen in patients with grade 5 chronic kidney disease. </p> <div class="mw-heading mw-heading2"><h2 id="Contraindications">Contraindications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=3" title="Edit section: Contraindications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Contraindications include:<sup id="cite_ref-EMC_6-1" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Hypervitaminosis_D" class="mw-redirect" title="Hypervitaminosis D">Vitamin D intoxication</a></li> <li><a href="/wiki/Hypercalcaemia" title="Hypercalcaemia">Hypercalcaemia</a></li> <li>Hypersensitivity to paricalcitol or any of its excipients</li></ul> <p>whereas cautions include:<sup id="cite_ref-MSR_1-6" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <ul><li>Impaired liver function</li> <li>It is also advised that physicians regularly monitor their patients' <a href="/wiki/Calcium" title="Calcium">calcium</a> and <a href="/wiki/Phosphorus" title="Phosphorus">phosphorus</a> levels.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=4" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Drugs that may interact with paricalcitol include:<sup id="cite_ref-MSR_1-7" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EMC_6-2" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 30em;"> <ul><li><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a>, as it may interfere with paricalcitol's metabolism in the liver.</li> <li><a href="/wiki/Digitoxin" title="Digitoxin">Digitoxin</a>, hypercalcaemia due to any cause can exacerbate the toxicity of digitoxin.</li> <li><a href="/wiki/Thiazide" title="Thiazide">Thiazide</a> diuretics or calcium supplements as <a href="/wiki/Hypercalcaemia" title="Hypercalcaemia">hypercalcaemia</a> may be induced by this combination</li> <li><a href="/wiki/Magnesium" title="Magnesium">Magnesium</a>-containing products such as <a href="/wiki/Antacids" class="mw-redirect" title="Antacids">antacids</a> may increase the risk of <a href="/wiki/Hypermagnesemia" title="Hypermagnesemia">hypermagnesemia</a>.</li> <li><a href="/wiki/Aluminium" title="Aluminium">Aluminium</a>-containing products such as antacids may increase the risk of <a href="/wiki/Aluminium_toxicity" class="mw-redirect" title="Aluminium toxicity">aluminium toxicity</a>.</li> <li>Drugs that interfere with the absorption of fat-soluble vitamins, such as <a href="/wiki/Cholestyramine" class="mw-redirect" title="Cholestyramine">cholestyramine</a> may interfere with the absorption of paricalcitol.</li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="Overdose">Overdose</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=5" title="Edit section: Overdose"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Electrolyte abnormalities (e.g. <a href="/wiki/Hypercalcaemia" title="Hypercalcaemia">hypercalcaemia</a> and <a href="/wiki/Hyperphosphataemia" class="mw-redirect" title="Hyperphosphataemia">hyperphosphataemia</a>) are common overdose symptoms.<sup id="cite_ref-EMC_6-3" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Treatment is mostly supportive, with particular attention being paid to correcting electrolyte anomalies and reducing intake of calcium in both the form of supplementation and diet.<sup id="cite_ref-EMC_6-4" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> As it is so heavily bound to plasma proteins <a href="/wiki/Haemodialysis" class="mw-redirect" title="Haemodialysis">haemodialysis</a> is unlikely to be helpful in cases of overdose.<sup id="cite_ref-EMC_6-5" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Early symptoms of overdose can include:<sup id="cite_ref-EMC_6-6" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 18em;"> <ul><li>Weakness</li> <li>Headache</li> <li>Somnolence</li> <li>Nausea</li> <li>Vomiting</li> <li>Dry mouth</li> <li>Constipation</li> <li>Muscle pain</li> <li>Bone pain</li> <li>Metallic taste in the mouth.</li></ul> </div> <p>It is worth noting, however, that may of these symptoms are also indicative of kidney failure and hence may be masked by the patient's condition.<sup id="cite_ref-EMC_6-7" class="reference"><a href="#cite_note-EMC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Late symptoms of overdose include: </p> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 18em;"> <ul><li><a href="/wiki/Anorexia_(symptom)" title="Anorexia (symptom)">Loss of appetite</a></li> <li>Weight loss</li> <li><a href="/wiki/Conjunctivitis" title="Conjunctivitis">Conjunctivitis</a> (calcific)</li> <li><a href="/wiki/Pancreatitis" title="Pancreatitis">Pancreatitis</a></li> <li>Photophobia</li> <li>Rhinorrhoea</li> <li>Pruritus</li> <li>Hyperthermia</li> <li>Decreased libido</li> <li>Elevated BUN</li> <li>Hypercholesterolaemia</li> <li>Elevated AST and ALT</li> <li>Ectopic calcification</li> <li>Hypertension</li> <li>Cardiac arrhythmias</li> <li>Somnolence</li> <li>Death</li> <li>Psychosis (rare)</li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="Mechanism_of_action">Mechanism of action</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=6" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:Paricalcitol_structure.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/42/Paricalcitol_structure.svg/220px-Paricalcitol_structure.svg.png" decoding="async" width="220" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/42/Paricalcitol_structure.svg/330px-Paricalcitol_structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/42/Paricalcitol_structure.svg/440px-Paricalcitol_structure.svg.png 2x" data-file-width="303" data-file-height="153" /></a><figcaption>3D structure of paricalcitol</figcaption></figure><div style="clear:left;" class=""></div> <p>Like 1,25-dihydroxyergocalciferol, paricalcitol acts as an <a href="/wiki/Agonist" title="Agonist">agonist</a> at the <a href="/wiki/Vitamin_D_receptor" title="Vitamin D receptor">vitamin D receptor</a> and thereby lowers <a href="/wiki/Parathyroid_hormone" title="Parathyroid hormone">parathyroid hormone</a> levels in the blood.<sup id="cite_ref-MSR_1-8" class="reference"><a href="#cite_note-MSR-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacokinetics">Pharmacokinetics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=7" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The plasma concentration of paricalcitol decreases rapidly and log-linearly within two hours after initial intravenous administration. Therefore, it is not expected to accumulate with multiple dosing, since paricalcitol is usually given no more frequently than every other day (3 times per week).<sup id="cite_ref-Rxlist_7-0" class="reference"><a href="#cite_note-Rxlist-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-paricalcitol_PI_8-0" class="reference"><a href="#cite_note-paricalcitol_PI-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paricalcitol&action=edit&section=8" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-MSR-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-MSR_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-MSR_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-MSR_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-MSR_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-MSR_1-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-MSR_1-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-MSR_1-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-MSR_1-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-MSR_1-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://reference.medscape.com/drug/zemplar-paricalcitol-342830#showall">"Zemplar (paricalcitol) dosing, indications, interactions, adverse effects, and more"</a>. <i>Medscape Reference</i>. WebMD<span class="reference-accessdate">. Retrieved <span class="nowrap">26 January</span> 2014</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Medscape+Reference&rft.atitle=Zemplar+%28paricalcitol%29+dosing%2C+indications%2C+interactions%2C+adverse+effects%2C+and+more&rft_id=http%3A%2F%2Freference.medscape.com%2Fdrug%2Fzemplar-paricalcitol-342830%23showall&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFischerGanellin2006" class="citation book cs1">Fischer J, Ganellin CR (2006). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA452"><i>Analogue-based Drug Discovery</i></a>. John Wiley & Sons. p. 452. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783527607495" title="Special:BookSources/9783527607495"><bdi>9783527607495</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Analogue-based+Drug+Discovery&rft.pages=452&rft.pub=John+Wiley+%26+Sons&rft.date=2006&rft.isbn=9783527607495&rft.aulast=Fischer&rft.aufirst=J&rft.au=Ganellin%2C+CR&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DFjKfqkaKkAAC%26pg%3DPA452&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> <li id="cite_note-AMH-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-AMH_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-AMH_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRossi2013" class="citation book cs1">Rossi S, ed. (2013). <i>Australian Medicines Handbook</i> (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-9805790-9-3" title="Special:BookSources/978-0-9805790-9-3"><bdi>978-0-9805790-9-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Australian+Medicines+Handbook&rft.place=Adelaide&rft.edition=2013&rft.pub=The+Australian+Medicines+Handbook+Unit+Trust&rft.date=2013&rft.isbn=978-0-9805790-9-3&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> <li id="cite_note-Cai_2016-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-Cai_2016_4-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCaiTangQinJi2016" class="citation journal cs1">Cai P, Tang X, Qin W, Ji L, Li Z (April 2016). "Comparison between paricalcitol and active non-selective vitamin D receptor activator for secondary hyperparathyroidism in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials". <i>International Urology and Nephrology</i>. <b>48</b> (4): 571–84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs11255-015-1195-6">10.1007/s11255-015-1195-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26748501">26748501</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:10633197">10633197</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Urology+and+Nephrology&rft.atitle=Comparison+between+paricalcitol+and+active+non-selective+vitamin+D+receptor+activator+for+secondary+hyperparathyroidism+in+chronic+kidney+disease%3A+a+systematic+review+and+meta-analysis+of+randomized+controlled+trials&rft.volume=48&rft.issue=4&rft.pages=571-84&rft.date=2016-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A10633197%23id-name%3DS2CID&rft_id=info%3Apmid%2F26748501&rft_id=info%3Adoi%2F10.1007%2Fs11255-015-1195-6&rft.aulast=Cai&rft.aufirst=P&rft.au=Tang%2C+X&rft.au=Qin%2C+W&rft.au=Ji%2C+L&rft.au=Li%2C+Z&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> <li id="cite_note-DM-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-DM_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac3028be-d563-4b0c-86d3-5a7e1c92758c">"PARICALCITOL capsule, liquid filled"</a>. Banner Pharmacaps. 1 December 2014 – via DailyMed.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=PARICALCITOL+capsule%2C+liquid+filled&rft.pub=Banner+Pharmacaps&rft.date=2014-12-01&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3Dac3028be-d563-4b0c-86d3-5a7e1c92758c&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> <li id="cite_note-EMC-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-EMC_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-EMC_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-EMC_6-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-EMC_6-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-EMC_6-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-EMC_6-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-EMC_6-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-EMC_6-7"><sup><i><b>h</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.medicines.org.uk/emc/medicine/20464/SPC/Zemplar+Soft+Capsules+1+mcg/">"Zemplar Soft Capsules 1 mcg - Summary of Product Characteristics"</a>. <i>electronic Medicines Compendium</i>. AbbVie Limited. 15 April 2013<span class="reference-accessdate">. Retrieved <span class="nowrap">26 January</span> 2014</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=electronic+Medicines+Compendium&rft.atitle=Zemplar+Soft+Capsules+1+mcg+-+Summary+of+Product+Characteristics&rft.date=2013-04-15&rft_id=http%3A%2F%2Fwww.medicines.org.uk%2Femc%2Fmedicine%2F20464%2FSPC%2FZemplar%2BSoft%2BCapsules%2B1%2Bmcg%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> <li id="cite_note-Rxlist-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-Rxlist_7-0">^</a></b></span> <span class="reference-text">Rxlist: <a rel="nofollow" class="external text" href="http://www.rxlist.com/zemplar-drug.htm">Zemplar</a></span> </li> <li id="cite_note-paricalcitol_PI-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-paricalcitol_PI_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.zemplar.com">"Zemplar (paricalcitol) [prescribing information]"</a>. North Chicago, IL: AbbVie Inc. October 1, 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">December 12,</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Zemplar+%28paricalcitol%29+%5Bprescribing+information%5D&rft.place=North+Chicago%2C+IL&rft.pub=AbbVie+Inc.&rft.date=2015-10-01&rft_id=http%3A%2F%2Fwww.zemplar.com&rfr_id=info%3Asid%2Fen.wikipedia.org%3AParicalcitol" class="Z3988"></span></span> </li> </ol></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol 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title="Β-Carotene">β-Carotene</a></li> <li><a href="/wiki/Retinol" title="Retinol">Retinol</a><sup>#</sup></li> <li><a href="/wiki/Tretinoin" title="Tretinoin">Tretinoin</a><sup>#</sup></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vitamin_D" title="Vitamin D">D</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>D<sub>2</sub> <ul><li><a href="/wiki/Ergosterol" title="Ergosterol">Ergosterol</a></li> <li><a href="/wiki/Ergocalciferol" title="Ergocalciferol">Ergocalciferol</a><sup>#</sup></li></ul></li> <li>D<sub>3</sub> <ul><li><a href="/wiki/7-Dehydrocholesterol" title="7-Dehydrocholesterol">7-Dehydrocholesterol</a></li> <li><a href="/wiki/Previtamin_D3" title="Previtamin D3">Previtamin D<sub>3</sub></a></li> <li><a href="/wiki/Cholecalciferol" title="Cholecalciferol">Cholecalciferol</a><sup>#</sup></li> <li><a href="/wiki/Calcifediol" title="Calcifediol">25-hydroxycholecalciferol</a></li> <li><a href="/wiki/Calcitriol" title="Calcitriol">Calcitriol (1,25-dihydroxycholecalciferol)</a></li> <li><a href="/wiki/Calcitroic_acid" title="Calcitroic acid">Calcitroic acid</a></li></ul></li> <li>D<sub>4</sub> <ul><li><a href="/wiki/22-Dihydroergocalciferol" title="22-Dihydroergocalciferol">Dihydroergocalciferol</a></li></ul></li> <li><a href="/wiki/Vitamin_D5" title="Vitamin D5">D<sub>5</sub></a></li> <li>D analogues <ul><li><a href="/wiki/Alfacalcidol" title="Alfacalcidol">Alfacalcidol</a></li> <li><a href="/wiki/Dihydrotachysterol" title="Dihydrotachysterol">Dihydrotachysterol</a></li> <li><a href="/wiki/Calcipotriol" title="Calcipotriol">Calcipotriol</a></li> <li><a href="/wiki/Tacalcitol" title="Tacalcitol">Tacalcitol</a></li> <li><a class="mw-selflink selflink">Paricalcitol</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vitamin_E" title="Vitamin E">E</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tocopherol" title="Tocopherol">Tocopherol</a> <ul><li><a href="/wiki/%CE%91-Tocopherol" title="Α-Tocopherol">Alpha</a></li> <li><a href="/wiki/%CE%92-Tocopherol" title="Β-Tocopherol">Beta</a></li> <li><a href="/wiki/%CE%93-Tocopherol" title="Γ-Tocopherol">Gamma</a></li> <li><a href="/wiki/%CE%94-Tocopherol" title="Δ-Tocopherol">Delta</a></li></ul></li> <li><a href="/wiki/Tocotrienol" title="Tocotrienol">Tocotrienol</a> <ul><li><a href="/wiki/%CE%91-Tocotrienol" title="Α-Tocotrienol">Alpha</a></li> <li><a href="/wiki/%CE%92-Tocotrienol" title="Β-Tocotrienol">Beta</a></li> <li><a href="/wiki/%CE%93-Tocotrienol" title="Γ-Tocotrienol">Gamma</a></li> <li>Delta</li></ul></li> <li><a href="/wiki/Tocofersolan" title="Tocofersolan">Tocofersolan</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vitamin_K" title="Vitamin K">K</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/1,4-Naphthoquinone" title="1,4-Naphthoquinone">Naphthoquinone</a></li> <li><a href="/wiki/Phytomenadione" title="Phytomenadione">Phylloquinone (K<sub>1</sub>)</a><sup>#</sup></li> <li><a href="/wiki/Vitamin_K2" title="Vitamin K2">Menaquinones (K<sub>2</sub>)</a></li> <li><a href="/wiki/Menadione" title="Menadione">Menadione (K<sub>3</sub>)</a><sup>‡</sup></li> <li><a href="/wiki/Vitamin_K4" class="mw-redirect" title="Vitamin K4">Various (K<sub>4</sub>)</a></li> <li><a href="/wiki/4-Amino-2-methyl-1-naphthol" title="4-Amino-2-methyl-1-naphthol">4-Amino-2-methyl-1-naphthol (K<sub>5</sub>)</a><sup>‡</sup></li> <li><a href="/wiki/2-Methylnaphthalene-1,4-diamine" title="2-Methylnaphthalene-1,4-diamine">2-Methylnaphthalene-1,4-diamine (K<sub>6</sub>)</a></li> <li><a href="/wiki/4-Amino-3-methyl-1-naphthol" title="4-Amino-3-methyl-1-naphthol">4-Amino-3-methyl-1-naphthol (K<sub>7</sub>)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Water <br />soluble</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/B_vitamins" title="B vitamins">B</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>B<sub>1</sub> <ul><li><a href="/wiki/Thiamine" title="Thiamine">Thiamine</a><sup>#</sup></li></ul></li> <li><a href="/wiki/Vitamin_B1_analogues" title="Vitamin B1 analogues">B<sub>1</sub> analogues</a> <ul><li><a href="/wiki/Acefurtiamine" title="Acefurtiamine">Acefurtiamine</a></li> <li><a href="/wiki/Allithiamine" title="Allithiamine">Allithiamine</a></li> <li><a href="/wiki/Benfotiamine" title="Benfotiamine">Benfotiamine</a></li> <li><a href="/wiki/Fursultiamine" title="Fursultiamine">Fursultiamine</a></li> <li><a href="/wiki/Octotiamine" title="Octotiamine">Octotiamine</a></li> <li><a href="/wiki/Prosultiamine" title="Prosultiamine">Prosultiamine</a></li> <li><a href="/wiki/Sulbutiamine" title="Sulbutiamine">Sulbutiamine</a></li></ul></li> <li>B<sub>2</sub> <ul><li><a href="/wiki/Riboflavin" title="Riboflavin">Riboflavin</a><sup>#</sup></li></ul></li> <li><a href="/wiki/Vitamin_B3" title="Vitamin B3">B<sub>3</sub></a> <ul><li><a href="/wiki/Niacin" title="Niacin">Niacin</a></li> <li><a href="/wiki/Nicotinamide" title="Nicotinamide">Niacinamide</a><sup>#</sup></li></ul></li> <li>B<sub>5</sub> <ul><li><a href="/wiki/Pantothenic_acid" title="Pantothenic acid">Pantothenic acid</a></li> <li><a href="/wiki/Panthenol" title="Panthenol">Dexpanthenol</a></li> <li><a href="/wiki/Pantethine" title="Pantethine">Pantethine</a></li></ul></li> <li><a href="/wiki/Vitamin_B6" title="Vitamin B6">B<sub>6</sub></a> <ul><li><a href="/wiki/Pyridoxine" title="Pyridoxine">Pyridoxine</a><sup>#</sup>, <a href="/wiki/Pyridoxal_phosphate" title="Pyridoxal phosphate">Pyridoxal phosphate</a></li> <li><a href="/wiki/Pyridoxamine" title="Pyridoxamine">Pyridoxamine</a></li> <li><a href="/wiki/Pyritinol" title="Pyritinol">Pyritinol</a></li></ul></li> <li>B<sub>7</sub> <ul><li><a href="/wiki/Biotin" title="Biotin">Biotin</a></li></ul></li> <li>B<sub>9</sub> <ul><li><a href="/wiki/Folate" title="Folate">Folic acid</a><sup>#</sup></li> <li><a href="/wiki/Dihydrofolic_acid" title="Dihydrofolic acid">Dihydrofolic acid</a></li> <li><a href="/wiki/Folinic_acid" title="Folinic acid">Folinic acid</a></li> <li><a href="/wiki/Levomefolic_acid" title="Levomefolic acid">Levomefolic acid</a></li></ul></li> <li><a href="/wiki/Vitamin_B12" title="Vitamin B12">B<sub>12</sub></a> <ul><li><a href="/wiki/Adenosylcobalamin" title="Adenosylcobalamin">Adenosylcobalamin</a></li> <li><a href="/wiki/Cyanocobalamin" title="Cyanocobalamin">Cyanocobalamin</a></li> <li><a href="/wiki/Hydroxocobalamin" title="Hydroxocobalamin">Hydroxocobalamin</a><sup>#</sup></li> <li><a href="/wiki/Methylcobalamin" title="Methylcobalamin">Methylcobalamin</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Vitamin_C" title="Vitamin C">C</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vitamin_C" title="Vitamin C">Ascorbic acid</a><sup>#</sup></li> <li><a href="/wiki/Dehydroascorbic_acid" title="Dehydroascorbic acid">Dehydroascorbic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Combinations</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Multivitamin" title="Multivitamin">Multivitamins</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Calcium_homeostasis_(H05)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Calcium_homeostasis" title="Template:Calcium homeostasis"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Calcium_homeostasis" title="Template talk:Calcium homeostasis"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Calcium_homeostasis" title="Special:EditPage/Template:Calcium homeostasis"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Calcium_homeostasis_(H05)" style="font-size:114%;margin:0 4em"><a href="/wiki/Calcium" title="Calcium">Calcium</a> <a href="/wiki/Homeostasis" title="Homeostasis">homeostasis</a> (<a href="/wiki/ATC_code_H05" title="ATC code H05">H05</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Parathyroid_hormone" title="Parathyroid hormone">Parathyroid hormone</a> and analogues</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abaloparatide" title="Abaloparatide">Abaloparatide</a></li> <li><a href="/wiki/Palopegteriparatide" title="Palopegteriparatide">Palopegteriparatide</a></li> <li><a href="/w/index.php?title=Parathyroid_gland_extract&action=edit&redlink=1" class="new" title="Parathyroid gland extract (page does not exist)">Parathyroid gland extract</a></li> <li><a href="/wiki/Teriparatide" title="Teriparatide">Teriparatide</a></li> <li><a href="/wiki/Recombinant_human_parathyroid_hormone" title="Recombinant human parathyroid hormone">Recombinant human parathyroid hormone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Anti-parathyroid hormone agents</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Calcitonin derivatives</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcitonin" title="Calcitonin">Calcitonin</a></li> <li><a href="/wiki/Elcatonin" title="Elcatonin">Elcatonin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Calcimimetics</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cinacalcet" title="Cinacalcet">Cinacalcet</a></li> <li><a href="/wiki/Etelcalcetide" title="Etelcalcetide">Etelcalcetide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcifediol" title="Calcifediol">Calcifediol</a></li> <li><a href="/wiki/Calcitriol" title="Calcitriol">Calcitriol</a></li> <li><a href="/wiki/Cholecalciferol" title="Cholecalciferol">Cholecalciferol</a></li> <li><a href="/wiki/Cinacalcet" title="Cinacalcet">Cinacalcet</a></li> <li><a href="/wiki/Doxercalciferol" title="Doxercalciferol">Doxercalciferol</a></li> <li><a href="/wiki/Ergocalciferol" title="Ergocalciferol">Ergocalciferol</a></li> <li><a href="/wiki/Etelcalcetide" title="Etelcalcetide">Etelcalcetide</a></li> <li><a href="/wiki/Evocalcet" title="Evocalcet">Evocalcet</a></li> <li><a class="mw-selflink selflink">Paricalcitol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Vitamin_D_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Vitamin_D_receptor_modulators" title="Template:Vitamin D receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Vitamin_D_receptor_modulators" title="Template talk:Vitamin D receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Vitamin_D_receptor_modulators" title="Special:EditPage/Template:Vitamin D receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Vitamin_D_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Vitamin_D_receptor" title="Vitamin D receptor">Vitamin D receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vitamin_D_receptor" title="Vitamin D receptor"><abbr title="Vitamin D receptor">VDR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Vitamin D receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/7-Dehydrocholesterol" title="7-Dehydrocholesterol">7-Dehydrocholesterol</a></li> <li><a href="/w/index.php?title=25-Hydroxyergocalciferol&action=edit&redlink=1" class="new" title="25-Hydroxyergocalciferol (page does not exist)">25-Hydroxyergocalciferol</a></li> <li><a href="/wiki/Alfacalcidol" title="Alfacalcidol">Alfacalcidol</a></li> <li><a href="/wiki/Calcifediol" title="Calcifediol">Calcifediol</a></li> <li><a href="/wiki/Calciferol" class="mw-redirect" title="Calciferol">Calciferol</a></li> <li><a href="/wiki/Calcipotriol" title="Calcipotriol">Calcipotriol</a></li> <li><a href="/wiki/Calcitriol" title="Calcitriol">Calcitriol</a></li> <li><a href="/wiki/Cholecalciferol" title="Cholecalciferol">Cholecalciferol</a> (<a href="/wiki/Vitamin_D3" class="mw-redirect" title="Vitamin D3">vitamin D<sub>3</sub></a>)</li> <li><a href="/wiki/Dihydrotachysterol" title="Dihydrotachysterol">Dihydrotachysterol</a></li> <li><a href="/wiki/Doxercalciferol" title="Doxercalciferol">Doxercalciferol</a></li> <li><a href="/w/index.php?title=EB-1089&action=edit&redlink=1" class="new" title="EB-1089 (page does not exist)">EB-1089</a></li> <li><a href="/wiki/Eldecalcitol" title="Eldecalcitol">Eldecalcitol</a></li> <li><a href="/w/index.php?title=Ercalcidiol&action=edit&redlink=1" class="new" title="Ercalcidiol (page does not exist)">Ercalcidiol</a></li> <li><a href="/w/index.php?title=Ercalcitriol&action=edit&redlink=1" class="new" title="Ercalcitriol (page does not exist)">Ercalcitriol</a></li> <li><a href="/wiki/Ergocalciferol" title="Ergocalciferol">Ergocalciferol</a> (<a href="/wiki/Vitamin_D2" class="mw-redirect" title="Vitamin D2">vitamin D<sub>2</sub></a>)</li> <li><a href="/wiki/Lithocholic_acid" title="Lithocholic acid">Lithocholic acid</a></li> <li><a href="/wiki/Maxacalcitol" title="Maxacalcitol">Maxacalcitol</a></li> <li><a class="mw-selflink selflink">Paricalcitol</a></li> <li><a href="/wiki/Tacalcitol" title="Tacalcitol">Tacalcitol</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ZK159222&action=edit&redlink=1" class="new" title="ZK159222 (page does not exist)">ZK159222</a></li> <li><a href="/w/index.php?title=TEI-9647&action=edit&redlink=1" class="new" title="TEI-9647 (page does not exist)">TEI-9647</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><i><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></i></dd></dl> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Paricalcitol&oldid=1249985889">https://en.wikipedia.org/w/index.php?title=Paricalcitol&oldid=1249985889</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Secosteroids" title="Category:Secosteroids">Secosteroids</a></li><li><a href="/wiki/Category:Vitamin_D" title="Category:Vitamin D">Vitamin D</a></li><li><a href="/wiki/Category:Drugs_developed_by_AbbVie" title="Category:Drugs developed by AbbVie">Drugs developed by AbbVie</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks 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