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<!DOCTYPE html> <html lang="ko"> <head> <title>OASIS Repository@POSTECHLIBRARY: High-resolution profiling of histone methylations in the human genome</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="Generator" content="DSpace 5.5" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="description" content="Postech OASIS Repository" /> <meta name="keywords" content="오아시스,레포지토리,리포지터리,저장소,포스텍,박태준학술정보관,포항공과대학교,포항공대,POSTECH,Pohang University of Science and Technology,도서관,IR,연구업적,학술실적,연구성과,dspace" /> <link rel="shortcut icon" href="/favicon.ico" type="image/x-icon"/> <link rel="search" type="application/opensearchdescription+xml" href="/open-search/description.xml" title="DSpace" /> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <link rel="schema.OAK" href="http://www.oak.go.kr/terms/" /> <meta name="OAK.author" content="Barski, A" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Cuddapah, S" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Cui, KR" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Roh, TY" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Schones, DE" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Wang, ZB" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Wei, G" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Chepelev, I" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Zhao, KJ" scheme="OAK.AUTHOR" /> <meta name="DCTERMS.dateAccepted" content="2016-04-01T08:52:51Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.available" content="2016-04-01T08:52:51Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.created" content="2009-08-18" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.issued" content="2007-05-18" scheme="DCTERMS.W3CDTF" /> <meta name="OAK.identifier.issn" content="0092-8674" scheme="OAK.ISSN" /> <meta name="DC.identifier" content="2007-OAK-0000016574" /> <meta name="DC.identifier" content="https://oasis.postech.ac.kr/handle/2014.oak/28971" scheme="DCTERMS.URI" /> <meta name="DCTERMS.abstract" content="Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified. The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5 are all linked to gene activation, whereas trimethylations of H3K27, H3K9, and H3K79 are linked to repression. H2A.Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains. Chromosome banding patterns are correlated with unique patterns of histone modifications. Chromosome breakpoints detected in T cell cancers frequently reside in chromatin regions associated with H3K4 methylations. Our data provide new insights into the function of histone methylation and chromatin organization in genome function." /> <meta name="DC.description" content="X" /> <meta name="DC.language" content="English" /> <meta name="DC.publisher" content="CELL PRESS" /> <meta name="DC.relation" content="CELL" /> <meta name="DC.subject" content="EMBRYONIC STEM-CELLS" /> <meta name="DC.subject" content="ACTIVE GENES" /> <meta name="DC.subject" content="T-CELLS" /> <meta name="DC.subject" content="DEVELOPMENTAL REGULATORS" /> <meta name="DC.subject" content="SACCHAROMYCES-CEREVISIAE" /> <meta name="DC.subject" content="MAMMALIAN CHROMATIN" /> <meta name="DC.subject" content="CODING REGIONS" /> <meta name="DC.subject" content="WIDE" /> <meta name="DC.subject" content="H2A.Z" /> <meta name="DC.subject" content="H3" /> <meta name="DC.title" content="High-resolution profiling of histone methylations in the human genome" /> <meta name="DC.type" content="Article" /> <meta name="DC.contributor" content="생명과학과" /> <meta name="DC.identifier" content="10.1016/J.CELL.2007.05.009" /> <meta name="DC.relation" content="129" /> <meta name="DC.relation" content="4" /> <meta name="DC.relation" content="823" /> <meta name="DC.relation" content="837" /> <meta name="DC.contributor" content="10138348" /> <meta name="DC.relation" content="CELL" /> <meta name="DC.relation" content="SCI급, SCOPUS 등재논문" /> <meta name="DC.relation" content="SCI" /> <meta name="DC.identifier" content="7445" /> <meta name="DC.type" content="ART" /> <meta name="DC.identifier" content="CELL, v.129, no.4, pp.823 - 837" /> <meta name="DC.identifier" content="000246788300025" /> <meta name="DC.date" content="2019-02-01" scheme="DCTERMS.W3CDTF" /> <meta name="OAK.relation.page" content="837" scheme="OAK.PAGE" /> <meta name="OAK.relation.issue" content="4" scheme="OAK.ISSUE" /> <meta name="OAK.relation.page" content="823" scheme="OAK.PAGE" /> <meta name="OAK.relation.journal" content="CELL" scheme="OAK.JOURNAL" /> <meta name="OAK.relation.volume" content="129" scheme="OAK.VOLUME" /> <meta name="DC.contributor" content="Roh, TY" /> <meta name="DC.identifier" content="2-s2.0-34249026300" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="3825" /> <meta name="DC.description" content="3792" xml:lang="*" /> <meta name="DC.date" content="2018-05-121" xml:lang="*" scheme="DCTERMS.W3CDTF" /> <meta name="DC.type" content="Article" /> <meta name="DC.subject" content="EMBRYONIC STEM-CELLS" /> <meta name="DC.subject" content="ACTIVE GENES" /> <meta name="DC.subject" content="T-CELLS" /> <meta name="DC.subject" content="DEVELOPMENTAL REGULATORS" /> <meta name="DC.subject" content="SACCHAROMYCES-CEREVISIAE" /> <meta name="DC.subject" content="MAMMALIAN CHROMATIN" /> <meta name="DC.subject" content="CODING REGIONS" /> <meta name="DC.subject" content="WIDE" /> <meta name="DC.subject" content="H2A.Z" /> <meta name="DC.subject" content="H3" /> <meta name="DC.relation" content="Biochemistry & Molecular Biology" /> <meta name="DC.relation" content="Cell Biology" /> <meta name="DC.description" content="scie" /> <meta name="DC.description" content="scopus" /> <meta name="DC.relation" content="Biochemistry & Molecular Biology" /> <meta name="DC.relation" content="Cell Biology" /> <meta name="citation_keywords" content="EMBRYONIC STEM-CELLS; 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We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology. Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified. The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5 are all linked to gene activation, whereas trimethylations of H3K27, H3K9, and H3K79 are linked to repression. H2A.Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains. Chromosome banding patterns are correlated with unique patterns of histone modifications. Chromosome breakpoints detected in T cell cancers frequently reside in chromatin regions associated with H3K4 methylations. Our data provide new insights into the function of histone methylation and chromatin organization in genome function.</dd></dl> <dl><dt>Keywords</dt><dd>EMBRYONIC STEM-CELLS; ACTIVE GENES; T-CELLS; DEVELOPMENTAL REGULATORS; SACCHAROMYCES-CEREVISIAE; MAMMALIAN CHROMATIN; CODING REGIONS; WIDE; H2A.Z; H3</dd></dl> <dl><dt>URI</dt><dd><a href="https://oasis.postech.ac.kr/handle/2014.oak/28971" class="link_type">https://oasis.postech.ac.kr/handle/2014.oak/28971</a></dd></dl> <dl><dt>DOI</dt><dd><a href="http://dx.doi.org/10.1016/J.CELL.2007.05.009">10.1016/J.CELL.2007.05.009</a></dd></dl> <dl><dt>ISSN</dt><dd>0092-8674</dd></dl> <dl><dt>Article Type</dt><dd>Article</dd></dl> <dl><dt>Citation</dt><dd>CELL, vol. 129, no. 4, page. 823 - 837, 2007-05-18</dd></dl> <dl class="file_item_dl"><dt>Files in This Item:</dt> <dd class="file_download">There are no files associated with this item.</dd> </dl> </div> <div class="record_bt_box"> <a href="/handle/2014.oak/28971?mode=full">Show full item record</a> </div> <div class="al_right"> </div> <div class="sns_wrap"> <div class="sns_box"> <p class="qr_box"><img src="https://api.qrserver.com/v1/create-qr-code/?size=66x66&data=https://oasis.postech.ac.kr/handle/2014.oak/28971" alt="qr_code"></p> <div class="sns_inner"> <ul> <li> <p><a href="http://www.mendeley.com/import/?url=https://oasis.postech.ac.kr/handle/2014.oak/28971" target="_blank"><img src="/image/common/mendeley_icon.gif" alt="mendeley" /></a></p> <p class="twitter_box"> <a href="https://twitter.com/share" class="tweet_bt twitter-share-button" data-lang="en" data-size="large" data-dnt="true">트윗하기</a> <script> !function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (!d.getElementById(id)) { js = d.createElement(s); js.id = id; js.src = "//platform.twitter.com/widgets.js"; fjs.parentNode.insertBefore(js, fjs); } }(document, "script", "twitter-wjs"); </script> </p> </li> <li class="facebook_li"> <span id="fb-root"></span> <script> (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/ko_KR/all.js#xfbml=1"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); </script> <span class="fb-like" data-send="true" data-layout="standard" data-width="450" data-show-faces="false" data-font="verdana"></span> </li> </ul> </div> </div> <p class="sns_text"> <span> Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.</span> </p> </div> </div> </div>  <div class="sub_right_box"> <div class="w_cc"> <h4 class="widget_title">Communities & Collection</h4> <ul> <li><a href="/handle/2014.oak/398" class="cc_item">General Graduate School of Life Science (일반대학원 생명과학과)</a> <ul> <li><a href="/handle/2014.oak/399">1. 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