VIB.BE - Spatial Catalyst

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class="page-title visually-hidden">Spatial Catalyst</h1> </div> <div class="small-banner full-width block-header-banner-block text-white no-overlay image-focus--" id="banner-block-fd9"> <div class="text-wrapper"> <div class="header-title"> <h1 class="spoof-h2 field field--name-field-title field--type-string title field__item">Spatial Catalyst</h1> </div> </div> <div class="image-background"> <picture> <source srcset="/sites/vib.sites.vib.be/files/styles/small_header_image/public/2023-09/Spatial-banner-1500x560_0.jpg.webp?itok=w90JR-UF 1x, /sites/vib.sites.vib.be/files/styles/small_header_image_x2/public/2023-09/Spatial-banner-1500x560_0.jpg.webp?itok=gRE6awP1 2x" media="(min-width: 1024px)" type="image/webp" width="1340" height="250"/> <source srcset="/sites/vib.sites.vib.be/files/styles/small_header_image_small/public/2023-09/Spatial-banner-1500x560_0.jpg.webp?itok=w6IcI4Qd 1x, 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id="text-one-col-943"> <h2 class="field field--name-field-title field--type-string title field__item">Your Gateway to Spatial Omics Expertise</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>VIB Spatial Catalyst is set up to advance the application of spatial technologies by bringing together expertise and providing support for spatial omics experiments, data analysis and developing bioinformatics tools. Join us in revolutionizing spatial technology applications!</p></div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-third has-full-width-bg has-text" id="image-with-text-df6"> <div class="layout"> <div class="layout__item layout__item-image aos-init" data-aos=fade-right> <a class="non-crop-lightbox" href="/sites/vib.sites.vib.be/files/styles/max_1200x1400/public/2024-06/MACSima_1.jpg.webp?itok=6jbG0x4Y" data-lightbox="1819"> <div class="primary-bg svg-wrapper"> <svg class="icon icon--search"> <use xlink:href="#icon--search"></use> </svg> </div> <picture> <source srcset="/sites/vib.sites.vib.be/files/styles/max_width_950/public/2024-06/MACSima_1.jpg.webp?itok=JB3v8TLL 1x, /sites/vib.sites.vib.be/files/styles/max_width_950_x2/public/2024-06/MACSima_1.jpg.webp?itok=_zwBcesG 2x" media="(min-width: 768px)" type="image/webp" width="950" height="713"/> <source srcset="/sites/vib.sites.vib.be/files/styles/max_width_700/public/2024-06/MACSima_1.jpg.webp?itok=BLgjNeOR 1x, /sites/vib.sites.vib.be/files/styles/max_width_700_x2/public/2024-06/MACSima_1.jpg.webp?itok=TBHpVCp9 2x" media="(min-width: 0px)" type="image/webp" width="700" height="525"/> <img src="/sites/vib.sites.vib.be/files/styles/max_width_700/public/2024-06/MACSima_1.jpg.webp?itok=BLgjNeOR" alt="" /> </picture> </a> <div class="field field--name-field-footnote field--type-string field--label-hidden note field__items"> <div class="field__item">MACSima™ System, Miltenyi Biotec</div> </div> </div> <div class="layout__item layout__item-text aos-init" > <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><h3 id="vibsspatialtechnologies--2">VIB's Spatial Technologies</h3> <p>VIB hosts several cutting-edge spatial technologies in the fields of <strong>spatial transcriptomics</strong>, <strong>proteomics</strong> and <strong>metabolomics</strong> and we offer guidance in selecting the right experimental approach to address your scientific question. Besides our own VIB researchers, we also offer our expertise and devices to other academic and industrial users. Do not hesitate to contact us using the link on the bottom of this page to discuss your project.</p></div> </div> </div> </div> <div class="block block--layout-builder block--inline-blocksteps" id="steps-20e"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><h3 id="empoweryourspatialexplorationtailoredsupportandguidance"><strong>Empower Your Spatial Exploration: Tailored Support and Guidance</strong></h3></div> <div class="field field--name-field-step field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-041"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2023-09/20230919%20Icons%20Spatial%20Catalyst_Path-orange.png.webp?itok=HeFah8zN" width="240" height="240" alt="Icon Spatial How can we help?" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1973">Consultancy</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>We offer consultancy in the field of spatial technologies and can support you with insights into the latest developments in spatial omics, selecting the right experimental approach for your scientific question, provide input for upcoming grant applications and give advice on anything ranging from small questions to large-scale projects. </p></div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-ee3"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/20230919%20Icons%20Spatial%20Catalyst_Collab-orange.png.webp?itok=B2Rw20Ce" width="240" height="240" alt="Icon_Spatial Catalyst_service" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1974">Services</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>In close collaboration with VIB colleagues in the research centers, expertise units, Tech Watch and the VIB core facilities, we are streamlining the acquisition and analysis of spatial data and are already offering several devices in service.</p></div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-981"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/20230919%20Icons%20Spatial%20Catalyst_Analytics-orange.png.webp?itok=YXVM4tQW" width="240" height="240" alt="Icon_Spatial Catalyst_data" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1975">Data Analysis</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>Our Spatial Catalyst bioinformaticians offer guidance and hands-on assistance to determine the best approach for your spatial data. We advise and train you in the use of established analysis pipelines and tools or guide you towards tailored solutions that fit your research questions.</p></div> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-6f6"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/20230919%20Icons%20Spatial%20Catalyst_Training-orange.png.webp?itok=7R-t8bGu" width="240" height="240" alt="Icon_Spatial Catalyst_training" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1976">Training</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>Our goal is to make the spatial field accessible to everyone and foster a spatial community with a collaborative mindset. To achieve this, we organize a variety of training opportunities ranging from data acquisition to data analysis. </p></div> </div> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockquotes has-image parallax has-full-width-bg bg-primary bg-light-text" id="quotes-758"> <div class="field field--name-field-quote field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--quote paragraph--view-mode--default" id="quote-499"> <div class="field field--name-field-quote field--type-string-long field--label-hidden field__items"> <div class="field__item">Spatial omics helps us to understand intercellular relationships by assessing the spatial organization of cells. Working in spatial omics is very exciting because it provides unparalleled insights into cell-to-cell interactions.</div> </div> <div class="person-wrapper"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-cb7662f1e3e" class="media media--blazy media--bundle--image media--image is-b-loading"><img alt="Evelien Van Hamme" decoding="async" class="media__element b-lazy" loading="lazy" data-src="/sites/vib.sites.vib.be/files/styles/thumbnail_square/public/2023-09/20220427-EvelienVanHamme.jpg.webp?itok=NkLMDCHC" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="100" height="100" /> </div> </div> <div class="credentials"> <div class="field field--name-field-name field--type-string field--label-hidden field__item">Evelien Van Hamme</div> <div class="field field--name-field-function field--type-string field--label-hidden field__item">Team Lead Spatial Catalyst</div> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockquotes has-image parallax has-full-width-bg bg-primary bg-light-text background primary-bg overlay-dark"> <div class="blazy is-b-bg blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div class="media media--blazy b-lazy b-bg media--bundle--image media--image media--responsive is-b-loading" data-src="/sites/vib.sites.vib.be/files/styles/cta_medium/public/2024-06/capture%20MECleuven01.png.webp?itok=Ui_LVJnb" data-b-bg="{"768":{"src":"\/sites\/vib.sites.vib.be\/files\/styles\/cta_medium\/public\/2024-06\/capture%20MECleuven01.png.webp?itok=Ui_LVJnb","ratio":43.88000000000000255795384873636066913604736328125},"1440":{"src":"\/sites\/vib.sites.vib.be\/files\/styles\/cta_large\/public\/2024-06\/capture%20MECleuven01.png.webp?itok=y8rszykg","ratio":34.719999999999998863131622783839702606201171875}}" data-b-token="b-8ec51756df2"> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-columns three-col"data-aos=fade-down id="image-columns-cac"> <div class="field field--name-field-image-column field--type-entity-reference-revisions field--label-hidden layout__items"> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-e31"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-4cb3397e4fb" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2024-06/Visium%20-%20Brain.png.webp?itok=0cW2xFee 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2024-06/Visium%20-%20Brain.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="spatial_transcriptomics" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title bg_dark field__item">Spatial Transcriptomics</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Interested in studying<strong> mRNA</strong> within its<strong> </strong>spatial context? Our expertise extends to both <strong>targeted</strong> ( <strong>Xenium</strong>, <strong>MERSCOPE</strong>, & <strong>RNAscope</strong>) and <strong>untargeted</strong> spatial transcriptomics  (<strong>Visium</strong>, <strong>Visium HD</strong>, <strong>StereoSeq</strong>, & <strong>Curio Seeker</strong>).”</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://connect.vib.be/facilities/spatial-catalyst/devices?category=7880e41c-4204-4b52-b1e6-b559b2c85594" target="_blank"> <span>Discover our Devices</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-6fb"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-4beeaa1f264" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2024-06/cell%20culture.png.webp?itok=6xMSl4GC 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2024-06/cell%20culture.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="spatial_metabolomics" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title bg_dark field__item">Spatial Metabolomics</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Does your research require spatially-resolved<strong> metabolites </strong>or<strong> lipids</strong>? Work with the VIB Spatial Catalyst and Metabolomics Core Leuven to enhance your research with our cutting-edge technologies:<strong> timsTOF fleX MALDI-2</strong>, <strong>DESI-XS MRT</strong> & <strong>Scimax MR-MS</strong>.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://connect.vib.be/facilities/metabolomics-core-leuven/devices?category=ebdddff3-c161-4623-b9f1-6538f6986bea" target="_blank"> <span>Discover our Devices</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-435"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-2f7008c7cf7" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2024-06/MACSima%20-%20Moyamoya.png.webp?itok=0UvNkrBc 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2024-06/MACSima%20-%20Moyamoya.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="Spatial_Proteomics" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title bg_dark field__item">Spatial Proteomics</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Are you fascinated by exploring high-plex<strong> protein </strong>expression and localization? Our expertise extends to state-of-the-art devices such as <strong>MACSima</strong>, <strong>PhenoCycler</strong> <strong>Fusion</strong>, & <strong>Opal, </strong>enabling us to provide comprehensive solutions for your research needs.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://connect.vib.be/facilities/spatial-catalyst/devices?category=7880e41c-4204-4b52-b1e6-b559b2c85594" target="_blank"> <span>Discover our Devices</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockseparator" id="separator-a8b"> <div class="separator"></div> </div> <div class="block block--layout-builder block--inline-blocksteps" id="steps-d55"> <h2 class="field field--name-field-title field--type-string title field__item">Press & Publications</h2> <div class="field field--name-field-step field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-e8e"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/Spatial_catalyst_poster_tumbnail.png.webp?itok=dcq1lkAQ" width="240" height="240" alt="Spatial poster" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1993">Benchmarking targeted spatial transcriptomics technologies (conference poster 14/7/2024)</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>In recent years, targeted spatial transcriptomics technologies have become increasingly accessible with the advent of commercial platforms like Xenium (10X Genomics), MERSCOPE (Vizgen), Molecular Cartography (Resolve Biosciences), and CosMx SMI (NanoString). While these imaging-based platforms offer tantalizing opportunities for researchers by providing the spatial context of an extensive gene expression panel with subcellular resolution, it has long remained unclear how these technologies compare in terms of technical performance and user experience.</p></div> </div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://figshare.com/articles/poster/Benchmarking_targeted_spatial_transcriptomics_technologies_conference_poster_14_7_2024_/26056669" target="_blank"> <span>More information</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-756"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/spatial%20liver%20map.jpg.webp?itok=DRW87eT_" width="240" height="240" alt="Spatial_liver_map" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1981">Spatial Omics: understanding life in 3D</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>Recent advances in the life sciences have given researchers increasingly detailed insights into the molecular mechanisms underlying health and disease. One thing, however, is missing: the spatial dimension. Spatial omics seeks to remedy this and VIB has invested in this suite of technologies since it burst on the scene. But what is spatial omics, and what are the challenges that remain?  </p></div> </div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://blog.vib.be/spatial-omics-understanding-life-in-3d" target="_blank"> <span>VIB Blog</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-34f"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/painting%20ani%20ther%C3%A9.png.webp?itok=UJR3wSUQ" width="240" height="240" alt="painting_ani_theré" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1982">Conversations with experts: the art of Spatial Omics</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>In anticipation of the upcoming Spatial Omics Conference June 2024, we had the pleasure of speaking with two experts and organizing committee members. The first is Johan Swinnen, head of the Laboratory of Lipid Metabolism and Cancer at KU Leuven. The other expert is Evelien Van Hamme, who leads the <strong>VIB</strong> <strong>Spatial Catalyst</strong> at VIB. Each, in their own way, is an expert in spatial omics, a technique that is transforming our understanding of biological tissues.  </p></div> </div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://blog.vib.be/conversations-with-experts-the-art-of-spatial-omics" target="_blank"> <span>VIB Blog</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-057"> <div class="line-wrapper "> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2024-06/spatial%20melanoma.png.webp?itok=ubWawfuO" width="240" height="240" alt="Spatial_melanoma" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1984">A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>Researchers of the VIB Marine lab investigated intrinsic resistance to immune checkpoint blockade (ICB) in melanoma. Using single-cell, spatial multi-omics techniques, they analysed the cellular architecture of treatment-naive melanoma. Melanoma cells with a mesenchymal-like (MES) state, associated with therapy resistance, were enriched in non-responders’ early on-treatment biopsies. The central regulator TCF4 suppresses melanocytic and antigen presentation programs while orchestrating multiple transcriptional processes, contributing to resistance to both targeted therapy and ICB in melanoma.</p></div> </div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://www.cell.com/cell/fulltext/S0092-8674(23)01322-3?_returnURL=https%3A//linkinghub.elsevier.com/retrieve/pii/S0092867423013223%3Fshowall%3Dtrue" target="_blank"> <span>Ponzniak et al, 2024</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--step paragraph--view-mode--default" id="step-14d"> <div class="line-wrapper primary-bg"> <div class="field field--name-field-image field--type-entity-reference field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item"> <img loading="lazy" src="/sites/vib.sites.vib.be/files/styles/thumbnail_square_medium/public/2022-12/capture%20tech%20watch02_0.PNG.webp?itok=-H8egRaL" width="240" height="240" alt="tech watch" class="image-style-thumbnail-square-medium" /> </div> </div> </div> <div class="content-wrapper aos-init" data-aos=fade-left> <h3 class="field field--name-field-title field--type-string title field__item" id="-1983">VIB Spatial Catalyst capitalizes on diverse omics talent to professionalize spatial technology activities</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-visually_hidden"> <div class="field__label visually-hidden">Text</div> <div class="field__item"><p>Spatial omics technologies are an emerging discipline in scientific research that have been steadily gaining importance over the past few years. Building on VIB Technologies’ broad range of technological expertise, VIB is leveraging spatial technologies through its new Spatial Catalyst unit. In doing so, the organization hopes to make spatial technologies more accessible, integrating it in all layers of its research activities.</p></div> </div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://press.vib.be/vib-spatial-catalyst-capitalizes-on-diverse-omics-talent-to-professionalize-spatial-technology-activities"> <span>VIB Press</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--right media-width--one-third has-text" id="image-with-text-af2"> <div class="layout"> <div class="layout__item layout__item-image aos-init" data-aos=fade-left> <picture> <source srcset="/sites/vib.sites.vib.be/files/styles/max_width_950/public/2024-11/spatial_catalyst_group.jpg.webp?itok=6v-p9v_D 1x, /sites/vib.sites.vib.be/files/styles/max_width_950_x2/public/2024-11/spatial_catalyst_group.jpg.webp?itok=gA1tl3Bc 2x" media="(min-width: 768px)" type="image/webp" width="950" height="761"/> <source srcset="/sites/vib.sites.vib.be/files/styles/max_width_700/public/2024-11/spatial_catalyst_group.jpg.webp?itok=lSp_l9za 1x, /sites/vib.sites.vib.be/files/styles/max_width_700_x2/public/2024-11/spatial_catalyst_group.jpg.webp?itok=Q-OKXLXp 2x" media="(min-width: 0px)" type="image/webp" width="700" height="561"/> <img src="/sites/vib.sites.vib.be/files/styles/max_width_700/public/2024-11/spatial_catalyst_group.jpg.webp?itok=lSp_l9za" alt="" /> </picture> </div> <div class="layout__item layout__item-text aos-init" data-aos=fade-right> <h2 class="field field--name-field-title field--type-string title field__item">Our Team</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>"The ambition of the Spatial Catalyst is to make spatial technologies accessible to all our scientists. We want to map out, reinforce and promote the use of our existing infrastructure and expertise in this area to aid scientists in leveraging the technology for their research. We already have some very nice proofpoints of how VIB has leveraged spatial technologies in the past, showing just how well it can contribute to breakthrough science. That’s why this is such an important ambition for us."<br> (Evelien Van Hamme)</p></div> </div> </div> </div> <div class="block block--layout-builder block--inline-blocktext-one-col aos-init" data-aos=fade-down id="text-one-col-caa"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><h3 id="readytoembarkonyourspatialjourneynbsp">Ready to embark on your spatial journey? </h3> <p>Get in touch with us to discover how VIB Spatial Catalyst can elevate your research to new heights. 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= elem.className + ' _has_error'; no_error = false; tooltip = create_tooltip(elem, "This field is required."); } } if (no_error && (elem.id == 'field[]' || elem.id == 'ca[11][v]')) { if (elem.className.includes('phone-input-error')) { elem.className = elem.className + ' _has_error'; no_error = false; } } if (no_error && elem.name == 'email') { if (!value.match(/^[\+_a-z0-9-'&=]+(\.[\+_a-z0-9-']+)*@[a-z0-9-]+(\.[a-z0-9-]+)*(\.[a-z]{2,})$/i)) { elem.className = elem.className + ' _has_error'; no_error = false; tooltip = create_tooltip(elem, "Enter a valid email address."); } } if (no_error && /date_field/.test(elem.className)) { if (!value.match(/^\d\d\d\d-\d\d-\d\d$/)) { elem.className = elem.className + ' _has_error'; no_error = false; tooltip = create_tooltip(elem, "Enter a valid date."); } } tooltip ? resize_tooltip(tooltip) : false; return no_error; }; var needs_validate = function(el) { if(el.getAttribute('required') !== null){ return true } if(el.name === 'email' && el.value !== ""){ return true } if((el.id == 'field[]' || el.id == 'ca[11][v]') && el.className.includes('phone-input-error')){ return true } return false }; var validate_form = function(e) { var err = form_to_submit.querySelector('._form_error'), no_error = true; if (!submitted) { submitted = true; for (var i = 0, len = allInputs.length; i < len; i++) { var input = allInputs[i]; if (needs_validate(input)) { if (input.type == 'tel') { addEvent(input, 'blur', function() { this.value = this.value.trim(); validate_field(this, true); }); } if (input.type == 'text' || input.type == 'number' || input.type == 'time') { addEvent(input, 'blur', function() { this.value = this.value.trim(); validate_field(this, true); }); addEvent(input, 'input', function() { validate_field(this, true); }); } else if (input.type == 'radio' || input.type == 'checkbox') { (function(el) { var radios = form_to_submit.elements[el.name]; for (var i = 0; i < radios.length; i++) { addEvent(radios[i], 'click', function() { validate_field(el, true); }); } })(input); } else if (input.tagName == 'SELECT') { addEvent(input, 'change', function() { validate_field(this, true); }); } else if (input.type == 'textarea'){ addEvent(input, 'input', function() { validate_field(this, true); }); } } } } remove_tooltips(); for (var i = 0, len = allInputs.length; i < len; i++) { var elem = allInputs[i]; if (needs_validate(elem)) { if (elem.tagName.toLowerCase() !== "select") { elem.value = elem.value.trim(); } validate_field(elem) ? true : no_error = false; } } if (!no_error && e) { e.preventDefault(); } resize_tooltips(); return no_error; }; addEvent(window, 'resize', resize_tooltips); addEvent(window, 'scroll', resize_tooltips); var hidePhoneInputError = function(inputId) { var errorMessage = document.getElementById("error-msg-" + inputId); var input = document.getElementById(inputId); errorMessage.classList.remove("phone-error"); errorMessage.classList.add("phone-error-hidden"); input.classList.remove("phone-input-error"); }; var initializePhoneInput = function(input, defaultCountry) { return window.intlTelInput(input, { utilsScript: "https://unpkg.com/intl-tel-input@17.0.18/build/js/utils.js", autoHideDialCode: false, separateDialCode: true, initialCountry: defaultCountry, preferredCountries: [] }); } var setPhoneInputEventListeners = function(inputId, input, iti) { input.addEventListener('blur', function() { var errorMessage = document.getElementById("error-msg-" + inputId); if (input.value.trim()) { if (iti.isValidNumber()) { iti.setNumber(iti.getNumber()); if (errorMessage.classList.contains("phone-error")){ hidePhoneInputError(inputId); } } else { showPhoneInputError(inputId) } } else { if (errorMessage.classList.contains("phone-error")){ hidePhoneInputError(inputId); } } }); input.addEventListener("countrychange", function() { iti.setNumber(''); }); input.addEventListener("keydown", function(e) { var charCode = (e.which) ? e.which : e.keyCode; if (charCode > 31 && (charCode < 48 || charCode > 57) && charCode !== 8) { e.preventDefault(); } }); }; var showPhoneInputError = function(inputId) { var errorMessage = document.getElementById("error-msg-" + inputId); var input = document.getElementById(inputId); errorMessage.classList.add("phone-error"); errorMessage.classList.remove("phone-error-hidden"); input.classList.add("phone-input-error"); }; window['recaptcha_callback'] = function() { // Get all recaptchas in the DOM (there may be more than one form on the page). var recaptchas = document.getElementsByClassName("g-recaptcha"); for (var i in recaptchas) { // Set the recaptcha element ID, so the recaptcha can be applied to each element. var recaptcha_id = "recaptcha_" + i; recaptchas[i].id = recaptcha_id; var el = document.getElementById(recaptcha_id); if (el != null) { var sitekey = el.getAttribute("data-sitekey"); var stoken = el.getAttribute("data-stoken"); grecaptcha.render(recaptcha_id, {"sitekey":sitekey,"stoken":stoken}); } } }; _load_script("https://www.google.com/recaptcha/api.js?onload=recaptcha_callback&render=explicit"); var _form_serialize = function(form){if(!form||form.nodeName!=="FORM"){return }var i,j,q=[];for(i=0;i<form.elements.length;i++){if(form.elements[i].name===""){continue}switch(form.elements[i].nodeName){case"INPUT":switch(form.elements[i].type){case"tel":q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].previousSibling.querySelector('div.iti__selected-dial-code').innerText)+encodeURIComponent(" ")+encodeURIComponent(form.elements[i].value));break;case"text":case"number":case"date":case"time":case"hidden":case"password":case"button":case"reset":case"submit":q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].value));break;case"checkbox":case"radio":if(form.elements[i].checked){q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].value))}break;case"file":break}break;case"TEXTAREA":q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].value));break;case"SELECT":switch(form.elements[i].type){case"select-one":q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].value));break;case"select-multiple":for(j=0;j<form.elements[i].options.length;j++){if(form.elements[i].options[j].selected){q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].options[j].value))}}break}break;case"BUTTON":switch(form.elements[i].type){case"reset":case"submit":case"button":q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].value));break}break}}return q.join("&")}; var form_submit = function(e) { e.preventDefault(); if (validate_form()) { // use this trick to get the submit button & disable it using plain javascript document.querySelector('#_form_6_submit').disabled = true; var serialized = _form_serialize(document.getElementById('_form_6_')).replace(/%0A/g, '\\n'); var err = form_to_submit.querySelector('._form_error'); err ? err.parentNode.removeChild(err) : false; _load_script('https://vib.activehosted.com/proc.php?' + serialized + '&jsonp=true'); } return false; }; addEvent(form_to_submit, 'submit', form_submit); })(); </script> </div> </div> </div> </div> </div> </div> </section> <section class="footer"> <div class="region__inner"> <div class="footer__content"> <div class="region region--footer-top"> <div class="region__inner"> <div class="block block--system block--system-breadcrumb-block" id="block-system-breadcrumb-block" id=""> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"><h2 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