Conventional Formulation Technology Pharmaceutical CDMO & CRO Services

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class="sep_container m_width"> <div class="div_boxs flex"> <i class="fa fa-map-marker"></i> <ul class="breadcrumb"><li><a href="/">Home</a></li><li><a href="/platforms/" title="Technology">Technology</a></li><li><a href="/conventional-formulation.html" title="Conventional Oral Solid Dosage Forms">Conventional Oral Solid Dosage Forms</a></li></ul><script type="application/ld+json">{"@context":"http:\/\/schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/www.crystalpharmatech.com\/","name":"Home"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/www.crystalpharmatech.com\/platforms\/","name":"Technology"}}]}</script> </div> </div> </div> <div class="inner_box single"> <div class="inner_title m_width active"> <h1 class="title second_font">Conventional Oral Solid Dosage Forms</h1> </div> <div class="inner_content m_width fadeInUp wow"> <h2>Challenges of Oral Solid Formulations<br/></h2><p>Most small molecule drugs are formulated as oral solid dosage (OSD) forms, such as tablets or capsules. OSD has been an important part of the global pharmaceutical market. With the recent booming of Biotech and new chemical entities (NCE), the demand for CDMO has increased dramatically. More and more pharma companies focus their resource on discovery and outsource their non-core business, including formulation development and manufacturing to support clinical trials or commercial products. However, often times it is not easy to find a trusted CDMO partner due to the limitation of its technical expertise and service quality. At the same time, there are many challenges across all the formulation development stages for NCEs, for example, limited API supply, tight timeline at early stage development and large API requirement for late stage scale up.<br/></p><p><br/></p><h2>Crystal Pharmatech's Approach<br/></h2><p>To meet the current marketing demand and challenges, Crystal Pharmtech has built state-of-art formulation pilot plant and labs, which are equipped with world-class manufacturing equipment and R&D instruments. Our facility provides holistic formulation development capability for different dosage forms. We are striving to provide the best formulation development approach to our clients and become their trusted internal partner.</p><p><br/></p><p>Compaction simulation is one of the core technologies at Crystal Pharmtech. It can be used to characterize compaction properties of neat API, excipient, and blends, which will guide formulation development strategy. Specifically, it can simulate the compression process parameters, such as main compression force, precompression force, dwell time, etc., from lab, pilot to commercial scale tableting machines. In addition, it can simulate the roller compaction process, e.g. predict the roll pressure for all kinds of dry granulators. With only a few grams of material, the compaction simulator can predict compression parameters for commercial machines with hundreds of kgs scale. It becomes one of the most efficient and reliable tool for the design and scale up of the dry granulation and tableting process.</p><p><br/></p><p>Dosage Forms:</p><p>■ Tablet: Immediate Release (IR), Controlled Release (CR), Bilayer, Mini-tablet</p><p>■ Capsule: Powder, Granules, Multi-particulates, Mini-tab in capsule</p><p>■ Multi-particulates</p><p><br/></p><p>Formulation Process:</p><p>■ Wet Granulation, Dry Granulation, Blending, Milling</p><p>■ Compression, Encapsulation, Pan Coating, Fluid Bed Coating</p> </div> <h2 class="img_show_title m_width fadeInUp wow"> Related Platforms of Crystal Pharmatech </h2> <div class="video_group flex m_width"> <div class="video_item"> <a class="img" href="/enabling-formulation-technology-for-insoluble-compounds.html"> <img src="/uploads/image/20221110/10/formulation-development-for-poorly-water-soluble-drugs_1668047852.jpg" alt="Bioavailability Enhancement for Insoluble Compounds & PROTAC & Oral Peptides" title="Bioavailability Enhancement for 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