Estudios de toxicología y bioinformática

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} .innolab .content-single-service .grid-com__col--content #field_3_6 { display: none; } .innolab .tem-team-row .br-line { display: none; } /*ENSAYOS SINGLE*/ .page-ensayos-data .main-content .grid-com__col--content.br-line{ border-top: none !important; padding-top: 0 !important } .card-link-row { border-bottom: none !important; } @media screen and (max-width: 767.98px) { .page-ensayos-data .grid-com__col { padding-top: 0 !important; } } .tipo-ensayo { display: block; background-size: cover; background-position: center; background-repeat: no-repeat; text-transform: uppercase; text-decoration: none !important; font-size: 24px; color: white !important; aspect-ratio: 1 / 1; width: 100%; height: 100%; padding: 50% 15px 15px 15px; } .tipo-ensayo-link { display: block; background-size: cover; background-position: center; background-repeat: no-repeat; aspect-ratio: 1 / 1; width: 100%; height: 100%; overflow: hidden; } .tipo-ensayo-link img { width: 100% !important; height: 100% !important; object-fit: cover; transition: all 0.3s ease-in-out; } .tipo-ensayo-link-bottom { text-transform: uppercase; text-decoration: none !important; font-size: 24px; padding: 15px; position: absolute; width: 100%; top: 48%; pointer-events: none; } .tipo-ensayo-link-bottom a { display: block; border-top: 2px solid #ffffff !important; color: white !important; background-color: transparent !important; padding-left: 0; padding-right: 0; padding-top: 10px; padding-bottom: 0; } .tipo-ensayo-link-bottom a span { font-size: 24px !important; } .postid-14670 .text-double-row__container .wysiwyg-block { position: relative; } .page-ensayos-data .text-double-row__container .wysiwyg-block { position: relative; } .card-link-row__grid { display: flex; justify-content: center; flex-wrap: wrap; gap: 1.5rem; } .card-link-row__grid li { width: calc(24.33% - 0.75rem); position: relative; } .card-link-row__grid li a::before { display: none; } .card-link-row__grid li > a, .card-link-row__grid li> a img{ position: relative; } .tipo-ensayo-background { height: 100%; width: 100%; display: block; position: absolute; top: 0; left: 0; background: radial-gradient(circle, rgba(38, 105, 110, 0) 25%, rgba(38, 105, 110, 1) 100%); z-index: 3; opacity: 0; transition: all 0.3s ease-in-out; } .tipo-ensayo-link-bottom { padding: 15px; position: absolute; width: 100%; top: 48%; pointer-events: none; } .card-link-row__grid li .button__text{ display: block; padding-top: 5px; font-size: 20px !important; color: #ffffff; text-transform: uppercase; border-top: 2px solid #ffffff !important; } @media (max-width: 992px) { .card-link-row__grid li { width: calc(50% - 0.75rem); } } @media (max-width: 650px) { .card-link-row__grid li { width: calc(100% - 0.75rem); } .tipo-ensayo-link-bottom { bottom: 0; top: unset; } } @media (max-width: 1200px) { .card-link-row__grid li .button__text{ font-size: 18px !important; } } @media (min-width: 768px) { .tipo-ensayo-link:hover img { transform: scale(1.1); } .tipo-ensayo-link:hover .tipo-ensayo-background { opacity: 1; } .card-link-row__grid li > a::after { content: ''; display: block; position: absolute; width: 33%; height: 300px; background-color: #FFFFFF; transform: rotate(45deg); top: -75%; left: 0; top: -34%; left: -10%; z-index: 3; } } @media (min-width: 992px) { .tipo-ensayo-link-bottom { top: 28%; } .card-link-row__grid li > a::after { top: -72%; left: 0; } } @media (min-width: 1200px) { .card-link-row__grid li > a::after { top: -64%; left: 0; } .page-ensayos-data .item-team-row__col.item-team-row__image { padding-right: 15%; } } @media (min-width: 1440px) { .tipo-ensayo-link-bottom { top: 50%; } .card-link-row__grid li > a::after { top: -56%; } } @media (min-width: 1600px) { .card-link-row__grid li > a::after { top: -52%; } } .page-ensayos-data .text-double-row__col .wysiwyg-block { font-weight: 500; display: flex; flex-direction: column; justify-content: space-between; height: 100%; } .page-ensayos-data .text-double-row__col .wysiwyg-block img { margin-bottom: 0 !important; } .page-ensayos-data .text-double-row__col .wysiwyg-block p { margin-bottom: 24px !important; } /*SOLUCIONES SEGURIDAD ALIMENTARIA */ .single-soluciones.postid-14837 .header-page, .single-soluciones.postid-14837 .grid-com__col--sidebar { display: none; } .single-soluciones.postid-14837 .content-single-service__container.size-full { width: 100% !important; max-width: 100% !important; } .single-soluciones.postid-14837 .grid-com__col--content { grid-column: span 12 !important; } .single-soluciones.postid-14837 .grid-com__col--content > section, .single-soluciones.postid-14837 .grid-com__col--content > div, .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row .swiper-normal-pagination { width: var(--size-full) !important; max-width: var(--size-full) !important; margin: auto; } .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row { width: 100% !important; max-width: 100% !important; position: relative; } .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row .swiper-normal-pagination { position: absolute; transform: translateX(-50%); left: 50%; bottom: 50px; z-index: 1; } .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row .swiper-pagination.swiper-pagination-fraction, .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row .swiper-pagination.swiper-pagination-fraction .swiper-pagination-current, .single-soluciones.postid-14837, .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row .button__icon i{ color: #ffffff !important; } .grid-com__col--content > section.slider-row .slider-progress__bar { background: #ffffff !important; } .single-soluciones.postid-14837 .grid-com__col--content > section.slider-row .swiper-button { border: 1px solid #ffffff !important; } @media (min-width: 992px) { .single-soluciones.postid-14837 .grid-com__col--content > div:first-of-type > ul { display: flex !important; flex-wrap: wrap; gap: 20px; } .single-soluciones.postid-14837 .grid-com__col--content > .accordion-row ul li{ width: calc(50% - 10px) !important; } .single-soluciones.postid-14837 .grid-com__col--content > div:last-of-type > ul { display: flex !important; flex-direction: column; flex-wrap: wrap; align-items: center; } } /*ENSAYOS*/ .page-ensayos-data .grid-com__col--sidebar { display: none; } .page-ensayos-data .main-content { padding-top: 25px !important; } .page-ensayos-data .legal-content.size-full { width: 100% !important; max-width: 100% !important; } .page-ensayos-data .grid-com__col--content { grid-column: span 12 !important; } .page-ensayos-data .grid-com__col--content > section, .page-ensayos-data .grid-com__col--content > div, .page-ensayos-data .grid-com__col--content > section.slider-row .swiper-normal-pagination { width: var(--size-full) !important; max-width: var(--size-full) !important; margin: auto; } .page-ensayos-data .grid-com__col--content > section{ border-bottom: 1px solid #26696E; margin-bottom: 2.5rem; } .page-ensayos-data .grid-com__col--content > section.text-row, .page-ensayos-data .grid-com__col--content > section.slider-row, .page-ensayos-data .grid-com__col--content > section.text-double-row, .page-ensayos-data .grid-com__col--content > section.team-row { border-bottom:none; margin-bottom: 0; } .page-ensayos-data .grid-com__col--content > section.image-text-row { border-top: 1px solid #26696E; padding-top: 2.5rem; } .page-ensayos-data .grid-com__col--content > section.slider-row { width: 100% !important; max-width: 100% !important; } .page-ensayos-data .item-team-row__col.br-line { display: none; } .page-ensayos-data .grid-com__col--content > section.slider-row .swiper-normal-pagination { position: absolute; transform: translateX(-50%); left: 50%; bottom: 50px; z-index: 1; } .page-ensayos-data .grid-com__col--content > section.slider-row .swiper-pagination.swiper-pagination-fraction, .page-ensayos-data .grid-com__col--content > section.slider-row .swiper-pagination.swiper-pagination-fraction .swiper-pagination-current, .page-ensayos-data .grid-com__col--content > section.slider-row .button__icon i{ color: #ffffff !important; } .page-ensayos-data .swiper-row .slide__image { position: relative; } .page-ensayos-data .swiper-row .slide__image::after { content: ''; height: 100%; width: 100%; background: linear-gradient(90deg, rgba(0,0,0,1) 0%, rgba(0,0,0,0.03125) 73%); background-size: cover; position: absolute; top: 0; left: 0; } .page-ensayos-data .grid-com__col--content > section.slider-row .slider-progress__bar { background: #ffffff !important; } .page-ensayos-data .grid-com__col--content > section.slider-row .swiper-button { border: 1px solid #ffffff !important; } .page-ensayos-data .accordion-wrapper { display: flex; } .page-ensayos-data .accordion-wrapper { display: flex; } @media (min-width: 768px) { .page-ensayos-data .accordion-item { border-top: 1px solid var(--color-light-green) !important; } } @media (min-width: 992px) { .page-ensayos-data .grid-com__col--content .accordion-row > .accordion-wrapper { display: flex !important; flex-wrap: wrap; gap: 20px; } .page-ensayos-data .accordion-item { width: calc(50% - 10px) !important; flex-grow: 1; border-top: 1px solid var(--color-light-green) !important; } .accordion-flex { display: flex; 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<p>El desarrollo y uso de aditivos tecnológicos requiere una correcta evaluación de su potencial efecto tóxico sobre la salud humana y el medio ambiente. En el caso de los nanomateriales, <strong>microplásticos (MP) o nanoplásticos (NP), </strong>es necesario aplicar metodologías adecuadas a las características de estos productos, incluyendo la selección de método in vitro y bioensayos adecuados y representativos de las vías de exposición.</p> <p>En ITENE analizamos la <strong>toxicidad de nanomateriales y micro y nanoplásticos</strong>, así como de aditivos e ingredientes de uso en áreas relevantes como las de envase y embalaje, cosmética e higiene, biocidas o productos fitosanitarios. Este análisis se puede realizar con métodos computacionales (in silico) o bien de forma experimental, mediante ensayos <em>in </em>vitro, que realizamos siguiendo los protocolos establecidos por la OCDE, y empleando las guías y recomendaciones disponibles aplicables a nanomateriales y microplásticos.</p> </div> </div> </div> </section> <section class="slider-row row-block"> <div class="swiper-row swiper"> <div class="swiper-wrapper"> <div class="swiper-slide swiper-no-swiping"> <div class="slide__container"> <div class="slide__container__text"> </div> <div class="slide__image"> <img width="1600" height="900" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201600%20900'%3E%3C/svg%3E" alt="pruebas toxicología" data-swiper-parallax="250" data-lazy-src="https://www.itene.com/wp-content/uploads/2022/03/TOXICOLOGIA-2.jpg"><noscript><img width="1600" height="900" src="https://www.itene.com/wp-content/uploads/2022/03/TOXICOLOGIA-2.jpg" alt="pruebas toxicología" data-swiper-parallax="250"></noscript> </div> </div> </div> <div class="swiper-slide swiper-no-swiping"> <div class="slide__container"> <div class="slide__container__text"> </div> <div class="slide__image"> <img width="1600" height="900" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201600%20900'%3E%3C/svg%3E" alt="Productos químicos" data-swiper-parallax="250" data-lazy-src="https://www.itene.com/wp-content/uploads/2022/03/GENERICAS-Productos-quimicos-1-1.jpg"><noscript><img width="1600" height="900" src="https://www.itene.com/wp-content/uploads/2022/03/GENERICAS-Productos-quimicos-1-1.jpg" alt="Productos químicos" data-swiper-parallax="250"></noscript> </div> </div> </div> <div class="swiper-slide swiper-no-swiping"> <div class="slide__container"> <div class="slide__container__text"> </div> <div class="slide__image"> <img width="1600" height="900" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201600%20900'%3E%3C/svg%3E" alt="Envases para productos químicos" data-swiper-parallax="250" data-lazy-src="https://www.itene.com/wp-content/uploads/2022/03/GENERICAS-Productos-quimicos-2-1.jpg"><noscript><img width="1600" height="900" src="https://www.itene.com/wp-content/uploads/2022/03/GENERICAS-Productos-quimicos-2-1.jpg" alt="Envases para productos químicos" data-swiper-parallax="250"></noscript> </div> </div> </div> </div> <div class="swiper-normal-pagination flex-row items-center justify-center"> <div class="swiper-pagination"></div> <div class="slider-progress"> <div class="slider-progress__bar"></div> </div> <div class="swiper-normal-pagination__buttons swiper-buttons"> <div class="swiper-buttons-container"> <div class="swiper-button slider-button-prev"> <div class="button__icon"> <i class="icon icon-arrow_back"></i> </div> </div> <div class="swiper-button slider-button-next"> <div class="button__icon"> <i class="icon icon-arrow_forward"></i> </div> </div> </div> </div> </div> </div> </section> <section class="text-row row-block"> <div class="text-row__container"> <div class="text-row__content"> <div class="wysiwyg-block"> <h2><strong>¿Qué tipo de estudios toxicológicos realizamos?</strong></h2> <p>En el caso de los <strong>riesgos asociados con la salud humana</strong>, trabajamos con diferentes cultivos celulares de procedencia humana que nos permiten estudiar los efectos asociados, según la vía de entrada al organismo, que se pueden producir sobre la función celular o el material genético, u otros efectos relacionados con problemas de irritación o inflamación.</p> <p>En el caso de los <strong>riesgos asociados al medio ambiente</strong>, estudiamos los efectos tóxicos que estos materiales pueden producir en diferentes matrices ambientales mediante bioensayos, basados en protocolos recomendados por la OCDE y la EPA. Para ello, utilizamos organismos menores (microinvertebrados, algas o protozoos) o plantas, considerados bioindicadores de diferentes matrices con el fin de valorar qué efectos pueden tener sobre el crecimiento, la movilidad o la reproducción en estos organismos.</p> </div> </div> </div> </section> <section class="text-row row-block"> <div class="text-row__container"> <div class="text-row__content"> <div class="wysiwyg-block"> <h2><strong><span class="TextRun SCXW166048827 BCX0" lang="ES-ES" xml:lang="ES-ES" data-contrast="auto"><span class="NormalTextRun SCXW166048827 BCX0">Evaluaciones y modelos predictivos a medida</span></span></strong></h2> <p>En ITENE, desarrollamos estrategias inteligentes de ensayo y métodos de screening (eco)toxicológico para la evaluación de los riesgos que puede suponer la <strong>exposición a agentes químicos, los nanomateriales y nanoproductos</strong> en la industria, así como los efectos de los<strong> micro y nanoplásticos en el medio ambiente</strong>. Para ello, elaboramos informes y planes de bioseguridad, identificamos compuestos activos, realizamos estudios de toxicidad y perfiles toxicológicos y apoyamos la evaluación de riesgos.</p> <p><strong><span class="TextRun SCXW107832677 BCX0" lang="ES-ES" xml:lang="ES-ES" data-contrast="auto"><span class="NormalTextRun SCXW107832677 BCX0">Nuestros servicios se centran en las siguientes áreas:</span></span><span class="EOP SCXW107832677 BCX0" data-ccp-props="{"201341983":0,"335551550":6,"335551620":6,"335559738":90,"335559740":288}"> </span></strong></p> </div> </div> </div> </section> <div class="accordion-row accordion-block row-block"> <ul class="accordion-wrapper"> <li class="accordion-item"> <button class="accordion-button button is--simple click-trigger" data-action="showAccordionItem"> <span class="button__text"> Ensayos de evaluación toxicológica y ecotoxicológica </span> <span class="button__icon"> <i class="icon-keyboard_arrow_down is-close"></i> <i class="icon-keyboard_arrow_up is-open"></i> </span> </button> <div class="accordion-inner"> <div class="wysiwyg-block"> <p>Analizamos la toxicidad de nanomateriales, micro y nanoplásticos, aditivos químicos, y mezclas. Efectuamos estudios de toxicidad y ecotoxicidad, entre los que destacan:</p> <ul> <li>Evaluación de la citotoxicidad y genotoxicidad según la ruta de exposición (inhalación, oral, o dérmica).</li> <li>Evaluación de la sensibilización o irritación dérmica y ocular.</li> <li>Análisis de biomarcadores: generación de especies reactivas (ROS) y factores de inflamación.</li> <li>Ensayos de toxicidad aguda sobre algas y micro-invertebrados a través de bioensayos.</li> </ul> </div> </div> </li> <li class="accordion-item"> <button class="accordion-button button is--simple click-trigger" data-action="showAccordionItem"> <span class="button__text"> Toxicología computacional y bioinformática </span> <span class="button__icon"> <i class="icon-keyboard_arrow_down is-close"></i> <i class="icon-keyboard_arrow_up is-open"></i> </span> </button> <div class="accordion-inner"> <div class="wysiwyg-block"> <p>Aplicamos, desarrollamos y validamos métodos quimio-informáticos como read-across y modelos matemáticos de relación cuantitativa entre estructura y actividad (QSAR) aplicables a la predicción de propiedades fisicoquímicas, biológicas y ambientales de agentes químicos y nanomateriales. Contamos con nuevas herramientas de software para la preparación de fichas de datos de seguridad y la implementación del <strong>Reglamento REACH</strong>. <a href="https://www.itene.com/soluciones/seguridad-gestion-productos-quimicos/" target="_blank" rel="noopener">Conoce qué otros servicios prestamos para apoyar el cumplimiento del Reglamento REACH</a>.</p> </div> </div> </li> <li class="accordion-item"> <button class="accordion-button button is--simple click-trigger" data-action="showAccordionItem"> <span class="button__text"> Uso seguro de nanomateriales </span> <span class="button__icon"> <i class="icon-keyboard_arrow_down is-close"></i> <i class="icon-keyboard_arrow_up is-open"></i> </span> </button> <div class="accordion-inner"> <div class="wysiwyg-block"> <p>Contamos con servicios de consultoría sobre el <strong>Reglamento REACH</strong> para nanomateriales, cuya complejidad conlleva que no existan procedimientos normalizados para evaluar sus riesgos.</p> </div> </div> </li> </ul> </div> <section class="text-row row-block"> <div class="text-row__container"> <div class="text-row__content"> <div class="wysiwyg-block"> <h3><strong><span class="TextRun SCXW212264542 BCX0" lang="ES-ES" xml:lang="ES-ES" data-contrast="none"><span class="NormalTextRun SCXW212264542 BCX0">Beneficios de los estudios toxicológicos y la utilización de modelos predictivos en la empresa</span></span></strong></h3> </div> </div> </div> </section> <section class="image-text-row row-block"> <div class="image-text-row__container"> <div class="image-text-row__grid"> <div class="image-text-row__col"> <div class="wysiwyg-block"> <p>La combinación de los resultados procedentes de estudios toxicológicos y de la aplicación de modelos predictivos es clave para reforzar la seguridad en el uso de nanomateriales y nuevos agentes químicos, y conocer los riesgos que comportan en fases iniciales de desarrollo de producto. Disponer de información (eco)toxicológica en etapas tempranas del desarrollo de nuevos productos, favorece la toma de decisiones, y permite evitar en soluciones que puedan suponer un riesgo para la salud de las personas y el medio ambiente. Entre otros beneficios, destacamos:</p> <ul> <li>Prevención y control de riesgos para la salud humana.</li> <li>Análisis de posibles efectos tóxicos ante la falta de protocolos de ensayo y medios tecnológicos existentes.</li> </ul> </div> </div> <div class="image-text-row__col image-wrapper"> <img width="800" height="450" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20800%20450'%3E%3C/svg%3E" alt="Vista microscopio" class="item-image" data-lazy-src="https://www.itene.com/wp-content/uploads/2022/03/QUIMiOTEC-Fotos-1-1.jpg"><noscript><img width="800" height="450" src="https://www.itene.com/wp-content/uploads/2022/03/QUIMiOTEC-Fotos-1-1.jpg" alt="Vista microscopio" class="item-image"></noscript> </div> </div> </div> </section> <section class="downloads-row row-block"> <div class="downnloads-row__content"> <div class="downloads-row__top br-line"> <h3 class="h5 is--medium downloads-row__title">Descarga nuestro folleto</h3> </div> <ul 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