X-Ray Crystallography Facility | The Huck Institutes (en-US)

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https://www.huck.psu.edu/assets/uploads/background-images/_1920x736_crop_center-center_80_none/xray-site-hero-image.jpg 1920w" sizes="(max-width: 1800px) 100vw, 1920px" src="https://www.huck.psu.edu/assets/uploads/background-images/_1800x690_crop_center-center_80_none/xray-site-hero-image.jpg" class="w-100" alt="X-ray crystallography hero image"> <div class="opacity-dimmer"></div> <div class="container position-absolute jumbotron-copy-position"> <div class="row"> <div class="col-9 pr-0"> <h1>X-Ray Crystallography Facility</h1> <p class="lead d-none d-md-block"> Visualizing and characterize biological macromolecules </p> </div> </div> </div> </div> </div> <div class="container"> <div class="row"> <article class="col-md-9 order-2 py-4"> <p>The X-Ray Crystallography Facility provides the necessary infrastructure and support for individual investigators to undertake single crystal X-ray structural studies. Specifically, we provide instrumentation, training, and collaboration for:<br></p> <ul> <li>Protein characterization, including dynamic light scattering, differential scanning calorimetry, SEC-MALS, multi-wavelength AUC, single-molecule biophysics, and circular dichroism</li> <li>Binding studies using isothermal titration calorimetry</li> <li>Robotic crystallization, incubators, UV, and digital microscopes </li> <li>Robotic imaging</li> <li>Diffraction data collection and processing</li> <li>Structure determination and analysis</li> <li>Molecular modeling</li> <li>Small angle X-ray scattering</li> </ul> <p>Our experienced staff is available to train researchers to use equipment and to assist with project development and research.<br></p> <div class="mb-2 mx-auto"> <div class="embed-responsive embed-responsive-16by9"> <iframe src="https://player.vimeo.com/video/561340075?title=0&byline=0&portrait=0" width="100%" height="100%" frameborder="0" webkitallowfullscreen mozallowfullscreen 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href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility" class="nav-link"> X-Ray Crystallography Facility </a> <ul class="flex-column pl-0 nav"> <li class="nav-item " data-slug="get-started"> <button class="nav-link nav-link-no-link collapsed" href="#16365" data-toggle="collapse" data-target="#16365">Get Started</button> <button class="nav-link collapsed" href="#16365" data-toggle="collapse" data-target="#16365"><i class="fas fa-angle-down fa-lg"></i><i class="fas fa-angle-up fa-lg"></i></button> <div class="collapse second-page " id="16365" aria-expanded="false"> <ul class="flex-column pl-0 nav"> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/get-started/request-form" class="nav-link">Request Form</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/get-started/ilab" class="nav-link">iLab</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/get-started/acknowledgment-and-co-authorship" class="nav-link">Acknowledgment & Co-authorship</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/get-started/for-industry-partners" class="nav-link">For Industry Partners</a> </li> </ul> </div> </li> <li class="nav-item " data-slug="gallery"> <a class="nav-link" href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/gallery">Gallery</a> </li> <li class="nav-item " data-slug="research"> <a class="nav-link" href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/research">Research</a> </li> <li class="nav-item " data-slug="instrumentation"> <button class="nav-link nav-link-no-link collapsed" href="#16389" data-toggle="collapse" data-target="#16389">Instrumentation</button> <button class="nav-link collapsed" href="#16389" data-toggle="collapse" data-target="#16389"><i class="fas fa-angle-down fa-lg"></i><i class="fas fa-angle-up fa-lg"></i></button> <div class="collapse second-page " id="16389" aria-expanded="false"> <ul class="flex-column pl-0 nav"> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/art-robbins-instruments-phoenix-protein-crystallization-robot" class="nav-link">Art Robbins Instruments Phoenix Protein Crystallization Robot</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/beckman-optima-multiwavelength-analytical-ultracentrifuge" class="nav-link">Beckman Optima Multiwavelength Analytical Ultracentrifuge</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/mw-auc-sample-preparation-guide" class="nav-link">MW-AUC Sample Preparation Guide</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/formulatrix-rock-imager-182" class="nav-link">Formulatrix Rock Imager 182</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/jansi-uv-microscope" class="nav-link">Jansi UV Microscope</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/jasco-j-1500-circular-dichroismcd-spectrometer" class="nav-link">Jasco J-1500 Circular Dichroism(CD) Spectrometer</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/lumicks-ctrap2" class="nav-link">Lumicks C-Trap2</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/nikon-smz18-research-stereomicroscope" class="nav-link">Nikon SMZ18 Research Stereomicroscope</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/nikon-smz1500-stereo-microscope-and-digital-camera" class="nav-link">Nikon SMZ1500 Stereo-Microscope and Digital Camera</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/rigaku-biosaxs-2000-2d-kratky-system" class="nav-link">Rigaku BioSAXS-2000 2D-Kratky system</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/rigaku-x-ray-crystallography-equipment" class="nav-link">Rigaku X-Ray Crystallography Equipment</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/wyatt-dynapro-nanostar-dynamic-light-scattering-instrument" class="nav-link">Wyatt DynaPro NanoStar Dynamic Light Scattering Instrument</a> </li> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/instrumentation/wyatt-sec-mals" class="nav-link">Wyatt SEC-MALS</a> </li> </ul> </div> </li> <li class="nav-item " data-slug="services"> <button class="nav-link nav-link-no-link collapsed" href="#16371" data-toggle="collapse" data-target="#16371">Services</button> <button class="nav-link collapsed" href="#16371" data-toggle="collapse" data-target="#16371"><i class="fas fa-angle-down fa-lg"></i><i class="fas fa-angle-up fa-lg"></i></button> <div class="collapse second-page " id="16371" aria-expanded="false"> <ul class="flex-column pl-0 nav"> <li class="nav-item "> <a href="https://www.huck.psu.edu/core-facilities/x-ray-crystallography-facility/services/3d-structure-determination-and-analysis" class="nav-link">3D Structure determination and analysis</a> </li> <li class="nav-item "> <a 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the Flow Cytometry Facility, and financial specialist Kelly Foster.</p> </div> </a> <a class="card" href="/core-facilities/x-ray-crystallography-facility/news/new-x-ray-crystallography-equipment-expands-research-capability" > <div class="card-body"> <h3 class="card-title">New single molecule biophysics equipment expands research capability</h3> <p class="card-text">A new addition to the Huck's instrumentation portfolio is expanding the options available to life science researchers, and uses powerful lasers as tweezers to manipulate individual molecules..</p> </div> </a> <a class="card" href="https://www.psu.edu/news/brandywine/story/undergraduate-research-may-contribute-covid-19-treatments/" > <div class="card-body"> <h3 class="card-title">Undergraduate research may contribute to COVID-19 treatments</h3> <p class="card-text">Brandywine undergraduates worked with professor to investigate potential new therapies to inhibit an enzyme that helps the coronavirus replicate</p> </div> </a> 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life science researchers, and uses powerful lasers as tweezers to manipulate individual molecules..</p> </div> </a> <a class="card" href="https://www.psu.edu/news/brandywine/story/undergraduate-research-may-contribute-covid-19-treatments/" > <div class="card-body"> <h3 class="card-title">Undergraduate research may contribute to COVID-19 treatments</h3> <p class="card-text">Brandywine undergraduates worked with professor to investigate potential new therapies to inhibit an enzyme that helps the coronavirus replicate</p> </div> </a> <a class="card" href="https://www.psu.edu/news/academics/story/core-facilities-director-brings-more-technical-advice-research/" > <div class="card-body"> <h3 class="card-title">Core facilities director brings more than technical advice to research</h3> <p class="card-text">Directors of the core facilities at Penn State’s Huck Institutes of the Life Sciences are more than expert technicians — they are also researchers in their own right. 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