Potential drugs for cancer treatment may help tackle tuberculosis

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-CYKM8FBS6G"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-CYKM8FBS6G", {"groups":"default","cookie_domain":"news.cornell.edu","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Researchers in the College of Veterinary Medicine and colleagues have discovered that a protein complex that helps fight cancer cells also slows the growth of tuberculosis – a finding that could mean better treatments for both diseases." /> <meta name="abstract" content="Researchers in the College of Veterinary Medicine and colleagues have discovered that a protein complex that helps fight cancer cells also slows the growth of tuberculosis – a finding that could mean better treatments for both diseases." /> <meta property="og:site_name" content="Cornell Chronicle" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://news.cornell.edu/stories/2024/10/potential-drugs-cancer-treatment-may-help-tackle-tuberculosis" /> <meta property="og:title" content="Potential drugs for cancer treatment may help tackle tuberculosis | Cornell Chronicle" /> <meta property="og:description" content="Researchers in the College of Veterinary Medicine and colleagues have discovered that a protein complex that helps fight cancer cells also slows the growth of tuberculosis – a finding that could mean better treatments for both diseases." /> <meta property="og:image" content="https://news.cornell.edu/sites/default/files/styles/story_thumbnail_lg/public/2024-10/1030_macrophage_tnd.png?itok=Dj48-kMC" /> <meta property="og:image:url" content="https://news.cornell.edu/sites/default/files/styles/story_thumbnail_lg/public/2024-10/1030_macrophage_tnd.png?itok=Dj48-kMC" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:description" content="Researchers in the College of Veterinary Medicine and colleagues have discovered that a protein complex that helps fight cancer cells also slows the growth of tuberculosis – a finding that could mean better treatments for both diseases." /> <meta name="twitter:site" content="@CornellNews" /> <meta name="twitter:title" content="Potential drugs for cancer treatment may help tackle tuberculosis | Cornell Chronicle" /> <meta name="twitter:image" content="https://news.cornell.edu/sites/default/files/styles/story_thumbnail_lg/public/2024-10/1030_macrophage_tnd.png?itok=Dj48-kMC" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="canonical" href="https://news.cornell.edu/stories/2024/10/potential-drugs-cancer-treatment-may-help-tackle-tuberculosis" /> <link rel="shortlink" href="https://news.cornell.edu/node/329676" /> <script>window.a2a_config=window.a2a_config||{};a2a_config.callbacks=[];a2a_config.overlays=[];a2a_config.templates={};// Wait for the page to fully load window.addEventListener('load', function() { // Get the element by all three class names var element = document.querySelector('.a2a_svg.a2a_s__default.a2a_s_twitter'); // Check if the element exists if (element) { // Hide the element by setting its display property to 'none' element.style.display = 'none'; } }); </script> <style>.a2a_button_twitter::before { content: url("https://www.cornell.edu/assets/core/social-icons/twitter-x-logo-dark.svg") !important; width: 12px !important; height: auto !important; display: block !important; margin: 0 auto !important; margin-top: 0px !important; } .addtoany_list a:not(:first-child) { margin-top: 0px !important; } </style> <title>Potential drugs for cancer treatment may help tackle tuberculosis | Cornell Chronicle</title>  <script src="https://use.typekit.net/kjk5sih.js"></script> <script>try{Typekit.load({ async: true });}catch(e){}</script>   <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/align.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/fieldgroup.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/container-inline.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/clearfix.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/details.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/hidden.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/item-list.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/js.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/nowrap.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/position-container.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/reset-appearance.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/resize.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/system-status-counter.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/system-status-report-counters.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/system-status-report-general-info.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/system/components/tablesort.module.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/contrib/stable/css/filter/filter.caption.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/modules/contrib/entity_embed/css/entity_embed.filter.caption.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/modules/contrib/addtoany/css/addtoany.css?sn7tsj" /> <link rel="stylesheet" media="all" href="https://stackpath.bootstrapcdn.com/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/modules/contrib/ds/css/ds-2col-fluid.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/modules/contrib/paragraphs/css/paragraphs.unpublished.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/chronicle/vendor/gallery/css/blueimp-gallery.min.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/chronicle/dest/style.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/chronicle/css/cwd_support_hotfix.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/chronicle/css/wa2021.css?sn7tsj" /> <link rel="stylesheet" media="all" href="/themes/chronicle/css/dx_customizations.css?sn7tsj" /> </head> <body class="node--stories"> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="layout-container"> <header role="banner"> <a href="#main" class="visually-hidden focusable skip-link" aria-label="Skip to main content" tabindex="1"> Skip to main content </a>  <form action="/search" class="cu-search" method="get" role="search" aria-label="Site Search" tabindex="-1"> <div class="container"> <input autocomplete="off" id="search-query" name="search_api_fulltext" placeholder="Search the Chronicle" required="" type="search" aria-label="Search the Chronicle"> <input type="submit" value="Submit Search" style="display: none;"> </div> </form>  <div>  <nav class="navbar navbar-45px" aria-label="Supplementary Navigation"> <div class="container"> <div class="navbar-header"> <button class="navbar-toggle collapsed" data-toggle="collapse" data-target="#subNav" aria-expanded="false"> <span class="sr-only">Toggle navigation</span> <span class="icon icon-menu"></span> </button> <span class="btn btn-primary btn-search" data-search-toggle="true" role="button" tabindex="0">Search</span> <a class="navbar-brand" id="cu-brand" href="http://cornell.edu" target="_blank"><span class="sr-only">Cornell University</span></a> </div> <div class="collapse navbar-collapse pull-right" id="subNav"> <ul class="nav navbar-nav"> <li> <a href="https://www.cornell.edu/">Cornell.edu</a> </li> <li> <a href="/media-relations" target="" rel="" data-drupal-link-system-path="node/42">Media Relations</a> </li> <li class="search" data-search-toggle="true" id="button-search-toggle" tabindex="0" role="button"><span>Search</span></li> </ul> </div> </div> </nav>  <div id="block-chronicle-branding"> <div class="brandBar"> <div class="container"> <div class="row"> <div class="col-sm-12"> <div class="cornell-lockup" data-click-action="logos"> <a class="cornell-insignia" href="http://cornell.edu"> <span class="alt-text">Cornell University</span> </a> <a class="site-brand " href="/"> <h1>Cornell Chronicle</h1> </a> </div> </div> </div> </div> </div></div>  <div class="navbar navbar-default yamm navbar-primary "> <div class="navbar-header"> <button type="button" data-toggle="collapse" data-target="#navbar-collapse-grid" class="navbar-toggle" aria-label="Hide/Show Mobile Menu"> <span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span> </button> </div> <div id="navbar-collapse-grid" class="navbar-collapse collapse" role="navigation" aria-label="Main Navigation"> <ul class="nav nav-pills nav-justified nav-container"> <li class="dropdown"> <a href="" data-toggle="dropdown" class="dropdown-toggle" aria-expanded="false" role="button">Topics</a> <ul class="dropdown-menu"><li><div class="row"> <div class="col-sm-4"><ul> <li> <a href="/categories/architecture-design" data-drupal-link-system-path="taxonomy/term/14242">Architecture & Design</a> </li> <li> <a href="/categories/arts-humanities" target="" rel="" data-drupal-link-system-path="taxonomy/term/14243">Arts & Humanities</a> </li> <li> <a href="/categories/business-economics-entrepreneurship" target="" rel="" data-drupal-link-system-path="taxonomy/term/14244">Business, Economics & Entrepreneurship</a> </li> <li> <a href="/categories/computing-information-sciences" target="" rel="">Computing & Information Sciences</a> </li> <li> <a href="/categories/energy-environment-sustainability" target="" rel="" data-drupal-link-system-path="taxonomy/term/15621">Energy, Environment & Sustainability</a> </li> </ul></div> <div class="col-sm-4"><ul> <li> <a href="/categories/food-agriculture" target="" rel="" data-drupal-link-system-path="taxonomy/term/14247">Food & Agriculture</a> </li> <li> <a href="/categories/global-reach" target="" rel="" data-drupal-link-system-path="taxonomy/term/14249">Global Reach</a> </li> <li> <a href="/categories/health-nutrition-medicine" target="" rel="" data-drupal-link-system-path="taxonomy/term/14248">Health, Nutrition & Medicine</a> </li> <li> <a href="/categories/law-government-public-policy" target="" rel="" data-drupal-link-system-path="taxonomy/term/14250">Law, Government & Public Policy</a> </li> <li> <a href="/categories/life-sciences-veterinary-medicine" target="" rel="" data-drupal-link-system-path="taxonomy/term/15056">Life Sciences & Veterinary Medicine</a> </li> </ul></div> <div class="col-sm-4"><ul> <li> <a href="/categories/physical-sciences-engineering" target="" rel="" data-drupal-link-system-path="taxonomy/term/14252">Physical Sciences & Engineering</a> </li> <li> <a href="/categories/social-behavioral-sciences" target="" rel="" data-drupal-link-system-path="taxonomy/term/14253">Social & Behavioral Sciences</a> </li> <li> <a href="/categories/coronavirus" data-drupal-link-system-path="taxonomy/term/23427">Coronavirus</a> </li> </div> </li></ul> </li> <li class="dropdown"> <a href="" data-toggle="dropdown" class="dropdown-toggle" aria-expanded="false" role="button">Campus & Community</a> <ul class="dropdown-menu"><li><div class="row"> <div class="col-sm-4"><ul> <li> <a href="/categories/news-events" target="" rel="" data-drupal-link-system-path="taxonomy/term/81">News & Events</a> </li> <li> <a href="/categories/public-engagement" target="" rel="" data-drupal-link-system-path="taxonomy/term/82">Public Engagement</a> </li> <li> <a href="/categories/new-york-city" target="" rel="" data-drupal-link-system-path="taxonomy/term/105">New York City</a> </li> <li> <a href="/categories/staff-news" data-drupal-link-system-path="taxonomy/term/85">Staff News</a> </li> <li> <a href="/photos-of-the-week" data-drupal-link-system-path="photos-of-the-week">Photos of the Week</a> </li> </ul></div> <div class="col-sm-4"><ul> <li> <a href="http://www.cornellbigred.com" target="" rel="">Big Red Sports</a> </li> <li> <a href="/categories/diversity" target="" rel="" data-drupal-link-system-path="taxonomy/term/89">Diversity</a> </li> <li> <a href="/content/cornell-remembers" target="" rel="" data-drupal-link-system-path="node/267149">In Memory</a> </li> <li> <a href="/categories/features" data-drupal-link-system-path="taxonomy/term/23708">Features</a> </li> <li> <a href="https://news.cornell.edu/categories/freedom-expression">Freedom of Expression</a> </li> </ul></div> <div class="col-sm-4"><ul> <li> <a href="/categories/nys-impact-0" target="" rel="" data-drupal-link-system-path="taxonomy/term/22456">NYS Impact</a> </li> <li> <a href="/categories/student-life" data-drupal-link-system-path="taxonomy/term/23759">Student Life</a> </li> <li> <a href="https://statements.cornell.edu">University Statements</a> </li> <li> <a href="/around-cornell" data-drupal-link-system-path="taxonomy/term/23519">Around Cornell</a> </li> </div> </li></ul> </li> <li> <a href="/archive" target="" rel="" data-drupal-link-system-path="archive">All Stories</a> </li> <li class="secondary-item"> <a href="/in-the-news" target="" rel="" class="secondary-item" data-drupal-link-system-path="in-the-news">In the News</a> </li> <li class="secondary-item"> <a href="/media-relations/tip-sheets" class="secondary-item" data-drupal-link-system-path="media-relations/tip-sheets">Expert Quotes</a> </li> <li class="secondary-item"> <a href="https://alumni.cornell.edu/cornellians/" class="secondary-item">Cornellians</a> </li> </ul> </div> </div>  </div> </header> <main id="main"> <div class="layout-content"> <div> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-chronicle-content"> <article class="node node--type-stories node--view-mode-full ds-1col clearfix container"> <div class="field field--name-dynamic-twig-fieldnode-category-identifier field--type-ds field--label-hidden field__items"> <div class="field__item"> </div> </div> <header class="expanded stories"> <h1> Potential drugs for cancer treatment may help tackle tuberculosis </h1> <h2 class="byline"> By <span><a href="mailto:cunews@cornell.edu" title="Email Elodie Smith" class="ds-1col clearfix byline-authorname">Elodie Smith</a> <div class="byline-unit"><a href="https://www.vet.cornell.edu/">College of Veterinary Medicine</a></div> </span> </h2> <span class="byline date"> <time>October 29, 2024</time> </span> </header> <span class="a2a_kit a2a_kit_size_32 addtoany_list" data-a2a-url="https://news.cornell.edu/stories/2024/10/potential-drugs-cancer-treatment-may-help-tackle-tuberculosis" data-a2a-title="Potential drugs for cancer treatment may help tackle tuberculosis"><a class="a2a_button_facebook"></a><a class="a2a_button_twitter"></a><a class="a2a_button_email"></a><a class="a2a_dd addtoany_share" href="https://www.addtoany.com/share#url=https%3A%2F%2Fnews.cornell.edu%2Fstories%2F2024%2F10%2Fpotential-drugs-cancer-treatment-may-help-tackle-tuberculosis&title=Potential%20drugs%20for%20cancer%20treatment%20may%20help%20tackle%20tuberculosis"></a></span> <div class="field field--name-body field--type-text-with-summary field--label-hidden field__items"> <div class="field__item"><p><span>Researchers have discovered that a protein complex that helps fight cancer cells also slows the growth of tuberculosis – a finding that could mean better treatments for both diseases.</span></p><p><span>The protein complex, which slows down the growth of tuberculosis (Mtb) bacteria in infected immune cells and enables them to survive infection, represents a newly discovered way human cells defend against bacterial infections.</span></p><div data-entity-type="media_embed" data-entity-uuid="7b6eca67-b3d5-4894-a1a2-842713f5e11d" data-embed-button="image_embed" data-entity-embed-display="view_mode:media_embed.image_caption" class="align-right embedded-entity width-wide" data-langcode="en" data-entity-embed-display-settings="[]"><figure> <div class="media-gallery gallery-links">  <a href="https://news.cornell.edu/sites/default/files/styles/full_size/public/2024-10/1030_macrophage.png?itok=qJsRb-wf" title="Confocal microscopy image of macrophages infected with&nbsp;tuberculosis bacteria; colors indicate bacteria health status: green bacteria are healthy, while red ones are unhealthy or dying." data-gallery="#gallery-260752" role="button" aria-haspopup="dialog"> <img loading="lazy" class="img-responsive brand-logo" src="/sites/default/files/styles/breakout/public/2024-10/1030_macrophage.png?itok=7aVxglcM" width="670" height="694" alt="Confocal microscopy image of macrophages infected with tuberculosis bacteria; colors indicate bacteria health status: green bacteria are healthy, while red ones are unhealthy or dying."> </a> <div class="byline"><span class="sr-only">Credit: </span>Russell Lab/Provided</div> </div> <figcaption><p>Confocal microscopy image of macrophages infected with<em> </em>tuberculosis bacteria; colors indicate bacteria health status: green bacteria are healthy, while red ones are unhealthy or dying.</p> </figcaption> </figure> </div> <p><span>The protein complex, GID/CTLH, was known to control the degradation of glucose in yeast. Researchers had previously targeted this complex to starve human cancer cells, which are notoriously glucose-hungry. This is the first time the GID complex has been implicated in any infection.</span></p><p><span>“The GID complex is already a focus of drug discovery in cancer, so if people are out there looking for drugs to inhibit this complex, this could mean new opportunities for treatment of TB,” said </span><a href="https://www.vet.cornell.edu/research/david-russell-phd"><span>David Russell</span></a><span>, the William Kaplan Professor of Infection Biology in the Department of Microbiology and Immunology in the College of Veterinary Medicine (CVM), and lead author of the paper.</span></p><p><span>The research, published Oct. 29 in </span><a href="https://www.nature.com/articles/s41467-024-53637-z"><span>Nature Communications</span></a><span>, was conducted with </span><a href="https://www.vet.cornell.edu/research/craig-altier-dvm-phd"><span>Dr. Craig Altier</span></a><span>, professor of population medicine and diagnostic sciences (CVM), and Christopher Sassetti, professor of microbiology at the University of Massachussets’ Chan Medical School.</span></p><p><span>The team discovered the protein complex’s role in antimicrobial defense through a screening that Nelson Simwela, a post-doctoral researcher in the Russell lab, did to find new biological targets that allow Mtb-infected cells to resist infection. To perform that screening, they used the CRISPR/Cas9 gene-editing technology to inactivate genes at random in primary macrophages, a type of immune cell. The team generated sufficient knockouts to provide extensive coverage of the full mouse genome</span></p><p><span>They then infected this macrophage population with Mtb and waited to see which macrophages died and which survived. “We waited until 50% of the macrophages had died from the infection,” Russell said. “We took the other living 50% and analyzed them as the output of our screen. The hope was to find those cells that survive through controlling bacterial growth.”</span></p><p><span>They found 259 knockout genes that promote cell survival. This list includes genes previously known to help cells resist infections, and genes that had never been associated with this function. Among these are five encoded protein subunits that form the GID complex. “With this overlap, we were confident we had hit a pathway relevant to our phenotype of interest,” Russell said.</span></p><p><span>To see if their results applied to other bacterial infections in cells, the team tested their discovery on cells infected by salmonella. Cells lacking a functional GID complex were also better at controlling salmonella growth and had a higher survival rate, indicating that their discovery was not limited to Mtb.</span></p><p><span>In parallel with the genetic screening, Russell and his team are also screening for chemicals that could mimic the effects of the GID-knockout. “Genetic screening provides scientific information but chemical screening provides starting compounds for drug development,” Russell said. “We have compounds that produce a comparable metabolic shift to the knockout and may help us develop new anti-TB drugs.”</span></p><p><span>The Russell lab is interested chemicals that reprogram macrophages to be more resistant to infection, particularly compounds that help existing drugs works better or keep working. “This is particularly important for tuberculosis because these bacteria readily become less sensitive to drugs,” he said.</span></p><p><span>Currently, other researchers are seeking chemicals that specifically affect the GID complex for cancer therapy, and Russell hopes to leverage the new findings for tuberculosis therapeutics. “We are monitoring the GID complex literature very closely,” Russell said. “If new compounds are identified, we want to plug them immediately in our tuberculosis drug discovery platform.”</span></p><p><em><span>Elodie Smith is a writer for the College of Veterinary Medicine.</span></em></p></div> </div><div class="margin-bottom margin-top margin-lg tag-blocks story-tags"> <div class="col-sm-9 story-tags-wrapper"> <div class="field field--name-field-category field--type-entity-reference field--label-hidden field__items"> <div class="field__item"><span class="taxonomy-term taxonomy-term--type-categories-main taxonomy-term--view-mode-tag-block ds-1col clearfix"> <span class="tag-block"> <a href="/categories/health-nutrition-medicine" hreflang="en">Health, Nutrition & Medicine</a> </span> </span> </div> <div class="field__item"><span class="taxonomy-term taxonomy-term--type-categories-main taxonomy-term--view-mode-tag-block ds-1col clearfix"> <span class="tag-block"> <a href="/categories/life-sciences-veterinary-medicine" hreflang="en">Life Sciences & Veterinary Medicine</a> </span> </span> </div> </div> </div> </div> <div class="col-sm-3 media-inquries-btn-wrapper"> <a href="#" class="btn btn-tertiary btn-sm btn-media-inquiries" data-toggle="#media-inquiry" role="button" aria-label="Media Inquiries">Media Inquiries <span class="icon icon-chevron-down"></span></a> </div> <div class="panel toggle clearfix" id="media-inquiry"> <div class="panel-body"> <div class="row"> <div class="row"> <div class="col-sm-12 pl-media-inquiries"> <div class="col-xs-6"> <h4>Media Contact</h4> <div class="taxonomy-term taxonomy-term--type-story-contacts taxonomy-term--view-mode-contact ds-1col clearfix"> <h5> Becka Bowyer </h5> <div class="field field--name-field-contact-email field--type-email field--label-hidden field__items"> <div class="field__item"><a href="mailto:rpb224@cornell.edu">rpb224@cornell.edu</a></div> </div> <div class="field field--name-field-contact-phone field--type-telephone field--label-hidden field__items"> <div class="field__item"><a href="tel:6072204185">6072204185</a></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix"></div> <div class="field field--name-dynamic-twig-fieldnode-subscribe-cta field--type-ds field--label-hidden field__items"> <div class="field__item"><div class="row"> <div class="col-sm-12 subscribe-wrapper"> <hr class="expanded"> <div class="subscribe-container"> <p>Get Cornell news delivered right to your inbox.</p> <a href="/about/subscribe-newsletter" class="btn btn-tertiary btn-sm btn-media-inquiries" role="button" aria-label="Subscribe">Subscribe</a> </div> </div> </div></div> </div><hr class="expanded"> <div class="stories expanded stories-you-might-like"> <div class="stories-heading "> <div class="row"> <div class="col-sm-12"> <h2>You might also like</h2> </div> </div> </div> <div class="row"> <div class="col-sm-6"> <div class="row story story-xs"> <div class="col-xs-4 story-img"> <a class="img-link" href="/stories/2024/10/new-genetic-signature-reveals-tropical-virus-move" title="New genetic signature reveals a tropical virus on the move" aria-hidden="true" tabindex="-1"> <img alt="" class="img-responsive brand-logo" src="/sites/default/files/styles/thumbnail_story_sm/public/2024-10/1025_virus_tnd.jpg?itok=qS2LPcDU" width="144" height="82" loading="lazy" /> </a> </div> <div class="col-xs-8"> <div class="h4"> <a href="/stories/2024/10/new-genetic-signature-reveals-tropical-virus-move" hreflang="en">New genetic signature reveals a tropical virus on the move</a> </div> </div> </div> </div> <div class="col-sm-6"> <div class="row story story-xs"> <div class="col-xs-4 story-img"> <a class="img-link" href="/stories/2024/07/nys-grants-veterinary-diagnostic-lab-195m-building-expansion" title="NYS grants veterinary diagnostic lab $19.5M for building expansion" aria-hidden="true" tabindex="-1"> <img alt="" class="img-responsive brand-logo" src="/sites/default/files/styles/thumbnail_story_sm/public/2024-07/0730_cvm_7_0.jpg?itok=tddTFGaQ" width="144" height="82" loading="lazy" /> </a> </div> <div class="col-xs-8"> <div class="h4"> <a href="/stories/2024/07/nys-grants-veterinary-diagnostic-lab-195m-building-expansion" hreflang="en">NYS grants veterinary diagnostic lab $19.5M for building expansion</a> </div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </main> <div id="blueimp-gallery" class="blueimp-gallery blueimp-gallery-controls" data-use-bootstrap-modal="false" data-hide-page-scrollbars="false" data-toggle-slideshow-on-space="false" data-toggle-controls-on-return="false" data-enable-keyboard-navigation="false" tabindex="-1" role="dialog" aria-modal="true" aria-label="Gallery">  <div id="modal-start" class="slides" tabindex="-1"></div>  <h3 class="title">Gallery Heading</h3> <button class="prev" value="previous" aria-label="previous"><span class="icon icon-chevron-left"></span></button> <button class="next" value="next" aria-label="next"><span class="icon icon-chevron-right"></span></button> <button class="close" value="close" aria-label="close"><span class="icon icon-close"></span></button> <button class="play-pause" value="play/pause" aria-label="play/pause"></button> <ol class="indicator"></ol>  <div class="modal fade"> <div class="modal-dialog modal-lg"> <div class="modal-content"> <div class="modal-header"> <button type="button" value="close" class="close" aria-hidden="true" aria-label="close">×</button> </div> <div class="modal-body next"></div> <div class="modal-footer"> <button type="button" value="previous" class="btn btn-default pull-left prev" aria-label="previous"> <span class="glyphicon glyphicon-chevron-left"></span> Previous </button> <button type="button" value="next" class="btn btn-primary next" aria-label="next"> Next <span class="glyphicon glyphicon-chevron-right"></span> </button> </div> </div> </div> </div> </div>  <footer> <div class="container">  <div class="row"> <div> <div class="col-sm-4"> <h2>Links</h2> <ul class="no-bullet"> <li> <a href="/about" target="" rel="" data-drupal-link-system-path="node/267141">About the Chronicle</a> </li> <li> <a href="/media-relations" data-drupal-link-system-path="node/42">Media Relations Office</a> </li> <li> <a href="/sitemap" data-drupal-link-system-path="node/324793">Sitemap</a> </li> <li> <a href="/about/copyright" target="" rel="" data-drupal-link-system-path="node/267143">Copyright</a> </li> <li> <a href="http://news.cornell.edu/web-accessibility-assistance">Web Accessibility Assistance</a> </li> <li> <a href="https://universityrelations.cornell.edu/" target="_blank">University Relations</a> </li> </ul> </div> <div class="col-sm-4"> <h2>Contact</h2> <div class="field field--name-body field--type-text-with-summary field--label-hidden field__items"> <div class="field__item"><address>Cornell Chronicle<br /> 312 College Ave<br /> Ithaca, NY 14850<br /> <a href="tel:+1607-255-4206">607-255-4206</a><br /> <span><a href="mailto:cunews@cornell.edu">cunews@cornell.edu</a></span></address> </div> </div> </div> <div class="col-sm-4"> <h2>SUBSCRIBE</h2> <ul class="no-bullet"> <li> <a href="/about/subscribe-newsletter" data-drupal-link-system-path="node/325252"><i class="fa fa-envelope" aria-hidden="true"></i> <span class="link-text">Daily and weekly newsletters</span></a> </li> <li> <a href="/rss-feeds" target="" rel="" data-drupal-link-system-path="node/267145"><i class="fa fa-rss" aria-hidden="true"></i> <span class="link-text">Feeds - RSS & JSON</span></a> </li> </ul> </div> </div> </div>  <div class="row superfooter"> <div> <div class="col-sm-12 text-right"> <a href="https://www.facebook.com/Cornell/" target="" rel="" class="btn btn-link btn-sm" aria-label="Facebook"> <span class="icon icon-hc-fw icon-facebook" role="presentation"></span> </a> <a href="https://twitter.com/cornellnews" target="" rel="" class="btn btn-link btn-sm" aria-label="Twitter"> <span class="icon icon-hc-fw icon-twitter" role="presentation"></span> </a> <a href="mailto:cunews@cornell.edu" target="" rel="" class="btn btn-link btn-sm" aria-label="Email"> <span class="icon icon-hc-fw icon-email" role="presentation"></span> </a> </div> </div> </div> </div> </footer>  </div> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/329676","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"google_analytics":{"account":"G-CYKM8FBS6G","trackOutbound":true,"trackMailto":true,"trackTel":true,"trackDownload":true,"trackDownloadExtensions":"7z|aac|arc|arj|asf|asx|avi|bin|csv|doc(x|m)?|dot(x|m)?|exe|flv|gif|gz|gzip|hqx|jar|jpe?g|js|mp(2|3|4|e?g)|mov(ie)?|msi|msp|pdf|phps|png|ppt(x|m)?|pot(x|m)?|pps(x|m)?|ppam|sld(x|m)?|thmx|qtm?|ra(m|r)?|sea|sit|tar|tgz|torrent|txt|wav|wma|wmv|wpd|xls(x|m|b)?|xlt(x|m)|xlam|xml|z|zip"},"field_group":{"html_element":{"mode":"full","context":"view","settings":{"classes":"byline","id":"","element":"h2","show_label":false,"label_element":"h3","attributes":"","effect":"none","speed":"fast"}}},"user":{"uid":0,"permissionsHash":"15e6e623bac93ccfbc8289a0137415ec85aedce7025906d538b0fb8d6f4d99b4"}}</script> <script src="/core/assets/vendor/jquery/jquery.min.js?v=3.7.1"></script> <script src="/core/misc/drupalSettingsLoader.js?v=10.3.6"></script> <script src="/core/misc/drupal.js?v=10.3.6"></script> <script src="/core/misc/drupal.init.js?v=10.3.6"></script> <script src="https://static.addtoany.com/menu/page.js" async></script> <script src="/modules/contrib/addtoany/js/addtoany.js?v=10.3.6"></script> <script src="/themes/chronicle/vendor/bootstrap/assets/javascripts/bootstrap.min.js?sn7tsj"></script> <script src="/themes/chronicle/vendor/timeago/jquery.timeago.js?sn7tsj"></script> <script src="/themes/chronicle/vendor/gallery/js/jquery.blueimp-gallery.min.js?sn7tsj"></script> <script src="/themes/chronicle/dest/script.js?sn7tsj"></script> <script src="/themes/chronicle/js/wa2021.js?sn7tsj"></script> <script src="/themes/chronicle/js/upnext.js?sn7tsj"></script> <script src="/modules/contrib/google_analytics/js/google_analytics.js?v=10.3.6"></script> <script src="/modules/custom_chronicle/chronicle_general/js/jquery.scrolldepth.min.js?v=1"></script> <script src="/modules/custom_chronicle/chronicle_general/js/chronicle_ga.js?v=1"></script> </body> </html>

CINXE.COM

Potential drugs for cancer treatment may help tackle tuberculosis | Cornell Chronicle