Institute of Metabolic Disorders

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<strong>Start</strong> </a> <li class=""> <a href="#about" class="nav_link"> <strong>About</strong> </a> <li class=""> <a href="#publications" class="nav_link"> <strong>Publications</strong> </a> <li class=""> <a href="#personnel" class="nav_link"> <strong>Personnel</strong> </a> <li class=""> <a href="#contact" class="nav_link"> <strong>Contact</strong> </a> </li> </ul> <footer> <a id="careers" href="https://us232.dayforcehcm.com/CandidatePortal/en-US/ggg/SITE/IMDCareerSite" target="_blank">Careers</a> <div id="text_links"> <a href="http://www.genesisbiotechgroup.com/legal" target="_blank">Terms of Use</a> <a href="http://www.genesisbiotechgroup.com/legal#privacy" target="_blank">Privacy Policy</a> </div> </footer> </nav> </header> <main id="content" class="group"> <section id="home" class="content" title="1"> <p id="scroll">SCROLL</p> <figure id="tagline" class="parallax"><img src="https://www.institute-metabolic-disorders.com/images/tagline.png" alt="Advancing Medicine" 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class="page_padding"> <div class="v_center parallax"> <h1>About Us</h1> <p>The Institute of Metabolic Disorders (IMD) focuses on drug discovery for the treatment of lipid-dependent fatty liver disease (NAFLD/NASH). The Institute will strive to become a respected leader in the field of metabolic disease treatment. Our goal is to increase the quality of life for individuals with metabolic pathologies associated with loss of liver function.</p> </div> </div> </section> <section id="publications" class="content" title="3"> <div class="page_padding" data-parallaxify-background-range-x="20"> <div id="data_box" data-parallaxify-range-x="90" data-parallaxify-range-y="9"> <ul id="data_menu"> <li> <a class="g_toggle" data-on="#patents_data"><span>Patents</span></a> </li> <li class="g_active"> <a class="g_toggle" data-on="#publications_data"><span>Publications</span></a> </li> </ul> <div id="data_info"> <section id="publications_data" class="toggleBox show"> <ul> <li>McCourt, P., Morgan, J., and Nickels, Jr., J.T. (2009) Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis. J. Biol. Chem. <strong>284</strong> 11930-11941 PMCID:PMC2673262</li> <li>Morgan, J., McCourt, P., Rankin, L., Swain, E., Rice, L.M., and Nickels, Jr., J.T. (2009) Altering sphingolipid metabolism in yeast cells lacking the amphiphysin ortholog, Rvs161, re-initiates sugar transporter endocytosis. <em>Eukaryot</em>. Cell 8 779-789 PMCID:PMC2681609</li> <li>Villasmil, M.L., Ansbach, A., and Nickels, Jr., J.T. (2011) The putative lipid transporter, Arv1, is required for activating pheromone-induced MAP kinase signaling in <em>Saccharomyces cerevisiae</em>. Genetics <strong>187</strong> 455-465 PMCID:PMC3030489</li> <li>Nolt, J.K., Rice, L.M., Gallo-Ebert, C., Bisher, M.E., and Nickels, Jr., J.T. (2011) PP2A<sup>Cdc55</sup> is required for multiple events during meiosis I. Cell Cycle <strong>10</strong> 1420-1434 DOI:10.4161/cc.10.9.15485</li> <li>Villasmil, M.L., and Nickels, Jr., J.T. (2011) Determination of the membrane topology of Arv1 in <em>Saccharomyces cerevisiae</em> and the requirement of the ER luminal region for Arv1 function. FEMS Yeast Res. <strong>11</strong> 524-527 DOI:10.1111/j.1567-1364.2011.00737.x</li> <li>Gallo-Ebert, C., McCourt, P.C., Donigan, M., Villasmil, M.L., Pandya, D., Franco, J., Chadwick, S.G., Gygax, S.E., and Nickels, Jr., J.T. (2012) Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi. Fungal Genetic. Biol. <strong>49</strong> 101-113 PMCID:PMC3278566</li> <li>McCourt, P., Gallo-Ebert, C., Gonhong, Y., Jiang, Y., and Joseph T. Nickels, Jr. (2013) PP2A<sup>Cdc55</sup> regulates G1 cyclin stability. Cell Cycle <strong>12</strong> 1201-1210 PMCID:PMC3674085<br>*Article featured in Cell Cycle “News and Views”. Noguchi, E (2013) PP2A<sup>Cdc55</sup>, a possible therapeutic target in cyclin D1-dependent cancers. Cell Cycle <strong>12</strong> 1484 PMCID:PMC3680526</li> <li>Gallo-Ebert, C., Donigan, M., Liu, H-Y., Pascual, F., Manners, M., Pandya, D., Swanson, R., Gallagher, D., Chen, W., Carman, G.M., Nickels, Jr., J.T. (2013) The yeast anaerobic response element AR1<sub>b</sub> regulates aerobic antifungal drug-dependent sterol gene expression. J. Biol. Chem. <strong>288</strong> 35466-35477 PMCID:PMC3853293</li> <li>Gallo-Ebert, C., Donigan, M., Stroke, I.L., Swanson, R.N., Manners, M.T., Francisco, J., Toner, G., Gallagher, D., Huang, C-Y., Gygax, S.E., Webb, M., and Nickels, Jr., J.T. (2014) Novel antifungal drug discovery based on targeting pathways regulating the fungal-conserved Upc2 transcription factor. Antimicrob. Agents and Chemother. <strong>58</strong> 258-266 PMCID:PMC3910738</li> <li>Yang, M., Liu, W., Pellicane, C., Sahyoun, C., Joseph, B., Gallo-Ebert, C., Donigan, M., Pandya, D., Giordano, C., Bata, A, and Nickels, Jr., J.T. (2014) Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low-density lipoprotein uptake. J. Lipid Res. <strong>55</strong> 226-238 PMCID:PMC3886661</li> <li>Rice, L. M., Donigan, M., Yang, M., Liu, W., Pandya, D., Joseph, B., Sodi, V., Gearhart, T. L., Yip, J., Bouchard, M. B., and Nickels, Jr., J. T. (2014) Protein phosphatase 2A regulates low-density lipoprotein uptake through regulating SREBP-2 DNA binding J. Biol. Chem. <strong>289</strong> 17268-17279 PMCID:PMC4059166</li> <li>Joseph, B., Liu, H-Y., Francisco, J., Pandya, D., Donigan, M., Gallo-Ebert, C., Giordano, C., Bata, A., Nickels, Jr., J.T. (2015) Inhibition of AMP kinase by the protein phosphatase 2A heterotrimer, PP2A<sup>Ppp2r2d</sup> J. Biol. Chem. <strong>290</strong> 10588-10598 PMCID:PMC4409226</li> <li>Pallai, R., Bhaskar, A., Burnett-Bernodat, N., Gallo-Ebert, C., Michelle Pusey, Nickels, Jr., J. T., Rice, L. M. (2015) Cancerous inhibitor of protein phosphatase 2A (CIP2A) promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin. Tumor Biol. <strong>36</strong> 6067-6074 DOI:10.1007/s13277-015-3284-7</li> <li>Pallai, R., Bhaskar, A., Burnett-Bernodat, N., Gallo-Ebert, C., Nickels, Jr., J. T., Rice, L. M. (2015) Leucine rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells. Tumor Biol. <strong>36</strong> 6368-6390 DOI:10.1007/s13277-015-3326-1</li> <li>Yang, M. and Nickels, Jr., J.T. (2015) MOGAT: A new therapeutic target for metabolic syndrome. Diseases <strong>3</strong> 179-192</li> <li>Villasmil, M. L., Francisco, J., Gallo-Ebert, C., Donigan, M., Liu, H-Y., Brower, M., and Nickels, J. T., Jr. (2016) Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle <strong>15</strong> 441-454 PMCID:PMC4943704<br>*Article featured in Cell Cycle “News and Views”. Matmati N, Kitagaki, and Hannun, YA (2016) New role for ceramide in the pheromone response. Cell Cycle <strong>15</strong> 617-618 PMCID:PMC4845927</li> <li>McCourt, P., Liu, Hsing-Yin., Parker, J.E., Gallo-Ebert, C., Donigan, M., Bata, A., Giordano, C., Kelly, SL., and Nickels, JT., Jr. (2016) Proper sterol distribution is required for Candida albicans hyphal formation and virulence. G3: Genes, Genomes, Genetics <strong>6</strong> 3455-3465 PMCID:PMC5100844</li> <li>Villasmil, M. L., Gallo-Ebert, C., Liu, H-Y., Francisco, J., and Nickels, Jr., J. T. (2017) A link between very long chain fatty acid elongation and mating-specific yeast cell cycle arrest. Cell Cycle <strong>22</strong> 2192-2203 PMCID:PMC5736334<br>*Article featured in Cell Cycle “News and Views”. Dunn, T. M., Gable, K., and Han, G., (2018) Yeast mating: Ceramide acyl chain length matters? Cell Cycle <strong>17</strong> 7-8 PMCID:PMC5815441</li> <li>Gallo-Ebert, C., Francisco, J., Liu, HY., Modi, K., Hayward, M.D., Jones, BK., Buiakova, O., McDonough, V, and Nickels, Jr., J.T. (2018) Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. J. Biol. Chem. <strong>293</strong> 5956-5974 PMCID:PMC5912475</li> <li>Nickels, Jr., J.T. (2018) New links between lipid accumulation and cancer progression. J. Biol. Chem. <strong>293</strong> 6635-6636 PMCID:PMC5925807</li> <li>Nickels, Jr., J.T. (2019) Anti-parasitic drug discovery takes a giant leap forward. (2019) J. Lipid Res. <strong>60</strong> 919-921 PMCID:PMC6495171</li> <li>Yang, M., Gallo-Ebert, C., Hayward, M., Liu, W., McDonough, V., and Nickels, Jr., J.T. <strong>2020</strong>. Human insulin growth factor 2 mRNA binding protein 2 increases miR-33a/b inhibition of liver ABCA1 expression and alters low-density apolipoprotein levels in mice. Mol. Cell. Biol. 40 e00058-20.<i> “Spotlight; Articles of Significant Interest”</i></li> <li>Villasmil, M.L., Barbosa, A.D., Cunningham, J-L., Siniossoglou, S., and Nickels, Jr., J.T. <strong>2020</strong>. An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence. PLoS ONE 15:e0235746</li> <li>Frietze KK, Brown AM, Das D, Franks RG, Cunningham JL, Hayward M, Nickels, Jr., JT. <strong>2021</strong>. Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. Autophagy. 2021 May 9:1-19. doi: 10.1080/15548627.2021.1920818. Online ahead of print. PMID: 33966599</li> <li>Trama JP, Trikannad C, Yang JJ, Adelson ME, Mordechai E. <strong>2022</strong>. High-Risk HPV Genotype Distribution According to Cervical Cytology and Age. Open Forum Infect Dis 3;9(11). PMID: 36438621.</li> </ul> </section> <section id="patents_data" class="toggleBox"> <ul> <li>Yang, G., Pellicane, C.A., and Nickels, Jr., J.T. (2016) A method of enhancing miR-185 expression to reduce low density lipoprotein/cholesterol accumulation in a cell. Patent # 9,243,250 B2</li> </ul> </section> </div> <span id="dbox_bot"></span> </div> <span id="scan_line"></span> <span id="tech_txt"></span> <div id="particles2-js" class="particles fullscreen"></div> </div> <span id="reaction" class="parallax"></span> </section> <section id="personnel" class="content" title="4"> <div class="page_padding"> <h1 class="parallax">Our Team</h1> <div id="members"> <a class="prev">Prev</a> <a class="next">next</a> <div class="frame smart" id="smart"> <ul class="items"> <li> <ul class="member_bio"> <li>Joe Nickels</li> <li>Ph.D.</li> <li>Director</li> </ul> <figure> <a href="pdfs/cv_jnickels.pdf" target="_blank" class="hitBox"></a> <img src="images/team_jnickels.png" alt="Joe Nickels" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Karla Kristine Frietze</li> <li>Ph.D.</li> <li>Research Scientist</li> </ul> <figure> <a href="pdfs/cv_kkristine.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Vidisha Raje</li> <li>Ph.D.</li> <li>Research Scientist</li> </ul> <figure> <a href="pdfs/cv_vraje.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Chris Cultrara</li> <li>Ph.D.</li> <li>Research Scientist</li> </ul> <figure> <a href="pdfs/cv_ccultrara.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Alyssa Brown</li> <li>M.S.</li> <li>Research Associate</li> </ul> <figure> <a href="pdfs/cv_abrown.pdf" target="_blank" class="hitBox"></a> <img src="images/team_abrown.png" alt="Alyssa Brown" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Suifen Lyu</li> <li>M.S.</li> <li>Research Associate</li> </ul> <figure> <a href="pdfs/cv_lyu.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Dividutta Das</li> <li>M.S.</li> <li>Research Associate</li> </ul> <figure> <a href="pdfs/cv_ddas.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Joshua D. Wayne</li> <li>M.S.</li> <li>Research Associate</li> </ul> <figure> <a href="pdfs/cv_jwayne.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Raymond Franks</li> <li>M.S.</li> <li>Research associate</li> </ul> <figure> <a href="pdfs/cv_rfranks.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> <li> <ul class="member_bio"> <li>Nicholas A. Wachowski</li> <li>M.S.</li> <li>Graduate Student</li> </ul> <figure> <a href="pdfs/cv_nwachowski.pdf" target="_blank" class="hitBox"></a> <img src="images/team_none.png" alt="" class="mxHeight"> </figure> </li> </ul> </div> </div> </div> <div id="cells" class="fullscreen"> <div class="fg fullscreen parallax" data-parallaxify-range-y="20"></div> <div class="mg fullscreen parallax" data-parallaxify-range-y="90"></div> <div class="bg fullscreen parallax" data-parallaxify-range-y="200"></div> </div> <div id="division" class="fullscreen"> <div id="cell_div" class="cell"></div> <div id="ink"></div> <div id="dna" class="fullscreen parallax"></div> </div> </section> <section id="contact" class="content" title="5"> <div class="page_padding parallax"> <div class="v_center"> <address> <h1>Contact Us</h1> <p> Institute of Metabolic Disorders<br> 1000 Waterview Drive<br> Hamilton, NJ 08690 </p> <a href="tel:+16095701015" id="phone">(609) 570–1015</a> <a id="msg_btn" class="toggle" data-on="#form"><span>Send us a message</span></a> </address> <form id="form" class="form" method="post" data-sth="contact"> <section id="f_output"> <div class="v_center form_msg">  <p class="status"></p> </div> </section> <div id="f_input"> <div class="field"> <label for="c_name">Name</label> <input type="text" id="c_name" name="c_name" class="if" required> </div> <div class="field"> <label for="c_email">Email</label> <input type="email" id="c_email" name="c_email" class="if" required> </div> <div class="field"> <label for="c_msg">Message</label> <textarea rows="4" id="c_msg" name="c_msg" class="if" required></textarea> </div> <input type="hidden" name="key_code" value="679b60d42746195f80209546bc5125c9"> <input type="hidden" class="timer" name="timer" value=""> <label style="display: block;height:0;"> <input type="text" name="catch" style="height: 100%; border:0; padding:0;"> </label> <div class="form_btns group"> <a class="cancel toggle" data-on="#form">Cancel</a> <button id="send_form" class="btn" name="send_message"> <span>Send</span> <div class="bg"> <span class="ver"></span> <span class="hor"></span> </div> </button> </div> </div> </form> </div> </div> </section> </main> </div> </body> </html>

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