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show" id="602c57133fed9e549afd791d"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/protein-symmetry">Protein Symmetry</a></td></tr></table></div><div class="item show" id="602c57603fed9e549afd791e"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/scop-e">SCOP-e</a></td></tr></table></div><div class="item show" id="6141014def055f03d1f222d4"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/scop2">SCOP2</a></td></tr></table></div><div class="item show" id="602c56f13fed9e549afd791c"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/source-organism">Source Organism</a></td></tr></table></div><div class="item show" id="6000bab4d3c1ff0cf1f44f48"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/search-and-browse/mypdb">MyPDB</a></td></tr></table></div><div class="group show" id="618271c92a7d828464a7d146" onclick="toggle("618271c92a7d828464a7d146")"><table><tr><td style="padding-left: 4px">Exploring a 3D Structure</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph618271c92a7d828464a7d146"></span></td></tr></table></div><div class="item hidden" id="618274c904fb9835c6ae189a"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/overview">Overview</a></td></tr></table></div><div class="item hidden" id="618271f904fb9835c6ae1892"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/structure-summary-page">Structure Summary Page</a></td></tr></table></div><div class="item hidden" id="6182729704fb9835c6ae1893"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/structure">Structure</a></td></tr></table></div><div class="item hidden" id="618272c004fb9835c6ae1894"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/annotations">Annotations</a></td></tr></table></div><div class="item hidden" id="618272e004fb9835c6ae1895"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/experiment">Experiment</a></td></tr></table></div><div class="item hidden" id="618272fb04fb9835c6ae1896"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/sequence">Sequence</a></td></tr></table></div><div class="item hidden" id="6182730904fb9835c6ae1897"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/genome">Genome</a></td></tr></table></div><div class="item hidden" id="6182731a04fb9835c6ae1898"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/ligands">Ligands</a></td></tr></table></div><div class="item hidden" id="6182732a04fb9835c6ae1899"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/versions">Versions</a></td></tr></table></div><div class="group show" id="6256b2b3b4396e45e97bf3de" onclick="toggle("6256b2b3b4396e45e97bf3de")"><table><tr><td style="padding-left: 4px">Grouping Structures</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph6256b2b3b4396e45e97bf3de"></span></td></tr></table></div><div class="item hidden" id="62fbafaf3b6e49562fa5c055"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/overview-grouping-structures">Overview: Grouping Structures</a></td></tr></table></div><div class="item hidden" id="6081c10aec901916050494be"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/sequence-based-clustering">Sequence-based Clustering</a></td></tr></table></div><div class="item hidden" id="6256b3269c3931864b07285b"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/grouping-search-results">Grouping Search Results</a></td></tr></table></div><div class="item hidden" id="6256b35e9c3931864b07285c"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/group-summary-pages">Group Summary Pages</a></td></tr></table></div><div class="item hidden" id="6364336066d6046810db7f11"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/explore-sequence-alignments-in-3d">Explore Sequence Alignments in 3D</a></td></tr></table></div><div class="group show" id="5fd3e3a6eb210c2c5632d098" onclick="toggle("5fd3e3a6eb210c2c5632d098")"><table><tr><td style="padding-left: 4px">3D Viewers</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5fd3e3a6eb210c2c5632d098"></span></td></tr></table></div><div class="group hidden" id="5f98cc9614cc37a34de620ea" onclick="toggle("5f98cc9614cc37a34de620ea")"><table><tr><td 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class="item hidden" id="65a4b499c76ca3abcc925d0d"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/3d-viewers/ngl-to-mol*-ui-migration-guide">NGL to Mol* UI Migration Guide</a></td></tr></table></div><div class="group show" id="5fd3e3f4eb210c2c56332c65" onclick="toggle("5fd3e3f4eb210c2c56332c65")"><table><tr><td style="padding-left: 4px">Sequence Viewers</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5fd3e3f4eb210c2c56332c65"></span></td></tr></table></div><div class="item hidden" id="60103d1ab1afe64903398251"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/sequence-annotations-viewer">Sequence Annotations Viewer</a></td></tr></table></div><div class="item hidden" id="60342ff52087e87def0d0b09"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/sequence-annotations-in-3d">Sequence Annotations in 3D</a></td></tr></table></div><div class="item hidden" id="5fc7f2843fb4b83beb6a7a3d"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/genome-view">Genome View</a></td></tr></table></div><div class="item hidden" id="60182dc1ecb9a74be53123aa"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/protein-sequence-alignment-view">Protein Sequence Alignment View</a></td></tr></table></div><div class="group show" id="60132e62aeeea33d3f095fa8" onclick="toggle("60132e62aeeea33d3f095fa8")"><table><tr><td style="padding-left: 4px">Tools</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph60132e62aeeea33d3f095fa8"></span></td></tr></table></div><div class="item hidden" id="60132e6a610d04019e01d4c2"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/tools/pairwise-structure-alignment">Pairwise Structure Alignment</a></td></tr></table></div><div class="group show" id="601024f3244a4309df5d6630" onclick="toggle("601024f3244a4309df5d6630")"><table><tr><td style="padding-left: 4px">Additional Resources</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph601024f3244a4309df5d6630"></span></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb836"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/3d-printing">3D Printing</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb839"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/databases-and-knowledgebases">Databases and Knowledgebases</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb838"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/crystallography-software">Crystallography Software</a></td></tr></table></div><div class="item hidden" id="63ee50cac031758bf1c30ff4"><table><tr><td class="title" style="padding-left: 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data-elastic-include><h5 class="menu-path">Search and Browse > Browse Options</h5><h1>Genome Location</h1><div><a class="content-anchor" id="what-is-genome-location-browser"></a> <h4>What is Genome Location Browser?</h4> <p>The genome browser is a hierarchical representation of structures from genomes of various organisms. <br /><br />RCSB PDB has mapped the structures to the chromosomal loci based on UniProtKB/GenBank accession numbers associated with the structures and the loci. The genomes represented are a subset of the genomes in the NCBI genome database and whose curated sequences for genetic loci are archived at <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene">Entrez Gene</a>. The top level in the hierarchy is the organism's genome. Each genome expands into chromosomes which in turn expand into a list of loci on the chromosomes. Each locus is a link to retrieve structures associated with it.</p> <a class="content-anchor" id="why-browse-by-genome-location"></a> <h4>Why Browse by Genome Location?</h4> <p>Here you can search for an organism's name and browse through genes in the organism by Chromosomes or gene names. You can also search the mapped structures using their names.</p> <a class="content-anchor" id="how-to-use-the-genome-location-browser"></a> <h4>How to use the <a href="/search/browse/genome_location" target="_blank">Genome Location Browser</a>?</h4> <p>This browser combines two different ways of organizing polymer entities - by organism and by position of the gene of interest in a chromosome.</p> <ul style="list-style-type:disc;"> <li>You can search for a specific gene by its name and find the first instance of it in any organism included in the browser.</li> <li>If you are looking for a gene in a specific organism you can first search for the organism by its name and then </li> <ul style="list-style-type:disc;"> <li>browse through all the chromosomes to find the gene of interest, OR</li> <li>find the chromosome number on which the gene of interest is located and browse the relevant chromosome. To find the chromosome number where the gene of interest is located you can search for the organism and gene name in the <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene">Entrez Gene</a> website. </li> </ul> </ul> <div style="height: 20px;"></div><p>Once you have identified a gene of interest in the organism of your choice, you can view the number of associated polymer entities in the PDB, and select from them the ones to explore.</p> <a class="content-anchor" id="examples"></a> <h4>Examples</h4> <p>1. Search for TEM-1 Class A Broad Spectrum beta-lactamase protein in <i>E. coli</i></p> <ul style="list-style-type:disc;"> <li>Type the name of the organism "<i>Escherichia coli</i>" or "(<i>E. coli</i>) " in the search box at the top of the page and click on search</li> <li>Scroll down the page to where the selected organism is highlighted in the browse tree - click on the arrowhead (triangle) next to the organism name to open the genes listed under it.</li> <li>The numbers listed next to the gene name (<b>class A broad-spectrum beta-lactamase TEM-1</b>) indicate the number of polymer entities that match the gene name. Clicking on it will launch a search for all polymer entities in the PDB that are associated with the organism and gene name.</li> </ul> <div style="height: 20px;"></div><p>2. Search for <b>Cadherin 1</b> in <i>Homo sapiens</i></p> <ul style="list-style-type:disc;"> <li>Type the name of the organism "<i>Homo sapiens</i>" in the search box at the top of the page and click on search</li> <li>Scroll down the page to where the selected organism is highlighted in the browse tree - click on the arrowhead (triangle) next to the organism name to open the chromosomes listed under it.</li> <li>To find out the chromosome that includes the gene of interest, do a quick check in the <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene">Entrez Gene</a> website on a new browser window or tab. Open this page and type "Homo sapiens cadherin 1" in the top search box. Scan the page showing the results of the search and note the chromosome number (16) on which the gene is located. </li> <li>Come back RCSB page where you have the Genome Location Browser open and click on the arrowhead (triangle) next to the <b>Chromosome 16</b> to view the genes listed under it. Note only genes whose proteins are present in the PDB are listed here. </li> <li>The numbers listed next to the gene name (<b>Cadherin 1</b>) indicate the number of polymer entities that match the gene name. Clicking on it will launch a search for all polymer entities in the PDB that are associated with the organism and gene name.</li> </ul> <div style="height: 20px;"></div></div></div><br><hr><div class="item-info"><div>Please report any encountered broken links to <a href='mailto:info@rcsb.org'>info@rcsb.org</a></div><div>Last updated: 6/25/2024</div></div></div></div></div></div><div data-elastic-exclude><div class="hidden-print" id="footer_main"><div class="container" style="padding:0"><div class="row"><div class="col-md-6 col-sm-12" style="padding-left:0"> <div class="row"><div class="col-sm-4"><ul><li><span class="row_header">About</span></li><li><a href="/pages/about-us/index">About Us</a></li><li><a href="/pages/policies#References">Citing Us</a></li><li><a href="/pages/publications">Publications</a></li><li><a href="/pages/team">Team</a></li><li><a href="/pages/jobs">Careers</a></li><li><a href="/pages/policies">Usage & Privacy</a></li></ul></div><div class="col-sm-4" style="padding-left:0"><ul><li><span class="row_header">Support</span></li><li><a href="/pages/contactus">Contact Us</a></li><li><a href="/help">Help</a></li><li><a href="/docs/general-help/website-faq">Website FAQ</a></li><li><a href="/docs/general-help/glossary">Glossary</a></li><li><a href="https://status.rcsb.org/" target="_blank">Service Status</a></li></ul></div><div class="col-md-4 hidden-sm"></div></div></div><div class="col-md-6 col-sm-12" style="padding-left:5px"> <div class="row"><div class="col-sm-4"><p class="row_header">RCSB PDB is hosted by</p><div class="footerLogos"><hr><a href="http://www.rutgers.edu/"><img class="Rutgerslogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_Rutgers-2024.png" alt="Rutgers University logo"></a><hr><a href="https://ucsd.edu/"><img class="UCSDlogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_UCSD-navy.png" alt="Uiversity of California San Diego logo"></a><a href="https://www.sdsc.edu/"><img class="SDSClogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_SDSC-black.png" alt="San Diego Supercomputer Center logo"></a><hr><a href="https://www.ucsf.edu/"><img class="UCSFlogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_UCSF.png" alt="University of California San Francisco Logo"></a></div></div><div class="col-sm-4"><p class="row_header">RCSB PDB is a member of the</p><div class="footerLogos"><span id="pdbmembers_footer"><hr><a href="https://www.wwpdb.org" target="_blank" rel="noopener"><img class="wwpdblogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_wwpdb.png" alt="wwPDB"></a><hr><a href="https://www.emdataresource.org" target="_blank" rel="noopener"><img id="emdatabanklogo_footer" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/EMDataResourcelogo.png" alt="EMDataResource"></a></span></div></div><div class="col-sm-4"><ul><li><span class="row_header">RCSB Partners</span></li><li><a href="https://nakb.org/" target="_blank" rel="noopener">Nucleic Acid Knowledgebase</a></li></ul><ul><li><span class="row_header"><a href="https://www.wwpdb.org/" target="_blank" rel="noopener" style="text-decoration: none; color: black">wwPDB Partners</a></span></li><li><a href="/">RCSB PDB</a></li><li><a href="https://www.ebi.ac.uk/pdbe/" target="_blank" rel="noopener">PDBe</a></li><li><a href="https://www.pdbj.org/" target="_blank" rel="noopener">PDBj</a></li><li><a href="https://bmrb.io/" target="_blank" rel="noopener">BMRB</a></li><li><a href="https://emdb-empiar.org/" target="_blank" rel="noopener">EMDB</a></li></ul></div></div></div></div></div></div><div id="footer_grant"><div class="container"><div class="row"><p>RCSB PDB Core Operations are funded by the <a href="http://www.nsf.gov/" target="_blank" rel="noopener">U.S. National Science Foundation</a> (DBI-2321666), the <a href="http://science.energy.gov/" target="_blank" rel="noopener">US Department of Energy</a> (DE-SC0019749), and the <a href="http://www.cancer.gov/" target="_blank" rel="noopener">National Cancer Institute</a>, <a href="http://www.niaid.nih.gov/" target="_blank" rel="noopener">National Institute of Allergy and Infectious Diseases</a>, and <a href="http://www.nigms.nih.gov/" target="_blank" rel="noopener">National Institute of General Medical Sciences</a> of the <a href="http://www.nih.gov/" target="_blank" rel="noopener">National Institutes of Health</a> under grant R01GM157729.</p></div></div></div><div id="jira-fdbck"></div></div></div></body></html>