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Candida albicans - Wikipedia
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vector-toc-level-2"> <a class="vector-toc-link" href="#High-frequency_switching"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>High-frequency switching</span> </div> </a> <ul id="toc-High-frequency_switching-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-White-opaque_switching" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#White-opaque_switching"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>White-opaque switching</span> </div> </a> <ul id="toc-White-opaque_switching-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Environmental_stress" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Environmental_stress"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.4</span> <span>Environmental stress</span> </div> </a> <ul id="toc-Environmental_stress-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-White-GUT_switch" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#White-GUT_switch"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.5</span> <span>White-GUT switch</span> </div> </a> <ul id="toc-White-GUT_switch-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Role_in_disease" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Role_in_disease"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Role in disease</span> </div> </a> <button aria-controls="toc-Role_in_disease-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Role in disease subsection</span> </button> <ul id="toc-Role_in_disease-sublist" class="vector-toc-list"> <li id="toc-Superficial_and_local_infections" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Superficial_and_local_infections"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Superficial and local infections</span> </div> </a> <ul id="toc-Superficial_and_local_infections-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Systemic_infections" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Systemic_infections"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Systemic infections</span> </div> </a> <ul id="toc-Systemic_infections-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_of_C._albicans_in_Crohn's_disease" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Role_of_C._albicans_in_Crohn's_disease"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Role of <i>C. albicans</i> in Crohn's disease</span> </div> </a> <ul id="toc-Role_of_C._albicans_in_Crohn's_disease-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Diagnosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Diagnosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.4</span> <span>Diagnosis</span> </div> </a> <ul id="toc-Diagnosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Treatment" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Treatment"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.5</span> <span>Treatment</span> </div> </a> <ul id="toc-Treatment-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Economic_implications" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Economic_implications"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.6</span> <span>Economic implications</span> </div> </a> <ul id="toc-Economic_implications-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_of_GSDMD_in_C.albicans_infection" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Role_of_GSDMD_in_C.albicans_infection"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.7</span> <span>Role of GSDMD in C.albicans infection</span> </div> </a> <ul id="toc-Role_of_GSDMD_in_C.albicans_infection-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Biofilm_development" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Biofilm_development"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Biofilm development</span> </div> </a> <button aria-controls="toc-Biofilm_development-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Biofilm development subsection</span> </button> <ul id="toc-Biofilm_development-sublist" class="vector-toc-list"> <li id="toc-Biofilm_formation_steps" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Biofilm_formation_steps"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Biofilm formation steps</span> </div> </a> <ul id="toc-Biofilm_formation_steps-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Zap1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Zap1"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Zap1</span> </div> </a> <ul id="toc-Zap1-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Zinc" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Zinc"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.3</span> <span>Zinc</span> </div> </a> <ul id="toc-Zinc-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Mechanisms_and_proteins_important_for_pathogenesis" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Mechanisms_and_proteins_important_for_pathogenesis"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Mechanisms and proteins important for pathogenesis</span> </div> </a> <button aria-controls="toc-Mechanisms_and_proteins_important_for_pathogenesis-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Mechanisms and proteins important for pathogenesis subsection</span> </button> <ul id="toc-Mechanisms_and_proteins_important_for_pathogenesis-sublist" class="vector-toc-list"> <li id="toc-Filamentation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Filamentation"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Filamentation</span> </div> </a> <ul id="toc-Filamentation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Hwp1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Hwp1"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Hwp1</span> </div> </a> <ul id="toc-Hwp1-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Slr1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Slr1"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Slr1</span> </div> </a> <ul id="toc-Slr1-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Candidalysin" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Candidalysin"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.4</span> <span>Candidalysin</span> </div> </a> <ul id="toc-Candidalysin-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-PRA1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#PRA1"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.5</span> <span>PRA1</span> </div> </a> <ul id="toc-PRA1-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Genetic_and_genomic_tools" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Genetic_and_genomic_tools"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Genetic and genomic tools</span> </div> </a> <button aria-controls="toc-Genetic_and_genomic_tools-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Genetic and genomic tools subsection</span> </button> <ul id="toc-Genetic_and_genomic_tools-sublist" class="vector-toc-list"> <li id="toc-Selection_markers" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Selection_markers"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Selection markers</span> </div> </a> <ul id="toc-Selection_markers-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Full_sequence_genome" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Full_sequence_genome"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Full sequence genome</span> </div> </a> <ul id="toc-Full_sequence_genome-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-ORFeome_project" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#ORFeome_project"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.3</span> <span>ORFeome project</span> </div> </a> <ul id="toc-ORFeome_project-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-CIp10_integrative_plasmid" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#CIp10_integrative_plasmid"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.4</span> <span>CIp10 integrative plasmid</span> </div> </a> <ul id="toc-CIp10_integrative_plasmid-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Candida_two-hybrid_(C2H)_system" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Candida_two-hybrid_(C2H)_system"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.5</span> <span>Candida two-hybrid (C2H) system</span> </div> </a> <ul id="toc-Candida_two-hybrid_(C2H)_system-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bimolecular_fluorescence_complementation_(BiFC)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Bimolecular_fluorescence_complementation_(BiFC)"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.6</span> <span>Bimolecular fluorescence complementation (BiFC)</span> </div> </a> <ul id="toc-Bimolecular_fluorescence_complementation_(BiFC)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Microarrays" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Microarrays"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.7</span> <span>Microarrays</span> </div> </a> <ul id="toc-Microarrays-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-GRACE_library" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#GRACE_library"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.8</span> <span>GRACE library</span> </div> </a> <ul id="toc-GRACE_library-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-CRISPR/Cas9" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#CRISPR/Cas9"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.9</span> <span>CRISPR/Cas9</span> </div> </a> <ul id="toc-CRISPR/Cas9-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Application_in_engineering" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Application_in_engineering"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Application in engineering</span> </div> </a> <ul id="toc-Application_in_engineering-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Notable_C._albicans_researchers" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Notable_C._albicans_researchers"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Notable <i>C. albicans</i> researchers</span> </div> </a> <ul id="toc-Notable_C._albicans_researchers-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">12</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">13</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><i>Candida albicans</i></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 41 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-41" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">41 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%A8%D9%8A%D8%B6%D8%A9_%D8%A8%D9%8A%D8%B6%D8%A7%D8%A1" title="مبيضة بيضاء – Arabic" lang="ar" hreflang="ar" data-title="مبيضة بيضاء" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bjn mw-list-item"><a href="https://bjn.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Banjar" lang="bjn" hreflang="bjn" data-title="Candida albicans" data-language-autonym="Banjar" data-language-local-name="Banjar" class="interlanguage-link-target"><span>Banjar</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Bulgarian" lang="bg" hreflang="bg" data-title="Candida albicans" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Bosnian" lang="bs" hreflang="bs" data-title="Candida albicans" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Catalan" lang="ca" hreflang="ca" data-title="Candida albicans" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-ceb mw-list-item"><a href="https://ceb.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Cebuano" lang="ceb" hreflang="ceb" data-title="Candida albicans" data-language-autonym="Cebuano" data-language-local-name="Cebuano" class="interlanguage-link-target"><span>Cebuano</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Czech" lang="cs" hreflang="cs" data-title="Candida albicans" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Danish" lang="da" hreflang="da" data-title="Candida albicans" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – German" lang="de" hreflang="de" data-title="Candida albicans" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Estonian" lang="et" hreflang="et" data-title="Candida albicans" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Greek" lang="el" hreflang="el" data-title="Candida albicans" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Spanish" lang="es" hreflang="es" data-title="Candida albicans" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Esperanto" lang="eo" hreflang="eo" data-title="Candida albicans" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Basque" lang="eu" hreflang="eu" data-title="Candida albicans" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D8%A7%D9%86%D8%AF%DB%8C%D8%AF%D8%A7_%D8%A2%D9%84%D8%A8%DB%8C%DA%A9%D8%A7%D9%86%D8%B3" title="کاندیدا آلبیکانس – Persian" lang="fa" hreflang="fa" data-title="کاندیدا آلبیکانس" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – French" lang="fr" hreflang="fr" data-title="Candida albicans" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Irish" lang="ga" hreflang="ga" data-title="Candida albicans" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Galician" lang="gl" hreflang="gl" data-title="Candida albicans" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Indonesian" lang="id" hreflang="id" data-title="Candida albicans" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Italian" lang="it" hreflang="it" data-title="Candida albicans" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Hebrew" lang="he" hreflang="he" data-title="Candida albicans" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Hungarian" lang="hu" hreflang="hu" data-title="Candida albicans" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/%D9%85%D8%A8%D9%8A%D8%B6%D9%87_%D8%A8%D9%8A%D8%B6%D8%A7%D8%A1" title="مبيضه بيضاء – Egyptian Arabic" lang="arz" hreflang="arz" data-title="مبيضه بيضاء" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Dutch" lang="nl" hreflang="nl" data-title="Candida albicans" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Tr%C3%B8skegj%C3%A6r" title="Trøskegjær – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Trøskegjær" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Trauskegj%C3%A6r" title="Trauskegjær – Norwegian Nynorsk" lang="nn" hreflang="nn" data-title="Trauskegjær" data-language-autonym="Norsk nynorsk" data-language-local-name="Norwegian Nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Polish" lang="pl" hreflang="pl" data-title="Candida albicans" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Portuguese" lang="pt" hreflang="pt" data-title="Candida albicans" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Russian" lang="ru" hreflang="ru" data-title="Candida albicans" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Simple English" lang="en-simple" hreflang="en-simple" data-title="Candida albicans" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Slovenian" lang="sl" hreflang="sl" data-title="Candida albicans" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%DA%A9%D8%A7%D9%86%D8%AF%DB%8C%D8%AF%D8%A7_%D8%A6%DB%95%D9%84%D8%A8%DB%8C%DA%A9%D8%A7%D9%86%D8%B3" title="کاندیدا ئەلبیکانس – Central Kurdish" lang="ckb" hreflang="ckb" data-title="کاندیدا ئەلبیکانس" data-language-autonym="کوردی" data-language-local-name="Central Kurdish" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Serbian" lang="sr" hreflang="sr" data-title="Candida albicans" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Finnish" lang="fi" hreflang="fi" data-title="Candida albicans" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Swedish" lang="sv" hreflang="sv" data-title="Candida albicans" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Thai" lang="th" hreflang="th" data-title="Candida albicans" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Turkish" lang="tr" hreflang="tr" data-title="Candida albicans" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Ukrainian" lang="uk" hreflang="uk" data-title="Candida albicans" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Candida_albicans" title="Candida albicans – Vietnamese" lang="vi" hreflang="vi" 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class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Species of fungus</div> <p class="mw-empty-elt"> </p> <table class="infobox biota" style="text-align: left; width: 200px; font-size: 100%"> <tbody><tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(145,250,250)"><i>Candida albicans</i> </th></tr> <tr> <td colspan="2" style="text-align: center"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:SEM_of_C_albicans.tif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/SEM_of_C_albicans.tif/lossy-page1-220px-SEM_of_C_albicans.tif.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/SEM_of_C_albicans.tif/lossy-page1-330px-SEM_of_C_albicans.tif.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a8/SEM_of_C_albicans.tif/lossy-page1-440px-SEM_of_C_albicans.tif.jpg 2x" data-file-width="1024" data-file-height="768" /></a></span> </td></tr> <tr> <td colspan="2" style="text-align: center; font-size: 88%"><i>Candida albicans</i> visualized using scanning electron microscopy. Note the abundant hyphal mass. </td></tr> <tr> <th colspan="2" style="color:inherit; min-width:15em; text-align: center; background-color: rgb(145,250,250)"><a href="/wiki/Taxonomy_(biology)" title="Taxonomy (biology)">Scientific classification</a> <span class="plainlinks taxobox-edit-taxonomy skin-invert" style="font-size:smaller; float:right; padding-right:0.4em; margin-left:-3em;"><span typeof="mw:File"><a href="/wiki/Template:Taxonomy/Candida" title="Edit this classification"><img alt="Edit this classification" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/15px-OOjs_UI_icon_edit-ltr.svg.png" decoding="async" width="15" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/23px-OOjs_UI_icon_edit-ltr.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr.svg/30px-OOjs_UI_icon_edit-ltr.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span> </th></tr> <tr> <td>Domain: </td> <td><a href="/wiki/Eukaryote" title="Eukaryote">Eukaryota</a> </td></tr> <tr> <td>Kingdom: </td> <td><a href="/wiki/Fungus" title="Fungus">Fungi</a> </td></tr> <tr> <td>Division: </td> <td><a href="/wiki/Ascomycota" title="Ascomycota">Ascomycota</a> </td></tr> <tr> <td>Class: </td> <td><a href="/wiki/Saccharomycetes" title="Saccharomycetes">Saccharomycetes</a> </td></tr> <tr> <td>Order: </td> <td><a href="/wiki/Saccharomycetales" title="Saccharomycetales">Saccharomycetales</a> </td></tr> <tr> <td>Family: </td> <td><a href="/wiki/Saccharomycetaceae" title="Saccharomycetaceae">Saccharomycetaceae</a> </td></tr> <tr> <td>Genus: </td> <td><a href="/wiki/Candida_(fungus)" title="Candida (fungus)"><i>Candida</i></a> </td></tr> <tr> <td>Species: </td> <td><div style="display:inline" class="species"><i><b>C. albicans</b></i></div> </td></tr> <tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(145,250,250)"><a href="/wiki/Binomial_nomenclature" title="Binomial nomenclature">Binomial name</a> </th></tr> <tr> <td colspan="2" style="text-align: center"><b><span class="binomial"><span style="font-weight:normal;"></span><i>Candida albicans</i></span></b><br /><div style="font-size: 85%;">(<a href="/wiki/Charles-Philippe_Robin" title="Charles-Philippe Robin">C.-P. Robin</a>) <a href="/wiki/Christine_Marie_Berkhout" title="Christine Marie Berkhout">Berkhout</a> (1923)</div> </td></tr> <tr> <th colspan="2" style="color:inherit; text-align: center; background-color: rgb(145,250,250)"><a href="/wiki/Synonym_(taxonomy)" title="Synonym (taxonomy)">Synonyms</a> </th></tr> <tr> <td colspan="2" style="text-align: left"> <ul><li><i>Candida stellatoidea</i><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li><i>Monilia albicans</i><sup id="cite_ref-The_yeasts_2-0" class="reference"><a href="#cite_note-The_yeasts-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li><i>Oidium albicans</i><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></li> <li>and many others.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li></ul> </td></tr> </tbody></table><style data-mw-deduplicate="TemplateStyles:r1238732961">@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox.biota tr{background:transparent!important}html.skin-theme-clientpref-night .mw-parser-output .infobox.biota img{background:transparent}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox.biota tr{background:transparent!important}html.skin-theme-clientpref-os .mw-parser-output .infobox.biota img{background:white}}.mw-parser-output .infobox.biota .taxobox-edit-taxonomy img{background:transparent!important}body.skin-vector .mw-parser-output table.biota.infobox{margin-top:0.5em}body.skin--responsive .mw-parser-output table.biota.infobox tr.taxonrow td{padding:2px 10px}</style> <p><i><b>Candida albicans</b></i> is an opportunistic <a href="/wiki/Pathogenic_yeast" class="mw-redirect" title="Pathogenic yeast">pathogenic yeast</a><sup id="cite_ref-Gow2017_5-0" class="reference"><a href="#cite_note-Gow2017-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> that is a common member of the human <a href="/wiki/Gut_flora" class="mw-redirect" title="Gut flora">gut flora</a>. It can also survive outside the human body.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults.<sup id="cite_ref-Kerawala_2010_8-0" class="reference"><a href="#cite_note-Kerawala_2010-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SIFO_9-0" class="reference"><a href="#cite_note-SIFO-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> It is usually a <a href="/wiki/Commensal" class="mw-redirect" title="Commensal">commensal</a> organism, but it can become <a href="/wiki/Pathogen" title="Pathogen">pathogenic</a> in <a href="/wiki/Immunodeficiency" title="Immunodeficiency">immunocompromised</a> individuals under a variety of conditions.<sup id="cite_ref-SIFO_9-1" class="reference"><a href="#cite_note-SIFO-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24789109_10-0" class="reference"><a href="#cite_note-pmid24789109-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> It is one of the few species of the genus <i><a href="/wiki/Candida_(fungus)" title="Candida (fungus)">Candida</a></i> that cause the human infection <a href="/wiki/Candidiasis" title="Candidiasis">candidiasis</a>, which results from an overgrowth of the fungus.<sup id="cite_ref-SIFO_9-2" class="reference"><a href="#cite_note-SIFO-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24789109_10-1" class="reference"><a href="#cite_note-pmid24789109-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Candidiasis is, for example, often observed in <a href="/wiki/HIV" title="HIV">HIV</a>-infected patients.<sup id="cite_ref-Calderone_11-0" class="reference"><a href="#cite_note-Calderone-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <i>C. albicans</i> is the most common fungal species isolated from <a href="/wiki/Biofilm" title="Biofilm">biofilms</a> either formed on (permanent) implanted medical devices or on human <a href="/wiki/Tissue_(biology)" title="Tissue (biology)">tissue</a>.<sup id="cite_ref-Kumamoto2002_12-0" class="reference"><a href="#cite_note-Kumamoto2002-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Donlan2001_13-0" class="reference"><a href="#cite_note-Donlan2001-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> <i>C. albicans</i>, <a href="/wiki/Candida_tropicalis" title="Candida tropicalis"><i>C. tropicalis</i></a>, <a href="/wiki/Candida_parapsilosis" title="Candida parapsilosis"><i>C. parapsilosis</i></a>, and <a href="/wiki/Candida_glabrata" class="mw-redirect" title="Candida glabrata"><i>C. glabrata</i></a> are together responsible for 50–90% of all cases of candidiasis in humans.<sup id="cite_ref-pmid24789109_10-2" class="reference"><a href="#cite_note-pmid24789109-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Pfaller_14-0" class="reference"><a href="#cite_note-Pfaller-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> A mortality rate of 40% has been reported for patients with systemic candidiasis due to <i>C. albicans</i>.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> By one estimate, invasive candidiasis contracted in a hospital causes 2,800 to 11,200 deaths yearly in the US.<sup id="cite_ref-Pfaller_14-1" class="reference"><a href="#cite_note-Pfaller-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Nevertheless, these numbers may not truly reflect the true extent of damage this organism causes, given new studies indicating that <i>C. albicans</i> can cross the <a href="/wiki/Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood–brain barrier</a> in mice.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p><p><i>C. albicans</i> is commonly used as a <a href="/wiki/Model_organism" title="Model organism">model organism</a> for fungal pathogens.<sup id="cite_ref-Kabir_19-0" class="reference"><a href="#cite_note-Kabir-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> It is generally referred to as a <a href="/wiki/Dimorphic_fungus" title="Dimorphic fungus">dimorphic fungus</a> since it grows both as <a href="/wiki/Yeast" title="Yeast">yeast</a> and <a href="/wiki/Hypha" title="Hypha">filamentous</a> cells. However, it has several different <a href="#Morphology">morphological</a> phenotypes including opaque, GUT, and pseudohyphal forms.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> <i>C. albicans</i> was for a long time considered an obligate diploid organism without a haploid stage. This is, however, not the case. Next to a haploid stage <i>C. albicans</i> can also exist in a tetraploid stage. The latter is formed when diploid <i>C. albicans</i> cells mate when they are in the opaque form.<sup id="cite_ref-Hickman_22-0" class="reference"><a href="#cite_note-Hickman-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> The diploid genome size is approximately 29 Mb, and up to 70% of the protein coding genes have not yet been characterized.<sup id="cite_ref-candidagenome.org_23-0" class="reference"><a href="#cite_note-candidagenome.org-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> <i>C. albicans</i> is easily cultured in the lab and can be studied both <i>in vivo</i> and <i>in vitro</i>. Depending on the media different studies can be done as the media influences the morphological state of <i>C. albicans</i>. A special type of medium is CHROMagar <i>Candida</i>, which can be used to identify different <i>Candida</i> species.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Etymology">Etymology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=1" title="Edit section: Etymology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>"<i>Candida albicans</i>" can be read as <a href="/wiki/Tautology_(language)" title="Tautology (language)">tautological</a>. "<a href="https://en.wiktionary.org/wiki/Candida#Etymology" class="extiw" title="wikt:Candida">Candida</a>" comes from the Latin word "<a href="https://en.wiktionary.org/wiki/candidus#Adjective" class="extiw" title="wikt:candidus">candidus</a>", meaning "shining white". "<a href="https://en.wiktionary.org/wiki/albicans#Etymology" class="extiw" title="wikt:albicans">Albicans</a> itself is the present participle of the Latin word "<a href="https://en.wiktionary.org/wiki/albico#Verb" class="extiw" title="wikt:albico">albicō</a>", meaning "becoming white". This leads to one possible interpretation as the redundant phrase "pure white becoming white".<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (August 2022)">citation needed</span></a></i>]</sup> </p><p>It is often shortly referred to as thrush, candidiasis, or candida. More than a hundred synonyms have been used to describe <i>C. albicans</i>.<sup id="cite_ref-The_yeasts_2-1" class="reference"><a href="#cite_note-The_yeasts-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> Over 200 species have been described within the candida genus. The oldest reference to thrush, most likely caused by <i>C. albicans</i>, dates back to 400 BC in <a href="/wiki/Hippocrates" title="Hippocrates">Hippocrates</a>' work <i>Of the Epidemics</i> describing oral candidiasis.<sup id="cite_ref-The_yeasts_2-2" class="reference"><a href="#cite_note-The_yeasts-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Genome">Genome</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=2" title="Edit section: Genome"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Candida_Gram_stain.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Candida_Gram_stain.jpg/220px-Candida_Gram_stain.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Candida_Gram_stain.jpg/330px-Candida_Gram_stain.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Candida_Gram_stain.jpg/440px-Candida_Gram_stain.jpg 2x" data-file-width="6000" data-file-height="4000" /></a><figcaption><i>Candida albicans</i> visualized by Gram stain and microscopy. Note the hyphae and chlamydospores, which are 2–4 μm in diameter.</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Candida_albicans_PHIL_3192_lores.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Candida_albicans_PHIL_3192_lores.jpg/220px-Candida_albicans_PHIL_3192_lores.jpg" decoding="async" width="220" height="147" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Candida_albicans_PHIL_3192_lores.jpg/330px-Candida_albicans_PHIL_3192_lores.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Candida_albicans_PHIL_3192_lores.jpg/440px-Candida_albicans_PHIL_3192_lores.jpg 2x" data-file-width="3072" data-file-height="2048" /></a><figcaption><i>Candida albicans</i> growing on <a href="/wiki/Sabouraud_agar" title="Sabouraud agar">Sabouraud agar</a></figcaption></figure> <p>The genome of <i>C. albicans</i> is almost 16Mb for the haploid size (28Mb for the diploid stage) and consists of 8 sets of chromosome pairs called chr1A, chr2A, chr3A, chr4A, chr5A, chr6A, chr7A and chrRA. The second set (<i>C. albicans</i> is diploid) has similar names but with a B at the end. Chr1B, chr2B, ... and chrRB. The whole genome contains 6,198 <a href="/wiki/Open_reading_frame" title="Open reading frame">open reading frames</a> (ORFs). Seventy percent of these ORFs have not yet been characterized. The whole genome has been sequenced making it one of the first fungi to be completely sequenced (next to <i>Saccharomyces cerevisiae</i> and <i>Schizosaccharomyces pombe</i>).<sup id="cite_ref-Calderone_11-1" class="reference"><a href="#cite_note-Calderone-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-candidagenome.org_23-1" class="reference"><a href="#cite_note-candidagenome.org-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> All open reading frames (ORFs) are also available in <a href="/wiki/Gateway_Technology" title="Gateway Technology">Gateway-adapted vectors</a>. Next to this ORFeome there is also the availability of a GRACE (gene replacement and conditional expression) library to study essential genes in the genome of <i>C. albicans</i>.<sup id="cite_ref-Large-scale_essential_gene_identifi_28-0" class="reference"><a href="#cite_note-Large-scale_essential_gene_identifi-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReferenceB_29-0" class="reference"><a href="#cite_note-ReferenceB-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> The most commonly used strains to study <i>C. albicans</i> are the WO-1 and SC5314 strains. The WO-1 strain is known to switch between white-opaque form with higher frequency while the SC5314 strain is the strain used for gene sequence reference.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p><p>One of the most important features of the <i>C. albicans</i> genome is the high heterozygosity. At the base of this heterozygosity lies the occurrence of numeric and structural <a href="/wiki/Chromosome" title="Chromosome">chromosomal</a> rearrangements and changes as means of generating genetic diversity by chromosome length polymorphisms (contraction/expansion of repeats), reciprocal <a href="/wiki/Chromosomal_translocation" title="Chromosomal translocation">translocations</a>, chromosome <a href="/wiki/Deletion_(genetics)" title="Deletion (genetics)">deletions</a>, Nonsynonymous <a href="/wiki/Single-nucleotide_polymorphism" title="Single-nucleotide polymorphism">single-nucleotide polymorphisms</a> and <a href="/wiki/Trisomy" title="Trisomy">trisomy</a> of individual chromosomes. These <a href="/wiki/Karyotype" title="Karyotype">karyotypic</a> alterations lead to changes in the phenotype, which is an <a href="/wiki/Adaptation" title="Adaptation">adaptation</a> strategy of this fungus. These mechanisms are further being explored with the availability of the complete analysis of the <i>C. albicans</i> genome.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>An unusual feature of the genus <i>Candida</i> is that in many of its species (including <i>C. albicans</i> and <i>C. tropicalis</i>, but not, for instance, <i>C. glabrata</i>) the CUG <a href="/wiki/Genetic_code" title="Genetic code">codon</a>, which normally specifies leucine, specifies serine in these species. This is an unusual example of a departure from the standard <a href="/wiki/Genetic_code" title="Genetic code">genetic code</a>, and most such departures are in <a href="/wiki/Start_codon" title="Start codon">start codons</a> or, for <a href="/wiki/Eukaryote" title="Eukaryote">eukaryotes</a>, <a href="/wiki/Genetic_code#Variations" title="Genetic code">mitochondrial genetic codes</a>.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> This alteration may, in some environments, help these <i>Candida</i> species by inducing a permanent stress response, a more generalized form of the <a href="/wiki/Heat_shock_response" title="Heat shock response">heat shock response</a>.<sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> However, this different codon usage makes it more difficult to study <i>C. albicans</i> protein-protein interactions in the model organism <i>S. cerevisiae</i>. To overcome this problem a <i>C. albicans</i> specific two-hybrid system was developed.<sup id="cite_ref-stynen_38-0" class="reference"><a href="#cite_note-stynen-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> </p><p>The genome of <i>C. albicans</i> is highly dynamic, contributed by the different CUG translation, and this variability has been used advantageously for molecular epidemiological studies and population studies in this species. The genome sequence has allowed for identifying the presence of a <a href="/wiki/Parasexual_cycle" title="Parasexual cycle">parasexual cycle</a> (no detected <a href="/wiki/Meiosis" title="Meiosis">meiotic division</a>) in <i>C. albicans</i>.<sup id="cite_ref-Butler_39-0" class="reference"><a href="#cite_note-Butler-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> This study of the evolution of sexual reproduction in six <i>Candida</i> species found recent losses in components of the major meiotic crossover-formation pathway, but retention of a minor pathway.<sup id="cite_ref-Butler_39-1" class="reference"><a href="#cite_note-Butler-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> The authors suggested that if <i>Candida</i> species undergo meiosis it is with reduced machinery, or different machinery, and indicated that unrecognized meiotic cycles may exist in many species. In another evolutionary study, introduction of partial CUG identity redefinition (from <i>Candida</i> species) into <i>Saccharomyces cerevisiae</i> clones caused a stress response that negatively affected sexual reproduction. This CUG identity redefinition, occurring in ancestors of <i>Candida</i> species, was thought to lock these species into a diploid or polyploid state with possible blockage of sexual reproduction.<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Morphology">Morphology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=3" title="Edit section: Morphology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>C. albicans</i> exhibits a wide range of <a href="/wiki/Morphology_(biology)" title="Morphology (biology)">morphological</a> <a href="/wiki/Phenotype" title="Phenotype">phenotypes</a> due to phenotypic switching and bud to hypha transition. The yeast-to-hyphae transition (filamentation) is a rapid process and induced by environmental factors. Phenotypic switching is spontaneous, happens at lower rates and in certain strains up to seven different phenotypes are known. The best studied switching mechanism is the white to opaque switching (an epigenetic process). Other systems have been described as well. Two systems (the high-frequency switching system and white to opaque switching) were discover by <a href="/wiki/David_R._Soll" title="David R. Soll">David R. Soll</a> and colleagues.<sup id="cite_ref-auto_41-0" class="reference"><a href="#cite_note-auto-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-High-frequency_switching_of_colony_42-0" class="reference"><a href="#cite_note-High-frequency_switching_of_colony-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> Switching in <i>C. albicans</i> is often, but not always, influenced by environmental conditions such as the level of CO<sub>2</sub>, anaerobic conditions, medium used and temperature.<sup id="cite_ref-High-frequency_switching_in_Candida_43-0" class="reference"><a href="#cite_note-High-frequency_switching_in_Candida-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> In its yeast form <i>C. albicans</i> ranges from 10 to 12 <a href="/wiki/Micrometre" title="Micrometre">microns</a>.<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> Spores can form on the pseudohyphae called <a href="/wiki/Chlamydospore" title="Chlamydospore">chlamydospores</a> which survive when put in unfavorable conditions such as dry or hot seasons.<sup id="cite_ref-microbewiki.kenyon.edu_45-0" class="reference"><a href="#cite_note-microbewiki.kenyon.edu-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Candida_albicans_mixed_colony.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7a/Candida_albicans_mixed_colony.jpg/220px-Candida_albicans_mixed_colony.jpg" decoding="async" width="220" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7a/Candida_albicans_mixed_colony.jpg/330px-Candida_albicans_mixed_colony.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7a/Candida_albicans_mixed_colony.jpg/440px-Candida_albicans_mixed_colony.jpg 2x" data-file-width="3085" data-file-height="2535" /></a><figcaption>An opaque colony of <i>C. albicans</i> growing as yeast-like cells with filamentous <i>C. albicans</i> cells on top</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Yeast-to-hypha_switching">Yeast-to-hypha switching</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=4" title="Edit section: Yeast-to-hypha switching"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Although often referred to as <b>dimorphic</b>, <i>C. albicans</i> is, in fact, <a href="/wiki/Polyphenism" title="Polyphenism">polyphenic</a> (often also referred to as <a href="/wiki/Pleomorphism_(microbiology)" title="Pleomorphism (microbiology)">pleomorphic</a>).<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> When cultured in standard yeast laboratory medium, <i>C. albicans</i> grows as ovoid "yeast" cells. However, mild environmental changes in temperature, CO<sub>2</sub>, nutrients and pH can result in a morphological shift to filamentous growth.<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> Filamentous cells share many similarities with yeast cells. Both cell types seem to play a specific, distinctive role in the survival and pathogenicity of <i>C. albicans</i>. Yeast cells seem to be better suited for the dissemination in the bloodstream while hyphal cells have been proposed as a virulence factor. Hyphal cells are invasive and speculated to be important for tissue penetration, colonization of organs and surviving plus escaping macrophages.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-51" class="reference"><a href="#cite_note-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> The transition from yeast to hyphal cells is termed to be one of the key factors in the virulence of <i>C. albicans</i>; however, it is not deemed necessary.<sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> When <i>C. albicans</i> cells are grown in a medium that mimics the physiological environment of a human host, they grow as filamentous cells (both true hyphae and pseudohyphae). <i>C. albicans</i> can also form <a href="/wiki/Chlamydospore" title="Chlamydospore">chlamydospores</a>, the function of which remains unknown, but it is speculated they play a role in surviving harsh environments as they are most often formed under unfavorable conditions.<sup id="cite_ref-Staib2007_53-0" class="reference"><a href="#cite_note-Staib2007-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup> </p><p>The cAMP-PKA signaling cascade is crucial for the morphogenesis and an important transcriptional regulator for the switch from yeast like cells to filamentous cells is EFG1.<sup id="cite_ref-54" class="reference"><a href="#cite_note-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Whiteopaquecandida.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Whiteopaquecandida.jpg/220px-Whiteopaquecandida.jpg" decoding="async" width="220" height="228" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Whiteopaquecandida.jpg/330px-Whiteopaquecandida.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Whiteopaquecandida.jpg/440px-Whiteopaquecandida.jpg 2x" data-file-width="673" data-file-height="696" /></a><figcaption>Round, white-phase and elongated, opaque-phase <i>Candida albicans</i> cells: the scale bar is 5 μm</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Whiteopaqueregulation.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Whiteopaqueregulation.jpg/220px-Whiteopaqueregulation.jpg" decoding="async" width="220" height="239" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Whiteopaqueregulation.jpg/330px-Whiteopaqueregulation.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1c/Whiteopaqueregulation.jpg/440px-Whiteopaqueregulation.jpg 2x" data-file-width="2150" data-file-height="2340" /></a><figcaption>In this model of the genetic network regulating the white-opaque switch, the white and gold boxes represent genes enriched in the white and opaque states, respectively. The blue lines represent relationships based on genetic epistasis. Red lines represent Wor1 control of each gene, based on Wor1 enrichment in chromatin immunoprecipitation experiments. Activation (arrowhead) and repression (bar) are inferred based on white- and opaque-state expression of each gene.</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="High-frequency_switching">High-frequency switching</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=5" title="Edit section: High-frequency switching"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Besides the well-studied yeast-to-hyphae transition other switching systems have been described.<sup id="cite_ref-56" class="reference"><a href="#cite_note-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup> One such system is the "high-frequency switching" system. During this switching different cellular morphologies (<a href="/wiki/Phenotype" title="Phenotype">phenotypes</a>) are generated spontaneously. This type of switching does not occur en masse, represents a variability system and it happens independently from environmental conditions.<sup id="cite_ref-High-frequency_switching_in_Candida_43-1" class="reference"><a href="#cite_note-High-frequency_switching_in_Candida-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> The strain 3153A produces at least seven different colony morphologies.<sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-High-frequency_switching_of_colony_42-1" class="reference"><a href="#cite_note-High-frequency_switching_of_colony-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup> In many strains the different phases convert spontaneously to the other(s) at a low frequency. The switching is reversible, and colony type can be inherited from one generation to another. Being able to switch through so many different (morphological) phenotypes makes <i>C. albicans</i> able to grow in different environments, both as a commensal and as a pathogen.<sup id="cite_ref-ReferenceC_59-0" class="reference"><a href="#cite_note-ReferenceC-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup> </p><p>In the 3153A strain, a gene called <a href="/wiki/Sirtuin_2" title="Sirtuin 2"><i>SIR2</i></a> (for silent information regulator), which seems to be important for phenotypic switching, has been found.<sup id="cite_ref-60" class="reference"><a href="#cite_note-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup> <i>SIR2</i> was originally found in <i><a href="/wiki/Saccharomyces_cerevisiae" title="Saccharomyces cerevisiae">Saccharomyces cerevisiae</a></i> (brewer's yeast), where it is involved in <a href="/wiki/Gene_silencing" title="Gene silencing">chromosomal silencing</a>—a form of <a href="/wiki/Transcriptional_regulation" title="Transcriptional regulation">transcriptional regulation</a>, in which regions of the <a href="/wiki/Genome" title="Genome">genome</a> are reversibly inactivated by changes in <a href="/wiki/Chromatin" title="Chromatin">chromatin</a> structure (chromatin is the complex of <a href="/wiki/DNA" title="DNA">DNA</a> and proteins that make <a href="/wiki/Chromosome" title="Chromosome">chromosomes</a>). In yeast, genes involved in the control of mating type are found in these silent regions, and <i>SIR2</i> represses their expression by maintaining a silent-competent chromatin structure in this region.<sup id="cite_ref-62" class="reference"><a href="#cite_note-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup> The discovery of a <i>C. albicans SIR2</i> implicated in phenotypic switching suggests it, too, has silent regions controlled by <i>SIR2</i>, in which the phenotype-specific genes may reside. How <i>SIR2</i> itself is regulated in <i>S. cerevisiae</i> may yet provide more clues as to the switching mechanisms of <i>C. albicans</i>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (August 2022)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="White-opaque_switching">White-opaque switching</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=6" title="Edit section: White-opaque switching"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Next to the <a href="/wiki/Sexual_dimorphism" title="Sexual dimorphism">dimorphism</a> and the first described high-frequency switching system <i>C. albicans</i> undergoes another high-frequency switching process called white-opaque switching, which is another <a href="/wiki/Phenotypic_switching" title="Phenotypic switching">phenotypic switching</a> process in <i>C. albicans</i>. It was the second high-frequency switching system discovered in <i>C. albicans</i>.<sup id="cite_ref-auto_41-1" class="reference"><a href="#cite_note-auto-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> The white-opaque switch is an <a href="/wiki/Epigenetics" title="Epigenetics">epigenetic</a> switching system.<sup id="cite_ref-ReferenceA_63-0" class="reference"><a href="#cite_note-ReferenceA-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup> Phenotypic switching is often used to refer to white-opaque switching, which consists of two phases: one that grows as round cells in smooth, white colonies (referred to as white form) and one that is rod-like and grows as flat, gray colonies (called opaque form). This switch between white cells and opaque cells is important for the virulence and the <a href="/wiki/Mating_of_yeast" title="Mating of yeast">mating</a> process of <i>C. albicans</i> as the opaque form is the <a href="/wiki/Mating_in_fungi" title="Mating in fungi">mating</a> competent form, being a million times more efficient in mating compared to the white type.<sup id="cite_ref-ReferenceA_63-1" class="reference"><a href="#cite_note-ReferenceA-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-64" class="reference"><a href="#cite_note-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-65" class="reference"><a href="#cite_note-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup> This switching between white and opaque form is regulated by the WOR1 regulator (White to Opaque Regulator 1) which is controlled by the <a href="/wiki/Mating_type" title="Mating type">mating type</a> locus (MTL) repressor (a1-α2) that inhibits the expression of WOR1.<sup id="cite_ref-66" class="reference"><a href="#cite_note-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup> Besides the white and opaque phase there is also a third one: the gray phenotype. This phenotype shows the highest ability to cause cutaneous infections. The white, opaque, and gray phenotypes form a phenotypic switching system where white cells switch to and from the opaque phase, white cells can irreversibly switch to the gray phase, and both white and gray cells can switch to and from the opaque/an opaque-like phase, respectively.<sup id="cite_ref-ReferenceC_59-1" class="reference"><a href="#cite_note-ReferenceC-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hemizygosity_enables_a_mutational_t_67-0" class="reference"><a href="#cite_note-Hemizygosity_enables_a_mutational_t-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup> Since it is often difficult to differentiate between white, opaque and gray cells phloxine B, a dye, can be added to the medium.<sup id="cite_ref-ReferenceC_59-2" class="reference"><a href="#cite_note-ReferenceC-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup> </p><p>A potential regulatory molecule in the white to opaque switching is <i>Efg1p</i>, a <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> found in the WO-1 strain that regulates dimorphism, and more recently has been suggested to help regulate phenotypic switching. <i>Efg1p</i> is expressed only in the white and not in the gray cell-type, and overexpression of <i>Efg1p</i> in the gray form causes a rapid conversion to the white form.<sup id="cite_ref-68" class="reference"><a href="#cite_note-68"><span class="cite-bracket">[</span>68<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-69" class="reference"><a href="#cite_note-69"><span class="cite-bracket">[</span>69<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hemizygosity_enables_a_mutational_t_67-1" class="reference"><a href="#cite_note-Hemizygosity_enables_a_mutational_t-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Environmental_stress">Environmental stress</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=7" title="Edit section: Environmental stress"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Glucose starvation is a likely common environmental stress encountered by <i>C. albicans</i> in its natural habitat.<sup id="cite_ref-Guan2019_70-0" class="reference"><a href="#cite_note-Guan2019-70"><span class="cite-bracket">[</span>70<span class="cite-bracket">]</span></a></sup> Glucose starvation causes an increase in <a href="/wiki/Reactive_oxygen_species" title="Reactive oxygen species">intracellular reactive oxygen</a>. This stress can lead to mating between two individuals of the same mating type, an interaction that may be frequent in nature under stressful conditions.<sup id="cite_ref-Guan2019_70-1" class="reference"><a href="#cite_note-Guan2019-70"><span class="cite-bracket">[</span>70<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="White-GUT_switch">White-GUT switch</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=8" title="Edit section: White-GUT switch"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A very special type of phenotypic switch is the white-GUT switch (Gastrointestinally-IndUced Transition). GUT cells are extremely adapted to survival in the digestive tract by metabolic adaptations to available nutrients in the digestive tract. The GUT cells live as commensal organisms and outcompete other phenotypes. The transition from white to GUT cells is driven by passage through the gut where environmental parameters trigger this transition by increasing the WOR1 expression.<sup id="cite_ref-71" class="reference"><a href="#cite_note-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-72" class="reference"><a href="#cite_note-72"><span class="cite-bracket">[</span>72<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_disease">Role in disease</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=9" title="Edit section: Role in disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Candidiasis" title="Candidiasis">Candidiasis</a></div> <p><i>Candida</i> is found worldwide but most commonly compromises immunocompromised individuals diagnosed with serious diseases such as HIV and cancer. <i>Candida</i> are ranked as one of the most common groups of organisms that cause <a href="/wiki/Hospital-acquired_infection" title="Hospital-acquired infection">hospital-acquired infections</a>. Especially high-risk individuals are patients that have recently undergone surgery, a transplant or are in the Intensive Care Units (ICU),<sup id="cite_ref-:0_73-0" class="reference"><a href="#cite_note-:0-73"><span class="cite-bracket">[</span>73<span class="cite-bracket">]</span></a></sup> <i>C. albicans</i> infections is the top source of fungal infections in critically ill or otherwise immunocompromised patients.<sup id="cite_ref-74" class="reference"><a href="#cite_note-74"><span class="cite-bracket">[</span>74<span class="cite-bracket">]</span></a></sup> These patients predominantly develop oropharyngeal or thrush candidiasis, which can lead to malnutrition and interfere with the absorption of medication.<sup id="cite_ref-75" class="reference"><a href="#cite_note-75"><span class="cite-bracket">[</span>75<span class="cite-bracket">]</span></a></sup> Methods of transmission include mother to infant through childbirth, people-to-people acquired infections that most commonly occur in hospital settings where immunocompromised patients acquire the yeast from healthcare workers and has a 40% incident rate.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (November 2020)">citation needed</span></a></i>]</sup> People can become infected after having sex with a woman that has an existing vaginal yeast infection.<sup id="cite_ref-:0_73-1" class="reference"><a href="#cite_note-:0-73"><span class="cite-bracket">[</span>73<span class="cite-bracket">]</span></a></sup> Parts of the body that are commonly infected include the skin, genitals, throat, mouth, and blood.<sup id="cite_ref-76" class="reference"><a href="#cite_note-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup> Distinguishing features of vaginal infection include discharge, and dry and red appearance of vaginal mucosa or skin. <i>Candida</i> continues to be the fourth most commonly isolated organism in bloodstream infections.<sup id="cite_ref-77" class="reference"><a href="#cite_note-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup> Healthy people usually do not suffer (severely) from superficial infections caused by a local alteration in cellular immunity as seen by asthma patients that use oral corticosteroids.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (January 2021)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Superficial_and_local_infections">Superficial and local infections</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=10" title="Edit section: Superficial and local infections"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It commonly occurs as a <a href="/wiki/Mycosis" class="mw-redirect" title="Mycosis">superficial infection</a> on mucous membranes in the <a href="/wiki/Oral_candidiasis" title="Oral candidiasis">mouth</a> or vagina. Once in their lives around 75% of women will suffer from <a href="/wiki/Vaginal_yeast_infection" title="Vaginal yeast infection">vulvovaginal candidiasis (VVC)</a> and about 90% of these infections are caused by <i>C. albicans</i>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (February 2021)">citation needed</span></a></i>]</sup> It may also affect a <a href="/wiki/Candidiasis#Classification" title="Candidiasis">number of other regions</a>. For example, higher <a href="/wiki/Prevalence" title="Prevalence">prevalence</a> of <a href="/wiki/Colonisation_(biology)" title="Colonisation (biology)">colonization</a> of <i>C. albicans</i> was reported in young individuals with <a href="/wiki/Tongue_piercing" title="Tongue piercing">tongue piercing</a>, in comparison to unpierced matched individuals,<sup id="cite_ref-Candida_78-0" class="reference"><a href="#cite_note-Candida-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup> but not in healthy young individuals who use intraoral orthodontic acrylic appliances.<sup id="cite_ref-ORTHO_79-0" class="reference"><a href="#cite_note-ORTHO-79"><span class="cite-bracket">[</span>79<span class="cite-bracket">]</span></a></sup> To infect host tissue, the usual <a href="/wiki/Unicellular_organism" title="Unicellular organism">unicellular</a> yeast-like form of <i>C. albicans</i> reacts to environmental cues and switches into an invasive, multicellular filamentous form, a phenomenon called <a href="/wiki/Dimorphic_fungus" title="Dimorphic fungus">dimorphism</a>.<sup id="cite_ref-Sherris_80-0" class="reference"><a href="#cite_note-Sherris-80"><span class="cite-bracket">[</span>80<span class="cite-bracket">]</span></a></sup> In addition, an overgrowth infection is considered a superinfection, the term usually applied when an infection becomes opportunistic and very <a href="/wiki/Antimicrobial_resistance" title="Antimicrobial resistance">resistant</a> to <a href="/wiki/Antifungal" title="Antifungal">antifungals</a>. It then becomes suppressible by antibiotics<sup class="noprint Inline-Template" style="margin-left:0.1em; white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Please_clarify" title="Wikipedia:Please clarify"><span title="please clarify antifungal vs antibiotic vs antibacterial, and "then becomes suppressible" vs need another method of treatment (July 2020)">clarification needed</span></a></i>]</sup><sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="this info not present in the existing citations (July 2020)">citation needed</span></a></i>]</sup>. The infection is prolonged when the original sensitive strain is replaced by the antifungal-resistant strain.<sup id="cite_ref-81" class="reference"><a href="#cite_note-81"><span class="cite-bracket">[</span>81<span class="cite-bracket">]</span></a></sup> </p><p>Candidiasis is known to cause gastrointestinal (GI) symptoms particularly in immunocompromised patients or those receiving steroids (e.g. to treat <a href="/wiki/Asthma" title="Asthma">asthma</a>) or antibiotics. Recently, there is an emerging literature that an overgrowth of fungus in the small intestine of non-immunocompromised subjects may cause unexplained GI symptoms. Small intestinal fungal overgrowth (SIFO) is characterized by the presence of an excessive number of fungal organisms in the small intestine associated with gastrointestinal symptoms. The most common symptoms observed in these patients were belching, bloating, indigestion, nausea, diarrhea, and gas. The underlying mechanism(s) that predisposes to SIFO is unclear. Further studies are needed; both to confirm these observations and to examine the clinical relevance of fungal overgrowth.<sup id="cite_ref-SIFO_9-3" class="reference"><a href="#cite_note-SIFO-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24789109_10-3" class="reference"><a href="#cite_note-pmid24789109-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid25385227_82-0" class="reference"><a href="#cite_note-pmid25385227-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Systemic_infections">Systemic infections</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=11" title="Edit section: Systemic infections"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Systemic fungal infections (<a href="/wiki/Fungemia" title="Fungemia">fungemias</a>) including those by <i>C. albicans</i> have emerged as important causes of <a href="/wiki/Morbidity" class="mw-redirect" title="Morbidity">morbidity</a> and <a href="/wiki/Death" title="Death">mortality</a> in <a href="/wiki/Immunodeficiency" title="Immunodeficiency">immunocompromised</a> patients (e.g., <a href="/wiki/HIV/AIDS" title="HIV/AIDS">AIDS</a>, cancer <a href="/wiki/Chemotherapy" title="Chemotherapy">chemotherapy</a>, organ or <a href="/wiki/Bone_marrow" title="Bone marrow">bone marrow</a> transplantation). <i>C. albicans</i> often forms biofilms inside the body. Such <i>C. albicans</i> <a href="/wiki/Biofilm" title="Biofilm">biofilms</a> may form on the surface of implantable medical devices or organs. In these biofilms it is often found together with <i><a href="/wiki/Staphylococcus_aureus" title="Staphylococcus aureus">Staphylococcus aureus</a></i>.<sup id="cite_ref-Kumamoto2002_12-1" class="reference"><a href="#cite_note-Kumamoto2002-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Donlan2001_13-1" class="reference"><a href="#cite_note-Donlan2001-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-83" class="reference"><a href="#cite_note-83"><span class="cite-bracket">[</span>83<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-84" class="reference"><a href="#cite_note-84"><span class="cite-bracket">[</span>84<span class="cite-bracket">]</span></a></sup> Such multispecies infections lead to higher mortalities.<sup id="cite_ref-85" class="reference"><a href="#cite_note-85"><span class="cite-bracket">[</span>85<span class="cite-bracket">]</span></a></sup> In addition <a href="/wiki/Nosocomial_infection" class="mw-redirect" title="Nosocomial infection">hospital-acquired infections</a> by <i>C. albicans</i> have become a cause of major health concerns.<sup id="cite_ref-Calderone_11-2" class="reference"><a href="#cite_note-Calderone-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-86" class="reference"><a href="#cite_note-86"><span class="cite-bracket">[</span>86<span class="cite-bracket">]</span></a></sup> Especially once candida cells are introduced in the bloodstream a high mortality, up to 40–60% can occur.<sup id="cite_ref-Calderone_11-3" class="reference"><a href="#cite_note-Calderone-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-87" class="reference"><a href="#cite_note-87"><span class="cite-bracket">[</span>87<span class="cite-bracket">]</span></a></sup> </p><p>Although <i>Candida albicans</i> is the most common cause of <a href="/wiki/Fungemia" title="Fungemia">candidemia</a>, there has been a decrease in the incidence and an increased isolation of non-albicans species of <i>Candida</i> in recent years.<sup id="cite_ref-88" class="reference"><a href="#cite_note-88"><span class="cite-bracket">[</span>88<span class="cite-bracket">]</span></a></sup> Preventive measures include maintaining a good oral hygiene, keeping a healthy lifestyle including good nutrition, the careful use of antibiotics, treatment of infected areas and keeping skin dry and clean, free from open wounds.<sup id="cite_ref-89" class="reference"><a href="#cite_note-89"><span class="cite-bracket">[</span>89<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-90" class="reference"><a href="#cite_note-90"><span class="cite-bracket">[</span>90<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Role_of_C._albicans_in_Crohn's_disease"><span id="Role_of_C._albicans_in_Crohn.27s_disease"></span>Role of <i>C. albicans</i> in Crohn's disease</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=12" title="Edit section: Role of C. albicans in Crohn's disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The link between <i>C. albicans</i> and Crohn's disease has been investigated in a large cohort. This study demonstrated that members of families with multiple cases of Crohn's disease were more likely to be colonized by <i>C. albicans</i> than members of control families.<sup id="cite_ref-91" class="reference"><a href="#cite_note-91"><span class="cite-bracket">[</span>91<span class="cite-bracket">]</span></a></sup> Experimental studies show that chemically induced colitis promotes <i>C. albicans</i> colonization. In turn, <i>C. albicans</i> colonization generates anti-<i>Saccharomyces cerevisiae</i> antibodies (ASCA), increases inflammation, histological scores and pro-inflammatory cytokine expression.<sup id="cite_ref-92" class="reference"><a href="#cite_note-92"><span class="cite-bracket">[</span>92<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-93" class="reference"><a href="#cite_note-93"><span class="cite-bracket">[</span>93<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Diagnosis">Diagnosis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=13" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A United States study in 2022 showed that most cases of candidiasis are treated <a href="/wiki/Empiric_therapy" title="Empiric therapy">empirically</a> (without culture, pending culture or by symptoms in cases where culture did not show candida), thus not knowing whether the subtype is <i>Candida albicans</i> or any other candida species.<sup id="cite_ref-pmid36505943_94-0" class="reference"><a href="#cite_note-pmid36505943-94"><span class="cite-bracket">[</span>94<span class="cite-bracket">]</span></a></sup> For subtyping of candidiasis, a <a href="/w/index.php?title=Fungal_culture&action=edit&redlink=1" class="new" title="Fungal culture (page does not exist)">fungal culture</a> can be performed, followed by a <a href="/wiki/Germ_tube" title="Germ tube">germ tube</a> test in which a sample of fungal spores are suspended in animal <a href="/wiki/Blood_serum" class="mw-redirect" title="Blood serum">serum</a> and examined by <a href="/wiki/Microscopy" title="Microscopy">microscopy</a> for the detection of any germ tubes.<sup id="cite_ref-doctorfungus_95-0" class="reference"><a href="#cite_note-doctorfungus-95"><span class="cite-bracket">[</span>95<span class="cite-bracket">]</span></a></sup> Colonies of white or cream color on fungal culture having a positive germ tube test is strongly indicative of <i>Candida albicans</i>.<sup id="cite_ref-doctorfungus_95-1" class="reference"><a href="#cite_note-doctorfungus-95"><span class="cite-bracket">[</span>95<span class="cite-bracket">]</span></a></sup> </p> <ul class="gallery mw-gallery-traditional"> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Candida_albicans_PHIL_3192_lores.jpg" class="mw-file-description" title="Agar plate culture of C. albicans"><img alt="Agar plate culture of C. albicans" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Candida_albicans_PHIL_3192_lores.jpg/120px-Candida_albicans_PHIL_3192_lores.jpg" decoding="async" width="120" height="80" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Candida_albicans_PHIL_3192_lores.jpg/180px-Candida_albicans_PHIL_3192_lores.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Candida_albicans_PHIL_3192_lores.jpg/240px-Candida_albicans_PHIL_3192_lores.jpg 2x" data-file-width="3072" data-file-height="2048" /></a></span></div> <div class="gallerytext"><a href="/wiki/Agar_plate" title="Agar plate">Agar plate</a> culture of <i>C. albicans</i></div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:C_albicans_germ_tubes.jpg" class="mw-file-description" title="Germ tubes of Candida albicans"><img alt="Germ tubes of Candida albicans" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/12/C_albicans_germ_tubes.jpg/120px-C_albicans_germ_tubes.jpg" decoding="async" width="120" height="90" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/12/C_albicans_germ_tubes.jpg/180px-C_albicans_germ_tubes.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/1/12/C_albicans_germ_tubes.jpg 2x" data-file-width="240" data-file-height="180" /></a></span></div> <div class="gallerytext">Germ tubes of <i>Candida albicans</i></div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Candida_Gram_stain.jpg" class="mw-file-description" title="Gram stain of Candida albicans from a vaginal swab; the small oval chlamydospores are 2–4 μm in diameter"><img alt="Gram stain of Candida albicans from a vaginal swab; the small oval chlamydospores are 2–4 μm in diameter" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Candida_Gram_stain.jpg/120px-Candida_Gram_stain.jpg" decoding="async" width="120" height="80" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Candida_Gram_stain.jpg/180px-Candida_Gram_stain.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Candida_Gram_stain.jpg/240px-Candida_Gram_stain.jpg 2x" data-file-width="6000" data-file-height="4000" /></a></span></div> <div class="gallerytext"><a href="/wiki/Gram_stain" title="Gram stain">Gram stain</a> of <i>Candida albicans</i> from a vaginal swab; the small oval <a href="/wiki/Chlamydospore" title="Chlamydospore">chlamydospores</a> are 2–4 <a href="/wiki/Micrometre" title="Micrometre">μm</a> in diameter </div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:CHROMAgar_with_N_glabratus,_P_kudriavzevii,_Candida_albicans_and_Candida_tropicalis,_annotated.jpg" class="mw-file-description" title="Chromogenic agar can help in indicating main species of Candida versus similar fungi. (CHROMAgar shown)"><img alt="Chromogenic agar can help in indicating main species of Candida versus similar fungi. (CHROMAgar shown)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/05/CHROMAgar_with_N_glabratus%2C_P_kudriavzevii%2C_Candida_albicans_and_Candida_tropicalis%2C_annotated.jpg/120px-CHROMAgar_with_N_glabratus%2C_P_kudriavzevii%2C_Candida_albicans_and_Candida_tropicalis%2C_annotated.jpg" decoding="async" width="120" height="85" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/05/CHROMAgar_with_N_glabratus%2C_P_kudriavzevii%2C_Candida_albicans_and_Candida_tropicalis%2C_annotated.jpg/180px-CHROMAgar_with_N_glabratus%2C_P_kudriavzevii%2C_Candida_albicans_and_Candida_tropicalis%2C_annotated.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/05/CHROMAgar_with_N_glabratus%2C_P_kudriavzevii%2C_Candida_albicans_and_Candida_tropicalis%2C_annotated.jpg/240px-CHROMAgar_with_N_glabratus%2C_P_kudriavzevii%2C_Candida_albicans_and_Candida_tropicalis%2C_annotated.jpg 2x" data-file-width="4481" data-file-height="3161" /></a></span></div> <div class="gallerytext">Chromogenic agar can help in indicating main species of <i>Candida</i> versus similar fungi. (CHROMAgar shown)</div> </li> <li class="gallerybox" style="width: 155px"> <div class="thumb" style="width: 150px; height: 150px;"><span typeof="mw:File"><a href="/wiki/File:Mycology_algorithm.png" class="mw-file-description" title="Algorithm for the diagnosis of Candida albicans versus differential diagnoses"><img alt="Algorithm for the diagnosis of Candida albicans versus differential diagnoses" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Mycology_algorithm.png/120px-Mycology_algorithm.png" decoding="async" width="120" height="103" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Mycology_algorithm.png/180px-Mycology_algorithm.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Mycology_algorithm.png/240px-Mycology_algorithm.png 2x" data-file-width="2889" data-file-height="2477" /></a></span></div> <div class="gallerytext">Algorithm for the diagnosis of <i>Candida albicans</i> versus differential diagnoses</div> </li> </ul> <div class="mw-heading mw-heading3"><h3 id="Treatment">Treatment</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=14" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There are relatively few drugs that can successfully treat Candidiasis.<sup id="cite_ref-Sellama_96-0" class="reference"><a href="#cite_note-Sellama-96"><span class="cite-bracket">[</span>96<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-97" class="reference"><a href="#cite_note-97"><span class="cite-bracket">[</span>97<span class="cite-bracket">]</span></a></sup> Treatment commonly includes:<sup id="cite_ref-98" class="reference"><a href="#cite_note-98"><span class="cite-bracket">[</span>98<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Amphotericin_B" title="Amphotericin B">amphotericin B</a>, <a href="/wiki/Echinocandin" title="Echinocandin">echinocandin</a>, or <a href="/wiki/Fluconazole" title="Fluconazole">fluconazole</a> for systemic infections</li> <li><a href="/wiki/Nystatin" title="Nystatin">nystatin</a> for oral and esophageal infections</li> <li><a href="/wiki/Clotrimazole" title="Clotrimazole">clotrimazole</a> for skin and genital yeast infections<sup id="cite_ref-99" class="reference"><a href="#cite_note-99"><span class="cite-bracket">[</span>99<span class="cite-bracket">]</span></a></sup></li></ul> <p>Similarly to antibiotic resistance, resistance to many anti-fungals is becoming a problem. New anti-fungals have to be developed to cope with this problem since only a limited number of anti-fungals are available.<sup id="cite_ref-Sellama_96-1" class="reference"><a href="#cite_note-Sellama-96"><span class="cite-bracket">[</span>96<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-100" class="reference"><a href="#cite_note-100"><span class="cite-bracket">[</span>100<span class="cite-bracket">]</span></a></sup> A general problem is that in contrast to bacteria, fungi are often overlooked as a potential health problem.<sup id="cite_ref-101" class="reference"><a href="#cite_note-101"><span class="cite-bracket">[</span>101<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Economic_implications">Economic implications</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=15" title="Edit section: Economic implications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Given the fact that candidiasis is the fourth- (to third-) most frequent hospital acquired infection worldwide it leads to immense financial implications. Approximately 60,000 cases of systemic candidiasis each year in the USA alone lead up to a cost to be between $2–4 billion.<sup id="cite_ref-102" class="reference"><a href="#cite_note-102"><span class="cite-bracket">[</span>102<span class="cite-bracket">]</span></a></sup> The total costs for candidiasis are among the highest compared to other fungal infections due to the high prevalence.<sup id="cite_ref-103" class="reference"><a href="#cite_note-103"><span class="cite-bracket">[</span>103<span class="cite-bracket">]</span></a></sup> The immense costs are partly explained by a longer stay in the intensive care unit or hospital in general. An extended stay for up to 21 more days compared to non-infected patients is not uncommon.<sup id="cite_ref-104" class="reference"><a href="#cite_note-104"><span class="cite-bracket">[</span>104<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Role_of_GSDMD_in_C.albicans_infection">Role of GSDMD in C.albicans infection</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=16" title="Edit section: Role of GSDMD in C.albicans infection"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Gasdermin D (GSDMD) is a protein that in humans is encoded by the GSDMD gene and is a known target of the inflammasome and acts as an effector molecule of programmed cell death known as pyroptosis. This protein determines cell lysis to prevent pathogen replication and results in the release of the inflammatory cytokine interleukin-1β (IL-1β) into the extracellular space to recruit and activate immune cells at the site of infection. Inflammasome activation due to C.albicans infection triggers the release of a <a href="/wiki/Cytokine_storm" title="Cytokine storm">cytokine storm</a> necessary to fight the pathogen. Excessive release of these pro-inflammatory mediators has been shown to exaggerate systemic inflammation leading to vascular injury and damage to vital organs. Unfortunately, Candida albicans therapy is often ineffective despite the availability of many antifungal drugs, mainly because of resistance phenomena. During conventional pyroptosis controlled by the inflammasome-GSDMD axis is hijacked by C. albicans to facilitate escape from macrophages through unfolding of hyphae and candidalysin, a fungal toxin released from hyphae. It has been shown<sup id="cite_ref-105" class="reference"><a href="#cite_note-105"><span class="cite-bracket">[</span>105<span class="cite-bracket">]</span></a></sup> that disruption of GSDMD in macrophages infected with Candida albicans reduces the fungal load. In addition, the presence of hyphae and candidalysin are key factors in the activation of GSDMD and the release of Candida from macrophages. Also using Candida-infected mice, inhibition of GSDMD has been shown to paradoxically improve prognosis and survival, indicating that this protein may be a potential therapeutic target in C. albicans-induced sepsis.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (March 2023)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biofilm_development">Biofilm development</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=17" title="Edit section: Biofilm development"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Biofilm_formation_steps">Biofilm formation steps</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=18" title="Edit section: Biofilm formation steps"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The biofilm of <i>C. albicans</i> is formed in four steps. First, there is the initial adherence step, where the yeast-form cells adhere to the substrate. The second step is called Intermediate step, where the cells propagate to form <a href="/wiki/Microcolony" title="Microcolony">microcolonies</a>, and germ tubes form to yield hyphae. In the maturation step, the biofilm biomass expands, the extracellular matrix accumulates and drug resistance increases. In the last step of biofilm formation, the yeast-form cells are released to colonize the surrounding environment (dispersion). Yeast cells released from a biofilm have novel properties, including increased virulence and drug tolerance.<sup id="cite_ref-106" class="reference"><a href="#cite_note-106"><span class="cite-bracket">[</span>106<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-107" class="reference"><a href="#cite_note-107"><span class="cite-bracket">[</span>107<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-108" class="reference"><a href="#cite_note-108"><span class="cite-bracket">[</span>108<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Zap1">Zap1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=19" title="Edit section: Zap1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Zap1, also known as Csr1 and Sur1 (zinc-responsive activator protein), is a transcription factor required for the <i>C. albicans</i> hypha formation in biofilms. Zap1 controls the equilibrium of yeast and hyphal cells, the zinc transporters and zinc regulated genes in biofilms of <i>C. albicans</i>.<sup id="cite_ref-109" class="reference"><a href="#cite_note-109"><span class="cite-bracket">[</span>109<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Zinc">Zinc</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=20" title="Edit section: Zinc"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Zinc (Zn<sup>2+</sup>) is important for cell function of <i>C. albicans</i> and Zap1 controls the Zinc levels in the cells through the zinc transporters Zrt1 and Zrt2. The regulation of zinc concentration in the cells is important for the cell viability and if the zinc levels get too high, it is toxic for the cells. The Zrt1 is transporting the zinc ions with high affinity and the Zrt2 is transporting the zinc ions with low affinity.<sup id="cite_ref-110" class="reference"><a href="#cite_note-110"><span class="cite-bracket">[</span>110<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mechanisms_and_proteins_important_for_pathogenesis">Mechanisms and proteins important for pathogenesis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=21" title="Edit section: Mechanisms and proteins important for pathogenesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Filamentation">Filamentation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=22" title="Edit section: Filamentation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The ability to switch between yeast cells and hyphal cells is an important virulence factor. Many proteins play a role in this very complex process.<sup id="cite_ref-111" class="reference"><a href="#cite_note-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup> The formation of hyphae can for example help <i>Candida albicans</i> to escape from macrophages in the human body.<sup id="cite_ref-112" class="reference"><a href="#cite_note-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup> Moreover, <i>C. albicans</i> undergo yeast-to-hyphal transition within the acidic macrophage phagosome. This initially causes phagosome membrane distension which eventually leads to phagosomal alkalinization by physical rupture, followed by escape.<sup id="cite_ref-113" class="reference"><a href="#cite_note-113"><span class="cite-bracket">[</span>113<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Hwp1">Hwp1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=23" title="Edit section: Hwp1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Hwp1" title="Hwp1">Hwp1</a></div> <p>Hwp1 stands for Hyphal wall protein 1. Hwp1 is a mannoprotein located on the surface of the hyphae in the hyphal form of <i>C. albicans</i>. Hwp1 is a mammalian <a href="/wiki/Transglutaminase" title="Transglutaminase">transglutaminase</a> substrate. This host enzyme allows <i>Candida albicans</i> to <a href="/wiki/Fungal_adhesin" title="Fungal adhesin">attach</a> stably to host epithelial cells.<sup id="cite_ref-Staab1999_114-0" class="reference"><a href="#cite_note-Staab1999-114"><span class="cite-bracket">[</span>114<span class="cite-bracket">]</span></a></sup> Adhesion of <i>C. albicans</i> to host cells is an essential first step in the infection process for colonization and subsequent induction of mucosal infection.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (January 2021)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Slr1">Slr1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=24" title="Edit section: Slr1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/RNA-binding_protein" title="RNA-binding protein">RNA-binding protein</a> Slr1 plays a role in instigating hyphal formation and virulence in <i>C. albicans</i>.<sup id="cite_ref-AriyachetSolis2013_115-0" class="reference"><a href="#cite_note-AriyachetSolis2013-115"><span class="cite-bracket">[</span>115<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Candidalysin">Candidalysin</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=25" title="Edit section: Candidalysin"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Candidalysin" title="Candidalysin">Candidalysin</a> is a cytolytic 31-amino acid α-helical peptide toxin that is released by <i>C. albicans</i> during hyphal formation. It contributes to virulence during mucosal infections.<sup id="cite_ref-116" class="reference"><a href="#cite_note-116"><span class="cite-bracket">[</span>116<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="PRA1">PRA1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=26" title="Edit section: PRA1"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>During vaginal infections PRA1 (pH-regulated antigen) gene is up-regulated. Its expression correlates with the concentration of <a href="/wiki/Proinflammatory_cytokines" class="mw-redirect" title="Proinflammatory cytokines">proinflammatory cytokines</a>.<sup id="cite_ref-rose_117-0" class="reference"><a href="#cite_note-rose-117"><span class="cite-bracket">[</span>117<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Genetic_and_genomic_tools">Genetic and genomic tools</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=27" title="Edit section: Genetic and genomic tools"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Due to its nature as a model organism, being an important human pathogen and the alternative codon usage (CUG translated into serine rather than leucine), several specific projects and tools have been created to study <i>C. albicans</i>.<sup id="cite_ref-Calderone_11-4" class="reference"><a href="#cite_note-Calderone-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The diploid nature and the absence of a sexual cycle make the organism difficult to study, but in the last 20 years, many systems have been developed to observe its genetics.<sup id="cite_ref-Kabir_19-1" class="reference"><a href="#cite_note-Kabir-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Selection_markers">Selection markers</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=28" title="Edit section: Selection markers"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The selection markers most used in <i>C. albicans</i> are the CaNAT1 resistance marker (confers resistance against <a href="/wiki/Nourseothricin" title="Nourseothricin">nourseothricin</a>) and MPAr or IMH3r (confers resistance to <a href="/wiki/Mycophenolic_acid" title="Mycophenolic acid">mycophenolic acid</a>).<sup id="cite_ref-118" class="reference"><a href="#cite_note-118"><span class="cite-bracket">[</span>118<span class="cite-bracket">]</span></a></sup> Next to the above-mentioned selection makers a few auxotrophic strains were generated to work with auxotrophic makers. The <a href="/wiki/URA3" title="URA3">URA3</a> marker (URA3 blaster method) is an often-used strategy in uridine auxotrophic strains; however, studies have shown that differences in URA3 position in the genome can be involved in the pathogeny of <i>C. albicans</i>.<sup id="cite_ref-119" class="reference"><a href="#cite_note-119"><span class="cite-bracket">[</span>119<span class="cite-bracket">]</span></a></sup> Besides the URA3 selection one can also use the histidine, leucine and arginine autotrophy. The advantage of using those autotrophies lies in the fact that they exhibit wild-type or nearly wild-type virulence in a mouse model compared to the URA3 system.<sup id="cite_ref-120" class="reference"><a href="#cite_note-120"><span class="cite-bracket">[</span>120<span class="cite-bracket">]</span></a></sup> One application of the leucine, arginine and histidine autotrophy is for example the candida two-hybrid system.<sup id="cite_ref-stynen_38-1" class="reference"><a href="#cite_note-stynen-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Full_sequence_genome">Full sequence genome</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=29" title="Edit section: Full sequence genome"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The full genome of <i>C. albicans</i> has been sequenced and made publicly available in a <a rel="nofollow" class="external text" href="http://www.candidagenome.org">Candida database</a>. The heterozygous diploid strain used for this full genome sequence project is the laboratory strain SC5314. The sequencing was done using a whole-genome shotgun approach.<sup id="cite_ref-121" class="reference"><a href="#cite_note-121"><span class="cite-bracket">[</span>121<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="ORFeome_project">ORFeome project</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=30" title="Edit section: ORFeome project"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Every predicted ORF has been created in a gateway adapted vector (pDONR207) and made publicly available. The vectors (<a href="/wiki/Plasmid" title="Plasmid">plasmids</a>) can be propagated in <i>E.coli</i> and grown on LB+<a href="/wiki/Gentamicin" title="Gentamicin">gentamicin</a> medium. This way every ORF is readily available in an easy to use vector. Using the gateway system it is possible to transfer the ORF of interest to any other gateway adapted vector for further studies of the specific ORF.<sup id="cite_ref-ReferenceB_29-1" class="reference"><a href="#cite_note-ReferenceB-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-122" class="reference"><a href="#cite_note-122"><span class="cite-bracket">[</span>122<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="CIp10_integrative_plasmid">CIp10 integrative plasmid</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=31" title="Edit section: CIp10 integrative plasmid"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Contrary to the yeast <a href="/wiki/Saccharomyces_cerevisiae" title="Saccharomyces cerevisiae"><i>S. cerevisiae</i></a> episomal plasmids do not stay stable in <i>C. albicans</i>. In order to work with plasmids in <i>C. albicans</i> an integrative approach (plasmid integration into the genome) thus has to be used. A second problem is that most plasmid transformations are rather inefficient in <i>C. albicans</i>; however, the CIp10 plasmid overcomes these problems and can be used with ease to transform <i>C. albicans</i> in a very efficient way. The plasmid integrates inside the RP10 locus as disruption of one RP10 allele does not seem to affect the viability and growth of <i>C. albicans</i>. Several adaptations of this plasmid have been made after the original became available.<sup id="cite_ref-123" class="reference"><a href="#cite_note-123"><span class="cite-bracket">[</span>123<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-auto2_124-0" class="reference"><a href="#cite_note-auto2-124"><span class="cite-bracket">[</span>124<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Candida_two-hybrid_(C2H)_system"><span id="Candida_two-hybrid_.28C2H.29_system"></span>Candida two-hybrid (C2H) system</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=32" title="Edit section: Candida two-hybrid (C2H) system"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Due to the aberrant codon usage of <i>C. albicans</i> it is less feasible to use the common host organism (<i><a href="/wiki/Saccharomyces_cerevisiae" title="Saccharomyces cerevisiae">Saccharomyces cerevisiae</a></i>) for <a href="/wiki/Two-hybrid_screening" title="Two-hybrid screening">two-hybrid studies</a>. To overcome this problem a <i>C. albicans</i> two-hybrid (C2H) system was created. The strain SN152 that is auxotrophic for leucine, arginine and histidine was used to create this C2H system. It was adapted by integrating a HIS1 reporter gene preceded by five LexAOp sequences. In the C2H system the bait plasmid (pC2HB) contains the <i><a href="/wiki/Staphylococcus_aureus" title="Staphylococcus aureus">Staphylococcus aureus</a></i> LexA BD, while the prey plasmid (pC2HP) harbors the viral AD VP16. Both plasmids are integrative plasmids since episomal plasmids do not stay stable in <i>C. albicans</i>. The reporter gene used in the system is the <i>HIS1</i> gene. When proteins interact, the cells will be able to grow on medium lacking histidine due to the activation of the <i>HIS1</i> reporter gene.<sup id="cite_ref-Calderone_11-5" class="reference"><a href="#cite_note-Calderone-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-stynen_38-2" class="reference"><a href="#cite_note-stynen-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> Several interactions have thus far been detected using this system in a low scale set up.<sup id="cite_ref-stynen_38-3" class="reference"><a href="#cite_note-stynen-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-125" class="reference"><a href="#cite_note-125"><span class="cite-bracket">[</span>125<span class="cite-bracket">]</span></a></sup> A first high-throughput screening has also been performed.<sup id="cite_ref-126" class="reference"><a href="#cite_note-126"><span class="cite-bracket">[</span>126<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-frontiersin.org_127-0" class="reference"><a href="#cite_note-frontiersin.org-127"><span class="cite-bracket">[</span>127<span class="cite-bracket">]</span></a></sup> Interacting proteins can be found at the <a href="/wiki/BioGRID" title="BioGRID">BioGRID</a>.<sup id="cite_ref-128" class="reference"><a href="#cite_note-128"><span class="cite-bracket">[</span>128<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Bimolecular_fluorescence_complementation_(BiFC)"><span id="Bimolecular_fluorescence_complementation_.28BiFC.29"></span>Bimolecular fluorescence complementation (BiFC)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=33" title="Edit section: Bimolecular fluorescence complementation (BiFC)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Besides the C2H system, a <a href="/wiki/Bimolecular_fluorescence_complementation" title="Bimolecular fluorescence complementation">BiFC</a> system has been developed to study protein-protein interactions in <i>C. albicans</i>. With this systems protein interactions can be studied in their native sub cellular location contrary to a C2H system in which the proteins are forced into the nucleus. With BiFC one can study for example protein interactions that take place at the cell membrane or vacuolar membrane.<sup id="cite_ref-frontiersin.org_127-1" class="reference"><a href="#cite_note-frontiersin.org-127"><span class="cite-bracket">[</span>127<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-129" class="reference"><a href="#cite_note-129"><span class="cite-bracket">[</span>129<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-130" class="reference"><a href="#cite_note-130"><span class="cite-bracket">[</span>130<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Microarrays">Microarrays</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=34" title="Edit section: Microarrays"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Both DNA and protein microarrays were designed to study DNA expression profiles and antibody production in patients against <i>C. albicans</i> cell wall proteins.<sup id="cite_ref-auto2_124-1" class="reference"><a href="#cite_note-auto2-124"><span class="cite-bracket">[</span>124<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-131" class="reference"><a href="#cite_note-131"><span class="cite-bracket">[</span>131<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="GRACE_library">GRACE library</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=35" title="Edit section: GRACE library"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Using a <a href="/wiki/Tetracycline-controlled_transcriptional_activation" title="Tetracycline-controlled transcriptional activation">tetracycline-regulatable promoter system</a> a gene replacement and conditional expression (GRACE) library was created for 1,152 genes. By using the regulatable promoter and having deleted 1 of the alleles of the specific gene it was possible to discriminate between non-essential and essential genes. Of the tested 1,152 genes 567 showed to be essential. The knowledge on essential genes can be used to discover novel antifungals.<sup id="cite_ref-Large-scale_essential_gene_identifi_28-1" class="reference"><a href="#cite_note-Large-scale_essential_gene_identifi-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="CRISPR/Cas9"><span id="CRISPR.2FCas9"></span>CRISPR/Cas9</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=36" title="Edit section: CRISPR/Cas9"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/CRISPR" title="CRISPR">CRISPR/Cas9</a> has been adapted to be used in <i>C. albicans</i>.<sup id="cite_ref-132" class="reference"><a href="#cite_note-132"><span class="cite-bracket">[</span>132<span class="cite-bracket">]</span></a></sup> Several studies have been performed using this system.<sup id="cite_ref-133" class="reference"><a href="#cite_note-133"><span class="cite-bracket">[</span>133<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-134" class="reference"><a href="#cite_note-134"><span class="cite-bracket">[</span>134<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Application_in_engineering">Application in engineering</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=37" title="Edit section: Application in engineering"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>C. albicans</i> has been used in combination with carbon nanotubes (CNT) to produce stable electrically conductive bio-nano-composite tissue materials that have been used as temperature-sensing elements.<sup id="cite_ref-135" class="reference"><a href="#cite_note-135"><span class="cite-bracket">[</span>135<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Notable_C._albicans_researchers">Notable <i>C. albicans</i> researchers</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=38" title="Edit section: Notable C. albicans researchers"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Neil_A._R._Gow" class="mw-redirect" title="Neil A. R. Gow">Neil A. R. Gow</a></li> <li><a href="/wiki/Alexander_D._Johnson" title="Alexander D. Johnson">Alexander D. Johnson</a></li> <li><a href="/wiki/Frank_Odds" title="Frank Odds">Frank C. Odds</a></li> <li><a href="/wiki/Charles_Philippe_Robin" class="mw-redirect" title="Charles Philippe Robin">Charles Philippe Robin</a></li> <li><a href="/wiki/Fred_Sherman_(scientist)" title="Fred Sherman (scientist)">Fred Sherman</a></li> <li><a href="/wiki/David_R._Soll" title="David R. Soll">David R. Soll</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=39" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1259569809">.mw-parser-output .portalbox{padding:0;margin:0.5em 0;display:table;box-sizing:border-box;max-width:175px;list-style:none}.mw-parser-output .portalborder{border:1px solid var(--border-color-base,#a2a9b1);padding:0.1em;background:var(--background-color-neutral-subtle,#f8f9fa)}.mw-parser-output .portalbox-entry{display:table-row;font-size:85%;line-height:110%;height:1.9em;font-style:italic;font-weight:bold}.mw-parser-output .portalbox-image{display:table-cell;padding:0.2em;vertical-align:middle;text-align:center}.mw-parser-output .portalbox-link{display:table-cell;padding:0.2em 0.2em 0.2em 0.3em;vertical-align:middle}@media(min-width:720px){.mw-parser-output .portalleft{clear:left;float:left;margin:0.5em 1em 0.5em 0}.mw-parser-output .portalright{clear:right;float:right;margin:0.5em 0 0.5em 1em}}</style><ul role="navigation" aria-label="Portals" class="noprint portalbox portalborder portalright"> <li class="portalbox-entry"><span class="portalbox-image"><span class="noviewer" typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/42/Karl_Johanssvamp%2C_Iduns_kokbok.png/25px-Karl_Johanssvamp%2C_Iduns_kokbok.png" decoding="async" width="25" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/42/Karl_Johanssvamp%2C_Iduns_kokbok.png/38px-Karl_Johanssvamp%2C_Iduns_kokbok.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/42/Karl_Johanssvamp%2C_Iduns_kokbok.png/51px-Karl_Johanssvamp%2C_Iduns_kokbok.png 2x" data-file-width="1105" data-file-height="1215" /></span></span></span><span class="portalbox-link"><a href="/wiki/Portal:Fungi" title="Portal:Fungi">Fungi portal</a></span></li></ul> <ul><li><a href="/wiki/Intestinal_permeability" title="Intestinal permeability">Intestinal permeability</a></li> <li><a href="/wiki/Torula" title="Torula">Torula yeast</a> (<i>Candida utilis</i>)</li> <li><a href="/wiki/Neonatal_infection" title="Neonatal infection">Neonatal infection</a></li> <li><a href="/wiki/Codon_usage" class="mw-redirect" title="Codon usage">Codon usage</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=40" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=5476&lvl=3&lin=f&keep=1&srchmode=1&unlock">Candida albicans at NCBI Taxonomy browser</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20181215225924/https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=5476&lvl=3&lin=f&keep=1&srchmode=1&unlock">Archived</a> 2018-12-15 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a>, url accessed 2006-12-26</span> </li> <li id="cite_note-The_yeasts-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-The_yeasts_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-The_yeasts_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-The_yeasts_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output 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(2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052475">"Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension"</a>. <i>Pulmonary Circulation</i>. <b>10</b> (1): 111–114. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2013ITNan..12..111D">2013ITNan..12..111D</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1109%2FTNANO.2013.2239308">10.1109/TNANO.2013.2239308</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052475">7052475</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32166015">32166015</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:26949825">26949825</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pulmonary+Circulation&rft.atitle=Transcriptional+profiling+of+lung+cell+populations+in+idiopathic+pulmonary+arterial+hypertension&rft.volume=10&rft.issue=1&rft.pages=111-114&rft.date=2013&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7052475%23id-name%3DPMC&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A26949825%23id-name%3DS2CID&rft_id=info%3Abibcode%2F2013ITNan..12..111D&rft_id=info%3Apmid%2F32166015&rft_id=info%3Adoi%2F10.1109%2FTNANO.2013.2239308&rft.aulast=Saygin&rft.aufirst=D&rft.au=Tabib%2C+T&rft.au=Bittar%2C+HE&rft.au=Valenzi%2C+E&rft.au=Sembrat%2C+J&rft.au=Chan%2C+SY&rft.au=Rojas%2C+M&rft.au=Lafyatis%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7052475&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACandida+albicans" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=41" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOdds1988" class="citation book cs1">Odds FC (1988). <i>Candida and candidosis</i> (2nd ed.). Baillière Tindall. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0702012655" title="Special:BookSources/978-0702012655"><bdi>978-0702012655</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Candida+and+candidosis&rft.edition=2nd&rft.pub=Bailli%C3%A8re+Tindall&rft.date=1988&rft.isbn=978-0702012655&rft.aulast=Odds&rft.aufirst=FC&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACandida+albicans" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWaldmanGilharDuekBerdicevsky2001" class="citation journal cs1">Waldman A, Gilhar A, Duek L, Berdicevsky I (May 2001). "Incidence of Candida in psoriasis--a study on the fungal flora of psoriatic patients". <i>Mycoses</i>. <b>44</b> (3–4): 77–81. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1439-0507.2001.00608.x">10.1046/j.1439-0507.2001.00608.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11413927">11413927</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:36201859">36201859</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mycoses&rft.atitle=Incidence+of+Candida+in+psoriasis--a+study+on+the+fungal+flora+of+psoriatic+patients&rft.volume=44&rft.issue=3%E2%80%934&rft.pages=77-81&rft.date=2001-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A36201859%23id-name%3DS2CID&rft_id=info%3Apmid%2F11413927&rft_id=info%3Adoi%2F10.1046%2Fj.1439-0507.2001.00608.x&rft.aulast=Waldman&rft.aufirst=A&rft.au=Gilhar%2C+A&rft.au=Duek%2C+L&rft.au=Berdicevsky%2C+I&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACandida+albicans" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZordanMillerGalgoczyTuch2007" class="citation journal cs1">Zordan RE, Miller MG, Galgoczy DJ, Tuch BB, Johnson AD (October 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976629">"Interlocking transcriptional feedback loops control white-opaque switching in Candida albicans"</a>. <i>PLOS Biology</i>. <b>5</b> (10): e256. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pbio.0050256">10.1371/journal.pbio.0050256</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976629">1976629</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17880264">17880264</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+Biology&rft.atitle=Interlocking+transcriptional+feedback+loops+control+white-opaque+switching+in+Candida+albicans&rft.volume=5&rft.issue=10&rft.pages=e256&rft.date=2007-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1976629%23id-name%3DPMC&rft_id=info%3Apmid%2F17880264&rft_id=info%3Adoi%2F10.1371%2Fjournal.pbio.0050256&rft.aulast=Zordan&rft.aufirst=RE&rft.au=Miller%2C+MG&rft.au=Galgoczy%2C+DJ&rft.au=Tuch%2C+BB&rft.au=Johnson%2C+AD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1976629&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACandida+albicans" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRossignolLechatCuomoZeng2008" class="citation journal cs1">Rossignol T, Lechat P, Cuomo C, Zeng Q, Moszer I, d'Enfert C (January 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238939">"CandidaDB: a multi-genome database for Candida species and related Saccharomycotina"</a>. <i>Nucleic Acids Research</i>. <b>36</b> (Database issue): D557–D561. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fnar%2Fgkm1010">10.1093/nar/gkm1010</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238939">2238939</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18039716">18039716</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=CandidaDB%3A+a+multi-genome+database+for+Candida+species+and+related+Saccharomycotina&rft.volume=36&rft.issue=Database+issue&rft.pages=D557-D561&rft.date=2008-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2238939%23id-name%3DPMC&rft_id=info%3Apmid%2F18039716&rft_id=info%3Adoi%2F10.1093%2Fnar%2Fgkm1010&rft.aulast=Rossignol&rft.aufirst=T&rft.au=Lechat%2C+P&rft.au=Cuomo%2C+C&rft.au=Zeng%2C+Q&rft.au=Moszer%2C+I&rft.au=d%27Enfert%2C+C&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2238939&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACandida+albicans" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=coffeebrk.chapter.20">"How Candida albicans switches phenotype – and back again: the SIR2 silencing gene has a say in Candida's colony type"</a>. <i>NCBI Coffeebreak</i>. 1999-11-24<span class="reference-accessdate">. Retrieved <span class="nowrap">2008-11-02</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NCBI+Coffeebreak&rft.atitle=How+Candida+albicans+switches+phenotype+%E2%80%93+and+back+again%3A+the+SIR2+silencing+gene+has+a+say+in+Candida%27s+colony+type&rft.date=1999-11-24&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fbooks%2Fbv.fcgi%3Fcall%3Dbv.View..ShowSection%26rid%3Dcoffeebrk.chapter.20&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACandida+albicans" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Candida_albicans&action=edit&section=42" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1235681985">.mw-parser-output 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href="http://www.candidagenome.org/cache/Labs.html">Labs working on Candida</a></li> <li><a rel="nofollow" class="external text" href="https://thebiogrid.org">Protein-protein interactions for Candida albicans</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist 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abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Mycoses" title="Template:Mycoses"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Mycoses" title="Template talk:Mycoses"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Mycoses" title="Special:EditPage/Template:Mycoses"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Fungal_infection_and_mesomycetozoea" style="font-size:114%;margin:0 4em"><a href="/wiki/Mycosis" class="mw-redirect" title="Mycosis">Fungal infection</a> and <a href="/wiki/Mesomycetozoea" class="mw-redirect" title="Mesomycetozoea">mesomycetozoea</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mycosis#Superficial_mycoses" class="mw-redirect" title="Mycosis">Superficial</a> and<br /><a href="/wiki/Mycosis#Cutaneous_mycoses" class="mw-redirect" title="Mycosis">cutaneous</a><br />(<a href="/wiki/Dermatomycosis" title="Dermatomycosis">dermatomycosis</a>):<br /> <a href="/wiki/Tinea" class="mw-redirect" title="Tinea">Tinea</a> = <a href="/wiki/Human_skin" title="Human skin">skin</a>;<br /><a href="/wiki/Piedra" title="Piedra">Piedra</a> (<a href="/wiki/Exothrix" title="Exothrix">exothrix</a>/<br /><a href="/wiki/Endothrix" title="Endothrix">endothrix</a>) = <a href="/wiki/Hair" title="Hair">hair</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ascomycota" title="Ascomycota">Ascomycota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dermatophyte" title="Dermatophyte">Dermatophyte</a><br />(<a href="/wiki/Dermatophytosis" title="Dermatophytosis">Dermatophytosis</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">By location</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tinea_barbae" title="Tinea barbae">Tinea barbae</a>/<a href="/wiki/Tinea_capitis" title="Tinea capitis">tinea capitis</a> <ul><li><a href="/wiki/Kerion" title="Kerion">Kerion</a></li></ul></li> <li><a href="/wiki/Tinea_corporis" title="Tinea corporis">Tinea corporis</a> <ul><li><a href="/wiki/Dermatophytosis" title="Dermatophytosis">Ringworm</a></li> <li><a href="/wiki/Dermatophytid" title="Dermatophytid">Dermatophytids</a></li></ul></li> <li><a href="/wiki/Tinea_cruris" title="Tinea cruris">Tinea cruris</a></li> <li><a href="/wiki/Tinea_manuum" title="Tinea manuum">Tinea manuum</a></li> <li><a href="/wiki/Athlete%27s_foot" title="Athlete's foot">Tinea pedis (athlete's foot)</a></li> <li><a href="/wiki/Onychomycosis" title="Onychomycosis">Tinea unguium/onychomycosis</a> <ul><li><a href="/wiki/White_superficial_onychomycosis" title="White superficial onychomycosis">White superficial onychomycosis</a></li> <li><a href="/wiki/Distal_subungual_onychomycosis" title="Distal subungual onychomycosis">Distal subungual onychomycosis</a></li> <li><a href="/wiki/Proximal_subungual_onychomycosis" title="Proximal subungual onychomycosis">Proximal subungual onychomycosis</a></li></ul></li> <li><a href="/wiki/Tinea_corporis_gladiatorum" class="mw-redirect" title="Tinea corporis gladiatorum">Tinea corporis gladiatorum</a></li> <li><a href="/wiki/Tinea_faciei" title="Tinea faciei">Tinea faciei</a></li> <li><a href="/wiki/Tinea_imbricata" title="Tinea imbricata">Tinea imbricata</a></li> <li><a href="/wiki/Tinea_incognito" class="mw-redirect" title="Tinea incognito">Tinea incognito</a></li> <li><a href="/wiki/Favus" title="Favus">Favus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By organism</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Epidermophyton_floccosum" title="Epidermophyton floccosum">Epidermophyton floccosum</a></i></li> <li><i><a href="/wiki/Microsporum_canis" title="Microsporum canis">Microsporum canis</a></i></li> <li><i><a href="/wiki/Microsporum_audouinii" title="Microsporum audouinii">Microsporum audouinii</a></i></li> <li><i><a href="/wiki/Trichophyton_interdigitale" title="Trichophyton interdigitale">Trichophyton interdigitale/mentagrophytes</a></i></li> <li><i><a href="/wiki/Trichophyton_tonsurans" title="Trichophyton tonsurans">Trichophyton tonsurans</a></i></li> <li><i><a href="/wiki/Trichophyton" title="Trichophyton">Trichophyton schoenleini</a></i></li> <li><i><a href="/wiki/Trichophyton_rubrum" title="Trichophyton rubrum">Trichophyton rubrum</a></i></li> <li><i><a href="/wiki/Trichophyton_verrucosum" title="Trichophyton verrucosum">Trichophyton verrucosum</a></i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Hortaea_werneckii" title="Hortaea werneckii">Hortaea werneckii</a></i> <ul><li><a href="/wiki/Tinea_nigra" title="Tinea nigra">Tinea nigra</a></li></ul></li> <li><i><a href="/wiki/Piedraia_hortae" title="Piedraia hortae">Piedraia hortae</a></i> <ul><li><a href="/wiki/Black_piedra" class="mw-redirect" title="Black piedra">Black piedra</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Basidiomycota" title="Basidiomycota">Basidiomycota</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Malassezia" title="Malassezia">Malassezia furfur</a></i> <ul><li><a href="/wiki/Tinea_versicolor" title="Tinea versicolor">Tinea versicolor</a></li> <li><a href="/wiki/Malassezia_folliculitis" title="Malassezia folliculitis">Malassezia folliculitis</a></li></ul></li> <li><i><a href="/wiki/Trichosporon" title="Trichosporon">Trichosporon</a></i> <ul><li><a href="/wiki/White_piedra" title="White piedra">White piedra</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mycosis#Subcutaneous_mycoses" class="mw-redirect" title="Mycosis">Subcutaneous</a>,<br /><a href="/wiki/Mycosis#Systemic_mycoses_due_to_primary_pathogens" class="mw-redirect" title="Mycosis">systemic</a>,<br />and <a href="/wiki/Mycosis#Systemic_mycoses_due_to_opportunistic_pathogens" class="mw-redirect" title="Mycosis">opportunistic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ascomycota" title="Ascomycota">Ascomycota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dimorphic_fungus" title="Dimorphic fungus">Dimorphic</a><br />(yeast+mold)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Onygenales" title="Onygenales">Onygenales</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Coccidioides_immitis" title="Coccidioides immitis">Coccidioides immitis</a>/<a href="/wiki/Coccidioides_posadasii" title="Coccidioides posadasii">Coccidioides posadasii</a></i> <ul><li><a href="/wiki/Coccidioidomycosis" title="Coccidioidomycosis">Coccidioidomycosis</a></li> <li><a href="/wiki/Disseminated_coccidioidomycosis" title="Disseminated coccidioidomycosis">Disseminated coccidioidomycosis</a></li> <li><a href="/wiki/Primary_cutaneous_coccidioidomycosis" title="Primary cutaneous coccidioidomycosis">Primary cutaneous coccidioidomycosis</a>. <a href="/wiki/Primary_pulmonary_coccidioidomycosis" title="Primary pulmonary coccidioidomycosis">Primary pulmonary coccidioidomycosis</a></li></ul></li> <li><i><a href="/wiki/Histoplasma_capsulatum" title="Histoplasma capsulatum">Histoplasma capsulatum</a></i> <ul><li><a href="/wiki/Histoplasmosis" title="Histoplasmosis">Histoplasmosis</a></li> <li><a href="/wiki/Primary_cutaneous_histoplasmosis" title="Primary cutaneous histoplasmosis">Primary cutaneous histoplasmosis</a></li> <li><a href="/wiki/Primary_pulmonary_histoplasmosis" title="Primary pulmonary histoplasmosis">Primary pulmonary histoplasmosis</a></li> <li><a href="/wiki/Progressive_disseminated_histoplasmosis" title="Progressive disseminated histoplasmosis">Progressive disseminated histoplasmosis</a></li></ul></li> <li><i><a href="/wiki/Histoplasma_duboisii" title="Histoplasma duboisii">Histoplasma duboisii</a></i> <ul><li><a href="/wiki/African_histoplasmosis" title="African histoplasmosis">African histoplasmosis</a></li></ul></li> <li><i><a href="/wiki/Lacazia" title="Lacazia">Lacazia loboi</a></i> <ul><li><a href="/wiki/Lobomycosis" title="Lobomycosis">Lobomycosis</a></li></ul></li> <li><i><a href="/wiki/Paracoccidioides_brasiliensis" title="Paracoccidioides brasiliensis">Paracoccidioides brasiliensis</a></i> <ul><li><a href="/wiki/Paracoccidioidomycosis" title="Paracoccidioidomycosis">Paracoccidioidomycosis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Blastomyces_dermatitidis" title="Blastomyces dermatitidis">Blastomyces dermatitidis</a></i> <ul><li><a href="/wiki/Blastomycosis" title="Blastomycosis">Blastomycosis</a></li> <li><a href="/wiki/Blastomycosis" title="Blastomycosis">North American blastomycosis</a></li> <li><a href="/wiki/Paracoccidioidomycosis" title="Paracoccidioidomycosis">South American blastomycosis</a></li></ul></li> <li><i><a href="/wiki/Sporothrix_schenckii" title="Sporothrix schenckii">Sporothrix schenckii</a></i> <ul><li><a href="/wiki/Sporotrichosis" title="Sporotrichosis">Sporotrichosis</a></li></ul></li> <li><i><a href="/wiki/Talaromyces_marneffei" title="Talaromyces marneffei">Talaromyces marneffei</a></i> <ul><li><a href="/wiki/Talaromycosis" title="Talaromycosis">Talaromycosis</a></li></ul></li> <li><a href="/wiki/Scedosporiosis" title="Scedosporiosis">Scedosporiosis</a></li> <li><a href="/wiki/Emmonsiosis" title="Emmonsiosis">Emmonsiosis</a></li> <li><i><a href="/wiki/Emmonsia_parva" title="Emmonsia parva">Emmonsia parva</a></i> <ul><li><a href="/w/index.php?title=Adiaspiromycosis&action=edit&redlink=1" class="new" title="Adiaspiromycosis (page does not exist)">Adiaspiromycosis</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Yeast" title="Yeast">Yeast</a>-like</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a class="mw-selflink selflink">Candida albicans</a></i> <ul><li><a href="/wiki/Candidiasis" title="Candidiasis">Candidiasis</a></li> <li><a href="/wiki/Oral_candidiasis" title="Oral candidiasis">Oral</a></li> <li><a href="/wiki/Esophageal_candidiasis" title="Esophageal candidiasis">Esophageal</a></li> <li><a href="/wiki/Candidal_vulvovaginitis" class="mw-redirect" title="Candidal vulvovaginitis">Vulvovaginal</a></li> <li><a href="/wiki/Chronic_mucocutaneous_candidiasis" title="Chronic mucocutaneous candidiasis">Chronic mucocutaneous</a></li> <li><a href="/wiki/Antibiotic_candidiasis" class="mw-redirect" title="Antibiotic candidiasis">Antibiotic candidiasis</a></li> <li><a href="/wiki/Candidal_intertrigo" title="Candidal intertrigo">Candidal intertrigo</a></li> <li><a href="/wiki/Candidal_onychomycosis" title="Candidal onychomycosis">Candidal onychomycosis</a></li> <li><a href="/wiki/Paronychia" title="Paronychia">Candidal paronychia</a></li> <li><a href="/wiki/Candidid" title="Candidid">Candidid</a></li> <li><a href="/wiki/Diaper_candidiasis" class="mw-redirect" title="Diaper candidiasis">Diaper candidiasis</a></li> <li><a href="/wiki/Congenital_cutaneous_candidiasis" title="Congenital cutaneous candidiasis">Congenital cutaneous candidiasis</a></li> <li><a href="/wiki/Perianal_candidiasis" class="mw-redirect" title="Perianal candidiasis">Perianal candidiasis</a></li> <li><a href="/wiki/Systemic_candidiasis" class="mw-redirect" title="Systemic candidiasis">Systemic candidiasis</a></li> <li><a href="/wiki/Erosio_interdigitalis_blastomycetica" title="Erosio interdigitalis blastomycetica">Erosio interdigitalis blastomycetica</a></li></ul></li> <li><i><a href="/wiki/Candida_auris" title="Candida auris">C. auris</a></i></li> <li><i><a href="/wiki/Candida_glabrata" class="mw-redirect" title="Candida glabrata">C. glabrata</a></i></li> <li><i><a href="/wiki/Candida_lusitaniae" class="mw-redirect" title="Candida lusitaniae">C. lusitaniae</a></i></li> <li><i><a href="/wiki/Candida_tropicalis" title="Candida tropicalis">C. tropicalis</a></i></li> <li><i><a href="/wiki/Pneumocystis_jirovecii" title="Pneumocystis jirovecii">Pneumocystis jirovecii</a></i> <ul><li><a href="/wiki/Pneumocystosis" title="Pneumocystosis">Pneumocystosis</a></li> <li><a href="/wiki/Pneumocystis_pneumonia" title="Pneumocystis pneumonia">Pneumocystis pneumonia</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mold_(fungus)" class="mw-redirect" title="Mold (fungus)">Mold</a>-like</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Aspergillus" title="Aspergillus">Aspergillus</a></i> <ul><li><a href="/wiki/Aspergillosis" title="Aspergillosis">Aspergillosis</a></li> <li><a href="/wiki/Aspergilloma" title="Aspergilloma">Aspergilloma</a></li> <li><a href="/wiki/Allergic_bronchopulmonary_aspergillosis" title="Allergic bronchopulmonary aspergillosis">Allergic bronchopulmonary aspergillosis</a></li> <li><a href="/wiki/Primary_cutaneous_aspergillosis" title="Primary cutaneous aspergillosis">Primary cutaneous aspergillosis</a></li></ul></li> <li><i><a href="/wiki/Exophiala_jeanselmei" title="Exophiala jeanselmei">Exophiala jeanselmei</a></i> <ul><li><a href="/wiki/Eumycetoma" title="Eumycetoma">Eumycetoma</a></li></ul></li> <li><i><a href="/wiki/Fonsecaea_pedrosoi" title="Fonsecaea pedrosoi">Fonsecaea pedrosoi</a>/<a href="/wiki/Fonsecaea_compacta" title="Fonsecaea compacta">Fonsecaea compacta</a>/<a href="/wiki/Phialophora_verrucosa" title="Phialophora verrucosa">Phialophora verrucosa</a></i> <ul><li><a href="/wiki/Chromoblastomycosis" title="Chromoblastomycosis">Chromoblastomycosis</a></li></ul></li> <li><i><a href="/wiki/Geotrichum_candidum" title="Geotrichum candidum">Geotrichum candidum</a></i> <ul><li><a href="/wiki/Geotrichosis" title="Geotrichosis">Geotrichosis</a></li></ul></li> <li><i><a href="/wiki/Pseudallescheria_boydii" title="Pseudallescheria boydii">Pseudallescheria boydii</a></i> <ul><li><a href="/wiki/Pseudallescheria_boydii" title="Pseudallescheria boydii">Allescheriasis</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Basidiomycota" title="Basidiomycota">Basidiomycota</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Cryptococcus_neoformans" title="Cryptococcus neoformans">Cryptococcus neoformans</a></i> <ul><li><a href="/wiki/Cryptococcosis" title="Cryptococcosis">Cryptococcosis</a></li> <li><i><a href="/wiki/Trichosporon" title="Trichosporon">Trichosporon</a></i> spp</li> <li><a href="/wiki/Trichosporonosis" title="Trichosporonosis">Trichosporonosis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Zygomycota" title="Zygomycota">Zygomycota</a><br /> (<a href="/wiki/Zygomycosis" title="Zygomycosis">Zygomycosis</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mucorales" title="Mucorales">Mucorales</a><br /> (<a href="/wiki/Mucormycosis" title="Mucormycosis">Mucormycosis</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Rhizopus_oryzae" title="Rhizopus oryzae">Rhizopus oryzae</a></i></li> <li><i><a href="/wiki/Mucor_indicus" title="Mucor indicus">Mucor indicus</a></i></li> <li><i><a href="/wiki/Lichtheimia_corymbifera" title="Lichtheimia corymbifera">Lichtheimia corymbifera</a></i></li> <li><i><a href="/wiki/Syncephalastrum_racemosum" title="Syncephalastrum racemosum">Syncephalastrum racemosum</a></i></li> <li><i><a href="/wiki/Apophysomyces_variabilis" title="Apophysomyces variabilis">Apophysomyces variabilis</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Entomophthorales" title="Entomophthorales">Entomophthorales</a><br /> (<a href="/wiki/Entomophthoramycosis" title="Entomophthoramycosis">Entomophthoramycosis</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Basidiobolus_ranarum" title="Basidiobolus ranarum">Basidiobolus ranarum</a></i> <ul><li><a href="/wiki/Basidiobolomycosis" title="Basidiobolomycosis">Basidiobolomycosis</a></li></ul></li> <li><i><a href="/wiki/Conidiobolus_coronatus" title="Conidiobolus coronatus">Conidiobolus coronatus</a>/<a href="/wiki/Conidiobolus_incongruus" title="Conidiobolus incongruus">Conidiobolus incongruus</a></i> <ul><li><a href="/wiki/Conidiobolomycosis" title="Conidiobolomycosis">Conidiobolomycosis</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Microsporidia" title="Microsporidia">Microsporidia</a><br /> (<a href="/wiki/Microsporidiosis" title="Microsporidiosis">Microsporidiosis</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Enterocytozoon_bieneusi" title="Enterocytozoon bieneusi">Enterocytozoon bieneusi</a>/<a href="/wiki/Encephalitozoon_intestinalis" title="Encephalitozoon intestinalis">Encephalitozoon intestinalis</a></i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mesomycetozoea" class="mw-redirect" title="Mesomycetozoea">Mesomycetozoea</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Rhinosporidium_seeberi" title="Rhinosporidium seeberi">Rhinosporidium seeberi</a></i> <ul><li><a href="/wiki/Rhinosporidiosis" title="Rhinosporidiosis">Rhinosporidiosis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alternariosis" title="Alternariosis">Alternariosis</a></li> <li><a href="/wiki/Fungal_folliculitis" title="Fungal folliculitis">Fungal folliculitis</a></li> <li><i><a href="/wiki/Fusarium" title="Fusarium">Fusarium</a></i> <ul><li><a href="/wiki/Fusariosis" title="Fusariosis">Fusariosis</a></li></ul></li> <li><a href="/wiki/Granuloma_gluteale_infantum" title="Granuloma gluteale infantum">Granuloma gluteale infantum</a></li> <li><a href="/wiki/Hyalohyphomycosis" title="Hyalohyphomycosis">Hyalohyphomycosis</a></li> <li><a href="/wiki/Otomycosis" title="Otomycosis">Otomycosis</a></li> <li><a href="/wiki/Keratomycosis" class="mw-redirect" title="Keratomycosis">Keratomycosis</a></li> <li><a href="/wiki/Phaeohyphomycosis" title="Phaeohyphomycosis">Phaeohyphomycosis</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Taxon_identifiers" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Taxon_identifiers" style="font-size:114%;margin:0 4em"><a href="/wiki/Help:Taxon_identifiers" title="Help:Taxon identifiers">Taxon identifiers</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: left;"><i>Candida albicans</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><span style="white-space:nowrap;"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a>: <span class="uid"><span class="external"><a href="https://www.wikidata.org/wiki/Q310443" class="extiw" title="wikidata:Q310443">Q310443</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Wikispecies" title="Wikispecies">Wikispecies</a>: <span class="uid"><span class="external"><a href="https://species.wikimedia.org/wiki/Candida_albicans" class="extiw" title="wikispecies:Candida albicans">Candida albicans</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Australian_online_fauna_%26_flora_databases" title="Australian online fauna & flora databases">AusFungi</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://id.biodiversity.org.au/name/fungi/60022019">60022019</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Catalogue_of_Life" title="Catalogue of Life">CoL</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.catalogueoflife.org/data/taxon/699T3">699T3</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Encyclopedia_of_Life" title="Encyclopedia of Life">EoL</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://eol.org/pages/1013921">1013921</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/EPPO_Code" title="EPPO Code">EPPO</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://gd.eppo.int/taxon/CANDAL">CANDAL</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Global_Biodiversity_Information_Facility" title="Global Biodiversity Information Facility">GBIF</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.gbif.org/species/2599597">2599597</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/INaturalist" title="INaturalist">iNaturalist</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://inaturalist.org/taxa/895618">895618</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">IndexFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.indexfungorum.org/names/NamesRecord.asp?RecordID=256187">256187</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Interim_Register_of_Marine_and_Nonmarine_Genera" title="Interim Register of Marine and Nonmarine Genera">IRMNG</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.irmng.org/aphia.php?p=taxdetails&id=10482576">10482576</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Integrated_Taxonomic_Information_System" title="Integrated Taxonomic Information System">ITIS</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=194598">194598</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/MycoBank" title="MycoBank">MycoBank</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.mycobank.org/MB/256187">256187</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/National_Biodiversity_Network" title="National Biodiversity Network">NBN</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://species.nbnatlas.org/species/BMSSYS0000003266">BMSSYS0000003266</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=5476">5476</a></span></span></li> <li><span style="white-space:nowrap;">NZOR: <span class="uid"><a rel="nofollow" class="external text" href="https://www.nzor.org.nz/names/b68ca8b8-874a-49f7-9ff7-a62b630b0c79">b68ca8b8-874a-49f7-9ff7-a62b630b0c79</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Open_Tree_of_Life" title="Open Tree of Life">Open Tree of Life</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://tree.opentreeoflife.org/taxonomy/browse?id=154960">154960</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">SpeciesFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.speciesfungorum.org/Names/NamesRecord.asp?RecordID=256187">256187</a></span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: left;"><i>Oidium albicans</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><span style="white-space:nowrap;"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a>: <span class="uid"><span class="external"><a href="https://www.wikidata.org/wiki/Q59452981" class="extiw" title="wikidata:Q59452981">Q59452981</a></span></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Australian_online_fauna_%26_flora_databases" title="Australian online fauna & flora databases">AusFungi</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://id.biodiversity.org.au/name/fungi/60022020">60022020</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Catalogue_of_Life" title="Catalogue of Life">CoL</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.catalogueoflife.org/data/taxon/48ZN5">48ZN5</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Global_Biodiversity_Information_Facility" title="Global Biodiversity Information Facility">GBIF</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.gbif.org/species/2599599">2599599</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">IndexFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="http://www.indexfungorum.org/names/NamesRecord.asp?RecordID=247312">247312</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Interim_Register_of_Marine_and_Nonmarine_Genera" title="Interim Register of Marine and Nonmarine Genera">IRMNG</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.irmng.org/aphia.php?p=taxdetails&id=11304730">11304730</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/MycoBank" title="MycoBank">MycoBank</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.mycobank.org/MB/247312">247312</a></span></span></li> <li><span style="white-space:nowrap;">NZOR: <span class="uid"><a rel="nofollow" class="external text" href="https://www.nzor.org.nz/names/b7ae58a4-9f40-4b87-aea9-01bcd7b10b59">b7ae58a4-9f40-4b87-aea9-01bcd7b10b59</a></span></span></li> <li><span style="white-space:nowrap;"><a href="/wiki/Index_Fungorum" title="Index Fungorum">SpeciesFungorum</a>: <span class="uid"><a rel="nofollow" class="external text" href="https://www.speciesfungorum.org/Names/NamesRecord.asp?RecordID=247312">247312</a></span></span></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r1038841319">.mw-parser-output .tooltip-dotted{border-bottom:1px dotted;cursor:help}</style></div><div role="navigation" class="navbox authority-control" aria-label="Navbox" style="padding:3px"><table 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