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data-track-context="journal title in journal masthead on a journal page" data-track-category="journal masthead" data-track-action="click journal title"> <h1 class="app-journal-masthead__title">Acta Neuropathologica</h1> </a> <p data-test="darwin-journal-subtitle" class="app-journal-masthead__subtitle">Pathology and Mechanisms of Neurological Disease</p> <div class="app-journal-masthead__publishing-model" data-test="darwin-publishing-model"> <dl> <dt>Publishing model<span class="app-journal-masthead__publishing-model-colon">:</span></dt> <dd class="app-journal-masthead__publishing-model-link">Hybrid</dd> </dl> </div> </div> <div class="app-journal-masthead__button"> <a href="https://submission.springernature.com/new-submission/401/3" data-track="click_submit_manuscript" data-track-category="Journal" data-track-action="manuscript submission" data-track-context="journal masthead on journal pages" data-track-label="Acta Neuropathologica" class="eds-c-button eds-c-button--secondary"> <span>Submit your manuscript</span><svg aria-hidden="true" focusable="false"><use xlink:href="#icon-eds-i-arrow-right-small"></use></svg> </a> </div> </div> </div> </div> </section> </div> <div class="u-container u-mt-16"> <div class="app-page-layout app-page-layout--navigation"> <div class="app-page-layout__main app-page-layout__main--mb-0" data-test="journal-homepage-navigation"> <nav class="app-journal-nav" data-ga="journal-homepage-navigation" aria-label="journal navigation"> <ul class="app-journal-nav__list"> <li class="app-journal-nav__item"> <a href="/journal/401/aims-and-scope?error=cookies_not_supported&code=709d4665-df84-47ab-8cc6-82e95ddc7657" data-track="nav_aims_and_scope" data-track-category="journal home navigation" data-track-action="click aims and scope" data-track-context="nav buttons below journal masthead" class="eds-c-button eds-c-button--tertiary eds-c-button--small"> <svg aria-hidden="true" focusable="false"><use 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aria-hidden="true" focusable="false"><use xlink:href="#icon-eds-i-news-medium"></use></svg><span>Journal updates</span> </a> </li> </ul> </nav> </div> </div> <div class="app-page-layout app-page-layout--listing-content"> <main class="app-page-layout__main" id="main"> <section> <h2 class="u-mb-16 u-mt-0">Overview</h2> <div class="app-journal-overview"> <div> <div class="app-journal-overview__promo-text c-list-bullets c-list-bullets--no-spacing" data-test="darwin-journal-homepage-promo-text"> <p>Acta Neuropathologica麓s mission is to publish the best articles on pathology and pathogenesis of neurological disease. The journal focuses on structural and molecular neuropathology using human tissue, animal models and in vitro systems.</p> <p>The journal publishes Original Papers, Review Articles, Case Reports and Scientific Correspondence.</p> <p>Five reasons for publishing your best paper in Acta Neuropathologica:</p> <ul> <li>High impact: 12.7 (IF 2022)</li> <li>Wide distribution: more than 10,000 institutions worldwide having full text access.</li> <li>Efficient handling: 9 days between submission and first decision.</li> <li>Fast publication: 10 days between acceptance and online publication.</li> <li>Commitment to fairness: author feedback program.</li> </ul> </div> </div> <dl class="app-journal-overview__editor" data-test="journal-editor-links"> <dt>Editor-in-Chief</dt> <dd> <ul class="u-list-reset"> <li class="u-display-inline">Johannes Attems</li> </ul> </dd> </dl> <div class="app-journal-overview__metrics"> <div class="app-journal-overview__metric"> <span class="app-journal-overview__metric-icon-container"> <svg class="app-journal-overview__metric-icon" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-impact-factor-medium"></use> </svg> </span> <dl> <dt data-test="impact-factor-label" class="app-journal-overview__metric-label">Journal Impact Factor</dt> <dd data-test="impact-factor-value" class="app-journal-overview__metric-value"><b>9.3 (2023)</b></dd> </dl> </div> <div class="app-journal-overview__metric"> <span class="app-journal-overview__metric-icon-container"> <svg class="app-journal-overview__metric-icon" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-calendar-impact-factor-medium"></use> </svg> </span> <dl> <dt data-test="five-year-impact-factor-label" class="app-journal-overview__metric-label">5-year Journal Impact Factor</dt> <dd data-test="five-year-impact-factor-value" class="app-journal-overview__metric-value"><b>13.2 (2023)</b></dd> </dl> </div> <div class="app-journal-overview__metric"> <span class="app-journal-overview__metric-icon-container"> <svg class="app-journal-overview__metric-icon" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-calendar-decision-medium"></use> </svg> </span> <dl> <dt data-test="metrics-speed-label" class="app-journal-overview__metric-label">Submission to first decision (median)</dt> <dd data-test="metrics-speed-value" class="app-journal-overview__metric-value">1 days</dd> </dl> </div> <div class="app-journal-overview__metric"> <span class="app-journal-overview__metric-icon-container"> <svg class="app-journal-overview__metric-icon" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-file-download-medium"></use> </svg> </span> <dl> <dt data-test="metrics-downloads-label" class="app-journal-overview__metric-label">Downloads</dt> <dd data-test="metrics-downloads-value" class="app-journal-overview__metric-value">1,896,327 (2023)</dd> </dl> </div> </div> </div> </section> <div class="app-reading-width"> <section data-ga="latest-articles"> <h2 class="u-mb-16 u-mt-0 u-h3">Latest articles</h2> <div> <ol class="u-list-reset"> <li> <article class="app-card-open app-card-open--has-image"> <div class="app-card-open__main"> <div class="app-entitlement"> <div class="c-meta"> </div> </div> <h3 class="app-card-open__heading"> <a href="https://link.springer.com/article/10.1007/s00401-024-02839-2" data-track="select_latest_article" data-track-context="journal homepage latest articles section" data-track-category="latest articles" data-track-action="clicked article" data-track-label="" >Amyloid-尾 oligomers increase the binding and internalization of tau oligomers in human synapses</a> </h3> <div class="app-card-open__text-container"> <div class="app-card-open__authors"><span><ul class="c-author-list c-author-list--truncated c-author-list--compact"> <li class="c-author-list__item">Shrinath Kadamangudi</li><li class="c-author-list__item">Michela Marcatti</li><li class="c-author-list__item">Giulio Taglialatela</li> </ul></span></div> <div class="app-card-open__meta" data-test="meta"> <div class="c-meta"> <span class="c-meta__item c-meta__type"> Original Paper </span> <span class="c-meta__item"> Open access </span> <span class="c-meta__item"> 17 December 2024 </span> <span class="c-meta__item"> Article: 2 </span> </div> </div> </div> </div> <div class="app-card-open__side"> <picture> <source type="image/webp" media="(min-width: 1024px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02839-2/MediaObjects/401_2024_2839_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02839-2/MediaObjects/401_2024_2839_Fig1_HTML.png?as=webp 2x"> <source type="image/webp" media="(min-width: 480px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02839-2/MediaObjects/401_2024_2839_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02839-2/MediaObjects/401_2024_2839_Fig1_HTML.png?as=webp 2x"> <img loading="lazy" src="https://media.springernature.com/w110h61/springer-static/image/art%3A10.1007%2Fs00401-024-02839-2/MediaObjects/401_2024_2839_Fig1_HTML.png?as=jpg" width="110" height="61" srcset="https://media.springernature.com/w220h122/springer-static/image/art%3A10.1007%2Fs00401-024-02839-2/MediaObjects/401_2024_2839_Fig1_HTML.png?as=jpg 2x" alt=""> </picture> </div> </article> </li> <li> <article class="app-card-open app-card-open--has-image"> <div class="app-card-open__main"> <div class="app-entitlement"> <div class="c-meta"> </div> </div> <h3 class="app-card-open__heading"> <a href="https://link.springer.com/article/10.1007/s00401-024-02840-9" data-track="select_latest_article" data-track-context="journal homepage latest articles section" data-track-category="latest articles" data-track-action="clicked article" data-track-label="" >TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury</a> </h3> <div class="app-card-open__text-container"> <div class="app-card-open__authors"><span><ul class="c-author-list c-author-list--truncated c-author-list--compact"> <li class="c-author-list__item">Beate Hartmannsberger</li><li class="c-author-list__item">Adel Ben-Kraiem</li><li class="c-author-list__item">Heike L. Rittner</li> </ul></span></div> <div class="app-card-open__meta" data-test="meta"> <div class="c-meta"> <span class="c-meta__item c-meta__type"> Original Paper </span> <span class="c-meta__item"> Open access </span> <span class="c-meta__item"> 16 December 2024 </span> <span class="c-meta__item"> Article: 1 </span> </div> </div> </div> </div> <div class="app-card-open__side"> <picture> <source type="image/webp" media="(min-width: 1024px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02840-9/MediaObjects/401_2024_2840_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02840-9/MediaObjects/401_2024_2840_Fig1_HTML.png?as=webp 2x"> <source type="image/webp" media="(min-width: 480px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02840-9/MediaObjects/401_2024_2840_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02840-9/MediaObjects/401_2024_2840_Fig1_HTML.png?as=webp 2x"> <img loading="lazy" src="https://media.springernature.com/w110h61/springer-static/image/art%3A10.1007%2Fs00401-024-02840-9/MediaObjects/401_2024_2840_Fig1_HTML.png?as=jpg" width="110" height="61" srcset="https://media.springernature.com/w220h122/springer-static/image/art%3A10.1007%2Fs00401-024-02840-9/MediaObjects/401_2024_2840_Fig1_HTML.png?as=jpg 2x" alt=""> </picture> </div> </article> </li> <li> <article class="app-card-open app-card-open--has-image"> <div class="app-card-open__main"> <div class="app-entitlement"> <div class="c-meta"> </div> </div> <h3 class="app-card-open__heading"> <a href="https://link.springer.com/article/10.1007/s00401-024-02823-w" data-track="select_latest_article" data-track-context="journal homepage latest articles section" data-track-category="latest articles" data-track-action="clicked article" data-track-label="" >Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy</a> </h3> <div class="app-card-open__text-container"> <div class="app-card-open__authors"><span><ul class="c-author-list c-author-list--truncated c-author-list--compact"> <li class="c-author-list__item">Kristen Whitney</li><li class="c-author-list__item">Won-Min Song</li><li class="c-author-list__item">John F. Crary</li> </ul></span></div> <div class="app-card-open__meta" data-test="meta"> <div class="c-meta"> <span class="c-meta__item c-meta__type"> Original Paper </span> <span class="c-meta__item"> Open access </span> <span class="c-meta__item"> 09 December 2024 </span> <span class="c-meta__item"> Article: 80 </span> </div> </div> </div> </div> <div class="app-card-open__side"> <picture> <source type="image/webp" media="(min-width: 1024px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02823-w/MediaObjects/401_2024_2823_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02823-w/MediaObjects/401_2024_2823_Fig1_HTML.png?as=webp 2x"> <source type="image/webp" media="(min-width: 480px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02823-w/MediaObjects/401_2024_2823_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02823-w/MediaObjects/401_2024_2823_Fig1_HTML.png?as=webp 2x"> <img loading="lazy" src="https://media.springernature.com/w110h61/springer-static/image/art%3A10.1007%2Fs00401-024-02823-w/MediaObjects/401_2024_2823_Fig1_HTML.png?as=jpg" width="110" height="61" srcset="https://media.springernature.com/w220h122/springer-static/image/art%3A10.1007%2Fs00401-024-02823-w/MediaObjects/401_2024_2823_Fig1_HTML.png?as=jpg 2x" alt=""> </picture> </div> </article> </li> <li> <article class="app-card-open app-card-open--has-image"> <div class="app-card-open__main"> <div class="app-entitlement"> <div class="c-meta"> </div> </div> <h3 class="app-card-open__heading"> <a href="https://link.springer.com/article/10.1007/s00401-024-02833-8" data-track="select_latest_article" data-track-context="journal homepage latest articles section" data-track-category="latest articles" data-track-action="clicked article" data-track-label="" >Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts</a> </h3> <div class="app-card-open__text-container"> <div class="app-card-open__authors"><span><ul class="c-author-list c-author-list--truncated c-author-list--compact"> <li class="c-author-list__item">Raymond Nicks</li><li class="c-author-list__item">Arsal Shah</li><li class="c-author-list__item">Thor D. Stein</li> </ul></span></div> <div class="app-card-open__meta" data-test="meta"> <div class="c-meta"> <span class="c-meta__item c-meta__type"> Original Paper </span> <span class="c-meta__item"> Open access </span> <span class="c-meta__item"> 06 December 2024 </span> <span class="c-meta__item"> Article: 79 </span> </div> </div> </div> </div> <div class="app-card-open__side"> <picture> <source type="image/webp" media="(min-width: 1024px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02833-8/MediaObjects/401_2024_2833_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02833-8/MediaObjects/401_2024_2833_Fig1_HTML.png?as=webp 2x"> <source type="image/webp" media="(min-width: 480px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02833-8/MediaObjects/401_2024_2833_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02833-8/MediaObjects/401_2024_2833_Fig1_HTML.png?as=webp 2x"> <img loading="lazy" src="https://media.springernature.com/w110h61/springer-static/image/art%3A10.1007%2Fs00401-024-02833-8/MediaObjects/401_2024_2833_Fig1_HTML.png?as=jpg" width="110" height="61" srcset="https://media.springernature.com/w220h122/springer-static/image/art%3A10.1007%2Fs00401-024-02833-8/MediaObjects/401_2024_2833_Fig1_HTML.png?as=jpg 2x" alt=""> </picture> </div> </article> </li> <li> <article class="app-card-open app-card-open--last app-card-open--has-image"> <div class="app-card-open__main"> <div class="app-entitlement"> <div class="c-meta"> </div> </div> <h3 class="app-card-open__heading"> <a href="https://link.springer.com/article/10.1007/s00401-024-02824-9" data-track="select_latest_article" data-track-context="journal homepage latest articles section" data-track-category="latest articles" data-track-action="clicked article" data-track-label="" >Identification of isoAsp7-A尾 as a major A尾 variant in Alzheimer鈥檚 disease, dementia with Lewy bodies and vascular dementia</a> </h3> <div class="app-card-open__text-container"> <div class="app-card-open__authors"><span><ul class="c-author-list c-author-list--truncated c-author-list--compact"> <li class="c-author-list__item">Sarah Schrempel</li><li class="c-author-list__item">Anna Katharina Kottwitz</li><li class="c-author-list__item">Steffen Ro脽ner</li> </ul></span></div> <div class="app-card-open__meta" data-test="meta"> <div class="c-meta"> <span class="c-meta__item c-meta__type"> Original Paper </span> <span class="c-meta__item"> Open access </span> <span class="c-meta__item"> 03 December 2024 </span> <span class="c-meta__item"> Article: 78 </span> </div> </div> </div> </div> <div class="app-card-open__side"> <picture> <source type="image/webp" media="(min-width: 1024px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02824-9/MediaObjects/401_2024_2824_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02824-9/MediaObjects/401_2024_2824_Fig1_HTML.png?as=webp 2x"> <source type="image/webp" media="(min-width: 480px)" width="190" height="106" srcset="https://media.springernature.com/w190h106/springer-static/image/art%3A10.1007%2Fs00401-024-02824-9/MediaObjects/401_2024_2824_Fig1_HTML.png?as=webp, https://media.springernature.com/w380h212/springer-static/image/art%3A10.1007%2Fs00401-024-02824-9/MediaObjects/401_2024_2824_Fig1_HTML.png?as=webp 2x"> <img loading="lazy" src="https://media.springernature.com/w110h61/springer-static/image/art%3A10.1007%2Fs00401-024-02824-9/MediaObjects/401_2024_2824_Fig1_HTML.png?as=jpg" width="110" height="61" srcset="https://media.springernature.com/w220h122/springer-static/image/art%3A10.1007%2Fs00401-024-02824-9/MediaObjects/401_2024_2824_Fig1_HTML.png?as=jpg 2x" alt=""> </picture> </div> </article> </li> </ol> <div class="app-latest-articles-ctas"> <div class="app-latest-articles-ctas__button" data-ga="view-all-articles-button"> <a href="/journal/401/articles?error=cookies_not_supported&code=709d4665-df84-47ab-8cc6-82e95ddc7657" data-track="click_all_articles" data-track-category="latest articles" data-track-action="click view all articles" data-track-context="journal homepage latest articles section" class="eds-c-button eds-c-button--secondary"> <span>View all articles</span><svg aria-hidden="true" focusable="false"><use xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> </div> <div class="app-latest-articles-ctas__message" data-test="total-oa-articles"> <span>This journal has</span> <a class="app-latest-articles-ctas__link" data-track="click_oa_articles" data-track-context="journal homepage latest articles section" data-track-category="latest articles" data-track-action="click open access articles" href="https://link.springer.com/search?query=&search-within=Journal&package=openaccessarticles&facet-journal-id=401"> <span>961 open access articles</span> <svg class="app-latest-articles-ctas__icon" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-arrow-right-small"></use> </svg> </a> </div> </div> </div> </section> </div> <div class="app-reading-width"> <section data-test="homepage-updates" data-ga="journal-updates"> <h2 class="u-mb-16 u-mt-0 u-h3" data-test="updates-heading">Journal updates</h2> <div data-fragment="16931710"> <ul data-test="updates" class="u-list-reset u-h3 l-stack c-list-bullets--hide" style="--stack--gap: 24px"> <li class="c-list-bullets c-list-bullets--no-spacing"> <article class="app-card-highlight"> <div class="app-card-highlight__main"> <div class="app-card-highlight__content"> <h3 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