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Katy Poncin, Christoph Tang and colleagues identify a horizontally acquired genetic island encoding peptides that drive autolysis and human cell lysis, suggesting a role in colonization and disease.</p> <p><br></p> </div> </div> <p class="credits">Image credit: pbio.3003001</p><a class="block-image" alt="Horizontally acquired autolysis islands in N. gonorrhoeae" href="https://journals-plos-org.translate.goog/plosbiology/article?id=10.1371/journal.pbio.3003001&_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB"><img alt="Horizontally acquired autolysis islands in N. gonorrhoeae" data-file-extension="jpg" src="/plosbiology/indirect/e39401c83024bd232644d0628e044a3a1ae534c4cb05a0fee9145d150824c8e4"></a> </article> </div> <div class="row three"> <div class="column left"> <article class="block large image" id="cellcat2-1"> <div class="block-content"> <p class="date">02/04/2025</p> <p class="category">Research Article</p> <h2 class="title"><a alt="Seamounts are oases for pelagic predators" href="https://journals-plos-org.translate.goog/plosbiology/article?id=10.1371/journal.pbio.3003016&_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Seamounts are oases for pelagic predators</a></h2> <div class="blurb"> <p>Seamounts have been likened to ‘oases’ of life in the comparative deserts of the open ocean. 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Irene Ojeda-Naharros, Maxence Nachury and co-authors find that MC4R accumulation is prevented through continuous ubiquitin- and β-arrestin-dependent exit from cilia, unless MC4R is inhibited by its agonist AgRP.</p> </div> </div><a class="block-image" alt="MC4R ubiquitination, ciliary exit and body weight" href="https://journals-plos-org.translate.goog/plosbiology/article?id=10.1371/journal.pbio.3003025&_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB"><img alt="MC4R ubiquitination, ciliary exit and body weight" data-file-extension="jpg" src="/plosbiology/indirect/e4ff65de080b01091d7eb7313b879df6c5a417483331b25a1dc707cf0117ed04"></a> <p class="credits">Image credit: pbio.3003025</p> </article> <article class="block large image" id="cellcat2-3"> <div class="block-content"> <p class="date">02/03/2025</p> <p class="category">Research Article</p> <h2 class="title"><a alt="Asymmetry of the trypanosome nuclear pore" href="https://journals-plos-org.translate.goog/plosbiology/article?id=10.1371/journal.pbio.3003024&_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Asymmetry of the trypanosome nuclear pore</a></h2> <div class="blurb"> <p>How transport directionality is achieved through the trypanosome nuclear pore complex is unclear, as the current structural model is mostly symmetrical. Using a combination of expansion microscopy and proximity labeling, Bernardo Papini Gabiatti, Martin Zoltner, Susanne Kramer and colleagues reveal that the trypanosome nuclear pore has an asymmetrical architecture, with conserved hubs that direct mRNA transport.</p> </div> </div><a class="block-image" alt="Asymmetry of the trypanosome nuclear pore" href="https://journals-plos-org.translate.goog/plosbiology/article?id=10.1371/journal.pbio.3003024&_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB"><img alt="Asymmetry of the trypanosome nuclear pore" data-file-extension="jpg" src="/plosbiology/indirect/0477928b58d6340f8a72511c46b064aec85ee85f5a244e0fae4c0fd72845a404"></a> <p class="credits">Image credit: pbio.3003024</p> </article> <div class="row-small-blocks"> <article class="block small image" id="cellcat3-1"> <div class="block-content"> <p class="date">02/07/2025</p> <p class="category">Perspective</p> <h2 class="title"><a alt="Broadening altmetrics" href="https://journals-plos-org.translate.goog/plosbiology/article?id=10.1371/journal.pbio.3003010&_x_tr_sl=pl&_x_tr_tl=ru&_x_tr_hl=en-GB">Broadening altmetrics</a></h2> <div class="blurb"> <p>Common altmetrics indices are limited and biased in the social media that they cover. 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