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Katie Pollard | Gladstone Institutes
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views-field-field-last-name"><div class="field-content"><h1 class="page-title">Katie Pollard, PhD </h1></div></div><div class="views-field views-field-uid"><span class="field-content"><a class="inst1" href="/science/data-science-and-biotechnology-institute">Gladstone Institute of Data Science and Biotechnology</a></span></div></div> </div> <div class="view-footer"> <script> let myElement = document.getElementById("inst3"); if (myElement.classList.contains("inst3")) { var style = document.createElement('style'); style.innerHTML = ` .investigator .system-messages {margin-top: 167px;} @media (max-width: 991px) { .investigator .system-messages { margin-top: 100px; } } `; document.head.appendChild(style); } </script> <style> h1.page-title {text-transform:uppercase} .inst1,.inst2,.inst3 {display:block} .inst2,.inst1 {padding-bottom:4px} @media and (max-width: 600px) { .inst2, .inst3{display:none !important;} } @media (min-width: 768px) and (max-width: 991px) { .path-people-catherine-tcheandjieu-gueliatcha .system-messages {margin-top: 105px !important;} } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix main-content region--dark-typography region--white-background region--no-separator"> <div class="clearfix main-content__container"> <div class="row"> <section> <div class="clearfix main-content__section" > <div class="region region-content"> <div id="block-showcase-lite-content" class="clearfix block block-system block-system-main-block"> <div class="content"> <article class="user user--full"> <div id="subtabs" class="subtabs"> <ul class="sudonav"> <li class="tab"><a href="#research" ><span>Research</span></a></li> <li class="tab"><a href="#about" ><span>About</span></a></li> <li class="tab"><a href="#publications" ><span>Publications</span></a></li> <li class="tab"><a href="#contact" ><span>Contact</span></a></li> <!-- <li id="labbies" class="tab labbies"><a href="#labmembers" ><span>Lab Members</span></a></li> --> </ul> <div class="content-wrap"> <section id="research"> <div class="container"> <div class="clearfix text-formatted field field--name-field-overview field--type-text-long field--label-hidden field__item"><p>Katie Pollard and <a href="http://docpollard.org/" target="_blank">her team</a> develop models that enable them to decode how genomes work, evolve, and break in disease. Their analyses of massive sets of genomic and epigenomic data include investigating human genetic variation, understanding what makes humans unique compared to other species, and characterizing the genomic diversity of the human microbiome, the group of bacteria that populate our digestive system and other body sites. An evolutionary focus, coupled with rigorous statistical methods and bioinformatics tool development, gives the lab a unique perspective on human biology and disease.</p> </div> <div id="dis-tise" class="row"> <div class="col-sm-6"> <h3 class="orange">Disease Areas</h3> <div class="field field--name-field-disease-area field--type-string field--label-hidden field__items"> <div class="field__item">Cancers</div> <div class="field__item">Congenital Heart Defects </div> <div class="field__item">Genetic Diseases</div> <div class="field__item">Infectious Diseases</div> <div class="field__item">Inflammatory Bowel Disease and Other Microbiome-Related Diseases</div> <div class="field__item">Neurodegenerative Diseases</div> <div class="field__item">Psychiatric Diseases</div> </div> </div> <div class="col-sm-6"> <h3 class="orange">Areas of Expertise</h3> <div class="field field--name-field-areas-of-expertise field--type-string field--label-hidden field__items"> <div class="field__item">Bioinformatics </div> <div class="field__item">Data Science</div> <div class="field__item">Developmental Biology</div> <div class="field__item">Epigenetics</div> <div class="field__item">Genome Evolution</div> <div class="field__item">Genomics</div> <div class="field__item">Machine Learning/AI</div> <div class="field__item">Microbiome</div> <div class="field__item">Statistics</div> <div class="field__item">Technology Development</div> </div> </div> </div> </div> <div class="lab-focus"> <div class="focus-img-bk"> <div class="focus-image"> <img src="/sites/default/files/user-pics/gladstone-institute-of-data-science-and-biotechnology.jpg" alt="Working in the Pollard lab" /> </div> </div> <div class="focus-points"> <h3>Lab Focus</h3> <div class="field field--name-field-lab-focus field--type-string-long field--label-hidden field__items"> <div class="field__item">Creating tools for genomic data analysis that combine statistical rigor, an evolutionary perspective, and massive integration of public data. </div> <div class="field__item">Using AI and other predictive computational models to gain a mechanistic understanding of human biology.</div> <div class="field__item">Identifying the genetic basis for human traits and diseases.</div> <div class="field__item">Characterizing the human microbiome through metagenomic data analysis.</div> <div class="field__item">Designing biomedical research technologies to optimize what we can learn from them.</div> <div class="field__item">Science communication and education.</div> </div> </div> </div> <div class="container"> <div class="impact"> <h3>Research Impact</h3> <div class="clearfix text-formatted field field--name-field-research-impact field--type-text-long field--label-hidden field__item"><p>Pollard pioneered a statistical approach to identify the fastest-evolving regions of the human genome, known as Human Accelerated Regions (HARs). Her team showed that many of these correspond to non-coding sequences controlling the expression of genes important for development and associated with psychiatric disorders. The lab also used machine learning to reveal the importance of DNA shape and folding in gene regulation. These studies have generated research tools for studying human disease that are yielding novel therapeutic targets.</p> <p>Pollard has also designed metagenomic-based methods to study the human microbiome at the resolution of individual genes and genetic mutations. From these studies, novel insight will arise into the relationship of the microbiome to health and disease, setting the stage for using metagenomics in precision medicine.</p> <p>The Pollard Lab’s open-source code for gene expression analysis, detecting evolutionary conservation and acceleration, and quantifying genetic changes in the human microbiome is used in thousands of labs and classrooms.</p> </div> </div> </div> <div> </div> <div id="related-news"> <div class="container"> <h2>Related News</h2> <div class="button-right"><a href="/news?categories=Pollard%20lab" class="button outline" tabindex="-1">Read All</a></div> <div id="owl" class="owl-carousel"> </div> </div> </div> </section> <section id="about"> <div class="container"> <div class="prof-titles"> <h3>Professional Titles</h3> <p>L.K. Whittier Director, Gladstone Institute of Data Science and Biotechnology</p> <p>Senior Investigator, Gladstone Institutes</p> <p>Professor, Department of Epidemiology and Biostatistics, UC San Francisco</p> <p>Director, Biomedical Informatics Graduate Program, UC San Francisco</p> <p>Investigator, Chan Zuckerberg Biohub San Francisco</p> </div> <h3>Bio</h3> <div class="clearfix text-formatted field field--name-field-bio field--type-text-long field--label-hidden field__item"><p>Computational biology, which empowers scientists to draw new insights from massive amounts of data, is Katie Pollard’s métier. She earned her PhD in biostatistics at UC Berkeley, then completed a postdoctoral fellowship at UC Santa Cruz, where she worked with David Haussler, the renowned bioinformatician who led the team that assembled the first human genome sequence. During her fellowship, Pollard discovered rapidly evolving regions in the human genome that may help explain the emergence of brain capabilities unique to humans and may also point to their vulnerability to neurological diseases. After serving as an assistant professor at UC Davis, Pollard joined Gladstone in 2008. She was appointed founding director of the Gladstone Institute of Biotechnology and Data Science in 2018.</p> <p>In her work, Pollard designs computer programs that can test a million or more hypothetical experiments in a day to predict outcomes. This approach helps identify and prioritize which research avenues performed in a lab are most likely to lead to success, increasing efficiency and speeding discovery.</p> <p>Her team is recognized for both its rigor to the field of genomics and for its generosity: the open-source software they create is readily shared with scientists around the world. Pollard herself is a dedicated mentor who takes pride in equipping women and other underrepresented groups in science with the skills and training to launch successful careers—and encourages them to extend the practice to the next generation.</p> <p>Pollard also lends her expertise as an advisor to research programs across the country, including those at the Simons Foundation, The Rockefeller University, and Stanford University, and to biotechnology companies such as Phylagen and Tenaya Therapeutics.</p> </div> <div class="why-gladstone"> <h3>What are you most excited about in your lab right now?</h3> <p>“It is such a thrill that we can now rapidly screen trillions of causal hypotheses about genetic diseases using AI models built in our lab This pushes us to take risks and enables us to prioritize the experiments that are most likely to yield new discoveries.”</p> </div> <div class="why-who"> Katie Pollard, PhD </div> <h3>Honors and Awards</h3> <div class="honors-awards"> <p class="item-1 firstWord">2023 Fellow, American Association for the Advancement of Science</p> <p class="item-2 firstWord">2022 Elected member, National Academy of Medicine</p> <p class="item-3 firstWord">2021 Fellow, American Institute for Medical and Biological Engineering</p> <p class="item-4 firstWord">2020 Fellow, International Society for Computational Biology</p> <p class="item-5 firstWord">2018 Named to “San Francisco Business Times’” list of “Women Who Lead in the Life Sciences”</p> <p class="item-6 firstWord">2018 Named to UC Berkeley School of Public Health’s list of “75 Most Influential Alumni”</p> <p class="item-7 firstWord">2017 Named a Chan-Zuckerberg Biohub Investigator</p> <p class="item-8 firstWord">2013 Fellow, California Academy of Sciences</p> <p class="item-9 firstWord">2013 Alumna of the Year, UC Berkeley School of Public Health </p> <p class="item-10 firstWord">2013 Best Scientific Visualizations of the Year, “Wired” Magazine</p> <p class="item-11 firstWord">2009 Breakthrough Biomedical Research Award, UC San Francisco</p> <p class="item-12 firstWord">2008 Sloan Research Fellowship, Alfred P. Sloan Foundation</p> <p class="item-13 firstWord">2007 Faculty Development Award, UC Davis</p> <p class="item-14 firstWord">2003 Evelyn Fix Memorial Prize, Chin Long Chiang Biostatistics Student of the Year, UC Berkeley</p> <p class="item-15 firstWord">1998 Berkeley Fellowship, UC Berkeley</p> <p class="item-16 firstWord">1996 Thomas J. Watson Fellowship, Watson Foundation</p> <p class="item-17 firstWord">1995 Valedictorian, High Scholarship Prize, Math Prize, Anthropology Prize, Phi Beta Kappa Award, Pomona College</p> <p class="item-18 firstWord">1993 Sophomore Math Prize, Pomona College</p> <div class="cntrbutt"><a class="moreawards button outline">See More</a></div> </div> </div> </section> <section id="publications"> <div class="container"> <h3>Publications</h3> <div id="profiles_publications"></div> </div> <div class="container"> <p class="cntrbutt"><a class="morepub button outline">More Publications</a></p> </div> </section> <section id="contact"> <div class="container"> <h3> Contact</h3> <div class="row"> <div class="col-sm-7"> <p class="to-hide"><b>Katie Pollard</b><br> <a href="mailto:katie.pollard@gladstone.ucsf.edu">Email</a><br> <a href="tel:415.734.2711" title="Call" class="ph-link inv-phone">415.734.2711</a></p> <div class="investigator-assistants"> <article class="user user--compact"> <div class="user__compact"> <p> <b>Marian Perez</b><br>Administrative Specialist<br> <a href="tel:415.734.2743" title="Call" class="ph-link">415.734.2743</a><br> <a href="mailto:marian.perez@gladstone.ucsf.edu">Email</a> </p> </div> </article> <br> <article class="user user--compact"> <div class="user__compact"> <p> <b>Zainab Yusuf-Sada</b><br>Senior Executive Administrator<br> <a href="tel:415.734.4827" title="Call" class="ph-link">415.734.4827</a><br> <a href="mailto:zainab.yusufsada@gladstone.ucsf.edu">Email</a> </p> </div> </article> <br> </div> </div> <div class="col-sm-5" > <p class="labsite"> <a href="http://docpollard.org/" class="button magenta" target="_blank">Pollard Lab Website</a> </p> <table class="relatedlinks"><tr> <link rel="stylesheet" href="/themes/custom/showcase_lite/css/theme/academicons/css/academicons.min.css"> </table> </div> </div> </div> </section> <section id="labmembers"> <div class="container"> <div class="prof-titles"> <h3>Lab Members</h3> </div> <div class="row"> <div class="item"><div class="blowpic">Abe Arab<br><div class="lmtitle">Rotation Student</div><div class="la-mail"><script>user = "Abe.Arab";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Cindy Barrios<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Cindy.Barrios";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Zoe Chen, MS <br><div class="lmtitle">Rotation Student</div><div class="la-mail"><script>user = "Zoe.Chen";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Shiron Drusinsky<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Shiron.Drusinsky";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Veronika Dubinkina, PhD <br><div class="lmtitle">Bioinformatics Fellow</div><div class="la-mail"><script>user = "Veronika.Dubinkina";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Amanda Everitt<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Amanda.Everitt";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Sandy Floren<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Sandy.Floren";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Katie Gjoni<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Katie.Gjoni";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Miriam Goldman<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Miriam.Goldman";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Zhirui Hu, PhD <br><div class="lmtitle">Bioinformatics Fellow</div><div class="la-mail"><script>user = "Zhirui.Hu";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Xiaofan Jin, PhD <br><div class="lmtitle">Collaborator</div><div class="la-mail"><script>user = "Xiaofan.Jin";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Ryan Keivanfar<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Ryan.Keivanfar";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Shuzhen Kuang, PhD <br><div class="lmtitle">Bioinformatics Fellow</div><div class="la-mail"><script>user = "Shuzhen.Kuang";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Jodi Lee<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Jodi.Lee";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Abigail Lind, PhD <br><div class="lmtitle">Collaborator</div><div class="la-mail"><script>user = "Abigail.Lind";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Megan Ostrowski<br><div class="lmtitle">Affiliate</div><div class="la-mail"><script>user = "Megan.Ostrowski";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Cindy Pino<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Cindy.Pino";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Maureen Pittman<br><div class="lmtitle">Collaborator</div><div class="la-mail"><script>user = "Maureen.Pittman";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Byron Smith, PhD <br><div class="lmtitle">Bioinformatics Fellow</div><div class="la-mail"><script>user = "Byron.Smith";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Sean Whalen, PhD <br><div class="lmtitle">Senior Staff Research Scientist</div><div class="la-mail"><script>user = "Sean.Whalen";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Shu Zhang<br><div class="lmtitle">Graduate Student</div><div class="la-mail"><script>user = "Shu.Zhang";site = "gladstone.ucsf.edu";document.write('<a href="mailto:' + user + '@' + site + '">Email</a>');</SCRIPT> </div></div></div><div class="item"><div class="blowpic">Xinru Zhang<br><div 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