Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study

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Ulnar CMAP, EIM, blood SMN mRNA levels, and serum protein analytes were able to distinguish between cohorts at the enrollment visit."><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/ed1a5a1f-b279-475e-88e3-75f261729818/core/no-script.css"> </noscript> <meta name="citation_title" content="Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study"> <meta name="citation_authors" content="Kolb SJ;Coffey CS;Yankey JW;Krosschell K;Arnold WD;Rutkove SB;Swoboda KJ;Reyna SP;Sakonju A;Darras BT;Shell R;Kuntz N;Castro D;Iannaccone ST;Parsons J;Connolly AM;Chiriboga CA;McDonald C;Burnette WB;Werner K;Thangarajh M;Shieh PB;Finanger E;Cudkowicz ME;McGovern MM;McNeil DE;Finkel R;Kaye E;Kingsley A;Renusch SR;McGovern VL;Wang X;Zaworski PG;Prior TW;Burghes AH;Bartlett A;Kissel JT; ;"> <meta name="citation_date" content="01/21/2016"> <meta name="citation_publisher" content="Ann Clin Transl Neurol"> <meta name="citation_journal_title" content="Annals of clinical and translational neurology"> <meta name="citation_pmid" content="26900585"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/26900585/"> <meta name="citation_volume" content="3"> <meta name="citation_issue" content="2"> <meta name="citation_doi" content="10.1002/acn3.283"> <meta name="citation_issn" content="2328-9503"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/26900585/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="C5vmH6aQUwtWZiIGYtbKO7sqMRcVyZsXYXVUVb4CSqHzQJvNGmXC8Oc2BiCn9i8D"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="C5vmH6aQUwtWZiIGYtbKO7sqMRcVyZsXYXVUVb4CSqHzQJvNGmXC8Oc2BiCn9i8D"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="C5vmH6aQUwtWZiIGYtbKO7sqMRcVyZsXYXVUVb4CSqHzQJvNGmXC8Oc2BiCn9i8D"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="C5vmH6aQUwtWZiIGYtbKO7sqMRcVyZsXYXVUVb4CSqHzQJvNGmXC8Oc2BiCn9i8D"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> 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collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 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class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Annals of clinical and translational neurology" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Annals of clinical and translational neurology" data-pinger-ignore> Ann Clin Transl Neurol </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Annals of clinical and translational neurology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Ann+Clin+Transl+Neurol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Ann+Clin+Transl+Neurol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Ann Clin Transl Neurol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Ann Clin Transl Neurol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Ann+Clin+Transl+Neurol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Ann Clin Transl Neurol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Ann Clin Transl Neurol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Ann Clin Transl Neurol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2016 Jan 21;3(2):132-45.</span> </div> <span class="citation-doi"> doi: 10.1002/acn3.283. </span> <span class="secondary-date"> eCollection 2016 Feb. </span> </div> <h1 class="heading-title"> Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Kolb+SJ&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Stephen J Kolb">Stephen J Kolb</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Coffey+CS&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christopher S Coffey">Christopher S Coffey</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biostatistics Neuro NEXT Data Coordinating Center University of Iowa Iowa City Iowa." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yankey+JW&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jon W Yankey">Jon W Yankey</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biostatistics Neuro NEXT Data Coordinating Center University of Iowa Iowa City Iowa." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Krosschell+K&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kristin Krosschell">Kristin Krosschell</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Physical Therapy and Human Movement Sciences and Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Arnold+WD&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="W David Arnold">W David Arnold</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Physical Medicine and Rehabilitation The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rutkove+SB&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Seward B Rutkove">Seward B Rutkove</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Beth Israel Deaconess Medical Center Boston Massachusetts." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Swoboda+KJ&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kathryn J Swoboda">Kathryn J Swoboda</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah; Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#full-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Reyna+SP&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sandra P Reyna">Sandra P Reyna</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah; Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#full-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sakonju+A&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ai Sakonju">Ai Sakonju</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah." href="#full-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Darras+BT&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Basil T Darras">Basil T Darras</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Boston Children's Hospital Boston Massachusetts." href="#full-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shell+R&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Richard Shell">Richard Shell</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Nationwide Children's Hospital Columbus Ohio." href="#full-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kuntz+N&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nancy Kuntz">Nancy Kuntz</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois." href="#full-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Castro+D&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Diana Castro">Diana Castro</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="UT Southwestern Medical Center Dallas Texas." href="#full-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Iannaccone+ST&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Susan T Iannaccone">Susan T Iannaccone</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="UT Southwestern Medical Center Dallas Texas." href="#full-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Parsons+J&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Julie Parsons">Julie Parsons</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Children's Hospital Colorado, University of Colorado School of Medicine Aurora Colorado." href="#full-view-affiliation-12" ref="linksrc=author_aff"> 12 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Connolly+AM&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Anne M Connolly">Anne M Connolly</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Washington University School of Medicine in St. Louis St. Louis Missouri." href="#full-view-affiliation-13" ref="linksrc=author_aff"> 13 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chiriboga+CA&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Claudia A Chiriboga">Claudia A Chiriboga</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Columbia College of Physicians and Surgeons New York New York." href="#full-view-affiliation-14" ref="linksrc=author_aff"> 14 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McDonald+C&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Craig McDonald">Craig McDonald</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University of California - Davis Davis California." href="#full-view-affiliation-15" ref="linksrc=author_aff"> 15 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Burnette+WB&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="W Bryan Burnette">W Bryan Burnette</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Vanderbilt University Nashville Tennessee." href="#full-view-affiliation-16" ref="linksrc=author_aff"> 16 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Werner+K&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Klaus Werner">Klaus Werner</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="SUNY Upstate Medical Center Syracuse New York." href="#full-view-affiliation-17" ref="linksrc=author_aff"> 17 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Thangarajh+M&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mathula Thangarajh">Mathula Thangarajh</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Children's National Medical Center Washington District of Columbia." href="#full-view-affiliation-18" ref="linksrc=author_aff"> 18 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shieh+PB&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Perry B Shieh">Perry B Shieh</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University of California - Los Angeles Los Angeles California." href="#full-view-affiliation-19" ref="linksrc=author_aff"> 19 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Finanger+E&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Erika Finanger">Erika Finanger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dorenbecher Children's Hospital Portland Oregon." href="#full-view-affiliation-20" ref="linksrc=author_aff"> 20 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cudkowicz+ME&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Merit E Cudkowicz">Merit E Cudkowicz</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#full-view-affiliation-21" ref="linksrc=author_aff"> 21 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McGovern+MM&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michelle M McGovern">Michelle M McGovern</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#full-view-affiliation-21" ref="linksrc=author_aff"> 21 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McNeil+DE&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="D Elizabeth McNeil">D Elizabeth McNeil</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Institute of Neurological Disorders and Stroke Bethesda Maryland." href="#full-view-affiliation-22" ref="linksrc=author_aff"> 22 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Finkel+R&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Richard Finkel">Richard Finkel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Nemours Children's Hospital Orlando Florida." href="#full-view-affiliation-23" ref="linksrc=author_aff"> 23 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kaye+E&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Edward Kaye">Edward Kaye</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sarepta Therapeutics Cambridge Massachusetts." href="#full-view-affiliation-24" ref="linksrc=author_aff"> 24 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kingsley+A&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Allison Kingsley">Allison Kingsley</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-25" ref="linksrc=author_aff"> 25 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Renusch+SR&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Samantha R Renusch">Samantha R Renusch</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McGovern+VL&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Vicki L McGovern">Vicki L McGovern</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+X&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xueqian Wang">Xueqian Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zaworski+PG&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Phillip G Zaworski">Phillip G Zaworski</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharm Optima Portage Michigan." href="#full-view-affiliation-27" ref="linksrc=author_aff"> 27 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Prior+TW&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thomas W Prior">Thomas W Prior</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Molecular Pathology Ohio State Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-28" ref="linksrc=author_aff"> 28 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Burghes+AH&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Arthur H M Burghes">Arthur H M Burghes</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bartlett+A&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Amy Bartlett">Amy Bartlett</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-25" ref="linksrc=author_aff"> 25 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kissel+JT&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John T Kissel">John T Kissel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio." href="#full-view-affiliation-25" ref="linksrc=author_aff"> 25 </a></sup><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name" href="/?term=NeuroNEXT+Clinical+Trial+Network+and+on+behalf+of+the+NN101+SMA+Biomarker+Investigators%5BCorporate+Author%5D" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators">NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/26900585/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> Department of Biostatistics Neuro NEXT Data Coordinating Center University of Iowa Iowa City Iowa.</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> Departments of Physical Therapy and Human Movement Sciences and Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Physical Medicine and Rehabilitation The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="full-view-affiliation-5" id="full-view-affiliation-5" ><sup class="key">5</sup> Department of Neurology Beth Israel Deaconess Medical Center Boston Massachusetts.</li> <li data-affiliation-id="full-view-affiliation-6" id="full-view-affiliation-6" ><sup class="key">6</sup> Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah; Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts.</li> <li data-affiliation-id="full-view-affiliation-7" id="full-view-affiliation-7" ><sup class="key">7</sup> Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah.</li> <li data-affiliation-id="full-view-affiliation-8" id="full-view-affiliation-8" ><sup class="key">8</sup> Department of Neurology Boston Children's Hospital Boston Massachusetts.</li> <li data-affiliation-id="full-view-affiliation-9" id="full-view-affiliation-9" ><sup class="key">9</sup> Nationwide Children's Hospital Columbus Ohio.</li> <li data-affiliation-id="full-view-affiliation-10" id="full-view-affiliation-10" ><sup class="key">10</sup> Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois.</li> <li data-affiliation-id="full-view-affiliation-11" id="full-view-affiliation-11" ><sup class="key">11</sup> UT Southwestern Medical Center Dallas Texas.</li> <li data-affiliation-id="full-view-affiliation-12" id="full-view-affiliation-12" ><sup class="key">12</sup> Children's Hospital Colorado, University of Colorado School of Medicine Aurora Colorado.</li> <li data-affiliation-id="full-view-affiliation-13" id="full-view-affiliation-13" ><sup class="key">13</sup> Washington University School of Medicine in St. Louis St. Louis Missouri.</li> <li data-affiliation-id="full-view-affiliation-14" id="full-view-affiliation-14" ><sup class="key">14</sup> Department of Neurology Columbia College of Physicians and Surgeons New York New York.</li> <li data-affiliation-id="full-view-affiliation-15" id="full-view-affiliation-15" ><sup class="key">15</sup> University of California - Davis Davis California.</li> <li data-affiliation-id="full-view-affiliation-16" id="full-view-affiliation-16" ><sup class="key">16</sup> Vanderbilt University Nashville Tennessee.</li> <li data-affiliation-id="full-view-affiliation-17" id="full-view-affiliation-17" ><sup class="key">17</sup> SUNY Upstate Medical Center Syracuse New York.</li> <li data-affiliation-id="full-view-affiliation-18" id="full-view-affiliation-18" ><sup class="key">18</sup> Children's National Medical Center Washington District of Columbia.</li> <li data-affiliation-id="full-view-affiliation-19" id="full-view-affiliation-19" ><sup class="key">19</sup> University of California - Los Angeles Los Angeles California.</li> <li data-affiliation-id="full-view-affiliation-20" id="full-view-affiliation-20" ><sup class="key">20</sup> Dorenbecher Children's Hospital Portland Oregon.</li> <li data-affiliation-id="full-view-affiliation-21" id="full-view-affiliation-21" ><sup class="key">21</sup> Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts.</li> <li data-affiliation-id="full-view-affiliation-22" id="full-view-affiliation-22" ><sup class="key">22</sup> National Institute of Neurological Disorders and Stroke Bethesda Maryland.</li> <li data-affiliation-id="full-view-affiliation-23" id="full-view-affiliation-23" ><sup class="key">23</sup> Nemours Children's Hospital Orlando Florida.</li> <li data-affiliation-id="full-view-affiliation-24" id="full-view-affiliation-24" ><sup class="key">24</sup> Sarepta Therapeutics Cambridge Massachusetts.</li> <li data-affiliation-id="full-view-affiliation-25" id="full-view-affiliation-25" ><sup class="key">25</sup> Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="full-view-affiliation-26" id="full-view-affiliation-26" ><sup class="key">26</sup> Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="full-view-affiliation-27" id="full-view-affiliation-27" ><sup class="key">27</sup> Pharm Optima Portage Michigan.</li> <li data-affiliation-id="full-view-affiliation-28" id="full-view-affiliation-28" ><sup class="key">28</sup> Department of Molecular Pathology Ohio State Wexner Medical Center Columbus Ohio.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">26900585</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC4748311&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4748311/" data-ga-category="full_text" data-ga-action="PMCID" > PMC4748311 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1002/acn3.283&id_type=DOI" href="https://doi.org/10.1002/acn3.283" data-ga-category="full_text" data-ga-action="DOI" > 10.1002/acn3.283 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Stephen J Kolb</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Ann Clin Transl Neurol<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2016">2016</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button 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</a></li></ul></div></div></div><span class="period">. </span><span class="cit">2016 Jan 21;3(2):132-45.</span> </div> <span class="citation-doi"> doi: 10.1002/acn3.283. </span> <span class="secondary-date"> eCollection 2016 Feb. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Kolb+SJ&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Stephen J Kolb">Stephen J Kolb</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Coffey+CS&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christopher S Coffey">Christopher S Coffey</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biostatistics Neuro NEXT Data Coordinating Center University of Iowa Iowa City Iowa." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Yankey+JW&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jon W Yankey">Jon W Yankey</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biostatistics Neuro NEXT Data Coordinating Center University of Iowa Iowa City Iowa." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Krosschell+K&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kristin Krosschell">Kristin Krosschell</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Physical Therapy and Human Movement Sciences and Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Arnold+WD&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="W David Arnold">W David Arnold</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Physical Medicine and Rehabilitation The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rutkove+SB&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Seward B Rutkove">Seward B Rutkove</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Beth Israel Deaconess Medical Center Boston Massachusetts." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Swoboda+KJ&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Kathryn J Swoboda">Kathryn J Swoboda</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah; Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Reyna+SP&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sandra P Reyna">Sandra P Reyna</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah; Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sakonju+A&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ai Sakonju">Ai Sakonju</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah." href="#short-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Darras+BT&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Basil T Darras">Basil T Darras</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Boston Children's Hospital Boston Massachusetts." href="#short-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shell+R&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Richard Shell">Richard Shell</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Nationwide Children's Hospital Columbus Ohio." href="#short-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kuntz+N&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nancy Kuntz">Nancy Kuntz</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois." href="#short-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Castro+D&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Diana Castro">Diana Castro</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="UT Southwestern Medical Center Dallas Texas." href="#short-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Iannaccone+ST&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Susan T Iannaccone">Susan T Iannaccone</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="UT Southwestern Medical Center Dallas Texas." href="#short-view-affiliation-11" ref="linksrc=author_aff"> 11 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Parsons+J&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Julie Parsons">Julie Parsons</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Children's Hospital Colorado, University of Colorado School of Medicine Aurora Colorado." href="#short-view-affiliation-12" ref="linksrc=author_aff"> 12 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Connolly+AM&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Anne M Connolly">Anne M Connolly</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Washington University School of Medicine in St. Louis St. Louis Missouri." href="#short-view-affiliation-13" ref="linksrc=author_aff"> 13 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chiriboga+CA&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Claudia A Chiriboga">Claudia A Chiriboga</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Columbia College of Physicians and Surgeons New York New York." href="#short-view-affiliation-14" ref="linksrc=author_aff"> 14 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McDonald+C&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Craig McDonald">Craig McDonald</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University of California - Davis Davis California." href="#short-view-affiliation-15" ref="linksrc=author_aff"> 15 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Burnette+WB&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="W Bryan Burnette">W Bryan Burnette</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Vanderbilt University Nashville Tennessee." href="#short-view-affiliation-16" ref="linksrc=author_aff"> 16 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Werner+K&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Klaus Werner">Klaus Werner</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="SUNY Upstate Medical Center Syracuse New York." href="#short-view-affiliation-17" ref="linksrc=author_aff"> 17 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Thangarajh+M&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mathula Thangarajh">Mathula Thangarajh</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Children's National Medical Center Washington District of Columbia." href="#short-view-affiliation-18" ref="linksrc=author_aff"> 18 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shieh+PB&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Perry B Shieh">Perry B Shieh</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University of California - Los Angeles Los Angeles California." href="#short-view-affiliation-19" ref="linksrc=author_aff"> 19 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Finanger+E&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Erika Finanger">Erika Finanger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dorenbecher Children's Hospital Portland Oregon." href="#short-view-affiliation-20" ref="linksrc=author_aff"> 20 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Cudkowicz+ME&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Merit E Cudkowicz">Merit E Cudkowicz</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#short-view-affiliation-21" ref="linksrc=author_aff"> 21 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McGovern+MM&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michelle M McGovern">Michelle M McGovern</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts." href="#short-view-affiliation-21" ref="linksrc=author_aff"> 21 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McNeil+DE&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="D Elizabeth McNeil">D Elizabeth McNeil</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="National Institute of Neurological Disorders and Stroke Bethesda Maryland." href="#short-view-affiliation-22" ref="linksrc=author_aff"> 22 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Finkel+R&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Richard Finkel">Richard Finkel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Nemours Children's Hospital Orlando Florida." href="#short-view-affiliation-23" ref="linksrc=author_aff"> 23 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kaye+E&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Edward Kaye">Edward Kaye</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Sarepta Therapeutics Cambridge Massachusetts." href="#short-view-affiliation-24" ref="linksrc=author_aff"> 24 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kingsley+A&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Allison Kingsley">Allison Kingsley</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-25" ref="linksrc=author_aff"> 25 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Renusch+SR&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Samantha R Renusch">Samantha R Renusch</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McGovern+VL&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Vicki L McGovern">Vicki L McGovern</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+X&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Xueqian Wang">Xueqian Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zaworski+PG&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Phillip G Zaworski">Phillip G Zaworski</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharm Optima Portage Michigan." href="#short-view-affiliation-27" ref="linksrc=author_aff"> 27 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Prior+TW&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Thomas W Prior">Thomas W Prior</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Molecular Pathology Ohio State Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-28" ref="linksrc=author_aff"> 28 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Burghes+AH&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Arthur H M Burghes">Arthur H M Burghes</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-26" ref="linksrc=author_aff"> 26 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bartlett+A&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Amy Bartlett">Amy Bartlett</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-25" ref="linksrc=author_aff"> 25 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kissel+JT&cauthor_id=26900585" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John T Kissel">John T Kissel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio." href="#short-view-affiliation-25" ref="linksrc=author_aff"> 25 </a></sup><span class="semicolon">; </span></span><span class="authors-list-item "><a class="full-name" href="/?term=NeuroNEXT+Clinical+Trial+Network+and+on+behalf+of+the+NN101+SMA+Biomarker+Investigators%5BCorporate+Author%5D" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators">NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Department of Biostatistics Neuro NEXT Data Coordinating Center University of Iowa Iowa City Iowa.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Departments of Physical Therapy and Human Movement Sciences and Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio; Department of Physical Medicine and Rehabilitation The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="short-view-affiliation-5" id="short-view-affiliation-5" ><sup class="key">5</sup> Department of Neurology Beth Israel Deaconess Medical Center Boston Massachusetts.</li> <li data-affiliation-id="short-view-affiliation-6" id="short-view-affiliation-6" ><sup class="key">6</sup> Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah; Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts.</li> <li data-affiliation-id="short-view-affiliation-7" id="short-view-affiliation-7" ><sup class="key">7</sup> Departments of Neurology and Pediatrics University of Utah Salt Lake City Utah.</li> <li data-affiliation-id="short-view-affiliation-8" id="short-view-affiliation-8" ><sup class="key">8</sup> Department of Neurology Boston Children's Hospital Boston Massachusetts.</li> <li data-affiliation-id="short-view-affiliation-9" id="short-view-affiliation-9" ><sup class="key">9</sup> Nationwide Children's Hospital Columbus Ohio.</li> <li data-affiliation-id="short-view-affiliation-10" id="short-view-affiliation-10" ><sup class="key">10</sup> Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois.</li> <li data-affiliation-id="short-view-affiliation-11" id="short-view-affiliation-11" ><sup class="key">11</sup> UT Southwestern Medical Center Dallas Texas.</li> <li data-affiliation-id="short-view-affiliation-12" id="short-view-affiliation-12" ><sup class="key">12</sup> Children's Hospital Colorado, University of Colorado School of Medicine Aurora Colorado.</li> <li data-affiliation-id="short-view-affiliation-13" id="short-view-affiliation-13" ><sup class="key">13</sup> Washington University School of Medicine in St. Louis St. Louis Missouri.</li> <li data-affiliation-id="short-view-affiliation-14" id="short-view-affiliation-14" ><sup class="key">14</sup> Department of Neurology Columbia College of Physicians and Surgeons New York New York.</li> <li data-affiliation-id="short-view-affiliation-15" id="short-view-affiliation-15" ><sup class="key">15</sup> University of California - Davis Davis California.</li> <li data-affiliation-id="short-view-affiliation-16" id="short-view-affiliation-16" ><sup class="key">16</sup> Vanderbilt University Nashville Tennessee.</li> <li data-affiliation-id="short-view-affiliation-17" id="short-view-affiliation-17" ><sup class="key">17</sup> SUNY Upstate Medical Center Syracuse New York.</li> <li data-affiliation-id="short-view-affiliation-18" id="short-view-affiliation-18" ><sup class="key">18</sup> Children's National Medical Center Washington District of Columbia.</li> <li data-affiliation-id="short-view-affiliation-19" id="short-view-affiliation-19" ><sup class="key">19</sup> University of California - Los Angeles Los Angeles California.</li> <li data-affiliation-id="short-view-affiliation-20" id="short-view-affiliation-20" ><sup class="key">20</sup> Dorenbecher Children's Hospital Portland Oregon.</li> <li data-affiliation-id="short-view-affiliation-21" id="short-view-affiliation-21" ><sup class="key">21</sup> Department of Neurology Neuro NEXT Clinical Coordinating Center Massachusetts General Hospital Boston Massachusetts.</li> <li data-affiliation-id="short-view-affiliation-22" id="short-view-affiliation-22" ><sup class="key">22</sup> National Institute of Neurological Disorders and Stroke Bethesda Maryland.</li> <li data-affiliation-id="short-view-affiliation-23" id="short-view-affiliation-23" ><sup class="key">23</sup> Nemours Children's Hospital Orlando Florida.</li> <li data-affiliation-id="short-view-affiliation-24" id="short-view-affiliation-24" ><sup class="key">24</sup> Sarepta Therapeutics Cambridge Massachusetts.</li> <li data-affiliation-id="short-view-affiliation-25" id="short-view-affiliation-25" ><sup class="key">25</sup> Department of Neurology The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="short-view-affiliation-26" id="short-view-affiliation-26" ><sup class="key">26</sup> Department of Biological Chemistry & Pharmacology The Ohio State University Wexner Medical Center Columbus Ohio.</li> <li data-affiliation-id="short-view-affiliation-27" id="short-view-affiliation-27" ><sup class="key">27</sup> Pharm Optima Portage Michigan.</li> <li data-affiliation-id="short-view-affiliation-28" id="short-view-affiliation-28" ><sup class="key">28</sup> Department of Molecular Pathology Ohio State Wexner Medical Center Columbus Ohio.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">26900585</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC4748311&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4748311/" data-ga-category="full_text" data-ga-action="PMCID" > PMC4748311 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1002/acn3.283&id_type=DOI" href="https://doi.org/10.1002/acn3.283" data-ga-category="full_text" data-ga-action="DOI" > 10.1002/acn3.283 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/26900585/citations/" data-citation-style="nlm" data-pubmed-format-link="/26900585/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> <strong class="sub-title"> Objective: </strong> This study prospectively assessed putative promising biomarkers for use in assessing infants with spinal muscular atrophy (SMA). </p> <p> <strong class="sub-title"> Methods: </strong> This prospective, multi-center natural history study targeted the enrollment of SMA infants and healthy control infants less than 6 months of age. Recruitment occurred at 14 centers within the NINDS National Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) Network. Infant motor function scales and putative electrophysiological, protein and molecular biomarkers were assessed at baseline and subsequent visits. </p> <p> <strong class="sub-title"> Results: </strong> Enrollment began November, 2012 and ended September, 2014 with 26 SMA infants and 27 healthy infants enrolled. Baseline demographic characteristics of the SMA and control infant cohorts aligned well. Motor function as assessed by the Test for Infant Motor Performance Items (TIMPSI) and the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) revealed significant differences between the SMA and control infants at baseline. Ulnar compound muscle action potential amplitude (CMAP) in SMA infants (1.4 ± 2.2 mV) was significantly reduced compared to controls (5.5 ± 2.0 mV). Electrical impedance myography (EIM) high-frequency reactance slope (Ohms/MHz) was significantly higher in SMA infants than controls SMA infants had lower survival motor neuron (SMN) mRNA levels in blood than controls, and several serum protein analytes were altered between cohorts. </p> <p> <strong class="sub-title"> Interpretation: </strong> By the time infants were recruited and presented for the baseline visit, SMA infants had reduced motor function compared to controls. Ulnar CMAP, EIM, blood SMN mRNA levels, and serum protein analytes were able to distinguish between cohorts at the enrollment visit. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcb/4748311/c0af2972bc7c/ACN3-3-132-g001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="709" data-image-height="932" data-image-alt="Figure 1" data-pmc-id="PMC4748311" data-figure-id="acn3283-fig-0001"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcb/4748311/d4c0c815abc8/ACN3-3-132-g001.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="709"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="932"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Motor function assessments in <styled-content style="fixed-case"> SMA… </styled-content> </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Motor function assessments in <styled-content style="fixed-case"> SMA </styled-content> and healthy infants in the first 6 months… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1 </strong> <div class="figure-caption-contents">Motor function assessments in <styled-content style="fixed-case">SMA</styled-content> and healthy infants in the first 6 months of life. (A) Motor function testing paradigm. All infants were tested using the <styled-content style="fixed-case">TIMPSI</styled-content>. After the <styled-content style="fixed-case">TIMPSI</styled-content>, a mandatory rest period of 20 minutes was followed by either the <styled-content style="fixed-case">CHOP</styled-content>‐<styled-content style="fixed-case">INTEND</styled-content> or <styled-content style="fixed-case">AIMS</styled-content> assessment. Infants who scored less than 41 on the <styled-content style="fixed-case">TIMPSI</styled-content> were tested using the <styled-content style="fixed-case">CHOP</styled-content>‐<styled-content style="fixed-case">INTEND</styled-content>, otherwise the infant was tested using the <styled-content style="fixed-case">AIMS</styled-content> test. (B) Results of infant motor function tests for all infants as a function of the age at the time of enrollment visit. For the <styled-content style="fixed-case">SMA</styled-content> cohort, the <i><styled-content style="fixed-case">SMN</styled-content>2</i> copy number for each infant is indicated by the color as indicated in the key by each graph. For the healthy cohort the <i><styled-content style="fixed-case">SMN</styled-content>1</i> copy number for each infant is indicated by the color as indicated in the key by each graph.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcb/4748311/3a032e5590d9/ACN3-3-132-g002.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="709" data-image-height="299" data-image-alt="Figure 2" data-pmc-id="PMC4748311" data-figure-id="acn3283-fig-0002"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcb/4748311/477c85594f2b/ACN3-3-132-g002.gif" alt="Figure 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="709"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="299"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Ulnar compound muscle action potential… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Ulnar compound muscle action potential is significantly reduced in <styled-content style="fixed-case"> SMA </styled-content> infants compared to… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2 </strong> <div class="figure-caption-contents">Ulnar compound muscle action potential is significantly reduced in <styled-content style="fixed-case">SMA</styled-content> infants compared to healthy infants. Ulnar <styled-content style="fixed-case">CMAP</styled-content> peak amplitude (<styled-content style="fixed-case">mV</styled-content>) in <styled-content style="fixed-case">SMA</styled-content> and healthy control infants as a function of the age at the time of enrollment visit. For the <styled-content style="fixed-case">SMA</styled-content> cohort, the <i><styled-content style="fixed-case">SMN</styled-content>2</i> copy number for each infant is indicated by the color as indicated in the key by each graph. For the healthy cohort, the <i><styled-content style="fixed-case">SMN</styled-content>1</i> copy number for each infant is indicated by the color as indicated in the key by each graph.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcb/4748311/572859fc1e41/ACN3-3-132-g003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="709" data-image-height="700" data-image-alt="Figure 3" data-pmc-id="PMC4748311" data-figure-id="acn3283-fig-0003"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dcb/4748311/d8f5a02b06a0/ACN3-3-132-g003.gif" alt="Figure 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="709"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="700"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Peripheral blood <styled-content style="fixed-case"> SMN mRNA </styled-content> and… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Peripheral blood <styled-content style="fixed-case"> SMN mRNA </styled-content> and protein levels in <styled-content style="fixed-case"> SMA </styled-content> and healthy control infants.… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3 </strong> <div class="figure-caption-contents">Peripheral blood <styled-content style="fixed-case">SMN mRNA</styled-content> and protein levels in <styled-content style="fixed-case">SMA</styled-content> and healthy control infants. (A) Full‐length <styled-content style="fixed-case">SMN mRNA</styled-content> levels from whole blood measured using dd<styled-content style="fixed-case">PCR</styled-content> expressed as a ratio of <styled-content style="fixed-case">SMN</styled-content> to <styled-content style="fixed-case">HPRT</styled-content>. (B) <styled-content style="fixed-case">SMN</styled-content> protein levels detected in <styled-content style="fixed-case">PBMC</styled-content>s measured by <styled-content style="fixed-case">SMN</styled-content>‐<styled-content style="fixed-case">ECL ELISA</styled-content> expressed as pg/10<sup>7</sup> cells. For the <styled-content style="fixed-case">SMA</styled-content> cohort, the <i><styled-content style="fixed-case">SMN</styled-content>2</i> copy number for each infant is indicated by the color as indicated in the key by each graph. For the healthy cohort, the <i><styled-content style="fixed-case">SMN</styled-content>1</i> copy number for each infant is indicated by the color as indicated in the key by each graph.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/29149772/" ref="article_id=29149772&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="29149772" data-ga-label=""> Natural history of infantile-onset spinal muscular atrophy. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Iannaccone ST, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AHM, Bartlett A, Kissel JT; NeuroNEXT Clinical Trial Network on behalf of the NN101 SMA Biomarker Investigators.</span> <span class="docsum-authors short-authors">Kolb SJ, et al.</span> <span class="docsum-journal-citation full-journal-citation">Ann Neurol. 2017 Dec;82(6):883-891. doi: 10.1002/ana.25101. 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Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study - PubMed