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Mapping the Brain: From Cells and Circuits to Function

<html lang="en"> <head> <!-- CookiePro Cookies Consent Notice start for neuronline.sfn.org --> <script type="text/javascript" src="https://cookie-cdn.cookiepro.com/consent/"760f75b9-29b1-4959-abf2-900a95e073e4"/OtAutoBlock.js"></script> <script src="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="760f75b9-29b1-4959-abf2-900a95e073e4"></script> <script type="text/javascript"> function OptanonWrapper() { } </script> <!-- CookiePro Cookies Consent Notice end for neuronline.sfn.org --> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1"> <link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Roboto:300,400,700|Open+Sans:400,700"> <title>Mapping the Brain: From Cells and Circuits to Function</title> <meta name="pageID" content="fa819410-0e82-445a-a9cc-9ee979b731c9&fo=fa819410-0e82-445a-a9cc-9ee979b731c9"> <meta name="description" content="&lt;p&gt;This lecture from Rui Costa, DVM, PhD, discusses the Allen Institute&#39;s foundational efforts to map diverse cell types and circuits in the mammalian brain using approaches such as single-cell and spatial transcriptomics, morphological and physiological analyses, and advanced light and electron microscopy. &lt;/p&gt;" /> <meta name="search_importance" content="Normal"> <meta name="search_exclude" content="false"> <meta property="og:url" content="https://neuronline.sfn.org/scientific-research/mapping-the-brain-from-cells-and-circuits-to-function" /> <meta property="og:title" content="Mapping the Brain: From Cells and Circuits to Function" /> <meta property="og:description" content="&lt;p&gt;This lecture from Rui Costa, DVM, PhD, discusses the Allen Institute&#39;s foundational efforts to map diverse cell types and circuits in the mammalian brain using approaches such as single-cell and spatial transcriptomics, morphological and physiological analyses, and advanced light and electron microscopy. &lt;/p&gt;" /> <meta property="og:image" content="https://neuronline.sfn.org/-/media/Project/Neuronline/Article-Images/Scientific-Research/2024/PSL/20241111-rui.png" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:title" content="Mapping the Brain: From Cells and Circuits to Function" /> <meta name="twitter:description" content="&lt;p&gt;This lecture from Rui Costa, DVM, PhD, discusses the Allen Institute&#39;s foundational efforts to map diverse cell types and circuits in the mammalian brain using approaches such as single-cell and spatial transcriptomics, morphological and physiological analyses, and advanced light and electron microscopy. &lt;/p&gt;" /> <meta name="twitter:image" content="https://neuronline.sfn.org/-/media/Project/Neuronline/Article-Images/Scientific-Research/2024/PSL/20241111-rui.png" /> <meta name="primary_topic" content="Scientific Research" /> <meta name="topic" content="Scientific Research" /> <meta name="topic_path" content="Scientific Research+"> <meta name="type" content="Video" /> <meta property="og:type" content="Video" /> <meta name="Collection" content=" Presidential Special Lectures" /> <meta name="primary_image" content="https://neuronline.sfn.org/-/media/Project/Neuronline/Article-Images/Scientific-Research/2024/PSL/20241111-rui.png"> <meta name="speaker" content="Rui Costa, DVM, PhD" /> <meta name="audience" content="For Advanced Career, For Chapters, For Early Career, For Independent Researchers, For Mid-Career, For Trainees, For Undergraduates" /> <meta name="faq" content="NA Scientific Research" /> <meta name="publish_date" content="2024-11-11" /> <link href="/assets/Neuronline/css/bootstrap.min.css" rel="stylesheet"> <link href="/bundles/neuronlineStyles?v=YVOFc8sKR1fh2LEF68tQ2p9fs9LS--RNoRVk38fzkUc1" rel="stylesheet"/> <!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> <![endif]--> <!-- Google Tag Manager --> <script> (function (w, d, s, l, i) { w[l] = w[l] || []; w[l].push({ 'gtm.start': new Date().getTime(), event: 'gtm.js' }); var f = d.getElementsByTagName(s)[0], j = d.createElement(s), dl = l != 'dataLayer' ? 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col-lg-9 offset-lg-1 column-main article-header"> <div class="topic"> <a href="https://neuronline.sfn.org/scientific-research">Scientific Research</a> </div> <h1 class="article-title">Mapping the Brain: From Cells and Circuits to Function</h1> <div class="article-collection"> <ul> <li class="article-collection-label">Featured in:</li> <li> <a href="https://neuronline.sfn.org/collection/presidential-special-lectures"> Presidential Special Lectures</a> </li> </ul> <div class="date">Nov 11, 2024</div> </div> </div> </div> <div class="row"> <div class="col-xl-12 article-hero article-hero"> <div class="hero-content"> </div> </div> </div> <div class="row"> <div class="col-xl-8 offset-xl-2 col-lg-9 offset-lg-1 column-main article-body"> <!-- UPDATE THIS ACCOUNT BEFORE DEVELOPMENT --> <script type="text/javascript" src="//s7.addthis.com/js/300/addthis_widget.js#pubid=ra-53d937761c013c09"></script> <div style="padding:56.25% 0 0 0;position:relative;"><iframe src="https://player.vimeo.com/video/1024837746?badge=0&amp;autopause=0&amp;player_id=0&amp;app_id=58479" frameborder="0" allow="autoplay; fullscreen; picture-in-picture; clipboard-write" style="position:absolute;top:0;left:0;width:100%;height:100%;" title="Presidential Special Lecture_&amp;nbsp;Mapping the Brain_ From Cells and Circuits to Function&amp;nbsp;&amp;mdash; Rui M. Costa"></iframe></div> <script src="https://player.vimeo.com/api/player.js"></script> <p> <em> This Presidential Special Lecture was recorded Oct. 6, 2024, at Neuroscience 2024 in Chicago. </em> &nbsp; </p> <p> This lecture from Rui Costa, DVM, PhD, discusses the Allen Institute's foundational efforts to map diverse cell types and circuits in the mammalian brain using approaches such as single-cell and spatial transcriptomics, morphological and physiological analyses, and advanced light and electron microscopy. These efforts span development stages, species, and health states and investigate the dynamics of neuronal activity across brain regions and cell types during sensing, decision-making, and movement. The data, tools, and knowledge are shared openly to accelerate discovery by all neuroscientists.&nbsp; </p> <div class="article-speakers"> <h3>Speaker</h3> <div class="speaker-item"> <div class="image"> <img src="https://neuronline.sfn.org/-/media/Project/Neuronline/Bio-Images/Rectangle/2024/20241111-costa-rui.jpg?h=150&amp;w=120&amp;la=en&amp;hash=E5F57DB012969C65F18BAD12EDB22AAFFBD14EE9" alt="Costa Rui headshot" /> </div> <div class="content"> <div class="name"> Rui Costa, DVM, PhD </div> <div class="biography"> Rui M. Costa, DVM, PhD, is the president and chief executive officer of Allen Institute in Seattle, Washington. He received his DVM from the University of Lisbon and his PhD in biomedical sciences from the University of California at Los Angeles’s GABBA doctoral program. Costa studies the interactions of learning and movement and how certain brain circuitry is involved in these interactions. His findings in this field are paving paths for discovery of new and improved treatments for various movement and psychiatric disorders.   </div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix"></div> <div class="collection-navigation"> <div class="collection-navigation-inner"> <div class="collection-icon"><img src="/assets/images/neuronline/icn-collection-blue.png"></div> <div class="collection-label">More in This Collection</div> <div class="collection-title"><a href="https://neuronline.sfn.org/collection/presidential-special-lectures"> Presidential Special Lectures</a></div> <ul> <li class="previous"> <div class="item-article"> <div class="thumb"> <a href="https://neuronline.sfn.org/scientific-research/imaging-brain-chemistry-in-brain-health-and-disease-from-neurotransmitters-to-neuropeptides"><img 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