Antibody-Drug Conjugates (ADCs): the Magic Bullets for Treatment

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Culturing</a></li> <li><a href="/A1904-Organoid-Culture.html" >Organoid Culturing</a></li> <li><a href="/A1813-Neural-Factors.html" >Aneuro - Neural Factors</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html" >GMP-grade Growth Factors</a></li> <li><a href="/L-1316-CD3%20&%20CD28.html" >GMP-grade CD3/CD28 Beads</a></li> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >GMP vs Premium(Pre-GMP)</a></li> <li><a href="/A1798-cell-culture-cytokines.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Cell Activation</h2> <ul> <li><a href="/P5481-GMP-Monoclonal-Anti-Human-CD3-Antibody-%28OKT3%29-DMF-Filed.html" >Activation Antibodies</a></li> <li><a href="/A1595-ActiveMax®-Cytokines.html" >ActiveMax - Target Specific Beads</a></li> <li><a href="/P4836-ActiveMax%C2%AE-Human-T-cell-ActivationExpansion-CD3CD28-Beads-Premium-grade(Pre-GMP) (Pre-GMP)-DMF-Filed.html" >Activation CD3/CD28 Beads</a></li> <li><a href="/A2107-Solutions-for-T-Cell-Activation-and-Culture.html" >Solutions for T Cell Activation and Culture</a></li> <li><a href="/A2107-Solutions-for-T-Cell-Activation-and-Culture.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Cell Media Additives</h2> <ul> <li><a href="/A2560-ECMproteins.html" >Extracellular Matrix (ECM) Proteins</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix Basement Membrane Extracts</a></li> <li><a href="/A2612-Laminin.html" >Laminin Proteins</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cell Culture Medium</h2> <ul> <li><a href="/A2660-T-cell-culture-media.html" >CelThera™ GMP T Cell Expansion Medium</a></li> </ul> </div> <div class="pane_box_link"> <h2>Others</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> <li><a href="/A1888-Custom-GMP-Services.html" >Custom GMP Protein Services</a></li> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >More >></a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Kits & Assay Reagents <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box4 pane_boxB"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/Product_hand05.jpg" alt="Kits & Assay Reagents"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>ELISA</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Detection Kits</a></li> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Biomarker Detection Kits</a></li> <li><a href="/A1096-Inhibitor-Screening-Kits.html" >Inhibitor Screening Kits</a></li> <li><a href="/A1078-ELISA-Assay-Kits-for-Therapeutic-Antibodies.html" >Antibody Titer Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" >GENIUS™ Nuclease ELISA Kit</a></li> <li><a href="/search-keywords-protein%20A%20(SuRe).html" >Universal Protein A Quick ELISA Kit</a></li> <li><a href="/search-keywords-AAV-nature-9-w-na9.html" >AAV-related assay kits</a></li> <li><a href="/P5420-Anti-CD19-%28FMC63%29-CAR-Immunogenicity-ELISA-Kit.html" >Immunogenicity Assay Kits</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >Streptavidin (SA) Series Products</a></li> </ul> </div> <div class="pane_box_link"> <h2>qPCR Kits</h2> <ul> <li><a href="/P6109-E-coli-resDNA-Quantitative-Kit-%28qPCR%29.html" >E.Coli Residual DNA Kit</a></li> <li><a href="/P6614-CHO-resDNA-Quantitation-Kit-%28qPCR%29.html" >CHO Residual DNA Kit</a></li> <li><a href="/P6651-HEK293-resDNA-Quantitation-Kit-%28qPCR%29.html" >HEK Residual DNA Kit</a></li> <li><a href="/P6840-resDetect%E2%84%A2-E1A--SV40LTA-resDNA-Quantitation-Kit-%28qPCR%29.html" >E1A & SV40LTA Residual DNA Kit</a></li> <li><a href="/P6842-resDetect%E2%84%A2-Plasmid-resDNA-Quantitation-Kit-%28qPCR%29.html" >pDNA Residual DNA Kit</a></li> <li><a href="/search-keywords-Mycoplasma.html" >Mycoplasma Rapid Detection Kit</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Flow Cytometry</h2> <ul> <li><a href="/P7817-ClinMax%E2%84%A2-Human-TBNK-6-color-Cocktail-Flow-Panel.html" >Human TBNK 6-color Cocktail Flow Panel</a></li> <li><a href="/search-keywords-Th1/Th2%20cytokine.html" >Human Th1/Th2 Cytokine Kit (Flow Cytometry Multiplex Bead Assay)</a></li> <li><a href="/A1128-Pre-Coupling-Magnetic-Beads.html" >Pre-coupled Magnetic Beads</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplexed Flow Cytometry</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >Streptavidin (SA) Series Products</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div 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class="layui-menu-body-title">Viral Antigens&Antibodies&Kits <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box5 pane_boxB"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/Product_hand02.jpg" alt="Viral Antigens"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>SARS-CoV-2</h2> <ul> <li><a href="/A1226-SARS-CoV-2_spike_mutants.html" >Variants of SARS-CoV-2 SARS-CoV-2 Related Products</a></li> <li><a href="/A1111-SARS-CoV-2-Related-Products.html" >SARS-CoV-2 Related Products</a></li> <li><a href="/A1167-Solutions-for-COVID-19-vaccine-safety-and-immunogenicity-evaluation.html" >Workflow for Vaccine R&D</a></li> </ul> </div> <div class="pane_box_link"> <h2>Varicella Zoster Virus</h2> <ul> <li><a href="/search-keywords-Glycoprotein E (VZV).html" >Glycoprotein E (VZV Antigen)</a></li> <li><a href="/search-keywords-VZV-nature-1-w-na1.html" >Anti-Glycoprotein E 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href="/search-nature-1-molecule-1724-keywords-RSV-w-na1_mo1724.html" >Anti-RSV Post-fusion Antibody</a></li> <li><a href="/A2222-RSV.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Rabies Virus</h2> <ul> <li><a href="/L-1235-Glycoprotein%20(RABV).html" >Glycoprotein</a></li> <li><a href="/L-1739-Nucleoprotein.html" >Nucleoprotein</a></li> <li><a href="/P7526-Mouse-Anti-RABV-Nucleoprotein-Antibody-IgG-Titer-Serologic-Assay-Kit-%28ELISA%29.html" >Anti-RABV Nucleoprotein Antibody Kit </a></li> <li><a href="/P6055-Mouse-Anti-RABV-Glycoprotein-Antibody-IgG-Titer-Serologic-Assay-Kit-%28ELISA%29.html" >Anti-RABV Glycoprotein Antibody Kit </a></li> <li><a href="/A2438-RABV.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Herpes Virus</h2> <ul> <li><a href="/A2374-VZV-vaccine.html" >VZV</a></li> <li><a href="/A1658-virustop.html#module=ViruStop7" >HSV</a></li> <li><a href="/A1658-virustop.html#module=ViruStop13" >EBV</a></li> <li><a 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Ribbon Protein Marker</a></li> <li><a href="/A1669-ComboX%E2%84%A2-Universal-Tools-for-Your-Antibody-Drug-Development.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Cell Lines</h2> <ul> <li><a href="/A2220-Reporter-Cell-Lines.html" >Reporter cell lines</a></li> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Electrophysiological Probes</h2> <ul> <li><a href="/A2183-DBC.html" >Deep Array Probes</a></li> <li><a href="/A2183-DBC.html" >More >></a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2> Experimental Instruments and Equipments</h2> <ul> <li><a href="/P7052-Automatic-Nucleic-Acid-Extraction-System.html" >Automatic Nucleic Acid Extraction System</a></li> <li><a href="/P7052-Automatic-Nucleic-Acid-Extraction-System.html" >More >></a></li> </ul> </div> </div> </div> </li> <div class="layui-menu-body-titleA"> Search by Modality </div> <li class="layui-menu-item-parent" > <div class="layui-menu-body-title upA"> <a href="/A2471-Cell-_Therapy-_Solutions.html">Cell Therapy </a><i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_1" > <div class="layui-menu-body-title layui-menu-body-title2"> Cell Therapy </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow" > <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>CAR Targets</h2> <ul> <li><a href="/A1088-CD19%EF%BC%9Aa-validated-therapeutic-target-for-B-cell-malignancies.html" >CD19 Protein</a></li> <li><a href="/search-keywords-BCMA-molecule-36-w-mo36.html" >BCMA Protein</a></li> <li><a href="/search-keywords-MSLN.html" >MSLN Protein</a></li> <li><a href="/A1971-Hematological-Malignancies.html" >Hematologica Malignancies CAR Targets</a></li> <li><a href="/A1861-Solid-Tumor-CAR-Targets.html" >Solid Tumor CAR Targets</a></li> <li><a href="/A1041-Targets-of-CAR-T-Cell-Therapy.html" >More Targets >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Universal CAR Detection Tool</h2> <ul> <li><a href="/search-keywords-G4S%20Linker.html" >Anti-G4S linker Antibody</a></li> <li><a href="/L-422-Protein%20L.html" >Protein L</a></li> </ul> </div> <div class="pane_box_link"> <h2>Other Target Proteins</h2> <ul> <li><a href="/A1656-MHC-Class-I-Complex-Custom-Service.html" >MHC-peptide Complexes</a></li> <li><a href="/A1536-Proteins-for-Neuroscience.html" >Aneuro - Proteins for Neuroscience</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>General Proteins</h2> <ul> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA Series Products</a></li> </ul> </div> <div class="pane_box_link"> <h2>Drug Screening Service</h2> <ul> <li><a href="/A1151-SPR-BLI-analytical-service.html" >SPR /BLI analytical service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics Development</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cell Culture Products</h2> <ul> <li><a href="/A1798-cell-culture-cytokines.html" >Cell Culture Growth Factors & Antibodies</a></li> <li><a href="/A2660-T-cell-culture-media.html" >CelThera™ GMP T Cell Expansion Medium</a></li> <li><a href="/A1595-ActiveMax®-Cytokines.html" >ActiveMax Cell Activation Beads</a></li> <li><a href="/A2560-ECMproteins.html" >Extracellular Matrix (ECM) Proteins</a></li> <li><a href="/A2097-iPSC-Culturing.html" >CMC Production Process of iPSC-based Cell Therapy</a></li> <li><a href="/A2612-Laminin.html" >Laminin Proteins for Clinical iPSC Banking</a></li> <li><a href="/A1904-Organoid-Culture.html" >Cytokines for Organoid Culture</a></li> <li><a href="/A1813-Neural-Factors.html" >Aneuro - Neural Factors</a></li> <li><a href="/A2495-TcellCMC.html" >CMC Production Process of Adoptive T Cell Therapies</a></li> </ul> </div> <div class="pane_box_link"> <h2>Premium(Pre-GMP) grade Raw Materials</h2> <ul> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >Premium(Pre-GMP) Growth Factors</a></li> <li><a href="/P5481-GMP-Monoclonal-Anti-Human-CD3-Antibody-%28OKT3%29-DMF-Filed.html" >GMP Grade Antibodies</a></li> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP Grade GENIUS™Nuclease </a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> <li><a href="/A1595-ActiveMax®-Cytokines.html" >ActiveMax Cell Activation Beads</a></li> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >Key Raw Materials for CGT</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal Products</h2> <ul> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP Grade GENIUS™Nuclease </a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> </ul> </div> <div class="pane_box_link"> <h2>Gene Editing Products</h2> <ul> <li><a href="/A1657-CRISPR-Cas-technology.html" >GENPower - Cas Enzymes</a></li> <li><a href="/A1301-enzyme-products.html#mRNA_enzymeA" >mRNA Synthesis Enzymes</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Large-Scale Manufacturing</h2> <ul> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >GMP-grade Raw Materials</a></li> <li><a href="/A1888-Custom-GMP-Services.html" >GMP Protein Services</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_3 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_c.jpg" alt="CMC-Quality Control"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Residual Detection-resDetect</h2> <ul> <li><a href="/A2146-Nuclease-Detection-Kits.html" target="_blank" >Residual Host Cell DNA / RNA Detection Kits</a></li> <li><a href="/search-keywords-Activity.html" target="_blank" >RNase / DNase Detection Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" target="_blank" >GENIUS™ Nuclease Residual Detection Kit</a></li> <li><a href="/P7814-resDetect%E2%84%A2-BSA-ELISA-Kit.html" target="_blank" >Residual BSA ELISA Kit</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html#pro" target="_blank" >Residual Cell Culture Materials Detection Kits</a></li> <li><a href="/P6991-resDetect%E2%84%A2-Kanamycin-ELISA-Kit.html" target="_blank" >Residual Antibiotics Detection Kits</a></li> <li><a href="/P7281-resDetect%E2%84%A2-HIV-1-p24-ELISA-Kit-%28Residue-Testing%29.html" target="_blank" >Residual HIV-1 p24 ELISA Kit</a></li> <li><a href="/search-keywords-Mycoplasma.html" target="_blank">Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" target="_blank">Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="/A2504-resDetect-CGT.html" target="_blank" >CGT CMC Manufacturing Process Residue Detection Solutions</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>CAR Detection Tools</h2> <ul> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1118-mAb-for-Anti-CD19-CAR-Detection-Flow-Cytometry-Validated.html" >Anti-FMC63 Antibody</a></li> <li><a href="/L-1788-G4S%C2%A0linker.html" >Anti-G4s Linker Antibody</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >ComboX Isotype Controls</a></li> </ul> </div> <div class="pane_box_link"> <h2>Potency Assays</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line - CellInsight</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Pre-clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div 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>Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Audit & Documentation support</h2> <ul> <li><a href="/A1148-FDA-DMF-Filed-Proteins.html" >FDA DMF Filed Proteins</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html" >GMP Regulatory Support Files</a></li> </ul> </div> <div class="pane_box_link"> <h2>Companion Diagnostics Tools</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_5 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightA_e.jpg" alt="Clinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1118-mAb-for-Anti-CD19-CAR-Detection-Flow-Cytometry-Validated.html" >Anti-FMC63 Antibody</a></li> <li><a href="/L-1788-G4S%C2%A0linker.html" >Anti-G4s Linker Antibody</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Immunogenicity Studies</h2> <ul> <li><a href="/A1118-mAb-for-Anti-CD19-CAR-Detection-Flow-Cytometry-Validated.html" >Anti-FMC63 Antibody</a></li> <li><a href="/P5420-Anti-CD19-%28FMC63%29-CAR-Immunogenicity-ELISA-Kit.html" >Immunogenicity Anti-FMC63 ELISA kit</a></li> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining - Fluorescent Labeled Proteins</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> </ul> </div> </div> </div> </li> </ul> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title upA"> Gene Therapy <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_2"> <div class="layui-menu-body-title layui-menu-body-title2"> Gene Therapy </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Gene Editing</h2> <ul> <li><a href="/A1657-CRISPR-Cas-technology.html" >GENPower - Cas Enzymes</a></li> </ul> </div> <div class="pane_box_link"> <h2>AAV Titer Quantitation</h2> <ul> <li><a href="/P7031-AAV5-Titration-ELISA-Kit-%28Fast%29.html" >AAV5 Titration ELISA Kit (Fast)</a></li> <li><a href="/P7157-AAV5-Titration-ELISA-Kit.html" >AAV5 Titration ELISA Kit </a></li> <li><a href="/P7823-AAV3-Titration-ELISA-Kit-%28Fast%29.html" >AAV3 Titration ELISA Kit (Fast) </a></li> <li><a href="/P7100-AAV3-Titration-ELISA-Kit.html" >AAV3 Titration ELISA Kit</a></li> <li><a href="/P7735-AAV8-Titration-ELISA-Kit-%28Fast%29.html" >AAV8 Titration ELISA Kit (Fast)</a></li> <li><a href="/P7736-AAV8-Titration-ELISA-Kit.html" >AAV8 Titration ELISA Kit</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_b.jpg" 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href="/P7157-AAV5-Titration-ELISA-Kit.html" >AAV5 Titration ELISA Kit </a></li> <li><a href="/P7823-AAV3-Titration-ELISA-Kit-%28Fast%29.html" >AAV3 Titration ELISA Kit (Fast) </a></li> <li><a href="/P7100-AAV3-Titration-ELISA-Kit.html" >AAV3 Titration ELISA Kit</a></li> <li><a href="/P7735-AAV8-Titration-ELISA-Kit-%28Fast%29.html" >AAV8 Titration ELISA Kit (Fast)</a></li> <li><a href="/P7736-AAV8-Titration-ELISA-Kit.html" >AAV8 Titration ELISA Kit</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Large-Scale Manufacturing</h2> <ul> <li><a href="/A1751-Key-Raw-Materials-for-Cell-and-Gene-Therapy.html" >GMP-grade Raw Materials</a></li> <li><a href="/A1888-Custom-GMP-Services.html" >GMP Protein Services</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel 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(Fast) </a></li> <li><a href="/P7100-AAV3-Titration-ELISA-Kit.html" >AAV3 Titration ELISA Kit</a></li> <li><a href="/P7735-AAV8-Titration-ELISA-Kit-%28Fast%29.html" >AAV8 Titration ELISA Kit (Fast)</a></li> <li><a href="/P7736-AAV8-Titration-ELISA-Kit.html" >AAV8 Titration ELISA Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Pre-clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacodynamics Studies</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li><li><a href="/A1904-Organoid-Culture.html" >Organoid Culture Cytokines</a></li> <li><a href="/A1718-Pre-formed-Fibrils-(PFFs).html" >Pre-formed Fibrils (Aneuro)</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix for Organoid Culture</a></li> <li><a href="/A2183-DBC.html" >Diagnostic Biochips</a></li> </ul> </div> <div class="pane_box_link"> <h2>Security Studies</h2> <ul> <li><a href="/search-keywords-AAV%20antibody%20kit.html" >Anti-AAV Antibody ELISA Kit</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> <div class="pane_box_link"> <h2>Audit & Documentation support</h2> <ul> <li><a href="/A1148-FDA-DMF-Filed-Proteins.html" >FDA DMF Filed Proteins</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html" >GMP Regulatory Support Files</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics Tools</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_5 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightB_e.jpg" alt="Clinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> <div class="pane_box_link"> <h2>Security Studies</h2> <ul> <li><a href="/search-keywords-AAV%20antibody%20kit.html" >Anti-AAV Antibody ELISA Kit</a></li> </ul> </div> </div> </div> </li> </ul> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title upA"> <a href="/A2356-Therapeutic-Antibody-Page.html" >Therapeutic Antibodies </a><i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_3"> <div class="layui-menu-body-title layui-menu-body-title2"> Therapeutic Antibodies </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Target Proteins</h2> <ul> <li><a href="/A1288-Cytokine.html" >Cytokine Targets</a></li> <li><a href="/A974-Immune-Checkpoint-Proteins.html" >Checkpoint Proteins</a></li> <li><a href="/A2117-Agonist-Target-Proteins.html" >Agonist</a></li> <li><a href="/A1290-Transmembrane-Proteins-Platform.html" >FLAG</a></li> <li><a href="/A1536-Proteins-for-Neuroscience.html" >Aneuro</a></li> <li><a href="/A1265-Tumor-microenvironment.html" >Tumor Microenvironment</a></li> <li><a href="/A1222-Bispecific-antibody-targets-and-more.html" >Bispecifc Antibody Targets</a></li> <li><a href="/A1656-MHC-Class-I-Complex-Custom-Service.html" >MHC Complexes</a></li> </ul> </div> <div class="pane_box_link"> <h2>Antibody Screening</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1096-Inhibitor-Screening-Kits.html" >Inhibitor Screening Kits</a></li> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining Fluorescent Labeled Proteins</a></li> <li><a href="/A1128-Pre-Coupling-Magnetic-Beads.html" >Pre-coupled Magnetic Beads</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1969-Recombinant-Antibody-Services.html" >Recombinant Antibody Expression Services</a></li> <li><a href="/A1151-SPR-BLI-analytical-service.html" >SPR /BLI analytical service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Fc Proteins</h2> <ul> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Fc Proteins</a></li> <li><a href="/A712-Fc-Receptor-Proteins.html" >Fc Receptor</a></li> <li><a href="/A1394-FcRn%EF%BC%88Neonatal-Fc-Receptor%EF%BC%89.html" >Neonatal Fc Receptor</a></li> <li><a href="/P7366-Human-FcRn-binding-Kit-%28TR-FRET%29.html" >FcRn Binding Kit</a></li> </ul> </div> <div class="pane_box_link"> <h2>Cell Line (CellInsight)</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Companion Diagnostics</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal</h2> <ul> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP GENIUS Nuclease</a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_3 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_c.jpg" alt="CMC-Quality Control"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Residual Detection-resDetect</h2> <ul> <li><a href="/A2146-Nuclease-Detection-Kits.html" >Host DNA/Protein Quantitative Kits</a></li> <li><a href="/P7433-resDetect%E2%84%A2-Universal-Protein-A-Quick-ELISA-Kit-%28Boiling-free%29.html" >Residual Affinity Ligands Detection Kits</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html#pro" >Residual Cell Culture Materials Detection Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" >GENIUS™ Nuclease Residual Detection Kit</a></li> <li><a href="/P6991-resDetect%E2%84%A2-Kanamycin-ELISA-Kit.html" >Residual Antibiotics Detection Kits</a></li> <li><a href="/A2543-resDetect-Antibody.html" >Therapeutic antibodies CMC Manufacturing Process Residue Detection Solutions</a></li> <li><a href="/search-keywords-Mycoplasma.html" >Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" >Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Other Quality Control Products</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Isotype Control</a></li> <li><a href="/A2154-Tool-enzymes.html" >Enzymes for Antibody Characterization Analysis</a></li> <li><a href="/A1794-MALS-UNcle-Platform.html" >Quality Characterization Analytical Services</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cytokine Release Detection</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine ELISA Kits</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Preclinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1089-Anti-idiotypic-Antibodies.html" >Anti-idiotypic Antibodies</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1078-ELISA-Assay-Kits-for-Therapeutic-Antibodies.html" >PK ELISA Assays</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Immunogenicity Studies</h2> <ul> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic & ADA Assay Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Pharmacodynamics Studies</h2> <ul> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li><li><a href="/A1904-Organoid-Culture.html" >Organoid Culture Cytokines</a></li> <li><a href="/A1718-Pre-formed-Fibrils-(PFFs).html" >Pre-formed Fibrils (Aneuro)</a></li> <li><a href="/A2145-BME.html" >Mogengel Matrix for Organoid Culture</a></li> <li><a href="/A2183-DBC.html" >Diagnostic Biochips</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Audit & Documentation support</h2> <ul> <li><a href="/A1148-FDA-DMF-Filed-Proteins.html" >FDA DMF Filed Proteins</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html" >GMP Regulatory Support Files</a></li> </ul> </div> <div class="pane_box_link"> <h2>Companion Diagnostics Tools</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_5 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightC_e.jpg" alt="Clinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1089-Anti-idiotypic-Antibodies.html" >Anti-idiotypic Antibodies</a></li> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody Development Service</a></li> <li><a href="/A1078-ELISA-Assay-Kits-for-Therapeutic-Antibodies.html" >PK ELISA Assays</a></li> <li><a href="/A1326-Enzyme-Linked-Immunosorbent-Assay-%28ELISA%29-Service.html" >PK ELISA Development Service</a></li> </ul> </div> <div class="pane_box_link"> <h2>Immunogenicity Studies</h2> <ul> <li><a href="/A1320-Anti-Idiotypic-Antibody.html" >Anti-idiotypic Antibody ADA Development Service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Toxicity Studies</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine Release Assay Kits - ClinMax</a></li> <li><a href="/search-keywords-Th1/Th2 cytokine.html" >Multiplex Cytokine Assay Kits</a></li> <li><a href="/A2398-Disease-and-human-models.html" >Organoid Toolbox</a></li> </ul> </div> </div> </div> </li> </ul> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title upA"> Antibody Drug Conjugates <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel layui-pane2_1 layui-pane2_1_4"> <div class="layui-menu-body-title layui-menu-body-title2"> Antibody Drug Conjugates </div> <ul> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Discovery and Development <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_1 pane_boxD pane_boxA upA_suow"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_a.jpg" alt="Discovery & Development"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Target Proteins</h2> <ul> <li><a href="/A1210-Targets-for-Antibody-Drug-Conjugates.html#module=kit1" >ADC Drug Targets</a></li> <li><a href="/A1288-Cytokine.html" >Cytokine Targets</a></li> <li><a href="/A974-Immune-Checkpoint-Proteins.html" >Checkpoint Proteins</a></li> <li><a href="/A2117-Agonist-Target-Proteins.html" >Agonist</a></li> <li><a href="/A1290-Transmembrane-Proteins-Platform.html" >FLAG</a></li> <li><a href="/A1536-Proteins-for-Neuroscience.html" >Aneuro</a></li> <li><a href="/A1265-Tumor-microenvironment.html" >Tumor Microenvironment</a></li> <li><a href="/A1222-Bispecific-antibody-targets-and-more.html" >Bispecifc Antibody Targets</a></li> <li><a href="/A1656-MHC-Class-I-Complex-Custom-Service.html" >MHC Complexes</a></li> </ul> </div> <div class="pane_box_link"> <h2>Antibody Screening</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a href="/A1096-Inhibitor-Screening-Kits.html" >Inhibitor Screening Kits</a></li> <li><a href="/A1332-Star-Staining-Proteins-Platform.html" >Star Staining Fluorescent Labeled Proteins</a></li> <li><a href="/A1128-Pre-Coupling-Magnetic-Beads.html" >Pre-coupled Magnetic Beads</a></li> <li><a href="/A1670-Streptavidin(SA)-Series-Products.html" >SA series Products ComboX</a></li> <li><a href="/A1969-Recombinant-Antibody-Services.html" >Recombinant Antibody Expression Services</a></li> <li><a href="/A1151-SPR-BLI-analytical-service.html" >SPR /BLI analytical service</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Fc Proteins</h2> <ul> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Fc Proteins</a></li> <li><a href="/A712-Fc-Receptor-Proteins.html" >Fc Receptor</a></li> <li><a href="/A1394-FcRn%EF%BC%88Neonatal-Fc-Receptor%EF%BC%89.html" >Neonatal Fc Receptor</a></li> <li><a href="/P7366-Human-FcRn-binding-Kit-%28TR-FRET%29.html" >FcRn Binding Kit</a></li> </ul> </div> <div class="pane_box_link"> <h2>ADC Reagents</h2> <ul> <li><a href="/A2584-ADC-Conjugation-Kit.html" >AGLink Conjugation Kit</a></li> <li><a href="/A1210-Targets-for-Antibody-Drug-Conjugates.html" >Proteases for Peptide Linker</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cell Line (CellInsight)</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> <div class="pane_box_link"> <h2>Companion Diagnostics</h2> <ul> <li><a href="/A2176-IHC-antibody.html" >IHC Antibodies</a></li> <li><a href="/A2246-Immunohistochemistry-%28IHC%29-Kit.html" >Immunohistochemistry (IHC) Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Manufacturing <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_2 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_b.jpg" alt="CMC-Manufacturing"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Nucleic Acid Removal</h2> <ul> <li><a href="/P5787-GMP-GENIUS%E2%84%A2Nuclease-DMF-Filed.html" >GMP GENIUS Nuclease</a></li> <li><a href="/P7181-GMP-Salt-Active-GENIUS%E2%84%A2Nuclease.html" >Salt Active GENIUS™Nuclease</a></li> </ul> </div> <div class="pane_box_link"> <h2>Conjugation Kits</h2> <ul> <li><a href="/A2584-ADC-Conjugation-Kit.html" >AGLink Conjugation Kit</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Quality Control <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_3 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_c.jpg" alt="CMC-Quality Control"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Residual Detection-resDetect</h2> <ul> <li><a href="/A2146-Nuclease-Detection-Kits.html" >Host DNA/Protein Quantitative Kits</a></li> <li><a href="/P7433-resDetect%E2%84%A2-Universal-Protein-A-Quick-ELISA-Kit-%28Boiling-free%29.html" >Residual Affinity Ligands Detection Kits</a></li> <li><a href="/A1557-GMP-Grade-Cytokines.html#pro" >Residual Cell Culture Materials Detection Kits</a></li> <li><a href="/P7571-resDetect%E2%84%A2-GENIUS%E2%84%A2-Nuclease-ELISA-Kit-%28Residue-Testing%29.html" >GENIUS™ Nuclease Residual Detection Kit</a></li> <li><a href="/search-keywords-Mycoplasma.html" >Mycoplasma Rapid Detection Kit</a></li> <li><a href="/P7954-Recombinant-Factor-C-Endotoxin-Detection-Kit.html" >Recombinant Factor C Endotoxin Detection Kit</a></li> <li><a href="https://www.acrobiosystems.com/A2331-resDetect.html" >More >></a></li> </ul> </div> <div class="pane_box_link"> <h2>Other Quality Control Products</h2> <ul> <li><a href="/A2221-Stable-cell-line.html" >Overexpression cell line</a></li> <li><a href="/A1391-IgG-Fc-Proteins%E2%80%94%E2%80%94Ideal-Isotype-Control-for-IgG-Structured-Drug-Development.html" >IgG Isotype Control</a></li> <li><a href="/A2154-Tool-enzymes.html" >Enzymes for Antibody Characterization Analysis</a></li> <li><a href="/A1794-MALS-UNcle-Platform.html" >Quality Characterization Analytical Services</a></li> <li><a href="/A2219-Cell-Line-Customize-Service.html" >Cell Line Customization services</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>ADC Payload Evaluation</h2> <ul> <li><a href="/A2226-Anti-payload-antibodies.html" >Anti-payload Antibodies</a></li> </ul> </div> <div class="pane_box_link"> <h2>Antibody Enzymes</h2> <ul> <li><a href="/A1301-enzyme-products.html" >Antibody Characterization</a></li> </ul> </div> </div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Cytokine Release Detection</h2> <ul> <li><a href="/A1781-Cytokine-detection-ELISA-kits.html" >Cytokine ELISA Kits</a></li> </ul> </div> </div> </div> </li> <li class="layui-menu-item-parent" lay-options="{type: 'parent'}"> <div class="layui-menu-body-title"> Pre-clinical Research <i class="layui-icon layui-icon-right"></i> </div> <div class="layui-menu-body-panel pane_box pane_box2_4 pane_boxD"> <div class="pane_box_img"><img width="100%" src="https://www.acrobiosystems.com/static/main/images/HomePhotoA/home_rightD_d.jpg" alt="Preclinical Studies"></div> <div class="layui-col-md12"> <div class="pane_box_link"> <h2>Pharmacokinetics Studies</h2> <ul> <li><a href="/A716-Biotinylated-Protein.html" >Biotinylated Proteins</a></li> <li><a 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window.location.href = 'https://www.acrobiosystems.com/A1314-Request-for-ADCs-eBook.html'+search;}) })</script><h1 class="productTit" style="font-size:26px">Antibody-Drug Conjugates (ADCs): the Magic Bullets for Treatment</h1><div class="productMabsol" id="article-pd-1"><div class="productBanner"><img src="/static/main/images/adc/0515_banner.jpg" alt="Antibody-Drug Conjugates (ADCs): the Magic Bullets for Treatment" title="Antibody-Drug Conjugates (ADCs): the Magic Bullets for Treatment" width="100%"/></div><div class="productLink productLink6"><div class="box current"><a href="javascript:;">Hot Products</a></div><div class="box"><a href="javascript:;">Product list</a></div><div class="box"><a href="javascript:;">ADC targets</a></div><div class="box"><a href="javascript:;">Proteases</a></div><div class="box"><a href="javascript:;">Conjugation kits</a></div><div class="box"><a href="javascript:;">PK analysis</a></div><div class="box"><a href="javascript:;">service</a></div></div><div class="productMain"><div class="productSection"><div class="clear"></div><div class="productTit">Background</div><div style="margin:0 auto; background-color:#f9e7e7 !important; float:left; padding:20px auto;" class="public_img_text_box public_img_l_r layui-col-space12"><div class="layui-col-md6" style="background-color:#f9e7e7 !important; padding:20px 20px 0px 20px;"><p class="public_text_dec" id="p1">In recent years, Antibody-Drug Conjugates (ADCs) may serve as a novel therapeutic modality for many cancer patients. Indeed, three key elements define an ADC: the antibody directed against a specific tumor antigen, the cytotoxin/payload and the cleavable/uncleavable linker connecting the payload to the antibody <sup>[1]</sup>. Specific target recognition and effective toxin make ADCs veritable "magic bullet". These 'magic bullets' deliver treatment that is both highly targeted and highly potent, seeking out and attacking cancerous cells throughout the body, while avoiding harm to healthy cells. Reasonable selection of targets, antibody, linker, payload, and their rational combinations, as well as conjugation methods are crucial for an effective treatment. Among these elements, target selection, linker selection, conjugation methods and evaluating preclinical /clinical efficacy are considered critical factors for ADCs development. <a id="ADCs-eBook" target="_blank" style="font-weight: bold;color: #cc3536; text-decoration: underline;">>>> Download the ebook: Key point of ADCs design</a></p><div class="public_text_dec" style="font-weight:bold; margin-top:20px;">To meet the needs of ADCs development, ACROBiosystems can provide:</div><div class="characterDec"><div class="lf"><div class="characterDec" style="color:#000 !important;"><span>A variety of high-quality target proteins;</span><br/><span><a href="/search-molecule-377_378-keywords-%20MMP-w-mo377_mo378.html" style="color:#cc3500;text-decoration: underline;" target="_blank">MMPs</a>/<a href="/search-keywords-Cathepsin.html" style="color:#cc3500;text-decoration: underline;" target="_blank">Cathepsin</a>/<a href="/L-415-PLAU.html" style="color:#cc3500;text-decoration: underline;">uPA</a> for cleavable linker;</span><br/><span>ADC site-specific conjugation kits;</span><br/><span>Anti-payload antibodies, anti-idiotypic antibodies(ADA) for immunogenicity and PK analysis.</span><br/><span>SPR/BLI analytical & anti-Idiotypic antibody development service.</span></div></div></div></div><div class="layui-col-md6" style="background-color:#f9e7e7 !important; padding:10px 0px;"><img src="/static/main/images/adc/adc_b+.png" alt="Structure of ADCs" title="Structure of ADCs" width="100%"/></div><div class="clear"></div><div class="public_text_dec" style="width:85%; margin:5px auto 10px; border-radius:10px; padding:10px; height:auto;text-align:center; font-size:14px; margin-top:20px; line-height:24px; font-weight:bold; border:2px dotted #fde7c9; color:#FFF; background:#cc3536; opacity:0.7;" id="ADCA1">All products and services can meet the entire process of ADCs from antibody preparation, initial screening, production to quality control, facilitating your ADCs development.</div><div class="clear"></div></div><div class="clear"></div><div class="productTit">Hot Products</div><div class="public_img_text_box layui-col-space10 molecular_box" id="ADC"><div class="layui-col-md6"><div class="molecular_div"><a class="div_title" href="#p3">High-quality ADC target proteins</a><div class="div_content"><div class="content_left"><img src="/static/main/images/adc/box_1.jpg" alt="ADC-related target proteins" title="ADC-related target proteins"/></div><div class="content_right"><p class="content_title">Features</p><ol class=" list-paddingleft-2"><li><p>>> 50+ ADC targets, such as <a style="color:#cc3500;text-decoration: underline;" target="_blank" href="/L-480-TROP-2.html">Trop-2</a>, <a style="color:#cc3500;text-decoration: underline;" target="_blank" href="/L-907-Nectin-4.html">Nectin-4</a>,<a style="color:#cc3500;text-decoration: underline;" target="_blank" href="/L-1103-LIV-1.html">LIV-1</a> and <a style="color:#cc3500;text-decoration: underline;" target="_blank" href="/L-432-ROR1.html">ROR1</a>;</p></li><li><p>>> Various species & tag;</p></li><li><p>>> High purity verified by MALS;</p></li><li><p>>> High bioactivity verified by ELISA / SPR / BLI / FACS, etc.</p></li></ol></div><div class="clear"></div><p class="content_title">Applications</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p>Suitable for immunization / antibody screening / cross-reactivity/cell-based assay/QC.</p></li></ul><div class="clear"></div><p class="content_title">Featured products</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p style="font-weight:bold;">Exclusive <a href="/L-1103-LIV-1.html" target="_blank" style="color:#cc3500;text-decoration: underline;" data-cl-id="2491713698">LIV-1</a> proteins:</p></li><li><p>✔ Multiple species: Human, Mouse, Cynomolgus, Rat, etc.;</p></li><li><p>✔ Expression sequences were designed based on the SGN-LIV1A binding epitope.</p></li></ul></div></div></div><div class="layui-col-md6" id="linker"><div class="molecular_div"><a class="div_title" href="#p4">Proteases for peptide linker</a><div class="div_content"><div class="content_left"><img src="/static/main/images/adc/box_2.jpg" alt="Cathepsin B, Proteases for peptide linker in ADCs" title="Cathepsin B, Proteases for peptide linker in ADCs"/></div><div class="content_right"><p class="content_title">Features</p><ol class=" list-paddingleft-2"><li><p>>> Comprehensive products: <a href="/search-keywords-Cathepsin.html" style="color:#cc3500;text-decoration: underline;" target="_blank">Cathepsin</a>, <a href="/search-molecule-377_378-keywords-%20MMP-w-mo377_mo378.html" style="color:#cc3500;text-decoration: underline;" target="_blank" data-cl-id="4270627738">MMPs</a> and <a href="/L-415-PLAU.html" style="color:#cc3500;text-decoration: underline;">uPA</a> etc.;</p></li><li><p>>> Natural conformation: HEK293 expressed protein to ensure the natural structure;</p></li><li><p>>> High enzyme activity: enzyme activity > 2,500 pmol/min/µg.</p></li></ol></div><div class="clear"></div><p class="content_title" id="ADCA2">Applications</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p>✔ Evaluate the effect of proteases cleavage of linker to ensure the efficient release of the intracellular payloads.</p></li></ul></div></div></div></div><div class="public_img_text_box layui-col-space10 molecular_box"><div class="layui-col-md6" id="AGLink"><div class="molecular_div" style="min-height:520px;"><a class="div_title" href="#p7" style=" font-size:1.2em !important;">AGLink™ ADC site-specific conjugation kits</a><div class="div_content"><div class="content_left"><img src="/static/main/images/adc/adc_new_28.png" alt="AGLink™ ADC site-specific conjugation kits" title="AGLink™ ADC site-specific conjugation kits"/></div><div class="content_right"><p class="content_title">Features</p><ol class=" list-paddingleft-2"><li><p>>> Site-specific conjugation through Fc-glycan with high conjugation efficiency</p></li><li><p>>> Uniform DAR value and highly homogeneous ADC products</p></li><li><p>>> Universal and efficient: No need of amino acid sequence engineering.</p></li><li><p>>> Easy to use: One-pot conjugation</p></li><li><p>>> Two options: DAR2 and DAR4 ADC kits</p></li><li><p>>> High stability of conjugates</p></li><li><p>>> Comprehensive components for easy usage, batch consistency of enzyme</p></li></ol></div><div class="clear"></div><p class="content_title">Applications</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p>✔  Conjugation of ADCs in preclinical development</p></li></ul><div class="clear"></div><p class="content_title">Featured products</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p>AGLink ADC Conjugation Kit (MMAE, DAR2&4, 1mg)(Cat. No. <a href="/P7643-AGLink%C2%AE-ADC-Conjugation-Kit-%28MMAE-DAR24-1mg%29.html" target="_blank" style="color: #cc3536;text-decoration: underline;">ADC-P005</a>)and AGLink ADC Conjugation Kit(MMAE, DAR2&4, 5mg)(Cat. No. <a href="/P7644-AGLink%C2%AE-ADC-Conjugation-Kit-%28MMAE-DAR24-5mg%29.html" target="_blank" style="text-decoration: underline;color: #cc3536;">ADC-P009</a>)with high homogeneity</p></li></ul></div></div></div><div class="layui-col-md6" id="PK"><div class="molecular_div" style="min-height:520px;"><a class="div_title" href="#p5">Tools for ADCs PK analysis</a><div class="div_content"><div class="content_left"><img src="/static/main/images/adc/box_3.jpg" alt="Anti-MMAE antibodies and anti-idiotypic antibodies for ADCs PK analysis" title="Anti-MMAE antibodies and anti-idiotypic antibodies for ADCs PK analysis"/></div><div class="content_right"><p class="content_title">Features</p><ol class=" list-paddingleft-2"><li><p>>> Comprehensive products: anti-MMAE antibodies and anti-idiotypic antibodies;</p></li><li><p>>> High specificity & affinity;</p></li><li><p>>> High sensitivity & stability.</p></li></ol></div><div class="clear"></div><p class="content_title">Applications</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p>✔ Positive reference of ADCs preclinical / clinical immunogenicity;</p></li><li><p>✔ PK analysis;</p></li><li><p>✔ Anti-payload antibodies: Qualitative detection of DAR value.</p></li></ul><div class="clear"></div><p class="content_title" id="ADCA3">Featured products</p><div class="clear"></div><ul class=" list-paddingleft-2"><li><p>The activity of anti-MMAE monoclonal antibody (Cat. No.<a style="color:#cc3500;text-decoration: underline;" href="/P4326-Mouse-Anti-MMAE-Antibody-Mouse-IgG1-%28MALS-verified%29.html" target="_blank">MME-M5252</a>) is verified by binding to Disitamab Vedotin (RC-48) with a linear range of 0.1-2 ng/mL.</p></li></ul></div></div></div></div><div class="clear"></div><div class="public_img_text_box layui-col-space10 molecular_box" id="service" style="float:left; margin-top:20px;"><div class="layui-col-md12" id="p2_4"><div class="molecular_div" style="height:390px;"><a class="div_title" href="#p6" style="width:460px;">SPR/BLI analytical & ADA development service</a><div class="clear"></div><div class="layui-col-md6" style="padding-top:10px !important;"><div class="div_content"><div class="content_left"><img src="/static/main/images/adc/box_4.jpg" alt="SPR /BLI analytical service" title="SPR /BLI analytical service"/></div><div class="content_right"><p><a style="color:#cc3500;text-decoration: underline;" href="/A1151-SPR-BLI-analytical-service.html">SPR /BLI analytical service</a></p><ol class=" list-paddingleft-2"><li><p><span>●</span> ACRO proteins supplied for free</p></li><li><p><span>●</span> Only your samples are required</p></li><li><p><span>●</span> Reports follows all IND requirements</p></li></ol></div><div class="clear"></div><ul class=" list-paddingleft-2"><p class="content_title">Applications</p><li><p>Based on the Biacore 8K and ForteBio Octet platforms, ACROBiosystems provides biopharmaceutical R&D customers with complementary molecular interaction analysis services, including antibody screening, characterization, consistency evaluation, and biomolecule interactions that contribute to therapeutics development.</p></li></ul></div></div><div class="layui-col-md6" style="padding-top:10px !important;"><div class="div_content"><div class="content_left"><img src="/static/main/images/adc/adc_new_29.jpg" alt="Anti-Idiotypic Antibody Development Service" title="Anti-Idiotypic Antibody Development Service"/></div><div class="content_right"><p><a style="color:#cc3500;text-decoration: underline;" href="/A1320-Anti-Idiotypic-Antibody.html">Anti-Idiotypic Antibody Development Service</a></p><ol class=" list-paddingleft-2"><li><p><span>●</span> Fast response, one-on-one service</p></li><li><p><span>●</span> Ensure delivery of PK/ADA test kits with sensitivity</p></li><li><p><span>●</span> ACRO proteins supplied for free</p></li></ol></div><ul class=" list-paddingleft-2"><p class="content_title">Service</p><li><p>✔ Monoclonal/polyclonal anti-idiotype antibody, pharmacokinetic and immunogenicity test kit.</p></li><p class="content_title">Applications</p><li><p>✔ ADA assay: Perfect as Calibrator;</p></li><li><p>✔ PK assay: Quantitative analysis of therapeutic antibody in matrix.</p></li></ul></div></div></div></div></div><div class="clear"></div><p style="text-align:center;"><a target="_blank" href="/A2126-Free-Sample-Application-of-anti-payload-antibody.html"><img class="Promotion_box" src="/static/main/images/adc/adc_qs.gif" id="free"/></a></p></div><div class="clear"></div><div class="productSection"><div class="productTit">Product list</div><div class="layui-tab layui-tab-card" lay-filter="module"><ul class="layui-tab-title list-paddingleft-2"><li class="layui-this" lay-id="kit1" id="kit1"><p>ADC target proteins</p></li><li lay-id="kit2" id="kit2"><p>Proteases for peptide linker</p></li><li lay-id="kit4" id="kit4"><p>AGLink™ ADC site-specific conjugation kits</p></li><li lay-id="kit3" id="kit3"><p>Tools for ADCs PK analysis</p></li></ul><div class="layui-tab-content"><div class="layui-tab-item layui-show"><div class="productList"><a href="/L-266-Her2.html" class="normal_cf" target="_blank">Her2 <sup class="hot">HOT</sup></a><a href="/L-907-Nectin-4.html" class="normal_cf" target="_blank">Nectin-4 <sup class="hot">HOT</sup></a><a href="/L-480-TROP-2.html" class="normal_cf" target="_blank">TROP-2 <sup class="hot">HOT</sup></a><a href="/L-1103-LIV-1.html" class="normal_cf" target="_blank" style="background:#cc3536;opacity:80%; color:#FFF;"><strong style="color:#FFF;">LIV-1  <sup class="hot1">HOT NEW</sup></strong></a><a href="/L-432-ROR1.html" class="normal_cf" target="_blank" style="background:#cc3536;opacity:80%; color:#FFF !important;"><strong style="color:#FFF !important;">ROR1 <sup class="hot1">HOT NEW</sup></strong></a><a href="/L-373-Mesothelin.html" class="normal_cf" target="_blank">Mesothelin <sup class="hot">HOT</sup></a><a href="/L-913-CEACAM-5.html" class="normal_cf" target="_blank">CEACAM-5 <sup class="hot">HOT</sup></a><a href="/L-192-EGF R.html" class="normal_cf" target="_blank">EGF R <sup class="hot">HOT</sup></a><a href="/L-73-Siglec-2.html" class="normal_cf" target="_blank">Siglec-2 <sup class="hot">HOT</sup></a><a href="/L-87-Siglec-3.html" class="normal_cf" target="_blank">Siglec-3 <sup class="hot">HOT</sup></a><a href="/L-1023-GUCY2C.html" class="normal_cf" target="_blank">GUCY2C <sup class="hot">HOT</sup></a><a href="/L-201-ErbB3.html" class="normal_cf" target="_blank">ErbB3</a><a href="/L-231-FOLR1.html" class="normal_cf" target="_blank" style="background:#cc3536;opacity:80%; color:#FFF !important;"><strong style="color:#FFF;">FOLR1(FRα)<sup class="hot1">NEW</sup></strong></a><a href="/L-36-BCMA.html" class="normal_cf" target="_blank">BCMA <sup class="hot">HOT</sup></a><a href="/L-1101-Coagulation Factor III.html" class="normal_cf" target="_blank">Coagulation Factor III <sup class="hot">NEW</sup></a><a href="/L-1113-PTK7.html" class="normal_cf" target="_blank">PTK7 <sup class="hot">NEW</sup></a><a href="/L-1108-LY75.html" class="normal_cf" target="_blank">LY75 <sup class="hot">NEW</sup></a><a href="/L-1102-ENPP3.html" class="normal_cf" target="_blank">ENPP3 <sup class="hot">NEW</sup></a><a href="/L-1141-Claudin-18.2.html" class="normal_cf" target="_blank">Claudin-18.2 <sup class="hot">NEW</sup></a><a href="/L-492-TIM-1.html" class="normal_cf" target="_blank">TIM-1 <sup class="hot">NEW</sup></a><a href="/L-63-ALCAM.html" class="normal_cf" target="_blank">ALCAM</a><a href="/L-25-Axl.html" class="normal_cf" target="_blank">Axl</a><a href="/L-811-B7-H3.html" class="normal_cf" target="_blank">B7-H3</a><a href="/L-894-CA125.html" class="normal_cf" target="_blank">CA125</a><a href="/L-114-CD27%20Ligand.html" class="normal_cf" target="_blank">CD27 Ligand</a><a href="/L-69-CD19.html" class="normal_cf" target="_blank">CD19</a><a href="/L-80-CD30.html" class="normal_cf" target="_blank">CD30</a><a href="/L-90-CD37.html" class="normal_cf" target="_blank">CD37</a><a href="/L-99-CD46.html" class="normal_cf" target="_blank">CD46</a><a href="/L-101-CD48.html" class="normal_cf" target="_blank">CD48</a><a href="/L-117-CD74.html" class="normal_cf" target="_blank">CD74</a><a href="/L-118-CD79B.html" class="normal_cf" target="_blank">CD79B</a><a href="/L-889-DLL3.html" class="normal_cf" target="_blank">DLL3</a><a href="/L-968-EGFRvIII.html" class="normal_cf" target="_blank">EGFRvIII</a><a href="/L-195-EpCAM.html" class="normal_cf" target="_blank">EpCAM</a><a href="/L-963-Flt-3.html" class="normal_cf" target="_blank">Flt-3</a><a href="/L-142-HGF R.html" class="normal_cf" target="_blank">HGF R</a><a href="/L-284-IGF-I%20R.html" class="normal_cf" target="_blank">IGF-I R</a><a href="/L-317-IL-2%20R%20alpha.html" class="normal_cf" target="_blank">IL-2 R alpha</a><a href="/L-895-IL-3%20R%20alpha.html" class="normal_cf" target="_blank">IL-3 R alpha</a><a href="/L-1112-LRRC15.html" class="normal_cf" target="_blank" data-cl-id="3930078554">LRRC15 <strong></strong></a><a href="/L-1087-NCAM-1.html" class="normal_cf" target="_blank">NCAM-1</a><a href="/L-229-PSMA.html" class="normal_cf" target="_blank">PSMA</a><a href="/L-433-ROR2.html" class="normal_cf" target="_blank">ROR2</a><a href="/L-893-SLC1A5.html" class="normal_cf" target="_blank">SLC1A5</a><a href="/L-57-Syndecan-1.html" class="normal_cf" target="_blank">Syndecan-1</a><a href="/L-497-TNF-alpha.html" class="normal_cf" target="_blank">TNF-alpha</a><a href="/L-905-TPBG.html" class="normal_cf" target="_blank">TPBG</a><a href="/L-511-TRAIL%20R2.html" class="normal_cf" target="_blank">TRAIL R2</a><a href="/L-115-Transferrin%20R.html" class="normal_cf" target="_blank">Transferrin R</a></div></div><div class="layui-tab-item"><table class="public_table layui-table pro_table" style="border:1px #CCC solid;"><thead><tr class="firstRow"><th style="width: 15%;text-align: center">Molecule</th><th style="width:15%">Cat. No.</th><th class="pro_desc">Product Description</th><th style="width: 10%">Preorder/Order</th></tr></thead><tbody id="auto_linker_product_list"></tbody></table></div><div class="layui-tab-item"><table class="public_table layui-table pro_table"><thead><tr class="firstRow"><th style="width: 15%;text-align: center">Molecule</th><th style="width:15%">Cat. No.</th><th class="pro_desc">Product Description</th><th style="width: 10%">Preorder/Order</th></tr></thead><tbody id="auto_adc_product_list"></tbody></table></div><div class="layui-tab-item"><h3 style="font-weight: bold">> Anti-Payload antibody</h3><table class="public_table layui-table pro_table"><thead><tr class="firstRow"><th style="width: 15%;text-align: center">Molecule</th><th style="width:15%">Cat. No.</th><th class="pro_desc">Product Description</th><th style="width: 10%">Preorder/Order</th></tr></thead><tbody id="auto_pk_product_list"></tbody></table><h3 style="font-weight: bold">> Anti-Idiotypic Antibody</h3><table class="public_table layui-table pro_table"><thead><tr class="firstRow"><th>Molecule</th><th>Cat. No.</th><th>Product Description</th><th>Neutralizing activity</th><th>Application</th></tr></thead><tbody><tr><td>Adalimu*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2751-Anti-Adalimu*ab-Antibodies-%28AY19%29.html" target="_blank">ADB-Y19</a></td><td>Anti-Adalimu*ab Antibodies (AY19)</td><td>Neutralizing Antibody</td><td>ADA assay; Neutralizing assay; Indirect ELISA</td></tr><tr><td>Bevacizu*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2953-Anti-Bevacizu*ab-Antibodies-%28AY10%29-%28MALS-verified-recommended-for-PKPD%29.html" target="_blank">BEB-Y10</a></td><td>Anti-Bevacizu*ab Antibodies (AY10) (MALS verified, recommended for PK/PD)</td><td>Neutralizing Antibody</td><td>PK bridging ELISA; Neutralizing assay; Indirect ELISA</td></tr><tr><td>Bevacizu*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2770-Anti-Bevacizu*ab-Antibodies-%28AY12%29-%28recommended-for-neutralizing-assay%29.html" target="_blank">BEB-Y12</a></td><td>Anti-Bevacizu*ab Antibodies (AY12) (recommended for neutralizing assay)</td><td>Neutralizing Antibody</td><td>ADA assay; Neutralizing assay; Indirect ELISA</td></tr><tr><td>Bevacizu*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2771-Anti-Bevacizu*ab-Antibodies-%28AY9%29-%28recommended-for-ADA-assay%29.html" target="_blank">BEB-Y9</a></td><td>Anti-Bevacizu*ab Antibodies (AY9) (recommended for ADA assay)</td><td>Neutralizing Antibody</td><td>ADA assay; Neutralizing assay; Indirect ELISA</td></tr><tr><td>Bevacizu*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2952-Biotinylated-Anti-Bevacizu*ab-Antibodies-%28AY13%29-%28recommended-for-PKPD%29.html" target="_blank">BEB-BY13</a></td><td>Biotinylated Anti-Bevacizu*ab Antibodies (AY13) (recommended for PK/PD)</td><td>Neutralizing Antibody</td><td>PK bridging ELISA;Neutralizing assay; Indirect ELISA</td></tr><tr><td>Cetuxi*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2820-Anti-Cetuxi*ab-Antibodies-%28AY27%29-%28recommended-for-ADA-assay%29.html" target="_blank">CEB-Y27</a></td><td>Anti-Cetuxi*ab Antibodies (AY27) (recommended for ADA assay)</td><td>Neutralizing Antibody</td><td>ADA assay; Neutralizing assay; Indirect ELISA</td></tr><tr><td>Cetuxi*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2782-Anti-Cetuxi*ab-Antibodies-%28AY31%29-%28Non-Neutralizing%29.html" target="_blank">CEB-Y31</a></td><td>Anti-Cetuxi*ab Antibodies (AY31) (Non-Neutralizing)</td><td>Non-Neutralizing Antibody</td><td>ADA assay; Indirect ELISA</td></tr><tr><td>Cetuxi*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2747-Anti-Cetuxi*ab-Antibodies-%28AY28%29.html" target="_blank">CEB-Y28</a></td><td>Anti-Cetuxi*ab Antibodies (AY28)</td><td>Neutralizing Antibody</td><td>ADA assay; Neutralizing assay; Indirect ELISA</td></tr><tr><td>Cetuxi*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2911-Biotinylated-Anti-Cetuxi*ab-Antibodies-%28AY31%29-%28recommended-for-PKPD%29.html" target="_blank">CEB-BY31</a></td><td>Biotinylated Anti-Cetuxi*ab Antibodies (AY31) (recommended for PK/PD)</td><td>Non-Neutralizing Antibody</td><td>PK bridging ELISA; Indirect ELISA</td></tr><tr><td>Rituxi*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2815-Anti-Rituxi*ab-Antibodies-%28AY36%29-%28recommended-for-ADA-assay%29.html" target="_blank">RIB-Y36</a></td><td>Anti-Rituxi*ab Antibodies (AY36) (recommended for ADA assay)</td><td>Neutralizing Antibody</td><td>ADA assay;Neutralizing assay; Indirect ELISA</td></tr><tr><td>Rituxi*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2814-Anti-Rituxi*ab-Antibodies-%28AY37%29-%28recommended-for-PKPD%29.html" target="_blank">RIB-Y37</a></td><td>Anti-Rituxi*ab Antibodies (AY37) (recommended for PK/PD)</td><td>Neutralizing Antibody</td><td>PK bridging ELISA;Neutralizing assay;Indirect ELISA</td></tr><tr><td>Trastuzu*ab</td><td><a style="color:#cc3504;text-decoration: underline;" href="/P2999-Anti-Trastuzu*ab-Antibodies-%28AY5b%29-%28recommended-for-PKPD%29.html" target="_blank">TRB-Y5b</a></td><td>Anti-Trastuzu*ab Antibodies (AY5b) (recommended for PK/PD)</td><td>Neutralizing Antibody</td><td>PK bridging ELISA</td></tr></tbody></table></div></div></div></div><div class="productSection" id="p3"><div class="productTit">High-quality ADC target proteins</div><div class="main_div_box"><div class="main_div"></div><a target="_blank" href="/L-480-TROP-2.html"><div class="TROP-2 fenzibg-bg div-img1">TROP-2</div></a><a target="_blank" href="/L-907-Nectin-4.html"><div class="Nectin-4 fenzibg-bg div-img1">Nectin-4</div></a><a target="_blank" href="/L-192-EGF R.html"><div class="EGFR fenzism-bg div-img">EGFR</div></a><a target="_blank" href="/L-266-Her2.html"><div class="Her2 fenzibg-bg div-img1">Her2</div></a><a target="_blank" href="/L-913-CEACAM-5.html"><div class="CEACAM-5 fenzism-bg div-img">CEACAM-5</div></a><a target="_blank" href="/L-118-CD79B.html"><div class="CD79B fenzibg-bg div-img1">CD79B</div></a><a target="_blank" href="/L-229-PSMA.html"><div class="PSMA fenzibg-bg div-img1">PSMA</div></a><a target="_blank" href="/L-1141-Claudin-18.2.html"><div class="Claudin18-2 fenzism-bg div-img">Claudin18.2</div></a><a target="_blank" href="/L-231-FOLR1.html"><div class="FOLR1 fenzism-bg div-img">FOLR1</div></a><a target="_blank" href="/L-87-Siglec-3.html"><div class="Siglec-3 fenzism-bg div-img">Siglec-3</div></a><a target="_blank" href="/L-36-BCMA.html"><div class="BCMA fenzism-bg div-img">BCMA</div></a><a target="_blank" href="/L-73-Siglec-2.html"><div class="Siglec-2 fenzism-bg div-img">Siglec-2</div></a><a target="_blank" href="/L-69-CD19.html"><div class="CD19 fenzism-bg div-img">CD19</div></a><a target="_blank" href="/L-80-CD30.html"><div class="CD30 fenzism-bg div-img">CD30</div></a><a target="_blank" href="/L-889-DLL3.html"><div class="DLL3 fenzism-bg div-img">DLL3</div></a><a target="_blank" href="/L-1113-PTK7.html"><div class="PTK7 fenzismer-bg div-img">PTK7</div></a><a target="_blank" href="/L-1101-Coagulation Factor III.html"><div class="Coagulation fenzismer-bghot div-img1">TF</div></a><a target="_blank" href="/L-1101-Coagulation Factor III.html"><div class="Coagulation1 fenzibg-bg div-img1">TF</div></a><a target="_blank" href="/L-432-ROR1.html"><div class="ROR1 fenzismer-bghot div-img1">ROR1</div></a><a target="_blank" href="/L-1102-ENPP3.html"><div class="ENPP3 fenzismer-bg div-img">ENPP3</div></a><a target="_blank" href="/L-1103-LIV-1.html"><div class="LIV-1 fenzismer-bghot div-img1">LIV-1</div></a><a target="_blank" href="/L-142-HGF R.html"><div class="HGFR fenzismer-bg div-img">HGFR</div></a><a target="_blank" href="/L-1087-NCAM-1.html"><div class="NCAM-1 fenzismer-bg div-img">NCAM-1</div></a><a target="_blank" href="/L-968-EGFRvIII.html"><div class="EGFRvIII fenzismer1-bg div-img">EGFRvIII</div></a><a target="_blank" href="/L-985-CD133.html"><div class="CD133 fenzismer1-bg div-img">CD133</div></a><a target="_blank" href="/L-1108-LY75.html"><div class="LY75 fenzismer1-bg div-img">LY75</div></a></div><h3 class="h3-title">Case study</h3><div class="cd20ProtocolTitle"><div class="h4-title">High purity verified by MALS</div></div><div class="public_img_text_box public_img_l_r layui-col-space10"><div class="layui-col-md12" style="text-align:center !important;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_1.jpg" alt="HER2, MALS-validated protein" title="HER2, MALS-validated protein" style="height:260px;"/></div><p class="imgText" style="text-align:center;"><em>The purity of Human Her2, His Tag (Cat. No. <a href="/P109-Human-Her2--ErbB2-Protein-His-Tag-%28MALS-verified%29.html" target="_blank" data-cl-id="417892455">HE2-H5225</a>) was more than 90% and the molecular weight of this protein is around 80-95 kDa verified by SEC-MALS.</em></p></div></div><div class="clear"></div><div class="cd20ProtocolTitle"><div class="h4-title">High affinity validated by ELISA</div></div><div class="clear"></div><div class="public_img_text_box public_img_l_r layui-col-space10" style="float:left;"><div class="layui-col-md6" style="padding:20px;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_2.jpg" alt="HER2 protein's affinity verified by ELISA" title="HER2 protein's affinity verified by ELISA"/></div><p class="imgText"><em>Immobilized Human TROP-2, His Tag (Cat. No. <a target="_blank" href="/P2497-Human-TROP-2--TACSTD2-Protein-His-Tag-(MALS-verified).html">TR2-H5223</a>) at 1 μg/mL (100 μL/well) can bind Mouse Monoclonal Antibody Against Human TROP-2, Mouse IgG1 with a linear range of 0.1-2 ng/mL (QC tested).</em></p><center><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="TR2-H5223">Protocol</a></label></center></div><div class="layui-col-md6" style="padding:20px;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_3.jpg" alt="PSMA protein's affinity verified by ELISA" title="PSMA protein's affinity verified by ELISA"/></div><p class="imgText"><em>Immobilized Human PSMA, His Tag (Cat. No. <a target="_blank" href="/P2784-Human-PSMA--FOLH1-Protein-His-Tag-%28active-enzyme-MALS-verified%29.html" data-cl-id="3758932420">PSA-H52H3</a>) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human PSMA Antibody, Human IgG1 with a linear range of 0.3-39 ng/mL (Routinely tested).</em></p><center><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="PSA-H52H3">Protocol</a></label></center></div></div><div class="clear"></div><div class="cd20ProtocolTitle"><div class="h4-title">High affinity validated by SPR</div></div><div class="clear"></div><div class="public_img_text_box layui-col-space10" style="float:left;"><div class="layui-col-md6" style="padding:20px;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_4.jpg" alt="LIV-1 protein's affinity verified by SPR" title="LIV-1 protein's affinity verified by SPR"/></div><p class="imgText"><em>Anti-LIV-1 mAb captured on CM5 chip via anti-human IgG Fc antibody can bind Human LIV-1, His Tag (Cat. No. <a href="/P3542-Human-LIV-1--SLC39A6-Protein-His-Tag.html" target="_blank" data-cl-id="196872307">LV1-H5223</a>) with an affinity constant of 5.24 nM as determined in a SPR assay (Biacore T200) (Routinely tested).</em></p><center><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="LV1-H5223">Protocol</a></label><label class="btn_protocol" style="margin-right: 50px;float: right;width: 200px;"><a style="color:#FFFFFF" href="/A1151-SPR-BLI-analytical-service.html#services">Click to consult SPR service </a></label></center></div><div class="layui-col-md6" style="padding:20px;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_5.jpg" alt="HER2 protein's affinity verified by SPR" title="HER2 protein's affinity verified by SPR"/></div><p class="imgText"><em>Trastuz*mab captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human Her2, His Tag (Cat. No. <a href="/P109-Human-Her2--ErbB2-Protein-His-Tag-%28MALS-verified%29.html" target="_blank" data-cl-id="417892455">HE2-H5225</a>) with an affinity constant of 1.07 nM as determined in a SPR assay.<br/><br/></em></p><center><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="LV1-H5223">Protocol</a></label><label class="btn_protocol" style="margin-right: 50px;float: right;width: 200px;"><a style="color:#FFFFFF" href="/A1151-SPR-BLI-analytical-service.html#services">Click to consult SPR service</a></label></center></div></div><div class="public_img_text_box layui-col-space10" style="float:left;"><div class="layui-col-md6" style="padding:20px;"><div class="cd20ProtocolTitle"><div class="h4-title">High affinity validated by BLI</div></div><div class="clear"></div><div class="imgBox"><img src="/static/main/images/adc/adc_new_6.jpg" alt="Nectin-4 protein's affinity verified by BLI" title="Nectin-4 protein's affinity verified by BLI"/></div><p class="imgText"><em>Loaded Mouse Nectin-4, His Tag (Cat. No. <a target="_blank" href="/P3011-Mouse-Nectin-4-Protein-His-Tag.html" data-cl-id="1127955112">NE4-M52H3</a>) on HIS1K Biosensor, can bind Human Nectin-1, Fc Tag (Cat. No. <a href="/P3015-Human-Nectin-1--PVRL1--CD111-Protein-Fc-Tag.html" target="_blank" data-cl-id="1563684852">PV1-H5253</a>) with an affinity constant of 0.12 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).<br/><br/></em></p><center><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="LV1-H5223">Protocol</a></label><label class="btn_protocol" style="margin-right: 50px;float: right;width: 200px;"><a style="color:#FFFFFF" href="/A1151-SPR-BLI-analytical-service.html#services">Click to consult BLI service</a></label></center></div><div class="layui-col-md6" style="padding:20px;"><div class="cd20ProtocolTitle"><div class="h4-title">High affinity validated by FACS</div></div><div class="clear"></div><div class="imgBox"><img src="/static/main/images/adc/adc_new_7.jpg" alt="ROR1 protein's affinity verified by BLI" title="ROR1 protein's affinity verified by BLI"/></div><p class="imgText"><em>2e5 of anti-ROR1 CAR-293 cells were stained with 100 μL of 10 μg/mL of Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain), His Tag (Cat. No. <a href="/P2049-Human--Cynomolgus--Rhesus-macaque-ROR1-%2839-151-Ig-like-domain%29-Protein-His-Tag.html" target="_blank" data-cl-id="3894059826">RO1-H5221</a>) and negative control protein respectively, washed and then followed by PE-anti-His Tag and analyzed with FACS (Routinely tested).</em></p><center id="p4"><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="HE2-H5225">Protocol</a></label></center></div></div></div><div class="clear"></div><div class="productSection"><div class="productTit">Proteases for peptide linker</div><div class="public_img_text_box layui-col-space10"><div class="layui-col-md8"><div class="public_text_dec" style="margin-top:10px;">In the design and development of ADC, linker affects the stability of ADCs in systematic circulation, the speed of lysosomal processing, etc. There are two main categories of ADC linkers in current ADC drugs, cleavable linkers, and non-cleavable linkers.</div><div class="public_text_dec">Peptide linker as a protease-sensitive cleavable linker, is used in most ADCs that are undergoing clinical testing.  In the design of peptide linker, it is necessary to consider the selection of a suitable protease for linker cleavage, such as: <a href="/search-molecule-377_378-keywords-%20MMP-w-mo377_mo378.html" style="color:#cc3500;text-decoration: underline;" target="_blank" data-cl-id="4270627738">MMPs</a>/<a href="/search-keywords-Cathepsin.html" style="color:#cc3500;text-decoration: underline;" target="_blank" data-cl-id="2434026626">Cathepsin</a>/ <a href="/L-415-PLAU.html" style="color:#cc3500;text-decoration: underline;" target="_blank" data-cl-id="3095789127">PLAU</a> <sup>[2]</sup>.</div><div class="public_text_dec">Thus, ACROBiosystems has developed a series of MMPs, Cathepsin and uPA protein products for cleavage of Linker.</div><div class="public_text_dec" style="width:100%; margin:0 auto; border-radius:10px; height:36px; text-align:center; font-size:14px; margin-top:20px; line-height:36px; font-weight:bold; border:2px dotted #fde7c9; color:#FFF; background:#cc3536;"><img style="margin:2px 10px -1px 5px" src="/static/main/images/timg.png"/>More anti-payload antibodies (Anti-Dxd antibody/Anti-SN-38 antibody/Anti-SN-38 antibody) are coming soon！</div></div><div class="layui-col-md4" style="text-align:center;"><img src="/static/main/images/adc/box_5.jpg" alt="Mechanisms of action of ADCs" title="Mechanisms of action of ADCs" style="width:400px; margin-top:0px !important;"/></div></div><div class="clear"></div><h3 class="h3-title">Case study</h3><table class="public_table layui-table pro_table"><tbody><tr class="firstRow"><td style="color: #fff; background:#cc3536; border-bottom:1px solid #FFF !important; font-weight:bold; text-align:center !important; ">Products</td><td colspan="2">Cat. No.<a target="_blank" style="color:#cc3509;text-decoration: underline;" href="/P456-Human-Cathepsin-B--CTSB-Protein-His-Tag-%28active-enzyme%29.html">CTB-H5222</a> Human Cathepsin B / CTSB Protein, His Tag (active enzyme)</td><td colspan="2">Cat. No.<a target="_blank" style="color:#cc3509;text-decoration: underline;" href="/P281-Human-MMP-9-Protein-His-Tag-%28active-enzyme%29.html">MM9-H5221</a> Human MMP-9 Protein, His Tag (active enzyme)</td></tr><tr><td style="color: #fff; background:#cc3536; border-bottom:1px solid #FFF !important; font-weight:bold; text-align:center !important;">Hydrolyzed substrate</td><td colspan="2">Fluorogenic peptide substrate Z-LR-AMC</td><td colspan="2">Fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2</td></tr><tr id="p7"><td style="color: #fff; background:#cc3536; font-weight:bold; text-align:center !important; ">Enzymatic activity <br/>（pmol/min/μg）</td><td colspan="2"><strong>> 2500</strong></td><td colspan="2"><strong>> 2500</strong></td></tr></tbody></table><div class="clear"></div></div><div class="productSection"><div class="productTit">ADC site-specific conjugation kits</div><div class="public_text_dec">Conjugation methods are generally divided into random conjugation and site-specific conjugation. Random conjugation can cause several problems, including suboptimal therapeutic index, narrower therapeutic windows, and poor stability. Site-specific conjugations are designed to overcome the heterogeneity observed with ADCs that use random conjugation to surface-exposed lysine residues or conjugation to interchain disulfide bonds. Site-specific conjugation can precisely control conjugation sites, producing a homogenous mixture that yields higher potency ADC’s.</div><div class="public_text_dec" style="text-align:center;"><img src="/static/main/images/adc/adc_new_301.jpg" alt="The characteristics of various conjugation methods applied for ADCs" title="The characteristics of various conjugation methods applied for ADCs"/><br/><em id="Promotions" style="font-size:13.18px; font-style:italic;">The characteristics of various conjugation methods applied for ADCs<sup>[3]</sup></em></div><div class="public_img_text_box layui-col-space10 " style="float:left; margin-bottom:20px; margin-top:40px;"><div class="layui-col-md8"><div class="public_text_dec row-4">AGLink <span style="font-weight:bold;">ADC site-specific conjugation kits</span> are co-developed by ACROBiosystems and Glyco-therapy Biotechnology Co., Ltd. based on the conjugation platform (YTConjuTM) owned by Glyco-therapy Biotechnology Co., Ltd.<sup>[4]</sup>. AGLink enables enzymatic modification of IgG Fc glycans that result in homogenous conjugates, which can be used for early scientific research of ADCs.    <br/><p style="text-align: center!important; margin-top:20px;"><span class="tab_btn_protocolA" style="float:none !important;display:block !important;"><a href="/A1208-Leave-a-message.html" target="_blank">Inquiry and order</a><img src="/static/main/images/gmp_cart/hand.png" style="width: 20px;margin-top: 18px;margin-left: -13px; float:right !important;"/></span></p></div></div><div class="layui-col-md4"><div class="public_text_dec row-4">Explore how site-specific enzymatic modification of IgG Fc glycans can trasform your ADC development.<br/> <p style="text-align: center!important;margin-top:20px;"><span class="tab_btn_protocolA" style="float:none !important;display:block !important;"><a href="/A1887-site-specific-conjugation.html" target="_blank">Download the vivid poster to learn more</a><img src="/static/main/images/gmp_cart/hand.png" style="width: 20px;margin-top: 18px;margin-left: -13px; float:right !important;"/></span></p></div></div></div><div class="clear"></div><h3 class="h3-title">Mechanism of conjugation</h3><div class="public_text_dec" style="margin-top:20px; margin-bottom:20px;">All monoclonal antibodies are glycosylated at (or around) asparagine 297 (N297). The inherent site specificity of Fc glycosylation makes the glycoengineering being recognized as a universal and efficient approach to synthesize homogeneous antibody conjugates. Schematic diagrams are as follows <sup>[4]</sup>：</div><div class="public_img_text_box layui-col-space10 " style="float:left; margin-bottom:20px;"><div class="layui-col-md6"><div class="characterDec"><div class="picTitle red"><img style="margin:-7px 10px -1px 5px" src="/static/main/images/adc/pentagram2.png"/>AGlink ADC Conjugation Kit (MMAE, DAR4)</div><div class="public_text_dec" style="text-align: center;margin-top:10px;"><img src="/static/main/images/adc/adc_new_21.jpg" alt="AGlink ADC Conjugation Kit (MMAE, DAR4)" title="AGlink ADC Conjugation Kit (MMAE, DAR4)" width="85%"/></div></div></div><div class="layui-col-md6"><div class="picTitle red"><img style="margin:-7px 10px -1px 5px" src="/static/main/images/adc/pentagram2.png"/>AGlink ADC Conjugation Kit (MMAE, DAR2)</div><div class="characterDec"><div class="public_text_dec" style="text-align: center; margin-top:10px;"><img src="/static/main/images/adc/adc_new_22.jpg" alt="AGlink ADC Conjugation Kit (MMAE, DAR2)" title="AGlink ADC Conjugation Kit (MMAE, DAR2)" width="85%"/></div></div></div></div><div class="clear"></div><h3 class="h3-title">Assay Data</h3><div class="public_img_text_box layui-col-space10 "><div class="layui-col-md4"><div class="cd20ProtocolTitle"><div class="h4-title">High homogeneity conjugated antibodies</div></div><div class="imgBox"><img src="/static/main/images/adc/adc_new_23.jpg" alt="HIC-HPLC analysis of MMAE ADCs (DAR 4 & DAR 2) " title="HIC-HPLC analysis of MMAE ADCs (DAR 4 & DAR 2) "/></div><p class="imgText" style="text-align:center;"><em>HIC-HPLC analysis of MMAE ADCs (DAR 4 & DAR 2) </em></p></div><div class="layui-col-md4"><div class="cd20ProtocolTitle"><div class="h4-title">Preserved immunoreactivity after conjugation</div></div><div class="imgBox"><img src="/static/main/images/adc/adc_new_24.jpg" alt="The analysis of the antigen-binding capacity of MMAE ADCs (DAR 4 & DAR 2)" title="The analysis of the antigen-binding capacity of MMAE ADCs (DAR 4 & DAR 2)"/></div><p class="imgText" style="text-align:center;"><em>The analysis of the antigen-binding capacity of MMAE ADCs (DAR 4 & DAR 2), the results showing that binding to the HER2 antigen unaffected by the AGLink conjugation</em></p></div><div class="layui-col-md4"><div class="cd20ProtocolTitle"><div class="h4-title">Consistency in the site-specific labeling process ensures mitigate the aggregation</div></div><div class="imgBox"><img src="/static/main/images/adc/adc_new_25.jpg" alt="Less than 5% of antibody aggregation by SEC-HPLC " title="Less than 5% of antibody aggregation by SEC-HPLC "/></div><p class="imgText" style="text-align:center;"><em>Less than 5% of antibody aggregation by SEC-HPLC </em></p></div></div><div class="public_img_text_box layui-col-space10 "><div class="layui-col-md12"><div class="cd20ProtocolTitle"><div class="h4-title">The conjugates have high in-vitro plasma stability</div></div><div class="clear"></div><div class="imgBox" style="text-align:center;"><img src="/static/main/images/adc/adc_new_26.jpg" height="260" alt="The conjugates have high in-vitro plasma stability" title="The conjugates have high in-vitro plasma stability"/></div><p class="imgText" style="text-align:center;"><em>MMAE ADCs (DAR 4 & DAR 2) are stable in human plasma in vitro </em></p></div></div><div class="public_img_text_box layui-col-space10 "><div class="layui-col-md12"><div class="cd20ProtocolTitle"><div class="h4-title">In-vitro cell-killing activity assay</div></div><div class="clear"></div><div class="imgBox" style="text-align:center;"><img src="/static/main/images/adc/adc_new_27.jpg" height="260" alt="In-vitro cell-killing activity assay " title="In-vitro cell-killing activity assay "/></div><p class="imgText" style="text-align:center;" id="p5"><em>Validated in-vitro cell-killing activity of MMAE ADCs (DAR 4 & DAR 2)</em></p></div></div><div class="clear"></div></div><div class="productSection"><div class="clear"></div><div class="layui-row"><div class="layui-collapse" lay-filter="test"><div class="layui-colla-item"><h2 class="layui-colla-title">FAQ</h2><div class="layui-colla-content layui-show"><p class="public_text_dec titleB" style="font-weight: bold;">1. What is the minimum required amount for small-scale reaction?</p><p class="public_text_dec titleB">The minimum amount is 200 μg. Although the dilution ratio is small, the volume of the reaction system will affect recovery because there are fixed losses during desalting processes.</p><p class="public_text_dec titleB" style="font-weight: bold; margin-top: 20px;">2. Is it necessary to achieve an antibody concentration of 1 mg/mL?</p><p class="public_text_dec titleB"> A concentration as low as 1 mg/mL can be used, but the reaction time may need to be extended up to 48 hours to obtain ideal DAR values due to larger reaction volumes and lower enzyme and payload concentrations.</p><p class="public_text_dec titleB" style="font-weight: bold; margin-top: 20px;">3. Are there any requirements for antibody species?</p><p class="public_text_dec titleB"> Humanized antibodies have no issues, but mouse and rabbit antibodies are more complex. Some antibodies may not couple easily, which can be resolved by extending the reaction time.</p><p class="public_text_dec titleB" style="font-weight: bold; margin-top: 20px;">4. Can it be used for large-scale production?</p><p class="public_text_dec titleB"> Customized services from g to G scale are available upon request.</p></div></div></div></div><div class="clear"></div><div class="productTit">PK analysis</div><div class="public_img_text_box layui-col-space12 molecular_box"><div class="layui-col-md12" style="float:left;"><div class="public_text_dec">Supporting Immunogenicity and PK analysis, ACRO provides series of <a style="color:#cc3509;text-decoration: underline;" href="/search-molecule-377_378-keywords-%20MMP-w-mo377_mo378.html">anti-MMAE antibodies</a> and <a style="color:#cc3509;text-decoration: underline;" href="/A1089-Anti-idiotypic-Antibodies.html" target="_blank">anti-idiotypic antibodies</a> with high affinity, high specificity and high sensitivity.</div><div class="characterDec"><div class="lf"><div class="characterDec"><span>Used for the positive reference of ADCs preclinical/clinical immunogenicity and PK analysis;</span><br/><span>Save customer's time to prepare antibodies;</span><br/><span>Complete methodology protocols are available freely.</span><br/></div></div></div></div></div><div class="clear"></div><h3 class="h3-title">Case study</h3><div class="public_img_text_box layui-col-space10" style="float:left;"><div class="clear"></div><div class="cd20ProtocolTitle"><div class="h4-title">PK assay: Anti-MMAE antibody binding MMAE with high specificity</div></div><div class="clear"></div><div class="layui-col-md6" style="padding:20px;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_8.jpg" alt="Anti-MMAE antibody binding MMAE with high specificity" title="Anti-MMAE antibody binding MMAE with high specificity"/></div><p class="imgText"><em>The EC50 value of anti-MMAE antibody to MMAE-conjugated hRS7 (MMAE-ADC) was 0.12 μg/ml. The unconjugated hRS7 antibody was used as negative control</em></p></div><div class="layui-col-md6" style="padding:20px;"><div class="imgBox"><img src="/static/main/images/adc/adc_new_9.jpg" alt="Anti-MMAE antibody binding MMAE-ADC with high specificity" title="Anti-MMAE antibody binding MMAE-ADC with high specificity"/></div><p class="imgText"><em>Immobilized Disitamab Vedotin (RC48) at 0.2 μg/mL (100 μL/well) can bind Mouse Anti-MMAE Antibody, Mouse IgG1 (Cat. No. <a style="color:#cc3500;text-decoration: underline;" href="/P4326-Mouse-Anti-MMAE-Antibody-Mouse-IgG1-%28MALS-verified%29.html" target="_blank">MME-M5252</a>) with a linear range of 0.1-2 ng/mL (QC tested).</em></p><center><label class="btn_protocol des_protocol" style="margin-right: 20px;"><a style="color:#FFFFFF" data-sign="MME-M5252">Protocol</a></label></center></div></div><div class="clear"></div><div class="cd20ProtocolTitle"><div class="h4-title">PK assay: Specific detection of antibody drug levels in the body</div></div><div class="clear"></div><div class="public_img_text_box public_img_s layui-col-space12" style="float:left;"><div class="layui-col-md4"><div class="imgBox"><img src="/static/main/images/service_ada/ada_8.png" alt="PK assay for ADCs: Specific detection of antibody drug levels in the body" title="PK assay for ADCs: Specific detection of antibody drug levels in the body" style="width:90% !important;"/></div><div class="img_content" style="text-align:center">Detection of Ritux*mab by antigen-capture ELISA (0.1% serum).</div></div><div class="layui-col-md4"><div class="imgBox"><img src="/static/main/images/service_ada/ada_9.png" alt="PK assay for ADCs: Specific detection of antibody drug levels in the body" title="PK assay for ADCs: Specific detection of antibody drug levels in the body" style="width:90% !important;"/></div><div class="img_content" style="text-align:center">Detection of Ritux*mab by anti-idiotypic capture ELISA (0.1% serum).</div></div><div class="layui-col-md4"><div class="imgBox"><img src="/static/main/images/service_ada/ada_10.png" alt="PK assay for ADCs: Specific detection of antibody drug levels in the body" title="PK assay for ADCs: Specific detection of antibody drug levels in the body" style="width:90% !important;"/></div><div class="img_content" style="text-align:center">Detection of Ritux*mab by anti-idiotypic bridging ELISA (10% serum).</div></div></div><div class="product-div"><center><table class="public_table layui-table pro_table" style="border:1px #CCC solid;"><thead><tr class="firstRow"><th>Method</th><th>Coated</th><th>Sample</th><th width="20%">Linear range<br/>(µg/mL)</th><th width="20%">Sensitivity<br/>(µg/mL)</th><th>Advantage</th></tr></thead><tbody><tr><td style="text-align: left">Antigen capture ELISA</td><td style="text-align: left">CD20</td><td style="text-align: left">Goat anti-human IgG</td><td>—</td><td>—</td><td style="text-align: left">Simple and universal method</td></tr><tr><td style="text-align: left">Anti-idiotypic capture ELISA</td><td style="text-align: left">Anti-Ritux*mab Antibodies</td><td style="text-align: left">Goat anti-human IgG</td><td>0.156-10</td><td>0.156</td><td style="text-align: left">It is a simple method for extracting CD20</td></tr><tr><td style="text-align: left">Bridging ELISA by anti-idiotypic antibodies</td><td style="text-align: left">Anti-Ritux*mab Antibodies</td><td style="text-align: left">Biotinylated Anti-Ritux*mab Antibodies</td><td>0.012-0.78</td><td>0.012</td><td style="text-align: left">CD20 can be obtained with good sensitivity and low background noise</td></tr></tbody></table><div class="public_text_dec" id="p6">Comparison between anti-idiotypic capture ELISA and anti-idiotypic bridging elisa for Ritux*mab detection in patient samples</div></center></div><div class="clear"></div></div><div class="productSection"><div class="productTit">SPR/BLI analytical service & Anti-idiotypic antibody development service</div><div class="public_text_dec">In addition, relying on a very capable and highly professional team, ACROBiosystems also provides customers with high-quality integrated SPR&BLI analytical service and one-stop services about monoclonal/polyclonal anti-idiotype antibody, facilitating your ADCs development.</div><div class="public_img_text_box layui-col-space10 " style="float:left; margin-bottom:20px;"><div class="layui-col-md6"><div class="characterDec"><div class="picTitle red"><img style="margin:-7px 10px -1px 5px" src="/static/main/images/adc/pentagram2.png"/>SPR/BLI analytical service</div><div class="lf" style="margin-left:20px; margin-top:20px;"><div class="characterDec"><span>Cooperated with hundreds of industrial and scientific research users;</span><br/><span>Proteins offered for free;</span><br/><span>High standard quality management control system;</span><br/><span>Next day reports at the earliest;</span><br/><span>Support more than 300 drugs until clinical applications.</span></div></div><div class="public_text_dec" style="text-align: left;"><img src="/static/main/images/adc/box_6.jpg" alt="SPR/BLI analytical in ADCs" title="SPR/BLI analytical in ADCs" width="80%"/></div><div class="public_text_dec" style="text-align: center;text-align:center !important;"><span class="tab_btn_protocol" style="float:none !important;width:130px;display:block !important;margin:0 auto;"><a href="/A1151-SPR-BLI-analytical-service.html#services" target="_blank" style="color:#FFF;text-decoration: none;">Contact us</a> </span></div></div></div><div class="layui-col-md6"><div class="picTitle red"><img style="margin:-7px 10px -1px 5px" src="/static/main/images/adc/pentagram2.png"/>Anti-idiotypic antibody development service</div><div class="characterDec"><div class="lf" style="margin-left:20px; margin-top:20px;"><div class="characterDec"><span>ACRO proteins supplied for free;</span><br/><span>Quick response, one-to-one service from the project team, real-time follow-up;</span><br/><span>Provide one-stop service from antigen preparation to detection kit development;</span><br/><span>Guaranteed delivery of PK/ADA detection reagents whose sensitivity meets regulatory requirements.</span></div></div><div class="public_text_dec" style="text-align: left;"><img src="/static/main/images/adc/box_7.jpg" alt="Anti-idiotypic antibody development service in ADCs" title="Anti-idiotypic antibody development service in ADCs" width="80%"/></div><div class="public_text_dec" style="text-align: center; text-align:center !important;"><span style="float:none !important; width:130px; display:block !important; margin:0 auto;" class="tab_btn_protocol"><a href="/A1321-ADA-Development-Service-Inquiry.html" target="_blank" style="color:#FFF;text-decoration: none;">Contact us</a> </span></div></div></div></div><div class="clear"></div><h3 class="h3-title">References</h3><div class="citationBox"><div class="box current"><h3><span class="yuan1"></span> <span class="yuan2"></span>[1]Criscitiello C, et al. Antibody-drug conjugates in solid tumors: a look into novel targets. J Hematol Oncol. 2021 Jan 28;14(1):20.</h3></div></div><div class="citationBox"><div class="box current" style="margin-top: 10px"><h3><span class="yuan1"></span> <span class="yuan2"></span>[2]Poreba M. Protease-activated prodrugs: strategies, challenges, and future directions. FEBS J. 2020 May;287(10):1936-1969.</h3></div></div><div class="citationBox"><div class="box current" style="margin-top: 10px"><h3><span class="yuan1"></span> <span class="yuan2"></span>[3] Antibody drug conjugate: the “biological missile” for targeted cancer therapy</h3></div></div><div class="citationBox"><div class="box current" style="margin-top: 10px"><h3><span class="yuan1"></span> <span class="yuan2"></span>[4] Reducing the Complexity of Fc Glycan Enables the Construction of Antibody Conjugates with Unexpected High Efficiency and Payload Capacity via Glycoengineering</h3></div></div></div><div class="clear"></div></div></div><style>.footer_kf { height:100px; width:100%; position:fixed; bottom:0; left:0; z-index:8888;} .fd_box { height:120px; position:fixed; width:100%; bottom:0; left:0; z-index:666;} .fd_box01 { width:100%; height:99px; position:fixed; bottom:0;background:-webkit-linear-gradient(to right,#fa429f 50%,#00f76d 50%); background:linear-gradient(to right,#fa429f 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'other' : huiju_tag; var url = window.location.pathname; var url_arr = url.match(/\/([A|L][0-9]{1,10})-/); huiju_tag = url_arr != null ? url_arr[1] : huiju_tag; try{ clab_tracker.ready(function(){ const s = { source: getCookie("zfx_utm_source"), source1: getCookie('zfx_utm_medium'), source8: getCookie('zfx_utm_term'), contentName: getCookie('zfx_utm_content'), source7: getCookie('zfx_utm_campaign') }; this.push(s); if(Request.cid) this.push({customerId: Request.cid}); this.push({"pageType":"web"}); this.track("open_page", { tag: huiju_tag, identityType: 'email', identityValue: $("#auto_user_email").val() }); }); } catch (e) { var clab_tracker = {push: function() {}, track: function() {}} } function getFormatDate(){ var nowDate = new Date(); var year = nowDate.getFullYear(); var month = nowDate.getMonth() + 1 < 10 ? "0" + (nowDate.getMonth() + 1) : nowDate.getMonth() + 1; var date = nowDate.getDate() < 10 ? 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