SU 5416 (CAS 204005-46-9): R&D Systems

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class="ds_title">SU 5416 </h1> <div class="dsSprite_tocris ds_brand_logo ds_tocris_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: 3037</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 12 Citations </a> </span> <span class="reviews review_stars_5"> <a href="#product-reviews" id="product_reviews" class="jump_to" data-tab="6" data-tabname="product-reviews"> 1 Review </a> </span> <a href="/reviews/3037" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/su-5416_3037" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">     <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="3037/10"> <td class="dat_catalog_column">3037/10</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-30372f10 form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-30372f10" name="catnum-3037%2F10" value="" size="5" maxlength="3" /></div></td> </tr> <tr class="et_atc_product" data-sku="3037/50"> <td class="dat_catalog_column">3037/50</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div 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No. 3037 - SU 5416" href="https://resources.rndsystems.com/images/datasheets/structures/su-5416_3037.png"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/structures/su-5416_3037.png" class="img-fluid" alt="SU 5416 | CAS No. 204005-46-9 | VEGF Receptor Inhibitors" title="SU 5416 | CAS No. 204005-46-9 | VEGF Receptor Inhibitors"> </a> <div class="search_image_other_count"> <span class="search_more_images">1 Image</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> </div> </div> <div class="product_info_wrapper"> <div class="product_info"> <strong>Description:</strong> VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 </div> <div class="product_info"> <strong>Alternative Names: </strong> Semaxinib </div> <p class="extended_details_chemical_name"> <strong>Chemical Name:</strong> 3-[(3,5-Dimethyl-1<em>H</em>-pyrrol-2-yl)methylene]-1,3-dihydro-2<em>H</em>-indol-2-one </p> <p class="extended_details_purity"> <strong>Purity:</strong> ≥99%</p> </div> <div id="view-more-target" class="datasheet_section_element"> View <a href="/target/vegf-receptor-inhibitors">All Products for VEGF Receptor Inhibitors</a> </div> </div> <div class="tabbed_content" id="rnd_tocris"> <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (12)</span> </div> <div class="tab tab_5" data-tab="5" data-tabname="supplemental-products" id="dsTabs_supplemental-products"> <span>Supplemental Products</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews (1) </span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_biological_activity" id="product-anchor-ds_biological_activity">Biological Activity</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_technical_data" id="product-anchor-ds_technical_data"> Technical Data</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets"> Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_calculator" id="product-anchor-ds_calculator">Calculators</a> </div> <div id="ds_biological_activity" class="datasheet_section"> <h2>Biological Activity</h2> SU 5416, an angiogenesis inhibitor, is a potent vascular endothelial growth factor receptor tyrosine kinase 1/2 inhibitor (IC<sub>50</sub> = 40 nM). SU 5416 also potently inhibits c-Kit, FLT3 and RET tyrosine kinases (IC<sub>50</sub> values are 30 nM, 160 nM and 170 nM, respectively). SU 5416 shows inhibition of tumour growth and vascularization and can be used to generate an animal model of pulmonary arterial hypertension. </div> <div id="ds_technical_data" class="datasheet_section"> <h2>Technical Data</h2> <div class="ds_table summary_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">M.Wt:</div> <div class="ds_table_cell summary_table_data">238.28</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Formula:</div> <div class="ds_table_cell summary_table_data">C<sub>15</sub>H<sub>14</sub>N<sub>2</sub>O</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Solubility:</div> <div class="ds_table_cell summary_table_data">Soluble to 100 mM in DMSO</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Purity:</div> <div class="ds_table_cell summary_table_data">≥99%</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Storage:</div> <div class="ds_table_cell summary_table_data">Desiccate at -20°C</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">CAS No:</div> <div class="ds_table_cell summary_table_data">204005-46-9</div> </div> </div> </div> <p class="small"> The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.<br/> Tocris products are intended for laboratory research use only, unless stated otherwise. </p> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="3037"></div> <div id="ds_background" class="datasheet_section"> <h2>Background References</h2> <ol class="tocris_background_refs"> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/27441378" target="_blank" rel="noreferrer nofollow" class="safe_link"> Slug Is Increased in Vascular Remodeling and Induces a Smooth Muscle Cell Proliferative Phenotype </a> <br/> <br/> PLoS ONE, 2016;11(7):e0159460. </li> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/25018103" target="_blank" rel="noreferrer nofollow" class="safe_link"> Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. </a> <br/> Yuen T, Silbereis J, Griveau A, Chang S, Daneman R, Fancy S, Zahed H, Maltepe E, Rowitch D<br/> Cell, 2014;158(2):383-96. </li> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/24657995" target="_blank" rel="noreferrer nofollow" class="safe_link"> Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension. </a> <br/> Lavoie J, Ormiston M, Perez-Iratxeta C, Courtman D, Jiang B, Ferrer E, Caruso P, Southwood M, Foster W, Morrell N, Stewart D<br/> Circulation, 2014;129(21):2125-35. </li> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/24885283" target="_blank" rel="noreferrer nofollow" class="safe_link"> Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum. </a> <br/> Hempel C, Hoyer N, Staalso T, Kurtzhals J<br/> Malar J, 2014;13(0):201. </li> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/9892193" target="_blank" rel="noreferrer nofollow" class="safe_link"> SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularisation, and growth of multiple tumor types. </a> <br/> Fong et al.<br/> Cancer Res., 1999;59:99 </li> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/11222388" target="_blank" rel="noreferrer nofollow" class="safe_link"> The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-Kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. </a> <br/> Smolich et al.<br/> Blood, 2001;97:1413 </li> <li> <a href="http://www.ncbi.nlm.nih.gov/pubmed/17032739" target="_blank" rel="noreferrer nofollow" class="safe_link"> Inhibition of RET tyrosine kinase by SU5416. </a> <br/> Mologni et al.<br/> J.Mol.Endocrinol., 2006;37:199 </li> </ol> </div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets tocris_docs" id="product-datasheets"> <div class="row"> <div class="col-sm-12 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id="btn_reconstitution_calc" class="datasheet_calculator"><h2>Reconstitution Calculator</h2><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div><div id="btn_molarity_calc" class="datasheet_calculator"><h2>Molarity Calculator</h2><div class="molarity_framework"> <div id="molarity_calculator" class="calculator"> <form id="molCalc"> <div class="calc_section"> <label for="molarity_calculator_mass" class="calculator_label">Mass</label> <input id="molarity_calculator_mass" name="molarity_calculator_mass" type="text" maxlength="6" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="molarity_calculator_mass_unit" class="calculator_input calculator_select" name="molarity_calculator_mass_unit"> <option value="-12">picograms</option> <option value="-9">nanograms</option> <option value="-6">micrograms</option> <option value="-3" selected>milligrams</option> <option value="0">grams</option> <option value="3">kilograms</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="molarity_calculator_concentration" class="calculator_label">Concentration</label> <input id="molarity_calculator_concentration" name="molarity_calculator_concentration" type="text" maxlength="6" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="molarity_calculator_concentration_unit" class="calculator_input calculator_select" name="molarity_calculator_concentration_unit"> <option value="-15">femtomolar</option> <option value="-12">picomolar</option> <option value="-9">nanomolar</option> <option value="-6">micromolar</option> <option value="-3" selected>millimolar</option> <option value="0">molar</option> </select> </span> </div> <span class="calculator_multiply calculator_operator">x</span> <div class="calc_section"> <label for="molarity_calculator_volume" class="calculator_label">Volume</label> <input id="molarity_calculator_volume" name="molarity_calculator_volume" type="text" maxlength="6" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="molarity_calculator_volume_unit" class="calculator_input calculator_select" name="molarity_calculator_volume_unit"> <option value="-9">nanoliter</option> <option value="-6">microliter</option> <option value="-3" Selected>milliliter</option> <option value="0">liter</option> </select> </span> </div> <span class="calculator_multiply calculator_operator">x</span> <div class="calc_section"> <label for="molarity_calculator_molecular_weight" class="calculator_label">M. Wt*</label> <input id="molarity_calculator_molecular_weight" name="molarity_calculator_molecular_weight" type="text" maxlength="6" placeholder="mwt" class="calculator_input calculator_text" value="238.28"/> <span class="calculator_unit_label">g/mol</span> </div> <div id="molarity_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_molarity_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> <div> <p>*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).</p> </div> </form> </div> </div> </div></div> </div> </div> <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for SU 5416</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> The citations listed below are publications that use Tocris products. Selected citations for SU 5416 include: </p> <p> <strong><span id="maxcitations">12</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">10</span> </strong> </p> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="12" data-max-show="10"> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/29570992"> Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. </a> </span><br/> Authors: Longchamp Et al.<br/> Cell  2018;173:117 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28084316"> TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. </a> </span><br/> Authors: Hurst<br/> Nat Commun  2017;8:14079 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28473439"> Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. </a> </span><br/> Authors: Meloche Et al.<br/> Arterioscler Thromb Vasc Biol  2017;37:1513 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28183533"> Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition. </a> </span><br/> Authors: Neto-Neves Et al.<br/> Am J Pathol  2017;187:700 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27036867"> Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats. </a> </span><br/> Authors: Happ&eacute Et al.<br/> Am J Physiol Lung Cell Mol Physiol  2016;310:L1088 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26635611"> Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma. </a> </span><br/> Authors: Azzi Et al.<br/> Pulm Circ  2015;6:281 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/26076038"> Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. </a> </span><br/> Authors: Long Et al.<br/> Nat Med  2015;21:777 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25006448"> Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. </a> </span><br/> Authors: Chabon Et al.<br/> J Neurophysiol  2014;4:289 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25320085"> KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling. </a> </span><br/> Authors: DiStefano Et al.<br/> J Biol Chem  2014;289:33054 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24885283"> Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum. </a> </span><br/> Authors: Hempel Et al.<br/> Malar J  2014;13:201 <br/> </li> <div id="ds_extra_cits"> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25425003"> Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition. </a> </span><br/> Authors: Cavasin Et al.<br/> J Transl Med  2014;12:314 <br/> </li> <li class="top-lined" data-species="" data-application="" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/20683208"> Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. </a> </span><br/> Authors: Novitskiy Et al.<br/> J Thorac Oncol  2010;5:1410 <br/> </li> </div> </ol> </div> <div class="clearfix"><button class="btn btn-quinary ds_extra_cits pull-right toggle_cits_down" id="toggle_cits"></button></div> </div> </div> <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <p>No product specific FAQs exist for this product, however you may</p> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/small-molecules"> View all Small Molecule FAQs </a> </div> </div> </div>  <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for SU 5416</h3> <div class="row"> <div class="col-xs-12"> <div class="datasheet_section"> <div class="row"> <div class="col-md-6"> <p> Average Rating: 5 <span class="review_stars_5"></span> (Based on 1 Review) </p> <div class="review_rating_progress"> <div class="row"> <div class="col-xs-3"> 5 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="100" aria-valuemin="0" aria-valuemax="100" style="width:100%"> </div> </div> </div> <div class="col-xs-3"> 100% </div> </div> <div class="row"> <div class="col-xs-3"> 4 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 3 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 2 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 1 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> </div> </div> <div class="col-md-6"> <div class="well"> <h4>Have you used SU 5416?</h4> <h5><strong>Submit a review and receive an Amazon gift card.</strong></h5> <div class="review_reward_txt"> <p>$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image</p> <p>$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image</p> </div> <a class="btn btn-quinary" href="/reviews/3037"> Submit a Review </a> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <div class="reviews_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper"> <select class="review_filter_rating"> <option value="all">All Ratings</option> <option value="5">5</option> </select> </div> <div class="select_wrapper"> <select class="review_filter_application"> <option value="all">All Applications</option> </select> </div> </div> </div> </div> <br/> <div class="review_row" data-rating="5" data-species="" data-application=""> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">SU5416</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 12/01/2017 </div> <div class="row"> <div class="review_specifics col-xs-12"> </div> </div> <div class="review_how_used"><p>We study rodent models of pulmonary hypertension where we inject SU5416 in addition to placing the animals in hypoxia to exacerbate the PH phenotype</p></div> </div> </div> <hr/> </div> </div> </div> <div class="Tocris_disclamer"> Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. 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SU 5416 (CAS 204005-46-9): R&D Systems