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multiple-unit tablets</title> <meta name="description" content="Search results for: multiple-unit tablets"> <meta name="keywords" content="multiple-unit tablets"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="multiple-unit tablets"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 149</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: multiple-unit tablets</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">149</span> Using iPads and Tablets in Language Teaching and Learning Process</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ece%20Sarigul">Ece Sarigul</a> </p> <p class="card-text"><strong>Abstract:</strong></p> It is an undeniable fact that, teachers need new strategies to communicate with students of the next generation and to shape enticing educational experiences for them. Many schools have launched iPad/ Tablets initiatives in an effort to enhance student learning. Despite their rapid adoption, the extent to which iPads / Tablets increase student engagement and learning is not well understood. This presentation aims to examine the use of iPads and Tablets in primary and high schools in Turkey as well as in the world to increase academic achievement through promotion of higher order thinking skills. In addition to explaining the ideas of school teachers and students who use the specific iPads or Tablets , various applications in schools and their use will be discussed and demonstrated in this study. The specific” iPads or Tablets” applications discussed in this presentation can be incorporated into the curriculum to assist in developing transformative practices and programs to meet the needs of a diverse student population. In the conclusion section of the presentation, there will be some suggestions for teachers about the effective use of technological devices in the classroom. This study can help educators understand better how students are currently using iPads and Tablets and shape future use. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ipads" title="ipads">ipads</a>, <a href="https://publications.waset.org/abstracts/search?q=language%20teaching" title=" language teaching"> language teaching</a>, <a href="https://publications.waset.org/abstracts/search?q=tablets" title=" tablets"> tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=technology" title=" technology"> technology</a> </p> <a href="https://publications.waset.org/abstracts/29873/using-ipads-and-tablets-in-language-teaching-and-learning-process" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29873.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">254</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">148</span> Sustained-Release Persulfate Tablets for Groundwater Remediation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yu-Chen%20Chang">Yu-Chen Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yen-Ping%20Peng"> Yen-Ping Peng</a>, <a href="https://publications.waset.org/abstracts/search?q=Wei-Yu%20Chen"> Wei-Yu Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ku-Fan%20Chen"> Ku-Fan Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Contamination of soil and groundwater has become a serious and widespread environmental problem. In this study, sustained-release persulfate tablets were developed using persulfate powder and a modified cellulose binder for organic-contaminated groundwater remediation. Conventional cement-based persulfate-releasing materials were also synthesized for the comparison. The main objectives of this study were to: (1) evaluate the release rates of the remedial tablets; (2) obtain the optimal formulas of the tablets; and (3) evaluate the effects of the tablets on the subsurface environment. The results of batch experiments show that the optimal parameter for the preparation of the persulfate-releasing tablet was persulfate:cellulose = 1:1 (wt:wt) with a 5,000 kg F/cm2 of pressure application. The cellulose-based persulfate tablet was able to release 2,030 mg/L of persulfate per day for 10 days. Compared to cement-based persulfate-releasing materials, the persulfate release rates of the cellulose-based persulfate tablets were much more stable. Moreover, since the tablets are soluble in water, no waste will be produced in the subsurface. The results of column tests show that groundwater flow would shorten the release time of the tablets. This study successfully developed unique persulfate tablets based on green remediation perspective. The efficacy of the persulfate-releasing tablets on the removal of organic pollutants needs to be further evaluated. The persulfate tablets are expected to be applied for site remediation in the future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sustained-release%20persulfate%20tablet" title="sustained-release persulfate tablet">sustained-release persulfate tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=modified%20cellulose" title=" modified cellulose"> modified cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=green%20remediation" title=" green remediation"> green remediation</a>, <a href="https://publications.waset.org/abstracts/search?q=groundwater" title=" groundwater"> groundwater</a> </p> <a href="https://publications.waset.org/abstracts/80243/sustained-release-persulfate-tablets-for-groundwater-remediation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80243.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">290</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">147</span> Formulation Development and Evaluation of Floating Tablets of Venlafaxine Hydrochloride</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gajera%20Lalit">Gajera Lalit</a>, <a href="https://publications.waset.org/abstracts/search?q=Shah%20Pranav"> Shah Pranav</a>, <a href="https://publications.waset.org/abstracts/search?q=Shah%20Shailesh"> Shah Shailesh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Venlafaxine hydrochloride has a short elimination half-life of 5 ± 2 hr, and absorption window in the upper part of gastrointestinal tract. The conventional tablets need to be administered two to three times a day and possess an oral bioavailability of 45%. The purpose of this study was to formulate gastroretentive effervescent floating tablets of Venlafaxine HCl. Different grades of HPMC namely K15M, K4M, K100M and E15LV were employed as swelling polymers whereas sodium bicarbonate was employed as gas generating agent. The direct compression method was employed for the formulation of tablets. The tablets were evaluated in terms of hardness, friability, weight variation, drug content, water uptake, in-vitro floating behavior and in-vitro drug release study. All the formulations exhibited very short floating lag time of < 1 min and total floating time of 12 hr. Formulation L3 containing 25 mg and 75 mg of HPMC E15 LV and HPMC K15M respectively exhibited complete drug release within 12 hrs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=venlafaxine%20HCl" title="venlafaxine HCl">venlafaxine HCl</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxyl%20propyl%20methylcellulose" title=" hydroxyl propyl methylcellulose"> hydroxyl propyl methylcellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=floating%20gastro%20retentive%20tablets" title=" floating gastro retentive tablets"> floating gastro retentive tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=in-vitro%20drug%20release" title=" in-vitro drug release"> in-vitro drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=non-fickian%20diffusion" title=" non-fickian diffusion"> non-fickian diffusion</a> </p> <a href="https://publications.waset.org/abstracts/16234/formulation-development-and-evaluation-of-floating-tablets-of-venlafaxine-hydrochloride" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16234.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">543</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">146</span> Formulation Design and Optimization of Orodispersible Tablets of Diphenhydramine Hydrochloride Having Adequate Mechanical Strength</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jiwan%20P.%20Lavande">Jiwan P. Lavande</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20V.%20Chandewar"> A. V. Chandewar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, orodispersible tablets of diphenhydramine hydrochloride were prepared using croscarmellose sodium, crospovidone and camphor, menthol (as subliming agents) in different ratios and ODTs prepared with superdisintegrants were compared with ODTs prepared with camphor and menthol (subliming agents) for the following evaluation of in vitro disintegration time, dispersion time, wetting time, hardness and water absorption ratio. Results revealed that the tablets of all formulations have acceptable physical parameters. The drug and excipients compatibility study was evaluated using FTIR technique and has not detected any incompatibility. The in vitro release of drug from DC6 formulation was quick when compared to other formulations. Stability study was carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets had not shown any significant difference. Microscopic study of different formulations of sublimed tablets showed formation of pores for the tablets prepared by sublimation method. Thus, conclusion can be made that the stable orodispersible tablets of diphenhydramine hydrochloride can be developed for the rapid release of diphenhydramine hydrochloride. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=orodispersible%20tablet" title="orodispersible tablet">orodispersible tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=subliming%20agent" title=" subliming agent"> subliming agent</a>, <a href="https://publications.waset.org/abstracts/search?q=super%20disintegrants" title=" super disintegrants"> super disintegrants</a>, <a href="https://publications.waset.org/abstracts/search?q=diphenhydramine%20hydrochloride" title=" diphenhydramine hydrochloride"> diphenhydramine hydrochloride</a> </p> <a href="https://publications.waset.org/abstracts/4238/formulation-design-and-optimization-of-orodispersible-tablets-of-diphenhydramine-hydrochloride-having-adequate-mechanical-strength" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/4238.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">235</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">145</span> Optimization of Moisture Content for Highest Tensile Strength of Instant Soluble Milk Tablet and Flowability of Milk Powder</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Siddharth%20Vishwakarma">Siddharth Vishwakarma</a>, <a href="https://publications.waset.org/abstracts/search?q=Danie%20Shajie%20A."> Danie Shajie A.</a>, <a href="https://publications.waset.org/abstracts/search?q=Mishra%20H.%20N."> Mishra H. N.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Milk powder becomes very useful in the low milk supply area but the exact amount to add for one glass of milk and the handling is difficult. So, the idea of instant soluble milk tablet comes into existence for its high solubility and easy handling. The moisture content of milk tablets is increased by the direct addition of water with no additives for binding. The variation of the tensile strength of instant soluble milk tablets and the flowability of milk powder with the moisture content is analyzed and optimized for the highest tensile strength of instant soluble milk tablets and flowability, above a particular value of milk powder using response surface methodology. The flowability value is necessary for ease in quantifying the milk powder, as a feed, in the designed tablet making machine. The instant soluble nature of milk tablets purely depends upon the disintegration characteristic of tablets in water whose study is under progress. Conclusions: The optimization results are very useful in the commercialization of milk tablets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=flowability" title="flowability">flowability</a>, <a href="https://publications.waset.org/abstracts/search?q=milk%20powder" title=" milk powder"> milk powder</a>, <a href="https://publications.waset.org/abstracts/search?q=response%20surface%20methodology" title=" response surface methodology"> response surface methodology</a>, <a href="https://publications.waset.org/abstracts/search?q=tablet%20making%20machine" title=" tablet making machine"> tablet making machine</a>, <a href="https://publications.waset.org/abstracts/search?q=tensile%20strength" title=" tensile strength"> tensile strength</a> </p> <a href="https://publications.waset.org/abstracts/101034/optimization-of-moisture-content-for-highest-tensile-strength-of-instant-soluble-milk-tablet-and-flowability-of-milk-powder" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/101034.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">180</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">144</span> Development and Efficacy Assessment of an Enteric Coated Porous Tablet Loaded with F4 Fimbriae for Oral Vaccination against Enterotoxigenic Escherichia coli Infections</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atul%20Srivastava">Atul Srivastava</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20V.%20Gowda"> D. V. Gowda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Enterotoxigenic Escherichia coli (ETEC) infection is one of the major causes contributing to the development of diarrhoea in adults and children in developing countries. To date, no preventive/treatment strategy showed promising results, which could be due to the lack of potent vaccines, and/or due to the development of resistance of ETEC to antibiotics. Therefore, in the present investigation, a novel porous Sodium Alginate (SA) tablet formulation loaded with F4 fimbriae antigen was developed and tested for efficacy against ETEC infections in piglet models. Pre-compression parameters of the powder mixes and post compression parameters of tablets have been evaluated and results were found to be satisfactory. Loading of F4 fimbrial antigens in to the tablets was achieved by inducing pores in the tablets via the sublimation of camphor followed by incubation with purified F4 fimbriae. The loaded tablets have been coated with Eudragit L100 to protect the F4 fimbriae from (a) highly acidic gastric environment; (b) proteolytic cleavage by pepsin; and (c) to promote subsequent release in the intestine. Evaluation of developed F4 fimbrial tablets in a Pig model demonstrated induction of mucosal immunity, and a signiﬁcant reduction of F4+ E. coli in faeces. Therefore, F4 fimbriae loaded porous tablets could be a novel oral vaccination candidate to induce mucosal and systemic immunity against ETEC infections. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=porous%20tablets" title="porous tablets">porous tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=sublimation" title=" sublimation"> sublimation</a>, <a href="https://publications.waset.org/abstracts/search?q=f4%20fimbriae" title=" f4 fimbriae"> f4 fimbriae</a>, <a href="https://publications.waset.org/abstracts/search?q=eudragit%20l100" title=" eudragit l100"> eudragit l100</a>, <a href="https://publications.waset.org/abstracts/search?q=vaccination" title=" vaccination"> vaccination</a> </p> <a href="https://publications.waset.org/abstracts/27290/development-and-efficacy-assessment-of-an-enteric-coated-porous-tablet-loaded-with-f4-fimbriae-for-oral-vaccination-against-enterotoxigenic-escherichia-coli-infections" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">143</span> Formulation and Evaluation of Dispersible Tablet of Furosemide for Pediatric Use</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=O.%20Benaziz">O. Benaziz</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Dorbane"> A. Dorbane</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Djeraba"> S. Djeraba</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of this work is to formulate a dry dispersible form of furosemide in the context of pediatric dose adjustment. To achieve this, we have produced a set of formulas that will be tested in process and after compression. The formula with the best results will be improved to optimize the final shape of the product. Furosemide is the most widely used pediatric diuretic because of its low toxicity. The manufacturing process was chosen taking into account all the data relating to the active ingredient and the excipients used and complying with the specifications and requirements of dispersible tablets. The process used to prepare these tablets was wet granulation. Different excipients were used: lactose, maize starch, magnesium stearate and two superdisintegrants. The mode of incorporation of super-disintegrant changes with each formula. The use of super-disintegrant in the formula allowed optimization of the disintegration time. Prepared tablets were evaluated for weight, content uniformity, hardness, disintegration time, friability and <em>in vitro</em> dissolution test.  <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=formulation" title="formulation">formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=dispersible%20tablets" title=" dispersible tablets"> dispersible tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=wet%20granulation" title=" wet granulation"> wet granulation</a>, <a href="https://publications.waset.org/abstracts/search?q=superdisintegrants" title=" superdisintegrants"> superdisintegrants</a>, <a href="https://publications.waset.org/abstracts/search?q=disintegration" title=" disintegration"> disintegration</a> </p> <a href="https://publications.waset.org/abstracts/81137/formulation-and-evaluation-of-dispersible-tablet-of-furosemide-for-pediatric-use" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81137.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">345</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">142</span> Formulation and in vitro Evaluation of Sustained Release Matrix Tablets of Levetiracetam for Better Epileptic Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nagasamy%20Venkatesh%20Dhandapani">Nagasamy Venkatesh Dhandapani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of the present study was to develop sustained release oral matrix tablets of anti epileptic drug levetiracetam. The sustained release matrix tablets of levetiracetam were prepared using hydrophilic matrix hydroxypropyl methylcellulose (HPMC) as a release retarding polymer by wet granulation method. Prior to compression, FTIR studies were performed to understand the compatibility between the drug and excipients. The study revealed that there was no chemical interaction between drug and excipients used in the study. The tablets were characterized by physical and chemical parameters and results were found in acceptable limits.<em> In vitro</em> release study was carried out for the tablets using 0.1 N HCl for 2 hours and in phosphate buffer pH 7.4 for remaining time up to 12 hours. The effect of polymer concentration was studied. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. The drug release data fit well to zero order kinetics. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=levetiracetam" title="levetiracetam">levetiracetam</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained-release" title=" sustained-release"> sustained-release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic%20matrix%20tablet" title=" hydrophilic matrix tablet"> hydrophilic matrix tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=HPMC%20grade%20K%20100%20MCR" title=" HPMC grade K 100 MCR"> HPMC grade K 100 MCR</a>, <a href="https://publications.waset.org/abstracts/search?q=wet%20granulation" title=" wet granulation"> wet granulation</a>, <a href="https://publications.waset.org/abstracts/search?q=zero%20order%20release%20kinetics" title=" zero order release kinetics"> zero order release kinetics</a> </p> <a href="https://publications.waset.org/abstracts/58363/formulation-and-in-vitro-evaluation-of-sustained-release-matrix-tablets-of-levetiracetam-for-better-epileptic-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58363.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">141</span> Development of Hierarchically Structured Tablets with 3D Printed Inclusions for Controlled Drug Release</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Veronika%20Les%C3%A1kov%C3%A1">Veronika Lesáková</a>, <a href="https://publications.waset.org/abstracts/search?q=Silvia%20Slez%C3%A1kov%C3%A1"> Silvia Slezáková</a>, <a href="https://publications.waset.org/abstracts/search?q=Franti%C5%A1ek%20%C5%A0t%C4%9Bp%C3%A1nek"> František Štěpánek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Drug dosage forms consisting of multi-unit particle systems (MUPS) for modified drug release provide a promising route for overcoming the limitation of conventional tablets. Despite the conventional use of pellets as units for MUP systems, 3D printed polymers loaded with a drug seem like an interesting candidate due to the control over dosing that 3D printing mechanisms offer. Further, 3D printing offers high flexibility and control over the spatial structuring of a printed object. The final MUPS tablets include PVP and HPC as granulate with other excipients, enabling the compaction process of this mixture with 3D printed inclusions, also termed minitablets. In this study, we have developed the multi-step production process for MUPS tablets, including the 3D printing technology. The MUPS tablets with incorporated 3D printed minitablets are a complex system for drug delivery, providing modified drug release. Such structured tablets promise to reduce drug fluctuations in blood, risk of local toxicity, and increase bioavailability, resulting in an improved therapeutic effect due to the fast transfer into the small intestine, where particles are evenly distributed. Drug loaded 3D printed minitablets were compacted into the excipient mixture, influencing drug release through varying parameters, such as minitablets size, matrix composition, and compaction parameters. Further, the mechanical properties and morphology of the final MUPS tablets were analyzed as many properties, such as plasticity and elasticity, can significantly influence the dissolution profile of the drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=dissolution%20kinetics" title=" dissolution kinetics"> dissolution kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hot-melt%20extrusion" title=" hot-melt extrusion"> hot-melt extrusion</a> </p> <a href="https://publications.waset.org/abstracts/151230/development-of-hierarchically-structured-tablets-with-3d-printed-inclusions-for-controlled-drug-release" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/151230.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">92</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">140</span> Development of Oral Biphasic Drug Delivery System Using a Natural Resourced Polymer, Terminalia catappa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Venkata%20Srikanth%20Meka">Venkata Srikanth Meka</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Arthirah%20Binti%20Ahmad%20Tarmizi%20Tan"> Nur Arthirah Binti Ahmad Tarmizi Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Syahmi%20Bin%20Md%20Nazir"> Muhammad Syahmi Bin Md Nazir</a>, <a href="https://publications.waset.org/abstracts/search?q=Adinarayana%20Gorajana"> Adinarayana Gorajana</a>, <a href="https://publications.waset.org/abstracts/search?q=Senthil%20Rajan%20Dharmalingam"> Senthil Rajan Dharmalingam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biphasic drug delivery systems are designed to release drug at two different rates, either fast/prolonged or prolonged/fast. A fast/prolonged release system provides a burst drug release at initial stage followed by a slow release over a prolonged period of time and in case of prolonged/fast release system, the release pattern is vice versa. Terminalia catappa gum (TCG) is a natural polymer and was successfully proven as a novel pharmaceutical excipient. The main objective of the present research is to investigate the applicability of natural polymer, Terminalia catappa gum in the design of oral biphasic drug delivery system in the form of mini tablets by using a model drug, buspirone HCl. This investigation aims to produce a biphasic release drug delivery system of buspirone by combining immediate release and prolonged release mini tablets into a capsule. For immediate release mini tablets, a dose of 4.5 mg buspirone was prepared by varying the concentration of superdisintegrant; crospovidone. On the other hand, prolonged release mini tablets were produced by using different concentrations of the natural polymer; TCG with a buspirone dose of 3mg. All mini tablets were characterized for weight variation, hardness, friability, disintegration, content uniformity and dissolution studies. The optimized formulations of immediate and prolonged release mini tablets were finally combined in a capsule and was evaluated for release studies. FTIR and DSC studies were conducted to study the drug-polymer interaction. All formulations of immediate release and prolonged release mini tablets were passed all the in-process quality control tests according to US Pharmacopoeia. The disintegration time of immediate release mini tablets of different formulations was varied from 2-6 min, and maximum drug release was achieved in lesser than 60 min. Whereas prolonged release mini tablets made with TCG have shown good drug retarding properties. Formulations were controlled for about 4-10 hrs with varying concentration of TCG. As the concentration of TCG increased, the drug release retarding property also increased. The optimised mini tablets were packed in capsules and were evaluated for the release mechanism. The capsule dosage form has clearly exhibited the biphasic release of buspirone, indicating that TCG is a suitable natural polymer for this study. FTIR and DSC studies proved that there was no interaction between the drug and polymer. Based on the above positive results, it can be concluded that TCG is a suitable polymer for the biphasic drug delivery systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Terminalia%20catappa%20gum" title="Terminalia catappa gum">Terminalia catappa gum</a>, <a href="https://publications.waset.org/abstracts/search?q=biphasic%20release" title=" biphasic release"> biphasic release</a>, <a href="https://publications.waset.org/abstracts/search?q=mini%20tablets" title=" mini tablets"> mini tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=tablet%20in%20capsule" title=" tablet in capsule"> tablet in capsule</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20polymers" title=" natural polymers"> natural polymers</a> </p> <a href="https://publications.waset.org/abstracts/50516/development-of-oral-biphasic-drug-delivery-system-using-a-natural-resourced-polymer-terminalia-catappa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50516.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">393</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">139</span> 3D Printing of Dual Tablets: Modified Multiple Release Profiles for Personalized Medicine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Veronika%20Les%C3%A1kov%C3%A1">Veronika Lesáková</a>, <a href="https://publications.waset.org/abstracts/search?q=Silvia%20Slez%C3%A1kov%C3%A1"> Silvia Slezáková</a>, <a href="https://publications.waset.org/abstracts/search?q=Franti%C5%A1ek%20%C5%A0t%C4%9Bp%C3%A1nek"> František Štěpánek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Additive manufacturing technologies producing drug dosage forms aimed at personalized medicine applications are promising strategies with several advantages over the conventional production methods. One of the emerging technologies is 3D printing which reduces manufacturing steps and thus allows a significant drop in expenses. A decrease in material consumption is also a highly impactful benefit as the tested drugs are frequently expensive substances. In addition, 3D printed dosage forms enable increased patient compliance and prevent misdosing as the dosage forms are carefully designed according to the patient’s needs. The incorporation of multiple drugs into a single dosage form further increases the degree of personalization. Our research focuses on the development of 3D printed tablets incorporating multiple drugs (candesartan, losartan) and thermoplastic polymers (e.g., KlucelTM HPC EF). The filaments, an essential feed material for 3D printing,wereproduced via hot-melt extrusion. Subsequently, the extruded filaments of various formulations were 3D printed into tablets using an FDM 3D printer. Then, we have assessed the influence of the internal structure of 3D printed tablets and formulation on dissolution behaviour by obtaining the dissolution profiles of drugs present in the 3D printed tablets. In conclusion, we have developed tablets containing multiple drugs providing modified release profiles. The 3D printing experiments demonstrate the high tunability of 3D printing as each tablet compartment is constructed with a different formulation. Overall, the results suggest that the 3D printing technology is a promising manufacturing approach to dual tablet preparation for personalized medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hot-melt%20extrusion" title=" hot-melt extrusion"> hot-melt extrusion</a>, <a href="https://publications.waset.org/abstracts/search?q=dissolution%20kinetics" title=" dissolution kinetics"> dissolution kinetics</a> </p> <a href="https://publications.waset.org/abstracts/144631/3d-printing-of-dual-tablets-modified-multiple-release-profiles-for-personalized-medicine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144631.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">168</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">138</span> Formulation of Extended-Release Gliclazide Tablet Using a Mathematical Model for Estimation of Hypromellose</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of gliclazide in the form of extended-release tablet in 30 and 60 mg dosage forms was performed using hypromellose (HPMC K4M) as a retarding agent. Drug-release profiles were investigated in comparison with references Diamicron MR 30 and 60 mg tablets. The effect of size of powder particles, the amount of hypromellose in formulation, hardness of tablets, and also the effect of halving the tablets were investigated on drug release profile. A mathematical model which describes hypromellose behavior in initial times of drug release was proposed for the estimation of hypromellose content in modified-release gliclazide 60 mg tablet. This model is based on erosion of hypromellose in dissolution media. The model is applicable to describe release profiles of insoluble drugs. Therefore, by using dissolved amount of drug in initial times of dissolution and the model, the amount of hypromellose in formulation can be predictable. The model was used to predict the HPMC K4M content in modified-release gliclazide 30 mg and extended-release quetiapine 200 mg tablets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gliclazide" title="Gliclazide">Gliclazide</a>, <a href="https://publications.waset.org/abstracts/search?q=hypromellose" title=" hypromellose"> hypromellose</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=modified-release%20tablet" title=" modified-release tablet"> modified-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical%20model" title=" mathematical model"> mathematical model</a> </p> <a href="https://publications.waset.org/abstracts/75442/formulation-of-extended-release-gliclazide-tablet-using-a-mathematical-model-for-estimation-of-hypromellose" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75442.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">222</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">137</span> Grape Seed Extract and Zinc Containing Multivitamin-Mineral Nutritional Food Supplement Protects Heart against Myocardial Ischemic-Reperfusion Injury in Wistar Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20M.%20Satyam">S. M. Satyam</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20L.%20Bairy"> K. L. Bairy</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Pirasanthan"> R. Pirasanthan</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20L.%20Vaishnav"> R. L. Vaishnav</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Zincovit tablets have been used as nutritional food supplement over a prolonged period of time. The aim of the present study was to investigate the cardio-protective effect of combined formulation of grape seed extract and Zincovit tablets (40, 80 and 160 mg/kg) using a Langendorff model of ischemia-reperfusion in Wistar rats. Following 21 days of pre-treatment, combined formulation of grape seed extract and Zincovit tablets significantly attenuated ischemia-reperfusion induced cardiac injury in terms of increased coronary flow rate (p < 0.01), decreased creatine kinase activity in coronary effluent (p < 0.05), decreased MDA (p < 0.001), 4-HNE (p < 0.001) and increased protein thiol content (p < 0.01) in comparison with the untreated (control) group. This study opens an avenue to clinical studies to demonstrate the validity of this paradigm as a nutritional food supplement, which could improve the clinical outcome of patients subjected to percutaneous angioplasty. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=grape%20seed%20extract" title="grape seed extract">grape seed extract</a>, <a href="https://publications.waset.org/abstracts/search?q=myocardial%20ischemia-reperfusion%20injury" title=" myocardial ischemia-reperfusion injury"> myocardial ischemia-reperfusion injury</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=Zincovit%20tablets" title=" Zincovit tablets "> Zincovit tablets </a> </p> <a href="https://publications.waset.org/abstracts/13015/grape-seed-extract-and-zinc-containing-multivitamin-mineral-nutritional-food-supplement-protects-heart-against-myocardial-ischemic-reperfusion-injury-in-wistar-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13015.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">376</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">136</span> Formulation of Highly Dosed Drugs Using Different Granulation Techniques: A Comparative Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ezeddin%20Kolaib">Ezeddin Kolaib</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Paracetamol tablets and cimetidine tablets were prepared by single-step granulation/tabletting and by compression after high shear granulation. The addition of PVP (polyvinylpyrrolidone) was essential for single-step granulation/tabletting of formulation containing high concentrations of paracetamol or cimetidine. Paracetamol tablets without and with PVP obtained by single-step granulation/tabletting exhibited a significantly higher tensile strength, a significantly lower disintegration time, a lower friability and a faster dissolution compared to those prepared by compression after high shear granulation. Cimetidine tablets with PVP obtained by single-step granulation/tabletting exhibited a significantly lower tensile strength, a significantly lower disintegration time and a faster dissolution compared to those prepared by compression after high shear granulation. Single-step granulation/tabletting allowed to produce tablets containing up to 80% paracetamol or cimetidine with a dissolution profile complying with the USP requirements. For pure paracetamol or pure cimetidine the addition of crospovidone as a disintegrant was required to obtain a dissolution profile that complied with the pharmacopoeial requirements. Long term and accelerated stability studies of paracetamol tablets produced by single-step granulation/tabletting over a period of one year showed no significant influence on the tablet tensile strength, friability and dissolution. Although a significant increase of the disintegration time was observed, it remained below 10 min. These results indicated that single-step granulation/tabletting could be an efficient technique for the production of highly dosed drugs such as paracetamol and cimetidine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=single-step%20granulation%2Ftabletting" title="single-step granulation/tabletting">single-step granulation/tabletting</a>, <a href="https://publications.waset.org/abstracts/search?q=twin%20screw%20extrusion" title=" twin screw extrusion"> twin screw extrusion</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20shear%20granulation" title=" high shear granulation"> high shear granulation</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20dosage%20drugs" title=" high dosage drugs"> high dosage drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=paracetamol" title=" paracetamol"> paracetamol</a>, <a href="https://publications.waset.org/abstracts/search?q=cimetidine" title=" cimetidine"> cimetidine</a> </p> <a href="https://publications.waset.org/abstracts/18765/formulation-of-highly-dosed-drugs-using-different-granulation-techniques-a-comparative-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18765.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">135</span> Influence of the Compression Force and Powder Particle Size on Some Physical Properties of Date (Phoenix dactylifera) Tablets</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Djemaa%20Megdoud">Djemaa Megdoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Messaoud%20Boudaa"> Messaoud Boudaa</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatima%20Ouamrane"> Fatima Ouamrane</a>, <a href="https://publications.waset.org/abstracts/search?q=Salem%20Benamara"> Salem Benamara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, the compression of date (Phoenix dactylifera L.) fruit powders (DP) to obtain date tablets (DT) has been suggested as a promising form of valorization of non commercial valuable date fruit (DF) varieties. To further improve and characterize DT, the present study aims to investigate the influence of the DP particle size and compression force on some physical properties of DT. The results show that independently of particle size, the hardness (y) of tablets increases with the increase of the compression force (x) following a logarithmic law (y = a ln (bx) where a and b are the constants of model). Further, a full factorial design (FFD) at two levels, applied to investigate the erosion %, reveals that the effects of time and particle size are the same in absolute value and they are beyond the effect of the compression. Regarding the disintegration time, the obtained results also by means of a FFD show that the effect of the compression force exceeds 4 times that of the DP particle size. As final stage, the color parameters in the CIELab system of DT immediately after their obtaining are differently influenced by the size of the initial powder. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=powder" title="powder">powder</a>, <a href="https://publications.waset.org/abstracts/search?q=tablets" title=" tablets"> tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=date%20%28Phoenix%20dactylifera%20L.%29" title=" date (Phoenix dactylifera L.)"> date (Phoenix dactylifera L.)</a>, <a href="https://publications.waset.org/abstracts/search?q=hardness" title=" hardness"> hardness</a>, <a href="https://publications.waset.org/abstracts/search?q=erosion" title=" erosion"> erosion</a>, <a href="https://publications.waset.org/abstracts/search?q=disintegration%20time" title=" disintegration time"> disintegration time</a>, <a href="https://publications.waset.org/abstracts/search?q=color" title=" color"> color</a> </p> <a href="https://publications.waset.org/abstracts/16986/influence-of-the-compression-force-and-powder-particle-size-on-some-physical-properties-of-date-phoenix-dactylifera-tablets" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16986.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">430</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">134</span> Investigation of an Approach in Drug Delivery: Orally Fast Disintegrating Tablets </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tansel%20Comoglu">Tansel Comoglu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Orally fast disintegrating tablets (FDTs or ODTs) have become popular during the last decade, and manufacturing of ODTs is getting a rapidly growing area in the pharmaceutical industry. The concept of ODTs has emerged from the desire to provide patients with more conventional means of taking their medication. Drugs, that have satisfactory absorption from the oral mucosa or aimed for immediate therapeutic activity can be formulated in ODTs. After placing the ODT into the mouth, these tablets dissolve or disintegrate in the mouth usullay less than a minute, in the absence of additional water. Even though the ODT technology has taken an important path, as proved by a large group of commercial products on the drug market, there are so many problems to be solved in ODT formulations such as; formulation of hydrophobic drugs is stil a challenge, especially when the amount of drug is high. As these tablets dissolve or disintegrate in the mouth without the need of additional water, taste masking of active ingredients becomes essential in these systems because the drug is entirely released in the mouth. In ODT technology, coping with the taste of drugs is still a challenge. Resins or sweeteners or other techniques are also used in the formulation to aid taste-masking of the API. Another important factor to consider is whether they can be manufactured using conventional equipment and processes, as this will have a positive influence on manufacturing costs. Some products, however, may require a more costly, special unitdose packaging if the dosage form is fragile. In this overview, benefits, various formulation technologies, clinical studies and some future research trends of ODTs will be discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=orally%20fast%20disintegrating%20tablets" title="orally fast disintegrating tablets">orally fast disintegrating tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=benefits" title=" benefits"> benefits</a>, <a href="https://publications.waset.org/abstracts/search?q=formulation%20technologies" title=" formulation technologies"> formulation technologies</a>, <a href="https://publications.waset.org/abstracts/search?q=future%20research%20trends" title=" future research trends"> future research trends</a> </p> <a href="https://publications.waset.org/abstracts/62886/investigation-of-an-approach-in-drug-delivery-orally-fast-disintegrating-tablets" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62886.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">133</span> Development and Evaluation of Gastro Retentive Floating Tablets of Ayurvedic Vati Formulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Imran%20Khan%20Pathan">Imran Khan Pathan</a>, <a href="https://publications.waset.org/abstracts/search?q=Anil%20Bhandari"> Anil Bhandari</a>, <a href="https://publications.waset.org/abstracts/search?q=Peeyush%20K.%20Sharma"> Peeyush K. Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Rakesh%20K.%20Patel"> Rakesh K. Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Suresh%20Purohit"> Suresh Purohit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50 LV act as Matrixing agent, Carbopol as floating enhancer, microcrystalline cellulose as binder, sodium bi carbonate as effervescent agent with other excipients. The simplex lattice design was used for selection of variables for tablets formulation. Formulation was optimized on the basis of floating time and in vitro drug release. The results showed that the floating lag time for optimized formulation was found to be 61 second with about 97.32 % of total drug release within 3 hours. The in vitro release profiles of drug from the formulation could be best expressed zero order with highest linearity r2 = 0.9943. It was concluded that the gastroretentive drug delivery system can be developed for Marichyadi Vati containing piperine to increase the residence time of the drug in the stomach and thereby increasing bioavailability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=piperine" title="piperine">piperine</a>, <a href="https://publications.waset.org/abstracts/search?q=Marichyadi%20Vati" title=" Marichyadi Vati"> Marichyadi Vati</a>, <a href="https://publications.waset.org/abstracts/search?q=gastroretentive%20drug%20delivery" title=" gastroretentive drug delivery"> gastroretentive drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=floating%20tablet" title=" floating tablet"> floating tablet</a> </p> <a href="https://publications.waset.org/abstracts/1702/development-and-evaluation-of-gastro-retentive-floating-tablets-of-ayurvedic-vati-formulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1702.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">457</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">132</span> Dimensionless Binding Values in the Evaluation of Paracetamol Tablet Formulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abayomi%20T.%20Ogunjimi">Abayomi T. Ogunjimi</a>, <a href="https://publications.waset.org/abstracts/search?q=Gbenga%20Alebiowu"> Gbenga Alebiowu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mechanical properties of paracetamol tablets containing Neem (Azadirachta indica) gum were compared with standard Acacia gum BP as binder. Two dimensionless binding quantities BEN and BEC were used in assessing the influence of binder type on two mechanical properties, Tensile Strength (TS) and Brittle Fracture Index (BFI). The two quantities were also used to assess the influence of relative density and binder concentration on TS and BFI as well as compare Binding Efficiencies (BE). The result shows that TS is dependent on relative density, binder type and binder concentration while BFI is dependent on the binder type and binder concentration; and that although, the inclusion of NMG in a paracetamol tablet formulation may not enhance the TS of the tablets produced, however it will decrease the tendency of the tablets to cap or laminate. This work concludes that BEN may be useful in quantitative assessment while BEC may be appropriate for qualitative assessment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=binding%20efficiency" title="binding efficiency">binding efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=brittle%20fracture%20index" title=" brittle fracture index"> brittle fracture index</a>, <a href="https://publications.waset.org/abstracts/search?q=dimensionless%20binding" title=" dimensionless binding"> dimensionless binding</a>, <a href="https://publications.waset.org/abstracts/search?q=tensile%20strength" title=" tensile strength"> tensile strength</a> </p> <a href="https://publications.waset.org/abstracts/2503/dimensionless-binding-values-in-the-evaluation-of-paracetamol-tablet-formulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2503.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">253</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">131</span> Forced Degradation Study of Rifaximin Formulated Tablets to Determine Stability Indicating Nature of High-Performance Liquid Chromatography Analytical Method </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abid%20Fida%20Masih">Abid Fida Masih</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Forced degradation study of Rifaximin was conducted to determine the stability indicating potential of HPLC testing method for detection of Rifaximin in formulated tablets to be employed for quality control and stability testing. The questioned method applied with mobile phase methanol: water (70:30), 5µm, 250 x 4.6mm, C18 column, wavelength 293nm and flow rate of 1.0 ml/min. Forced degradation study was performed under oxidative, acidic, basic, thermal and photolytic conditions. The applied method successfully determined the degradation products after acidic and basic degradation without interfering with Rifaximin detection. Therefore, the method was said to be stability indicating and can be applied for quality control and stability testing of Rifaxmin tablets during its shelf life. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=forced%20degradation" title="forced degradation">forced degradation</a>, <a href="https://publications.waset.org/abstracts/search?q=high-performance%20liquid%20chromatography" title=" high-performance liquid chromatography"> high-performance liquid chromatography</a>, <a href="https://publications.waset.org/abstracts/search?q=method%20validation" title=" method validation"> method validation</a>, <a href="https://publications.waset.org/abstracts/search?q=rifaximin" title=" rifaximin"> rifaximin</a>, <a href="https://publications.waset.org/abstracts/search?q=stability%20indicating%20method" title=" stability indicating method"> stability indicating method</a> </p> <a href="https://publications.waset.org/abstracts/76445/forced-degradation-study-of-rifaximin-formulated-tablets-to-determine-stability-indicating-nature-of-high-performance-liquid-chromatography-analytical-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76445.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">313</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">130</span> Solid Dosages Form Tablet: A Summary on the Article by Shashank Tiwari</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shashank%20Tiwari">Shashank Tiwari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The most common method of drug delivery is the oral solid dosage form, of which tablets and capsules are predominant. The tablet is more widely accepted and used compared to capsules for a number of reasons, such as cost/price, tamper resistance, ease of handling and packaging, ease of identification, and manufacturing efficiency. Over the past several years, the issue of tamper resistance has resulted in the conversion of most over-the-counter (OTC) drugs from capsules to predominantly all tablets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=capsule" title="capsule">capsule</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=dosages" title=" dosages"> dosages</a>, <a href="https://publications.waset.org/abstracts/search?q=solid" title=" solid"> solid</a>, <a href="https://publications.waset.org/abstracts/search?q=tablet" title=" tablet"> tablet</a> </p> <a href="https://publications.waset.org/abstracts/35793/solid-dosages-form-tablet-a-summary-on-the-article-by-shashank-tiwari" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35793.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">438</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">129</span> Patient’s Knowledge and Use of Sublingual Glyceryl Trinitrate Therapy in Taiping Hospital, Malaysia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wan%20Azuati%20Wan%20Omar">Wan Azuati Wan Omar</a>, <a href="https://publications.waset.org/abstracts/search?q=Selva%20Rani%20John%20Jasudass"> Selva Rani John Jasudass</a>, <a href="https://publications.waset.org/abstracts/search?q=Siti%20Rohaiza%20Md.%20Saad"> Siti Rohaiza Md. Saad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction & objective: The objectives of this study were to assess patient’s knowledge of appropriate sublingual glyceryl trinitrate (GTN) use as well as to investigate how patients commonly store and carry their sublingual GTN tablets. Methodology: This was a cross-sectional survey, using a validated researcher-administered questionnaire. The study involved cardiac patients receiving sublingual GTN attending the outpatient and inpatient departments of Taiping Hospital, a non-academic public care hospital. The minimum calculated sample size was 92, but 100 patients were conveniently sampled. Respondents were interviewed on 3 areas, including demographic data, knowledge and use of sublingual GTN. Eight items were used to calculate each subject’s knowledge score and six items were used to calculate use score. Results: Of the 96 patients who consented to participate, majority (96.9%) were well aware of the indication of sublingual GTN. With regards to the mechanism of action of sublingual GTN, 73 (76%) patients did not know how the medication works. Majority of the patients (66.7%) knew about the proper storage of the tablet. In relation to the maximum number of sublingual GTN tablets that can be taken during each angina episode, 36.5% did not know that up to 3 tablets of sublingual GTN can be taken during each episode of angina. Fifty four (56.2%) patients were not aware that they need to replace sublingual GTN every 8 weeks after receiving the tablets. Majority (69.8%) of the patients demonstrated lack of knowledge with regards to the use of sublingual GTN as prevention of chest pain. Conclusion: Overall, patients’ knowledge regarding the self administration of sublingual GTN is still inadequate. The findings support the need for more frequent reinforcement of patient education, especially in the areas of preventive use, storage and drug stability. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glyceryl%20trinitrate" title="glyceryl trinitrate">glyceryl trinitrate</a>, <a href="https://publications.waset.org/abstracts/search?q=knowledge" title=" knowledge"> knowledge</a>, <a href="https://publications.waset.org/abstracts/search?q=adherence" title=" adherence"> adherence</a>, <a href="https://publications.waset.org/abstracts/search?q=patient%20education" title=" patient education"> patient education</a> </p> <a href="https://publications.waset.org/abstracts/9230/patients-knowledge-and-use-of-sublingual-glyceryl-trinitrate-therapy-in-taiping-hospital-malaysia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9230.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">397</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">128</span> Formulation and In vivo Evaluation of Venlafaxine Hydrochloride Long Acting Tablet</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdulwahhab%20Khedr">Abdulwahhab Khedr</a>, <a href="https://publications.waset.org/abstracts/search?q=Tamer%20Shehata"> Tamer Shehata</a>, <a href="https://publications.waset.org/abstracts/search?q=Hanaa%20El-Ghamry"> Hanaa El-Ghamry</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Venlafaxine HCl is a novel antidepressant drug used in the treatment of major depressive disorder, generalized anxiety disorder, social anxiety disorder and panic disorder. Conventional therapeutic regimens with venlafaxine HCl immediate-release dosage forms require frequent dosing due to short elimination half-life of the drug and reduced bioavailability. Hence, this study was carried out to develop sustained-release dosage forms of venlafaxine HCl to reduce its dosing frequency, to improve patient compliance and to reduce side effects of the drug. The polymers used were hydroxypropylmethyl cellulose, xanthan gum, sodium alginate, sodium carboxymethyl cellulose, Carbopol 940 and ethyl cellulose. The physical properties of the prepared tablets including tablet thickness, diameter, weight uniformity, content uniformity, hardness and friability were evaluated. Also, the in-vitro release of venlafaxine HCl from different matrix tablets was studied. Based on physical characters and in-vitro release profiles, certain formulae showing promising sustained-release profiles were subjected to film coating with 15% w/v EC in dichloromethane/ethanol mixture (1:1 ratio) using 1% w/v HPMC as pore former and 30% w/w dibutyl phthalate as plasticizer. The optimized formulations were investigated for drug-excipient compatibility using FTIR and DSC studies. Physical evaluation of the prepared tablets fulfilled the pharmacopoeial requirements for tablet friability test, where the weight loss of the prepared formulae did not exceed 1% of the weight of the tested tablets. Moderate release was obtained from tablets containing HPMC. FTIR and DSC studies for such formulae revealed the absence of any type of chemical interaction between venlafaxine HCl and the used polymers or excipients. Forced swimming test in rats was used to evaluate the antidepressant activity of the selected matrix tablets of venlafaxine HCl. Results showed that formulations significantly decreased the duration of animals’ immobility during the 24 hr-period of the test compared to non-treated group. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antidepressant" title="antidepressant">antidepressant</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained-release" title=" sustained-release"> sustained-release</a>, <a href="https://publications.waset.org/abstracts/search?q=matrix%20tablet" title=" matrix tablet"> matrix tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=venlafaxine%20hydrochloride" title=" venlafaxine hydrochloride"> venlafaxine hydrochloride</a> </p> <a href="https://publications.waset.org/abstracts/54132/formulation-and-in-vivo-evaluation-of-venlafaxine-hydrochloride-long-acting-tablet" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54132.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">240</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">127</span> Design and Development of Buccal Delivery System for Atenolol Tablets by Using Different Bioadhesive Polymers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Venkatalakshmi%20Ranganathan">Venkatalakshmi Ranganathan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ong%20Hsin%20Ju"> Ong Hsin Ju</a>, <a href="https://publications.waset.org/abstracts/search?q=Tan%20Yinn%20Ming"> Tan Yinn Ming</a>, <a href="https://publications.waset.org/abstracts/search?q=Lim%20Kien%20Sin"> Lim Kien Sin</a>, <a href="https://publications.waset.org/abstracts/search?q=Wong%20Man%20Ting"> Wong Man Ting</a>, <a href="https://publications.waset.org/abstracts/search?q=Venkata%20Srikanth%20Meka"> Venkata Srikanth Meka </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The mucoadhesive buccal tablet is an oral drug delivery system which attached to the buccal surface for direct drug absorption into the systemic circulation and the unidirectional drug release is ensured by formulating a hydrophobic backing layer. The objective of present study was to formulate mucoadhesive atenolol bilayer buccal tablets by using sodium alginate, hydroxyethyl cellulose, and xanthan gum as mucoadhesive polymer and the technique applied was direct compression method. Ethyl cellulose was used as backing layer of the tablet. FTIR and DSC analysis were carried out to identify the drug polymer interactions. The prepared tablets were evaluated for physicochemical parameters, ex vivo mucoadhesion time and in-vitro drug release. The formulated tablets showed the average surface pH 6-7 which is favourable for oral mucosa. The formulation containing sodium alginate showed more than 90 % of drug release at the end of the 7 hours in vitro dissolution studies. The formulation containing xanthan gum showed more than 8 hours of mucoadhesion time and all formulation exhibited non fickian release kinetics. The present study indicates enormous potential of erodible mucoadhesive buccal tablet containing atenolol for systemic delivery with an added advantage of circumventing the hepatic first pass metabolism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atenolol" title="atenolol">atenolol</a>, <a href="https://publications.waset.org/abstracts/search?q=mucoadhesion" title=" mucoadhesion"> mucoadhesion</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20drug%20release" title=" in vitro drug release"> in vitro drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=direct%20compression" title=" direct compression"> direct compression</a>, <a href="https://publications.waset.org/abstracts/search?q=ethyl%20cellulose" title=" ethyl cellulose"> ethyl cellulose</a> </p> <a href="https://publications.waset.org/abstracts/21532/design-and-development-of-buccal-delivery-system-for-atenolol-tablets-by-using-different-bioadhesive-polymers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21532.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">619</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">126</span> Determination of the Stability of Haloperidol Tablets and Phenytoin Capsules Stored in the Inpatient Dispensary System (Swisslog) by the Respective HPLC and Raman Spectroscopy Assay</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Carol%20Yue-En%20Ong">Carol Yue-En Ong</a>, <a href="https://publications.waset.org/abstracts/search?q=Angelina%20Hui-Min%20Tan"> Angelina Hui-Min Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=Quan%20Liu"> Quan Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Paul%20Chi-Lui%20Ho"> Paul Chi-Lui Ho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A public general hospital in Singapore has recently implemented an automated unit-dose machine in their inpatient dispensary, Swisslog, with the objective of reducing human error and improving patient safety. However, a concern in stability arises as tablets are removed from their original packaging (bottled loose tablets/capsules) and are repackaged into individual, clear plastic wrappers as unit doses in the system. Drugs that are light-sensitive and hygroscopic would be more susceptible to degradation as the wrapper does not offer full protection. Hence, this study was carried out to study the stability of haloperidol tablets and phenytoin capsules that are light-sensitive and hygroscopic respectively. Validated HPLC-UV assays were first established for quantification of these two compounds. The medications involved were put in the Swisslog and sampled every week for one month. The collected data was analysed and showed no degradation over time. This study also explored an alternative approach for drug stability determination-Raman spectroscopy. The advantage of Raman spectroscopy is its high time efficiency and non-destructive nature. The results suggest that drug degradation can indeed be detected using Raman microscopy, but further research is needed to establish this approach for quantification or qualification of compounds. NanoRam®, a portable Raman spectrocope was also used alongside Raman microscopy but was unsuccessful in detecting degradation in this study. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20stability" title="drug stability">drug stability</a>, <a href="https://publications.waset.org/abstracts/search?q=haloperidol" title=" haloperidol"> haloperidol</a>, <a href="https://publications.waset.org/abstracts/search?q=HPLC" title=" HPLC"> HPLC</a>, <a href="https://publications.waset.org/abstracts/search?q=phenytoin" title=" phenytoin"> phenytoin</a>, <a href="https://publications.waset.org/abstracts/search?q=raman%20spectroscopy" title=" raman spectroscopy"> raman spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=Swisslog" title=" Swisslog"> Swisslog</a> </p> <a href="https://publications.waset.org/abstracts/41916/determination-of-the-stability-of-haloperidol-tablets-and-phenytoin-capsules-stored-in-the-inpatient-dispensary-system-swisslog-by-the-respective-hplc-and-raman-spectroscopy-assay" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41916.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">347</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">125</span> Identifying and Optimizing the Critical Excipients in Moisture Activated Dry Granulation Process for Two Anti TB Drugs of Different Aqueous Solubilities</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Srujana">K. Srujana</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinay%20U.%20Rao"> Vinay U. Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Sudhakar"> M. Sudhakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Isoniazide (INH) a freely water soluble and pyrazinamide (Z) a practically water insoluble first line anti tubercular (TB) drugs were identified as candidates for optimizing the Moisture Activated Dry Granulation (MADG) process. The work focuses on identifying the effect of binder type and concentration as well as the effect of magnesium stearate level on critical quality attributes of Disintegration time (DT) and in vitro dissolution test when the tablets are processed by the MADG process. Also, the level of the drug concentration, binder concentration and fluid addition during the agglomeration stage of the MADG process was evaluated and optimized. For INH, it was identified that for tablets with HPMC as binder at both 2% w/w and 5% w/w level and Magnesium stearate upto 1%w/w as lubrication the DT is within 1 minute and the dissolution rate is the fastest (> 80% in 15 minutes) as compared to when PVP or pregelatinized starch is used as binder. Regarding the process, fast disintegrating and rapidly dissolving tablets are obtained when the level of drug, binder and fluid uptake in agglomeration stage is 25% w/w 0% w/w binder and 0.033%. w/w. At the other 2 levels of these three ingredients, the DT is significantly impacted and dissolution is also slower. For pyrazinamide,it was identified that for the tablets with 2% w/w level of each of PVP as binder and Cross Caramellose Sodium disintegrant the DT is within 2 minutes and the dissolution rate is the fastest(>80 in 15 minutes)as compared to when HPMC or pregelatinized starch is used as binder. This may be attributed to the fact that PVP may be acting as a solubilizer for the practically insoluble Pyrazinamide. Regarding the process,fast dispersing and rapidly disintegrating tablets are obtained when the level of drug, binder and fluid uptake in agglomeration stage is 10% w/w,25% w/w binder and 1% w/w.At the other 2 levels of these three ingredients, the DT is significantly impacted and dissolution is comparatively slower and less complete. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=agglomeration%20stage" title="agglomeration stage">agglomeration stage</a>, <a href="https://publications.waset.org/abstracts/search?q=isoniazide" title=" isoniazide"> isoniazide</a>, <a href="https://publications.waset.org/abstracts/search?q=MADG" title=" MADG"> MADG</a>, <a href="https://publications.waset.org/abstracts/search?q=moisture%20distribution%20stage" title=" moisture distribution stage"> moisture distribution stage</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrazinamide" title=" pyrazinamide "> pyrazinamide </a> </p> <a href="https://publications.waset.org/abstracts/8977/identifying-and-optimizing-the-critical-excipients-in-moisture-activated-dry-granulation-process-for-two-anti-tb-drugs-of-different-aqueous-solubilities" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8977.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">239</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">124</span> An Effort at Improving Reliability of Laboratory Data in Titrimetric Analysis for Zinc Sulphate Tablets Using Validated Spreadsheet Calculators</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20A.%20Okezue">M. A. Okezue</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20L.%20Clase"> K. L. Clase</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20R.%20Byrn"> S. R. Byrn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The requirement for maintaining data integrity in laboratory operations is critical for regulatory compliance. Automation of procedures reduces incidence of human errors. Quality control laboratories located in low-income economies may face some barriers in attempts to automate their processes. Since data from quality control tests on pharmaceutical products are used in making regulatory decisions, it is important that laboratory reports are accurate and reliable. Zinc Sulphate (ZnSO<sub>4</sub>) tablets is used in treatment of diarrhea in pediatric population, and as an adjunct therapy for COVID-19 regimen. Unfortunately, zinc content in these formulations is determined titrimetrically; a manual analytical procedure. The assay for ZnSO4 tablets involves time-consuming steps that contain mathematical formulae prone to calculation errors. To achieve consistency, save costs, and improve data integrity, validated spreadsheets were developed to simplify the two critical steps in the analysis of ZnSO4 tablets: standardization of 0.1M Sodium Edetate (EDTA) solution, and the complexometric titration assay procedure. The assay method in the United States Pharmacopoeia was used to create a process flow for ZnSO<sub>4</sub> tablets. For each step in the process, different formulae were input into two spreadsheets to automate calculations. Further checks were created within the automated system to ensure validity of replicate analysis in titrimetric procedures. Validations were conducted using five data sets of manually computed assay results. The acceptance criteria set for the protocol were met. Significant p-values (p < 0.05, α = 0.05, at 95% Confidence Interval) were obtained from students’ t-test evaluation of the mean values for manual-calculated and spreadsheet results at all levels of the analysis flow. Right-first-time analysis and principles of data integrity were enhanced by use of the validated spreadsheet calculators in titrimetric evaluations of ZnSO<sub>4</sub> tablets. Human errors were minimized in calculations when procedures were automated in quality control laboratories. The assay procedure for the formulation was achieved in a time-efficient manner with greater level of accuracy. This project is expected to promote cost savings for laboratory business models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=data%20integrity" title="data integrity">data integrity</a>, <a href="https://publications.waset.org/abstracts/search?q=spreadsheets" title=" spreadsheets"> spreadsheets</a>, <a href="https://publications.waset.org/abstracts/search?q=titrimetry" title=" titrimetry"> titrimetry</a>, <a href="https://publications.waset.org/abstracts/search?q=validation" title=" validation"> validation</a>, <a href="https://publications.waset.org/abstracts/search?q=zinc%20sulphate%20tablets" title=" zinc sulphate tablets"> zinc sulphate tablets</a> </p> <a href="https://publications.waset.org/abstracts/135407/an-effort-at-improving-reliability-of-laboratory-data-in-titrimetric-analysis-for-zinc-sulphate-tablets-using-validated-spreadsheet-calculators" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135407.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">123</span> Prediction of Incompatibility Between Excipients and API in Gliclazide Tablets Using Infrared Spectroscopy and Principle Component Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recognition of the interaction between active pharmaceutical ingredients (API) and excipients is a pivotal factor in the development of all pharmaceutical dosage forms. By predicting the interaction between API and excipients, we will be able to prevent the advent of impurities or at least lessen their amount. In this study, we used principle component analysis (PCA) to predict the interaction between Gliclazide as a secondary amine with Lactose in pharmaceutical solid dosage forms. The infrared spectra of binary mixtures of Gliclazide with Lactose at different mole ratios were recorded, and the obtained matrix was analyzed with PCA. By plotting score columns of the analyzed matrix, the incompatibility between Gliclazide and Lactose was observed. This incompatibility was seen experimentally. We observed the appearance of the impurity originated from the Maillard reaction between Gliclazide and Lactose at the chromatogram of the manufactured tablets in room temperature and under accelerated stability conditions. This impurity increases at the stability months. By changing Lactose to Mannitol and using Calcium Dibasic Phosphate in the tablet formulation, the amount of the impurity decreased and was in the acceptance range defined by British pharmacopeia for Gliclazide Tablets. This method is a fast and simple way to predict the existence of incompatibility between excipients and active pharmaceutical ingredients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PCA" title="PCA">PCA</a>, <a href="https://publications.waset.org/abstracts/search?q=gliclazide" title=" gliclazide"> gliclazide</a>, <a href="https://publications.waset.org/abstracts/search?q=impurity" title=" impurity"> impurity</a>, <a href="https://publications.waset.org/abstracts/search?q=infrared%20spectroscopy" title=" infrared spectroscopy"> infrared spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=interaction" title=" interaction"> interaction</a> </p> <a href="https://publications.waset.org/abstracts/154962/prediction-of-incompatibility-between-excipients-and-api-in-gliclazide-tablets-using-infrared-spectroscopy-and-principle-component-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154962.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">208</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">122</span> Formulation of Extended-Release Ranolazine Tablet and Investigation Its Stability in the Accelerated Stability Condition at 40⁰C and 75% Humidity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of Ranolazine in the form of extended-release tablet in 500 mg dosage form was performed using Eudragit L100-55 as a retarding agent. Drug-release profiles were investigated in comparison with the reference Ranexa extended-release 500 mg tablet. F₂ and f₁ were calculated as 64.16 and 8.53, respectively. According to Peppas equation, the release of drug is controlled by diffusion (n=0.5). The tablets were put into accelerated stability conditions (40 °C, 75% humidity) for 3 and 6 months. The dissolution release profiles and other physical and chemical characteristics of the tablets confirmed the robustness and stability of formulation in this condition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title="drug release">drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=extended-release%20tablet" title=" extended-release tablet"> extended-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=ranolazine" title=" ranolazine"> ranolazine</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a> </p> <a href="https://publications.waset.org/abstracts/127040/formulation-of-extended-release-ranolazine-tablet-and-investigation-its-stability-in-the-accelerated-stability-condition-at-40c-and-75-humidity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127040.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">121</span> Synthesis Characterisation and Evaluation of Co-Processed Wax Matrix Excipient for Controlled Release Tablets Formulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Kalyan%20Raj">M. Kalyan Raj</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinay%20Umesh%20Rao"> Vinay Umesh Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Sudhakar"> M. Sudhakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The work focuses on the development of a directly compressible controlled release co-processed excipient using melt granulation technique. Erodible wax matrix systems are fabricated in which three different types of waxes are co processed separately with Maize starch in different ratios by melt granulation. The resultant free flowing powder is characterized by FTIR, NMR, Mass spectrophotometer and gel permeation chromatography. Also, controlled release tablets of Aripiprazole were formulated and dissolution profile was compared with that of the target product profile given in Zysis patent (Patent no. 20100004262) for Aripiprazole once a week formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=co-processing" title="co-processing">co-processing</a>, <a href="https://publications.waset.org/abstracts/search?q=hot%20melt%20extrusion" title=" hot melt extrusion"> hot melt extrusion</a>, <a href="https://publications.waset.org/abstracts/search?q=direct%20compression" title=" direct compression"> direct compression</a>, <a href="https://publications.waset.org/abstracts/search?q=maize%20starch" title=" maize starch"> maize starch</a>, <a href="https://publications.waset.org/abstracts/search?q=stearic%20acid" title=" stearic acid"> stearic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=aripiprazole" title=" aripiprazole"> aripiprazole</a> </p> <a href="https://publications.waset.org/abstracts/8897/synthesis-characterisation-and-evaluation-of-co-processed-wax-matrix-excipient-for-controlled-release-tablets-formulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8897.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">408</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">120</span> Determination of Verapamil Hydrochloride in Tablets and Injection Solutions With the Verapamil-Selective Electrode and Possibilities of Application in Pharmaceutical Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Faisal%20A.%20Salih">Faisal A. Salih</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Verapamil hydrochloride (Ver) is a drug used in medicine for arrythmia, angina and hypertension as a calcium channel blocker. For the quantitative determination of Ver in dosage forms, the HPLC method is most often used. A convenient alternative to the chromatographic method is potentiometry using a Verselective electrode, which does not require expensive equipment, can be used without separation from the matrix components, which significantly reduces the analysis time, and does not use toxic organic solvents, being a "green", "environmentally friendly" technique. It has been established in this study that the rational choice of the membrane plasticizer and the preconditioning and measurement algorithms, which prevent nonexchangeable extraction of Ver into the membrane phase, makes it possible to achieve excellent analytical characteristics of Ver-selective electrodes based on commercially available components. In particular, an electrode with the following membrane composition: PVC (32.8 wt %), ortho-nitrophenyloctyl ether (66.6 wt %), and tetrakis-4-chlorophenylborate (0.6 wt % or 0.01 M) have the lower detection limit 4 × 10−8 M and potential reproducibility 0.15–0.22 mV. Both direct potentiometry (DP) and potentiometric titration (PT) methods can be used for the determination of Ver in tablets and injection solutions. Masses of Ver per average tablet weight determined by the methods of DP and PT for the same set of 10 tablets were (80.4±0.2 and80.7±0.2) mg, respectively. The masses of Ver in solutions for injection, determined by DP for two ampoules from one set, were (5.00±0.015 and 5.004±0.006) mg. In all cases, good reproducibility and excellent correspondence with the declared quantities were observed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=verapamil" title="verapamil">verapamil</a>, <a href="https://publications.waset.org/abstracts/search?q=potentiometry" title=" potentiometry"> potentiometry</a>, <a href="https://publications.waset.org/abstracts/search?q=ion-selective%20electrode" title=" ion-selective electrode"> ion-selective electrode</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceutical%20analysis" title=" pharmaceutical analysis"> pharmaceutical analysis</a> </p> <a href="https://publications.waset.org/abstracts/154793/determination-of-verapamil-hydrochloride-in-tablets-and-injection-solutions-with-the-verapamil-selective-electrode-and-possibilities-of-application-in-pharmaceutical-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154793.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">88</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets&page=5">5</a></li> <li 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