CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Domagoj Vucic - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="HOHNDs03uRnk5M4bTsh+n6RNoitcKDxqhaUIrPXLzJ025H13DdIRGJ1f18dzIF793ulshMJIlxl1JfeNTemHRQ==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-1c712297ae3ac71207193b1bae0ecf1aae125886850f62c9c0139dd867630797.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="domagoj vucic" /> <meta name="description" content="Domagoj Vucic: 16 Followers, 8 Following, 129 Research papers. Research interest: Translational Oncology." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15275,"monthly_visitors":"113 million","monthly_visitor_count":113468711,"monthly_visitor_count_in_millions":113,"user_count":277141579,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732405793000); window.Aedu.timeDifference = new Date().getTime() - 1732405793000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-296162c7af6fd81dcdd76f1a94f1fad04fb5f647401337d136fe8b68742170b1.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-8d53a22151f33ab413d88fa1c02f979c3f8706d470fc1bced09852c72a9f3454.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-f8fe82512740391f81c9e8cc48220144024b425b359b08194e316f4de070b9e8.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/DomagojVucic" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-9601d1cc3d68aa07c0a9901d03d3611aec04cc07d2a2039718ebef4ad4d148ca.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":1561679,"name":"Translational Oncology","url":"https://www.academia.edu/Documents/in/Translational_Oncology"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/DomagojVucic","location":"/DomagojVucic","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/DomagojVucic","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-a66215df-328a-4c70-a078-3ac6d4560187"></div> <div id="ProfileCheckPaperUpdate-react-component-a66215df-328a-4c70-a078-3ac6d4560187"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Domagoj Vucic</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Domagoj" data-follow-user-id="33147969" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="33147969"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">16</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">8</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">6</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33147969" href="https://www.academia.edu/Documents/in/Translational_Oncology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/DomagojVucic","location":"/DomagojVucic","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/DomagojVucic","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Translational Oncology"]}" data-trace="false" data-dom-id="Pill-react-component-fe1cde95-614b-4464-a8e9-502be20fe901"></div> <div id="Pill-react-component-fe1cde95-614b-4464-a8e9-502be20fe901"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Domagoj Vucic</h3></div><div class="js-work-strip profile--work_container" data-work-id="115797130"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797130/Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://attachments.academia-assets.com/112103601/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797130/Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, May 1, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4a15c4c6f67ad54d44b08e400bcab337" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103601,"asset_id":115797130,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103601/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797130"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797130"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797130; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797130]").text(description); $(".js-view-count[data-work-id=115797130]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797130; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797130']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797130, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4a15c4c6f67ad54d44b08e400bcab337" } } $('.js-work-strip[data-work-id=115797130]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797130,"title":"Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"publisher":"American Association for Cancer Research","publication_date":{"day":1,"month":5,"year":2008,"errors":{}},"publication_name":"Cancer Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797130/Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:36.923-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103601,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103601/thumbnails/1.jpg","file_name":"3124.pdf","download_url":"https://www.academia.edu/attachments/112103601/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Microphthalmia_Associated_Transcription.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103601/3124-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DMicrophthalmia_Associated_Transcription.pdf\u0026Expires=1732409392\u0026Signature=BONHywxpcgrQ3pQZS~zvtYUeZlUM4ZxaSZVtf6nsov3Uup9zluUHBMQNIJ4JRN7yIMx9ZKYuAsKFYU4CimPqjD~Y2D~L3hfRURdTKUq9mjs6PjyrCz102HIlaO8RHSve9NJJl3YjINJVRwRkp884Wnss-UXdtnCEa0UQwWFlpwdmP5qYIvJA3pCQ0JnFWwL3Yq0NTAIbhb3YTAWp47HMHxnJnAuqIh5SshZ7cMaXinaGG-O3dGRZLRvoCbc1OXtDMB8Onh9G44j~dPSQOD~fGMken0cShR42oo5oBXmAgZn4L5NJL45N8eTXIPAhjyhSEajmy5DLqH9Mm6UkECAq~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103601,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103601/thumbnails/1.jpg","file_name":"3124.pdf","download_url":"https://www.academia.edu/attachments/112103601/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Microphthalmia_Associated_Transcription.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103601/3124-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DMicrophthalmia_Associated_Transcription.pdf\u0026Expires=1732409392\u0026Signature=BONHywxpcgrQ3pQZS~zvtYUeZlUM4ZxaSZVtf6nsov3Uup9zluUHBMQNIJ4JRN7yIMx9ZKYuAsKFYU4CimPqjD~Y2D~L3hfRURdTKUq9mjs6PjyrCz102HIlaO8RHSve9NJJl3YjINJVRwRkp884Wnss-UXdtnCEa0UQwWFlpwdmP5qYIvJA3pCQ0JnFWwL3Yq0NTAIbhb3YTAWp47HMHxnJnAuqIh5SshZ7cMaXinaGG-O3dGRZLRvoCbc1OXtDMB8Onh9G44j~dPSQOD~fGMken0cShR42oo5oBXmAgZn4L5NJL45N8eTXIPAhjyhSEajmy5DLqH9Mm6UkECAq~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10937,"name":"Transcription Regulation","url":"https://www.academia.edu/Documents/in/Transcription_Regulation"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"}],"urls":[{"id":40039187,"url":"https://doi.org/10.1158/0008-5472.can-07-6622"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797129"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797129/Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs"><img alt="Research paper thumbnail of Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs" class="work-thumbnail" src="https://attachments.academia-assets.com/112103600/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797129/Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs">Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs</a></div><div class="wp-workCard_item"><span>ACS Chemical Biology</span><span>, Sep 1, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="db076ac51b200c6de59c84842aa472a7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103600,"asset_id":115797129,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103600/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797129"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797129"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797129; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797129]").text(description); $(".js-view-count[data-work-id=115797129]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797129; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797129']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797129, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "db076ac51b200c6de59c84842aa472a7" } } $('.js-work-strip[data-work-id=115797129]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797129,"title":"Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs","translated_title":"","metadata":{"publisher":"American Chemical Society","publication_date":{"day":1,"month":9,"year":2006,"errors":{}},"publication_name":"ACS Chemical Biology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797129/Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_internal_url":"","created_at":"2024-03-04T19:10:36.727-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103600/thumbnails/1.jpg","file_name":"j.bmcl.2005.04.00220240305-1-8t0bk7.pdf","download_url":"https://www.academia.edu/attachments/112103600/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Design_Synthesis_and_Biological_Activity.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103600/j.bmcl.2005.04.00220240305-1-8t0bk7-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DDesign_Synthesis_and_Biological_Activity.pdf\u0026Expires=1732409392\u0026Signature=Q0g34teMG~19DzSl8TYGKmR-JijRLsA-doBaA1E8MMo~9-b1gul6RDwj4FGMvPyGFncqPQSVZ6DGvL4u8-kTdq3ywqrWzEWIhcQORr4~ENbFV0LVs~jCwXfG5U~axloAFY8UdNEKwROWt8Su6Sjpm-EwgW6jA3Xmrt4GhCtfIjE6KgFWBXRfl0kcUxslYQSbzVMhrs7E33Du9R8Eq98AtPxH2a41tOUwCTfqOprGzetVminV5XOK3OfbaH7jWXxutQt4BTNSByDW8bzJ9ygwJDw4BT9WJaAqLbxduPM356q5QjHuQK6U9AzCAXt-WNglgJL4DV7RhjUKySKHJ3B4VQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103600/thumbnails/1.jpg","file_name":"j.bmcl.2005.04.00220240305-1-8t0bk7.pdf","download_url":"https://www.academia.edu/attachments/112103600/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Design_Synthesis_and_Biological_Activity.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103600/j.bmcl.2005.04.00220240305-1-8t0bk7-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DDesign_Synthesis_and_Biological_Activity.pdf\u0026Expires=1732409392\u0026Signature=Q0g34teMG~19DzSl8TYGKmR-JijRLsA-doBaA1E8MMo~9-b1gul6RDwj4FGMvPyGFncqPQSVZ6DGvL4u8-kTdq3ywqrWzEWIhcQORr4~ENbFV0LVs~jCwXfG5U~axloAFY8UdNEKwROWt8Su6Sjpm-EwgW6jA3Xmrt4GhCtfIjE6KgFWBXRfl0kcUxslYQSbzVMhrs7E33Du9R8Eq98AtPxH2a41tOUwCTfqOprGzetVminV5XOK3OfbaH7jWXxutQt4BTNSByDW8bzJ9ygwJDw4BT9WJaAqLbxduPM356q5QjHuQK6U9AzCAXt-WNglgJL4DV7RhjUKySKHJ3B4VQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":33441,"name":"Macromolecular X-Ray Crystallography","url":"https://www.academia.edu/Documents/in/Macromolecular_X-Ray_Crystallography"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":392067,"name":"Biomimetic materials","url":"https://www.academia.edu/Documents/in/Biomimetic_materials"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":1010725,"name":"Protein Binding","url":"https://www.academia.edu/Documents/in/Protein_Binding"},{"id":2486873,"name":"Inhibitor of apoptosis proteins","url":"https://www.academia.edu/Documents/in/Inhibitor_of_apoptosis_proteins"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":40039186,"url":"https://doi.org/10.1021/cb600276q"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797128"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797128/Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs"><img alt="Research paper thumbnail of Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797128/Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs">Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB, JNK and p38 MAPK signaling pathways is innermost activity of TNF receptor protein signaling complexes that is important for proper function of the immune system. However, excessive activation of these signaling pathways may result in tumor development and progression. Therefore, elucidation of the detailed molecular mechanisms of TNF receptor signaling should gain advantage in our understanding of the tumor biology and invention of the novel anticancer therapies. The formation of TNF receptor complexes, as well structural and functional associations between different signaling molecules is regulated by ubiquitination in TRAF-dependent fashion. TNF receptors employ several proteins possessing ubiquitin E3 ligase activities including cellular Inhibitor of Apoptosis, c-IAP1 and c-IAP2 proteins. We demonstrate that c-IAPs are required for canonical NF-kB and MAPK activation by TNF receptors. By regulating the recruitment of Nemo, IKK2 and HOIP to TNFR signaling complexes c-IAPs promote induction of gene expression by TNF ligands. We also found that TNF receptors that stimulate the noncanonical NF-kB pathway trigger c-IAPs, TRAF2 and TRAF3 intracellular translocation followed by their proteasomal and lysosomal degradation. Finally, we establish that BR3-induced cytosolic depletion of TRAF3 results in noncanonical NF-κB activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2151. doi:1538-7445.AM2012-2151</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797128"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797128"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797128; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797128]").text(description); $(".js-view-count[data-work-id=115797128]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797128; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797128']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797128, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797128]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797128,"title":"Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs","translated_title":"","metadata":{"abstract":"Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB, JNK and p38 MAPK signaling pathways is innermost activity of TNF receptor protein signaling complexes that is important for proper function of the immune system. However, excessive activation of these signaling pathways may result in tumor development and progression. Therefore, elucidation of the detailed molecular mechanisms of TNF receptor signaling should gain advantage in our understanding of the tumor biology and invention of the novel anticancer therapies. The formation of TNF receptor complexes, as well structural and functional associations between different signaling molecules is regulated by ubiquitination in TRAF-dependent fashion. TNF receptors employ several proteins possessing ubiquitin E3 ligase activities including cellular Inhibitor of Apoptosis, c-IAP1 and c-IAP2 proteins. We demonstrate that c-IAPs are required for canonical NF-kB and MAPK activation by TNF receptors. By regulating the recruitment of Nemo, IKK2 and HOIP to TNFR signaling complexes c-IAPs promote induction of gene expression by TNF ligands. We also found that TNF receptors that stimulate the noncanonical NF-kB pathway trigger c-IAPs, TRAF2 and TRAF3 intracellular translocation followed by their proteasomal and lysosomal degradation. Finally, we establish that BR3-induced cytosolic depletion of TRAF3 results in noncanonical NF-κB activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2151. doi:1538-7445.AM2012-2151","publication_date":{"day":15,"month":4,"year":2012,"errors":{}}},"translated_abstract":"Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB, JNK and p38 MAPK signaling pathways is innermost activity of TNF receptor protein signaling complexes that is important for proper function of the immune system. However, excessive activation of these signaling pathways may result in tumor development and progression. Therefore, elucidation of the detailed molecular mechanisms of TNF receptor signaling should gain advantage in our understanding of the tumor biology and invention of the novel anticancer therapies. The formation of TNF receptor complexes, as well structural and functional associations between different signaling molecules is regulated by ubiquitination in TRAF-dependent fashion. TNF receptors employ several proteins possessing ubiquitin E3 ligase activities including cellular Inhibitor of Apoptosis, c-IAP1 and c-IAP2 proteins. We demonstrate that c-IAPs are required for canonical NF-kB and MAPK activation by TNF receptors. By regulating the recruitment of Nemo, IKK2 and HOIP to TNFR signaling complexes c-IAPs promote induction of gene expression by TNF ligands. We also found that TNF receptors that stimulate the noncanonical NF-kB pathway trigger c-IAPs, TRAF2 and TRAF3 intracellular translocation followed by their proteasomal and lysosomal degradation. Finally, we establish that BR3-induced cytosolic depletion of TRAF3 results in noncanonical NF-κB activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2151. doi:1538-7445.AM2012-2151","internal_url":"https://www.academia.edu/115797128/Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs","translated_internal_url":"","created_at":"2024-03-04T19:10:36.505-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor"}],"urls":[{"id":40039185,"url":"https://doi.org/10.1158/1538-7445.am2012-2151"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797127"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797127/The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer"><img alt="Research paper thumbnail of The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/112103581/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797127/The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer">The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer</a></div><div class="wp-workCard_item"><span>Clinical Cancer Research</span><span>, Oct 15, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7a206cfdf5f2f01f61c32ac3376544e8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103581,"asset_id":115797127,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103581/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797127"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797127"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797127; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797127]").text(description); $(".js-view-count[data-work-id=115797127]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797127; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797127']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797127, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7a206cfdf5f2f01f61c32ac3376544e8" } } $('.js-work-strip[data-work-id=115797127]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797127,"title":"The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer","translated_title":"","metadata":{"publisher":"American Association for Cancer Research","publication_date":{"day":15,"month":10,"year":2007,"errors":{}},"publication_name":"Clinical Cancer Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797127/The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer","translated_internal_url":"","created_at":"2024-03-04T19:10:36.315-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103581,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103581/thumbnails/1.jpg","file_name":"5995.pdf","download_url":"https://www.academia.edu/attachments/112103581/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Inhibitor_of_Apoptosis_Proteins_as_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103581/5995-libre.pdf?1709614402=\u0026response-content-disposition=attachment%3B+filename%3DThe_Inhibitor_of_Apoptosis_Proteins_as_T.pdf\u0026Expires=1732409392\u0026Signature=RWFCc0O0SiwF3X3LdbAskY7g5GT1kpVYCxKsMnvVdJFmEUFq8PEgHQzq32dNQyUjLK3kmVuPka6L57hXo5Z4ID22SjgKQJXB2Kcq9Z-BvP~okG~93kzc3bMl6zTeYAii~iqYHkoPFLxcvpeV5Q~-b~0~prxDZ3M3yxd3hBX12goaAQmevwpNILmNfICsaF-B0EE7w3ynVO6U8PIq983Qu6ywDCtO3LrwgWom998V95ePLEaHNF73iDvuhoXMu909w6Y04zl0cYj2GvZqJMnVqHwY1kQyBKwkp~8Db66P34GwFqfDO4JDElNyC2mrJm-ftYjdCgcQhF4x8mL0S19JYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103581,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103581/thumbnails/1.jpg","file_name":"5995.pdf","download_url":"https://www.academia.edu/attachments/112103581/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Inhibitor_of_Apoptosis_Proteins_as_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103581/5995-libre.pdf?1709614402=\u0026response-content-disposition=attachment%3B+filename%3DThe_Inhibitor_of_Apoptosis_Proteins_as_T.pdf\u0026Expires=1732409392\u0026Signature=RWFCc0O0SiwF3X3LdbAskY7g5GT1kpVYCxKsMnvVdJFmEUFq8PEgHQzq32dNQyUjLK3kmVuPka6L57hXo5Z4ID22SjgKQJXB2Kcq9Z-BvP~okG~93kzc3bMl6zTeYAii~iqYHkoPFLxcvpeV5Q~-b~0~prxDZ3M3yxd3hBX12goaAQmevwpNILmNfICsaF-B0EE7w3ynVO6U8PIq983Qu6ywDCtO3LrwgWom998V95ePLEaHNF73iDvuhoXMu909w6Y04zl0cYj2GvZqJMnVqHwY1kQyBKwkp~8Db66P34GwFqfDO4JDElNyC2mrJm-ftYjdCgcQhF4x8mL0S19JYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103582,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103582/thumbnails/1.jpg","file_name":"5995.pdf","download_url":"https://www.academia.edu/attachments/112103582/download_file","bulk_download_file_name":"The_Inhibitor_of_Apoptosis_Proteins_as_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103582/5995-libre.pdf?1709614403=\u0026response-content-disposition=attachment%3B+filename%3DThe_Inhibitor_of_Apoptosis_Proteins_as_T.pdf\u0026Expires=1732409392\u0026Signature=XhKKO8velBF4NzdK~63jHqcWdBt1KE3n51c43QH5J-fWkhCx45Gwo6wylPZCVeYo8hN0bSYwqqeKkkf~S7jhUF3sXpoIzCm9SoPtoDSulL36LhPAlIqrMCQu0yvjnIIoZaDD10CoFP5~IbvbAZk2ENfIi8P1I9PTvhQN11eAoTpI8xE-~vlplpZrQpb-QtrQvzlq~msIYWnCxZKEX5cNco1YgHpAzqKmsIFjSlFerk-iEk-btOeMNK6GX1faOTtxpsDM2bsTZ4ILgli9G5b1CBDf~qu71SccQNwSFJVlMY33kJfUTKLhGdnTBAZ~~XkoXnkaD6P0IYkJXlA8mV2nmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"}],"urls":[{"id":40039184,"url":"https://aacrjournals.org/clincancerres/article-pdf/13/20/5995/1972371/5995.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797126/Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Figure 1 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://attachments.academia-assets.com/112103585/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797126/Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Figure 1 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9b26652c72ee33e48ff7db84c2961e98" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103585,"asset_id":115797126,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103585/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797126; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797126]").text(description); $(".js-view-count[data-work-id=115797126]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797126; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797126']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797126, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9b26652c72ee33e48ff7db84c2961e98" } } $('.js-work-strip[data-work-id=115797126]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797126,"title":"Supplementary Figure 1 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797126/Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:36.039-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103585,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103585/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_1.pdf","download_url":"https://www.academia.edu/attachments/112103585/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_1_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103585/00085472can076622-sup-sfig_1-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=eG7mMtzHmywljMXr88nnbo6JSks-Nk5IR~VkHAZ33ftV~PasUPN5Q6xiQ-NrWsMiIz9U6-eZcnRb3uJhQWEZ5hdb8xU-fS-8TsjwWiFMUESMSJwalNf2~sVYwxA0v~ct3hbAzh9h2355LfgFR-j1nWREMkKUN~mlzCw-lVQeTxmYz5h4S~VkVeOT0ij~4SIbJRV8FnJeymOekgPkqZAWHonkEbwbDsTQO2inOEG6FI5YC-fJG7jdT1U8l3yPfvOvvwMV72AxjE0aZ~yj8shD9fTbAC~WLvsMeuU9qc4FzU0NX6wwteeE3UA-m4pVgD3D163bRg-4sC5vDGcgIfuLew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103585,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103585/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_1.pdf","download_url":"https://www.academia.edu/attachments/112103585/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_1_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103585/00085472can076622-sup-sfig_1-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=eG7mMtzHmywljMXr88nnbo6JSks-Nk5IR~VkHAZ33ftV~PasUPN5Q6xiQ-NrWsMiIz9U6-eZcnRb3uJhQWEZ5hdb8xU-fS-8TsjwWiFMUESMSJwalNf2~sVYwxA0v~ct3hbAzh9h2355LfgFR-j1nWREMkKUN~mlzCw-lVQeTxmYz5h4S~VkVeOT0ij~4SIbJRV8FnJeymOekgPkqZAWHonkEbwbDsTQO2inOEG6FI5YC-fJG7jdT1U8l3yPfvOvvwMV72AxjE0aZ~yj8shD9fTbAC~WLvsMeuU9qc4FzU0NX6wwteeE3UA-m4pVgD3D163bRg-4sC5vDGcgIfuLew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"},{"id":3830245,"name":"Microphthalmia","url":"https://www.academia.edu/Documents/in/Microphthalmia"}],"urls":[{"id":40039183,"url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Microphthalmia-Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas/22375457/1/files/39820739.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797125/Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797125/Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797125]").text(description); $(".js-view-count[data-work-id=115797125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797125,"title":"Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"abstract":"Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":"Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","internal_url":"https://www.academia.edu/115797125/Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:35.822-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"},{"id":3830245,"name":"Microphthalmia","url":"https://www.academia.edu/Documents/in/Microphthalmia"}],"urls":[{"id":40039182,"url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Microphthalmia-Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas/22375451/1/files/39820733.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797124"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797124/Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Figure 2 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://attachments.academia-assets.com/112103584/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797124/Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Figure 2 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9896ffacd96aacc7832a0a244d0fc90d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103584,"asset_id":115797124,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103584/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797124"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797124"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797124; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797124]").text(description); $(".js-view-count[data-work-id=115797124]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797124; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797124']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797124, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9896ffacd96aacc7832a0a244d0fc90d" } } $('.js-work-strip[data-work-id=115797124]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797124,"title":"Supplementary Figure 2 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797124/Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:35.590-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103584,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103584/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_2.pdf","download_url":"https://www.academia.edu/attachments/112103584/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_2_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103584/00085472can076622-sup-sfig_2-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=F9Q-70HQsfMUiws~ID3Szt8KGgxuvfgAzeNWCEWSf8JuVVKT0CJg-3uO12z46JihIJHa3pXw5awLG3F4VKbX0Tb-DGrFu9g0DvTTVAfwK1G7KQYBmxuyz7CzQLD6wt2YCANExpejVOLqLtTX7NAqmb6hqXsaIrmQSOr9dSLBRQlY0zXbnSoGsAqDEle2U5Dj7TgUfERJk~NhEBZRblZxMI9Ow6jlAsECIHizhkkwDghg77H1696H5wTmjXK0EvqFKMNgNKEy2A74GI9-Vq~vkX-awXWu1XBOdL-kiX9StUUZIDi4IAP99SfF3W8CmJDGJQEse8ptD2VpFCgTtEHnhQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103584,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103584/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_2.pdf","download_url":"https://www.academia.edu/attachments/112103584/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_2_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103584/00085472can076622-sup-sfig_2-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=F9Q-70HQsfMUiws~ID3Szt8KGgxuvfgAzeNWCEWSf8JuVVKT0CJg-3uO12z46JihIJHa3pXw5awLG3F4VKbX0Tb-DGrFu9g0DvTTVAfwK1G7KQYBmxuyz7CzQLD6wt2YCANExpejVOLqLtTX7NAqmb6hqXsaIrmQSOr9dSLBRQlY0zXbnSoGsAqDEle2U5Dj7TgUfERJk~NhEBZRblZxMI9Ow6jlAsECIHizhkkwDghg77H1696H5wTmjXK0EvqFKMNgNKEy2A74GI9-Vq~vkX-awXWu1XBOdL-kiX9StUUZIDi4IAP99SfF3W8CmJDGJQEse8ptD2VpFCgTtEHnhQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103583,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103583/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_2.pdf","download_url":"https://www.academia.edu/attachments/112103583/download_file","bulk_download_file_name":"Supplementary_Figure_2_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103583/00085472can076622-sup-sfig_2-libre.pdf?1709614398=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=VBhbLYIumVCao9r6yL6cdGxLH3v930S02xqZO21qv6Keai1MLzR90cDPATL8TbUpFJRt2ywlfM2mL2k0MDVffnudBLrgc0D6KB~3nqo-lifS1MF6GL-yYDpKtvYolCvfsxWndimsMvTkZk39pC5ZOCYsyKsGMSA00LwBhN-HbXkcLlNdToY-Kz44K3N6RCFFN4sanWHSKdDctLcuKz8EGbqfpXHbg5Bi7VtJ17in1JXGZ2nI-GBL5rU-MMHIms-XeUcn5owUnm8sVs3NAGpr28nhHOuNv3TMWCwe7j7JWr~fVHTaa~TInnZKbdytKZMFnOodj8zi9weMt8Jx7boWHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"},{"id":3830245,"name":"Microphthalmia","url":"https://www.academia.edu/Documents/in/Microphthalmia"}],"urls":[{"id":40039181,"url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Microphthalmia-Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas/22375454/1/files/39820736.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797123"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797123/Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Data from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797123/Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Data from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells. The ML-IAP promoter contains two MITF consensus sites, and analysis of MITF and ML-IAP mRNA levels revealed a high correlation in melanoma tumor samples and cell lines. In reporter assays, MITF promoted a strong stimulation of transcriptional activity from the ML-IAP promoter, and MITF bound the endogenous ML-IAP promoter in melanoma cells by chromatin immunoprecipitation and electrophoretic mobility shift assay. Strikingly, small interfering RNA (siRNA)–mediated knockdown of MITF in melanoma cells led to a dramatic decrease in ML-IAP mRNA and protein levels, establishing that ML-IAP expression in melanoma cells is MITF dependent. Additionally, cyclic AMP–mediated induction of MITF expression in melanocytes resulted in increased ML-IAP expression, suggesting that melanocytes can express ML-IAP when MITF levels are heightened. Disruption of MITF by siRNA led to a decrease in melanoma cell viability, which could be rescued by ectopic expression of ML-IAP. Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. [Cancer Res 2008;68(9):3124–32]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797123"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797123]").text(description); $(".js-view-count[data-work-id=115797123]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797123']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797123, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797123]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797123,"title":"Data from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"abstract":"Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells. The ML-IAP promoter contains two MITF consensus sites, and analysis of MITF and ML-IAP mRNA levels revealed a high correlation in melanoma tumor samples and cell lines. In reporter assays, MITF promoted a strong stimulation of transcriptional activity from the ML-IAP promoter, and MITF bound the endogenous ML-IAP promoter in melanoma cells by chromatin immunoprecipitation and electrophoretic mobility shift assay. Strikingly, small interfering RNA (siRNA)–mediated knockdown of MITF in melanoma cells led to a dramatic decrease in ML-IAP mRNA and protein levels, establishing that ML-IAP expression in melanoma cells is MITF dependent. Additionally, cyclic AMP–mediated induction of MITF expression in melanocytes resulted in increased ML-IAP expression, suggesting that melanocytes can express ML-IAP when MITF levels are heightened. Disruption of MITF by siRNA led to a decrease in melanoma cell viability, which could be rescued by ectopic expression of ML-IAP. Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. [Cancer Res 2008;68(9):3124–32]","publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":"Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells. The ML-IAP promoter contains two MITF consensus sites, and analysis of MITF and ML-IAP mRNA levels revealed a high correlation in melanoma tumor samples and cell lines. In reporter assays, MITF promoted a strong stimulation of transcriptional activity from the ML-IAP promoter, and MITF bound the endogenous ML-IAP promoter in melanoma cells by chromatin immunoprecipitation and electrophoretic mobility shift assay. Strikingly, small interfering RNA (siRNA)–mediated knockdown of MITF in melanoma cells led to a dramatic decrease in ML-IAP mRNA and protein levels, establishing that ML-IAP expression in melanoma cells is MITF dependent. Additionally, cyclic AMP–mediated induction of MITF expression in melanocytes resulted in increased ML-IAP expression, suggesting that melanocytes can express ML-IAP when MITF levels are heightened. Disruption of MITF by siRNA led to a decrease in melanoma cell viability, which could be rescued by ectopic expression of ML-IAP. Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. [Cancer Res 2008;68(9):3124–32]","internal_url":"https://www.academia.edu/115797123/Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:35.374-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"}],"urls":[{"id":40039180,"url":"https://doi.org/10.1158/0008-5472.c.6497828"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797122/Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs"><img alt="Research paper thumbnail of Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797122/Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs">Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs</a></div><div class="wp-workCard_item"><span>ACS Chemical Biology</span><span>, Oct 1, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797122]").text(description); $(".js-view-count[data-work-id=115797122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797122, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797122]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797122,"title":"Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs","translated_title":"","metadata":{"abstract":"Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML ...","publisher":"American Chemical Society","publication_date":{"day":1,"month":10,"year":2006,"errors":{}},"publication_name":"ACS Chemical Biology"},"translated_abstract":"Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML ...","internal_url":"https://www.academia.edu/115797122/Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_internal_url":"","created_at":"2024-03-04T19:10:35.112-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":12981,"name":"Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Enzyme_Inhibitors"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":199319,"name":"Citation","url":"https://www.academia.edu/Documents/in/Citation"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":392067,"name":"Biomimetic materials","url":"https://www.academia.edu/Documents/in/Biomimetic_materials"},{"id":463081,"name":"Acetylation","url":"https://www.academia.edu/Documents/in/Acetylation"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":901298,"name":"Glucose Tolerance Test","url":"https://www.academia.edu/Documents/in/Glucose_Tolerance_Test"},{"id":2486873,"name":"Inhibitor of apoptosis proteins","url":"https://www.academia.edu/Documents/in/Inhibitor_of_apoptosis_proteins"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3004151,"name":"CHO cells","url":"https://www.academia.edu/Documents/in/CHO_cells"},{"id":3214915,"name":"Cricetinae","url":"https://www.academia.edu/Documents/in/Cricetinae"}],"urls":[{"id":40039179,"url":"https://doi.org/10.1021/cb6004195"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797121/Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling"><img alt="Research paper thumbnail of Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling" class="work-thumbnail" src="https://attachments.academia-assets.com/112103599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797121/Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling">Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling</a></div><div class="wp-workCard_item"><span>Molecular Cell</span><span>, Feb 1, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef2fdccf2bf104b332ba5f947b79d34c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103599,"asset_id":115797121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103599/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797121]").text(description); $(".js-view-count[data-work-id=115797121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797121, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef2fdccf2bf104b332ba5f947b79d34c" } } $('.js-work-strip[data-work-id=115797121]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797121,"title":"Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":1,"month":2,"year":2018,"errors":{}},"publication_name":"Molecular Cell"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797121/Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling","translated_internal_url":"","created_at":"2024-03-04T19:10:34.923-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103599/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/112103599/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Disruption_of_XIAP_RIP2_Association_Bloc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103599/pdf-libre.pdf?1709614994=\u0026response-content-disposition=attachment%3B+filename%3DDisruption_of_XIAP_RIP2_Association_Bloc.pdf\u0026Expires=1732409392\u0026Signature=YT1NJ3~PsggvFuyIFc1Db1NKG18ugIM8jp-bEracITO1gncMwjq~QpyEICpCarN5MMI4QIedvcXBast8rC5GUTfaNwcfeVCbjgnm5kZcGZtVPhbA~xxSXaB7AVRicGui7gmI5x0Iz~E8qkNAgNsxEG-NgQb2TEGv1E9glqS1Otkvkj-0g8j3KanowerpvmE1gVWeTV~xfRMQ~Vr9DyRRAfys3jYSZu6vRWYbcFloi22rMSveT75XVgb3jI0LIisNKXwitfq6Tp-DoXPDE4pEhqWQ7EiQEhXcRIeQyyjI1m11IE~-z5SwJGY5OhpqKt9~J7bFXVcQ~GPHsi6VzYEyAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling","translated_slug":"","page_count":23,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103599/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/112103599/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Disruption_of_XIAP_RIP2_Association_Bloc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103599/pdf-libre.pdf?1709614994=\u0026response-content-disposition=attachment%3B+filename%3DDisruption_of_XIAP_RIP2_Association_Bloc.pdf\u0026Expires=1732409392\u0026Signature=YT1NJ3~PsggvFuyIFc1Db1NKG18ugIM8jp-bEracITO1gncMwjq~QpyEICpCarN5MMI4QIedvcXBast8rC5GUTfaNwcfeVCbjgnm5kZcGZtVPhbA~xxSXaB7AVRicGui7gmI5x0Iz~E8qkNAgNsxEG-NgQb2TEGv1E9glqS1Otkvkj-0g8j3KanowerpvmE1gVWeTV~xfRMQ~Vr9DyRRAfys3jYSZu6vRWYbcFloi22rMSveT75XVgb3jI0LIisNKXwitfq6Tp-DoXPDE4pEhqWQ7EiQEhXcRIeQyyjI1m11IE~-z5SwJGY5OhpqKt9~J7bFXVcQ~GPHsi6VzYEyAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":46578,"name":"Cell and Molecular Biology","url":"https://www.academia.edu/Documents/in/Cell_and_Molecular_Biology"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"},{"id":3135141,"name":"nod","url":"https://www.academia.edu/Documents/in/nod"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":40039178,"url":"https://doi.org/10.1016/j.molcel.2018.01.016"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797120"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797120/Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold"><img alt="Research paper thumbnail of Antagonists of IAP proteins based on an azabicyclooctane scaffold" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797120/Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold">Antagonists of IAP proteins based on an azabicyclooctane scaffold</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, May 1, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was used to design potential proline mimetics. The synthesis of an azabicyclooctane core, and incorporation of this core into elaborated antagonists is described. The binding of these compounds to IAP proteins was assessed by fluorescence polarization competition assay, and several compounds with Kis of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797120"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797120]").text(description); $(".js-view-count[data-work-id=115797120]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797120']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797120, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797120]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797120,"title":"Antagonists of IAP proteins based on an azabicyclooctane scaffold","translated_title":"","metadata":{"abstract":"4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was used to design potential proline mimetics. The synthesis of an azabicyclooctane core, and incorporation of this core into elaborated antagonists is described. The binding of these compounds to IAP proteins was assessed by fluorescence polarization competition assay, and several compounds with Kis of","publisher":"American Association for Cancer Research","publication_date":{"day":1,"month":5,"year":2007,"errors":{}},"publication_name":"Cancer Research"},"translated_abstract":"4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was used to design potential proline mimetics. The synthesis of an azabicyclooctane core, and incorporation of this core into elaborated antagonists is described. The binding of these compounds to IAP proteins was assessed by fluorescence polarization competition assay, and several compounds with Kis of","internal_url":"https://www.academia.edu/115797120/Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold","translated_internal_url":"","created_at":"2024-03-04T19:10:34.732-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"}],"urls":[{"id":40039177,"url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/4736"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797119"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797119/Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023"><img alt="Research paper thumbnail of Apoptotic cell death in disease—Current understanding of the NCCD 2023" class="work-thumbnail" src="https://attachments.academia-assets.com/112103580/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797119/Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023">Apoptotic cell death in disease—Current understanding of the NCCD 2023</a></div><div class="wp-workCard_item"><span>Cell Death &amp; Differentiation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c50ba54e0c490d80350d2d2f63ce3a7c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103580,"asset_id":115797119,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103580/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797119"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797119"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797119; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797119]").text(description); $(".js-view-count[data-work-id=115797119]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797119; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797119']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797119, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c50ba54e0c490d80350d2d2f63ce3a7c" } } $('.js-work-strip[data-work-id=115797119]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797119,"title":"Apoptotic cell death in disease—Current understanding of the NCCD 2023","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_name":"Cell Death \u0026amp; Differentiation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797119/Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023","translated_internal_url":"","created_at":"2024-03-04T19:10:34.483-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103580,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103580/thumbnails/1.jpg","file_name":"s41418-023-01153-w.pdf","download_url":"https://www.academia.edu/attachments/112103580/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Apoptotic_cell_death_in_disease_Current.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103580/s41418-023-01153-w-libre.pdf?1709614448=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_cell_death_in_disease_Current.pdf\u0026Expires=1732409392\u0026Signature=FSTfqaTuMlEQ32~DxbobIa6vUHliz0SeEXYZjJ02~5QH52T3I~zknFknR0l0L~xSsTr5D75VM3y03303c83wveYf~y5WVQm7LYJHJo66u8ItdAby3yW1BpBgBrygyJV7f0kjQpv3CHRldjFwEIjYmQneXp43DzeubXVt4E3l~NIvNiLnZawQYtpm2tCzrodC6bEFtIjwy8F6WJyZcC0ZbYUaPceM45NBoZfT8kUoWH-9HlCOgfVepxwvqyvT-dnBkL9bxGXird8r-~PrQIJTKGYVo71t3gdjVod27zf3CDwyfsbyVC7V5wU7YaLtE3z~gGhikOnJBPY4MEvJ8Ys8Uw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023","translated_slug":"","page_count":58,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103580,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103580/thumbnails/1.jpg","file_name":"s41418-023-01153-w.pdf","download_url":"https://www.academia.edu/attachments/112103580/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Apoptotic_cell_death_in_disease_Current.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103580/s41418-023-01153-w-libre.pdf?1709614448=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_cell_death_in_disease_Current.pdf\u0026Expires=1732409392\u0026Signature=FSTfqaTuMlEQ32~DxbobIa6vUHliz0SeEXYZjJ02~5QH52T3I~zknFknR0l0L~xSsTr5D75VM3y03303c83wveYf~y5WVQm7LYJHJo66u8ItdAby3yW1BpBgBrygyJV7f0kjQpv3CHRldjFwEIjYmQneXp43DzeubXVt4E3l~NIvNiLnZawQYtpm2tCzrodC6bEFtIjwy8F6WJyZcC0ZbYUaPceM45NBoZfT8kUoWH-9HlCOgfVepxwvqyvT-dnBkL9bxGXird8r-~PrQIJTKGYVo71t3gdjVod27zf3CDwyfsbyVC7V5wU7YaLtE3z~gGhikOnJBPY4MEvJ8Ys8Uw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103579,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103579/thumbnails/1.jpg","file_name":"s41418-023-01153-w.pdf","download_url":"https://www.academia.edu/attachments/112103579/download_file","bulk_download_file_name":"Apoptotic_cell_death_in_disease_Current.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103579/s41418-023-01153-w-libre.pdf?1709614452=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_cell_death_in_disease_Current.pdf\u0026Expires=1732409392\u0026Signature=WW22vizWllKP4f~Qrcj0VlnTKemdC4zx6n~7r0pY46RoAp49SwKKbCG5VQpbVE0Sz8DI9kr3dB0BahuDLBzCvVD3wtfN7K7FD~EAbmivKXtmYDDAvLW40wP-AvgiEhYcs4ady7e3~6mQmXD0eekrYLf4UeCuPXqdYcSwoqbp0XSWHoh6dvRIjRRzthOIc8APZDVWykjNorPFdt-gDGQpTGBbYmPChYBWrQTO-j7SpviMciAgx9q8LcZaOB4rlWRoa2wZZsODgc1u6cOQTtQvAiDi2m1X05CBLPF3izH6UKAEyqIqeOBti096eb3kTbqUnxYdoB33Zl6F3nF7nQMzvg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis"},{"id":857512,"name":"Proteases","url":"https://www.academia.edu/Documents/in/Proteases"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":40039176,"url":"https://www.nature.com/articles/s41418-023-01153-w.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797118"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797118/RIP1_post_translational_modifications"><img alt="Research paper thumbnail of RIP1 post-translational modifications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797118/RIP1_post_translational_modifications">RIP1 post-translational modifications</a></div><div class="wp-workCard_item"><span>Biochemical Journal</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell dea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797118"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797118"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797118; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797118]").text(description); $(".js-view-count[data-work-id=115797118]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797118; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797118']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797118, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797118]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797118,"title":"RIP1 post-translational modifications","translated_title":"","metadata":{"abstract":"Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, an...","publisher":"Portland Press Ltd.","publication_name":"Biochemical Journal"},"translated_abstract":"Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, an...","internal_url":"https://www.academia.edu/115797118/RIP1_post_translational_modifications","translated_internal_url":"","created_at":"2024-03-04T19:10:34.261-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"RIP1_post_translational_modifications","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":55266,"name":"Ubiquitin","url":"https://www.academia.edu/Documents/in/Ubiquitin"},{"id":172083,"name":"Phosphorylation","url":"https://www.academia.edu/Documents/in/Phosphorylation"},{"id":176525,"name":"Biochemical","url":"https://www.academia.edu/Documents/in/Biochemical"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":1947599,"name":"Autophosphorylation","url":"https://www.academia.edu/Documents/in/Autophosphorylation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":40039175,"url":"https://portlandpress.com/biochemj/article-pdf/479/9/929/932569/bcj-2021-0725c.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797117"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797117/Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd"><img alt="Research paper thumbnail of Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797117/Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd">Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd</a></div><div class="wp-workCard_item"><span>Transplantation and Cellular Therapy</span><span>, Feb 1, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797117"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797117"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797117; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797117]").text(description); $(".js-view-count[data-work-id=115797117]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797117; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797117']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797117, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797117]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797117,"title":"Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd","translated_title":"","metadata":{"publication_date":{"day":1,"month":2,"year":2023,"errors":{}},"publication_name":"Transplantation and Cellular Therapy"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797117/Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd","translated_internal_url":"","created_at":"2024-03-04T19:10:34.053-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[],"urls":[{"id":40039174,"url":"https://doi.org/10.1016/s2666-6367(23)00074-x"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797116"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797116/IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition"><img alt="Research paper thumbnail of IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition" class="work-thumbnail" src="https://attachments.academia-assets.com/112103577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797116/IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition">IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition</a></div><div class="wp-workCard_item"><span>Cell Death &amp; Disease</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f172b0081ef860864b4f5c6595a1d74a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103577,"asset_id":115797116,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103577/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797116"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797116]").text(description); $(".js-view-count[data-work-id=115797116]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797116']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797116, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f172b0081ef860864b4f5c6595a1d74a" } } $('.js-work-strip[data-work-id=115797116]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797116,"title":"IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_name":"Cell Death \u0026amp; Disease"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797116/IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition","translated_internal_url":"","created_at":"2024-03-04T19:10:33.854-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103577,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103577/thumbnails/1.jpg","file_name":"s41419-022-05283-w.pdf","download_url":"https://www.academia.edu/attachments/112103577/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_GDC_0917_is_more_potent_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103577/s41419-022-05283-w-libre.pdf?1709614396=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_GDC_0917_is_more_potent_t.pdf\u0026Expires=1732409392\u0026Signature=eJyBWocWBt~C9k05qL8JDkYYcwmoMVfptl3JQRVkP39fbENPOwN5ZtJbqU580emtR4eyW8xccUKGyQtG8WuKYdOsAPYptfPrgVkw0UNSzem0XuN4GhWpQvTm5olmaDRjBBYD2ewWO~6PViEDa2YvCy92uBaJXyaHlamN8c2r9FnC4Q7ahTzDHKtYxAbNJdgpkpknssQML1fHOhh2kpN6fHiAXWq7~Cqbu~2lDP7gpXfR7d5Y-Akkm-WA5ZjBVKRyWBk9vbLTYZjA6MBcOUCV1geOGkEndPXb1WO0q~fTTnPcuPNvP~YKesyaQ9BO8RrgFujOVc6lNqxmNkHV7Hh~vw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103577,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103577/thumbnails/1.jpg","file_name":"s41419-022-05283-w.pdf","download_url":"https://www.academia.edu/attachments/112103577/download_file?st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_GDC_0917_is_more_potent_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103577/s41419-022-05283-w-libre.pdf?1709614396=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_GDC_0917_is_more_potent_t.pdf\u0026Expires=1732409392\u0026Signature=eJyBWocWBt~C9k05qL8JDkYYcwmoMVfptl3JQRVkP39fbENPOwN5ZtJbqU580emtR4eyW8xccUKGyQtG8WuKYdOsAPYptfPrgVkw0UNSzem0XuN4GhWpQvTm5olmaDRjBBYD2ewWO~6PViEDa2YvCy92uBaJXyaHlamN8c2r9FnC4Q7ahTzDHKtYxAbNJdgpkpknssQML1fHOhh2kpN6fHiAXWq7~Cqbu~2lDP7gpXfR7d5Y-Akkm-WA5ZjBVKRyWBk9vbLTYZjA6MBcOUCV1geOGkEndPXb1WO0q~fTTnPcuPNvP~YKesyaQ9BO8RrgFujOVc6lNqxmNkHV7Hh~vw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103578,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103578/thumbnails/1.jpg","file_name":"s41419-022-05283-w.pdf","download_url":"https://www.academia.edu/attachments/112103578/download_file","bulk_download_file_name":"IAP_antagonist_GDC_0917_is_more_potent_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103578/s41419-022-05283-w-libre.pdf?1709614396=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_GDC_0917_is_more_potent_t.pdf\u0026Expires=1732409392\u0026Signature=aqCttp0gk1NHIIA~mG-4wipm8hK7uJ5zncyRt15kMtd7bt1SS9dMbRPSemJGqVWFIDlmRghxiRi2eNglm2NaLziA2sHqp17RiiUvQ7BvoFEo0HA2YQb8U~GF58UhyDmbu6G4KcO5BsSvn5veZkuNsL~~jl0PEaNXgYWaG-52sF42vjr~edvUATVy6vMslI~qFg8Zdcabt4bTXW-~lqcsH3uRVAJ6scHiEbmkfWlBwL3rduj4EJPXasjNnHQUmMrX0aTgeDHYz4iOs1lZCSLCY3bEBzKfS7rKbbeOibklsBIaATfuxRpb~Tj7tDZu9MGvhPTUk2U~MmIPeUnjM4PO4w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":196060,"name":"Antagonist","url":"https://www.academia.edu/Documents/in/Antagonist"},{"id":1954130,"name":"Cell Growth","url":"https://www.academia.edu/Documents/in/Cell_Growth"}],"urls":[{"id":40039173,"url":"https://www.nature.com/articles/s41419-022-05283-w.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797115/XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration"><img alt="Research paper thumbnail of XIAP promotes melanoma growth by inducing tumour neutrophil infiltration" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797115/XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration">XIAP promotes melanoma growth by inducing tumour neutrophil infiltration</a></div><div class="wp-workCard_item"><span>EMBO reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently rep...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti-apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro-inflammatory function of XIAP has not yet been considered in cancer. By providing detailed in vitro analyses, utilising two independent mouse melanoma models and including human melanoma samples, we show here that XIAP is an important mediator of melanoma neutrophil infiltration. Neutrophils represent a major driver of melanoma progression and are increasingly considered as a valuable therapeutic target in solid cancer. Our data reveal that XIAP ubiquitylates RIPK2, involve TAB1/RIPK2 complex and induce the transcriptional up-regulation and secretion of chemokines such as IL8, that are responsible for intra-tumour neutrophil accumulation. Alteration of the XIAP-RIPK2-TAB1 inflammatory axis or the depletion of neutrophils in mice reduced melanoma growth. Our data shed new light on how XIAP contributes to tumour growth and provides important insights for novel XIAP targeting strategies in cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797115]").text(description); $(".js-view-count[data-work-id=115797115]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797115; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797115']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797115, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797115]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797115,"title":"XIAP promotes melanoma growth by inducing tumour neutrophil infiltration","translated_title":"","metadata":{"abstract":"Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti-apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro-inflammatory function of XIAP has not yet been considered in cancer. By providing detailed in vitro analyses, utilising two independent mouse melanoma models and including human melanoma samples, we show here that XIAP is an important mediator of melanoma neutrophil infiltration. Neutrophils represent a major driver of melanoma progression and are increasingly considered as a valuable therapeutic target in solid cancer. Our data reveal that XIAP ubiquitylates RIPK2, involve TAB1/RIPK2 complex and induce the transcriptional up-regulation and secretion of chemokines such as IL8, that are responsible for intra-tumour neutrophil accumulation. Alteration of the XIAP-RIPK2-TAB1 inflammatory axis or the depletion of neutrophils in mice reduced melanoma growth. Our data shed new light on how XIAP contributes to tumour growth and provides important insights for novel XIAP targeting strategies in cancer.","publisher":"EMBO","publication_name":"EMBO reports"},"translated_abstract":"Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti-apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro-inflammatory function of XIAP has not yet been considered in cancer. By providing detailed in vitro analyses, utilising two independent mouse melanoma models and including human melanoma samples, we show here that XIAP is an important mediator of melanoma neutrophil infiltration. Neutrophils represent a major driver of melanoma progression and are increasingly considered as a valuable therapeutic target in solid cancer. Our data reveal that XIAP ubiquitylates RIPK2, involve TAB1/RIPK2 complex and induce the transcriptional up-regulation and secretion of chemokines such as IL8, that are responsible for intra-tumour neutrophil accumulation. Alteration of the XIAP-RIPK2-TAB1 inflammatory axis or the depletion of neutrophils in mice reduced melanoma growth. Our data shed new light on how XIAP contributes to tumour growth and provides important insights for novel XIAP targeting strategies in cancer.","internal_url":"https://www.academia.edu/115797115/XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration","translated_internal_url":"","created_at":"2024-03-04T19:10:33.648-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":295234,"name":"Chemokine","url":"https://www.academia.edu/Documents/in/Chemokine"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[{"id":40039172,"url":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.202153608"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797114"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797114/Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling"><img alt="Research paper thumbnail of Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797114/Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling">Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling</a></div><div class="wp-workCard_item"><span>Encyclopedia of Cell Biology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor of apoptosis or IAP protein family is involved in the control of cell death through a variety of molecular mechanisms. The common aspect of these proteins is the presence of the Baculovirus IAP repeat domain, which is involved in protein–protein interactions with pro-survival and pro-apoptotic proteins. Several IAP proteins also contain a RING domain, which gives them ubiquitin E3 ligase activity and plays a major role in antiapoptotic and pro-survival signaling. Given their importance in regulation of cell survival and signaling, and elevated expression in human malignancies, IAPs are an attractive therapeutic target.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797114"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797114"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797114; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797114]").text(description); $(".js-view-count[data-work-id=115797114]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797114; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797114']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797114, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797114]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797114,"title":"Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling","translated_title":"","metadata":{"abstract":"Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor of apoptosis or IAP protein family is involved in the control of cell death through a variety of molecular mechanisms. The common aspect of these proteins is the presence of the Baculovirus IAP repeat domain, which is involved in protein–protein interactions with pro-survival and pro-apoptotic proteins. Several IAP proteins also contain a RING domain, which gives them ubiquitin E3 ligase activity and plays a major role in antiapoptotic and pro-survival signaling. Given their importance in regulation of cell survival and signaling, and elevated expression in human malignancies, IAPs are an attractive therapeutic target.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Encyclopedia of Cell Biology"},"translated_abstract":"Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor of apoptosis or IAP protein family is involved in the control of cell death through a variety of molecular mechanisms. The common aspect of these proteins is the presence of the Baculovirus IAP repeat domain, which is involved in protein–protein interactions with pro-survival and pro-apoptotic proteins. Several IAP proteins also contain a RING domain, which gives them ubiquitin E3 ligase activity and plays a major role in antiapoptotic and pro-survival signaling. Given their importance in regulation of cell survival and signaling, and elevated expression in human malignancies, IAPs are an attractive therapeutic target.","internal_url":"https://www.academia.edu/115797114/Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling","translated_internal_url":"","created_at":"2024-03-04T19:10:32.497-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":55266,"name":"Ubiquitin","url":"https://www.academia.edu/Documents/in/Ubiquitin"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797094"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797094/IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization"><img alt="Research paper thumbnail of IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization" class="work-thumbnail" src="https://attachments.academia-assets.com/112103588/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797094/IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization">IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1b8d7c39d291ce55b08b65bd98b82cd5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103588,"asset_id":115797094,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103588/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797094"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797094"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797094; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797094]").text(description); $(".js-view-count[data-work-id=115797094]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797094; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797094']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797094, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1b8d7c39d291ce55b08b65bd98b82cd5" } } $('.js-work-strip[data-work-id=115797094]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797094,"title":"IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization","translated_title":"","metadata":{"publisher":"Worldwide Protein Data Bank","publication_date":{"day":null,"month":null,"year":2011,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797094/IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization","translated_internal_url":"","created_at":"2024-03-04T19:09:43.471-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103588,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103588/thumbnails/1.jpg","file_name":"3t6p_full_validation.pdf","download_url":"https://www.academia.edu/attachments/112103588/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_induced_conformational_ch.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103588/3t6p_full_validation-libre.pdf?1709614416=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_induced_conformational_ch.pdf\u0026Expires=1732409392\u0026Signature=AzV2og0wlOdeRoIaS8nv6tnr~lCje5Rghwfi-vTq9xrfibHMJwCYfI-5bXrSxrz4JDldNBOlFrz68slQHJVi4fGs6xibhJRoXvLoNlzAby6pNfPgxOl6FjbSKFjR3pMq06fKcZk78kJxh1l0W9QFRRvs2s1bcVy0cnh59MAPI0uvvkRvD0acg81oTmn0VdWzyj4WbfWPNehy6FrPqHNM1uAUC90BtwcHlC2VxpmABHx0z7D1GKizuw1peq4wToy2QIdnJXkAsntfLinfXtg8nDo7LDOYd1-2oxFG1fsKdDYXn1fzUCt8vlHc2x9bX2PC0Y-i5kXRVwfQqO8JePC3DQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103588,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103588/thumbnails/1.jpg","file_name":"3t6p_full_validation.pdf","download_url":"https://www.academia.edu/attachments/112103588/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_induced_conformational_ch.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103588/3t6p_full_validation-libre.pdf?1709614416=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_induced_conformational_ch.pdf\u0026Expires=1732409392\u0026Signature=AzV2og0wlOdeRoIaS8nv6tnr~lCje5Rghwfi-vTq9xrfibHMJwCYfI-5bXrSxrz4JDldNBOlFrz68slQHJVi4fGs6xibhJRoXvLoNlzAby6pNfPgxOl6FjbSKFjR3pMq06fKcZk78kJxh1l0W9QFRRvs2s1bcVy0cnh59MAPI0uvvkRvD0acg81oTmn0VdWzyj4WbfWPNehy6FrPqHNM1uAUC90BtwcHlC2VxpmABHx0z7D1GKizuw1peq4wToy2QIdnJXkAsntfLinfXtg8nDo7LDOYd1-2oxFG1fsKdDYXn1fzUCt8vlHc2x9bX2PC0Y-i5kXRVwfQqO8JePC3DQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":196060,"name":"Antagonist","url":"https://www.academia.edu/Documents/in/Antagonist"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"},{"id":784468,"name":"DNA ligase","url":"https://www.academia.edu/Documents/in/DNA_ligase"},{"id":1274450,"name":"Conformational Change","url":"https://www.academia.edu/Documents/in/Conformational_Change"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="109871358"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109871358/Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells"><img alt="Research paper thumbnail of Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells" class="work-thumbnail" src="https://attachments.academia-assets.com/107865025/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109871358/Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells">Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediato...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, lung, and head and neck tumors. PAK1 genomic amplification at 11q13 was prevalent in luminal breast cancer, and PAK1 protein expression was associated with lymph node metastasis. Breast cancer cells with PAK1 genomic amplification rapidly underwent apoptosis after inhibition of this kinase. Strong nuclear and cytoplasmic PAK1 expression was also prevalent in squamous nonsmall cell lung carcinomas (NSCLCs), and selective PAK1 inhibition was associated with delayed cell-cycle progression in vi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a8a8a369a1190987c26d683c3d6a7a92" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107865025,"asset_id":109871358,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107865025/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109871358"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109871358"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109871358; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109871358]").text(description); $(".js-view-count[data-work-id=109871358]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109871358; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109871358']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 109871358, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a8a8a369a1190987c26d683c3d6a7a92" } } $('.js-work-strip[data-work-id=109871358]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109871358,"title":"Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells","translated_title":"","metadata":{"abstract":"p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, lung, and head and neck tumors. PAK1 genomic amplification at 11q13 was prevalent in luminal breast cancer, and PAK1 protein expression was associated with lymph node metastasis. Breast cancer cells with PAK1 genomic amplification rapidly underwent apoptosis after inhibition of this kinase. Strong nuclear and cytoplasmic PAK1 expression was also prevalent in squamous nonsmall cell lung carcinomas (NSCLCs), and selective PAK1 inhibition was associated with delayed cell-cycle progression in vi...","publisher":"Proceedings of the National Academy of Sciences","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Proceedings of the National Academy of Sciences"},"translated_abstract":"p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, lung, and head and neck tumors. PAK1 genomic amplification at 11q13 was prevalent in luminal breast cancer, and PAK1 protein expression was associated with lymph node metastasis. Breast cancer cells with PAK1 genomic amplification rapidly underwent apoptosis after inhibition of this kinase. Strong nuclear and cytoplasmic PAK1 expression was also prevalent in squamous nonsmall cell lung carcinomas (NSCLCs), and selective PAK1 inhibition was associated with delayed cell-cycle progression in vi...","internal_url":"https://www.academia.edu/109871358/Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells","translated_internal_url":"","created_at":"2023-11-26T09:17:48.354-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":107865025,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/107865025/thumbnails/1.jpg","file_name":"0579abddebf80cf012ee7a7a00a448df5ebb.pdf","download_url":"https://www.academia.edu/attachments/107865025/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Targeting_p21_activated_kinase_1_PAK1_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/107865025/0579abddebf80cf012ee7a7a00a448df5ebb-libre.pdf?1701019879=\u0026response-content-disposition=attachment%3B+filename%3DTargeting_p21_activated_kinase_1_PAK1_to.pdf\u0026Expires=1732409393\u0026Signature=XRNby9SmfHljamNPeFci--zgk9cdox8TxfkRIq3Y2vp~3OTDbiEZtuX7wuWPSin0em1-Rtv2O8Pc71qMtvB8u5yjOT~xw4jpVR35VE8LIw9JmZ8xN~qAqiSXvu4gmgsnLX2vtQg8~FZXdFuZDmQJsDkfsLQ9Qb3WfUAbok9wBTZNw1v8i7ZTiSrPRdfrv1dMb3I5dQ0mgyXrXdkuGIBVnOBkFfvp96gUeRxO7hmYxrZekEJ7qnnVhN2cW41xl9NYjYlcK4b6Liep6fwgF1nLXBkK9lI7l7IZJh5dS1c~pkC9P8Ku6ZZAGQ7IfZM2hzlKe2mji9CQ5MpRC7ZakmauuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":107865025,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/107865025/thumbnails/1.jpg","file_name":"0579abddebf80cf012ee7a7a00a448df5ebb.pdf","download_url":"https://www.academia.edu/attachments/107865025/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Targeting_p21_activated_kinase_1_PAK1_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/107865025/0579abddebf80cf012ee7a7a00a448df5ebb-libre.pdf?1701019879=\u0026response-content-disposition=attachment%3B+filename%3DTargeting_p21_activated_kinase_1_PAK1_to.pdf\u0026Expires=1732409393\u0026Signature=XRNby9SmfHljamNPeFci--zgk9cdox8TxfkRIq3Y2vp~3OTDbiEZtuX7wuWPSin0em1-Rtv2O8Pc71qMtvB8u5yjOT~xw4jpVR35VE8LIw9JmZ8xN~qAqiSXvu4gmgsnLX2vtQg8~FZXdFuZDmQJsDkfsLQ9Qb3WfUAbok9wBTZNw1v8i7ZTiSrPRdfrv1dMb3I5dQ0mgyXrXdkuGIBVnOBkFfvp96gUeRxO7hmYxrZekEJ7qnnVhN2cW41xl9NYjYlcK4b6Liep6fwgF1nLXBkK9lI7l7IZJh5dS1c~pkC9P8Ku6ZZAGQ7IfZM2hzlKe2mji9CQ5MpRC7ZakmauuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":485892,"name":"CDC","url":"https://www.academia.edu/Documents/in/CDC"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":2068869,"name":"Academy of Sciences and Letters","url":"https://www.academia.edu/Documents/in/Academy_of_Sciences_and_Letters"},{"id":2079216,"name":"Lymph nodes","url":"https://www.academia.edu/Documents/in/Lymph_nodes"}],"urls":[{"id":35908661,"url":"https://pnas.org/doi/pdf/10.1073/pnas.1103350108"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104444436"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104444436/Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104444436/Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcriptio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104444436"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104444436"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104444436; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104444436]").text(description); $(".js-view-count[data-work-id=104444436]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104444436; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104444436']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104444436, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104444436]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104444436,"title":"Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"abstract":"Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","publisher":"American Association for Cancer Research (AACR)"},"translated_abstract":"Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","internal_url":"https://www.academia.edu/104444436/Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2023-07-10T16:33:51.727-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3240196" id="papers"><div class="js-work-strip profile--work_container" data-work-id="115797130"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797130/Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://attachments.academia-assets.com/112103601/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797130/Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, May 1, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4a15c4c6f67ad54d44b08e400bcab337" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103601,"asset_id":115797130,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103601/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797130"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797130"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797130; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797130]").text(description); $(".js-view-count[data-work-id=115797130]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797130; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797130']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797130, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4a15c4c6f67ad54d44b08e400bcab337" } } $('.js-work-strip[data-work-id=115797130]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797130,"title":"Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"publisher":"American Association for Cancer Research","publication_date":{"day":1,"month":5,"year":2008,"errors":{}},"publication_name":"Cancer Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797130/Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:36.923-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103601,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103601/thumbnails/1.jpg","file_name":"3124.pdf","download_url":"https://www.academia.edu/attachments/112103601/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Microphthalmia_Associated_Transcription.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103601/3124-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DMicrophthalmia_Associated_Transcription.pdf\u0026Expires=1732409392\u0026Signature=BONHywxpcgrQ3pQZS~zvtYUeZlUM4ZxaSZVtf6nsov3Uup9zluUHBMQNIJ4JRN7yIMx9ZKYuAsKFYU4CimPqjD~Y2D~L3hfRURdTKUq9mjs6PjyrCz102HIlaO8RHSve9NJJl3YjINJVRwRkp884Wnss-UXdtnCEa0UQwWFlpwdmP5qYIvJA3pCQ0JnFWwL3Yq0NTAIbhb3YTAWp47HMHxnJnAuqIh5SshZ7cMaXinaGG-O3dGRZLRvoCbc1OXtDMB8Onh9G44j~dPSQOD~fGMken0cShR42oo5oBXmAgZn4L5NJL45N8eTXIPAhjyhSEajmy5DLqH9Mm6UkECAq~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103601,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103601/thumbnails/1.jpg","file_name":"3124.pdf","download_url":"https://www.academia.edu/attachments/112103601/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Microphthalmia_Associated_Transcription.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103601/3124-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DMicrophthalmia_Associated_Transcription.pdf\u0026Expires=1732409392\u0026Signature=BONHywxpcgrQ3pQZS~zvtYUeZlUM4ZxaSZVtf6nsov3Uup9zluUHBMQNIJ4JRN7yIMx9ZKYuAsKFYU4CimPqjD~Y2D~L3hfRURdTKUq9mjs6PjyrCz102HIlaO8RHSve9NJJl3YjINJVRwRkp884Wnss-UXdtnCEa0UQwWFlpwdmP5qYIvJA3pCQ0JnFWwL3Yq0NTAIbhb3YTAWp47HMHxnJnAuqIh5SshZ7cMaXinaGG-O3dGRZLRvoCbc1OXtDMB8Onh9G44j~dPSQOD~fGMken0cShR42oo5oBXmAgZn4L5NJL45N8eTXIPAhjyhSEajmy5DLqH9Mm6UkECAq~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10937,"name":"Transcription Regulation","url":"https://www.academia.edu/Documents/in/Transcription_Regulation"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"}],"urls":[{"id":40039187,"url":"https://doi.org/10.1158/0008-5472.can-07-6622"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797129"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797129/Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs"><img alt="Research paper thumbnail of Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs" class="work-thumbnail" src="https://attachments.academia-assets.com/112103600/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797129/Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs">Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs</a></div><div class="wp-workCard_item"><span>ACS Chemical Biology</span><span>, Sep 1, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="db076ac51b200c6de59c84842aa472a7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103600,"asset_id":115797129,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103600/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797129"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797129"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797129; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797129]").text(description); $(".js-view-count[data-work-id=115797129]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797129; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797129']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797129, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "db076ac51b200c6de59c84842aa472a7" } } $('.js-work-strip[data-work-id=115797129]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797129,"title":"Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs","translated_title":"","metadata":{"publisher":"American Chemical Society","publication_date":{"day":1,"month":9,"year":2006,"errors":{}},"publication_name":"ACS Chemical Biology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797129/Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_internal_url":"","created_at":"2024-03-04T19:10:36.727-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103600/thumbnails/1.jpg","file_name":"j.bmcl.2005.04.00220240305-1-8t0bk7.pdf","download_url":"https://www.academia.edu/attachments/112103600/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Design_Synthesis_and_Biological_Activity.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103600/j.bmcl.2005.04.00220240305-1-8t0bk7-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DDesign_Synthesis_and_Biological_Activity.pdf\u0026Expires=1732409392\u0026Signature=Q0g34teMG~19DzSl8TYGKmR-JijRLsA-doBaA1E8MMo~9-b1gul6RDwj4FGMvPyGFncqPQSVZ6DGvL4u8-kTdq3ywqrWzEWIhcQORr4~ENbFV0LVs~jCwXfG5U~axloAFY8UdNEKwROWt8Su6Sjpm-EwgW6jA3Xmrt4GhCtfIjE6KgFWBXRfl0kcUxslYQSbzVMhrs7E33Du9R8Eq98AtPxH2a41tOUwCTfqOprGzetVminV5XOK3OfbaH7jWXxutQt4BTNSByDW8bzJ9ygwJDw4BT9WJaAqLbxduPM356q5QjHuQK6U9AzCAXt-WNglgJL4DV7RhjUKySKHJ3B4VQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103600,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103600/thumbnails/1.jpg","file_name":"j.bmcl.2005.04.00220240305-1-8t0bk7.pdf","download_url":"https://www.academia.edu/attachments/112103600/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Design_Synthesis_and_Biological_Activity.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103600/j.bmcl.2005.04.00220240305-1-8t0bk7-libre.pdf?1709614394=\u0026response-content-disposition=attachment%3B+filename%3DDesign_Synthesis_and_Biological_Activity.pdf\u0026Expires=1732409392\u0026Signature=Q0g34teMG~19DzSl8TYGKmR-JijRLsA-doBaA1E8MMo~9-b1gul6RDwj4FGMvPyGFncqPQSVZ6DGvL4u8-kTdq3ywqrWzEWIhcQORr4~ENbFV0LVs~jCwXfG5U~axloAFY8UdNEKwROWt8Su6Sjpm-EwgW6jA3Xmrt4GhCtfIjE6KgFWBXRfl0kcUxslYQSbzVMhrs7E33Du9R8Eq98AtPxH2a41tOUwCTfqOprGzetVminV5XOK3OfbaH7jWXxutQt4BTNSByDW8bzJ9ygwJDw4BT9WJaAqLbxduPM356q5QjHuQK6U9AzCAXt-WNglgJL4DV7RhjUKySKHJ3B4VQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":33441,"name":"Macromolecular X-Ray Crystallography","url":"https://www.academia.edu/Documents/in/Macromolecular_X-Ray_Crystallography"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":392067,"name":"Biomimetic materials","url":"https://www.academia.edu/Documents/in/Biomimetic_materials"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":1010725,"name":"Protein Binding","url":"https://www.academia.edu/Documents/in/Protein_Binding"},{"id":2486873,"name":"Inhibitor of apoptosis proteins","url":"https://www.academia.edu/Documents/in/Inhibitor_of_apoptosis_proteins"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":40039186,"url":"https://doi.org/10.1021/cb600276q"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797128"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797128/Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs"><img alt="Research paper thumbnail of Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797128/Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs">Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB, JNK and p38 MAPK signaling pathways is innermost activity of TNF receptor protein signaling complexes that is important for proper function of the immune system. However, excessive activation of these signaling pathways may result in tumor development and progression. Therefore, elucidation of the detailed molecular mechanisms of TNF receptor signaling should gain advantage in our understanding of the tumor biology and invention of the novel anticancer therapies. The formation of TNF receptor complexes, as well structural and functional associations between different signaling molecules is regulated by ubiquitination in TRAF-dependent fashion. TNF receptors employ several proteins possessing ubiquitin E3 ligase activities including cellular Inhibitor of Apoptosis, c-IAP1 and c-IAP2 proteins. We demonstrate that c-IAPs are required for canonical NF-kB and MAPK activation by TNF receptors. By regulating the recruitment of Nemo, IKK2 and HOIP to TNFR signaling complexes c-IAPs promote induction of gene expression by TNF ligands. We also found that TNF receptors that stimulate the noncanonical NF-kB pathway trigger c-IAPs, TRAF2 and TRAF3 intracellular translocation followed by their proteasomal and lysosomal degradation. Finally, we establish that BR3-induced cytosolic depletion of TRAF3 results in noncanonical NF-κB activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2151. doi:1538-7445.AM2012-2151</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797128"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797128"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797128; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797128]").text(description); $(".js-view-count[data-work-id=115797128]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797128; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797128']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797128, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797128]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797128,"title":"Abstract 2151: Activation of NF-kB and MAP kinases by TNF Family Receptors is regulated by cellular IAPs","translated_title":"","metadata":{"abstract":"Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB, JNK and p38 MAPK signaling pathways is innermost activity of TNF receptor protein signaling complexes that is important for proper function of the immune system. However, excessive activation of these signaling pathways may result in tumor development and progression. Therefore, elucidation of the detailed molecular mechanisms of TNF receptor signaling should gain advantage in our understanding of the tumor biology and invention of the novel anticancer therapies. The formation of TNF receptor complexes, as well structural and functional associations between different signaling molecules is regulated by ubiquitination in TRAF-dependent fashion. TNF receptors employ several proteins possessing ubiquitin E3 ligase activities including cellular Inhibitor of Apoptosis, c-IAP1 and c-IAP2 proteins. We demonstrate that c-IAPs are required for canonical NF-kB and MAPK activation by TNF receptors. By regulating the recruitment of Nemo, IKK2 and HOIP to TNFR signaling complexes c-IAPs promote induction of gene expression by TNF ligands. We also found that TNF receptors that stimulate the noncanonical NF-kB pathway trigger c-IAPs, TRAF2 and TRAF3 intracellular translocation followed by their proteasomal and lysosomal degradation. Finally, we establish that BR3-induced cytosolic depletion of TRAF3 results in noncanonical NF-κB activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2151. doi:1538-7445.AM2012-2151","publication_date":{"day":15,"month":4,"year":2012,"errors":{}}},"translated_abstract":"Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Activation of NF-kB, JNK and p38 MAPK signaling pathways is innermost activity of TNF receptor protein signaling complexes that is important for proper function of the immune system. However, excessive activation of these signaling pathways may result in tumor development and progression. Therefore, elucidation of the detailed molecular mechanisms of TNF receptor signaling should gain advantage in our understanding of the tumor biology and invention of the novel anticancer therapies. The formation of TNF receptor complexes, as well structural and functional associations between different signaling molecules is regulated by ubiquitination in TRAF-dependent fashion. TNF receptors employ several proteins possessing ubiquitin E3 ligase activities including cellular Inhibitor of Apoptosis, c-IAP1 and c-IAP2 proteins. We demonstrate that c-IAPs are required for canonical NF-kB and MAPK activation by TNF receptors. By regulating the recruitment of Nemo, IKK2 and HOIP to TNFR signaling complexes c-IAPs promote induction of gene expression by TNF ligands. We also found that TNF receptors that stimulate the noncanonical NF-kB pathway trigger c-IAPs, TRAF2 and TRAF3 intracellular translocation followed by their proteasomal and lysosomal degradation. Finally, we establish that BR3-induced cytosolic depletion of TRAF3 results in noncanonical NF-κB activation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2151. doi:1538-7445.AM2012-2151","internal_url":"https://www.academia.edu/115797128/Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs","translated_internal_url":"","created_at":"2024-03-04T19:10:36.505-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Abstract_2151_Activation_of_NF_kB_and_MAP_kinases_by_TNF_Family_Receptors_is_regulated_by_cellular_IAPs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor"}],"urls":[{"id":40039185,"url":"https://doi.org/10.1158/1538-7445.am2012-2151"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797127"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797127/The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer"><img alt="Research paper thumbnail of The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/112103581/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797127/The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer">The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer</a></div><div class="wp-workCard_item"><span>Clinical Cancer Research</span><span>, Oct 15, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7a206cfdf5f2f01f61c32ac3376544e8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103581,"asset_id":115797127,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103581/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797127"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797127"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797127; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797127]").text(description); $(".js-view-count[data-work-id=115797127]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797127; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797127']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797127, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7a206cfdf5f2f01f61c32ac3376544e8" } } $('.js-work-strip[data-work-id=115797127]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797127,"title":"The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer","translated_title":"","metadata":{"publisher":"American Association for Cancer Research","publication_date":{"day":15,"month":10,"year":2007,"errors":{}},"publication_name":"Clinical Cancer Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797127/The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer","translated_internal_url":"","created_at":"2024-03-04T19:10:36.315-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103581,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103581/thumbnails/1.jpg","file_name":"5995.pdf","download_url":"https://www.academia.edu/attachments/112103581/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Inhibitor_of_Apoptosis_Proteins_as_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103581/5995-libre.pdf?1709614402=\u0026response-content-disposition=attachment%3B+filename%3DThe_Inhibitor_of_Apoptosis_Proteins_as_T.pdf\u0026Expires=1732409392\u0026Signature=RWFCc0O0SiwF3X3LdbAskY7g5GT1kpVYCxKsMnvVdJFmEUFq8PEgHQzq32dNQyUjLK3kmVuPka6L57hXo5Z4ID22SjgKQJXB2Kcq9Z-BvP~okG~93kzc3bMl6zTeYAii~iqYHkoPFLxcvpeV5Q~-b~0~prxDZ3M3yxd3hBX12goaAQmevwpNILmNfICsaF-B0EE7w3ynVO6U8PIq983Qu6ywDCtO3LrwgWom998V95ePLEaHNF73iDvuhoXMu909w6Y04zl0cYj2GvZqJMnVqHwY1kQyBKwkp~8Db66P34GwFqfDO4JDElNyC2mrJm-ftYjdCgcQhF4x8mL0S19JYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Inhibitor_of_Apoptosis_Proteins_as_Therapeutic_Targets_in_Cancer","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103581,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103581/thumbnails/1.jpg","file_name":"5995.pdf","download_url":"https://www.academia.edu/attachments/112103581/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Inhibitor_of_Apoptosis_Proteins_as_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103581/5995-libre.pdf?1709614402=\u0026response-content-disposition=attachment%3B+filename%3DThe_Inhibitor_of_Apoptosis_Proteins_as_T.pdf\u0026Expires=1732409392\u0026Signature=RWFCc0O0SiwF3X3LdbAskY7g5GT1kpVYCxKsMnvVdJFmEUFq8PEgHQzq32dNQyUjLK3kmVuPka6L57hXo5Z4ID22SjgKQJXB2Kcq9Z-BvP~okG~93kzc3bMl6zTeYAii~iqYHkoPFLxcvpeV5Q~-b~0~prxDZ3M3yxd3hBX12goaAQmevwpNILmNfICsaF-B0EE7w3ynVO6U8PIq983Qu6ywDCtO3LrwgWom998V95ePLEaHNF73iDvuhoXMu909w6Y04zl0cYj2GvZqJMnVqHwY1kQyBKwkp~8Db66P34GwFqfDO4JDElNyC2mrJm-ftYjdCgcQhF4x8mL0S19JYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103582,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103582/thumbnails/1.jpg","file_name":"5995.pdf","download_url":"https://www.academia.edu/attachments/112103582/download_file","bulk_download_file_name":"The_Inhibitor_of_Apoptosis_Proteins_as_T.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103582/5995-libre.pdf?1709614403=\u0026response-content-disposition=attachment%3B+filename%3DThe_Inhibitor_of_Apoptosis_Proteins_as_T.pdf\u0026Expires=1732409392\u0026Signature=XhKKO8velBF4NzdK~63jHqcWdBt1KE3n51c43QH5J-fWkhCx45Gwo6wylPZCVeYo8hN0bSYwqqeKkkf~S7jhUF3sXpoIzCm9SoPtoDSulL36LhPAlIqrMCQu0yvjnIIoZaDD10CoFP5~IbvbAZk2ENfIi8P1I9PTvhQN11eAoTpI8xE-~vlplpZrQpb-QtrQvzlq~msIYWnCxZKEX5cNco1YgHpAzqKmsIFjSlFerk-iEk-btOeMNK6GX1faOTtxpsDM2bsTZ4ILgli9G5b1CBDf~qu71SccQNwSFJVlMY33kJfUTKLhGdnTBAZ~~XkoXnkaD6P0IYkJXlA8mV2nmw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"}],"urls":[{"id":40039184,"url":"https://aacrjournals.org/clincancerres/article-pdf/13/20/5995/1972371/5995.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797126/Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Figure 1 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://attachments.academia-assets.com/112103585/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797126/Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Figure 1 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9b26652c72ee33e48ff7db84c2961e98" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103585,"asset_id":115797126,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103585/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797126; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797126]").text(description); $(".js-view-count[data-work-id=115797126]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797126; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797126']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797126, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9b26652c72ee33e48ff7db84c2961e98" } } $('.js-work-strip[data-work-id=115797126]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797126,"title":"Supplementary Figure 1 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797126/Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:36.039-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103585,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103585/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_1.pdf","download_url":"https://www.academia.edu/attachments/112103585/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_1_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103585/00085472can076622-sup-sfig_1-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=eG7mMtzHmywljMXr88nnbo6JSks-Nk5IR~VkHAZ33ftV~PasUPN5Q6xiQ-NrWsMiIz9U6-eZcnRb3uJhQWEZ5hdb8xU-fS-8TsjwWiFMUESMSJwalNf2~sVYwxA0v~ct3hbAzh9h2355LfgFR-j1nWREMkKUN~mlzCw-lVQeTxmYz5h4S~VkVeOT0ij~4SIbJRV8FnJeymOekgPkqZAWHonkEbwbDsTQO2inOEG6FI5YC-fJG7jdT1U8l3yPfvOvvwMV72AxjE0aZ~yj8shD9fTbAC~WLvsMeuU9qc4FzU0NX6wwteeE3UA-m4pVgD3D163bRg-4sC5vDGcgIfuLew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Supplementary_Figure_1_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103585,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103585/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_1.pdf","download_url":"https://www.academia.edu/attachments/112103585/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_1_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103585/00085472can076622-sup-sfig_1-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=eG7mMtzHmywljMXr88nnbo6JSks-Nk5IR~VkHAZ33ftV~PasUPN5Q6xiQ-NrWsMiIz9U6-eZcnRb3uJhQWEZ5hdb8xU-fS-8TsjwWiFMUESMSJwalNf2~sVYwxA0v~ct3hbAzh9h2355LfgFR-j1nWREMkKUN~mlzCw-lVQeTxmYz5h4S~VkVeOT0ij~4SIbJRV8FnJeymOekgPkqZAWHonkEbwbDsTQO2inOEG6FI5YC-fJG7jdT1U8l3yPfvOvvwMV72AxjE0aZ~yj8shD9fTbAC~WLvsMeuU9qc4FzU0NX6wwteeE3UA-m4pVgD3D163bRg-4sC5vDGcgIfuLew__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"},{"id":3830245,"name":"Microphthalmia","url":"https://www.academia.edu/Documents/in/Microphthalmia"}],"urls":[{"id":40039183,"url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Microphthalmia-Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas/22375457/1/files/39820739.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797125/Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797125/Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797125]").text(description); $(".js-view-count[data-work-id=115797125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797125,"title":"Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"abstract":"Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":"Supplementary Figure 3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","internal_url":"https://www.academia.edu/115797125/Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:35.822-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Supplementary_Figure_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"},{"id":3830245,"name":"Microphthalmia","url":"https://www.academia.edu/Documents/in/Microphthalmia"}],"urls":[{"id":40039182,"url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Microphthalmia-Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas/22375451/1/files/39820733.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797124"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797124/Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Figure 2 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://attachments.academia-assets.com/112103584/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797124/Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Figure 2 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9896ffacd96aacc7832a0a244d0fc90d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103584,"asset_id":115797124,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103584/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797124"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797124"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797124; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797124]").text(description); $(".js-view-count[data-work-id=115797124]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797124; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797124']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797124, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9896ffacd96aacc7832a0a244d0fc90d" } } $('.js-work-strip[data-work-id=115797124]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797124,"title":"Supplementary Figure 2 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797124/Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:35.590-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103584,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103584/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_2.pdf","download_url":"https://www.academia.edu/attachments/112103584/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_2_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103584/00085472can076622-sup-sfig_2-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=F9Q-70HQsfMUiws~ID3Szt8KGgxuvfgAzeNWCEWSf8JuVVKT0CJg-3uO12z46JihIJHa3pXw5awLG3F4VKbX0Tb-DGrFu9g0DvTTVAfwK1G7KQYBmxuyz7CzQLD6wt2YCANExpejVOLqLtTX7NAqmb6hqXsaIrmQSOr9dSLBRQlY0zXbnSoGsAqDEle2U5Dj7TgUfERJk~NhEBZRblZxMI9Ow6jlAsECIHizhkkwDghg77H1696H5wTmjXK0EvqFKMNgNKEy2A74GI9-Vq~vkX-awXWu1XBOdL-kiX9StUUZIDi4IAP99SfF3W8CmJDGJQEse8ptD2VpFCgTtEHnhQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Supplementary_Figure_2_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103584,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103584/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_2.pdf","download_url":"https://www.academia.edu/attachments/112103584/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Supplementary_Figure_2_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103584/00085472can076622-sup-sfig_2-libre.pdf?1709614395=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=F9Q-70HQsfMUiws~ID3Szt8KGgxuvfgAzeNWCEWSf8JuVVKT0CJg-3uO12z46JihIJHa3pXw5awLG3F4VKbX0Tb-DGrFu9g0DvTTVAfwK1G7KQYBmxuyz7CzQLD6wt2YCANExpejVOLqLtTX7NAqmb6hqXsaIrmQSOr9dSLBRQlY0zXbnSoGsAqDEle2U5Dj7TgUfERJk~NhEBZRblZxMI9Ow6jlAsECIHizhkkwDghg77H1696H5wTmjXK0EvqFKMNgNKEy2A74GI9-Vq~vkX-awXWu1XBOdL-kiX9StUUZIDi4IAP99SfF3W8CmJDGJQEse8ptD2VpFCgTtEHnhQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103583,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103583/thumbnails/1.jpg","file_name":"00085472can076622-sup-sfig_2.pdf","download_url":"https://www.academia.edu/attachments/112103583/download_file","bulk_download_file_name":"Supplementary_Figure_2_from_Microphthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103583/00085472can076622-sup-sfig_2-libre.pdf?1709614398=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Microphthalm.pdf\u0026Expires=1732409392\u0026Signature=VBhbLYIumVCao9r6yL6cdGxLH3v930S02xqZO21qv6Keai1MLzR90cDPATL8TbUpFJRt2ywlfM2mL2k0MDVffnudBLrgc0D6KB~3nqo-lifS1MF6GL-yYDpKtvYolCvfsxWndimsMvTkZk39pC5ZOCYsyKsGMSA00LwBhN-HbXkcLlNdToY-Kz44K3N6RCFFN4sanWHSKdDctLcuKz8EGbqfpXHbg5Bi7VtJ17in1JXGZ2nI-GBL5rU-MMHIms-XeUcn5owUnm8sVs3NAGpr28nhHOuNv3TMWCwe7j7JWr~fVHTaa~TInnZKbdytKZMFnOodj8zi9weMt8Jx7boWHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"},{"id":3830245,"name":"Microphthalmia","url":"https://www.academia.edu/Documents/in/Microphthalmia"}],"urls":[{"id":40039181,"url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_Microphthalmia-Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas/22375454/1/files/39820736.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797123"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797123/Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Data from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797123/Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Data from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells. The ML-IAP promoter contains two MITF consensus sites, and analysis of MITF and ML-IAP mRNA levels revealed a high correlation in melanoma tumor samples and cell lines. In reporter assays, MITF promoted a strong stimulation of transcriptional activity from the ML-IAP promoter, and MITF bound the endogenous ML-IAP promoter in melanoma cells by chromatin immunoprecipitation and electrophoretic mobility shift assay. Strikingly, small interfering RNA (siRNA)–mediated knockdown of MITF in melanoma cells led to a dramatic decrease in ML-IAP mRNA and protein levels, establishing that ML-IAP expression in melanoma cells is MITF dependent. Additionally, cyclic AMP–mediated induction of MITF expression in melanocytes resulted in increased ML-IAP expression, suggesting that melanocytes can express ML-IAP when MITF levels are heightened. Disruption of MITF by siRNA led to a decrease in melanoma cell viability, which could be rescued by ectopic expression of ML-IAP. Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. [Cancer Res 2008;68(9):3124–32]</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797123"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797123"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797123; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797123]").text(description); $(".js-view-count[data-work-id=115797123]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797123; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797123']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797123, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797123]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797123,"title":"Data from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"abstract":"Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells. The ML-IAP promoter contains two MITF consensus sites, and analysis of MITF and ML-IAP mRNA levels revealed a high correlation in melanoma tumor samples and cell lines. In reporter assays, MITF promoted a strong stimulation of transcriptional activity from the ML-IAP promoter, and MITF bound the endogenous ML-IAP promoter in melanoma cells by chromatin immunoprecipitation and electrophoretic mobility shift assay. Strikingly, small interfering RNA (siRNA)–mediated knockdown of MITF in melanoma cells led to a dramatic decrease in ML-IAP mRNA and protein levels, establishing that ML-IAP expression in melanoma cells is MITF dependent. Additionally, cyclic AMP–mediated induction of MITF expression in melanocytes resulted in increased ML-IAP expression, suggesting that melanocytes can express ML-IAP when MITF levels are heightened. Disruption of MITF by siRNA led to a decrease in melanoma cell viability, which could be rescued by ectopic expression of ML-IAP. Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. [Cancer Res 2008;68(9):3124–32]","publication_date":{"day":30,"month":3,"year":2023,"errors":{}}},"translated_abstract":"Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells. The ML-IAP promoter contains two MITF consensus sites, and analysis of MITF and ML-IAP mRNA levels revealed a high correlation in melanoma tumor samples and cell lines. In reporter assays, MITF promoted a strong stimulation of transcriptional activity from the ML-IAP promoter, and MITF bound the endogenous ML-IAP promoter in melanoma cells by chromatin immunoprecipitation and electrophoretic mobility shift assay. Strikingly, small interfering RNA (siRNA)–mediated knockdown of MITF in melanoma cells led to a dramatic decrease in ML-IAP mRNA and protein levels, establishing that ML-IAP expression in melanoma cells is MITF dependent. Additionally, cyclic AMP–mediated induction of MITF expression in melanocytes resulted in increased ML-IAP expression, suggesting that melanocytes can express ML-IAP when MITF levels are heightened. Disruption of MITF by siRNA led to a decrease in melanoma cell viability, which could be rescued by ectopic expression of ML-IAP. Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. [Cancer Res 2008;68(9):3124–32]","internal_url":"https://www.academia.edu/115797123/Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2024-03-04T19:10:35.374-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Data_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":440820,"name":"Chromatin Immunoprecipitation","url":"https://www.academia.edu/Documents/in/Chromatin_Immunoprecipitation"}],"urls":[{"id":40039180,"url":"https://doi.org/10.1158/0008-5472.c.6497828"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797122"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797122/Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs"><img alt="Research paper thumbnail of Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797122/Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs">Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs</a></div><div class="wp-workCard_item"><span>ACS Chemical Biology</span><span>, Oct 1, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797122"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797122"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797122; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797122]").text(description); $(".js-view-count[data-work-id=115797122]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797122; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797122']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797122, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797122]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797122,"title":"Correction: Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs","translated_title":"","metadata":{"abstract":"Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML ...","publisher":"American Chemical Society","publication_date":{"day":1,"month":10,"year":2006,"errors":{}},"publication_name":"ACS Chemical Biology"},"translated_abstract":"Designed second mitochondrial activator of caspases (Smac) mimetics based on an accessible [7, 5]-bicyclic scaffold bind to and antagonize protein interactions involving the inhibitor of apoptosis (IAP) proteins, X-chromosome-linked IAP (XIAP), melanoma IAP (ML ...","internal_url":"https://www.academia.edu/115797122/Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_internal_url":"","created_at":"2024-03-04T19:10:35.112-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Correction_Design_Synthesis_and_Biological_Activity_of_a_Potent_Smac_Mimetic_That_Sensitizes_Cancer_Cells_to_Apoptosis_by_Antagonizing_IAPs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":12981,"name":"Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Enzyme_Inhibitors"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":120789,"name":"Drug Design","url":"https://www.academia.edu/Documents/in/Drug_Design"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":199319,"name":"Citation","url":"https://www.academia.edu/Documents/in/Citation"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":392067,"name":"Biomimetic materials","url":"https://www.academia.edu/Documents/in/Biomimetic_materials"},{"id":463081,"name":"Acetylation","url":"https://www.academia.edu/Documents/in/Acetylation"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":901298,"name":"Glucose Tolerance Test","url":"https://www.academia.edu/Documents/in/Glucose_Tolerance_Test"},{"id":2486873,"name":"Inhibitor of apoptosis proteins","url":"https://www.academia.edu/Documents/in/Inhibitor_of_apoptosis_proteins"},{"id":2898895,"name":"binding sites","url":"https://www.academia.edu/Documents/in/binding_sites"},{"id":3004151,"name":"CHO cells","url":"https://www.academia.edu/Documents/in/CHO_cells"},{"id":3214915,"name":"Cricetinae","url":"https://www.academia.edu/Documents/in/Cricetinae"}],"urls":[{"id":40039179,"url":"https://doi.org/10.1021/cb6004195"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797121"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797121/Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling"><img alt="Research paper thumbnail of Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling" class="work-thumbnail" src="https://attachments.academia-assets.com/112103599/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797121/Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling">Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling</a></div><div class="wp-workCard_item"><span>Molecular Cell</span><span>, Feb 1, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef2fdccf2bf104b332ba5f947b79d34c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103599,"asset_id":115797121,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103599/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797121"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797121"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797121; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797121]").text(description); $(".js-view-count[data-work-id=115797121]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797121; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797121']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797121, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef2fdccf2bf104b332ba5f947b79d34c" } } $('.js-work-strip[data-work-id=115797121]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797121,"title":"Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":1,"month":2,"year":2018,"errors":{}},"publication_name":"Molecular Cell"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797121/Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling","translated_internal_url":"","created_at":"2024-03-04T19:10:34.923-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103599/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/112103599/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Disruption_of_XIAP_RIP2_Association_Bloc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103599/pdf-libre.pdf?1709614994=\u0026response-content-disposition=attachment%3B+filename%3DDisruption_of_XIAP_RIP2_Association_Bloc.pdf\u0026Expires=1732409392\u0026Signature=YT1NJ3~PsggvFuyIFc1Db1NKG18ugIM8jp-bEracITO1gncMwjq~QpyEICpCarN5MMI4QIedvcXBast8rC5GUTfaNwcfeVCbjgnm5kZcGZtVPhbA~xxSXaB7AVRicGui7gmI5x0Iz~E8qkNAgNsxEG-NgQb2TEGv1E9glqS1Otkvkj-0g8j3KanowerpvmE1gVWeTV~xfRMQ~Vr9DyRRAfys3jYSZu6vRWYbcFloi22rMSveT75XVgb3jI0LIisNKXwitfq6Tp-DoXPDE4pEhqWQ7EiQEhXcRIeQyyjI1m11IE~-z5SwJGY5OhpqKt9~J7bFXVcQ~GPHsi6VzYEyAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Disruption_of_XIAP_RIP2_Association_Blocks_NOD2_Mediated_Inflammatory_Signaling","translated_slug":"","page_count":23,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103599,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103599/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/112103599/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Disruption_of_XIAP_RIP2_Association_Bloc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103599/pdf-libre.pdf?1709614994=\u0026response-content-disposition=attachment%3B+filename%3DDisruption_of_XIAP_RIP2_Association_Bloc.pdf\u0026Expires=1732409392\u0026Signature=YT1NJ3~PsggvFuyIFc1Db1NKG18ugIM8jp-bEracITO1gncMwjq~QpyEICpCarN5MMI4QIedvcXBast8rC5GUTfaNwcfeVCbjgnm5kZcGZtVPhbA~xxSXaB7AVRicGui7gmI5x0Iz~E8qkNAgNsxEG-NgQb2TEGv1E9glqS1Otkvkj-0g8j3KanowerpvmE1gVWeTV~xfRMQ~Vr9DyRRAfys3jYSZu6vRWYbcFloi22rMSveT75XVgb3jI0LIisNKXwitfq6Tp-DoXPDE4pEhqWQ7EiQEhXcRIeQyyjI1m11IE~-z5SwJGY5OhpqKt9~J7bFXVcQ~GPHsi6VzYEyAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":46578,"name":"Cell and Molecular Biology","url":"https://www.academia.edu/Documents/in/Cell_and_Molecular_Biology"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"},{"id":3135141,"name":"nod","url":"https://www.academia.edu/Documents/in/nod"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":40039178,"url":"https://doi.org/10.1016/j.molcel.2018.01.016"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797120"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797120/Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold"><img alt="Research paper thumbnail of Antagonists of IAP proteins based on an azabicyclooctane scaffold" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797120/Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold">Antagonists of IAP proteins based on an azabicyclooctane scaffold</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, May 1, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was used to design potential proline mimetics. The synthesis of an azabicyclooctane core, and incorporation of this core into elaborated antagonists is described. The binding of these compounds to IAP proteins was assessed by fluorescence polarization competition assay, and several compounds with Kis of</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797120"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797120]").text(description); $(".js-view-count[data-work-id=115797120]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797120']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797120, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797120]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797120,"title":"Antagonists of IAP proteins based on an azabicyclooctane scaffold","translated_title":"","metadata":{"abstract":"4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was used to design potential proline mimetics. The synthesis of an azabicyclooctane core, and incorporation of this core into elaborated antagonists is described. The binding of these compounds to IAP proteins was assessed by fluorescence polarization competition assay, and several compounds with Kis of","publisher":"American Association for Cancer Research","publication_date":{"day":1,"month":5,"year":2007,"errors":{}},"publication_name":"Cancer Research"},"translated_abstract":"4736 Starting from a co-crystal structure of the peptide AVPW with ML-IAP, the program CAVEAT was used to design potential proline mimetics. The synthesis of an azabicyclooctane core, and incorporation of this core into elaborated antagonists is described. The binding of these compounds to IAP proteins was assessed by fluorescence polarization competition assay, and several compounds with Kis of","internal_url":"https://www.academia.edu/115797120/Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold","translated_internal_url":"","created_at":"2024-03-04T19:10:34.732-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antagonists_of_IAP_proteins_based_on_an_azabicyclooctane_scaffold","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"}],"urls":[{"id":40039177,"url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/4736"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797119"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797119/Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023"><img alt="Research paper thumbnail of Apoptotic cell death in disease—Current understanding of the NCCD 2023" class="work-thumbnail" src="https://attachments.academia-assets.com/112103580/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797119/Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023">Apoptotic cell death in disease—Current understanding of the NCCD 2023</a></div><div class="wp-workCard_item"><span>Cell Death &amp; Differentiation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c50ba54e0c490d80350d2d2f63ce3a7c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103580,"asset_id":115797119,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103580/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797119"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797119"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797119; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797119]").text(description); $(".js-view-count[data-work-id=115797119]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797119; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797119']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797119, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c50ba54e0c490d80350d2d2f63ce3a7c" } } $('.js-work-strip[data-work-id=115797119]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797119,"title":"Apoptotic cell death in disease—Current understanding of the NCCD 2023","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_name":"Cell Death \u0026amp; Differentiation"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797119/Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023","translated_internal_url":"","created_at":"2024-03-04T19:10:34.483-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103580,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103580/thumbnails/1.jpg","file_name":"s41418-023-01153-w.pdf","download_url":"https://www.academia.edu/attachments/112103580/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Apoptotic_cell_death_in_disease_Current.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103580/s41418-023-01153-w-libre.pdf?1709614448=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_cell_death_in_disease_Current.pdf\u0026Expires=1732409392\u0026Signature=FSTfqaTuMlEQ32~DxbobIa6vUHliz0SeEXYZjJ02~5QH52T3I~zknFknR0l0L~xSsTr5D75VM3y03303c83wveYf~y5WVQm7LYJHJo66u8ItdAby3yW1BpBgBrygyJV7f0kjQpv3CHRldjFwEIjYmQneXp43DzeubXVt4E3l~NIvNiLnZawQYtpm2tCzrodC6bEFtIjwy8F6WJyZcC0ZbYUaPceM45NBoZfT8kUoWH-9HlCOgfVepxwvqyvT-dnBkL9bxGXird8r-~PrQIJTKGYVo71t3gdjVod27zf3CDwyfsbyVC7V5wU7YaLtE3z~gGhikOnJBPY4MEvJ8Ys8Uw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Apoptotic_cell_death_in_disease_Current_understanding_of_the_NCCD_2023","translated_slug":"","page_count":58,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103580,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103580/thumbnails/1.jpg","file_name":"s41418-023-01153-w.pdf","download_url":"https://www.academia.edu/attachments/112103580/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Apoptotic_cell_death_in_disease_Current.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103580/s41418-023-01153-w-libre.pdf?1709614448=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_cell_death_in_disease_Current.pdf\u0026Expires=1732409392\u0026Signature=FSTfqaTuMlEQ32~DxbobIa6vUHliz0SeEXYZjJ02~5QH52T3I~zknFknR0l0L~xSsTr5D75VM3y03303c83wveYf~y5WVQm7LYJHJo66u8ItdAby3yW1BpBgBrygyJV7f0kjQpv3CHRldjFwEIjYmQneXp43DzeubXVt4E3l~NIvNiLnZawQYtpm2tCzrodC6bEFtIjwy8F6WJyZcC0ZbYUaPceM45NBoZfT8kUoWH-9HlCOgfVepxwvqyvT-dnBkL9bxGXird8r-~PrQIJTKGYVo71t3gdjVod27zf3CDwyfsbyVC7V5wU7YaLtE3z~gGhikOnJBPY4MEvJ8Ys8Uw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103579,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103579/thumbnails/1.jpg","file_name":"s41418-023-01153-w.pdf","download_url":"https://www.academia.edu/attachments/112103579/download_file","bulk_download_file_name":"Apoptotic_cell_death_in_disease_Current.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103579/s41418-023-01153-w-libre.pdf?1709614452=\u0026response-content-disposition=attachment%3B+filename%3DApoptotic_cell_death_in_disease_Current.pdf\u0026Expires=1732409392\u0026Signature=WW22vizWllKP4f~Qrcj0VlnTKemdC4zx6n~7r0pY46RoAp49SwKKbCG5VQpbVE0Sz8DI9kr3dB0BahuDLBzCvVD3wtfN7K7FD~EAbmivKXtmYDDAvLW40wP-AvgiEhYcs4ady7e3~6mQmXD0eekrYLf4UeCuPXqdYcSwoqbp0XSWHoh6dvRIjRRzthOIc8APZDVWykjNorPFdt-gDGQpTGBbYmPChYBWrQTO-j7SpviMciAgx9q8LcZaOB4rlWRoa2wZZsODgc1u6cOQTtQvAiDi2m1X05CBLPF3izH6UKAEyqIqeOBti096eb3kTbqUnxYdoB33Zl6F3nF7nQMzvg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis"},{"id":857512,"name":"Proteases","url":"https://www.academia.edu/Documents/in/Proteases"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":40039176,"url":"https://www.nature.com/articles/s41418-023-01153-w.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797118"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797118/RIP1_post_translational_modifications"><img alt="Research paper thumbnail of RIP1 post-translational modifications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797118/RIP1_post_translational_modifications">RIP1 post-translational modifications</a></div><div class="wp-workCard_item"><span>Biochemical Journal</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell dea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797118"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797118"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797118; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797118]").text(description); $(".js-view-count[data-work-id=115797118]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797118; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797118']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797118, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797118]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797118,"title":"RIP1 post-translational modifications","translated_title":"","metadata":{"abstract":"Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, an...","publisher":"Portland Press Ltd.","publication_name":"Biochemical Journal"},"translated_abstract":"Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage by caspase-8, RIP1 autophosphorylation, and phosphorylation by a number of signaling kinases can greatly impact cellular fate. Disruption of the tightly regulated RIP1 modifications can lead to signaling disbalance in TNF and/or TLR controlled and other inflammatory pathways, and result in severe human pathologies. This review will focus on RIP1 and its many modifications with an emphasis on ubiquitination, phosphorylation, an...","internal_url":"https://www.academia.edu/115797118/RIP1_post_translational_modifications","translated_internal_url":"","created_at":"2024-03-04T19:10:34.261-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"RIP1_post_translational_modifications","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":55266,"name":"Ubiquitin","url":"https://www.academia.edu/Documents/in/Ubiquitin"},{"id":172083,"name":"Phosphorylation","url":"https://www.academia.edu/Documents/in/Phosphorylation"},{"id":176525,"name":"Biochemical","url":"https://www.academia.edu/Documents/in/Biochemical"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES"},{"id":1947599,"name":"Autophosphorylation","url":"https://www.academia.edu/Documents/in/Autophosphorylation"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":40039175,"url":"https://portlandpress.com/biochemj/article-pdf/479/9/929/932569/bcj-2021-0725c.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797117"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797117/Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd"><img alt="Research paper thumbnail of Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797117/Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd">Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd</a></div><div class="wp-workCard_item"><span>Transplantation and Cellular Therapy</span><span>, Feb 1, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797117"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797117"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797117; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797117]").text(description); $(".js-view-count[data-work-id=115797117]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797117; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797117']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797117, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797117]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797117,"title":"Inhibition of the Receptor Interactive Protein Kinase 1 (RIP1) Pathway Prevents Acute Gvhd","translated_title":"","metadata":{"publication_date":{"day":1,"month":2,"year":2023,"errors":{}},"publication_name":"Transplantation and Cellular Therapy"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797117/Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd","translated_internal_url":"","created_at":"2024-03-04T19:10:34.053-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Inhibition_of_the_Receptor_Interactive_Protein_Kinase_1_RIP1_Pathway_Prevents_Acute_Gvhd","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[],"urls":[{"id":40039174,"url":"https://doi.org/10.1016/s2666-6367(23)00074-x"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797116"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797116/IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition"><img alt="Research paper thumbnail of IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition" class="work-thumbnail" src="https://attachments.academia-assets.com/112103577/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797116/IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition">IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition</a></div><div class="wp-workCard_item"><span>Cell Death &amp; Disease</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f172b0081ef860864b4f5c6595a1d74a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103577,"asset_id":115797116,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103577/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797116"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797116]").text(description); $(".js-view-count[data-work-id=115797116]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797116']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797116, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f172b0081ef860864b4f5c6595a1d74a" } } $('.js-work-strip[data-work-id=115797116]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797116,"title":"IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_name":"Cell Death \u0026amp; Disease"},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797116/IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition","translated_internal_url":"","created_at":"2024-03-04T19:10:33.854-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103577,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103577/thumbnails/1.jpg","file_name":"s41419-022-05283-w.pdf","download_url":"https://www.academia.edu/attachments/112103577/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_GDC_0917_is_more_potent_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103577/s41419-022-05283-w-libre.pdf?1709614396=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_GDC_0917_is_more_potent_t.pdf\u0026Expires=1732409392\u0026Signature=eJyBWocWBt~C9k05qL8JDkYYcwmoMVfptl3JQRVkP39fbENPOwN5ZtJbqU580emtR4eyW8xccUKGyQtG8WuKYdOsAPYptfPrgVkw0UNSzem0XuN4GhWpQvTm5olmaDRjBBYD2ewWO~6PViEDa2YvCy92uBaJXyaHlamN8c2r9FnC4Q7ahTzDHKtYxAbNJdgpkpknssQML1fHOhh2kpN6fHiAXWq7~Cqbu~2lDP7gpXfR7d5Y-Akkm-WA5ZjBVKRyWBk9vbLTYZjA6MBcOUCV1geOGkEndPXb1WO0q~fTTnPcuPNvP~YKesyaQ9BO8RrgFujOVc6lNqxmNkHV7Hh~vw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"IAP_antagonist_GDC_0917_is_more_potent_than_Debio1143_in_promoting_cell_death_c_IAP1_degradation_and_tumor_growth_inhibition","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103577,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103577/thumbnails/1.jpg","file_name":"s41419-022-05283-w.pdf","download_url":"https://www.academia.edu/attachments/112103577/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Miw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_GDC_0917_is_more_potent_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103577/s41419-022-05283-w-libre.pdf?1709614396=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_GDC_0917_is_more_potent_t.pdf\u0026Expires=1732409392\u0026Signature=eJyBWocWBt~C9k05qL8JDkYYcwmoMVfptl3JQRVkP39fbENPOwN5ZtJbqU580emtR4eyW8xccUKGyQtG8WuKYdOsAPYptfPrgVkw0UNSzem0XuN4GhWpQvTm5olmaDRjBBYD2ewWO~6PViEDa2YvCy92uBaJXyaHlamN8c2r9FnC4Q7ahTzDHKtYxAbNJdgpkpknssQML1fHOhh2kpN6fHiAXWq7~Cqbu~2lDP7gpXfR7d5Y-Akkm-WA5ZjBVKRyWBk9vbLTYZjA6MBcOUCV1geOGkEndPXb1WO0q~fTTnPcuPNvP~YKesyaQ9BO8RrgFujOVc6lNqxmNkHV7Hh~vw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112103578,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103578/thumbnails/1.jpg","file_name":"s41419-022-05283-w.pdf","download_url":"https://www.academia.edu/attachments/112103578/download_file","bulk_download_file_name":"IAP_antagonist_GDC_0917_is_more_potent_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103578/s41419-022-05283-w-libre.pdf?1709614396=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_GDC_0917_is_more_potent_t.pdf\u0026Expires=1732409392\u0026Signature=aqCttp0gk1NHIIA~mG-4wipm8hK7uJ5zncyRt15kMtd7bt1SS9dMbRPSemJGqVWFIDlmRghxiRi2eNglm2NaLziA2sHqp17RiiUvQ7BvoFEo0HA2YQb8U~GF58UhyDmbu6G4KcO5BsSvn5veZkuNsL~~jl0PEaNXgYWaG-52sF42vjr~edvUATVy6vMslI~qFg8Zdcabt4bTXW-~lqcsH3uRVAJ6scHiEbmkfWlBwL3rduj4EJPXasjNnHQUmMrX0aTgeDHYz4iOs1lZCSLCY3bEBzKfS7rKbbeOibklsBIaATfuxRpb~Tj7tDZu9MGvhPTUk2U~MmIPeUnjM4PO4w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":196060,"name":"Antagonist","url":"https://www.academia.edu/Documents/in/Antagonist"},{"id":1954130,"name":"Cell Growth","url":"https://www.academia.edu/Documents/in/Cell_Growth"}],"urls":[{"id":40039173,"url":"https://www.nature.com/articles/s41419-022-05283-w.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797115/XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration"><img alt="Research paper thumbnail of XIAP promotes melanoma growth by inducing tumour neutrophil infiltration" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797115/XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration">XIAP promotes melanoma growth by inducing tumour neutrophil infiltration</a></div><div class="wp-workCard_item"><span>EMBO reports</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently rep...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti-apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro-inflammatory function of XIAP has not yet been considered in cancer. By providing detailed in vitro analyses, utilising two independent mouse melanoma models and including human melanoma samples, we show here that XIAP is an important mediator of melanoma neutrophil infiltration. Neutrophils represent a major driver of melanoma progression and are increasingly considered as a valuable therapeutic target in solid cancer. Our data reveal that XIAP ubiquitylates RIPK2, involve TAB1/RIPK2 complex and induce the transcriptional up-regulation and secretion of chemokines such as IL8, that are responsible for intra-tumour neutrophil accumulation. Alteration of the XIAP-RIPK2-TAB1 inflammatory axis or the depletion of neutrophils in mice reduced melanoma growth. Our data shed new light on how XIAP contributes to tumour growth and provides important insights for novel XIAP targeting strategies in cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797115]").text(description); $(".js-view-count[data-work-id=115797115]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797115; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797115']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797115, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797115]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797115,"title":"XIAP promotes melanoma growth by inducing tumour neutrophil infiltration","translated_title":"","metadata":{"abstract":"Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti-apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro-inflammatory function of XIAP has not yet been considered in cancer. By providing detailed in vitro analyses, utilising two independent mouse melanoma models and including human melanoma samples, we show here that XIAP is an important mediator of melanoma neutrophil infiltration. Neutrophils represent a major driver of melanoma progression and are increasingly considered as a valuable therapeutic target in solid cancer. Our data reveal that XIAP ubiquitylates RIPK2, involve TAB1/RIPK2 complex and induce the transcriptional up-regulation and secretion of chemokines such as IL8, that are responsible for intra-tumour neutrophil accumulation. Alteration of the XIAP-RIPK2-TAB1 inflammatory axis or the depletion of neutrophils in mice reduced melanoma growth. Our data shed new light on how XIAP contributes to tumour growth and provides important insights for novel XIAP targeting strategies in cancer.","publisher":"EMBO","publication_name":"EMBO reports"},"translated_abstract":"Elevated expression of the X-linked inhibitor of apoptosis protein (XIAP) has been frequently reported in malignant melanoma suggesting that XIAP renders apoptosis resistance and thereby supports melanoma progression. Independent of its anti-apoptotic function, XIAP mediates cellular inflammatory signalling and promotes immunity against bacterial infection. The pro-inflammatory function of XIAP has not yet been considered in cancer. By providing detailed in vitro analyses, utilising two independent mouse melanoma models and including human melanoma samples, we show here that XIAP is an important mediator of melanoma neutrophil infiltration. Neutrophils represent a major driver of melanoma progression and are increasingly considered as a valuable therapeutic target in solid cancer. Our data reveal that XIAP ubiquitylates RIPK2, involve TAB1/RIPK2 complex and induce the transcriptional up-regulation and secretion of chemokines such as IL8, that are responsible for intra-tumour neutrophil accumulation. Alteration of the XIAP-RIPK2-TAB1 inflammatory axis or the depletion of neutrophils in mice reduced melanoma growth. Our data shed new light on how XIAP contributes to tumour growth and provides important insights for novel XIAP targeting strategies in cancer.","internal_url":"https://www.academia.edu/115797115/XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration","translated_internal_url":"","created_at":"2024-03-04T19:10:33.648-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"XIAP_promotes_melanoma_growth_by_inducing_tumour_neutrophil_infiltration","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":295234,"name":"Chemokine","url":"https://www.academia.edu/Documents/in/Chemokine"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[{"id":40039172,"url":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.202153608"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797114"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797114/Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling"><img alt="Research paper thumbnail of Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797114/Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling">Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling</a></div><div class="wp-workCard_item"><span>Encyclopedia of Cell Biology</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor of apoptosis or IAP protein family is involved in the control of cell death through a variety of molecular mechanisms. The common aspect of these proteins is the presence of the Baculovirus IAP repeat domain, which is involved in protein–protein interactions with pro-survival and pro-apoptotic proteins. Several IAP proteins also contain a RING domain, which gives them ubiquitin E3 ligase activity and plays a major role in antiapoptotic and pro-survival signaling. Given their importance in regulation of cell survival and signaling, and elevated expression in human malignancies, IAPs are an attractive therapeutic target.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797114"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797114"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797114; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797114]").text(description); $(".js-view-count[data-work-id=115797114]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797114; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797114']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797114, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=115797114]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797114,"title":"Inhibitor of Apoptosis Proteins, the Sentinels of Cell Death and Signaling","translated_title":"","metadata":{"abstract":"Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor of apoptosis or IAP protein family is involved in the control of cell death through a variety of molecular mechanisms. The common aspect of these proteins is the presence of the Baculovirus IAP repeat domain, which is involved in protein–protein interactions with pro-survival and pro-apoptotic proteins. Several IAP proteins also contain a RING domain, which gives them ubiquitin E3 ligase activity and plays a major role in antiapoptotic and pro-survival signaling. Given their importance in regulation of cell survival and signaling, and elevated expression in human malignancies, IAPs are an attractive therapeutic target.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Encyclopedia of Cell Biology"},"translated_abstract":"Efficient regulation of cell death and survival is essential for cellular homeostasis. Inhibitor of apoptosis or IAP protein family is involved in the control of cell death through a variety of molecular mechanisms. The common aspect of these proteins is the presence of the Baculovirus IAP repeat domain, which is involved in protein–protein interactions with pro-survival and pro-apoptotic proteins. Several IAP proteins also contain a RING domain, which gives them ubiquitin E3 ligase activity and plays a major role in antiapoptotic and pro-survival signaling. Given their importance in regulation of cell survival and signaling, and elevated expression in human malignancies, IAPs are an attractive therapeutic target.","internal_url":"https://www.academia.edu/115797114/Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling","translated_internal_url":"","created_at":"2024-03-04T19:10:32.497-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Inhibitor_of_Apoptosis_Proteins_the_Sentinels_of_Cell_Death_and_Signaling","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":55266,"name":"Ubiquitin","url":"https://www.academia.edu/Documents/in/Ubiquitin"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115797094"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115797094/IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization"><img alt="Research paper thumbnail of IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization" class="work-thumbnail" src="https://attachments.academia-assets.com/112103588/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115797094/IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization">IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1b8d7c39d291ce55b08b65bd98b82cd5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112103588,"asset_id":115797094,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112103588/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115797094"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115797094"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115797094; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115797094]").text(description); $(".js-view-count[data-work-id=115797094]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115797094; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115797094']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115797094, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1b8d7c39d291ce55b08b65bd98b82cd5" } } $('.js-work-strip[data-work-id=115797094]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115797094,"title":"IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization","translated_title":"","metadata":{"publisher":"Worldwide Protein Data Bank","publication_date":{"day":null,"month":null,"year":2011,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/115797094/IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization","translated_internal_url":"","created_at":"2024-03-04T19:09:43.471-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":112103588,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103588/thumbnails/1.jpg","file_name":"3t6p_full_validation.pdf","download_url":"https://www.academia.edu/attachments/112103588/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_induced_conformational_ch.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103588/3t6p_full_validation-libre.pdf?1709614416=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_induced_conformational_ch.pdf\u0026Expires=1732409392\u0026Signature=AzV2og0wlOdeRoIaS8nv6tnr~lCje5Rghwfi-vTq9xrfibHMJwCYfI-5bXrSxrz4JDldNBOlFrz68slQHJVi4fGs6xibhJRoXvLoNlzAby6pNfPgxOl6FjbSKFjR3pMq06fKcZk78kJxh1l0W9QFRRvs2s1bcVy0cnh59MAPI0uvvkRvD0acg81oTmn0VdWzyj4WbfWPNehy6FrPqHNM1uAUC90BtwcHlC2VxpmABHx0z7D1GKizuw1peq4wToy2QIdnJXkAsntfLinfXtg8nDo7LDOYd1-2oxFG1fsKdDYXn1fzUCt8vlHc2x9bX2PC0Y-i5kXRVwfQqO8JePC3DQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"IAP_antagonist_induced_conformational_change_in_cIAP1_promotes_E3_ligase_activation_via_dimerization","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":112103588,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112103588/thumbnails/1.jpg","file_name":"3t6p_full_validation.pdf","download_url":"https://www.academia.edu/attachments/112103588/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IAP_antagonist_induced_conformational_ch.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112103588/3t6p_full_validation-libre.pdf?1709614416=\u0026response-content-disposition=attachment%3B+filename%3DIAP_antagonist_induced_conformational_ch.pdf\u0026Expires=1732409392\u0026Signature=AzV2og0wlOdeRoIaS8nv6tnr~lCje5Rghwfi-vTq9xrfibHMJwCYfI-5bXrSxrz4JDldNBOlFrz68slQHJVi4fGs6xibhJRoXvLoNlzAby6pNfPgxOl6FjbSKFjR3pMq06fKcZk78kJxh1l0W9QFRRvs2s1bcVy0cnh59MAPI0uvvkRvD0acg81oTmn0VdWzyj4WbfWPNehy6FrPqHNM1uAUC90BtwcHlC2VxpmABHx0z7D1GKizuw1peq4wToy2QIdnJXkAsntfLinfXtg8nDo7LDOYd1-2oxFG1fsKdDYXn1fzUCt8vlHc2x9bX2PC0Y-i5kXRVwfQqO8JePC3DQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":196060,"name":"Antagonist","url":"https://www.academia.edu/Documents/in/Antagonist"},{"id":482212,"name":"Ubiquitin ligase","url":"https://www.academia.edu/Documents/in/Ubiquitin_ligase"},{"id":784468,"name":"DNA ligase","url":"https://www.academia.edu/Documents/in/DNA_ligase"},{"id":1274450,"name":"Conformational Change","url":"https://www.academia.edu/Documents/in/Conformational_Change"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="109871358"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/109871358/Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells"><img alt="Research paper thumbnail of Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells" class="work-thumbnail" src="https://attachments.academia-assets.com/107865025/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/109871358/Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells">Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediato...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, lung, and head and neck tumors. PAK1 genomic amplification at 11q13 was prevalent in luminal breast cancer, and PAK1 protein expression was associated with lymph node metastasis. Breast cancer cells with PAK1 genomic amplification rapidly underwent apoptosis after inhibition of this kinase. Strong nuclear and cytoplasmic PAK1 expression was also prevalent in squamous nonsmall cell lung carcinomas (NSCLCs), and selective PAK1 inhibition was associated with delayed cell-cycle progression in vi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a8a8a369a1190987c26d683c3d6a7a92" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":107865025,"asset_id":109871358,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/107865025/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="109871358"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="109871358"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 109871358; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=109871358]").text(description); $(".js-view-count[data-work-id=109871358]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 109871358; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='109871358']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 109871358, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a8a8a369a1190987c26d683c3d6a7a92" } } $('.js-work-strip[data-work-id=109871358]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":109871358,"title":"Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells","translated_title":"","metadata":{"abstract":"p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, lung, and head and neck tumors. PAK1 genomic amplification at 11q13 was prevalent in luminal breast cancer, and PAK1 protein expression was associated with lymph node metastasis. Breast cancer cells with PAK1 genomic amplification rapidly underwent apoptosis after inhibition of this kinase. Strong nuclear and cytoplasmic PAK1 expression was also prevalent in squamous nonsmall cell lung carcinomas (NSCLCs), and selective PAK1 inhibition was associated with delayed cell-cycle progression in vi...","publisher":"Proceedings of the National Academy of Sciences","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Proceedings of the National Academy of Sciences"},"translated_abstract":"p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, lung, and head and neck tumors. PAK1 genomic amplification at 11q13 was prevalent in luminal breast cancer, and PAK1 protein expression was associated with lymph node metastasis. Breast cancer cells with PAK1 genomic amplification rapidly underwent apoptosis after inhibition of this kinase. Strong nuclear and cytoplasmic PAK1 expression was also prevalent in squamous nonsmall cell lung carcinomas (NSCLCs), and selective PAK1 inhibition was associated with delayed cell-cycle progression in vi...","internal_url":"https://www.academia.edu/109871358/Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells","translated_internal_url":"","created_at":"2023-11-26T09:17:48.354-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":107865025,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/107865025/thumbnails/1.jpg","file_name":"0579abddebf80cf012ee7a7a00a448df5ebb.pdf","download_url":"https://www.academia.edu/attachments/107865025/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Targeting_p21_activated_kinase_1_PAK1_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/107865025/0579abddebf80cf012ee7a7a00a448df5ebb-libre.pdf?1701019879=\u0026response-content-disposition=attachment%3B+filename%3DTargeting_p21_activated_kinase_1_PAK1_to.pdf\u0026Expires=1732409393\u0026Signature=XRNby9SmfHljamNPeFci--zgk9cdox8TxfkRIq3Y2vp~3OTDbiEZtuX7wuWPSin0em1-Rtv2O8Pc71qMtvB8u5yjOT~xw4jpVR35VE8LIw9JmZ8xN~qAqiSXvu4gmgsnLX2vtQg8~FZXdFuZDmQJsDkfsLQ9Qb3WfUAbok9wBTZNw1v8i7ZTiSrPRdfrv1dMb3I5dQ0mgyXrXdkuGIBVnOBkFfvp96gUeRxO7hmYxrZekEJ7qnnVhN2cW41xl9NYjYlcK4b6Liep6fwgF1nLXBkK9lI7l7IZJh5dS1c~pkC9P8Ku6ZZAGQ7IfZM2hzlKe2mji9CQ5MpRC7ZakmauuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Targeting_p21_activated_kinase_1_PAK1_to_induce_apoptosis_of_tumor_cells","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[{"id":107865025,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/107865025/thumbnails/1.jpg","file_name":"0579abddebf80cf012ee7a7a00a448df5ebb.pdf","download_url":"https://www.academia.edu/attachments/107865025/download_file?st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&st=MTczMjQwNTc5Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Targeting_p21_activated_kinase_1_PAK1_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/107865025/0579abddebf80cf012ee7a7a00a448df5ebb-libre.pdf?1701019879=\u0026response-content-disposition=attachment%3B+filename%3DTargeting_p21_activated_kinase_1_PAK1_to.pdf\u0026Expires=1732409393\u0026Signature=XRNby9SmfHljamNPeFci--zgk9cdox8TxfkRIq3Y2vp~3OTDbiEZtuX7wuWPSin0em1-Rtv2O8Pc71qMtvB8u5yjOT~xw4jpVR35VE8LIw9JmZ8xN~qAqiSXvu4gmgsnLX2vtQg8~FZXdFuZDmQJsDkfsLQ9Qb3WfUAbok9wBTZNw1v8i7ZTiSrPRdfrv1dMb3I5dQ0mgyXrXdkuGIBVnOBkFfvp96gUeRxO7hmYxrZekEJ7qnnVhN2cW41xl9NYjYlcK4b6Liep6fwgF1nLXBkK9lI7l7IZJh5dS1c~pkC9P8Ku6ZZAGQ7IfZM2hzlKe2mji9CQ5MpRC7ZakmauuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":340262,"name":"Carcinogenesis","url":"https://www.academia.edu/Documents/in/Carcinogenesis"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":485892,"name":"CDC","url":"https://www.academia.edu/Documents/in/CDC"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":2068869,"name":"Academy of Sciences and Letters","url":"https://www.academia.edu/Documents/in/Academy_of_Sciences_and_Letters"},{"id":2079216,"name":"Lymph nodes","url":"https://www.academia.edu/Documents/in/Lymph_nodes"}],"urls":[{"id":35908661,"url":"https://pnas.org/doi/pdf/10.1073/pnas.1103350108"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="104444436"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/104444436/Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas"><img alt="Research paper thumbnail of Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/104444436/Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas">Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcriptio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="104444436"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="104444436"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 104444436; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=104444436]").text(description); $(".js-view-count[data-work-id=104444436]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 104444436; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='104444436']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 104444436, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=104444436]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":104444436,"title":"Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","translated_title":"","metadata":{"abstract":"Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","publisher":"American Association for Cancer Research (AACR)"},"translated_abstract":"Supplementary Methods, Tables 1-3, Figure Legends 1-3 from Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas","internal_url":"https://www.academia.edu/104444436/Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_internal_url":"","created_at":"2023-07-10T16:33:51.727-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33147969,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Supplementary_Methods_Tables_1_3_Figure_Legends_1_3_from_Microphthalmia_Associated_Transcription_Factor_Is_a_Critical_Transcriptional_Regulator_of_Melanoma_Inhibitor_of_Apoptosis_in_Melanomas","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33147969,"first_name":"Domagoj","middle_initials":null,"last_name":"Vucic","page_name":"DomagojVucic","domain_name":"independent","created_at":"2015-07-17T15:57:54.432-07:00","display_name":"Domagoj Vucic","url":"https://independent.academia.edu/DomagojVucic"},"attachments":[],"research_interests":[{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":213901,"name":"Transcription Factor","url":"https://www.academia.edu/Documents/in/Transcription_Factor"},{"id":705414,"name":"Regulator","url":"https://www.academia.edu/Documents/in/Regulator"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "7d8446f2b29a83d8fbbc9b14beda718cd91717878cd437bb4d0257531fd83c6a", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="T/GjG9njf52pX6b11hODcUvMXF5t56LBNqdJSDUzENZl9BNiGQbXnNDkvynr+6MTMWiS8fOHCbLGJ7ZpjRFbDg==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/DomagojVucic" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="avdXX4q4e+N/pFWK+LrtPEkkRNEoaY0Wfh9vXZtcLHZA8ucmSl3T4gYfTFbFUs1eM4CKfrYJJmWOn5B8I35nrg==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>