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sequences</b></a></li><li class="top_level"><img src="/i/leaf.gif" class="toggle expression.html" alt=""><a href="expression.html"><b>Gene Expression</b></a></li><li class="top_level"><img src="/i/leaf.gif" class="toggle compara.html" alt=""><a href="compara.html"><b>Compare genes across species</b></a></li><li class="top_level"><img src="/i/leaf.gif" class="toggle gene_snps.html" alt=""><a href="gene_snps.html"><b>Variants for my gene</b></a></li><li class="top_level"><img src="/i/leaf.gif" class="toggle phenotype.html" alt=""><a href="phenotype.html"><b>Diseases and Phenotypes</b></a></li><li class="top_level"><img src="/i/leaf.gif" class="toggle grch37.html" alt=""><a href="grch37.html"><b>The GRCh37 assembly in Ensembl</b></a></li><li class="last"><img src="/i/leaf.gif" class="toggle userdata.html" alt=""><a href="userdata.html"><b>Use my own data</b></a></li> </ul> <div class="js_panel" style="margin:16px 0 0 8px"> <input type="hidden" class="panel_type" value="SearchBox" /> <form 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species</h1> </div> <div class="column-wrapper"> <div class="column-two"> <div class="column-left"> <h2>Gene Trees and Homologues</h2> <p>A representative protein for every gene in Ensembl across all species is used to determine <a href="/Homo_sapiens/Gene/Compara_Tree?g=ENSG00000171105;r=19:7112266-7294045">gene trees</a> and homologues.</a> <a href="/Homo_sapiens/Gene/Compara_Tree?g=ENSG00000171105;r=19:7112266-7294045"><img src="/img/compara_fig_1.jpg" class="screenshot"></a> <p>Homologues are separated into <a href="/Homo_sapiens/Gene/Compara_Ortholog?g=ENSG00000171105;r=19:7112266-7294045">Orthologues</a> (across different species) and <a href="/Homo_sapiens/Gene/Compara_Paralog?g=ENSG00000171105;r=19:7112266-7294045">Paralogues</a> (within a species).</p> <div class="screenshot center small"> <a href="/Homo_sapiens/Gene/Compara_Ortholog?g=ENSG00000171105;r=19:7112266-7294045"><img src="/img/compara_fig_2_thumb.jpg" class="screenshot"></a> <a href="/img/compara_fig_2.jpg">[Click to enlarge]</a> </div> <p>Find out more:</p> <ul> <li><a href="/Help/View?id=137">Gene Tree help page</a></li> <li><a href="/Help/View?id=135">Orthologues help page</a></li> <li><a href="/info/genome/compara/homology_method.html">Gene trees and homology</a></li> <li><a href="/info/genome/compara/">Compara documentation</a></li> </ul> <a href="/Help/Movie?id=423" class="popup"><img src="/img/movie_423.png" class="screenshot"></a> </div> </div> <div class="column-two"> <div class="column-right" style="padding-left:2em"> <h2>Sequence alignments</h2> <p>Whole genome alignments are determined as part of the Ensembl release cycle, incorporating new species and new assemblies when they are made available in our website.</p> <p>Compare species in the <a href="/Homo_sapiens/Gene/Compara_Alignments?align=1134&db=core&g=ENSG00000171105&r=19:7112266-7294045">genomic alignment view</a>:</p> <div class="screenshot center small"> <a href="/Homo_sapiens/Gene/Compara_Alignments?align=756;db=core;g=ENSG00000171105;r=19:7112266-7294045"><img src="/img/compara_fig_3_thumb.jpg" class="screenshot"></a> <a href="/img/compara_fig_3.jpg">[Click to enlarge]</a> </div> <p><a href="/Homo_sapiens/Location/Compara_Alignments/Image?align=756;db=core;g=ENSG00000171105;r=19:7112266-7294045">Alignments (image)</a>:</p> <div class="screenshot center small"> <a href="/Homo_sapiens/Location/Compara_Alignments/Image?align=756;db=core;r=19:7112266-7294045"><img src="/img/compara_fig_4_thumb.jpg" class="screenshot"></a> <a href="/img/compara_fig_4.jpg">[Click to enlarge]</a> </div> <p><a href="/Homo_sapiens/Location/Multi?db=core;g=ENSG00000171105;r=19:7112266-7294045;r1=19:7159714-7341493:1;s1=Pan_troglodytes">Region comparison</a>:</p> <div class="screenshot center small"> <a href="/Homo_sapiens/Location/Multi?db=core;g=ENSG00000171105;r=19:7112266-7294045;r1=19:7159714-7341493:1;s1=Pan_troglodytes"><img src="/img/compara_fig_5_thumb.jpg" class="screenshot"></a> <a href="/img/compara_fig_5.jpg">[Click to enlarge]</a> </div> <p>or the conservation track in Region in Detail:</p> <div class="screenshot center small"> <a href="/Homo_sapiens/Location/View?db=core;g=ENSG00000171105;r=19:7112266-7294045;contigviewbottom=alignment_compara_781_scores=tiling"><img src="/img/compara_fig_6_thumb.jpg" class="screenshot"></a> <a href="/img/compara_fig_6.jpg">[Click to enlarge]</a> </div> </div> </div> </div> </div> </div></div> </div> <div id="footer"> <div class="column-wrapper"> <div class="column-two left"> <p>Ensembl release 113 - October 2024 © <span class="print_hide"><a href="http://www.ebi.ac.uk/" class="nowrap constant">EMBL-EBI</a></span> <span class="screen_hide_inline">EMBL-EBI<br />http://useast.ensembl.org</span> </p> </div> <div class="column-two right print_hide"><p> <a class="modal_link" id="p_link" href="/Help/Permalink?url=http%3A%2F%2FOct2024.archive.ensembl.org">Permanent 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value=Mus_musculus_NZO_HlLtJ|Cyprinodon_variegatus|Panthera_leo|Homo_sapiens|Sus_scrofa_hampshire|Sorex_araneus|Microcebus_murinus|Danio_rerio|Ursus_americanus|Panthera_tigris_altaica|Sus_scrofa_ningxiang|Sinocyclocheilus_grahami|Cavia_aperea|Strix_occidentalis_caurina|Takifugu_rubripes|Scleropages_formosus|Choloepus_hoffmanni|Sus_scrofa_ossabaw_miniature|Ovis_aries_rambouillet|Sus_scrofa_pietrain|Stegastes_partitus|Seriola_lalandi_dorsalis|Poecilia_reticulata|Bos_mutus|Nothobranchius_furzeri|Mus_musculus_C3H_HeJ|Gallus_gallus|Cricetulus_griseus_picr|Sus_scrofa_usmarc|Gallus_gallus_GCA_000002315.5|Sciurus_vulgaris|Gadus_morhua_celtic_sea|Oryzias_latipes_hni|Astyanax_mexicanus|Vombatus_ursinus|Sus_scrofa_pb115|Pavo_cristatus|Gallus_gallus_GCA_016700215.2|Electrophorus_electricus|Salmo_trutta|Crocodylus_porosus|Catagonus_wagneri|Salmo_salar|Loxodonta_africana|Ailuropoda_melanoleuca|Mus_musculus_C57BL_6NJ|Saimiri_boliviensis_boliviensis|Capra_hircus_saanen_dairy|Anas_zonorhyncha|Gasterosteus_aculeatus_freshwater_bot|Podarcis_muralis|Cyclopterus_lumpus|Apteryx_haastii|Sus_scrofa_bama_miniature|Taeniopygia_guttata|Oreochromis_niloticus|Sus_scrofa_rongchang|Lates_calcarifer|Lynx_canadensis|Oryzias_javanicus|Corvus_moneduloides|Theropithecus_gelada|Macaca_nemestrina|Sus_scrofa_nihs_2020|Rhinopithecus_roxellana|Capra_hircus|Eptatretus_burgeri|Canis_lupus_familiarisboxer|Leptobrachium_leishanense|Oryzias_latipes|Acanthochromis_polyacanthus|Strigops_habroptila|Junco_hyemalis|Anolis_carolinensis|Mus_caroli|Rattus_norvegicus_SHRUtx|Ursus_thibetanus_thibetanus|Accipiter_nisus|Ovis_aries_kermani|Mus_spretus|Cervus_hanglu_yarkandensis|Propithecus_coquereli|Sus_scrofa_meishan|Ovis_aries_white_dorper|Nothoprocta_perdicaria|Rhinopithecus_bieti|Sus_scrofa_berkshire|Pan_paniscus|Echinops_telfairi|Tetraodon_nigroviridis|Varanus_komodoensis|Piliocolobus_tephrosceles|Spermophilus_dauricus|Oryzias_melastigma|Gorilla_gorilla|Neogobius_melanostomus|Parus_major|Tupaia_belangeri|Lepisosteus_oculatus|Coturnix_japonica|Papio_anubis|Nomascus_leucogenys|Poecilia_latipinna|Esox_lucius|Drosophila_melanogaster|Chlorocebus_sabaeus|Meriones_unguiculatus|Sus_scrofa_euw1|Meleagris_gallopavo|Delphinapterus_leucas|Sphaeramia_orbicularis|Macaca_fascicularis|Oreochromis_aureus|Mus_musculus_CAST_EiJ|Gadus_morhua|Amazona_collaria|Poecilia_mexicana|Oryctolagus_cuniculus|Gouania_willdenowi|Nannospalax_galili|Oryzias_latipes_hsok|Dicentrarchus_labrax|Parambassis_ranga|Scophthalmus_maximus|Serinus_canaria|Buteo_japonicus|Otolemur_garnettii|Mus_musculus_A_J|Calidris_pugnax|Sus_scrofa_meishan_GCA_017957985.1|Laticauda_laticaudata|Melopsittacus_undulatus|Pongo_abelii|Anas_platyrhynchos_platyrhynchos|Hucho_hucho|Pseudonaja_textilis|Vulpes_vulpes|Malurus_cyaneus_samueli|Betta_splendens|Amphiprion_percula|Callorhinchus_milii|Oncorhynchus_mykiss|Chinchilla_lanigera|Ciona_savignyi|Gasterosteus_aculeatus|Gambusia_affinis|Oncorhynchus_tshawytscha|Catharus_ustulatus|Sus_scrofa_tibetan|Neovison_vison|Pelusios_castaneus|Otus_sunia|Camarhynchus_parvulus|Erinaceus_europaeus|Labrus_bergylta|Numida_meleagris|Mandrillus_leucophaeus|Petromyzon_marinus|Phocoena_sinus|Mus_musculus_PWK_PhJ|Canis_lupus_familiaris|Rattus_norvegicus_SHRSPBbbUtx|Erpetoichthys_calabaricus|Amphiprion_ocellaris|Cyprinus_carpio_hebao_red|Capra_hircus_xinong_saanen_dairy|Astyanax_mexicanus_pachon|Cricetulus_griseus_chok1gshd|Athene_cunicularia|Vicugna_pacos|Zonotrichia_albicollis|Cavia_porcellus|Pelodiscus_sinensis|Canis_lupus_familiarisgreatdane|Struthio_camelus_australis|Bos_grunniens|Equus_caballus|Ovis_aries_texel|Calidris_pygmaea|Gopherus_agassizii|Mus_spicilegus|Latimeria_chalumnae|Mustela_putorius_furo|Naja_naja|Xiphophorus_maculatus|Denticeps_clupeoides|Felis_catus|Octodon_degus|Ovis_aries_east_friesian|Mus_musculus_BALB_cJ|Echeneis_naucrates|Chrysemys_picta_bellii|Sinocyclocheilus_anshuiensis|Cynoglossus_semilaevis|Oryzias_sinensis|Ovis_aries_chinese_merino|Camelus_dromedarius|Sander_lucioperca|Monodelphis_domestica|Mola_mola|Marmota_marmota_marmota|Cairina_moschata_domestica|Sinocyclocheilus_rhinocerous|Canis_lupus_dingo|Chelonoidis_abingdonii|Astatotilapia_calliptera|Xiphophorus_couchianus|Cyprinus_carpio_huanghe|Ciona_intestinalis|Heterocephalus_glaber_female|Gasterosteus_aculeatus_marine_bam|Microtus_ochrogaster|Stachyris_ruficeps|Sarcophilus_harrisii|Sus_scrofa_wuzhishan|Salmo_salar_north_american_atlantic_salmon|Panthera_pardus|Chrysolophus_pictus|Ictalurus_punctatus|Fundulus_heteroclitus|Poecilia_formosa|Colobus_angolensis_palliatus|Mus_musculus_LP_J|Mesocricetus_auratus|Paramormyrops_kingsleyae|Saccharomyces_cerevisiae|Rattus_norvegicus|Ovis_aries_polled_dorset|Mus_musculus_AKR_J|Apteryx_rowi|Dipodomys_ordii|Notamacropus_eugenii|Capra_hircus_blackbengal|Myripristis_murdjan|Gasterosteus_aculeatus_marine_syl|Hippocampus_comes|Ficedula_albicollis|Monopterus_albus|Sus_scrofa_duroc|Mus_musculus_DBA_2J|Aotus_nancymaae|Carassius_auratus|Physeter_catodon|Ursus_maritimus|Castor_canadensis|Cyprinus_carpio_carpio|Heterocephalus_glaber_male|Anser_cygnoides|Clupea_harengus|Moschus_moschiferus|Falco_tinnunculus|Dasypus_novemcinctus|Myotis_lucifugus|Cyprinus_carpio_german_mirror|Terrapene_carolina_triunguis|Apteryx_owenii|Oncorhynchus_kisutch|Anabas_testudineus|Monodon_monoceros|Bos_taurus_hybrid|Balaenoptera_musculus|Chelydra_serpentina|Bubo_bubo|Jaculus_jaculus|Ovis_aries_hu|Sus_scrofa_bamei|Anser_brachyrhynchus|Fukomys_damarensis|Sus_scrofa_landrace|Mus_musculus_CBA_J|Prolemur_simus|Sus_scrofa_jinhua|Mus_musculus_WSB_EiJ|Sphenodon_punctatus|Xenopus_tropicalis|Maylandia_zebra|Geospiza_fortis|Mus_pahari|Caenorhabditis_elegans|Mus_musculus|Kryptolebias_marmoratus|Callithrix_jacchus|Aquila_chrysaetos_chrysaetos|Lonchura_striata_domestica|Ovis_aries_romanov|Cyanistes_caeruleus|Macaca_mulatta|Notechis_scutatus|Dromaius_novaehollandiae|Urocitellus_parryii|Bison_bison_bison|Mus_musculus_FVB_NJ|Rhinolophus_ferrumequinum|Amphilophus_citrinellus|Manacus_vitellinus|Mus_musculus_129S1_SvImJ|Anas_platyrhynchos|Rattus_norvegicus_WKYBbb|Sus_scrofa|Sus_scrofa_largewhite|Salmo_salar_european_origin_alta|Cricetulus_griseus_crigri|Zosterops_lateralis_melanops|Canis_lupus_familiarisbasenji|Tursiops_truncatus|Suricata_suricatta|Larimichthys_crocea|Mastacembelus_armatus|Equus_asinus|Cebus_imitator|Salmo_salar_north_american_origin_brian|Haplochromis_burtoni|Pogona_vitticeps|Carlito_syrichta|Pan_troglodytes|Phasianus_colchicus|Mus_musculus_NOD_ShiLtJ|Bos_taurus|Sparus_aurata|Canis_lupus_familiarisgermanshepherd|Ochotona_princeps|Neolamprologus_brichardi|Lepidothrix_coronata|Ictidomys_tridecemlineatus|Salvator_merianae|Ovis_aries_qiaoke|Pundamilia_nyererei|Bos_indicus_hybrid|Cottoperca_gobio|Peromyscus_maniculatus_bairdii|Periophthalmus_magnuspinnatus|Gopherus_evgoodei|Pteropus_vampyrus|Phascolarctos_cinereus|Procavia_capensis|Cercocebus_atys|Erythrura_gouldiae|Salarias_fasciatus|Zalophus_californianus|Seriola_dumerili|Pygocentrus_nattereri|Ornithorhynchus_anatinus> 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