Biomedical Materials

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aria-selected="false" aria-controls="review-articles-tab" id="review-articles" class="event_tabs" tabindex="-1"> Review articles </button> <button role="tab" aria-selected="false" aria-controls="accepted-manuscripts-tab" id="accepted-manuscripts" class="event_tabs" tabindex="-1"> Accepted manuscripts </button> <button role="tab" aria-selected="false" aria-controls="open-access-articles-tab" id="open-access-articles" class="event_tabs" tabindex="-1"> Open Access </button> </div>   <div tabindex="0" role="tabpanel" id="most-read-tab" aria-labelledby="most-read" hidden="hidden"> <div class=" reveal-container reveal-closed reveal-enabled reveal-container--jnl-tab"> <h2 class="tabpanel__title"> <button type="button" class="reveal-trigger event_tabs-accordion" aria-expanded="false"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg>Most read</button> </h2> <div class="reveal-content tabpanel__content" style="display: none"> <p> <button data-reveal-label-alt="Close all abstracts" class="reveal-all-trigger mr-2 small" data-reveal-text="Open all abstracts" data-link-purpose-append="in this tab" data-link-purpose-append-open="in this tab"> Open all abstracts<span class="offscreen-hidden">, in this tab</span> </button> </p>  <div class="art-list"> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/acd672" class="art-list-item-title event_main-link">Recent advances in horizontal alveolar bone regeneration</a> <p class="small art-list-item-meta"> Tiancheng Li <em>et al</em> 2023 <em>Biomed. Mater.</em> <b>18</b> 052004 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Recent advances in horizontal alveolar bone regeneration" data-link-purpose-append-open="Recent advances in horizontal alveolar bone regeneration">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/acd672/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Recent advances in horizontal alveolar bone regeneration</span></a> <a href="/article/10.1088/1748-605X/acd672/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Recent advances in horizontal alveolar bone regeneration</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Alveolar bone loss is widespread in all age groups and remains a severe hazard to periodontal health. Horizontal alveolar bone loss is the pattern of bone loss more commonly seen in periodontitis. Until now, limited regenerative procedures have been applied to treating horizontal alveolar bone loss in periodontal clinics, making it the least predictable periodontal defect type. This article reviews the literature on recent advances in horizontal alveolar bone regeneration. The biomaterials and clinical and preclinical approaches tested for the regeneration of the horizontal type of alveolar bone are first discussed. Furthermore, current obstacles for horizontal alveolar bone regeneration and future directions in regenerative therapy are presented to provide new ideas for developing an effective multidisciplinary strategy to address the challenge of horizontal alveolar bone loss.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/acd672">https://doi.org/10.1088/1748-605X/acd672</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad76f1" class="art-list-item-title event_main-link">Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma</a> <p class="small art-list-item-meta"> Shirin B Hanaei <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065008 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma" data-link-purpose-append-open="Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad76f1/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma</span></a> <a href="/article/10.1088/1748-605X/ad76f1/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Osteosarcoma (OS) is the mostly commonly occurring primary bone cancer. Despite comprehensive treatment programs including neoadjuvant chemotherapy and tumour resection, survival rates have not improved significantly since the 1970s. Survival rates are dramatically reduced for patients who suffer a local recurrence. Furthermore, primary bone cancer patients are at increased risk of bone fractures. Consequently, there is an urgent need for alternative treatment options. In this paper we report the development of novel gallium doped bioactive glass that selectively kill bone cancer cells whilst simultaneously stimulating new bone growth. Here we show, using a combination of 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide, LIVE/DEAD assays and image analysis, that bioactive glasses containing gallium oxide are highly toxic and reduce both the proliferation and migration of bone cancer cells (Saos-2) in a dose dependant manner. Glasses containing 5 mol% gallium oxide reduced the viability of OS cells by 99% without being cytotoxic to the non-cancerous normal human osteoblasts (NHOst) control cells. Furthermore, Fourier transform infrared and energy-dispersive x-ray spectroscopy results confirmed the formation of an amorphous calcium phosphate/hydroxyapatite like layer on the surface of the bioactive glass particulates, after 7 d incubating in simulated body fluid, indicating the early stages of bone formation. These materials show significant potential for use in bone cancer applications as part of a multimodal treatment.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad76f1">https://doi.org/10.1088/1748-605X/ad76f1</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/acd316" class="art-list-item-title event_main-link">The chicken eggshell membrane: a versatile, sustainable, biological material for translational biomedical applications</a> <p class="small art-list-item-meta"> Rosemond A Mensah <em>et al</em> 2023 <em>Biomed. Mater.</em> <b>18</b> 042001 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="The chicken eggshell membrane: a versatile, sustainable, biological material for translational biomedical applications" data-link-purpose-append-open="The chicken eggshell membrane: a versatile, sustainable, biological material for translational biomedical applications">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/acd316/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, The chicken eggshell membrane: a versatile, sustainable, biological material for translational biomedical applications</span></a> <a href="/article/10.1088/1748-605X/acd316/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, The chicken eggshell membrane: a versatile, sustainable, biological material for translational biomedical applications</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Naturally derived materials are often preferred over synthetic materials for biomedical applications due to their innate biological characteristics, relative availability, sustainability, and agreement with conscientious end-users. The chicken eggshell membrane (ESM) is an abundant resource with a defined structural profile, chemical composition, and validated morphological and mechanical characteristics. These unique properties have not only allowed the ESM to be exploited within the food industry but has also led to it be considered for other novel translational applications such as tissue regeneration and replacement, wound healing and drug delivery. However, challenges still exist in order to enhance the native ESM (nESM): the need to improve its mechanical properties, the ability to combine/join fragments of ESM together, and the addition or incorporation of drugs/growth factors to advance its therapeutic capacity. This review article provides a succinct background to the nESM, its extraction, isolation, and consequent physical, mechanical and biological characterisation including possible approaches to enhancement. Moreover, it also highlights current applications of the ESM in regenerative medicine and hints at future novel applications in which this novel biomaterial could be exploited to beneficial use.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/acd316">https://doi.org/10.1088/1748-605X/acd316</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/acd03f" class="art-list-item-title event_main-link">The antimicrobial efficacy of copper, cobalt, zinc and silver nanoparticles: alone and in combination</a> <p class="small art-list-item-meta"> Farah N S Raja <em>et al</em> 2023 <em>Biomed. Mater.</em> <b>18</b> 045003 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="The antimicrobial efficacy of copper, cobalt, zinc and silver nanoparticles: alone and in combination" data-link-purpose-append-open="The antimicrobial efficacy of copper, cobalt, zinc and silver nanoparticles: alone and in combination">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/acd03f/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, The antimicrobial efficacy of copper, cobalt, zinc and silver nanoparticles: alone and in combination</span></a> <a href="/article/10.1088/1748-605X/acd03f/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, The antimicrobial efficacy of copper, cobalt, zinc and silver nanoparticles: alone and in combination</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>With the advent of nanotechnology, there has been an extensive interest in the antimicrobial potential of metals. The rapid and widespread development of antimicrobial-resistant and multidrug-resistant bacteria has prompted recent research into developing novel or alternative antimicrobial agents. In this study, the antimicrobial efficacy of metallic copper, cobalt, silver and zinc nanoparticles was assessed against <i>Escherichia coli</i> (NCTC 10538), <i>S. aureus</i> (ATCC 6538) along with three clinical isolates of <i>Staphylococcus epidermidis</i> (A37, A57 and A91) and three clinical isolates of <i>E. coli</i> (Strains 1, 2 and 3) recovered from bone marrow transplant patients and patients with cystitis respectively. Antimicrobial sensitivity assays, including agar diffusion and broth macro-dilution to determine minimum inhibitory and bactericidal concentrations (MIC/MBC) and time-kill/synergy assays, were used to assess the antimicrobial efficacy of the agents. The panel of test microorganisms, including antibiotic-resistant strains, demonstrated a broad range of sensitivity to the metals investigated. MICs of the type culture strains were in the range of 0.625–5.0 mg ml<sup>−1</sup>. While copper and cobalt exhibited no difference in sensitivity between Gram-positive and Gram-negative microorganisms, silver and zinc showed strain specificity. A significant decrease (<i>p</i> < 0.001) in the bacterial density of <i>E. coli</i> and <i>S. aureus</i> was demonstrated by silver, copper and zinc in as little as two hours. Furthermore, combining metal nanoparticles reduced the time required to achieve a complete kill.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/acd03f">https://doi.org/10.1088/1748-605X/acd03f</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/acf976" class="art-list-item-title event_main-link">Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment</a> <p class="small art-list-item-meta"> Clare L Thompson <em>et al</em> 2023 <em>Biomed. Mater.</em> <b>18</b> 065013 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment" data-link-purpose-append-open="Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/acf976/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment</span></a> <a href="/article/10.1088/1748-605X/acf976/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis and osteoarthritis. Thus, the synovium is a promising target for the development of novel, disease-modifying therapeutics. However, target exploration is hampered by a lack of good pre-clinical models that accurately replicate human physiology and that are developed in a way that allows for widespread uptake. The current study presents a multi-channel, microfluidic, organ-on-a-chip (OOAC) model, comprising a 3D configuration of the human synovium and its associated vasculature, with biomechanical and inflammatory stimulation, built upon a commercially available OOAC platform. Healthy human fibroblast-like synoviocytes (hFLS) were co-cultured with human umbilical vein endothelial cells (HUVECs) with appropriate matrix proteins, separated by a flexible, porous membrane. The model was developed within the Emulate organ-chip platform enabling the application of physiological biomechanical stimulation in the form of fluid shear and cyclic tensile strain. The hFLS exhibited characteristic morphology, cytoskeletal architecture and matrix protein deposition. Synovial inflammation was initiated through the addition of interleukin−1<i>β</i> (IL−1<i>β</i>) into the synovium channel resulting in the increased secretion of inflammatory and catabolic mediators, interleukin-6 (IL−6), prostaglandin E2 (PGE<sub>2</sub>), matrix metalloproteinase 1 (MMP−1), as well as the synovial fluid constituent protein, hyaluronan. Enhanced expression of the inflammatory marker, intercellular adhesion molecule-1 (ICAM-1), was observed in HUVECs in the vascular channel, accompanied by increased attachment of circulating monocytes. This vascularised human synovium-on-a-chip model recapitulates a number of the functional characteristics of both healthy and inflamed human synovium. Thus, this model offers the first human synovium organ-chip suitable for widespread adoption to understand synovial joint disease mechanisms, permit the identification of novel therapeutic targets and support pre-clinical testing of therapies.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/acf976">https://doi.org/10.1088/1748-605X/acf976</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ac2b7a" class="art-list-item-title event_main-link">Mechanical properties of whole-body soft human tissues: a review</a> <p class="small art-list-item-meta"> Gurpreet Singh and Arnab Chanda 2021 <em>Biomed. Mater.</em> <b>16</b> 062004 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Mechanical properties of whole-body soft human tissues: a review" data-link-purpose-append-open="Mechanical properties of whole-body soft human tissues: a review">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ac2b7a/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Mechanical properties of whole-body soft human tissues: a review</span></a> <a href="/article/10.1088/1748-605X/ac2b7a/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Mechanical properties of whole-body soft human tissues: a review</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The mechanical properties of soft tissues play a key role in studying human injuries and their mitigation strategies. While such properties are indispensable for computational modelling of biological systems, they serve as important references in loading and failure experiments, and also for the development of tissue simulants. To date, experimental studies have measured the mechanical properties of peripheral tissues (e.g. skin) <i>in-vivo</i> and limited internal tissues <i>ex-vivo</i> in cadavers (e.g. brain and the heart). The lack of knowledge on a majority of human tissues inhibit their study for applications ranging from surgical planning, ballistic testing, implantable medical device development, and the assessment of traumatic injuries. The purpose of this work is to overcome such challenges through an extensive review of the literature reporting the mechanical properties of whole-body soft tissues from head to toe. Specifically, the available linear mechanical properties of all human tissues were compiled. Non-linear biomechanical models were also introduced, and the soft human tissues characterized using such models were summarized. The literature gaps identified from this work will help future biomechanical studies on soft human tissue characterization and the development of accurate medical models for the study and mitigation of injuries.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ac2b7a">https://doi.org/10.1088/1748-605X/ac2b7a</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad8828" class="art-list-item-title event_main-link">Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture</a> <p class="small art-list-item-meta"> Ruya Zhang <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065036 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture" data-link-purpose-append-open="Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8828/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture</span></a> <a href="/article/10.1088/1748-605X/ad8828/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The mechanical competence and suturing ability of collagen-based membranes are paramount in guided bone regeneration (GBR) therapy, to ensure damage-free implantation, fixation and space maintenance <i>in vivo</i>. However, contact with the biological medium can induce swelling of collagen molecules, yielding risks of membrane sinking into the bone defect, early loss of barrier function, and irreversibly compromised clinical outcomes. To address these challenges, this study investigates the effect of the crosslinked network architecture on both mechanical and suture-holding properties of a new atelocollagen (AC) membrane. UV-cured networks were obtained via either single functionalisation of AC with 4-vinylbenzyl chloride (4VBC) or sequential functionalisation of AC with both 4VBC and methacrylic anhydride. The wet-state compression modulus (<i>E</i><sub>c</sub>) and swelling ratio (SR) were significantly affected by the UV-cured network architecture, leading up to a three-fold reduction in SR and about two-fold increase in <i>E</i><sub>c</sub> in the sequentially functionalised, compared to the single-functionalised, samples. Electron microscopy, dimensional analysis and compression testing revealed the direct impact of the ethanol series dehydration process on membrane microstructure, yielding densification of the freshly synthesised porous samples and a pore-free microstructure with increased <i>E</i><sub>c</sub>. Nanoindentation tests via spherical bead-probe atomic force microscopy (AFM) confirmed an approximately two-fold increase in median (interquartile range (IQR)) elastic modulus in the sequentially functionalised (<i>E</i><sub>AFM</sub> = 40 (13) kPa), with respect to single-functionalised (<i>E</i><sub>AFM</sub> = 15 (9) kPa), variants. Noteworthy, the single-functionalised, but not the sequentially functionalised, samples displayed higher suture retention strength (SRS = 28 ± 2–35 ± 10 N<img src="https://cdn.images.iop.org/Entities/bdot.gif" alt="bold dot" align="absmiddle" />mm<sup>−1</sup>) in both the dry state and following 1 h in phosphate buffered saline (PBS), compared to Bio-Gide® (SRS: 6 ± 1–14 ± 2 N<img src="https://cdn.images.iop.org/Entities/bdot.gif" alt="bold dot" align="absmiddle" />mm<sup>−1</sup>), while a significant decrease was measured after 24 h in PBS (SRS= 1 ± 1 N<img src="https://cdn.images.iop.org/Entities/bdot.gif" alt="bold dot" align="absmiddle" />mm<sup>−1</sup>). These structure-property relationships confirm the key role played by the molecular architecture of covalently crosslinked collagen, aimed towards long-lasting resorbable membranes for predictable GBR therapy.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8828">https://doi.org/10.1088/1748-605X/ad8828</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7562" class="art-list-item-title event_main-link">Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing</a> <p class="small art-list-item-meta"> L Scaccini <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065005 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing" data-link-purpose-append-open="Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7562/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing</span></a> <a href="/article/10.1088/1748-605X/ad7562/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Regenerative medicine is continuously looking for new natural, biocompatible and possibly biodegradable materials, but also mechanically compliant. Chitosan is emerging as a promising FDA-approved biopolymer for tissue engineering, however, its exploitation in regenerative devices is limited by its brittleness and can be further improved, for example by blending it with other materials or by tuning its superficial microstructure. Here, we developed membranes made of chitosan (Chi) and glycerol, by solvent casting, and micro-patterned them with directional geometries having different levels of axial symmetry. These membranes were characterized by light microscopies, atomic force microscopy (AFM), by thermal, mechanical and degradation assays, and also tested <i>in vitro</i> as scaffolds with Schwann cells (SCs). The glycerol-blended Chi membranes are optimized in terms of mechanical properties, and present a physiological-grade Young's modulus (≈0.7 MPa). The directional topographies are effective in directing cell polarization and migration and in particular are highly performant substrates for collective cell migration. Here, we demonstrate that a combination of a soft compliant biomaterial and a topographical micropatterning can improve the integration of these scaffolds with SCs, a fundamental step in the peripheral nerve regeneration process.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7562">https://doi.org/10.1088/1748-605X/ad7562</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7e6f" class="art-list-item-title event_main-link">MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner</a> <p class="small art-list-item-meta"> Iaroslav B Belyaev <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065022 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner" data-link-purpose-append-open="MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7e6f/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner</span></a> <a href="/article/10.1088/1748-605X/ad7e6f/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Pharmacokinetics of nanomedicines can be improved by a temporal blockade of mononuclear phagocyte system (MPS) through the interaction with other biocompatible nanoparticles. Liposomes are excellent candidates as blocking agents, but the efficiency of the MPS blockade can greatly depend on the liposome properties. Here, we investigated the dependence of the efficiency of the induced MPS blockade <i>in vitro</i> and <i>in vivo</i> on the size of blocking liposomes in the 100–500 nm range. Saturation of RAW 264.7 macrophage uptake was observed for phosphatidylcholine/cholesterol liposomes larger than 200 nm <i>in vitro</i>. In mice, liposomes of all sizes exhibited a blocking effect on liver macrophages, prolonging the circulation of subsequently administrated magnetic nanoparticles in the bloodstream, reducing their liver uptake, and increasing accumulation in the spleen and lungs. Importantly, these effects became more pronounced with the increase of liposome size. Optimization of the size of the blocking liposomes holds the potential to enhance drug delivery and improve cancer therapy.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7e6f">https://doi.org/10.1088/1748-605X/ad7e6f</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7e6b" class="art-list-item-title event_main-link">Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis</a> <p class="small art-list-item-meta"> Md Ali Mujtaba <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065016 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis" data-link-purpose-append-open="Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7e6b/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis</span></a> <a href="/article/10.1088/1748-605X/ad7e6b/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Anterior uveitis is one of the most prevalent forms of ocular inflammation caused by infections, trauma, and other idiopathic conditions if not treated properly, it can cause complete blindness. Therefore, this study aimed to formulate and evaluate dexamethasone sodium phosphate (DSP) loaded polyelectrolyte complex (PEC) nanoparticles (NPs) for the treatment of anterior uveitis. DSP-loaded PEC-NPs were formed through complex coacervation by mixing low molecular weight chitosan and the anionic polymer carboxy methyl cellulose (CMC). The formulations were optimized using Box–Behnken design and evaluated the effect of independent variables: Chitosan concentration, CMC concentration, and pH of chitosan solution on the dependent variables: particle size (PS), Polydispersity Index (PDI), pH of the formulation, and % entrapment efficacy (%EE). The PS, PDI, zeta potential, and pH of the optimized formulation were found 451 ± 82.0995 nm, 0.3807 ± 0.1862, +20.33 ± 1.04 mV and 6.8367 ± 0.0737 respectively. The %EE and drug loading of formulation were 61.66 ± 4.2914% and 21.442 ± 1.814% respectively. <i>In vitro</i> drug release studies of optimized formulation showed the prolonged release up to 12 h whereas, the marketed formulation showed the burst release 85.625 ± 4.3062% in 1 h and 98.1462 ± 3.0921% at 6 h, respectively. Fourier transform infrared studies suggested the effective incorporation of the drug into the PEC-NPs formulation whereas differential scanning calorimetry and x-ray diffraction studies showed the amorphized nature of the drug in the formulation. Transmission electron microscopy study showed self-assembled, nearly spherical, core–shell nanostructures. The corneal permeation study showed higher permeation of the drug from PEC-NPs compared to the marketed formulation. Hen's Eggs test-Chorioallantoic Membrane test of the optimized formulation revealed non-irritant and safe for ocular administration. Therefore, DSP-loaded PEC-NPs are an effective substitute for conventional eye drops due to their ability to increase bioavailability through longer precorneal retention duration and sustained drug release.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7e6b">https://doi.org/10.1088/1748-605X/ad7e6b</a> </div> </div> </div> </div> </div>  </div> </div> </div>   <div tabindex="0" role="tabpanel" id="latest-articles-tab" aria-labelledby="latest-articles"> <div class=" reveal-container reveal-closed reveal-enabled reveal-container--jnl-tab"> <h2 class="tabpanel__title"> <button type="button" class="reveal-trigger event_tabs-accordion" aria-expanded="false"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg>Latest articles</button> </h2> <div class="reveal-content tabpanel__content" style="display: none"> <p> <button data-reveal-label-alt="Close all abstracts" class="reveal-all-trigger mr-2 small" data-reveal-text="Open all abstracts" data-link-purpose-append="in this tab" data-link-purpose-append-open="in this tab"> Open all abstracts<span class="offscreen-hidden">, in this tab</span> </button> </p>  <div class="art-list"> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad920e" class="art-list-item-title event_main-link">Mesalamine loaded ethyl cellulose nanoparticles: optimization and <i>in vivo</i> evaluation of antioxidant potential in ulcerative colitis</a> <p class="small art-list-item-meta"> Preety Gautam <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015008 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis" data-link-purpose-append-open="Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad920e/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis</span></a> <a href="/article/10.1088/1748-605X/ad920e/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>This study aimed to optimize mesalamine (MES)-nanoparticles (NPs) using Box Behnken Design and investigate its <i>in vivo</i> antioxidant potential in colon drug targeting. The formulation was prepared using oil/water (O/W) emulsion solvent evaporation technique for time dependent colonic delivery. The optimal formulation with the following parameters composition was selected: polymer concentration (% w/w) (A) = 0.63, surfactant concentration (% w/w) (B) = 0.71, sonication duration (min) (C) = 6. The outcomes showed that ethyl cellulose (EC) NP containing MES has particles size of 142 ± 2.8 nm, zeta potential (ZP) of −24.8 ± 2.3 mV, % EE of 87.9 ± 1.6%, and PDI of 0.226 ± 0.15. Scanning electron microscopy revealed NPs has a uniform and spherical shape. The <i>in-vitro</i> release data disclosed that the EC NPs containing MES showed bursts release of 52% ± 1.6% in simulated stomach media within 2 h, followed by a steady release of 93% ± 2.9% in simulated intestinal fluid that lasted for 48 h. The MES release from NP best match with the Korsmeyer–Peppas model (<i>R</i><sup>2</sup> = 0.962) and it followed Fickian diffusion case I release mechanism. The formulation stability over six-months at 25 °C ± 2 °C with 65% ± 5% relative humidity, and 40 °C ± 2 °C with 75% ± 5% relative humidity showed no significant changes in colour, EE, particle sizes and ZP. As per <i>in vivo</i> results, MES-NP effectively increased glutathione, SOD level and reduces the LPO level as compared to other treatment groups. The findings hold promise that the developed formulation can suitably give in ulcerative colitis.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad920e">https://doi.org/10.1088/1748-605X/ad920e</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad920f" class="art-list-item-title event_main-link">Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways</a> <p class="small art-list-item-meta"> Jiahui Chen <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015007 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways" data-link-purpose-append-open="Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad920f/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways</span></a> <a href="/article/10.1088/1748-605X/ad920f/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) on human urinary-derived stem cells (hUSCs) viability within three-dimensional (3D) cell-laden gelatin methacryloyl (GelMA) scaffolds. hUSCs were integrated into GelMA bio-inks at concentrations ranging from 2.5% to 10% w/v and then bioprinted using a volumetic-based method. Subsequent exposure of these scaffolds to LIPUS under varying parameters or sham irradiation aimed at optimizing the LIPUS treatment. Assessment of hUSCs viability employed Cell Counting Kit-8 (CCK8), cell cycle analysis, and live&dead cell double staining assays. Additionally, Western blot analysis was conducted to determine protein expression levels. With 3D bio-printed cell-laden GelMA scaffolds successfully constructed, LIPUS promoted the proliferation of hUSCs. Optimal LIPUS conditions, as determined through CCK8 and live&dead cell double staining assays, was achieved at a frequency of 1.5 MHz, a spatial-average temporal-average intensity (ISATA) of 150 mW cm<sup>−2</sup>, with an exposure duration of 10 min per session administered consecutively for two sessions. LIPUS facilitated the transition from G0/G1 phase to S and G2/M phases and enhanced the phosphorylation of ERK1/2 and PI3K-Akt. Inhibition of ERK1/2 (U0126) and PI3K (LY294002) significantly attenuated LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt respectively, both of which decreased the hUSC viability within 3D bio-printed GelMA scaffolds. Applying a LIPUS treatment at an ISATA of 150 mW cm<sup>−2</sup>promotes the growth of hUSCs within 3D bio-printed GelMA scaffolds through modulating ERK1/2 and PI3K-Akt signaling pathways.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad920f">https://doi.org/10.1088/1748-605X/ad920f</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad8c8b" class="art-list-item-title event_main-link">Lithium-containing 45S5 Bioglass-derived glass-ceramics have antioxidant activity and induce new bone formation in a rat preclinical model of type 1 diabetes mellitus</a> <p class="small art-list-item-meta"> Fátima Gomez Gramajo <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015006 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Lithium-containing 45S5 Bioglass-derived glass-ceramics have antioxidant activity and induce new bone formation in a rat preclinical model of type 1 diabetes mellitus" data-link-purpose-append-open="Lithium-containing 45S5 Bioglass-derived glass-ceramics have antioxidant activity and induce new bone formation in a rat preclinical model of type 1 diabetes mellitus">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8c8b/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Lithium-containing 45S5 Bioglass-derived glass-ceramics have antioxidant activity and induce new bone formation in a rat preclinical model of type 1 diabetes mellitus</span></a> <a href="/article/10.1088/1748-605X/ad8c8b/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Lithium-containing 45S5 Bioglass-derived glass-ceramics have antioxidant activity and induce new bone formation in a rat preclinical model of type 1 diabetes mellitus</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Diabetes mellitus (DM) has been associated with complications that affect the skeletal system, such as alterations in bone repair, osteoporosis, and an increased risk of fractures. In this context, the use of biomaterials able to promote osteogenic differentiation and, at the same time, limit the oxidative stress induced by DM offers a novel perspective to ensure the repair of diabetic bone tissue. Since lithium (Li) has been recently identified as a biologically active ion with osteogenic and antioxidant properties, the localized and controlled release of Li ions from bioactive glass-ceramic materials represents a promising therapeutic alternative for the treatment of bone lesions in DM. Thus, the aim of this study was to evaluate the potential osteogenic and antioxidant effects of glass-ceramic microparticles derived from a 45S5-type bioactive glass (Bioglass) containing (% by weight) 45% SiO<sub>2</sub>, 24.5% Na<sub>2</sub>O, 24.5% CaO, and 6% P<sub>2</sub>O<sub>5</sub>, in which Na<sub>2</sub>O was partially substituted by 5% of Li<sub>2</sub>O (45S5.5Li), in an experimental model of type 1 DM (DM1). The results obtained demonstrate, for the first time, that both 45S5 and 45S5.5Li glass-ceramic microparticles possess antioxidant activity and stimulate bone formation <i>in vivo</i> both under physiological conditions and under experimental DM1 in rats. In this sense, they would have potential application as inorganic osteogenic agents in different strategies of bone tissue regenerative medicine.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8c8b">https://doi.org/10.1088/1748-605X/ad8c8b</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad8fe8" class="art-list-item-title event_main-link">A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds</a> <p class="small art-list-item-meta"> Jay Hind Rajput <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015005 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds" data-link-purpose-append-open="A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8fe8/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds</span></a> <a href="/article/10.1088/1748-605X/ad8fe8/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Wound healing is a complex and dynamic process supported by several cellular events. Around 13 million individuals globally suffer from chronic wounds yearly, for which dressings with excellent antimicrobial activity and cell viability (>70%, as per ISO 10993) are needed. Excessive use of silver can cause cytotoxicity and has been linked to increasing antimicrobial resistance. In this study, HDI Ag foam was synthesized using a safer hexamethylene diisocyanate-based prepolymer (HDI prepolymer) instead of commonly used diisocyanates like TDI and MDI and substantially lower Ag content than that incorporated in other Ag foams. In vitro characteristics of the HDI Ag foam were evaluated in comparison with leading clinically used foam-based dressings. All dressings underwent a detailed characterization in accordance with industrially accepted BS EN 13726 standards. The HDI Ag foam exhibited highest antimicrobial efficiency against <i>S. aureus</i> and <i>P. aeruginosa</i> (static condition), with the lowest amount of Ag (0.2 wt%) on the wound contact surface. The extracts from HDI Ag foam showed superior cell viability (>70%), when tested on the L929 mouse fibroblast cell line. Measurements of moisture vapor transmission, fluid handling, physico-chemical and mechanical properties ensured that the HDI foam was clinically acceptable for chronic wound patients.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8fe8">https://doi.org/10.1088/1748-605X/ad8fe8</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad909e" class="art-list-item-title event_main-link">Fabrication of a natural nanocomposite from Syzygium cumini and squid bone waste decorated with Cu-Nps for simultaneous use in the triple method of photodynamic/photothermal/chemotherapy</a> <p class="small art-list-item-meta"> Mohsen Mehrabi <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015004 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Fabrication of a natural nanocomposite from Syzygium cumini and squid bone waste decorated with Cu-Nps for simultaneous use in the triple method of photodynamic/photothermal/chemotherapy" data-link-purpose-append-open="Fabrication of a natural nanocomposite from Syzygium cumini and squid bone waste decorated with Cu-Nps for simultaneous use in the triple method of photodynamic/photothermal/chemotherapy">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad909e/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Fabrication of a natural nanocomposite from Syzygium cumini and squid bone waste decorated with Cu-Nps for simultaneous use in the triple method of photodynamic/photothermal/chemotherapy</span></a> <a href="/article/10.1088/1748-605X/ad909e/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Fabrication of a natural nanocomposite from Syzygium cumini and squid bone waste decorated with Cu-Nps for simultaneous use in the triple method of photodynamic/photothermal/chemotherapy</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>This work reports a new nano platform made from natural materials for phototherapy (PT) applications. For this purpose, calcium carbonate nanoparticles (NPs) derived from Persian Gulf squid bones as a drug carrier, Syzygium cumini (dye extracted from the fruit of the Persian Gulf trees) as a photosensitizer, and Doxorubicin as a chemotherapy (CHT) drug have been used. In addition, copper NPs were added to the above nanocomposition to increase the efficiency of photothermal (PTT) treatment. For PT, samples were irradiated by an 808 nm laser (1 W cm<sup>−2</sup>). The results show that nanocomposites play an influential role in the reactive oxygen species process, and an increase of 21 degrees in temperature during 15 min of laser radiation is effective in photodynamic (PDT)/PTT therapy. The drug loading capacity of the nanocomposite was calculated as 49%. This new nanocomposite for simultaneous PDT/PTT/CHT holds great promise for future cancer treatment due to its excellent potential in treatment and reduced systemic toxicity.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad909e">https://doi.org/10.1088/1748-605X/ad909e</a> </div> </div> </div> </div> </div>  </div> </div> </div>     <div tabindex="0" role="tabpanel" id="review-articles-tab" aria-labelledby="review-articles" hidden="hidden"> <div class=" reveal-container reveal-closed reveal-enabled reveal-container--jnl-tab"> <h2 class="tabpanel__title"> <button type="button" class="reveal-trigger event_tabs-accordion" aria-expanded="false"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg>Review articles</button> </h2> <div class="reveal-content tabpanel__content" style="display: none"> <p> <button data-reveal-label-alt="Close all abstracts" class="reveal-all-trigger mr-2 small" data-reveal-text="Open all abstracts" data-link-purpose-append="in this tab" data-link-purpose-append-open="in this tab"> Open all abstracts<span class="offscreen-hidden">, in this tab</span> </button> </p>  <div class="art-list"> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad8541" class="art-list-item-title event_main-link">Polylysine in biomedical applications: from composites to breakthroughs</a> <p class="small art-list-item-meta"> A Deepak <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 062002 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Polylysine in biomedical applications: from composites to breakthroughs" data-link-purpose-append-open="Polylysine in biomedical applications: from composites to breakthroughs">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8541/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Polylysine in biomedical applications: from composites to breakthroughs</span></a> <a href="/article/10.1088/1748-605X/ad8541/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Polylysine in biomedical applications: from composites to breakthroughs</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Polylysine-based composites have emerged as promising materials in biomedical applications due to their versatility, biocompatibility, and tunable properties. In drug delivery, polylysine-based composites furnish a novel platform for targeted and controlled release of therapeutic agents. Their high loading capacity and capability to encapsulate diverse drugs make them ideal candidates for addressing challenges such as drug stability and controlled release kinetics. Additionally, their biocompatibility ensures minimal cytotoxicity, which is vital for biomedical applications. They also hold substantial potential in tissue engineering by providing a scaffold with tunable mechanical characteristics and surface properties and can support cell adhesion, proliferation, and differentiation. Furthermore, their bioactive nature facilitates cellular interactions, promoting tissue regeneration and integration. Wound healing is another area where polylysine-based composites show promise. Their antimicrobial properties help prevent infections, while their ability to foster cell migration and proliferation accelerates the wound healing procedure. Incorporation of growth factors or other bioactive molecules further enhances their therapeutic effectiveness. In biosensing applications, they serve as robust substrates for immobilizing biomolecules and sensing elements. Their high surface area-to-volume ratio and excellent biocompatibility improve sensor sensitivity and selectivity, enabling accurate detection of biomarkers or analytes in biological samples. Polylysine-based composites offer potential as contrast agents in bioimaging, aiding in the diagnosis and monitoring of diseases. Overall, polylysine-based composites represent a versatile platform with diverse applications in biomedical research and clinical practice, holding great promise for addressing various healthcare challenges.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8541">https://doi.org/10.1088/1748-605X/ad8541</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad7c0c" class="art-list-item-title event_main-link">Bioengineered larynx and vocal folds: where are we today? A review</a> <p class="small art-list-item-meta"> Reza Kaboodkhani <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 062001 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Bioengineered larynx and vocal folds: where are we today? A review" data-link-purpose-append-open="Bioengineered larynx and vocal folds: where are we today? A review">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7c0c/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Bioengineered larynx and vocal folds: where are we today? A review</span></a> <a href="/article/10.1088/1748-605X/ad7c0c/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Bioengineered larynx and vocal folds: where are we today? A review</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The larynx is responsible for breathing, producing sound, and protecting the trachea against food aspiration through the cough reflex. Nowadays, scaffolding surgery has made it easier to regenerate damaged tissues by facilitating the influx of cells and growth factors. This review provides a comprehensive overview of the current knowledge on tissue engineering of the larynx and vocal folds. It also discusses the achievements and challenges of data sources. In conducting a literature search for relevant papers, we included 68 studies from January 2000 to November 2023, sourced from PubMed and Scholar Google databases. We found a need for collaboration between voice care practitioners, voice scientists, bioengineers, chemists, and biotechnologists to develop safe and clinically valid solutions for patients with laryngeal and vocal fold injuries. It is crucial for patients to be knowledgeable about the available choices of laryngeal tissue engineering for successful tissue repair. Although few human trials have been conducted, future works should build upon previously completed <i>in-vivo</i> studies in an effort to move towards more human models.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7c0c">https://doi.org/10.1088/1748-605X/ad7c0c</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad6dc7" class="art-list-item-title event_main-link">Curcumin nanopreparations: recent advance in preparation and application</a> <p class="small art-list-item-meta"> Yan Liu <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 052009 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Curcumin nanopreparations: recent advance in preparation and application" data-link-purpose-append-open="Curcumin nanopreparations: recent advance in preparation and application">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad6dc7/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Curcumin nanopreparations: recent advance in preparation and application</span></a> <a href="/article/10.1088/1748-605X/ad6dc7/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Curcumin nanopreparations: recent advance in preparation and application</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Curcumin is a natural polyphenolic compound extracted from turmeric with antibacterial, antioxidant, antitumor, preventive and therapeutic neurological disorders and a variety of bioactivities, which is widely used in the field of food and medicine. However, the drawbacks of curcumin such as poor aqueous solubility and stability have limited the practical application of curcumin. To overcome these defects and enhance its functional properties, various nanoscale systems (liposomes, polymer nanoparticles, protein nanoparticles, solid lipid nanoparticles, metal nanoparticles, etc) have been extensively employed for curcumin encapsulation and delivery. Despite the rapid development of curcumin nanoformulations, there is a lack of comprehensive reviews on their preparation and properties. This review provides an overview of the construction of curcumin nano-delivery systems, mechanisms of action, nanocarrier preparation methods and the applications of curcumin nanocarriers in the food and pharmaceutical fields to provide a theoretical basis and technological support for the efficient bio-utilization, product development and early clinical application of curcumin.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad6dc7">https://doi.org/10.1088/1748-605X/ad6dc7</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad651d" class="art-list-item-title event_main-link">Advancements in stimulation therapies for peripheral nerve regeneration</a> <p class="small art-list-item-meta"> Rosalie Bordett <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 052008 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Advancements in stimulation therapies for peripheral nerve regeneration" data-link-purpose-append-open="Advancements in stimulation therapies for peripheral nerve regeneration">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad651d/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Advancements in stimulation therapies for peripheral nerve regeneration</span></a> <a href="/article/10.1088/1748-605X/ad651d/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Advancements in stimulation therapies for peripheral nerve regeneration</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Soft-tissue injuries affecting muscles, nerves, vasculature, tendons, and ligaments often diminish the quality of life due to pain, loss of function, and financial burdens. Both natural healing and surgical interventions can result in scarring, which potentially may impede functional recovery and lead to persistent pain. Scar tissue, characterized by a highly disorganized fibrotic extracellular matrix, may serve as a physical barrier to regeneration and drug delivery. While approaches such as drugs, biomaterials, cells, external stimulation, and other physical forces show promise in mitigating scarring and promoting regenerative healing, their implementation remains limited and challenging. Ultrasound, laser, electrical, and magnetic forms of external stimulation have been utilized to promote soft tissue as well as neural tissue regeneration. After stimulation, neural tissues experience increased proliferation of Schwann cells, secretion of neurotropic factors, production of myelin, and growth of vasculature, all aimed at supporting axon regeneration and innervation. Yet, the outcomes of healing vary depending on the pathophysiology of the damaged nerve, the timing of stimulation following injury, and the specific parameters of stimulation employed. Increased treatment intensity and duration have been noted to hinder the healing process by inducing tissue damage. These stimulation modalities, either alone or in combination with nerve guidance conduits and scaffolds, have been demonstrated to promote healing. However, the literature currently lacks a detailed understanding of the stimulation parameters used for nerve healing applications. In this article, we aim to address this gap by summarizing existing reports and providing an overview of stimulation parameters alongside their associated healing outcomes.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad651d">https://doi.org/10.1088/1748-605X/ad651d</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad6dc3" class="art-list-item-title event_main-link">Nano-mediated strategy: recent advance in the application of drug delivery systems in melanoma treatment and diagnosis</a> <p class="small art-list-item-meta"> Yinan Wang <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 052007 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Nano-mediated strategy: recent advance in the application of drug delivery systems in melanoma treatment and diagnosis" data-link-purpose-append-open="Nano-mediated strategy: recent advance in the application of drug delivery systems in melanoma treatment and diagnosis">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad6dc3/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Nano-mediated strategy: recent advance in the application of drug delivery systems in melanoma treatment and diagnosis</span></a> <a href="/article/10.1088/1748-605X/ad6dc3/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Nano-mediated strategy: recent advance in the application of drug delivery systems in melanoma treatment and diagnosis</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Melanoma is a common malignant tumor, with a five-year mortality rate as high as 62% in cases of metastatic melanoma according to cancer statistics (2024). In recent years, the focus of melanoma research has predominantly centered on immunotherapy and targeted therapy, grappling with challenges such as resistance and immunogenicity. The discovery of nanoparticles (NPs) has brought nano-delivery systems to the forefront of melanoma diagnosis and treatment. Although certain NPs, like liposomes, have gained clinical approval, utilizing most nano-delivery systems for melanoma diagnosis and treatment remains largely exploratory. The inherent limitations of NPs present a major obstacle to their clinical translation. By selecting suitable nanocarriers and functionalizing NPs to optimize nano-delivery systems, and combining these systems with other therapies, it is possible to reduce the systemic toxicity and resistance associated with conventional therapies and the NPs themselves. This optimization could significantly improve the effectiveness of nano-delivery systems in the early detection and timely treatment of melanoma. However, there have been few reviews on the optimization of NPs and the combined application of other therapies in the treatment and diagnostic application of melanoma in the past three years. This review summarizes the latest applications of nano-delivery systems in the diagnosis and treatment of melanoma over the past three years, including innovations and achievements in both preclinical and clinical studies, offering new perspectives on their potential and future application prospects. It integrates clinical data and patent information, highlights trends in nano-delivery system development, and offers new insights into their clinical translation. Additionally, it discusses the challenges and opportunities of nano-delivery systems in melanoma treatment, providing a foundation for advancing their application in diagnosis, treatment, and clinical translation.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad6dc3">https://doi.org/10.1088/1748-605X/ad6dc3</a> </div> </div> </div> </div> </div>  </div> </div> </div>       <div tabindex="0" role="tabpanel" id="accepted-manuscripts-tab" aria-labelledby="accepted-manuscripts" hidden="hidden"> <div class="reveal-container reveal-closed reveal-enabled reveal-container--jnl-tab"> <h2 class="tabpanel__title"> <button type="button" class="reveal-trigger event_tabs-accordion" aria-expanded="false"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg>Accepted manuscripts</button> </h2> <div class="reveal-content tabpanel__content" style="display: none;">  <p id="jnl-issue-disp-links" class="cf"> <button data-reveal-label-alt="Close all abstracts" class="reveal-all-trigger mr-2 small" data-reveal-text="Open all abstracts" data-link-purpose-append="in this tab" data-link-purpose-append-open="in this tab">Open all abstracts<span class="offscreen-hidden">, in this tab</span></button> </p>  <div class="art-list" id="wd-jnl-issue-art-list"> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad95d3" class="art-list-item-title event_main-link">Development of triple-helical recombinant collagen-silver hybrid nanofibers for anti-methicillin-resistant Staphylococcus aureus (MRSA) applications</a> <p class="small art-list-item-meta"> Fu et al  </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Development of triple-helical recombinant collagen-silver hybrid nanofibers for anti-methicillin-resistant Staphylococcus aureus (MRSA) applications" data-link-purpose-append-open="Development of triple-helical recombinant collagen-silver hybrid nanofibers for anti-methicillin-resistant Staphylococcus aureus (MRSA) applications">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad95d3/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View accepted manuscript<span class="offscreen-hidden">, Development of triple-helical recombinant collagen-silver hybrid nanofibers for anti-methicillin-resistant Staphylococcus aureus (MRSA) applications</span></a> <a href="/article/10.1088/1748-605X/ad95d3/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Development of triple-helical recombinant collagen-silver hybrid nanofibers for anti-methicillin-resistant Staphylococcus aureus (MRSA) applications</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"> <p>The escalating threat of healthcare-associated infections highlights the urgent need for biocompatible antibacterial materials that effectively combat drug-resistant pathogens. In this study, we present a novel fabrication method for triple-helical recombinant collagen-silver hybrid nanofibers, specifically designed for anti-Methicillin-Resistant Staphylococcus aureus (MRSA) applications. Utilizing a silver-mediated crosslinking strategy, we harness a low-power 38 W lamp to enable silver ions (Ag+) to mediate crosslinking across various proteins. Mechanistic insights reveal the pivotal role of nine amino acids in facilitating this reaction. The triple-helical recombinant collagen (THRC) maintains its native structure, forming well-ordered nanofibers, while other globular proteins form a distinctive network-like structure. THRC also serves as a reducing and dispersing agent, facilitating the in situ synthesis of highly dispersed silver nanoparticles (AgNPs) (~7 nm in diameter) within the nanofibers. Systematic investigation of the reaction conditions between THRC and Ag+ demonstrates the versatility of this novel approach for nanofiber fabrication. The incorporation of AgNPs imparts exceptional antibacterial activity to the THRC/AgNPs nanofibers, exhibiting a minimum inhibitory concentration (MIC) of 19.2 mg/L and a minimum bactericidal concentration (MBC) of 153.6 mg/L against MRSA. This innovative approach holds significant potential for developing antibacterial protein-based biomaterials for infection management in wound healing and other biomedical applications.&#xD;&#xD;&#xD;</p> </div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad95d3">https://doi.org/10.1088/1748-605X/ad95d3</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad920d" class="art-list-item-title event_main-link">Prevention of early thrombosis in transplanted vein model by encapsulation with tirofiban microneedle drug delivery system</a> <p class="small art-list-item-meta"> Wang et al  </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Prevention of early thrombosis in transplanted vein model by encapsulation with tirofiban microneedle drug delivery system" data-link-purpose-append-open="Prevention of early thrombosis in transplanted vein model by encapsulation with tirofiban microneedle drug delivery system">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad920d/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View accepted manuscript<span class="offscreen-hidden">, Prevention of early thrombosis in transplanted vein model by encapsulation with tirofiban microneedle drug delivery system</span></a> <a href="/article/10.1088/1748-605X/ad920d/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Prevention of early thrombosis in transplanted vein model by encapsulation with tirofiban microneedle drug delivery system</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"> <p>Early thrombosis following CABG surgery leads to perioperative myocardial infarction, which causes difficulties for clinicians and patients. Moreover, once perioperative myocardial infarction occurs, the mortality rate is extremely high. In recent years, microneedle (MN) drug delivery systems have become a research hotspot with broad clinical application prospects. These systems are capable of achieving sustained, safe, and painless local drug release. In cardiovascular applications, MNs maximize local anticoagulant effects, inhibit endometrial hyperplasia, and reduce systemic side effects. We speculate that a MN drug delivery system can be used to target transplanted veins to inhibit their thrombosis and reduce the incidence of perioperative myocardial infarction after CABG surgery. Therefore, this study developed a hyaluronic acid MN patch loaded with tirofiban and conducted preliminary physicochemical tests. The safety, efficacy, biocompatibility, and targeting of the MN system were evaluated using in vitro and in vivo experiments using a jugular vein transplantation model. The results indicate that the MN system has excellent physical properties, safety, effectiveness, biocompatibility, and strong targeting, which can effectively inhibit early local thrombus formation. In addition, the observation of early postoperative endometrial hyperplasia activation provides a foundation for future research.&#xD;</p> </div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad920d">https://doi.org/10.1088/1748-605X/ad920d</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad906b" class="art-list-item-title event_main-link">Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms</a> <p class="small art-list-item-meta"> Mujtaba et al  </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms" data-link-purpose-append-open="Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad906b/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View accepted manuscript<span class="offscreen-hidden">, Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms</span></a> <a href="/article/10.1088/1748-605X/ad906b/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"> <p>The rise of antimicrobial resistance necessitates innovative strategies to combat persistent infections. Metal-Organic Frameworks (MOFs) have attracted significant attention as antibiotic carriers due to their high drug loading capacity and structural adaptability. In particular, 2D MOF nanosheets are emerging as a notable alternative to their traditional 3D relatives due to their remarkable advantages in enhanced surface area, flexibility and exposed active region properties. Herein, we synthesized 2D Copper 1,4-benzendicarboxylate (CuBDC) nanosheets and utilized them as a carrier and controlled release system for Doxycycline (Doxy@CuBDC), for the first time. The Doxy@CuBDC nanosheets were subsequently incorporated into poly (DL-lactide-co-glycolide) (PLGA) electrospun membranes (Doxy@CuBDC/PLGA). The resultant bioactive fibrous membranes exhibited double-barrier controlled release properties, extending the Doxy release up to ∼9 days at pH 7.4 and 5.5. Significant inhibitory effects against Staphylococcus aureus and Escherichia coli were observed. The morphological analyses revealed the deformed bacterial cell structures on Doxy@CuBDC/PLGA membranes that indicates potent bactericidal activity. Furthermore, cytotoxicity assays demonstrated the non-toxic nature of the fabricated membranes, underscoring their potential use for biomedical applications. Overall, the hybrid antibacterial PLGA membranes present a promising strategy for combating microbial infections while maintaining biocompatibility and offer a versatile approach for biomedical material design and surface coatings (e.g., wound dressings, implants).&#xD;</p> </div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad906b">https://doi.org/10.1088/1748-605X/ad906b</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <a href="/article/10.1088/1748-605X/ad8f80" class="art-list-item-title event_main-link">4D printing of smart scaffolds for bone regeneration: a systematic review</a> <p class="small art-list-item-meta"> Gharehdaghi et al  </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="4D printing of smart scaffolds for bone regeneration: a systematic review" data-link-purpose-append-open="4D printing of smart scaffolds for bone regeneration: a systematic review">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8f80/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View accepted manuscript<span class="offscreen-hidden">, 4D printing of smart scaffolds for bone regeneration: a systematic review</span></a> <a href="/article/10.1088/1748-605X/ad8f80/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, 4D printing of smart scaffolds for bone regeneration: a systematic review</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"> <p>Objective:&#xD;As a novel emerging technology, four-dimensional (4D) printing allows 3D-printed materials to change over time. This systematic review is conducted to evaluate the purpose, materials, physiomechanical, and biological properties of 4D-printed scaffolds used for bone tissue engineering.&#xD;Method and materials:&#xD;An electronic search was conducted following the PRISMA 2020 guidelines in PubMed, Scopus, Web of Science, and Google Scholar online databases limited to English articles until April 2024. Studies in which scaffolds were fabricated through 3D printing methods responding to external stimulation were included. The quality of in vitro and in vivo studies was evaluated through the modified CONSORT checklist and SYRCLE's risk of bias tool.&#xD;Results:&#xD;The full text of 57 studies were reviewed, and 15 studies met the inclusion criteria. According to the analyzed studies, most scaffolds responded to temperature changes showing shape memory effect. Polyurethane (PU) and poly(lactic acid) (PLA) were the most common shape memory polymers, and the most common fabrication method used was Fused Deposition Modeling (FDM).&#xD;Conclusion:&#xD;A comprehensive systematic review of the studies from the past 10 years demonstrated several findings: 1) Shape memory, drug delivery, and shape morphing are three general purposes of 4D printing for bone regeneration. 2) Smart materials used for 4D printing mostly consist of shape memory polymers. 3) Temperature changes account for the majority of stimulation used for 4D printing. 4) incorporating 4D printing principles does not have a negative impact on the physiomechanical properties of the designed scaffold. 5) The 4D-printed scaffolds show a higher osteogenic differentiation capacity than their identical 3D-printed structures in terms of bone regeneration.&#xD;</p> </div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8f80">https://doi.org/10.1088/1748-605X/ad8f80</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7561" class="art-list-item-title event_main-link">Influence of different pressure regimes on the properties of an engineered small-diameter vascular scaffold tested in a custom-made bioreactor</a> <p class="small art-list-item-meta"> Ferrari et al  </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Influence of different pressure regimes on the properties of an engineered small-diameter vascular scaffold tested in a custom-made bioreactor" data-link-purpose-append-open="Influence of different pressure regimes on the properties of an engineered small-diameter vascular scaffold tested in a custom-made bioreactor">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7561/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View accepted manuscript<span class="offscreen-hidden">, Influence of different pressure regimes on the properties of an engineered small-diameter vascular scaffold tested in a custom-made bioreactor</span></a> <a href="/article/10.1088/1748-605X/ad7561/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Influence of different pressure regimes on the properties of an engineered small-diameter vascular scaffold tested in a custom-made bioreactor</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"> <p>Vascular tissue engineering endeavors to design, fabricate, and validate biodegradable and bioabsorbable small-diameter vascular scaffolds engineered with bioactive molecules, capable of meeting the challenges imposed by commercial vascular prostheses. A comprehensive investigation of these engineered scaffolds in bioreactor is deemed essential as a prerequisite before any in vivo experimentation in order to get information regarding their behavior under physiological conditions and predict the biological activities they will possess. This study focuses on an innovative electrospun scaffold made of poly(caprolactone) and poly(glycerol sebacate), integrating quercetin, able to modulate inflammation, and gelatin, necessary to reduce permeability. A custom-made bioreactor was used to assess the performances of the scaffolds maintained under different pressure regimes, covering the human physiological pressure range. As results, the 3D microfibrous architecture was notably influenced by the release of bioactives, maintaining the adequate properties needed for the in vivo regeneration and scaffolds showed mechanical properties similar to human native artery. Release of gelatin was adequate to avoid blood leakage and useful to make the material porous during the testing period, whereas the amount of released quercetin was useful to counteract the post-surgery inflammation. This study showcases the successful validation of an engineered scaffold in a bioreactor, enabling to consider it as a promising candidate for vascular substitutes in in vivo applications. Our approach represents a significant leap forward in the field of vascular tissue engineering, offering a multifaceted solution to the complex challenges associated with small-diameter vascular prostheses.&#xD;</p> </div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7561">https://doi.org/10.1088/1748-605X/ad7561</a> </div> </div> </div> </div> </div>  <p> <a href="/journal/1748-605X/acceptedmanuscripts/1">More Accepted manuscripts</a> </p>  </div> </div> </div>     <div tabindex="0" role="tabpanel" id="open-access-articles-tab" aria-labelledby="open-access-articles" hidden="hidden"> <div class=" reveal-container reveal-closed reveal-enabled reveal-container--jnl-tab"> <h2 class="tabpanel__title"> <button type="button" class="reveal-trigger event_tabs-accordion" aria-expanded="false"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg>Open access</button> </h2> <div class="reveal-content tabpanel__content" style="display: none"> <p> <button data-reveal-label-alt="Close all abstracts" class="reveal-all-trigger mr-2 small" data-reveal-text="Open all abstracts" data-link-purpose-append="in this tab" data-link-purpose-append-open="in this tab"> Open all abstracts<span class="offscreen-hidden">, in this tab</span> </button> </p>  <div class="art-list"> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad920e" class="art-list-item-title event_main-link">Mesalamine loaded ethyl cellulose nanoparticles: optimization and <i>in vivo</i> evaluation of antioxidant potential in ulcerative colitis</a> <p class="small art-list-item-meta"> Preety Gautam <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015008 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis" data-link-purpose-append-open="Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad920e/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis</span></a> <a href="/article/10.1088/1748-605X/ad920e/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>This study aimed to optimize mesalamine (MES)-nanoparticles (NPs) using Box Behnken Design and investigate its <i>in vivo</i> antioxidant potential in colon drug targeting. The formulation was prepared using oil/water (O/W) emulsion solvent evaporation technique for time dependent colonic delivery. The optimal formulation with the following parameters composition was selected: polymer concentration (% w/w) (A) = 0.63, surfactant concentration (% w/w) (B) = 0.71, sonication duration (min) (C) = 6. The outcomes showed that ethyl cellulose (EC) NP containing MES has particles size of 142 ± 2.8 nm, zeta potential (ZP) of −24.8 ± 2.3 mV, % EE of 87.9 ± 1.6%, and PDI of 0.226 ± 0.15. Scanning electron microscopy revealed NPs has a uniform and spherical shape. The <i>in-vitro</i> release data disclosed that the EC NPs containing MES showed bursts release of 52% ± 1.6% in simulated stomach media within 2 h, followed by a steady release of 93% ± 2.9% in simulated intestinal fluid that lasted for 48 h. The MES release from NP best match with the Korsmeyer–Peppas model (<i>R</i><sup>2</sup> = 0.962) and it followed Fickian diffusion case I release mechanism. The formulation stability over six-months at 25 °C ± 2 °C with 65% ± 5% relative humidity, and 40 °C ± 2 °C with 75% ± 5% relative humidity showed no significant changes in colour, EE, particle sizes and ZP. As per <i>in vivo</i> results, MES-NP effectively increased glutathione, SOD level and reduces the LPO level as compared to other treatment groups. The findings hold promise that the developed formulation can suitably give in ulcerative colitis.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad920e">https://doi.org/10.1088/1748-605X/ad920e</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad920f" class="art-list-item-title event_main-link">Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways</a> <p class="small art-list-item-meta"> Jiahui Chen <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015007 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways" data-link-purpose-append-open="Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad920f/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways</span></a> <a href="/article/10.1088/1748-605X/ad920f/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) on human urinary-derived stem cells (hUSCs) viability within three-dimensional (3D) cell-laden gelatin methacryloyl (GelMA) scaffolds. hUSCs were integrated into GelMA bio-inks at concentrations ranging from 2.5% to 10% w/v and then bioprinted using a volumetic-based method. Subsequent exposure of these scaffolds to LIPUS under varying parameters or sham irradiation aimed at optimizing the LIPUS treatment. Assessment of hUSCs viability employed Cell Counting Kit-8 (CCK8), cell cycle analysis, and live&dead cell double staining assays. Additionally, Western blot analysis was conducted to determine protein expression levels. With 3D bio-printed cell-laden GelMA scaffolds successfully constructed, LIPUS promoted the proliferation of hUSCs. Optimal LIPUS conditions, as determined through CCK8 and live&dead cell double staining assays, was achieved at a frequency of 1.5 MHz, a spatial-average temporal-average intensity (ISATA) of 150 mW cm<sup>−2</sup>, with an exposure duration of 10 min per session administered consecutively for two sessions. LIPUS facilitated the transition from G0/G1 phase to S and G2/M phases and enhanced the phosphorylation of ERK1/2 and PI3K-Akt. Inhibition of ERK1/2 (U0126) and PI3K (LY294002) significantly attenuated LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt respectively, both of which decreased the hUSC viability within 3D bio-printed GelMA scaffolds. Applying a LIPUS treatment at an ISATA of 150 mW cm<sup>−2</sup>promotes the growth of hUSCs within 3D bio-printed GelMA scaffolds through modulating ERK1/2 and PI3K-Akt signaling pathways.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad920f">https://doi.org/10.1088/1748-605X/ad920f</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad8c8a" class="art-list-item-title event_main-link">Assessing cytotoxicity: a comparative analysis of biodegradable and conventional 3D-printing materials post-steam sterilization for surgical guides</a> <p class="small art-list-item-meta"> Matthias W Gielisch <em>et al</em> 2025 <em>Biomed. Mater.</em> <b>20</b> 015001 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Assessing cytotoxicity: a comparative analysis of biodegradable and conventional 3D-printing materials post-steam sterilization for surgical guides" data-link-purpose-append-open="Assessing cytotoxicity: a comparative analysis of biodegradable and conventional 3D-printing materials post-steam sterilization for surgical guides">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8c8a/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Assessing cytotoxicity: a comparative analysis of biodegradable and conventional 3D-printing materials post-steam sterilization for surgical guides</span></a> <a href="/article/10.1088/1748-605X/ad8c8a/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Assessing cytotoxicity: a comparative analysis of biodegradable and conventional 3D-printing materials post-steam sterilization for surgical guides</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p><i>Introduction.</i> Ecological concerns and the depletion of petroleum resources have driven the exploration of biodegradable 3D-printing materials derived from bio-renewable sources, such as polylactic acid (PLA) and polyhydroxyalkanoates (PHA). This study aimed to compare the potential cytotoxic effects of a biodegradable PLA/PHA blend filament, a conventional photopolymer (MED610), and a combination of MED610 with a support material (SUP705) before and after steam sterilization in vitro, with a focus on their application in the production of surgical guides. <i>Materials and Methods.</i> PLA/PHA, MED610, and SUP705 (both in their pure and steam-sterilized forms; <i>n</i> = 6 per group) were assessed for their cytotoxic effects on human fibroblasts using the neutral red uptake assay. Positive controls included zinc diethyldithiocarbamate and zinc dibutyldithiocarbamate, while high-density polyethylene served as a negative control. A stock solution of the extraction medium was used as the vehicle control (VC). <i>Results.</i> Significant differences in cell viability were observed between pure PLA/PHA (1.2 ± 0.24) and MED610 (0.94 ± 0.08) (<i>p</i> = 0.005). However, both materials exhibited non-cytotoxicity, with cell viability exceeding 70% compared to VCs. SUP705 (0.58 ± 0.42) demonstrated significantly reduced cell viability compared to PLA/PHA (<i>p</i> = 0.001) and MED610 (<i>p</i> = 0.007). After steam sterilization, no significant difference in cell viability was noted between MED610 (1.0 ± 0.08) and PLA/PHA (1.2 ± 0.25) (<i>p</i> = 0.111). While both materials remained non-cytotoxic after sterilization, SUP705 (0.60 ± 0.45) exhibited cytotoxic effects compared to MED610 (<i>p</i> = 0.006) and PLA/PHA (<i>p</i> < 0.001). Steam sterilization did not induce significant cytotoxic effects in the investigated materials (<i>p</i> = 0.123). <i>Conclusion.</i> Pure and steam-sterilized PLA/PHA and MED610 were not cytotoxic, supporting their potential use in the production of surgical guides. However, the observed cytotoxicity of SUP705 suggests caution in scenarios requiring sterile conditions, as the removal of support material from complex printed parts may be challenging. The consideration of PLA/PHA is recommended in such settings to ensure biocompatibility.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8c8a">https://doi.org/10.1088/1748-605X/ad8c8a</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad906b" class="art-list-item-title event_main-link">Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms</a> <p class="small art-list-item-meta"> Ayse Gunyakti Mujtaba <em>et al</em> 2024 <em>Biomed. Mater.</em> <b></b> </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms" data-link-purpose-append-open="Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad906b/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms</span></a> <a href="/article/10.1088/1748-605X/ad906b/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Hybrid poly(lactide-co-glycolide) membranes incorporated with doxycycline-loaded copper-based metal-organic nanosheets as antibacterial platforms</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The rise of antimicrobial resistance necessitates innovative strategies to combat persistent infections. Metal-Organic Frameworks (MOFs) have attracted significant attention as antibiotic carriers due to their high drug loading capacity and structural adaptability. In particular, 2D MOF nanosheets are emerging as a notable alternative to their traditional 3D relatives due to their remarkable advantages in enhanced surface area, flexibility and exposed active region properties. Herein, we synthesized 2D Copper 1,4-benzendicarboxylate (CuBDC) nanosheets and utilized them as a carrier and controlled release system for Doxycycline (Doxy@CuBDC), for the first time. The Doxy@CuBDC nanosheets were subsequently incorporated into poly (DL-lactide-co-glycolide) (PLGA) electrospun membranes (Doxy@CuBDC/PLGA). The resultant bioactive fibrous membranes exhibited double-barrier controlled release properties, extending the Doxy release up to ∼9 days at pH 7.4 and 5.5. Significant inhibitory effects against Staphylococcus aureus and Escherichia coli were observed. The morphological analyses revealed the deformed bacterial cell structures on Doxy@CuBDC/PLGA membranes that indicates potent bactericidal activity. Furthermore, cytotoxicity assays demonstrated the non-toxic nature of the fabricated membranes, underscoring their potential use for biomedical applications. Overall, the hybrid antibacterial PLGA membranes present a promising strategy for combating microbial infections while maintaining biocompatibility and offer a versatile approach for biomedical material design and surface coatings (e.g., wound dressings, implants).&#xD;</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad906b">https://doi.org/10.1088/1748-605X/ad906b</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad8828" class="art-list-item-title event_main-link">Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture</a> <p class="small art-list-item-meta"> Ruya Zhang <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065036 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture" data-link-purpose-append-open="Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad8828/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture</span></a> <a href="/article/10.1088/1748-605X/ad8828/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>The mechanical competence and suturing ability of collagen-based membranes are paramount in guided bone regeneration (GBR) therapy, to ensure damage-free implantation, fixation and space maintenance <i>in vivo</i>. However, contact with the biological medium can induce swelling of collagen molecules, yielding risks of membrane sinking into the bone defect, early loss of barrier function, and irreversibly compromised clinical outcomes. To address these challenges, this study investigates the effect of the crosslinked network architecture on both mechanical and suture-holding properties of a new atelocollagen (AC) membrane. UV-cured networks were obtained via either single functionalisation of AC with 4-vinylbenzyl chloride (4VBC) or sequential functionalisation of AC with both 4VBC and methacrylic anhydride. The wet-state compression modulus (<i>E</i><sub>c</sub>) and swelling ratio (SR) were significantly affected by the UV-cured network architecture, leading up to a three-fold reduction in SR and about two-fold increase in <i>E</i><sub>c</sub> in the sequentially functionalised, compared to the single-functionalised, samples. Electron microscopy, dimensional analysis and compression testing revealed the direct impact of the ethanol series dehydration process on membrane microstructure, yielding densification of the freshly synthesised porous samples and a pore-free microstructure with increased <i>E</i><sub>c</sub>. Nanoindentation tests via spherical bead-probe atomic force microscopy (AFM) confirmed an approximately two-fold increase in median (interquartile range (IQR)) elastic modulus in the sequentially functionalised (<i>E</i><sub>AFM</sub> = 40 (13) kPa), with respect to single-functionalised (<i>E</i><sub>AFM</sub> = 15 (9) kPa), variants. Noteworthy, the single-functionalised, but not the sequentially functionalised, samples displayed higher suture retention strength (SRS = 28 ± 2–35 ± 10 N<img src="https://cdn.images.iop.org/Entities/bdot.gif" alt="bold dot" align="absmiddle" />mm<sup>−1</sup>) in both the dry state and following 1 h in phosphate buffered saline (PBS), compared to Bio-Gide® (SRS: 6 ± 1–14 ± 2 N<img src="https://cdn.images.iop.org/Entities/bdot.gif" alt="bold dot" align="absmiddle" />mm<sup>−1</sup>), while a significant decrease was measured after 24 h in PBS (SRS= 1 ± 1 N<img src="https://cdn.images.iop.org/Entities/bdot.gif" alt="bold dot" align="absmiddle" />mm<sup>−1</sup>). These structure-property relationships confirm the key role played by the molecular architecture of covalently crosslinked collagen, aimed towards long-lasting resorbable membranes for predictable GBR therapy.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad8828">https://doi.org/10.1088/1748-605X/ad8828</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad82c6" class="art-list-item-title event_main-link">Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels</a> <p class="small art-list-item-meta"> Charles de Kergariou <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065026 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels" data-link-purpose-append-open="Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad82c6/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels</span></a> <a href="/article/10.1088/1748-605X/ad82c6/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Generalisation of the yield stress measurement in three point bending collapse tests: application to 3D printed flax fibre reinforced hydrogels</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>This paper describes the extrusion pressure's effect on composite hydrogel inks' filaments subjected to three point bending collapse tests. The composite considered in this work consists of an alginate-poloxamer hydrogel reinforced with flax fibres. Increased extrusion pressure resulted in more asymmetrical filaments between the support pillars. Furthermore, the material and printing conditions used in the present study led to the production of curved specimens. These two characteristics implicitly limit the validity of the yield stress equations commonly used in open literature. Therefore, a new system of equations was derived for the case of asymmetrical and curved filaments. A post-processing method was also created to obtain the properties required to evaluate this yield stress. This new equation was then implemented to identify the strength of failed hydrogels without flax fibre reinforcement. A statistical analysis showed this new equation's significance, which yielded statistically higher (i.e. 1.15 times larger) strength values compared to the numbers obtained with the open literature equations. At larger extrusion pressures, longer periods were needed for the material to converge towards its final shape. Larger extrusion pressure values led to lower yield stresses within the composite hydrogel filament: a 5 kPa increase in extrusion pressure lowered the yield stress by 19%. In comparison, a 15 kPa increase led to a 29% decrease in the yield stress. Overall this study provides guidelines to standardize three point bending collapse tests and analysis comparison between different materials.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad82c6">https://doi.org/10.1088/1748-605X/ad82c6</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7e6f" class="art-list-item-title event_main-link">MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner</a> <p class="small art-list-item-meta"> Iaroslav B Belyaev <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065022 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner" data-link-purpose-append-open="MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7e6f/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner</span></a> <a href="/article/10.1088/1748-605X/ad7e6f/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, MPS blockade with liposomes controls pharmacokinetics of nanoparticles in a size-dependent manner</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Pharmacokinetics of nanomedicines can be improved by a temporal blockade of mononuclear phagocyte system (MPS) through the interaction with other biocompatible nanoparticles. Liposomes are excellent candidates as blocking agents, but the efficiency of the MPS blockade can greatly depend on the liposome properties. Here, we investigated the dependence of the efficiency of the induced MPS blockade <i>in vitro</i> and <i>in vivo</i> on the size of blocking liposomes in the 100–500 nm range. Saturation of RAW 264.7 macrophage uptake was observed for phosphatidylcholine/cholesterol liposomes larger than 200 nm <i>in vitro</i>. In mice, liposomes of all sizes exhibited a blocking effect on liver macrophages, prolonging the circulation of subsequently administrated magnetic nanoparticles in the bloodstream, reducing their liver uptake, and increasing accumulation in the spleen and lungs. Importantly, these effects became more pronounced with the increase of liposome size. Optimization of the size of the blocking liposomes holds the potential to enhance drug delivery and improve cancer therapy.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7e6f">https://doi.org/10.1088/1748-605X/ad7e6f</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7e6b" class="art-list-item-title event_main-link">Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis</a> <p class="small art-list-item-meta"> Md Ali Mujtaba <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065016 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis" data-link-purpose-append-open="Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7e6b/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis</span></a> <a href="/article/10.1088/1748-605X/ad7e6b/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Development of chitosan/sodium carboxymethyl cellulose-based polyelectrolyte complex of dexamethasone for treatment of anterior uveitis</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Anterior uveitis is one of the most prevalent forms of ocular inflammation caused by infections, trauma, and other idiopathic conditions if not treated properly, it can cause complete blindness. Therefore, this study aimed to formulate and evaluate dexamethasone sodium phosphate (DSP) loaded polyelectrolyte complex (PEC) nanoparticles (NPs) for the treatment of anterior uveitis. DSP-loaded PEC-NPs were formed through complex coacervation by mixing low molecular weight chitosan and the anionic polymer carboxy methyl cellulose (CMC). The formulations were optimized using Box–Behnken design and evaluated the effect of independent variables: Chitosan concentration, CMC concentration, and pH of chitosan solution on the dependent variables: particle size (PS), Polydispersity Index (PDI), pH of the formulation, and % entrapment efficacy (%EE). The PS, PDI, zeta potential, and pH of the optimized formulation were found 451 ± 82.0995 nm, 0.3807 ± 0.1862, +20.33 ± 1.04 mV and 6.8367 ± 0.0737 respectively. The %EE and drug loading of formulation were 61.66 ± 4.2914% and 21.442 ± 1.814% respectively. <i>In vitro</i> drug release studies of optimized formulation showed the prolonged release up to 12 h whereas, the marketed formulation showed the burst release 85.625 ± 4.3062% in 1 h and 98.1462 ± 3.0921% at 6 h, respectively. Fourier transform infrared studies suggested the effective incorporation of the drug into the PEC-NPs formulation whereas differential scanning calorimetry and x-ray diffraction studies showed the amorphized nature of the drug in the formulation. Transmission electron microscopy study showed self-assembled, nearly spherical, core–shell nanostructures. The corneal permeation study showed higher permeation of the drug from PEC-NPs compared to the marketed formulation. Hen's Eggs test-Chorioallantoic Membrane test of the optimized formulation revealed non-irritant and safe for ocular administration. Therefore, DSP-loaded PEC-NPs are an effective substitute for conventional eye drops due to their ability to increase bioavailability through longer precorneal retention duration and sustained drug release.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7e6b">https://doi.org/10.1088/1748-605X/ad7e6b</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad76f1" class="art-list-item-title event_main-link">Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma</a> <p class="small art-list-item-meta"> Shirin B Hanaei <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065008 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma" data-link-purpose-append-open="Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad76f1/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma</span></a> <a href="/article/10.1088/1748-605X/ad76f1/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Osteosarcoma (OS) is the mostly commonly occurring primary bone cancer. Despite comprehensive treatment programs including neoadjuvant chemotherapy and tumour resection, survival rates have not improved significantly since the 1970s. Survival rates are dramatically reduced for patients who suffer a local recurrence. Furthermore, primary bone cancer patients are at increased risk of bone fractures. Consequently, there is an urgent need for alternative treatment options. In this paper we report the development of novel gallium doped bioactive glass that selectively kill bone cancer cells whilst simultaneously stimulating new bone growth. Here we show, using a combination of 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide, LIVE/DEAD assays and image analysis, that bioactive glasses containing gallium oxide are highly toxic and reduce both the proliferation and migration of bone cancer cells (Saos-2) in a dose dependant manner. Glasses containing 5 mol% gallium oxide reduced the viability of OS cells by 99% without being cytotoxic to the non-cancerous normal human osteoblasts (NHOst) control cells. Furthermore, Fourier transform infrared and energy-dispersive x-ray spectroscopy results confirmed the formation of an amorphous calcium phosphate/hydroxyapatite like layer on the surface of the bioactive glass particulates, after 7 d incubating in simulated body fluid, indicating the early stages of bone formation. These materials show significant potential for use in bone cancer applications as part of a multimodal treatment.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad76f1">https://doi.org/10.1088/1748-605X/ad76f1</a> </div> </div> </div> </div> <div class="art-list-item reveal-container reveal-closed"> <div class="art-list-item-body"> <div class="eyebrow"> <span class="offscreen-hidden">The following article is </span><span class="red">Open access</span> </div> <a href="/article/10.1088/1748-605X/ad7562" class="art-list-item-title event_main-link">Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing</a> <p class="small art-list-item-meta"> L Scaccini <em>et al</em> 2024 <em>Biomed. Mater.</em> <b>19</b> 065005 </p> <div class="art-list-item-tools small wd-abstr-upper"> <button type="button" class="reveal-trigger mr-2 nowrap"> <svg aria-hidden="true" class="fa-icon fa-icon--left fa-icon--flip" role="img" focusable="false" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path d="M137.4 374.6c12.5 12.5 32.8 12.5 45.3 0l128-128c9.2-9.2 11.9-22.9 6.9-34.9s-16.6-19.8-29.6-19.8L32 192c-12.9 0-24.6 7.8-29.6 19.8s-2.2 25.7 6.9 34.9l128 128z"/></svg><span class="reveal-trigger-label" data-reveal-text="Open abstract" data-reveal-label-alt="Close abstract" data-link-purpose-append="Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing" data-link-purpose-append-open="Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing">Open abstract</span> </button> <a href="/article/10.1088/1748-605X/ad7562/meta" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="View article"> <span class="icon-article"></span>View article<span class="offscreen-hidden">, Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing</span></a> <a href="/article/10.1088/1748-605X/ad7562/pdf" class="mr-2 mb-0 nowrap event_mini-link" data-event-action="PDF"><span class="icon-file-pdf"></span>PDF<span class="offscreen-hidden">, Glycerol-blended chitosan membranes with directional micro-grooves and reduced stiffness improve Schwann cell wound healing</span></a> </div> <div class="reveal-content"> <div class="article-text view-text-small"><p>Regenerative medicine is continuously looking for new natural, biocompatible and possibly biodegradable materials, but also mechanically compliant. Chitosan is emerging as a promising FDA-approved biopolymer for tissue engineering, however, its exploitation in regenerative devices is limited by its brittleness and can be further improved, for example by blending it with other materials or by tuning its superficial microstructure. Here, we developed membranes made of chitosan (Chi) and glycerol, by solvent casting, and micro-patterned them with directional geometries having different levels of axial symmetry. These membranes were characterized by light microscopies, atomic force microscopy (AFM), by thermal, mechanical and degradation assays, and also tested <i>in vitro</i> as scaffolds with Schwann cells (SCs). The glycerol-blended Chi membranes are optimized in terms of mechanical properties, and present a physiological-grade Young's modulus (≈0.7 MPa). The directional topographies are effective in directing cell polarization and migration and in particular are highly performant substrates for collective cell migration. Here, we demonstrate that a combination of a soft compliant biomaterial and a topographical micropatterning can improve the integration of these scaffolds with SCs, a fundamental step in the peripheral nerve regeneration process.</p></div> <div class="art-list-item-tools small wd-abstr-lower"> <a class="mr-2" href="https://doi.org/10.1088/1748-605X/ad7562">https://doi.org/10.1088/1748-605X/ad7562</a> </div> </div> </div> </div> </div>  <p> <a href="/nsearch?currentPage=1&terms=&nextPage=2&previousPage=-1&searchDatePeriod=anytime&journals=1748-605X&accessType=open-access&orderBy=newest&pageLength=20">More Open Access articles</a> </p> </div> </div> </div>    </div>    <aside aria-label="Main column advert"> <div id='div-gpt-ad-1562594774007-0' style='width: 728px; height: 90px; display: block;'> <script> googletag.cmd.push(function () { googletag.display('div-gpt-ad-1562594774007-0'); }); </script> </div> </aside>   </div>  </div> </main> <div class="db2 tb2"> <div class="side-and-below">  <div class="sidebar-list" id="wd-jnl-links"> <h2 class="sidebar-list__heading">Journal links</h2> <ul class="sidebar-list__list"><li><a href="https://iopscience.iop.org/journal/1748-605X/page/submission-options" class="linkArrow normal link3"target="_blank"><b>Submit an article</b></a></li> <li><a href="https://publishingsupport.iopscience.iop.org/journals/biomedical-materials/about-biomedical-materials/">About the journal</a></li> <li><a href="https://publishingsupport.iopscience.iop.org/journals/biomedical-materials/editorial-board/">Editorial Board</a></li> <li><a href="https://publishingsupport.iopscience.iop.org/journals/biomedical-materials/">Author guidelines</a></li> <li><a href="https://publishingsupport.iopscience.iop.org/questions/volunteering-to-be-a-journal-reviewer">Review for this journal</li> <li><a href="https://publishingsupport.iopscience.iop.org/journals/biomedical-materials/about-biomedical-materials/#publication-charges">Publication charges</a></li> <li><a href="https://publishingsupport.iopscience.iop.org/questions/biomedical-materials-outstanding-reviewer-awards-2023">Awards</a></li> <li><a href="/1748-605X/page/Journal_Collections">Journal collections</a></li> <li><a href="https://ioppublishing.org/librarians/">Pricing and ordering</a></li> <li><a href="/1748-605X/page/Contact_us">Contact us</a></li></ul> </div>    <aside role="complementary" aria-label="Right sidebar adverts"> <div id='div-gpt-ad-1669279847892-0' style='min-width: 160px; 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