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<!doctype html> <html lang="en" data-reactroot=""><head><link as="script" href="https://www.afr.com/afx_prid/2023.10.16.1/auth/ps/p202310161.js?lcsid=D3377D70-045F-4C2C-B07F-C88533E87E67" rel="preload"/><script>var afx_start = Date.now();</script><script src="https://www.afr.com/afx_prid/2023.10.16.1/auth/ps/p202310161.js?lcsid=D3377D70-045F-4C2C-B07F-C88533E87E67"></script><meta content="text/html; charset=utf-8" http-equiv="Content-Type"/><meta content="width=device-width, initial-scale=1.0" name="viewport"/><title data-rh="true">ASX-listed biotech PYC Therapeutics could land Alan Tribe back on the Rich List</title><link href="//api.ffx.io" rel="dns-prefetch"/><link href="//api.afr.com" rel="dns-prefetch"/><link href="//static.ffx.io" rel="dns-prefetch"/><link href="//www.googletagmanager.com" rel="dns-prefetch"/><link crossorigin="anonymous" href="https://adservice.google.com" rel="preconnect"/><link crossorigin="anonymous" href="https://buy-au.piano.io" rel="preconnect"/><link 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https://static.ffx.io/images/$width_200%2C$height_200/t_crop_fill%2Cq_auto:best%2Cfl_any_format/cdd38c4b4a94da7cc46d9394cd2ba68b4cb4d09e 2x"],"width":100,"aspectRatio":1,"type":"square1x1"}" width="100" height="100"/></picture></figure><div class="_3959bc2afca9734c4ac8"><span class="_14ba773353b3ed4f3dd1 _9f5147e4a4645307537b"><span class="ef988498234ab6593894" data-testid="AuthorNames"><strong><a class="_6d886948f96f9997dca8" data-testid="AuthorURL" href="/by/yolanda-redrup-j7gdq">Yolanda Redrup</a></strong></span></span><span class="f5bfc724af8f77e11685">Rich List Editor</span></div></div><section class="_9378535800c594b7485c"><div class="_4d22830be8e035459d36" data-testid="ArticleTimestamp"><time data-testid="ArticleTimestamp-time">Nov 22, 2024 – 4.43pm</time></div><div class="_2a6dc840ff6bc204ff53" data-testid="ArticleTools"><div class="_9f146e4c46884f388d0e"><button aria-describedby="articleToolsLoginTooltip" class="_13dba38c2689588db954 _7cd6d3a619318b4274cf" 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href="https://subscribe.afr.com/?promote_channel=HI_AGFT_GNL_GIFTCTA&utm_source=ArticleGifting&utm_medium=HouseInventory&utm_campaign=General&utm_content=GiftCTA" class="f6dfc6f770f1c16f22f5">Subscribe now</a><p class="_1c7a5940e3812685c336">Already a subscriber?<!-- --> <button data-testid="Modal-login-button" type="button">Login</button></p></div></div></div></div></div></section></section><div class="_7653fd52bc3d0a84caca _7c5f7f871bf4797f6a64"><div class="d747b0326f1285bf4d90" id="endOfArticle"><p>One of Western Australia’s wealthiest people, Alan Tribe, is poised to rejoin the ranks of the richest 200 Australians, driven by a stellar performance from a listed biotech stock that’s edging closer to a $1 billion valuation.</p><p>Mr Tribe is best known as the former owner of the IKEA franchises in Western Australia and South Australia, which he <a href="https://www.afr.com/companies/retail/ikea-australia-buys-out-wa-sa-franchisee-20170202-gu494u">sold to IKEA Retail Australia in 2017</a>. But, it is biotech stock PYC Therapeutics that will soon make up the largest share of his net worth.</p><div class="_398b6c5e39701f15a1a2">Loading...<figure></figure><figure></figure><figure></figure><figure></figure></div><div></div></div><div class="_2e1de52e69e1d969aea3"><div class="a368146c81ee0410b134"><span class="_1a6f5d6fad2874362309" data-testid="AuthorCard"><span><strong><a class="d1dba0c3091a3c30ebd6" data-testid="AuthorURL" href="/by/yolanda-redrup-j7gdq">Yolanda Redrup</a></strong> is the editor of the AFR Rich List. She previously reported on technology, healthcare and Street Talk.</span><span class="ebf04f7a6858148cabbd _449cf37f9ae646047903" data-testid="Author-Social"><span> <!-- -->Connect with <!-- -->Yolanda<!-- --> on <a class="_86e1121a0a44d2d45f97" href="//twitter.com/YolandaRedrup?lang=en" rel="noopener noreferrer" target="_blank">Twitter</a>.</span><span> <!-- -->Email <!-- -->Yolanda<!-- --> at <a class="c5a5b7d2f686623f7687" href="mailto:yolanda.redrup@afr.com">yolanda.redrup@afr.com</a></span></span></span></div></div><div class="a3b28a4f67a674b57863" data-testid="ArticleFooter"><div class="_9e5858bb5e9aa47354b4"><div class="_9f146e4c46884f388d0e"><button aria-describedby="articleFooterLoginTooltip" class="_13dba38c2689588db954 _7cd6d3a619318b4274cf" data-click-outside-ignore="true" data-testid="SaveArticle-button" type="button"><span class="_82522fbabfe2be1d6f63"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 24 24" class="dd6db77aa2c85e94be85" focusable="false" 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But, it is biotech stock PYC Therapeutics that will soon make up the largest share of his net worth.\u003C\u002Fp\u003E\u003Cp\u003EThe business, which has a pipeline of RNA-based drugs to treat rare conditions such as blinding eye diseases and polycystic kidney disease, is trading up almost 140 per cent in the past 12 months, fetching a market capitalisation of $868 million.\u003C\u002Fp\u003E\u003Cx-placeholder id=\"54b04b015836a5437bef357f6a3220a93c592ab3\"\u003E\u003C\u002Fx-placeholder\u003E\u003Cp\u003EMr Tribe, who owns 34 per cent of the business, first invested in 2017 when it was named Phylogica and traded at less than 5¢. On comparable terms, the business now fetches 19¢ but has recently gone through a 10-to-one share consolidation.\u003C\u002Fp\u003E\u003Cp\u003EIt started out as a minor investment but in the subsequent years he has doubled down time and time again, and in April 2018 he became chairman of the board.\u003C\u002Fp\u003E\u003Cp\u003EUnder chief executive Rohan Hockings and Mr Tribe, the business transitioned from what was effectively a shell company with a library of peptides to a drug discovery and development company. That transformation is now yielding results.\u003C\u002Fp\u003E\u003Cp\u003E“I had made a promise to myself that I’d never get on the board of another listed company, but I broke that promise and it’s been a great success,” Mr Tribe told \u003Cem\u003EThe Australian Financial Review.\u003C\u002Fem\u003E\u003C\u002Fp\u003E\u003Cp\u003E“I’m confident that we’ll get a drug, and probably more than one ... into the market.”\u003C\u002Fp\u003E\u003Cp\u003EMr Tribe last appeared on the Financial Review Rich List in 2018, \u003Cx-placeholder id=\"653021e3cc484d0eb84f9518c1a91d1839a38e64\"\u003E\u003C\u002Fx-placeholder\u003E, with a net worth of $401 million.\u003C\u002Fp\u003E\u003Cp\u003EThe share price surge in 2024 has catapulted Mr Tribe’s estimated net worth to more than $700 million, putting him in contention for the 2025 Rich List.\u003C\u002Fp\u003E\u003Cp\u003EThe company, which is due to release new pre-clinical data next week, is finalising a phase 1\u002F2 clinical trial for its most advanced asset – a vaccination it hopes will reverse some of the effects of a rare eye disease called retinitis pigmentosa, for which there is no cure or standard treatment. It expects to begin a phase three trial next year.\u003C\u002Fp\u003E\u003Cp\u003EIt also has regulatory approval to commence human trials for a second rare eye disease and is in the final stages of pre-clinical trials for a drug to treat a type of polycystic kidney disease, which can result in a person’s kidneys swelling to 20 kilograms.\u003C\u002Fp\u003E\u003Cx-placeholder id=\"036c8347ba24bdadb800e115ead779ddda74645d\"\u003E\u003C\u002Fx-placeholder\u003E\u003Cp\u003EThe business has chosen to target rare diseases that affect the most people – giving the company the dual benefit of a faster regulatory path to market via various US Food and Drug Administration programs, but also a relatively sizeable pool of patients and a hefty $US200,000-odd per year price tag.\u003C\u002Fp\u003E\u003Cp\u003EDr Hockings, who is a trained doctor but has also worked for McKinsey & Company, believes the business should be revenue-generating by 2027 and could have FDA approval for three drugs by late 2028.\u003C\u002Fp\u003E\u003Cp\u003EHe said he was excited to have finally hit a tipping point for the company, but was also exhausted.\u003C\u002Fp\u003E\u003Cp\u003E“If I had my time again I don’t know [if I’d take on the CEO role] it’s been a long and treacherous road,” Dr Hockings said.\u003C\u002Fp\u003E\u003Cp\u003E“This is an industry that’s controlled by and totally dominated by the US … we’ve [also] just endured the tech wreck … where companies that have long-dated future cash flows that are at high risk in terms of realisation have not been in favour at all.\u003C\u002Fp\u003E\u003Cp\u003E“In biotech, the more successful you are, the more money you spend. You’re stuck in this awful paradigm where you have this terrible valuation, and you don’t want to issue any more script … but you’re kind of obliged to because you’ve had technical success.”\u003C\u002Fp\u003E\u003Cp\u003ECapital raising is at the forefront of the company’s mind, with PYC’s cash runway only extending to mid-2025.\u003C\u002Fp\u003E\u003Cp\u003ESince first investing in 2017, Mr Tribe has participated in every capital raise.\u003C\u002Fp\u003E\u003Cp\u003E“We will need more funding … but we’ve hit the watershed [moment] and the interest from investors both in Australia and North America is now at a high level,” he said.\u003C\u002Fp\u003E\u003Cp\u003E“Similarly, there is interest from major pharmaceutical companies in our individual programs … So I don’t have any concerns about [raising capital].”\u003C\u002Fp\u003E\u003Cp\u003EThe biotech market, Mr Tribe said, was improving across the board, albeit from a low level of investor interest.\u003C\u002Fp\u003E\u003Cp\u003EMr Tribe typically only invests in businesses he’s involved in and does not hold meaningful positions in any other stocks. Likewise, he’s “sitting out” of real estate at the moment.\u003C\u002Fp\u003E\u003Cp\u003EMany local biotech companies with promising drug candidates sell their assets to larger pharmaceutical companies which are better funded to support costly phase three trials.\u003C\u002Fp\u003E\u003Cp\u003EThat, however, is not Mr Tribe’s intention. He does not want an Australian invention to be lost offshore. This was the case with the University of Western Australia’s RNA therapy for Duchenne muscular dystrophy, which was licensed to fledgling US company Sarepta in 2013 and is now a $US10 billion business.\u003C\u002Fp\u003E\u003Cp\u003E“I didn’t come into the company to sell it, or to sell its drugs, I had this sort of slightly ambitious hope that we might be able to build a serious pharmaceutical company in Australia from the ground up and I still retain that hope now.”\u003C\u002Fp\u003E\u003Cp\u003EWhile Dr Hocking said this was an admirable vision of Mr Tribe’s, and it could pan out, having led the company through its turnaround, he’s realistic about the difficulties.\u003C\u002Fp\u003E\u003Cp\u003E“It is possible to do it … the hard yards have been done … but the journey we’ve been on shows just how hard the ecosystem is here,” he said.\u003C\u002Fp\u003E\u003Cx-placeholder id=\"2028abb1d0ab895ad9b7300580d08df85c9e9c17\"\u003E\u003C\u002Fx-placeholder\u003E\u003Cx-placeholder id=\"e34a3b1c87393005d604193e1b06982c84c9cbdc\"\u003E\u003C\u002Fx-placeholder\u003E","bodyPlaceholders":{"036c8347ba24bdadb800e115ead779ddda74645d":{"data":{"altText":"","animated":false,"aspect":1.5,"autoCrop":false,"caption":"Dr Hockings says the journey to transform PYC has been “treacherous”.","credit":"Ross Swanborough","cropWidth":756,"fileName":"350950e8291f532f1bb4987adae5952e4f665793","id":"350950e8291f532f1bb4987adae5952e4f665793","mimeType":"image\u002Fjpeg","offsetX":0,"offsetY":0,"originalHeight":null,"originalWidth":null,"source":"Australian Financial Review","zoom":0.189},"type":"image"},"2028abb1d0ab895ad9b7300580d08df85c9e9c17":{"data":{"id":"gu494u"},"type":"relatedStory"},"54b04b015836a5437bef357f6a3220a93c592ab3":{"data":{"altText":"","animated":false,"aspect":1.5,"autoCrop":false,"caption":"Dr Rohan Hockings and Alan Tribe have led the turnaround of PYC Therapeutics.","credit":"Ross Swanborough","cropWidth":756,"fileName":"a9db55d941dfc3382be409d69405919a8c0da5ac","id":"a9db55d941dfc3382be409d69405919a8c0da5ac","mimeType":"image\u002Fjpeg","offsetX":0,"offsetY":0,"originalHeight":null,"originalWidth":null,"source":"Australian Financial Review","zoom":0.189},"type":"image"},"653021e3cc484d0eb84f9518c1a91d1839a38e64":{"data":{"newTab":false,"noFollow":false,"text":"ranked 197th","url":"https:\u002F\u002Fwww.afr.com\u002Fwealth\u002Fpeople\u002Frich-list-overview-20180413-h0yqo5"},"type":"linkExternal"},"6dcaaf77c7ef2569ad168da6f92bc1b70c55f6bd":{"data":{"newTab":false,"noFollow":false,"text":"sold to IKEA Retail Australia in 2017","url":"https:\u002F\u002Fwww.afr.com\u002Fcompanies\u002Fretail\u002Fikea-australia-buys-out-wa-sa-franchisee-20170202-gu494u"},"type":"linkExternal"},"e34a3b1c87393005d604193e1b06982c84c9cbdc":{"data":{"id":"p5kbtv"},"type":"relatedStory"}},"byline":"Yolanda Redrup","closeComments":false,"headlines":{"headline":"The stock set to propel one of WA’s richest back onto the Rich List"},"wordCount":977},"dates":{"created":"2024-11-19T23:03:33Z","firstPublished":"2024-11-22T05:43:09Z","imported":"2024-11-22T05:43:10.480908018Z","modified":"2024-11-22T05:43:09Z","published":"2024-11-22T05:43:09Z","saved":"2024-11-22T05:43:09Z"},"editingState":"ready","id":"p5ks3m","featuredImages":{"landscape16x9":{"data":{"aspect":1.777778,"caption":"Dr Rohan Hockings and Alan Tribe have led the turnaround of PYC Therapeutics.","credit":"Ross Swanborough","cropWidth":1059,"fileName":"a9db55d941dfc3382be409d69405919a8c0da5ac","id":"a9db55d941dfc3382be409d69405919a8c0da5ac","mimeType":"image\u002Fjpeg","offsetX":239,"offsetY":0,"source":"Australian Financial Review","zoom":0.4578}},"landscape3x2":{"data":{"aspect":1.5,"caption":"Dr Rohan Hockings and Alan Tribe have led the turnaround of PYC Therapeutics.","credit":"Ross Swanborough","cropWidth":756,"fileName":"a9db55d941dfc3382be409d69405919a8c0da5ac","id":"a9db55d941dfc3382be409d69405919a8c0da5ac","mimeType":"image\u002Fjpeg","offsetX":271,"offsetY":0,"source":"Australian Financial Review","zoom":0.3871}},"portrait2x3":{"data":{"aspect":0.666667,"caption":"Dr Rohan Hockings and Alan Tribe have led the turnaround of PYC Therapeutics.","credit":"Ross Swanborough","cropWidth":378,"fileName":"a9db55d941dfc3382be409d69405919a8c0da5ac","id":"a9db55d941dfc3382be409d69405919a8c0da5ac","mimeType":"image\u002Fjpeg","offsetX":296,"offsetY":0,"source":"Australian Financial Review","zoom":0.2893}},"square1x1":{"data":{"aspect":1,"caption":"Dr Rohan Hockings and Alan Tribe have led the turnaround of PYC Therapeutics.","credit":"Ross Swanborough","cropWidth":378,"fileName":"a9db55d941dfc3382be409d69405919a8c0da5ac","id":"a9db55d941dfc3382be409d69405919a8c0da5ac","mimeType":"image\u002Fjpeg","offsetX":296,"offsetY":0,"source":"Australian Financial Review","zoom":0.2892}}},"participants":{"authors":[{"bio":"Yolanda Redrup is the editor of the AFR Rich List. 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