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microsphere</title> <meta name="description" content="Search results for: microsphere"> <meta name="keywords" content="microsphere"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="microsphere"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 19</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: microsphere</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Modeling and Validation of Microspheres Generation in the Modified T-Junction Device</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lei%20Lei">Lei Lei</a>, <a href="https://publications.waset.org/abstracts/search?q=Hongbo%20Zhang"> Hongbo Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Donald%20J.%20Bergstrom"> Donald J. Bergstrom</a>, <a href="https://publications.waset.org/abstracts/search?q=Bing%20Zhang"> Bing Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Y.%20Song"> K. Y. Song</a>, <a href="https://publications.waset.org/abstracts/search?q=W.%20J.%20Zhang"> W. J. Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents a model for a modified T-junction device for microspheres generation. The numerical model is developed using a commercial software package: COMSOL Multiphysics. In order to test the accuracy of the numerical model, multiple variables, such as the flow rate of cross-flow, fluid properties, structure, and geometry of the microdevice are applied. The results from the model are compared with the experimental results in the diameter of the microsphere generated. The comparison shows a good agreement. Therefore the model is useful in further optimization of the device and feedback control of microsphere generation if any. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CFD%20modeling" title="CFD modeling">CFD modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=validation" title=" validation"> validation</a>, <a href="https://publications.waset.org/abstracts/search?q=microsphere%20generation" title=" microsphere generation"> microsphere generation</a>, <a href="https://publications.waset.org/abstracts/search?q=modified%20T-junction" title=" modified T-junction"> modified T-junction</a> </p> <a href="https://publications.waset.org/abstracts/20156/modeling-and-validation-of-microspheres-generation-in-the-modified-t-junction-device" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20156.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">707</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Enhancement in Bactericidal Activity of Hydantoin Based Microsphere from Smooth to Rough</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rajani%20Kant%20Rai">Rajani Kant Rai</a>, <a href="https://publications.waset.org/abstracts/search?q=Jayakrishnan%20Athipet"> Jayakrishnan Athipet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> There have been several attempts to prepare polymers with antimicrobial properties by doping with various N-halamines. Hydantoins (Cyclic N-halamine) is of importance due to their stability rechargeable chloroamide function, broad-spectrum anti-microbial action and ability to prevent resistance to the organisms. Polymerizable hydantoins are synthesized by tethering vinyl moieties to 5,5,-dialkyl hydantoin sacrificing the imide hydrogen in the molecule thereby restricting the halogen capture only to the amide nitrogen that results in compromised antibacterial activity. In order to increase the activity of the antimicrobial polymer, we have developed a scheme to maximize the attachment of chlorine to the amide and the imide moieties of hydantoin. Vinyl hydantoin monomer, (Z)-5-(4-((3-methylbuta-1,3-dien-2-yl)oxy)benzylidene)imidazolidine-2,4-dione (MBBID) was synthesized and copolymerized with a commercially available monomer, methyl methacrylate, by free radical polymerization. The antimicrobial activity of hydantoin is strongly dependent on their surface area and hence their microbial activity increases when incorporated in microspheres or nanoparticles as compared to their bulk counterpart. In this regard, smooth and rough surface microsphere of the vinyl monomer (MBBID) with commercial monomer was synthesized. The oxidative chlorine content of the copolymer ranged from 1.5 to 2.45 %. Further, to demonstrate the water purification potential, the thin column was packed with smooth or rough microspheres and challenged with simulated contaminated water that exhibited 6 log kill (total kill) of the bacteria in 20 minutes of exposure with smooth (25 mg/ml) and rough microsphere (15.0 mg/ml). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cyclic%20N-halamine" title="cyclic N-halamine">cyclic N-halamine</a>, <a href="https://publications.waset.org/abstracts/search?q=vinyl%20hydantoin%20monomer" title=" vinyl hydantoin monomer"> vinyl hydantoin monomer</a>, <a href="https://publications.waset.org/abstracts/search?q=rough%20surface%20microsphere" title=" rough surface microsphere"> rough surface microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=simulated%20contaminated%20water" title=" simulated contaminated water"> simulated contaminated water</a> </p> <a href="https://publications.waset.org/abstracts/96510/enhancement-in-bactericidal-activity-of-hydantoin-based-microsphere-from-smooth-to-rough" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96510.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">145</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Application of MRI in Radioembolization Imaging and Dosimetry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salehi%20Zahabi%20Saleh">Salehi Zahabi Saleh</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajabi%20Hosaien"> Rajabi Hosaien</a>, <a href="https://publications.waset.org/abstracts/search?q=Rasaneh%20Samira"> Rasaneh Samira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Yttrium-90 (90Y) radioembolisation(RE) is increasingly used for the treatment of patients with unresectable primary or metastatic liver tumours. Image-based approaches to assess microsphere distribution after RE have gained interest but are mostly hampered by the limited imaging possibilities of the Isotope 90Y. Quantitative 90Y-SPECT imaging has limited spatial resolution because it is based on 90Y Bremsstrahlung whereas 90Y-PET has better spatial resolution but low sensitivity. As a consequence, new alternative methods of visualizing the microspheres have been investigated, such as MR imaging of iron-labelled microspheres. It was also shown that MRI combines high sensitivity with high spatial and temporal resolution and with superior soft tissue contrast and thus can be used to cover a broad range of clinically interesting imaging parameters.The aim of the study in this article was to investigate the capability of MRI to measure the intrahepatic microsphere distribution in order to quantify the absorbed radiation dose in RE. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=radioembolisation" title="radioembolisation">radioembolisation</a>, <a href="https://publications.waset.org/abstracts/search?q=MRI" title=" MRI"> MRI</a>, <a href="https://publications.waset.org/abstracts/search?q=imaging" title=" imaging"> imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=dosimetry" title=" dosimetry"> dosimetry</a> </p> <a href="https://publications.waset.org/abstracts/45127/application-of-mri-in-radioembolization-imaging-and-dosimetry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45127.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">320</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Polymeric Microspheres for Bone Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yamina%20Boukari">Yamina Boukari</a>, <a href="https://publications.waset.org/abstracts/search?q=Nashiru%20Billa"> Nashiru Billa</a>, <a href="https://publications.waset.org/abstracts/search?q=Andrew%20Morris"> Andrew Morris</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephen%20Doughty"> Stephen Doughty</a>, <a href="https://publications.waset.org/abstracts/search?q=Kevin%20Shakesheff"> Kevin Shakesheff</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Poly (lactic-co-glycolic) acid (PLGA) is a synthetic polymer that can be used in bone tissue engineering with the aim of creating a scaffold in order to support the growth of cells. The formation of microspheres from this polymer is an attractive strategy that would allow for the development of an injectable system, hence avoiding invasive surgical procedures. The aim of this study was to develop a microsphere delivery system for use as an injectable scaffold in bone tissue engineering and evaluate various formulation parameters on its properties. Porous and lysozyme-containing PLGA microspheres were prepared using the double emulsion solvent evaporation method from various molecular weights (MW). Scaffolds were formed by sintering to contain 1 -3mg of lysozyme per gram of scaffold. The mechanical and physical properties of the scaffolds were assessed along with the release of lysozyme, which was used as a model protein. The MW of PLGA was found to have an influence on microsphere size during fabrication, with increased MW leading to an increased microsphere diameter. An inversely proportional relationship was displayed between PLGA MW and mechanical strength of formed scaffolds across loadings for low, intermediate and high MW respectively. Lysozyme release from both microspheres and formed scaffolds showed an initial burst release phase, with both microspheres and scaffolds fabricated using high MW PLGA showing the lowest protein release. Following the initial burst phase, the profiles for each MW followed a similar slow release over 30 days. Overall, the results of this study demonstrate that lysozyme can be successfully incorporated into porous PLGA scaffolds and released over 30 days in vitro, and that varying the MW of the PLGA can be used as a method of altering the physical properties of the resulting scaffolds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone" title="bone">bone</a>, <a href="https://publications.waset.org/abstracts/search?q=microspheres" title=" microspheres"> microspheres</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title=" tissue engineering"> tissue engineering</a> </p> <a href="https://publications.waset.org/abstracts/24045/polymeric-microspheres-for-bone-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24045.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">425</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Hydrogel Hybridizing Temperature-Cured Dissolvable Gelatin Microspheres as Non-Anchorage Dependent Cell Carriers for Tissue Engineering Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dong-An%20Wang">Dong-An Wang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> All kinds of microspheres have been extensively employed as carriers for drug, gene and therapeutic cell delivery. Most therapeutic cell delivery microspheres rely on a two-step methodology: fabrication of microspheres and subsequent seeding of cells onto them. In this study, we have developed a novel one-step cell encapsulation technique using a convenient and instant water-in-oil single emulsion approach to form cell-encapsulated gelatin microspheres. This technology is adopted for hyaline cartilage tissue engineering, in which autologous chondrocytes are used as therapeutic cells. Cell viability was maintained throughout and after the microsphere formation (75-100 µm diameters) process that avoids involvement of any covalent bonding reactions or exposure to any further chemicals. Further encapsulation of cell-laden microspheres in alginate gels were performed under 4°C via a prompt process. Upon the formation of alginate constructs, they were immediately relocated into CO2 incubator where the temperature was maintained at 37°C; under this temperature, the cell-laden gelatin microspheres dissolved within hours to yield similarly sized cavities and the chondrocytes were therefore suspended within the cavities inside the alginate gel bulk. Hence, the gelatin cell-laden microspheres served two roles: as cell delivery vehicles which can be removable through temperature curing, and as porogens within an alginate hydrogel construct to provide living space for cell growth and tissue development as well as better permeability for mutual diffusions. These cell-laden microspheres, namely “temperature-cured dissolvable gelatin microsphere based cell carriers” (tDGMCs), were further encapsulated in a chondrocyte-laden alginate scaffold system and analyzed by WST-1, gene expression analyses, biochemical assays, histology and immunochemistry stains. The positive results consistently demonstrated the promise of tDGMC technology in delivering these non-anchorage dependent cells (chondrocytes). It can be further conveniently translated into delivery of other non-anchorage dependent cell species, including stem cells, progenitors or iPS cells, for regeneration of tissues in internal organs, such as engineered hepatogenesis or pancreatic regeneration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomaterials" title="biomaterials">biomaterials</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title=" tissue engineering"> tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=microsphere" title=" microsphere"> microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=porogen" title=" porogen"> porogen</a>, <a href="https://publications.waset.org/abstracts/search?q=anchorage%20dependence" title=" anchorage dependence"> anchorage dependence</a> </p> <a href="https://publications.waset.org/abstracts/4056/hydrogel-hybridizing-temperature-cured-dissolvable-gelatin-microspheres-as-non-anchorage-dependent-cell-carriers-for-tissue-engineering-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/4056.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">396</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Functional Yoghurt Enriched with Microencapsulated Olive Leaves Extract Powder Using Polycaprolactone via Double Emulsion/Solvent Evaporation Technique</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tamer%20El-Messery">Tamer El-Messery</a>, <a href="https://publications.waset.org/abstracts/search?q=Teresa%20Sanchez-Moya"> Teresa Sanchez-Moya</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruben%20Lopez-Nicolas"> Ruben Lopez-Nicolas</a>, <a href="https://publications.waset.org/abstracts/search?q=Gaspar%20Ros"> Gaspar Ros</a>, <a href="https://publications.waset.org/abstracts/search?q=Esmat%20Aly"> Esmat Aly</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Olive leaves (OLs), the main by-product of the olive oil industry, have a considerable amount of phenolic compounds. The exploitation of these compounds represents the current trend in food processing. In this study, OLs polyphenols were microencapsulated with polycaprolactone (PCL) and utilized in formulating novel functional yoghurt. PCL-microcapsules were characterized by scanning electron microscopy, and Fourier transform infrared spectrometry analysis. Their total phenolic (TPC), total flavonoid (TFC) contents, and antioxidant activities (DPPH, FRAP, ABTS), and polyphenols bioaccessibility were measured after oral, gastric, and intestinal steps of in vitro digestion. The four yoghurt formulations (containing 0, 25, 50, and 75 mg of PCL-microsphere/100g yoghurt) were evaluated for their pH, acidity, syneresis viscosity, and color during storage. In vitro digestion significantly affected the phenolic composition in non-encapsulated extract while had a lower impact on encapsulated phenolics. Higher protection was provided for encapsulated OLs extract, and their higher release was observed at the intestinal phase. Yoghurt with PCL-microsphere had lower viscosity, syneresis, and color parameters, as compared to control yoghurt. Thus, OLs represent a valuable and cheap source of polyphenols which can be successfully applied, in microencapsulated form, to formulate functional yoghurt. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=yoghurt%20quality%20attributes" title="yoghurt quality attributes">yoghurt quality attributes</a>, <a href="https://publications.waset.org/abstracts/search?q=olive%20leaves" title=" olive leaves"> olive leaves</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20and%20flavonoids%20compounds" title=" phenolic and flavonoids compounds"> phenolic and flavonoids compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=polycaprolactone%20as%20microencapsulant" title=" polycaprolactone as microencapsulant"> polycaprolactone as microencapsulant</a> </p> <a href="https://publications.waset.org/abstracts/135540/functional-yoghurt-enriched-with-microencapsulated-olive-leaves-extract-powder-using-polycaprolactone-via-double-emulsionsolvent-evaporation-technique" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135540.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Numerical Simulation of Production of Microspheres from Polymer Emulsion in Microfluidic Device toward Using in Drug Delivery Systems</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nizar%20Jawad%20Hadi">Nizar Jawad Hadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sajad%20Abd%20Alabbas"> Sajad Abd Alabbas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Because of their ability to encapsulate and release drugs in a controlled manner, microspheres fabricated from polymer emulsions using microfluidic devices have shown promise for drug delivery applications. In this study, the effects of velocity, density, viscosity, and surface tension, as well as channel diameter, on microsphere generation were investigated using Fluent Ansys software. The software was programmed with the physical properties of the polymer emulsion such as density, viscosity and surface tension. Simulation will then be performed to predict fluid flow and microsphere production and improve the design of drug delivery applications based on changes in these parameters. The effects of capillary and Weber numbers are also studied. The results of the study showed that the size of the microspheres can be controlled by adjusting the speed and diameter of the channel. Narrower microspheres resulted from narrower channel widths and higher flow rates, which could improve drug delivery efficiency, while smaller microspheres resulted from lower interfacial surface tension. The viscosity and density of the polymer emulsion significantly affected the size of the microspheres, ith higher viscosities and densities producing smaller microspheres. The loading and drug release properties of the microspheres created with the microfluidic technique were also predicted. The results showed that the microspheres can efficiently encapsulate drugs and release them in a controlled manner over a period of time. This is due to the high surface area to volume ratio of the microspheres, which allows for efficient drug diffusion. The ability to tune the manufacturing process using factors such as speed, density, viscosity, channel diameter, and surface tension offers a potential opportunity to design drug delivery systems with greater efficiency and fewer side effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polymer%20emulsion" title="polymer emulsion">polymer emulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=microspheres" title=" microspheres"> microspheres</a>, <a href="https://publications.waset.org/abstracts/search?q=numerical%20simulation" title=" numerical simulation"> numerical simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=microfluidic%20device" title=" microfluidic device"> microfluidic device</a> </p> <a href="https://publications.waset.org/abstracts/170799/numerical-simulation-of-production-of-microspheres-from-polymer-emulsion-in-microfluidic-device-toward-using-in-drug-delivery-systems" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170799.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">65</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Spray-Dried, Biodegradable, Drug-Loaded Microspheres for Use in the Treatment of Lung Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazen%20AlGharsan">Mazen AlGharsan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The Carbopol Microsphere of Linezolid, a drug used to treat lung disease (pulmonary disease), was prepared using Buchi B-90 nano spray-drier. Methods: Production yield, drug content, external morphology, particle size, and in vitro release pattern were performed. Results: The work was 79.35%, and the drug content was 66.84%. The surface of the particles was shriveled in shape, with particle size distribution with a mean diameter of 9.6 µm; the drug was released in a biphasic manner with an initial release of 25.2 ± 5.7% at 60 minutes. It later prolonged the release by 95.5 ± 2.5% up to 12 hours. Differential scanning calorimetry (DSC) revealed no change in the melting point of the formulation. Fourier-transform infrared (FT-IR) studies showed no polymer-drug interaction in the prepared nanoparticles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title="nanotechnology">nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=Linezolid" title=" Linezolid"> Linezolid</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20disease" title=" lung disease"> lung disease</a> </p> <a href="https://publications.waset.org/abstracts/193025/spray-dried-biodegradable-drug-loaded-microspheres-for-use-in-the-treatment-of-lung-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193025.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">13</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Environmental Catalysts for Refining Technology Application: Reduction of CO Emission and Gasoline Sulphur in Fluid Catalytic Cracking Unit</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Loganathan%20Kumaresan">Loganathan Kumaresan</a>, <a href="https://publications.waset.org/abstracts/search?q=Velusamy%20Chidambaram"> Velusamy Chidambaram</a>, <a href="https://publications.waset.org/abstracts/search?q=Arumugam%20Velayutham%20Karthikeyani"> Arumugam Velayutham Karthikeyani</a>, <a href="https://publications.waset.org/abstracts/search?q=Alex%20Cheru%20Pulikottil"> Alex Cheru Pulikottil</a>, <a href="https://publications.waset.org/abstracts/search?q=Madhusudan%20Sau"> Madhusudan Sau</a>, <a href="https://publications.waset.org/abstracts/search?q=Gurpreet%20Singh%20Kapur"> Gurpreet Singh Kapur</a>, <a href="https://publications.waset.org/abstracts/search?q=Sankara%20Sri%20Venkata%20Ramakumar"> Sankara Sri Venkata Ramakumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Environmentally driven regulations throughout the world stipulate dramatic improvements in the quality of transportation fuels and refining operations. The exhaust gases like CO, NOx, and SOx from stationary sources (e.g., refinery) and motor vehicles contribute to a large extent for air pollution. The refining industry is under constant environmental pressure to achieve more rigorous standards on sulphur content in the fuel used in the transportation sector and other off-gas emissions. Fluid catalytic cracking unit (FCCU) is a major secondary process in refinery for gasoline and diesel production. CO-combustion promoter additive and gasoline sulphur reduction (GSR) additive are catalytic systems used in FCCU to assist the combustion of CO to CO₂ in the regenerator and regulate sulphur in gasoline faction respectively along with main FCC catalyst. Effectiveness of these catalysts is governed by the active metal used, its dispersion, the type of base material employed, and retention characteristics of additive in FCCU such as attrition resistance and density. The challenge is to have a high-density microsphere catalyst support for its retention and high activity of the active metals as these catalyst additives are used in low concentration compare to the main FCC catalyst. The present paper discusses in the first part development of high dense microsphere of nanocrystalline alumina by hydro-thermal method for CO combustion promoter application. Performance evaluation of additive was conducted under simulated regenerator conditions and shows CO combustion efficiency above 90%. The second part discusses the efficacy of a co-precipitation method for the generation of the active crystalline spinels of Zn, Mg, and Cu with aluminium oxides as an additive. The characterization and micro activity test using heavy combined hydrocarbon feedstock at FCC unit conditions for evaluating gasoline sulphur reduction activity are studied. These additives were characterized by X-Ray Diffraction, NH₃-TPD & N₂ sorption analysis, TPR analysis to establish structure-activity relationship. The reaction of sulphur removal mechanisms involving hydrogen transfer reaction, aromatization and alkylation functionalities are established to rank GSR additives for their activity, selectivity, and gasoline sulphur removal efficiency. The sulphur shifting in other liquid products such as heavy naphtha, light cycle oil, and clarified oil were also studied. PIONA analysis of liquid product reveals 20-40% reduction of sulphur in gasoline without compromising research octane number (RON) of gasoline and olefins content. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrothermal" title="hydrothermal">hydrothermal</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocrystalline" title=" nanocrystalline"> nanocrystalline</a>, <a href="https://publications.waset.org/abstracts/search?q=spinel" title=" spinel"> spinel</a>, <a href="https://publications.waset.org/abstracts/search?q=sulphur%20reduction" title=" sulphur reduction"> sulphur reduction</a> </p> <a href="https://publications.waset.org/abstracts/115690/environmental-catalysts-for-refining-technology-application-reduction-of-co-emission-and-gasoline-sulphur-in-fluid-catalytic-cracking-unit" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/115690.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">97</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Mesoporous Tussah Silk Fibroin Microspheres for Drug Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Weitao%20Zhou">Weitao Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Qing%20Wang"> Qing Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianxin%20He"> Jianxin He</a>, <a href="https://publications.waset.org/abstracts/search?q=Shizhong%20Cui"> Shizhong Cui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mesoporous Tussah silk fibroin (TSF) spheres were fabricated via the self-assembly of TSF molecules in aqueous solutions. The results showed that TSF particles were approximately three-dimensional spheres with the diameter ranging from 500nm to 6μm without adherence. More importantly, the surface morphology is mesoporous structure with nano-pores of 20nm - 200nm in size. Fourier transform infrared (FT-IR) and X-ray diffraction (XRD) studies demonstrated that mesoporous TSF spheres mainly contained beta-sheet conformation (44.1 %) as well as slight amounts of random coil (13.2 %). Drug release test was performed with 5-fluorouracil (5-Fu) as a model drug and the result indicated the mesoporous TSF microspheres had a good capacity of sustained drug release. It is expected that these stable and high-crystallinity mesoporous TSF sphere produced without organic solvents, which have significantly improved drug release properties, is a very promising material for controlled gene medicines delivery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tussah%20silk%20fibroin" title="Tussah silk fibroin">Tussah silk fibroin</a>, <a href="https://publications.waset.org/abstracts/search?q=porous%20materials" title=" porous materials"> porous materials</a>, <a href="https://publications.waset.org/abstracts/search?q=microsphere" title=" microsphere"> microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a> </p> <a href="https://publications.waset.org/abstracts/69674/mesoporous-tussah-silk-fibroin-microspheres-for-drug-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69674.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">459</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Preparation and in vitro Characterisation of Chitosan/Hydroxyapatite Injectable Microspheres as Hard Tissue Substitution</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Maachou">H. Maachou</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Chagnes"> A. Chagnes</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Cote"> G. Cote </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present work reports the properties of chitosan/hydroxyapatite (Cs/HA: 100/00, 70/30 and 30/70) composite microspheres obtained by emulsification processing route. The morphology of chitosane microspheres was observed by a scanning electron microscope (SEM) which shows an aggregate of spherical microspheres with a particle size, determined by optical microscope, ranged from 4 to 10 µm. Thereafter, a biomimetic approach was used to study the in vitro biomineralization of these composites. It concerns the composites immersion in simulated body fluid (SBF) for different times. The deposited calcium phosphate was studied using X-ray diffraction analysis (XRD), FTIR spectroscopy and ICP analysis of phosphorus. In fact, the mineral formed on Cs/HA microspheres was a mixture of carbonated HA and β-TCP as showed by FTIR peaks at 1419,5 and 871,8 cm-1 and XRD peak at 29,5°. This formation was induced by the presence of HA in chitosan microspheres. These results are confirmed by SEM micrographs which chow the Ca-P crystals growth in form of cauliflowers. So, these materials are of great interest for bone regeneration applications due to their ability to nucleate calcium phosphates in presence of simulated body fluid (SBF). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydroxyapatite" title="hydroxyapatite">hydroxyapatite</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=microsphere" title=" microsphere"> microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=composite" title=" composite"> composite</a>, <a href="https://publications.waset.org/abstracts/search?q=bone%20regeneration" title=" bone regeneration"> bone regeneration</a> </p> <a href="https://publications.waset.org/abstracts/12735/preparation-and-in-vitro-characterisation-of-chitosanhydroxyapatite-injectable-microspheres-as-hard-tissue-substitution" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12735.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">330</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Development and In vitro Characterization of Diclofenac-Loaded Microparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Prakriti%20Diwan">Prakriti Diwan</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Saraf"> S. Saraf</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study involves preparation and evaluation of microparticles of diclofenac sodium. The microparticles were prepared by the emulsion solvent evaporation techniques using ethylcellulose polymer. Four different batches of microspheres were prepared by varying the concentration of polymer from 50% to 80% w/w. The microspheres were characterized for drug content, percentage yield and encapsulation efficiency, particle size analysis and surface morphology. Microsphere prepared with high drug content produces higher percentage yield and encapsulation efficiency values. It was observed the increase in concentration of the polymer, increases the mean particle size of the microspheres. The effect of polymer concentration on the in vitro release of diclofenac from the microspheres was also studied. The production microparticles yield showed 98.74%, mean particle size 956.32µm and loading efficiency 97.15%. The results were found that microparticles prepared had slower release than microparticles (p>0.05). Therefore, it may be concluded that drug loaded microparticles are suitable delivery systems for diclofenac sodium. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diclofenac%20sodium" title="diclofenac sodium">diclofenac sodium</a>, <a href="https://publications.waset.org/abstracts/search?q=emulsion%20solvent%20evaporation" title=" emulsion solvent evaporation"> emulsion solvent evaporation</a>, <a href="https://publications.waset.org/abstracts/search?q=ethylcellulose" title=" ethylcellulose"> ethylcellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=microparticles" title=" microparticles"> microparticles</a> </p> <a href="https://publications.waset.org/abstracts/47663/development-and-in-vitro-characterization-of-diclofenac-loaded-microparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47663.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">287</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Development, Optimization and Characterization of Gastroretentive Multiparticulate Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Swapnila%20V.%20Vanshiv">Swapnila V. Vanshiv</a>, <a href="https://publications.waset.org/abstracts/search?q=Hemant%20P.%20Joshi"> Hemant P. Joshi</a>, <a href="https://publications.waset.org/abstracts/search?q=Atul%20B.%20Aware"> Atul B. Aware</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Current study illustrates the formulation of floating microspheres for purpose of gastroretention of Dipyridamole which shows pH dependent solubility, with the highest solubility in acidic pH. The formulation involved hollow microsphere preparation by using solvent evaporation technique. Concentrations of rate controlling polymer, hydrophilic polymer, internal phase ratio, stirring speed were optimized to get desired responses, namely release of Dipyridamole, buoyancy of microspheres, entrapment efficiency of microspheres. In the formulation, the floating microspheres were prepared by using ethyl cellulose as release retardant and HPMC as a low density hydrophilic swellable polymer. Formulated microspheres were evaluated for their physical properties such as particle size and surface morphology by optical microscopy and SEM. Entrapment efficiency, floating behavior and drug release study as well the formulation was evaluated for in vivo gastroretention in rabbits using gamma scintigraphy. Formulation showed 75% drug release up to 10 hr with entrapment efficiency of 91% and 88% buoyancy till 10 hr. Gamma scintigraphic studies revealed that the optimized system was retained in the gastric region (stomach) for a prolonged period i.e. more than 5 hr. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dipyridamole%20microspheres" title="Dipyridamole microspheres">Dipyridamole microspheres</a>, <a href="https://publications.waset.org/abstracts/search?q=gastroretention" title=" gastroretention"> gastroretention</a>, <a href="https://publications.waset.org/abstracts/search?q=HPMC" title=" HPMC"> HPMC</a>, <a href="https://publications.waset.org/abstracts/search?q=optimization%20method" title=" optimization method"> optimization method</a> </p> <a href="https://publications.waset.org/abstracts/8657/development-optimization-and-characterization-of-gastroretentive-multiparticulate-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8657.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">385</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Delivery of Ginseng Extract Containing Phytosome Loaded Microsphere System: A Preclinical Approach for Treatment of Neuropathic Pain in Rodent Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nitin%20Kumar">Nitin Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: The current research work focuses mainly on evolving a delivery system for ginseng extract (GE), which in turn will ameliorate the neuroprotective potential by means of enhancing the ginsenoside (Rb1) bio-availability (BA). For more noteworthy enhancement in oral bioavailability (OBA) along with pharmacological properties, the drug carriers’ performance can be strengthened by utilizing phytosomes-loaded microspheres (PM) delivery system. Methods: For preparing the disparate phytosome complexes (F1, F2, and F3), an aqueous extract of ginseng roots (GR) along with phospholipids were reacted in disparate ratio. Considering the outcomes, F3 formulation (spray-dried) was chosen for preparing the phytosomes powder (PP), PM, and extract microspheres (EM). PM was made by means of loading of F3 into Gum Arabic (GA) in addition to maltodextrin polymer mixture, whereas EM was prepared by means of the addition of extract directly into the same polymer mixture. For investigating the neuroprotective effect (NPE) in addition to their pharmacokinetic (PK) properties, PP, PM, and EM formulations were assessed. Results: F3 formulation gave enhanced entrapment efficiency (EE) (i.e., 50.61%) along with good homogeneity of spherical shaped particle size (PS) (42.58 ± 1.4 nm) with least polydispersity index (PDI) (i.e., 0.193 ± 0.01). The sustained release (up to 24 h) of ginsenoside Rb1 (GRb1) is revealed by the dissolution study of PM. A significantly (p < 0.05) greater anti-oxidant (AO) potential of PM can well be perceived as of the diminution in the lipid peroxidase level in addition to the rise in the glutathione superoxide dismutase (SOD) in addition to catalase levels. It also showed a greater neuroprotective potential exhibiting significant (p < 0.05) augmentation in the nociceptive threshold together with the diminution in damage to nerves. A noteworthy enhancement in the relative BA (157.94%) of GRb1 through the PM formulation can well be seen in the PK studies. Conclusion: It is exhibited that the PM system is an optimistic and feasible strategy to enhance the delivery of GE for the effectual treatment of neuropathic pain. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ginseng" title="ginseng">ginseng</a>, <a href="https://publications.waset.org/abstracts/search?q=neuropathic" title=" neuropathic"> neuropathic</a>, <a href="https://publications.waset.org/abstracts/search?q=phytosome" title=" phytosome"> phytosome</a>, <a href="https://publications.waset.org/abstracts/search?q=pain" title=" pain"> pain</a> </p> <a href="https://publications.waset.org/abstracts/139025/delivery-of-ginseng-extract-containing-phytosome-loaded-microsphere-system-a-preclinical-approach-for-treatment-of-neuropathic-pain-in-rodent-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139025.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">187</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Self-Healing Hydrogel Triggered by Magnetic Microspheres to Control Glutathione Release for Cartilage Repair</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I-Yun%20Cheng">I-Yun Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Min-Yu%20Chiang"> Min-Yu Chiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Shwu-Jen%20Chang"> Shwu-Jen Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=San-Yuan%20Chen"> San-Yuan Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoarthritis (OA) is among the most challenging joint diseases, and as far as we know, there is currently no exact and effective cure for it because it has low self-repair ability due to lack of blood vessels and low cell density in articular cartilage. So far, there have been several methods developed to treat cartilage disorder. The most common method is to treat the high molecular weight of hyaluronic acid (HA) injection, but it will degrade after a period of time, so the patients need to inject HA repeatedly. In recent years, self-healing hydrogel has drawn considerable attention because it can recover its initial mechanical properties after damaged and further increase the lifetime of the hydrogel. Here, we aim to develop a self-healable composite hydrogel combined with magnetic microspheres to trigger glutathione(GSH) release for promoting cartilage repair. We use HA-cyclodextrin (CD) as host polymer and poly(acrylic acid)-ferrocene (pAA-Fc) as guest polymer to form the self-healable HA-pAA hydrogel by host and guest interaction where various graft amount of pAA-Fc (pAA:Fc= 1:2, 1:1.5, 1:1, 2:1, 4:1) was conducted to develop different mechanical strength hydrogel. The rheology analysis showed that the 4:1 of pAA-Fc has higher mechanical strength than other formulations. On the other hand, iron oxide nanoparticle, poly(lactic-co-glycolic acid) (PLGA) and polyethyleneimine (PEI) were used to synthesize porous magnetic microspheres via double emulsification water-in-oil-in-water (W/O/W) to increase GSH loading which acted as a reductant to control the hydrogel crosslink density and promote hydrogel self-healing. The results show that the porous magnetic microspheres can be loaded with 70% of GSH and sustained release about 50% of GSH after 24 hours. More importantly, the HA-pAA composite hydrogel can self-heal rapidly within 24 hours when suffering external force destruction by releasing GSH from the magnetic microspheres. Therefore, the developed the HA-pAA composite hydrogel combined with GSH-loaded magnetic microspheres can be in-vivo guided to damaged OA surface for inducing the cartilage repair by controlling the crosslinking of self-healing hydrogel via GSH release. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=articular%20cartilage" title="articular cartilage">articular cartilage</a>, <a href="https://publications.waset.org/abstracts/search?q=magnetic%20microsphere" title=" magnetic microsphere"> magnetic microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=osteoarthritis" title=" osteoarthritis"> osteoarthritis</a>, <a href="https://publications.waset.org/abstracts/search?q=self-healing%20hydrogel" title=" self-healing hydrogel"> self-healing hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/106078/self-healing-hydrogel-triggered-by-magnetic-microspheres-to-control-glutathione-release-for-cartilage-repair" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106078.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Everolimus Loaded Polyvinyl Alcohol Microspheres for Sustained Drug Delivery in the Treatment of Subependymal Giant Cell Astrocytoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lynn%20Louis">Lynn Louis</a>, <a href="https://publications.waset.org/abstracts/search?q=Bor%20Shin%20Chee"> Bor Shin Chee</a>, <a href="https://publications.waset.org/abstracts/search?q=Marion%20McAfee"> Marion McAfee</a>, <a href="https://publications.waset.org/abstracts/search?q=Michael%20Nugent"> Michael Nugent</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This article aims to develop a sustained release formulation of microspheres containing the mTOR inhibitor Everolimus (EVR) using Polyvinyl alcohol (PVA) to enhance the bioavailability of the drug and to overcome poor solubility characteristics of Everolimus. This paper builds on recent work in the manufacture of microspheres using the sessile droplet technique by freezing the polymer-drug solution by suspending the droplets into pre-cooled ethanol vials immersed in liquid nitrogen. The spheres were subjected to 6 freezing cycles and 3 freezing cycles with thawing to obtain proper geometry, prevent aggregation, and achieve physical cross-linking. The prepared microspheres were characterised for surface morphology by SEM, where a 3-D porous structure was observed. The in vitro release studies showed a 62.17% release over 12.5 days, indicating a sustained release due to good encapsulation. This result is comparatively much more than the 49.06% release achieved within 4 hours from the solvent cast Everolimus film as a control with no freeze-thaw cycles performed. The solvent cast films were made in this work for comparison. A prolonged release of Everolimus using a polymer-based drug delivery system is essential to reach optimal therapeutic concentrations in treating SEGA tumours without systemic exposure. These results suggest that the combination of PVA and Everolimus via a rheological synergism enhanced the bioavailability of the hydrophobic drug Everolimus. Physical-chemical characterisation using DSC and FTIR analysis showed compatibility of the drug with the polymer, and the stability of the drug was maintained owing to the high molecular weight of the PVA. The obtained results indicate that the developed PVA/EVR microsphere is highly suitable as a potential drug delivery system with improved bioavailability in treating Subependymal Giant cell astrocytoma (SEGA). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery%20system" title="drug delivery system">drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=everolimus" title=" everolimus"> everolimus</a>, <a href="https://publications.waset.org/abstracts/search?q=freeze-thaw%20cycles" title=" freeze-thaw cycles"> freeze-thaw cycles</a>, <a href="https://publications.waset.org/abstracts/search?q=polyvinyl%20alcohol" title=" polyvinyl alcohol"> polyvinyl alcohol</a> </p> <a href="https://publications.waset.org/abstracts/151445/everolimus-loaded-polyvinyl-alcohol-microspheres-for-sustained-drug-delivery-in-the-treatment-of-subependymal-giant-cell-astrocytoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/151445.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">127</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Optical Characterization of Transition Metal Ion Doped ZnO Microspheres Synthesized via Laser Ablation in Air</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Parvathy%20Anitha">Parvathy Anitha</a>, <a href="https://publications.waset.org/abstracts/search?q=Nilesh%20J.%20Vasa"> Nilesh J. Vasa</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Ramachandra%20Rao"> M. S. Ramachandra Rao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> ZnO is a semiconducting material with a direct wide band gap of 3.37 eV and a large exciton binding energy of 60 meV at room temperature. Microspheres with high sphericity and symmetry exhibit unique functionalities which makes them excellent omnidirectional optical resonators. Hence there is an advent interest in fabrication of single crystalline semiconductor microspheres especially magnetic ZnO microspheres, as ZnO is a promising material for semiconductor device applications. Also, ZnO is non-toxic and biocompatible, implying it is a potential material for biomedical applications. Room temperature Photoluminescence (PL) spectra of the fabricated ZnO microspheres were measured, at an excitation wavelength of 325 nm. The ultraviolet (UV) luminescence observed is attributed to the room-temperature free exciton related near-band-edge (NBE) emission in ZnO. Besides the NBE luminescence, weak and broad visible luminescence (~560nm) was also observed. This broad emission band in the visible range is associated with oxygen vacancies related to structural defects. In transition metal (TM) ion-doped ZnO, 3d levels emissions of TM ions will modify the inherent characteristic emissions of ZnO. A micron-sized ZnO crystal has generally a wurtzite structure with a natural hexagonal cross section, which will serve as a WGM (whispering gallery mode) lasing micro cavity due to its high refractive index (~2.2). But hexagonal cavities suffers more optical loss at their corners in comparison to spherical structures; hence spheres may be a better candidate to achieve effective light confinement. In our study, highly smooth spherical shaped micro particles with different diameters ranging from ~4 to 6 μm were grown on different substrates. SEM (Scanning Electron Microscopy) and AFM (Atomic Force Microscopy) images show the presence of uniform smooth surfaced spheres. Raman scattering measurements from the fabricated samples at 488 nm light excitation provide convincing supports for the wurtzite structure of the prepared ZnO microspheres. WGM lasing studies from TM-doped ZnO microparticles are in progress. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=laser%20ablation" title="laser ablation">laser ablation</a>, <a href="https://publications.waset.org/abstracts/search?q=microcavity" title=" microcavity"> microcavity</a>, <a href="https://publications.waset.org/abstracts/search?q=photoluminescence" title=" photoluminescence"> photoluminescence</a>, <a href="https://publications.waset.org/abstracts/search?q=ZnO%20microsphere" title=" ZnO microsphere"> ZnO microsphere</a> </p> <a href="https://publications.waset.org/abstracts/52451/optical-characterization-of-transition-metal-ion-doped-zno-microspheres-synthesized-via-laser-ablation-in-air" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52451.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">217</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Nanotechnology for Flame Retardancy of Thermoset Resins</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ewa%20Kicko%20Walczak">Ewa Kicko Walczak</a>, <a href="https://publications.waset.org/abstracts/search?q=Grazyna%20Rymarz"> Grazyna Rymarz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, nanotechnology has been successfully applied for flame retardancy of polymers, in particular for construction materials. The consumption of thermoset resins as a construction polymers materials is approximately over one million tone word wide. Excellent mechanical, relatively high heat and thermal stability of their type of polymers are proven for variety applications, e.g. transportation, electrical, electronic, building part industry. Above applications in addition to the strength and thermal properties also requires -referring to the legal regulation or recommendation - an adequate level of flammability of the materials. This publication present the evaluation was made of effectiveness of flame retardancy of halogen-free hybrid flame retardants(FR) as compounds nitric/phosphorus modifiers that act with nanofillers (nano carbons, organ modified montmorillonite, nano silica, microsphere) in relation to unsaturated polyester/epoxy resins and glass-reinforced on base this resins laminates(GRP) as a final products. The analysis of the fire properties provided proof of effective flame retardancy of the tested composites by defining oxygen indices values (LOI), with the use of thermogravimetric methods (TGA) and combustion head (CH). An analysis of the combustion process with Cone Calorimeter (CC) method included in the first place N/P units and nanofillers with the observed phenomenon of synergic action of compounds. The fine-plates, phase morphology and rheology of composites were assessed by SEM/ TEM analysis. Polymer-matrix glass reinforced laminates with modified resins meet LOI over 30%, reduced in a decrease by 70% HRR (according to CC analysis), positive description of the curves TGA and values CH; no adverse negative impact on mechanical properties. The main objective of our current project is to contribute to the general understanding of the flame retardants mechanism and to investigate the corresponding structure/properties relationships. We confirm that nanotechnology systems are successfully concept for commercialized forms for non-flammable GRP pipe, concrete composites, and flame retardant tunnels constructions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fire%20retardants" title="fire retardants">fire retardants</a>, <a href="https://publications.waset.org/abstracts/search?q=FR" title=" FR"> FR</a>, <a href="https://publications.waset.org/abstracts/search?q=halogen-free%20FR%20nanofillers" title=" halogen-free FR nanofillers"> halogen-free FR nanofillers</a>, <a href="https://publications.waset.org/abstracts/search?q=non-flammable%20pipe%2Fconcrete" title=" non-flammable pipe/concrete"> non-flammable pipe/concrete</a>, <a href="https://publications.waset.org/abstracts/search?q=thermoset%20resins" title=" thermoset resins"> thermoset resins</a> </p> <a href="https://publications.waset.org/abstracts/66582/nanotechnology-for-flame-retardancy-of-thermoset-resins" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66582.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">284</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Sustainable Pavements with Reflective and Photoluminescent Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.H.%20Mart%C3%ADnez">A.H. Martínez</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20L%C3%B3pez-Montero"> T. López-Montero</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Mir%C3%B3"> R. Miró</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Puig"> R. Puig</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Villar"> R. Villar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An alternative to mitigate the heat island effect is to pave streets and sidewalks with pavements that reflect incident solar energy, keeping their surface temperature lower than conventional pavements. The “Heat island mitigation to prevent global warming by designing sustainable pavements with reflective and photoluminescent properties (RELUM) Project” has been carried out with this intention in mind. Its objective has been to develop bituminous mixtures for urban pavements that help in the fight against global warming and climate change, while improving the quality of life of citizens. The technology employed has focused on the use of reflective pavements, using bituminous mixes made with synthetic bitumens and light pigments that provide high solar reflectance. In addition to this advantage, the light surface colour achieved with these mixes can improve visibility, especially at night. In parallel and following the latter approach, an appropriate type of treatment has also been developed on bituminous mixtures to make them capable of illuminating at night, giving rise to photoluminescent applications, which can reduce energy consumption and increase road safety due to improved night-time visibility. The work carried out consisted of designing different bituminous mixtures in which the nature of the aggregate was varied (porphyry, granite and limestone) and also the colour of the mixture, which was lightened by adding pigments (titanium dioxide and iron oxide). The reflectance of each of these mixtures was measured, as well as the temperatures recorded throughout the day, at different times of the year. The results obtained make it possible to propose bituminous mixtures whose characteristics can contribute to the reduction of urban heat islands. Among the most outstanding results is the mixture made with synthetic bitumen, white limestone aggregate and a small percentage of titanium dioxide, which would be the most suitable for urban surfaces without road traffic, given its high reflectance and the greater temperature reduction it offers. With this solution, a surface temperature reduction of 9.7°C is achieved at the beginning of the night in the summer season with the highest radiation. As for luminescent pavements, paints with different contents of strontium aluminate and glass microspheres have been applied to asphalt mixtures, and the luminance of all the applications designed has been measured by exciting them with electric bulbs that simulate the effect of sunlight. The results obtained at this stage confirm the ability of all the designed dosages to emit light for a certain time, varying according to the proportions used. Not only the effect of the strontium aluminate and microsphere content has been observed, but also the influence of the colour of the base on which the paint is applied; the lighter the base, the higher the luminance. Ongoing studies are focusing on the evaluation of the durability of the designed solutions in order to determine their lifetime. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heat%20island" title="heat island">heat island</a>, <a href="https://publications.waset.org/abstracts/search?q=luminescent%20paints" title=" luminescent paints"> luminescent paints</a>, <a href="https://publications.waset.org/abstracts/search?q=reflective%20pavement" title=" reflective pavement"> reflective pavement</a>, <a href="https://publications.waset.org/abstracts/search?q=temperature%20reduction" title=" temperature reduction"> temperature reduction</a> </p> <a href="https://publications.waset.org/abstracts/188899/sustainable-pavements-with-reflective-and-photoluminescent-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188899.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">30</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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