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Rheumatology

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id="breadcrumbs"> <a href="/web/20131123124045/http://www.healio.com/"> Healio</a> <span>&#8250;</span> <a href="/web/20131123124045/http://www.healio.com/rheumatology"> Rheumatology</a> </p> <!-- /breadcrumbs --> <!-- breaking news --> <div id="breaking-news" class="breaking-news"> <div id="layout_0_phmaincontent_1_divbreakingnewscontent" class="breakingnewscontent"> <h2> <a id="layout_0_phmaincontent_1_ctl00_hlTitle" href="/web/20131123124045/http://www.healio.com/rheumatology/rheumatoid-arthritis/news/online/{65f23259-99c1-4e96-8808-e1cab1f390ce}/ra-patients-improved-symptoms-with-sarilumabmtx-treatment">RA patients improved symptoms with sarilumab/MTX treatment</a> </h2> <ul class="meta-info"> <li> November 22, 2013</li> </ul> <!-- figure --> <!-- /figure --> <p> <p>Adults with active rheumatoid arthritis who had inadequate response to methotrexate therapy displayed improved signs and symptoms when sarilumab was combined with methotrexate, according to phase 3 study results announced by Sanofi and Regeneron Pharmaceuticals.</p> <p>Sarilumab, an experimental agent under clinical development, is the first fully human monoclonal antibody directed against the interleukin-6 receptor, according to a news release. It is delivered subcutaneously and blocks the binding of IL-6 to its receptor, interrupting the resultant cytokine-mediated inflammatory signaling.</p> .<a id="layout_0_phmaincontent_1_ctl00_hlFullStory" class="jump-link" href="/web/20131123124045/http://www.healio.com/rheumatology/rheumatoid-arthritis/news/online/{65f23259-99c1-4e96-8808-e1cab1f390ce}/ra-patients-improved-symptoms-with-sarilumabmtx-treatment">Full Story <span>禄</span></a> </p> <script type="text/javascript"> setTimeout(function(){ $j(".breakingnewscontent").load("/webservices/utility.asmx/getBreakingNewsContent",{paramlist:'strings:{F0F1C5C0-7948-4AB6-A976-CB5A0D9A5AD9}|{9F65FD41-483D-4658-B8A7-E8B5D234CA83}|{C8423EC6-E560-4329-A37F-B3CA5ED13F0D}|{3A527268-F906-4712-8EA4-3D61A946BEF2}|{5B500083-DDEF-4109-A5C1-3A6F7DB24BD1}|{073D6761-DE60-4A2F-B3F6-C6D8F705222D}|{349DB4A1-38E2-4A55-9077-5C079A63A9EC}|{55BAFCBC-AEF3-466A-924E-35DA7C2BBE02}|{F73CEAB7-6C4A-4A5D-B5E2-C18BD501A06C}|{7B3F3641-FCC4-4751-95D3-950A8880E443}|{7B88647F-240F-4B05-B0F2-08166AC4AF02}|{ED77D737-BD16-48FE-BF58-B6D490F07CD5}|{EC1E6688-0DFB-4C9D-9737-2612187E8525}|{2C3AA5F0-AA5B-4993-BAAD-17FAEA0AD31A}|{67C759CB-AE25-4093-8A51-87FA52521FC2}|{5AF278D4-79B7-4EB2-9928-BB1F7331156A},autorefresh:true'}); 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It鈥檚 FREE and only takes one minute. <a id="layout_0_phmaincontent_2_RegisterNow" rel="nofollow" href="/web/20131123124045/http://www.healio.com/footer/account-information/login">Register now!</a></p> </div> <!-- video content --> <div id="video-channel"> <iframe src="https://web.archive.org/web/20131123124045if_/http://video.healio.com/embed/player/6MJ3TM0VSWFV68PQ" width="488" height="240" frameborder="0" marginheight="0" marginwidth="0" scrolling="no" allowtransparency="true"></iframe> </div> <!-- /video content --> <!-- silo content --> <div id="silo-content"> <div class="module-box-alt left"> <ul> <li class="title">Meeting News Coverage</li> <li class="img"><a href="https://web.archive.org/web/20131123124045/http://www.healio.com/rheumatology/meetings/meeting-news-coverage"> <img src="/web/20131123124045im_/http://www.healio.com/~/media/Images/silos/Ophthalmology/Meeting Coverage stock1.jpg" alt="Meeting Coverage" width="90" height="120"/></a></li> <li><strong><a href="https://web.archive.org/web/20131123124045/http://www.healio.com/rheumatology/meetings/meeting-news-coverage"> American College of Rheumatology Annual Meeting</a></strong></li> <li class="meta-info"> Read coverage of research presented at this year's annual meeting in San Diego.</li> </ul> <a class="jump-link" href="https://web.archive.org/web/20131123124045/http://www.healio.com/rheumatology/meetings/meeting-news-coverage">More <span>禄</span></a> </div> <div class="module-box-alt right"> <ul> <li class="title">Rheumatoid Arthritis</li> <li class="img"><a href="/web/20131123124045/http://www.healio.com/rheumatology/rheumatoid-arthritis/news/online/{da521798-41c2-48b3-a964-d352090f00de}/coronary-artery-calcium-did-not-significantly-differ-between-ra-patients-controls"> <img src="/web/20131123124045im_/http://www.healio.com/~/media/Images/silos/Rheumatology/2012/11_November/Petri_Michelle_70x90 w 1 px border.jpg" alt="Michelle Petri MD" width="70" height="90"/></a></li> <li><strong><a href="/web/20131123124045/http://www.healio.com/rheumatology/rheumatoid-arthritis/news/online/{da521798-41c2-48b3-a964-d352090f00de}/coronary-artery-calcium-did-not-significantly-differ-between-ra-patients-controls"> Coronary artery calcium</a></strong></li> <li class="meta-info"> Incidence of newly detected coronary artery calcium did not differ significantly between RA patients and controls, according to Michelle Petri, MD, MPH.</li> </ul> <a class="jump-link" target="_blank" href="/web/20131123124045/http://www.healio.com/rheumatology/rheumatoid-arthritis/news/online/{da521798-41c2-48b3-a964-d352090f00de}/coronary-artery-calcium-did-not-significantly-differ-between-ra-patients-controls">More <span>禄</span></a> </div> <div class="module-box-alt left"> <ul> <li class="title">Healio Minute, November 22, 2013</li> <li class="img"><a href="/web/20131123124045/http://www.healio.com/news/online/{e7f7c6c0-a662-4a43-a543-f29a962b3ddb}/healio-minute-friday-nov-22-2013-edition-non-cigarette-nicotine-draws-young-users-obesity-dangers-may-trump-metabolic-status-ehrs-could-help-physicians-help-the-uninsured"> <img src="/web/20131123124045im_/http://www.healio.com/~/media/Images/silos/Healio/121631_Healio Minute opt2_70px.jpg" alt="Healio Minute logo" width="70" height="90"/></a></li> <li><strong><a href="/web/20131123124045/http://www.healio.com/news/online/{e7f7c6c0-a662-4a43-a543-f29a962b3ddb}/healio-minute-friday-nov-22-2013-edition-non-cigarette-nicotine-draws-young-users-obesity-dangers-may-trump-metabolic-status-ehrs-could-help-physicians-help-the-uninsured"> Nicotine, obesity, EHRs</a></strong></li> <li class="meta-info"> Non-cigarette nicotine draws youth, obesity dangers may trump metabolic status, EHRs could help physicians help the uninsured.</li> </ul> <a class="jump-link" target="_blank" href="/web/20131123124045/http://www.healio.com/news/online/{e7f7c6c0-a662-4a43-a543-f29a962b3ddb}/healio-minute-friday-nov-22-2013-edition-non-cigarette-nicotine-draws-young-users-obesity-dangers-may-trump-metabolic-status-ehrs-could-help-physicians-help-the-uninsured">More <span>禄</span></a> </div> <div class="module-box-alt right"> <ul> <li class="title">Health Care Legislative and Regulatory Update</li> <li class="img"><a href="/web/20131123124045/http://www.healio.com/cardiology/practice-management/news/online/{fbc577eb-45dc-4f2c-99ab-37eb0520dc70}/new-bill-mandates-national-requirements-for-drug-compounding-distribution"> <img src="/web/20131123124045im_/http://www.healio.com/~/media/Images/silos/Arnold and Porter silo/KracovDanielA2013SILO.jpg" alt="daniel kracov 2013 silo" width="70" height="90"/></a></li> <li><strong><a href="/web/20131123124045/http://www.healio.com/cardiology/practice-management/news/online/{fbc577eb-45dc-4f2c-99ab-37eb0520dc70}/new-bill-mandates-national-requirements-for-drug-compounding-distribution"> Compounding realities</a></strong></li> <li class="meta-info"> Daniel A. Kracov of Arnold &amp; Porter LLP examines new requirements for drug compounding and distribution.</li> </ul> <a class="jump-link" href="/web/20131123124045/http://www.healio.com/cardiology/practice-management/news/online/{fbc577eb-45dc-4f2c-99ab-37eb0520dc70}/new-bill-mandates-national-requirements-for-drug-compounding-distribution">More <span>禄</span></a> </div> </div> <!-- /silo content --> </div> <!-- /maincontent --> <!-- main-content --> <!-- googleoff: index --> <div id="sidebar"> <!-- googleoff: index --> <!-- edlab box --> <div id="edlab" class="sidebar-box"> <h5 class="rheumatology"> <a href="/web/20131123124045/http://www.healio.com/rheumatology/education-lab" class="edu-top-link">Education Lab</a></h5> <ul> <li class="img"><a rel="EdLab Callout" href="/web/20131123124045/http://www.healio.com/rheumatology/education-lab/2013/05_may/advances-in-chronic-oa-management-vol-2-number-1" 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