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url(https://somalogic.com/wp-content/uploads/2022/07/Hero_Texture-1-scaled.jpeg);height: 600px;" title="Splash of color"> <div class="container"> <div class="grid"> <div class="cell-md-9"> <p class="breadcrumbs"><a href="/">Home</a> / Platform / Features / <span class="blue">Specificity</span></p> <h1>The ability to profile thousands of proteins in a single assay begins with exquisite specificity</h1> </div> </div> </div> </div><div class="wrap white align-center" id="wrap_0" title=""> <div class="container"> <div class="grid"><div id="specificityVideo" class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mb-60"><h2>See the <em class="blue">exquisite specificity</em> of the SomaScan® Assay</h2> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_6rwottgw3k dnt=1 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/6rwottgw3k/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" aria-hidden="true" onload="this.parentNode.style.opacity=1;" /></div></div></div></div></div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><hr /> </div> </div><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pr-40"><script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_idlmhbefxw dnt=1 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/idlmhbefxw/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" aria-hidden="true" onload="this.parentNode.style.opacity=1;" /></div></div></div></div></div> </div><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><blockquote class="transparent"><p>The SomaScan [Assay] also has a two-step approach to specificity that is sometimes forgotten by non-experts…between these two steps, the assay turns out to be quite highly specific.”<br /> <span class="author"><strong>Peter Ganz, MD </strong>Director of the Center of Excellence in Vascular Research<br /> Zuckerberg San Francisco General Hospital</span></p> <p>Professor of Medicine,<br /> University of California in San Francisco</p></blockquote> </div> </div></div> </div> </div><div class="wrap grey align-center" id="wrap_1" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-10 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class=""><h2 class="a-center">Why <em class="blue">modified aptamers</em>?</h2> <p class="a-center">The SomaScan Platform uses unique modified aptamers — short sequences of DNA — as protein affinity reagents. Our proprietary SOMAmer® (Slow Off-Rate Modified Aptamer) Reagents are chemically modified aptamers to achieve specificity and sensitivity.</p> <h3>Shape specificity</h3> <p>By using uniquely modified DNA with hydrophobic functional groups, our SOMAmer Reagents achieve a greater degree of shape matching, enabling discernment between nearly identical proteins.</p> <h3>Slow off-rates</h3> <p>SOMAmer Reagents are selected for slow off-rates when correctly bound to their intended target to ensure that correct proteins remain preferentially bound during rigorous washing.</p> <h3>Polyanionic competition</h3> <p>Polyanionic competitors are used to universally prevent rebinding of transient, non-specific interactions. There is no such universal competitor for antibodies.</p> <p> </p> <p> </p> </div> </div><div class="text-block cell-md-5 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class="a-center pr-40"><h3>X-ray crystal structure of a<br /> SOMAmer Reagent bound<br /> to PDGF-BB</h3> <p>Modifications to the bases are shown in purple, and the DNA backbone and unmodified bases are in teal.</p> <p><img decoding="async" class="alignnone size-full wp-image-372" src="https://somalogic.com/wp-content/uploads/2022/06/Specificity-First-Image.jpg" alt="Zoom in of magnified protein" width="100%" srcset="https://somalogic.com/wp-content/uploads/2022/06/Specificity-First-Image.jpg 848w, https://somalogic.com/wp-content/uploads/2022/06/Specificity-First-Image-300x204.jpg 300w, https://somalogic.com/wp-content/uploads/2022/06/Specificity-First-Image-768x522.jpg 768w" sizes="(max-width: 848px) 100vw, 848px" /></p> </div> </div><div class="text-block cell-md-5 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center pl-40"><h3>Typical dissociation<br /> for a<br /> SOMAmer Reagent</h3> <p>This graph shows the typical dissociation for a SOMAmer Reagent over time, in this case targeting C3.</p> <p><img loading="lazy" decoding="async" class="aligncenter size-full wp-image-7600" src="https://somalogic.com/wp-content/uploads/2024/03/typical_dissociation_for_a_SOMAmer_Reagent_v1_2022.svg" alt="Typical Dissociation for a SOMAmer Reagent chart" width="424" height="288" /></p> </div> </div><div class="text-block cell-md-4 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class="mt-60"><p><img loading="lazy" decoding="async" class="alignnone wp-image-5543" src="https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb-259x300.png" alt="Thumbnail of SomaLogic Apatmers and Antibodies Comparison Sheet" width="600" height="696" srcset="https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb-259x300.png 259w, https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb-882x1024.png 882w, https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb-768x891.png 768w, https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb-1324x1536.png 1324w, https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb-215x250.png 215w, https://somalogic.com/wp-content/uploads/2023/09/comparisonSheetThumb.png 1545w" sizes="auto, (max-width: 600px) 100vw, 600px" /></p> </div> </div><div class="text-block cell-md-6 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="pl-40 mt-60"><h2>How do <em class="blue">aptamers</em><br /> compare to <em class="blue">antibodies?</em></h2> <p>Traditionally, affinity-based platforms have used antibodies as reagents. But SomaLogic pioneered the use of aptamers more than 20 years ago to address the challenges researchers face in using antibodies, including performance and natural variability in structure. Download a quick comparison <a href="https://dam.somalogic.com/m/6644677b75a91b45/original/SL00000855_Rev_1_2023_12_Aptamer-vs-Antibody-Comparison-Sheet.pdf" target="_blank" rel="noopener">here</a>.</p> </div> </div></div> </div> </div><div class="wrap white " id="orthogonal-validation" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="mb-60 a-center"><h2><em class="blue">Primary validation</em> and <em class="blue">orthogonal confirmation</em> of SOMAmer Reagent specificity</h2> <p>SOMAmer Reagents are protein-binding affinity reagents targeted to a specific protein.</p> </div> </div><div class="text-block cell-md-5 cell-offset-md-1 cell-sm-12 cell-offset-sm-0" > <div class=""><div class="transparent"> <p><strong>Primary validation</strong> of <em class="blue">all</em> SOMAmer Reagents</p> <ul> <li>Determination of the equilibrium binding affinity dissociation constant (K<sub>D</sub>)</li> <li>Pulldown assay of cognate protein in buffer using the SOMAmer Reagent</li> <li>Demonstration of buffer dose response in the SomaScan Assay</li> <li>Estimation of endogenous signal in plasma</li> </ul> </div> </div> </div><div class="text-block cell-md-5 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><div class="transparent"> <p><strong>Orthogonal confirmation</strong></p> <ul> <li>At least 66% of SOMAmer Reagents have at least one additional source of orthogonal confirmation</li> <li>Specificity of the SOMAmer Reagent for its cognate protein has been confirmed by orthogonal methods, such as mass spectroscopy and ELISA, for nearly 6,000 reagents</li> </ul> </div> </div> </div><div class="text-block cell-md-12 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center mb-60 mt-60"><h2>SOMAmer Reagent <em class="blue">affinity and specificity</em><br /> demonstrated by multiple methods</h2> <p>SomaLogic provides the largest number of protein measurements and the greatest number of orthogonally confirmed protein reagents in the proteomics industry.</p> </div> </div><div class="text-block cell-md-8 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center"><p><img loading="lazy" decoding="async" class="alignnone wp-image-8773" src="https://somalogic.com/wp-content/uploads/2024/09/11K-Donut-art_8-21-2024-1024x781.png" alt="SomaScan 11K Assay Orthogonal Validation Chart" width="500" height="381" srcset="https://somalogic.com/wp-content/uploads/2024/09/11K-Donut-art_8-21-2024-1024x781.png 1024w, https://somalogic.com/wp-content/uploads/2024/09/11K-Donut-art_8-21-2024-300x229.png 300w, https://somalogic.com/wp-content/uploads/2024/09/11K-Donut-art_8-21-2024-768x585.png 768w, https://somalogic.com/wp-content/uploads/2024/09/11K-Donut-art_8-21-2024-1536x1171.png 1536w, https://somalogic.com/wp-content/uploads/2024/09/11K-Donut-art_8-21-2024-2048x1561.png 2048w" sizes="auto, (max-width: 500px) 100vw, 500px" /></p> </div> </div><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class=""><div class="grey-block"> <h3 style="text-align: center">Primary validation of 11,000<br /> SOMAmer Reagents</h3> <ul style="text-align: left"> <li>Determination of equilibrium binding affinity dissociation constant (K<sub>D</sub>)</li> <li>Pulldown assay of cognate protein from buffer</li> <li>Demonstration of buffer dose response in the SomaScan Assay</li> <li>Estimation of endogenous cognate protein signals in plasma</li> </ul> <p style="text-align: left"><strong>Over 6,000</strong> SOMAmer Reagents have at least one additional form of orthogonal confirmation.</p> <p style="text-align: left"><strong>Approximately 3,000</strong> SOMAmer Reagents have undergone two or more forms of orthogonal confirmation.</p> </div> </div> </div></div> </div> </div><div class="wrap grey " id="wrap_3" title=""> <div class="container"> <div class="grid"><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center grey-block oEmbed-reverse-order-container same-height="height1""><h3 class="oEmbed-container-bottom-item">What <em class="blue">evidence</em> do we have that SOMAmer Reagents are specific?</h3> <script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_zmsc2wu1gn dnt=1 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/zmsc2wu1gn/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" aria-hidden="true" onload="this.parentNode.style.opacity=1;" /></div></div></div></div></div> </div><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center grey-block oEmbed-reverse-order-container same-height="height1""><h3 class="oEmbed-container-bottom-item">What are the <em class="blue">advantages</em> of shape-specific proteomics?</h3> <script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_r0kyfpbhku dnt=1 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img src="https://fast.wistia.com/embed/medias/r0kyfpbhku/swatch" style="filter:blur(5px);height:100%;object-fit:contain;width:100%;" alt="" aria-hidden="true" onload="this.parentNode.style.opacity=1;" /></div></div></div></div></div> </div><div class="text-block cell-md-4 cell-offset-md-0 cell-sm-12 cell-offset-sm-0" > <div class="a-center grey-block oEmbed-reverse-order-container same-height="height1""><h3 class="oEmbed-container-bottom-item">How does exquisite specificity <em class="blue">enable</em> thousands of protein measurements?</h3> <script src="https://fast.wistia.com/assets/external/E-v1.js" async></script><div class="wistia_responsive_padding" style="padding:56.25% 0 0 0;position:relative;"><div class="wistia_responsive_wrapper" style="height:100%;left:0;position:absolute;top:0;width:100%;"><div class="wistia_embed wistia_async_skv5dkjwb5 dnt=1 seo=false videoFoam=true" style="height:100%;position:relative;width:100%"><div class="wistia_swatch" style="height:100%;left:0;opacity:0;overflow:hidden;position:absolute;top:0;transition:opacity 200ms;width:100%;"><img 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