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class="profile__content"> <h3 class="profile__name" itemprop="name"> Luk Vandenberghe, PhD</h3> <p class="profile__title" itemprop="jobTitle">Associate Professor of Ophthalmology, Harvard Medical School </br> Grousbeck Family Chair in Gene Therapy and Director of the Grousbeck Gene Therapy Center, Mass Eye and Ear</p> </div> <p class="profile__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/luk_vandenberghe2_advances.png, /assets/images/contributors/luk_vandenberghe2_advances_2x.png 2x" src="/assets/images/contributors/luk_vandenberghe2_advances.png"> </p> </div> </div> </aside> <div class="layout-columns__main -padding--vertical -padding--horizontal" dcrname ="iwDCR0_041029"> <div class="layout-columns__main__content"> <h2 class="heading-h4">Posts by Luk Vandenberghe, PhD</h2> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/research-and-innovation/article-external.aspx?id=1100" itemprop="url"> Developing a Gene-based Vaccine Candidate for COVID-19</a> </h3> <p itemprop="description"> <p>Researchers from Massachusetts Eye and Ear and Massachusetts General Hospital are working together to expedite the development of a unique, gene-based vaccine candidate against COVID-19.</p></p> <p class="content-tease__related"> <a href="/ophthalmology/specialty.aspx?id=1014" itemprop="relatedLink">Ophthalmology</a>, <a href="/research-and-innovation/specialty.aspx?id=1011" itemprop="relatedLink">Research and Innovation</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2020-05-08" itemprop="datePublished">May 8, 2020</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/neuro/journal.aspx?id=1312" itemprop="url"> Review: Direct Gene Transfer to the Nervous System Now a Clinical Reality</a> </h3> <p itemprop="description"> <p>After decades of development, adeno-associated virus gene transfer is showing promise for permanent or long-lasting correction of neurologic disorders.</p></p> <p class="content-tease__related"> <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/ophthalmology/specialty.aspx?id=1014" itemprop="relatedLink">Ophthalmology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-06-25" itemprop="datePublished">June 25, 2019</time> </p> </div> </li> </ul> </div> </div> </section> <section class="-padding--vertical -padding--horizontal"> <div class="content-container -width--medium -centered"> <h2>Biography</h2> <p> Luk H. Vandenberghe, PhD, is an associate professor at Harvard Medical School and associate member of the Broad Institute of Harvard and MIT. He directs the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear Infirmary in Boston, USA, a part of the the Ocular Genomics Institute, a bench to bedside research program to study, diagnose and develop treatments for diseases of the eye. </ br> He received a degree in cellular and genetic engineering from the University of Leuven, Belgium. His previous work led to the discovery of novel AAV serotypes such as AAV9, novel insights into AAV structure-function and vector immunobiology. His laboratory aims to gain a deeper understanding of mechanisms of gene transfer, to develop technologies to overcome hurdles to gene therapy clinical applications and to translate specific gene therapy programs in vision, hearing and other fields. Recent studies leverage structural and evolutionary information on AAV as a starting point for the rational design of synthetic viral vector systems, a first generation of which is referred to as AncAAVs which are now progressing to the clinic for a number of indications. Dr. Vandenberghe previously co-founded GenSight Biologics and Akouos. He also is a founder, board member and advisor to Odylia Therapeutics, a non-profit catalyzing translation for gene therapies within the challenging field of ultra-rare disorders. Dr. Vandenberghe has over 50 peer reviewed publication and more than a dozen licensed patents, mostly related to gene therapy methods, technologies and applications.</p> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block .specialty-block__image { /* 540px */ background-image: url(/assets/raw/specialty-block/ophth-specialty-page-image2400.jpg); } only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-moz-min-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) { #specialty-block .specialty-block__image { /* 1080 width */ background-image: url(/assets/raw/specialty-block/opth-specialty-page-image1200.jpg); } } /* </style> <span class="specialty-block__image"></span> <div class="specialty-block"> <h2 class="section-heading">Mass Eye and Ear/Mass General Ophthalmology</h2> An international center for ophthalmology treatment and research, Mass Eye and Ear/Massachusetts General Hospital is the primary teaching hospital of Harvard Medical School鈥檚 Department of Ophthalmology, and is consistently recognized as one of the nation鈥檚 top hospitals for eye care. 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Miller, MD, the department provides seamless access to the most innovative care available anywhere in the world. <div class="specialty-block__meta"> <div class="specialty-block__links"> <h3 class="specialty-block__links__heading">Related Links</h3> <ul> <li><a href="https://www.masseyeandear.org/ophthalmology">Department of Ophthalmology</a></li> <li><a href="https://www.masseyeandear.org/research/ophthalmology">Ophthalmology Research</a></li> <li><a href="https://eye.hms.harvard.edu/">Harvard Ophthalmology</a></li> </ul> </div> <div class="specialty-block__logos"> <ul> <li><a href="https://www.masseyeandear.org/"><img alt="Mass Eye and Ear" src="/assets/raw/specialty-block/MEE-Logo-2021-3.png"></a></li> </ul> </div> </div> </div> </div> <div class="-padding--horizontal -padding--vertical -background--white"> <style> #email-signup { /* 540px */ background-image: url(/assets/raw/email-signup/cardiovascular-sub-callout.jpg); } only screen and (-webkit-min-device-pixel-ratio: 2), only 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