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The Science | NorthStar Medical Radioisotopes, LLC

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and serious diseases. NorthStar is routinely producing Cu-67 poised to be one of the first commercial-scale producers of Ac-225. Both are used to deliver precise therapeutic doses of radiation to destroy cancer cells in patients while sparing healthy tissue.</p> </div> </div> </div> </section> <section class="r7_row_multicolumns py-tall-b " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="p-5 bg-white-fade "> <div class="row align-items-start "> <div class="col-12 "> <h2 class="title mb-4 dk-blue"> HOW DOES Radiopharmaceutical<br>THERAPY <span>WORK?</span> </h2> <!-- LINK LIST --> </div> <div class="col-md-3 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/stage-1-med-02.png" class="w-75 img-fluid mb-4" alt="" /> </div> <div class="copy mb-4 mb-md-0"> <p>Radiopharmaceuticals suited for therapeutic purposes are those that strongly bind to the tumor.</p> </div> <!-- LINK LIST --> </div> <div class="col-md-3 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/stage-2-med-02.png" class="w-75 img-fluid mb-4" alt="" /> </div> <div class="copy mb-4 mb-md-0"> <p>They transport targeted doses of radiation directly to the tumor and its metastases, thereby sparing normal healthy tissue.</p> </div> <!-- LINK LIST --> </div> <div class="col-md-3 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/stage-3-med-02.png" class="w-75 img-fluid mb-4" alt="" /> </div> <div class="copy mb-4 mb-md-0"> <p>The carrier molecule type, such as antigens or receptors, is determined by its affinity to the tumor鈥檚 structure.</p> </div> <!-- LINK LIST --> </div> <div class="col-md-3 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/01/rn-diagram-4.png" class="w-75 img-fluid mb-4" alt="" /> </div> <div class="copy mb-4 mb-md-0"> <p>The ionizing radiation emitted by a radionuclide linked to the carrier, kills cancer cells by damaging their DNA, causing the tumors to shrink.</p> </div> <!-- LINK LIST --> </div> </div> <div class="row py-normal-t align-items-start "> <div class="col-12 mb-3 text-center"> <h2 class="title mb-4 dk-blue"> An IDEAL RADIOPHARMACEUTICAL<br><span>FOR THERAPEUTIC PURPOSES SHOULD:</span> </h2> <!-- LINK LIST --> </div> </div> <div class="row py-normal-b align-items-start flex-row-reverse"> <div class="col-md-9 "> <div class="copy mb-4 mb-md-0"> <div class="circle-numbers"> <div class="cn-row d-flex w-100"> <div class="group d-flex align-items-center"> <div class="c-number bg-dk-blue">1</div> <div class="c-desc">Reach all malignant tumor cells wherever they are localized</div> </div> <div class="group d-flex align-items-center"> <div class="c-number bg-blue">2</div> <div class="c-desc">Act exclusively in the cells of the malignant tumors</div> </div> </div> <div class="cn-row d-flex w-100"> <div class="group d-flex align-items-center"> <div class="c-number bg-teal">3</div> <div class="c-desc">Destroy malignant tumors cells with great efficiency</div> </div> <div class="group d-flex align-items-center"> <div class="c-number bg-xlt-green">4</div> <div class="c-desc">Deliver targeted radiation with high specificity, sparing healthy tissue</div> </div> </div> </div> </div> <!-- LINK LIST --> </div> <div class="col-md-3 "> <div class="row align-items-center"> <div class="col-5"> <a href="https://www.northstarnm.com/wp-content/uploads/2024/05/RPT-Backgrounder-March-2024.pdf" target="_blank"><img src="https://www.northstarnm.com/wp-content/uploads/2023/02/icon-pdf-teal.svg" class="w-100 img-fluid" alt="" /></a> </div> <div class="col-7"> <a href="https://www.northstarnm.com/wp-content/uploads/2024/05/RPT-Backgrounder-March-2024.pdf" target="_blank"> <div class="download_title"> <span class="teal">VIEW OUR</span> </div> <div class="download_desc dk-blue"> <span class="teal">Therapeutics<br>Backgrounder</span> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg bg-md-blue" style="background-color: #213083"> <div class="section-content "> <section class="r7_row_multicolumns py-normal " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="p-5 bg-bright-blue "> <div class="row align-items-start "> <div class="col-12 white"> <h2 class="title mb-4 "> THERAPEUTIC<br>RADIOPHARMACEUTICALS </h2> <!-- LINK LIST --> </div> <div class="col-md-6 "> <div class="pre-title mb-3 bright-green"> THERAPEUTIC RADIOPHARMACEUTICALS ARE COMPRISED OF A THERAPEUTIC RADIOISOTOPE AND A TARGETING MOLECULAR CARRIER THAT DELIVERS THE RADIOACTIVE DRUG SELECTIVELY TO CANCER CELLS, LEAVING HEALTHY CELLS INTACT. </div> <div class="copy mb-4 mb-md-0"> <p>Radioisotopes that decay by beta-particle (negatively charged electrons) or alpha-particle (helium nuclei) emissions are selected for these radiotherapeutics as they can deliver lethal radiation to tumor sites during their radioactive decay. The molecular carriers, such as monoclonal antibodies or peptides, target a specific site on a tumor cell and are designed for high tumor uptake. The radioisotopes are bound to the carrier molecules with a chemical linker to ensure the radionuclide remains attached to the molecule in the bloodstream and is carried to the tumor site to deliver their therapeutic dose. This graphic demonstrates this process.</p> </div> <!-- LINK LIST --> </div> <div class="col-md-6 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/01/thx-rad.png" class="w-100 img-fluid mb-4" alt="" /> </div> <!-- LINK LIST --> </div> </div> </div> </div> </div> </div> </section> <section class="r14_text_over_image py-normal-t py-tall-b"> <div class="container"> <div class="r14-layout"> <div class="r14-image"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/reactor1.jpg" alt="" class="img-fluid w-100" /> </div> <div class="r14-text-box bg-green p-4"> <div class="r14-title"> <h2 class="title mb-4 white"> GREENING<br><span>CANCER THERAPY</span> </h2> </div> <div class="r14-content white"> <p>NorthStar is already at the forefront of using environmentally preferred technologies to produce radioisotopes. Our advanced processes using electron accelerators produce far less problematic, long-lived waste and radioactive byproducts requiring highly sophisticated trans-uranial storage methods.</p> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg bg-bright-blue" > <div class="section-content "> <section class="r7_row_multicolumns py-0 footer-cta" > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="row py-short align-items-center "> <div class="col-md-4 "> <h2 class="title mb-4 "> CANCER THERAPY<br><span>REIMAGINED&trade;</span> </h2> <!-- LINK LIST --> </div> <div class="col-md-2 "> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/02/bubble-family1.png" class="max-width-mobile w-100 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <p>Important clinical studies are underway using Actinium-225 and Copper-67 in patients with various types of cancers such as prostate, lung, breast, colon, melanoma, lymphoma and neuroendocrine. 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