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src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F0e68d9ede29b679c285d53904f03101d53a0d1d9-800x776.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">November 14th 2024</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/studies-highlight-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-mpns">Studies Highlight Prognostic Value of Neutrophil-to-Lymphocyte Ratio in MPNs</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/mary-caffrey"><i>Mary Caffrey</i></a></span></div></div><a href="/view/studies-highlight-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-mpns"><a href="/view/studies-highlight-prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-mpns"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">The key driver in both sets of findings is the relationship between neutrophils and inflammation.</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/lower-pharmacy-costs-give-ruxolitinib-edge-for-patients-with-mf-and-anemia"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" 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text-gray-500 text-left"><i class="jsx-1434825611">March 1st 2024</i></span><div class="jsx-1434825611 w-full h-fit mb-4"><p class="jsx-1434825611 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Dr Jennifer Vaughn: Patients With MPN, MDS Should Discuss Long-Term Priorities Upfront</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/update-ruxolitinib-beats-best-available-therapy-in-treating-polycythemia-vera"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/319d0e45ca554b625bc11c5362dfae95b694d3f3-352x143.jpg?fit=crop&auto=format" alt="Jakafi | Image: Novartis" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/update-ruxolitinib-beats-best-available-therapy-in-treating-polycythemia-vera">Update: Ruxolitinib Beats Best Available Therapy in Treating Polycythemia Vera</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/update-ruxolitinib-beats-best-available-therapy-in-treating-polycythemia-vera"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Investigators added more data to an analysis first published in 2020 and got the same result: ruxolitinib beats other treatments for polycythemia vera.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-for-mpn-reflect-new-drugs-focus-on-clinical-trials"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/5f3d680e887a8b5f2cef8317d34733e970b6c44c-1200x675.jpg?fit=crop&auto=format" alt="Aaron Gerds, MS, MS | Image credit: Cleveland Clinic" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-for-mpn-reflect-new-drugs-focus-on-clinical-trials">NCCN Guidelines for MPN Reflect New Drugs, Focus on Clinical Trials</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/interview-by-mary-caffrey">Interview by Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-for-mpn-reflect-new-drugs-focus-on-clinical-trials"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An August 2024 update to the National Comprehensive Cancer Network (NCCN) clinical practice guidelines for treatment of myeloproliferative neoplasms (MPN) calls puts a priority on clinical trials, even preferring them to FDA-approved therapies in some cases. Aaron Gerds, MD, MS, of Cleveland Clinic Taussig Cancer Institute discusses the updates and what's in the pipeline for MPN treatment. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/korean-study-finds-doac-use-seems-effective-in-patients-with-mpns"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a0fa8883733c2c53aa4b3ac6b74b1be7b1bf7a65-1280x850.jpg?fit=crop&auto=format" alt="Rivaroxaban | Image: Janssen" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/korean-study-finds-doac-use-seems-effective-in-patients-with-mpns">Korean Study Finds DOAC Use “Seems Effective” in Patients With MPNs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/korean-study-finds-doac-use-seems-effective-in-patients-with-mpns"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A study based on a decade's worth of Korean insurance data found that use of direct oral anticoagulants (DOACs) to address atrial fibrillation and venous thromboembolism in patients with myeloproliferative neoplasms (MPNs) is effective, with acceptable bleeding risk.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/can-vaccines-be-developed-for-mpns-study-examines-the-challenges"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f119888e4efe0d8f08b83c66e8b4c7eed33e9859-1000x748.jpg?fit=crop&auto=format" alt="Can Vaccines Be Developed for MPNs? Study Examines the Challenges" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/can-vaccines-be-developed-for-mpns-study-examines-the-challenges">Can Vaccines Be Developed for MPNs? Study Examines the Challenges</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/can-vaccines-be-developed-for-mpns-study-examines-the-challenges"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers from Bulgaria conduct an analysis of the potential for therapeutic vaccines in by comparing testing results for patients from their country with an international data set.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/review-explores-cardiovascular-risk-in-certain-patients-with-mpns"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b34bae4461d4417a03d1c498670fd3e1024fc476-278x208.jpg?fit=crop&auto=format" alt="Bone marrow from patient with PMF " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/review-explores-cardiovascular-risk-in-certain-patients-with-mpns">Review Explores Cardiovascular Risk in Certain Patients With MPNs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/review-explores-cardiovascular-risk-in-certain-patients-with-mpns"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Inflammation and genetic mutations can drive cardiovascular complications in patients with myeloproliferative neoplasms, which include disorders such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/in-myelofibrosis-ruxolitinib-before-and-after-allo-hsct-may-improve-success-rate"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6172b35781bb8a29dc6cf4b785005245ecbd03ec-400x364.jpg?fit=crop&auto=format" alt="Myelofibrosis | Image credit: ASH Image bank" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/in-myelofibrosis-ruxolitinib-before-and-after-allo-hsct-may-improve-success-rate">In Myelofibrosis, Ruxolitinib Before and After Allo-HSCT May Improve Success Rate</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/in-myelofibrosis-ruxolitinib-before-and-after-allo-hsct-may-improve-success-rate"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A review by authors from China examines evidence involving different treatment approaches.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/lack-of-mutations-associated-with-favorable-prognosis-in-mpn-u"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/878ae366156380168a2532815d553cbd597afede-1200x724.jpg?fit=crop&auto=format" alt="Three DNA strands on a blue background | Image credit: Hypnosis - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/lack-of-mutations-associated-with-favorable-prognosis-in-mpn-u">Lack of Mutations Associated With Favorable Prognosis in MPN-U</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/lack-of-mutations-associated-with-favorable-prognosis-in-mpn-u"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While the Dynamic International Prognostic Scoring System and bone marrow blasts may predict overall survival, the lack of certain mutations is also associated with a better prognosis for myeloproliferative neoplasm, unclassifiable (MPN-U).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/utilization-of-momelotinib-for-myelofibrosis-with-anemia-can-result-in-small-savings"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1b666f2bfe935d0536114ee5e312d8f5c043a68c-1280x756.jpg?fit=crop&auto=format" alt="White piggy bank next to a pink stethoscope and various health care icons | Image credit: Kiattisak - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/utilization-of-momelotinib-for-myelofibrosis-with-anemia-can-result-in-small-savings">Utilization of Momelotinib for Myelofibrosis With Anemia Can Result in Small Savings</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/utilization-of-momelotinib-for-myelofibrosis-with-anemia-can-result-in-small-savings"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The introduction of momelotinib to treat myelofibrosis with anemia can result in small savings due to reduced transfusion-related costs, according to a budget impact model.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/follow-up-needs-for-blood-cancer-survivors-may-determine-best-type-of-provider"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cffec80fae08437faae2dd0841782d27fb8bbc5b-6828x4552.jpg?fit=crop&auto=format" alt="Patient meeting with physician Image credit: buritora - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/follow-up-needs-for-blood-cancer-survivors-may-determine-best-type-of-provider">Follow-Up Needs for Blood Cancer Survivors May Determine Best Type of Provider</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/follow-up-needs-for-blood-cancer-survivors-may-determine-best-type-of-provider"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Differing characteristics of the patient and their disease may mean certain providers—academic oncologists, community oncologists, and primary care physicians—may be best suited for follow-up care.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/younger-patients-with-pv-may-benefit-from-earlier-treatment-with-cytoreductive-therapies"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/98649e8393da456a0f9119ad89509a0d840850aa-6000x4000.jpg?fit=crop&auto=format" alt="Polycythemia vera blood cells | Image credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/younger-patients-with-pv-may-benefit-from-earlier-treatment-with-cytoreductive-therapies">Younger Patients With PV May Benefit From Earlier Treatment With Cytoreductive Therapies</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/younger-patients-with-pv-may-benefit-from-earlier-treatment-with-cytoreductive-therapies"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For most patients younger than age 60 with polycythemia vera (PV) who are not considered high risk, cytoreductive therapies are withheld despite being highly effective.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/pegylated-interferons-have-promise-but-also-unmet-potential-in-mpns"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ba641b668e56ab5449e8656de5aaf10d5aa31ad9-1200x724.jpg?fit=crop&auto=format" alt="Blood sample for Myeloproliferative disorders panel | Image Credit: MdBabul - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/pegylated-interferons-have-promise-but-also-unmet-potential-in-mpns">Pegylated Interferons Have Promise but Also Unmet Potential in MPNs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jared-kaltwasser">Jared Kaltwasser</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/pegylated-interferons-have-promise-but-also-unmet-potential-in-mpns"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite potential benefits, the therapy remains in limited use for myeloproliferative neoplasms (MPNs).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/disease--age--genomic-specific-factors-increase-risk-of-et-pv-prepmf-developing-into-overt-mf"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4076019ed10275d5c72502f9b4acc8f07bfbbf82-1280x845.jpg?fit=crop&auto=format" alt="Primary myelofibrosis cells | Image credit: LASZLO - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/disease--age--genomic-specific-factors-increase-risk-of-et-pv-prepmf-developing-into-overt-mf">Disease-, Age-, Genomic-Specific Factors Increase Risk of ET, PV, PrePMF Developing Into Overt MF</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/disease--age--genomic-specific-factors-increase-risk-of-et-pv-prepmf-developing-into-overt-mf"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research highlights the factors that increase the likelihood that essential thrombocytopenia (ET), polycythemia vera (PV), and prefibrotic primary myelofibrosis (PrePMF) will evolve into overt myelofibrosis (MF).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-mpns-have-increased-risk-of-thrombosis-hemorrhage-leukemic-transformation"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/98649e8393da456a0f9119ad89509a0d840850aa-6000x4000.jpg?fit=crop&auto=format" alt="Polycythemia vera red blood cells | Image credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-mpns-have-increased-risk-of-thrombosis-hemorrhage-leukemic-transformation">Patients With MPNs Have Increased Risk of Thrombosis, Hemorrhage, Leukemic Transformation</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-mpns-have-increased-risk-of-thrombosis-hemorrhage-leukemic-transformation"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Compared with matched controls, patients with myeloproliferative neoplasms (MPNs) had a higher risk of developing thrombosis, hemorrhage, and leukemic transformation, according to a longitudinal cohort study. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/aya-with-mpn-face-psychological-needs-that-are-poorly-understood"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/544bbb8e68ea806ae7ccb60d30e677335952bb5f-1280x854.jpg?fit=crop&auto=format" alt="Distressed young woman of color | Image credit: Diego Cervo - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 8th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/aya-with-mpn-face-psychological-needs-that-are-poorly-understood">AYA With MPN Face Psychological Needs That Are Poorly Understood</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/aya-with-mpn-face-psychological-needs-that-are-poorly-understood"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A review of research confirms that adolescents and young adults (AYA) with myeloproliferative neoplasms (MPN) face psychological burdens but the exact burden is poorly understood.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nccn-lists-ropeginterferon-alfa-2b-as-preferred-first-line-cytoreductive-therapy-for-polycythemia-vera"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/610b908f222e40d23039c92a1a04764ffecde2a8-2700x1067.png?fit=crop&auto=format" alt="National Comprehensive Cancer Network (NCCN) logo | Image credit: NCCN" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nccn-lists-ropeginterferon-alfa-2b-as-preferred-first-line-cytoreductive-therapy-for-polycythemia-vera">NCCN Lists Ropeginterferon Alfa-2B as Preferred First-Line Cytoreductive Therapy for Polycythemia Vera</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ashling-wahner">Ashling Wahner</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nccn-lists-ropeginterferon-alfa-2b-as-preferred-first-line-cytoreductive-therapy-for-polycythemia-vera"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The National Comprehensive Cancer Network (NCCN) recommends ropeginterferon alfa-2b as first-line cytoreductive therapy for polycythemia vera.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/reducing-cardiovascular-risk-in-patients-with-polycythemia-vera"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/dfc60c0bfcd84f1e318e0e1341f31e40b80aa46a-5675x3783.jpg?fit=crop&auto=format" alt="Doctor Measuring arterial blood pressure man patient Health care in hospital | joyfotoliakid - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 7th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/reducing-cardiovascular-risk-in-patients-with-polycythemia-vera">Reducing Cardiovascular Risk in Patients With Polycythemia Vera</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/reducing-cardiovascular-risk-in-patients-with-polycythemia-vera"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Polycythemia vera (PV) therapy should aim to identify cardiovascular risk factors, according to one review. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/enhancing-outcomes-and-quality-of-life-for-patients-with-myelofibrosis"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e03bc4fe2794787c6576fa427f8a3ec8535058cc-6016x4000.jpg?fit=crop&auto=format" alt="Diagnosis of Myelofibrosis. Laboratory blood bottle (tube), glass slide with blood smear, hematology test, stethoscope lying on notebook with printed text hematological diagnosis of Myelofibrosis | shidlovski - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 17th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/enhancing-outcomes-and-quality-of-life-for-patients-with-myelofibrosis">Enhancing Outcomes and Quality of Life for Patients With Myelofibrosis</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/enhancing-outcomes-and-quality-of-life-for-patients-with-myelofibrosis"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A phase 3 trial in symptomatic and anemic patients with myelofibrosis (MF) met its primary end point, seeing a significant symptom reduction at 24 weeks with momelotinib vs danazol. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/the-effects-of-aging-on-profiling-epigenetic-changes-in-myeloproliferative-neoplasms"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ae41dbd707aca577e2bb965ea1cf0688ead03882-5934x3876.jpg?fit=crop&auto=format" alt="Rare diseases inscription words. Medical concept of unusual disorders | valiantsin - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 24th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/the-effects-of-aging-on-profiling-epigenetic-changes-in-myeloproliferative-neoplasms">The Effects of Aging on Profiling Epigenetic Changes in Myeloproliferative Neoplasms </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/the-effects-of-aging-on-profiling-epigenetic-changes-in-myeloproliferative-neoplasms"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers identified distinct patterns of epigenetic dysregulation in myeloproliferative neoplasms. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/review-highlights-features-treatment-of-budd-chiari-syndrome-in-mpns"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1ec5ba3f1d20954c743e713a7d43bcc504e4d33b-1280x854.jpg?fit=crop&auto=format" alt="Myeloproliferative Disorders. Myeloproliferative Disorders disease blood test inmedical laboratory: © luchschenF - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 15th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/review-highlights-features-treatment-of-budd-chiari-syndrome-in-mpns">Review Highlights Features, Treatment of Budd-Chiari Syndrome in MPNs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/gianna-melillo">Gianna Melillo</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/review-highlights-features-treatment-of-budd-chiari-syndrome-in-mpns"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Budd-Chiari syndrome and myeloproliferative neoplasms (MPNs) are rare, which means available data are limited. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/integrative-medicine-shows-benefits-for-patients-with-mpns"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aeacfbfef76316d52f2bb4ea2d639f282e926a5a-1698x1131.jpg?fit=crop&auto=format" alt="Yoga" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 12th 2020</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/integrative-medicine-shows-benefits-for-patients-with-mpns">Integrative Medicine Shows Benefits for Patients With MPNs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jaime-rosenberg">Jaime Rosenberg</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/integrative-medicine-shows-benefits-for-patients-with-mpns"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A recent survey of patients with myeloproliferative neoplasms found integrative medicine interventions improved symptom burden, fatigue, depression, and improved quality of life.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/mpn?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/mpn?page=2">2</a><a class="px-4 py-2 border-y border-r" href="/compendium/mpn?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span 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Can you discuss these improvements and the thresholds for symptom improvement that should be used when evaluating new therapies?","_key":"ab6f3ee35fb50","_type":"span"}],"_type":"block","style":"normal","_key":"998b6683d0ce"},{"style":"normal","_key":"aa32fed05ba5","markDefs":[],"children":[{"text":"","_key":"0d5f038841fc","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"b7ebc4b46950","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Momelotinib was one of the first therapies approved with a phase 3 registrational study that had symptomatic improvement as the primary end point, with other important evidence of clinical benefit really as important, a kind of secondary end point, such as improvement in anemia and splenomegaly. This is a JAK [Janus kinase] inhibitor. There is data, both from the frontline and the second line, demonstrating improvement in the symptomatic burden these patients face, as well as improvement in spleen size and in anemia.","_key":"2739537f88450"}],"_type":"block"},{"_key":"6f6e52c11b59","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7eededc320610"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the end, patients really can have 2 concrete benefits from a therapy. They can either live longer, they can live better, or both. Most things that we have are really either a surrogate of one or the other of those really most important end points and outcomes that a therapy can have. In this study for momelotinib, again using patient-reported outcomes, we're able to hear directly from patients the benefits that they experienced. Now, indeed, as we've done threshold work [with] patient-reported outcomes, the patient is really the judge and jury. What is symptomatic enough to benefit from therapy, to be on therapy, is very much assessed through the lens of the individual. We assess their symptoms both in aggregate, using an approach called the total symptom score, where we look at each of the individual symptoms, but as well as complimentary, looking at the worst symptom a patient has and is one able to achieve significant resolution or diminishment of that symptom.","_key":"b81847a98f3c0"}],"_type":"block","style":"normal","_key":"22b97302f781"},{"style":"normal","_key":"c7aa1cd90016","markDefs":[],"children":[{"text":"","_key":"67f47ccffcee0","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"6f1aa95bcfe4","markDefs":[],"children":[{"text":"So, I've used the example, of these methodologies, which can include a score of zero to 100 or in some of the tools, zero to 70. 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I think that's got to be resolved."}],"_type":"block"},{"_type":"block","style":"normal","_key":"40b00eed9ebf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f821e32dc1200"}]},{"style":"normal","_key":"2a0cec3cf2c6","markDefs":[],"children":[{"marks":[],"text":"There is data that has emerged from France about discontinuing interferon after a number of years of therapy. So, is that something that should be explored as part of a paradigm shift? Or you can say, “Listen, we treat patients for a limited time; if the disease is under control, maybe we can stop it and monitor them and retreat as needed?”","_key":"50992863baf30","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b121bf6634050"}],"_type":"block","style":"normal","_key":"5df83dbdf5bb"},{"_type":"block","style":"normal","_key":"5bd150660bc1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I mean, that would be a complete change from the current paradigm of how we treat. 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How do we think about therapies that address those issues?","_key":"eded6eeb2d63"}],"_type":"block","style":"normal","_key":"608caf91e6cd","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"ddb5f3579eee0","_type":"span"}],"_type":"block","style":"normal","_key":"d5ad0e622c01"},{"children":[{"_type":"span","marks":[],"text":"Part of it is a regulatory conundrum in the sense that studies have to meet certain end points for drugs to get approved, but the way we study the drugs is relative to the definitions of the end points that make the drugs successful. In many cases, [the end point is asking] are you controlling the hematocrit adequately? That's one of the major things in polycythemia vera. But in order to really try to get at the question of disease modification, we've got to think about changing the end points of our studies to reflect that.","_key":"9d63107cae5b0"}],"_type":"block","style":"normal","_key":"952f28d3b02a","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"4e4411122f800","_type":"span"}],"_type":"block","style":"normal","_key":"33341391eaf2"},{"children":[{"_type":"span","marks":[],"text":"What are the things that are going to best correlate with the idea that you aren't keeping patients free of the catastrophic consequences of their disease, like blood clots, like [disease] turning into leukemia or myelofibrosis? Are you controlling the patient's symptoms to an adequate degree? Those are the things that I think are fundamental. But we've got to change the end points of our studies to really get at that.","_key":"71b762bd455e0"}],"_type":"block","style":"normal","_key":"ee02d770f664","markDefs":[]},{"style":"normal","_key":"7c1fcffdf902","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d590b0b9afa20"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How do treatments differ between patients with high-risk and low-risk polycythemia vera?","_key":"9fce317840810"}],"_type":"block","style":"normal","_key":"823d213c4dd0"},{"markDefs":[],"children":[{"marks":[],"text":"Right now, the paradigm is that in patients who are low risk, we treat people with aspirin and phlebotomy to keep the hematocrit level under 45%, and if they're high risk, we put them on a therapeutic intervention like Hydrea [hydroxyurea] or ropeginterferon or pegylated interferon. That's the current paradigm. If patients are having lots of phlebotomies or they're having symptoms, then it's reasonable to think about putting them on a therapy.","_key":"10e7399229ae0","_type":"span"}],"_type":"block","style":"normal","_key":"6be9a68af137"},{"markDefs":[],"children":[{"text":"","_key":"6985ff2921d70","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"e1c6dfc0daf2"},{"children":[{"_type":"span","marks":[],"text":"Coming back to the idea that ","_key":"f066f29c11370"},{"text":"with newer data","_key":"f066f29c11371","_type":"span","marks":["b175d227837d"]},{"marks":[],"text":", that paradigm may need to change, in the sense that there is some data that [show] treating the low-risk patients with things like ropeginterferon might make a difference, in terms of controlling their blood counts, maybe controlling for a disease progression.","_key":"f066f29c11372","_type":"span"}],"_type":"block","style":"normal","_key":"8713dcb10921","markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/emerging-data-continue-to-evolve-treatment-utilization-in-mpns","_key":"b175d227837d"}]},{"_key":"7621a63a3973","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9f3b0cee6d290"}],"_type":"block","style":"normal"},{"style":"normal","_key":"78e9950b1ead","markDefs":[],"children":[{"_key":"280bbc7f032c0","_type":"span","marks":[],"text":"I think that there needs to be more data in this space. Is this really the right approach? I mean, this has been the historic approach, this has been the paradigm that everybody follows. But it begs the question, is that really the right approach? As we have more active agents in this space, I think we've got to refine our questions and focus on those questions."}],"_type":"block"},{"children":[{"marks":[],"text":"","_key":"effe089680980","_type":"span"}],"_type":"block","style":"normal","_key":"40752f5d06f2","markDefs":[]},{"_type":"block","style":"normal","_key":"4eea451cbc0e","markDefs":[],"children":[{"marks":["strong"],"text":"Is there anything specific of interest in the pipeline that might change how polycythemia vera is treated?","_key":"548fda8b29b90","_type":"span"}]},{"_key":"c10377ec848a","markDefs":[],"children":[{"_key":"d703c2c347cf0","_type":"span","marks":[],"text":"There is this drug rusfertide, a hepcidin memetic, which in phase 2 studies has shown promise in helping patients become phlebotomy independent, which is an important end point. Phlebotomy is not a bit of a benign thing; I think that's an important thing for everyone to realize. People become iron deficient [with too many phlebotomies]. Iron deficiency can cause symptoms, things like restless leg syndrome, and there is data that long-term phlebotomies and becoming iron deficient may lead to or be associated with things like pulmonary hypertension. Thinking of phlebotomy as a benign intervention and using medications as not a benign intervention is perhaps the wrong way to be thinking about this."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"908995d267a10","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"1fb4b8551dde"},{"_type":"block","style":"normal","_key":"a6cb4ed98928","markDefs":[],"children":[{"_key":"d239199f1a120","_type":"span","marks":[],"text":"These medications like rusfertide that could make a difference there. And there is more and more emerging data with ruxolitinib, and it's absolutely a highly effective drug to treat polycythemia vera. The question is, how deep of a response? 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How does it look different today?"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I guess it's more a question of utilization than the landscape, in the sense that both things like hydroxyurea and interferons and drugs, like an anagrelide for ET [essential thrombocythemia], have been around for quite some time. And I think that it hasn't been clear for the majority of that time which drugs should be used when and by whom.","_key":"e5ae9e1c70ce0"}],"_type":"block","style":"normal","_key":"8027d37ce752"},{"_type":"block","style":"normal","_key":"9632447f471a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"dc27e5acd9ca0"}]},{"markDefs":[],"children":[{"_key":"87d81815cd880","_type":"span","marks":[],"text":"There is now randomized clinical trial data for pegylated interferon vs hydroxyurea, but more recently, particularly with regards to polycythemia vera, there's randomized data with ropeginterferon and hydroxyurea. And at least in that data set, the [blood] count control was superior with ropeginterferon vs hydroxyurea over the course of a number of years. Initially, at 1 year, there wasn't so much of a difference, but as time went on, there was clearly a difference that favored the use of ropeginterferon in terms of controlling the blood counts. Similarly, over time, there does seem to be a decrease in the JAK [Janus kinase] 2 mutation burden in the patients who got the ropeginterferon."}],"_type":"block","style":"normal","_key":"80562745f2a5"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9979821986010"}],"_type":"block","style":"normal","_key":"9a79ad549faf"},{"style":"normal","_key":"e828953e1624","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think that there is an emerging data set that is arguing that there are benefits to interferon. Going back to the initial point here, the landscape has changed to some degree—with the introduction of something like ropeginterferon—but I think it's more that the data is evolving, which is beginning to tell us maybe which drugs might be best for which patients. We're not completely there by any stretch of the imagination, but the data is beginning to coalesce around the message.","_key":"759368cbb9900"}],"_type":"block"}],"summary":"Despite being used for decades, there continues to be emerging data on interferons and how they should be used in patients with myeloproliferative neoplasms (MPNs), explains Raajit Rampal, MD, PhD, hematologic oncologist, associate attending physician, Memorial Sloan Kettering Cancer Center."},{"authorMapping":[{"lastName":"Joszt","biography":[{"markDefs":[{"_type":"link","href":"https://www.linkedin.com/in/laura-joszt-05ba7116/","_key":"f77b28536a8d"},{"_type":"link","href":"https://twitter.com/joszt","_key":"c419f18a7ffe"}],"children":[{"_type":"span","marks":[],"text":"Laura is the vice president of content for The American Journal of Managed Care® (AJMC®) and all its brands, including The American Journal of Accountable Care®, Evidence-Based Oncology™, and The Center for Biosimilars®. 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There were interferons that were given 3 times a week, and pegylated interferon, which is what we use most often, and now there's ropeginterferon, which is every 2 weeks as a treatment.","_key":"5ad7c73d31d9","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"f8215ec12b8e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f876711ce47a0"}]},{"_key":"d87002a76371","markDefs":[],"children":[{"_key":"ad934deb89950","_type":"span","marks":[],"text":"What the interferons can do, for sure, is that they can reduce blood counts. So, for people with the polycythemia or with essential thrombocytopenia, we can get a reduction in the blood counts in the majority of patients. What is also interesting is that—and as has been known now for a number of years—the allele burden, particularly of JAK2, can decrease over time with the treatment with interferons, which at least would suggest to us that you may be depleting part of the clone that causes the disease. So, there are certainly a number of important clinical benefits of interferons, but even potentially biological effects."}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"50313adc7f780"}],"_type":"block","style":"normal","_key":"62458a6ae21b","markDefs":[]},{"style":"normal","_key":"0c9d438624eb","markDefs":[],"children":[{"marks":["strong"],"text":"Beyond interferons and hydroxyurea, what other important treatment options are there for patients with MPNs and how are they used?","_key":"bf0301f593b00","_type":"span"}],"_type":"block"},{"style":"normal","_key":"ec667068453d","markDefs":[],"children":[{"marks":[],"text":"I think there are a lot of emerging therapies, which is exciting, right? We're past where we were in terms of our therapeutic armamentarium. JAK inhibitors clearly have made a huge mark on MPNs. For polycythemia vera, ruxolitinib was approved as a second-line therapy after hydroxyurea. The data continues to get stronger and stronger for ruxolitinib in polycythemia vera, where there's clearly a superiority in terms of hematocrit control and spleen size control for patients who had been on hydroxyurea previously. It also seems like it is certainly a very effective drug to control symptom burden in our polycythemia vera patients.","_key":"15efa4c6b9030","_type":"span"}],"_type":"block"},{"_key":"8ed5bc132b58","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"72c041b34cf20"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"98f84d7086eb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"There are studies ongoing in Europe right now—there was data presented at the American Society of Hematology annual meeting this year about upfront treatment.","_key":"3a382c62ea370"},{"text":"2","_key":"79a0c082bf8a","_type":"span","marks":["superscript"]},{"_key":"c014e1a8cf79","_type":"span","marks":[],"text":" So I think that there's more to be learned there, as well. JAK inhibitors have also been trialed in essential thrombocytopenia with the data today being somewhat equivocal. But clearly ruxolitinib, in particular, has activity in that setting. 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I think that their opinions are really about what their priorities are in terms of their cancer experience are the aspects that should be shaping how we mold value-based care and are planning for it as we move to those sorts of models in health care.","_key":"ac8d842cbfb00"}],"_type":"block","style":"normal","_key":"9cd525b53994","markDefs":[]},{"_type":"block","style":"normal","_key":"a955f8251779","markDefs":[],"children":[{"marks":[],"text":"","_key":"9411ef551f610","_type":"span"}]},{"children":[{"text":"In terms of, specifically, myelodysplastic syndromes and myeloproliferative disorders, they are part of an ever-growing catchment of cancer patients that have more chronic disease or at least a subset of them have actually more chronic disease, and so they’re going to have a more long-term cancer experience. So, their relationship with their providers and with the health care system, is going to be extended for many years if not decades.","_key":"dbeba88f69580","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"8695c16d6569","markDefs":[]},{"style":"normal","_key":"98a2c380e71a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a61b831c36a20"}],"_type":"block"},{"_type":"block","style":"normal","_key":"c0be8d5606c7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"And so, I think realizing upfront, this is going to be a long-term commitment and a long-term relationship, speaking at the beginning: how do they define what they find valuable in their treatment experience. And what are going to be their priorities as they continue to get care, whether that be increased longevity, increased quality of life, thinking about their financial well-being and avoid the financial toxicity, or participation in research that helps them to feel like they're contributing to the development of new therapies as a whole.","_key":"7d94f19ed5580"}]}],"title":"Dr Jennifer Vaughn: Patients With MPN, MDS Should Discuss Long-Term Priorities 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