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KEGG DRUG: Sitagliptin phosphate
<!doctype html> <html><head> <title>KEGG DRUG: Sitagliptin phosphate</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1744206093"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1744206093"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1744206093" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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} } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="668"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D06645"></a><font class="title5">DRUG: Sitagliptin phosphate</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D06645 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Sitagliptin phosphate (USAN);<br>Sitagliptin phosphate hydrate (JP18);<br>Sitagliptin phosphate monohydrate;<br>Januvia (TN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td50 defd"><div class="cel"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=194c3718-5eb5-4cf5-85d0-2bb1ed8293b8">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1b03c82f-b52e-4092-b9dc-f2c9b0d6ab40">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=24e22e28-ec43-47e8-969f-788268ccba12">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4a758211-8af1-449b-9a10-f3d67d7ec8b6">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=62c4f58b-2b28-4825-aeb6-213ab9b7a026">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=92829830-b869-4ec8-b498-73f5b2e8e7be">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e2e576e6-6181-4178-b989-61d0e795e559">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=eb81a45f-05b8-49de-99ce-5089bd360d9b">JANUVIA (A-S Medication Solutions)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=39253ddd-0245-43b1-ad28-d5923983afb4">JANUVIA (Cardinal Health 107)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9d558f96-24a5-4788-8933-38256c17384b">JANUVIA (Cardinal Health 107)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f85a48d0-0407-4c50-b0fa-7673a160bf01">JANUVIA (Merck Sharp & Dohme LLC)</a></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td51 defd"><div class="cel">C16H15F6N5O. H3PO4. H2O<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td50 defd"><div class="cel">523.1055<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td51 defd"><div class="cel">523.32<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td50 defd"><a href="/Fig/drug/D06645.gif"><img name="img0" src="/Fig/drug/D06645.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D06645';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D06645';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D06645&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D06645';return false;">Neighbor</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td50 defd"><div class="cel"><span class="nowrap">Antidiabetic agent<br> <a href="/entry/DG02044">DG02044</a> Hypoglycemic agent<br> <a href="/entry/DG01601">DG01601</a> DPP-4 inhibitor<br> </span></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Therapeutic category: </span></td><td><a href="/brite/br08301+D06645">3969</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D06645">A10BH01</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Chemical structure group: </span></td><td><a href="/entry/DG00118">DG00118</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product (DG00118): </span></td><td>D08516<<a href="/entry/D08516">US</a>> D06645<<a href="/entry/dr_ja:D06645">JP</a>/US> </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product (mixture): </span></td><td>D10261<<a href="/entry/D10261">US</a>> D11064<<a href="/entry/dr_ja:D11064">JP</a>> D11066<<a href="/entry/D11066">US</a>> </td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td50 defd"><div class="cel">Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor</div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Disease</span></th> <td class="td51 repd"><div class="cel">Type 2 diabetes mellitus [DS:<a href="/entry/H00409">H00409</a>]</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td50 defd"><div class="cel">Mixture of Juvisync (TN)<br> Treatment of type 2 diabetes mellitus and related disorders<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td51 defd"><div class="cel">DPP4 (CD26) [HSA:<a href="/entry/hsa:1803">1803</a>] [KO:<a href="/entry/K01278">K01278</a>]</div></td></tr> <tr><th class="th50 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td50 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04974+1803">hsa04974</a> </span></td><td>Protein digestion and absorption</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td51 defd"><div class="cel"><button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D06645';return false;">DDI search</button></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Structure map</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07051+D06645">map07051</a> </span></td><td>Antidiabetics</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D06645">br08303</a>]<br> A ALIMENTARY TRACT AND METABOLISM<br> A10 DRUGS USED IN DIABETES<br> A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS<br> A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors<br> A10BH01 Sitagliptin<br> D06645 Sitagliptin phosphate (USAN) <JP/US><br> USP drug classification [BR:<a href="/brite/br08302+D06645">br08302</a>]<br> Blood Glucose Regulators<br> Antidiabetic Agents<br> Dipeptidyl Peptidase-4 (DPP-4) Inhibitor<br> Sitagliptin<br> D06645 Sitagliptin phosphate (USAN)<br> Therapeutic category of drugs in Japan [BR:<a href="/brite/br08301+D06645">br08301</a>]<br> 3 Agents affecting metabolism<br> 39 Other agents affecting metabolism<br> 396 Antidiabetic agents<br> 3969 Others<br> D06645 Sitagliptin phosphate (USAN); Sitagliptin phosphate hydrate (JP18)<br> Drug groups [BR:<a href="/brite/br08330+D06645+DG02044">br08330</a>]<br> Antidiabetic agent<br> DG02044 Hypoglycemic agent<br> DG01601 DPP-4 inhibitor<br> DG00118 Sitagliptin<br> D06645 Sitagliptin phosphate<br> Drug classes [BR:<a href="/brite/br08332+D06645+DG01601">br08332</a>]<br> Antidiabetic agent<br> DG01601 DPP-4 inhibitor<br> D06645 Sitagliptin phosphate<br> DG02044 Hypoglycemic agent<br> D06645 Sitagliptin phosphate<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D06645">br08310</a>]<br> Peptidases and inhibitors<br> Serine peptidases<br> Prolyl oligopeptidase family<br> DPP4 (CD26)<br> D06645 Sitagliptin phosphate (USAN) <JP/US><br> Drugs listed in the Japanese Pharmacopoeia [BR:<a href="/brite/br08311+D06645">br08311</a>]<br> Chemicals<br> D06645 Sitagliptin phosphate hydrate<br> D06645 Sitagliptin phosphate tablets<br> New drug approvals in the USA [<a href="/kegg/drug/br08319.html?id=D06645">br08319.html</a>]<br> New molecular entities and new therapeutic biological products<br> D06645<br> New drug approvals in Europe [<a href="/kegg/drug/br08329.html?id=D06645">br08329.html</a>]<br> European public assessment reports (EPAR) authorised medicine<br> D06645<br> New drug approvals in Japan [<a href="/kegg/drug/br08318.html?id=D06645">br08318.html</a>]<br> Drugs with new active ingredients<br> D06645<br> New drug approvals in the USA, Europe and Japan [<a href="/kegg/drug/br08328.html?id=D06645">br08328.html</a>]<br> Approval dates by FDA, EMA and PMDA<br> D06645<br> Drug groups [BR:<a href="/brite/br08330+D06645+DG02044">br08330</a>]<br> Antidiabetic agent<br> DG02044 Hypoglycemic agent<br> DG01601 DPP-4 inhibitor<br> DG00118 Sitagliptin<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D06645';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>654671-77-9</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=47208296">47208296</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D06645&source=KEGG_DRUG">D06645</a></td></tr></table></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D06645';return false;">All DBs</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td50 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 34<br> 1 C8y C 8.1200 -12.2500<br> 2 C8x C 8.1200 -13.6500<br> 3 C8y C 9.3324 -14.3500<br> 4 C8y C 10.5449 -13.6500<br> 5 C8x C 10.5449 -12.2500<br> 6 C8y C 9.3324 -11.5500<br> 7 X F 9.3324 -10.1502<br> 8 X F 9.3324 -15.7498<br> 9 X F 6.9076 -11.5500<br> 10 C1b C 11.7760 -14.3610<br> 11 C1c C 12.9812 -13.6653<br> 12 C1b C 14.1635 -14.3481<br> 13 C5a C 15.3575 -13.6588<br> 14 N1y N 16.5454 -14.3448<br> 15 O5a O 15.3577 -12.2503<br> 16 N1a N 12.9816 -12.2504<br> 17 C1x C 16.5454 -15.7498<br> 18 C1x C 17.7578 -16.4498<br> 19 N4y N 18.9703 -15.7498<br> 20 C8y C 18.9703 -14.3448<br> 21 C1x C 17.7579 -13.6448<br> 22 C8y C 20.3065 -16.1840<br> 23 N5x N 21.1324 -15.0474<br> 24 N5x N 20.3065 -13.9107<br> 25 C1d C 20.3065 -17.5840<br> 26 X F 20.3065 -18.9840<br> 27 X F 21.6999 -17.5839<br> 28 X F 18.9001 -17.5841<br> 29 P1b P 24.7529 -13.5722<br> 30 O1c O 26.0648 -13.5841<br> 31 O1c O 23.5239 -13.5841<br> 32 O1c O 24.8120 -15.0030<br> 33 O1c O 24.7882 -11.9456<br> 34 O0 O 25.6900 -17.7100<br> BOND 34<br> 1 1 2 2<br> 2 2 3 1<br> 3 3 4 2<br> 4 4 5 1<br> 5 5 6 2<br> 6 1 6 1<br> 7 6 7 1<br> 8 3 8 1<br> 9 1 9 1<br> 10 4 10 1<br> 11 10 11 1<br> 12 11 12 1<br> 13 12 13 1<br> 14 13 14 1<br> 15 13 15 2<br> 16 11 16 1 #Up<br> 17 14 17 1<br> 18 17 18 1<br> 19 18 19 1<br> 20 19 20 1<br> 21 20 21 1<br> 22 14 21 1<br> 23 19 22 1<br> 24 22 23 2<br> 25 23 24 1<br> 26 20 24 2<br> 27 22 25 1<br> 28 25 26 1<br> 29 25 27 1<br> 30 25 28 1<br> 31 29 30 1<br> 32 29 31 1<br> 33 29 32 1<br> 34 29 33 2<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D06645">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>