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Search results for: misfired cartridge

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</div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: misfired cartridge</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Aporia, Daze and Arcanes during Visit to Scene of Crime: A Case History</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20S.%20Grewal">A. S. Grewal</a>, <a href="https://publications.waset.org/abstracts/search?q=Sh.%20Dharambir"> Sh. Dharambir</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20S.%20Sangwan"> R. S. Sangwan</a>, <a href="https://publications.waset.org/abstracts/search?q=Vikas%20Dhanda"> Vikas Dhanda </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Every Scene of Crime is of different kind in nature. Sometimes we see such type of circumstances that we become confused to judge whether the case is of homicide or suicide. In such circumstances a doyen is asked for the option. On the basis of his esoteric knowledge he finds such clues which force the sleuth to change the under sections of Indian penal Code. Here we have examined a case by visiting Scene of Crime and found that a person was found lying dead in a room. There was only one passage which was found opened, the pistol along with the fired cartridge case, misfired cartridge were lying on the spot. Observation method, mathematical calculations, chemical examination and other aspects were considered. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=country-made%20pistol" title="country-made pistol">country-made pistol</a>, <a href="https://publications.waset.org/abstracts/search?q=misfired%20cartridge" title=" misfired cartridge"> misfired cartridge</a>, <a href="https://publications.waset.org/abstracts/search?q=fired%20cartridge%20case" title=" fired cartridge case"> fired cartridge case</a>, <a href="https://publications.waset.org/abstracts/search?q=blackening" title=" blackening"> blackening</a>, <a href="https://publications.waset.org/abstracts/search?q=nitrite" title=" nitrite"> nitrite</a> </p> <a href="https://publications.waset.org/abstracts/7867/aporia-daze-and-arcanes-during-visit-to-scene-of-crime-a-case-history" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7867.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">396</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> Fingerprint on Ballistic after Shooting</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Narong%20Kulnides">Narong Kulnides</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research involved fingerprints on ballistics after shooting. Two objectives of research were as follows; (1) to study the duration of the existence of latent fingerprints on .38, .45, 9 mm and .223 cartridge case after shooting, and (2) to compare the effectiveness of the detection of latent fingerprints by Black Powder, Super Glue, Perma Blue and Gun Bluing. The latent fingerprint appearance were studied on .38, .45, 9 mm. and .223 cartridge cases before and after shooting with Black Powder, Super Glue, Perma Blue and Gun Bluing. The detection times were 3 minute, 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, 66, 72, 78 and 84 hours respectively. As a result of the study, it can be conclude that: (1) Before shooting, the detection of latent fingerprints on 38, .45, and 9 mm. and .223 cartridge cases with Black Powder, Super Glue, Perma Blue and Gun Bluing can detect the fingerprints at all detection times. (2) After shooting, the detection of latent fingerprints on .38, .45, 9 mm. and .223 cartridge cases with Black Powder, Super Glue did not appear. The detection of latent fingerprints on .38, .45, 9 mm. cartridge cases with Perma Blue and Gun Bluing were found 100% of the time and the detection of latent fingerprints on .223 cartridge cases with Perma Blue and Gun Bluing were found 40% and 46.67% of the time, respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ballistic" title="ballistic">ballistic</a>, <a href="https://publications.waset.org/abstracts/search?q=fingerprint" title=" fingerprint"> fingerprint</a>, <a href="https://publications.waset.org/abstracts/search?q=shooting" title=" shooting"> shooting</a>, <a href="https://publications.waset.org/abstracts/search?q=detection%20times" title=" detection times"> detection times</a> </p> <a href="https://publications.waset.org/abstracts/10363/fingerprint-on-ballistic-after-shooting" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10363.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">418</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> Analysis of DNA from Fired Cartridge Casings</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Mawlood">S. Mawlood</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Denanny"> L. Denanny</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Watson"> N. Watson</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Pickard"> B. Pickard</a> </p> <p class="card-text"><strong>Abstract:</strong></p> DNA analysis has been widely accepted as providing valuable evidence concerning the identity of the source of biological traces. Our work has showed that DNA samples can survive on cartridges even after firing. The study also raised the possibility of determining other information such as the age of the donor. Such information may be invaluable in certain cases where spent cartridges from automatic weapons are left behind at the scene of a crime. In spite of the nature of touch evidence and exposure to high chamber temperatures during shooting, we were still capable to retrieve enough DNA for profile typing. In order to estimate age of contributor, DNA methylation levels were analyzed using EpiTect system for retrieved DNA. However, results were not conclusive, due to low amount of input DNA. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DNA%20profile" title="DNA profile">DNA profile</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20Methylation" title=" DNA Methylation"> DNA Methylation</a>, <a href="https://publications.waset.org/abstracts/search?q=fired%20cartridge" title=" fired cartridge"> fired cartridge</a>, <a href="https://publications.waset.org/abstracts/search?q=touch%20sample" title=" touch sample"> touch sample</a> </p> <a href="https://publications.waset.org/abstracts/24507/analysis-of-dna-from-fired-cartridge-casings" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24507.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">452</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> Additional Method for the Purification of Lanthanide-Labeled Peptide Compounds Pre-Purified by Weak Cation Exchange Cartridge</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Eryilmaz">K. Eryilmaz</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Mercanoglu"> G. Mercanoglu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: Purification of the final product, which is the last step in the synthesis of lanthanide-labeled peptide compounds, can be accomplished by different methods. Among these methods, the two most commonly used methods are C18 solid phase extraction (SPE) and weak cation exchanger cartridge elution. SPE C18 solid phase extraction method yields high purity final product, while elution from the weak cation exchanger cartridge is pH dependent and ineffective in removing colloidal impurities. The aim of this work is to develop an additional purification method for the lanthanide-labeled peptide compound in cases where the desired radionuclidic and radiochemical purity of the final product can not be achieved because of pH problem or colloidal impurity. Material and Methods: For colloidal impurity formation, 3 mL of water for injection (WFI) was added to 30 mCi of 177LuCl3 solution and allowed to stand for 1 day. 177Lu-DOTATATE was synthesized using EZAG ML-EAZY module (10 mCi/mL). After synthesis, the final product was mixed with the colloidal impurity solution (total volume:13 mL, total activity: 40 mCi). The resulting mixture was trapped in SPE-C18 cartridge. The cartridge was washed with 10 ml saline to remove impurities to the waste vial. The product trapped in the cartridge was eluted with 2 ml of 50% ethanol and collected to the final product vial via passing through a 0.22μm filter. The final product was diluted with 10 mL of saline. Radiochemical purity before and after purification was analysed by HPLC method. (column: ACE C18-100A. 3µm. 150 x 3.0mm, mobile phase: Water-Acetonitrile-Trifluoro acetic acid (75:25:1), flow rate: 0.6 mL/min). Results: UV and radioactivity detector results in HPLC analysis showed that colloidal impurities were completely removed from the 177Lu-DOTATATE/ colloidal impurity mixture by purification method. Conclusion: The improved purification method can be used as an additional method to remove impurities that may result from the lanthanide-peptide synthesis in which the weak cation exchange purification technique is used as the last step. The purification of the final product and the GMP compliance (the final aseptic filtration and the sterile disposable system components) are two major advantages. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lanthanide" title="lanthanide">lanthanide</a>, <a href="https://publications.waset.org/abstracts/search?q=peptide" title=" peptide"> peptide</a>, <a href="https://publications.waset.org/abstracts/search?q=labeling" title=" labeling"> labeling</a>, <a href="https://publications.waset.org/abstracts/search?q=purification" title=" purification"> purification</a>, <a href="https://publications.waset.org/abstracts/search?q=radionuclide" title=" radionuclide"> radionuclide</a>, <a href="https://publications.waset.org/abstracts/search?q=radiopharmaceutical" title=" radiopharmaceutical"> radiopharmaceutical</a>, <a href="https://publications.waset.org/abstracts/search?q=synthesis" title=" synthesis"> synthesis</a> </p> <a href="https://publications.waset.org/abstracts/96095/additional-method-for-the-purification-of-lanthanide-labeled-peptide-compounds-pre-purified-by-weak-cation-exchange-cartridge" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96095.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> All-In-One Universal Cartridge Based Truly Modular Electrolyte Analyzer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Dalvi">S. Dalvi</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Sane"> N. Sane</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Patil"> V. Patil</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Bansode"> D. Bansode</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Tharakan"> A. Tharakan</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Mathur"> V. Mathur</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Measurement of routine clinical electrolyte tests is common in labs worldwide for screening of illness or diseases. All the analyzers for the measurement of electrolyte parameters have sensors, reagents, sampler, pump tubing, valve, other tubing’s separate that are either expensive, require heavy maintenance and have a short shelf-life. Moreover, the costs required to maintain such Lab instrumentation is high and this limits the use of the device to only highly specialized personnel and sophisticated labs. In order to provide Healthcare Diagnostics to ALL at affordable costs, there is a need for an All-in-one Universal Modular Cartridge that contains sensors, reagents, sampler, valve, pump tubing, and other tubing’s in one single integrated module-in-module cartridge that is affordable, reliable, easy-to-use, requires very low sample volume and is truly modular and maintenance-free. DiaSys India has developed a World’s first, Patent Pending, Versatile All-in-one Universal Module-in-Module Cartridge based Electrolyte Analyzer (QDx InstaLyte) that can perform sodium, potassium, chloride, calcium, pH, lithium tests. QDx InstaLyte incorporates High Performance, Inexpensive All-in-one Universal Cartridge for rapid quantitative measurement of electrolytes in body fluids. Our proposed methodology utilizes Advanced & Improved long life ISE sensors to provide a sensitive and accurate result in 120 sec with just 100 µl of sample volume. The All-in-One Universal Cartridge has a very low reagent consumption capable of maximum of 1000 tests with a Use-life of 3-4 months and a long Shelf life of 12-18 months at 4-25°C making it very cost-effective. Methods: QDx InstaLyte analyzers with All-in-one Universal Modular Cartridges were independently evaluated with three R&D lots for Method Performance (Linearity, Precision, Method Comparison, Cartridge Stability) to measure Sodium, Potassium, Chloride. Method Comparison was done against Medica EasyLyte Plus Na/K/Cl Electrolyte Analyzer, a mid-size lab based clinical chemistry analyzer with N = 100 samples run over 10 days. Within-run precision study was done using modified CLSI guidelines with N = 20 samples and day-to-day precision study was done for 7 consecutive days using Trulab N & P Quality Control Samples. Accelerated stability testing was done at 45oC for 4 weeks with Production Lots. Results: Data analysis indicates that the CV for within-run precision for Na is ≤ 1%, for K is ≤2%, and for Cl is ≤2% and with R2 ≥ 0.95 for Method Comparison. Further, the All-in-One Universal Cartridge is stable up to 12-18 months at 4-25oC storage temperature based on preliminary extrapolated data. Conclusion: The Developed Technology Platform of All-in-One Universal Module-in-Module Cartridge based QDx InstaLyte is Reliable and meets all the performance specifications of the lab and is Truly Modular and Maintenance-Free. Hence, it can be easily adapted for low cost, sensitive and rapid measurement of electrolyte tests in low resource settings such as in urban, semi-urban and rural areas in the developing countries and can be used as a Point-of-care testing system for worldwide applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=all-in-one%20modular%20catridge" title="all-in-one modular catridge">all-in-one modular catridge</a>, <a href="https://publications.waset.org/abstracts/search?q=electrolytes" title=" electrolytes"> electrolytes</a>, <a href="https://publications.waset.org/abstracts/search?q=maintenance%20free" title=" maintenance free"> maintenance free</a>, <a href="https://publications.waset.org/abstracts/search?q=QDx%20instalyte" title=" QDx instalyte"> QDx instalyte</a> </p> <a href="https://publications.waset.org/abstracts/192088/all-in-one-universal-cartridge-based-truly-modular-electrolyte-analyzer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192088.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">30</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> PTFE Capillary-Based DNA Amplification within an Oscillatory Thermal Cycling Device</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jyh%20J.%20Chen">Jyh J. Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Fu%20H.%20Yang"> Fu H. Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ming%20H.%20Liao"> Ming H. Liao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study describes a capillary-based device integrated with the heating and cooling modules for polymerase chain reaction (PCR). The device consists of the reaction polytetrafluoroethylene (PTFE) capillary, the aluminum blocks, and is equipped with two cartridge heaters, a thermoelectric (TE) cooler, a fan, and some thermocouples for temperature control. The cartridge heaters are placed into the heating blocks and maintained at two different temperatures to achieve the denaturation and the extension step. Some thermocouples inserted into the capillary are used to obtain the transient temperature profiles of the reaction sample during thermal cycles. A 483-bp DNA template is amplified successfully in the designed system and the traditional thermal cycler. This work should be interesting to persons involved in the high-temperature based reactions and genomics or cell analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polymerase%20chain%20reaction" title="polymerase chain reaction">polymerase chain reaction</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20cycles" title=" thermal cycles"> thermal cycles</a>, <a href="https://publications.waset.org/abstracts/search?q=capillary" title=" capillary"> capillary</a>, <a href="https://publications.waset.org/abstracts/search?q=TE%20cooler" title=" TE cooler"> TE cooler</a> </p> <a href="https://publications.waset.org/abstracts/7439/ptfe-capillary-based-dna-amplification-within-an-oscillatory-thermal-cycling-device" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7439.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">454</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Strategy of Inventory Analysis with Economic Order Quantity and Quick Response: Case on Filter Inventory for Heavy Equipment in Indonesia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lim%20Sanny">Lim Sanny</a>, <a href="https://publications.waset.org/abstracts/search?q=Felix%20Christian"> Felix Christian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The use of heavy equipment in Indonesia is always increasing. Cost reduction in procurement of spare parts is the aim of the company. The spare parts in this research are focused in the kind of filters. On the early step, the choosing of priority filter will be studied further by using the ABC analysis. To find out future demand of the filter, this research is using demand forecast by utilizing the QM software for windows. And to find out the best method of inventory control for each kind of filter is by comparing the total cost of Economic Order Quantity and Quick response inventory method. For the three kind of filters which are Cartridge, Engine oil – pn : 600-211-123, Element, Transmission – pn : 424-16-11140, and Element, Hydraulic – pn : 07063-01054, the best forecasting method is Linear regression. The best method for inventory control of Cartridge, Engine oil – pn : 600-211-123 and Element, Transmission – pn : 424-16-11140, is Quick Response Inventory, while the best method for Element, Hydraulic – pn : 07063-01054 is Economic Order Quantity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=strategy" title="strategy">strategy</a>, <a href="https://publications.waset.org/abstracts/search?q=inventory" title=" inventory"> inventory</a>, <a href="https://publications.waset.org/abstracts/search?q=ABC%20analysis" title=" ABC analysis"> ABC analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=forecasting" title=" forecasting"> forecasting</a>, <a href="https://publications.waset.org/abstracts/search?q=economic%20order%20quantity" title=" economic order quantity"> economic order quantity</a>, <a href="https://publications.waset.org/abstracts/search?q=quick%20response%20inventory" title=" quick response inventory"> quick response inventory</a> </p> <a href="https://publications.waset.org/abstracts/19597/strategy-of-inventory-analysis-with-economic-order-quantity-and-quick-response-case-on-filter-inventory-for-heavy-equipment-in-indonesia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19597.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> A Low-Cost Disposable PDMS Microfluidic Cartridge with Reagent Storage Silicone Blisters for Isothermal DNA Amplification</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=L.%20Ereku">L. Ereku</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20E.%20Mackay"> R. E. Mackay</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Naveenathayalan"> A. Naveenathayalan</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Ajayi"> K. Ajayi</a>, <a href="https://publications.waset.org/abstracts/search?q=W.%20Balachandran"> W. Balachandran</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Over the past decade the increase of sexually transmitted infections (STIs) especially in the developing world due to high cost and lack of sufficient medical testing have given rise to the need for a rapid, low cost point of care medical diagnostic that is disposable and most significantly reproduces equivocal results achieved within centralised laboratories. This paper present the development of a disposable PDMS microfluidic cartridge incorporating blisters filled with reagents required for isothermal DNA amplification in clinical diagnostics and point-of-care testing. In view of circumventing the necessity for external complex microfluidic pumps, designing on-chip pressurised fluid reservoirs is embraced using finger actuation and blister storage. The fabrication of the blisters takes into consideration three proponents that include: material characteristics, fluid volume and structural design. Silicone rubber is the chosen material due to its good chemical stability, considerable tear resistance and moderate tension/compression strength. The case of fluid capacity and structural form go hand in hand as the reagent need for the experimental analysis determines the volume size of the blisters, whereas the structural form has to be designed to provide low compression stress when deformed for fluid expulsion. Furthermore, the top and bottom section of the blisters are embedded with miniature polar opposite magnets at a defined parallel distance. These magnets are needed to lock or restrain the blisters when fully compressed so as to prevent unneeded backflow as a result of elasticity. The integrated chip is bonded onto a large microscope glass slide (50mm x 75mm). Each part is manufactured using a 3D printed mould designed using Solidworks software. Die-casting is employed, using 3D printed moulds, to form the deformable blisters by forcing a proprietary liquid silicone rubber through the positive mould cavity. The set silicone rubber is removed from the cast and prefilled with liquid reagent and then sealed with a thin (0.3mm) burstable layer of recast silicone rubber. The main microfluidic cartridge is fabricated using classical soft lithographic techniques. The cartridge incorporates microchannel circuitry, mixing chamber, inlet port, outlet port, reaction chamber and waste chamber. Polydimethylsiloxane (PDMS, QSil 216) is mixed and degassed using a centrifuge (ratio 10:1) is then poured after the prefilled blisters are correctly positioned on the negative mould. Heat treatment of about 50C to 60C in the oven for about 3hours is needed to achieve curing. The latter chip production stage involves bonding the cured PDMS to the glass slide. A plasma coroner treater device BD20-AC (Electro-Technic Products Inc., US) is used to activate the PDMS and glass slide before they are both joined and adequately compressed together, then left in the oven over the night to ensure bonding. There are two blisters in total needed for experimentation; the first will be used as a wash buffer to remove any remaining cell debris and unbound DNA while the second will contain 100uL amplification reagents. This paper will present results of chemical cell lysis, extraction using a biopolymer paper membrane and isothermal amplification on a low-cost platform using the finger actuated blisters for reagent storage. The platform has been shown to detect 1x105 copies of Chlamydia trachomatis using Recombinase Polymerase Amplification (RPA). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=finger%20actuation" title="finger actuation">finger actuation</a>, <a href="https://publications.waset.org/abstracts/search?q=point%20of%20care" title=" point of care"> point of care</a>, <a href="https://publications.waset.org/abstracts/search?q=reagent%20storage" title=" reagent storage"> reagent storage</a>, <a href="https://publications.waset.org/abstracts/search?q=silicone%20blisters" title=" silicone blisters "> silicone blisters </a> </p> <a href="https://publications.waset.org/abstracts/32115/a-low-cost-disposable-pdms-microfluidic-cartridge-with-reagent-storage-silicone-blisters-for-isothermal-dna-amplification" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32115.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">368</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Rapid Detection System of Airborne Pathogens</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shigenori%20Togashi">Shigenori Togashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kei%20Takenaka"> Kei Takenaka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We developed new processes which can collect and detect rapidly airborne pathogens such as the avian flu virus for the pandemic prevention. The fluorescence antibody technique is known as one of high-sensitive detection methods for viruses, but this needs up to a few hours to bind sufficient fluorescence dyes to viruses for detection. In this paper, we developed a mist-labeling can detect substitution viruses in a short time to improve the binding rate of fluorescent dyes and substitution viruses by the micro reaction process. Moreover, we developed the rapid detection system with the above 'mist labeling'. The detection system set with a sampling bag collecting patient’s breath and a cartridge can detect automatically pathogens within 10 minutes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=viruses" title="viruses">viruses</a>, <a href="https://publications.waset.org/abstracts/search?q=sampler" title=" sampler"> sampler</a>, <a href="https://publications.waset.org/abstracts/search?q=mist" title=" mist"> mist</a>, <a href="https://publications.waset.org/abstracts/search?q=detection" title=" detection"> detection</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescent%20dyes" title=" fluorescent dyes"> fluorescent dyes</a>, <a href="https://publications.waset.org/abstracts/search?q=microreaction" title=" microreaction"> microreaction</a> </p> <a href="https://publications.waset.org/abstracts/2700/rapid-detection-system-of-airborne-pathogens" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2700.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">475</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Chatter Suppression in Boring Process Using Passive Damper</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=V.%20Prasannavenkadesan">V. Prasannavenkadesan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Elango"> A. Elango</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Chockalingam"> S. Chockalingam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> During machining process, chatter is an unavoidable phenomenon. Boring bars possess the cantilever shape and due to this, it is subjected to chatter. The adverse effect of chatter includes the increase in temperature which will leads to excess tool wear. To overcome these problems, in this investigation, Cartridge brass (Cu – 70% and Zn – 30%) is passively fixed on the boring bar and also clearance is provided in order to reduce the displacement, tool wear and cutting temperature. A conventional all geared lathe is attached with vibrometer and pyrometer is used to measure the displacement and temperature. The influence of input parameters such as cutting speed, depth of cut and clearance on temperature, tool wear and displacement are investigated for various cutting conditions. From the result, the optimum conditions to obtain better damping in boring process for chatter reduction is identified. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=boring" title="boring">boring</a>, <a href="https://publications.waset.org/abstracts/search?q=chatter" title=" chatter"> chatter</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20damping" title=" mass damping"> mass damping</a>, <a href="https://publications.waset.org/abstracts/search?q=passive%20damping" title=" passive damping"> passive damping</a> </p> <a href="https://publications.waset.org/abstracts/40957/chatter-suppression-in-boring-process-using-passive-damper" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40957.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">350</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> The Influence of the Moving Speeds of DNA Droplet on Polymerase Chain Reaction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jyh%20Jyh%20Chen">Jyh Jyh Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Fu%20H.%20Yang"> Fu H. Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chen%20W.%20Wang"> Chen W. Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu%20M.%20Lin"> Yu M. Lin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this work, a reaction chamber is reciprocated among three temperature regions by using an oscillatory thermal cycling machine. Three cartridge heaters are collocated to heat three aluminum blocks in order to achieve PCR requirements in the reaction chamber. The effects of various chamber moving speeds among different temperature regions on the chamber temperature profiles are presented. To solve the evaporation effect of the sample in the PCR experiment, the mineral oil and the cover lid are used. The influences of various extension times on DNA amplification are also demonstrated. The target fragments of the amplification are 385-bp and 420-bp. The results show when the forward speed is set at 6 mm/s and the backward speed is 2.4 mm/s, the temperature required for the experiment can be achieved. It is successful to perform the amplification of DNA fragments in our device. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oscillatory" title="oscillatory">oscillatory</a>, <a href="https://publications.waset.org/abstracts/search?q=polymerase%20chain%20reaction" title=" polymerase chain reaction"> polymerase chain reaction</a>, <a href="https://publications.waset.org/abstracts/search?q=reaction%20chamber" title=" reaction chamber"> reaction chamber</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20cycling%20machine" title=" thermal cycling machine"> thermal cycling machine</a> </p> <a href="https://publications.waset.org/abstracts/64588/the-influence-of-the-moving-speeds-of-dna-droplet-on-polymerase-chain-reaction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64588.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">530</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Comparison of Nucleic Acid Extraction Platforms On Tissue Samples</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Siti%20Rafeah%20Md%20Rafei">Siti Rafeah Md Rafei</a>, <a href="https://publications.waset.org/abstracts/search?q=Karen%20Wang%20Yanping"> Karen Wang Yanping</a>, <a href="https://publications.waset.org/abstracts/search?q=Park%20Mi%20Kyoung"> Park Mi Kyoung</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tissue samples are precious supply for molecular studies or disease identification diagnosed using molecular assays, namely real-time PCR (qPCR). It is critical to establish the most favorable nucleic acid extraction that gives the PCR-amplifiable genomic DNA. Furthermore, automated nucleic acid extraction is an appealing alternative to labor-intensive manual methods. Operational complexity, defined as the number of steps required to obtain an extracted sample, is one of the criteria in the comparison. Here we are comparing the One BioMed’s automated X8 platform with the commercially available manual-operated kits from QIAGEN Mini Kit and Roche. We extracted DNA from rat fresh-frozen tissue (from different type of organs) in the matrices. After tissue pre-treatment, it is added to the One BioMed’s X8 pre-filled cartridge, and the QIAGEN QIAmp column respectively. We found that the results after subjecting the eluates to the Real Time PCR using BIORAD CFX are comparable. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DNA%20extraction" title="DNA extraction">DNA extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=frozen%20tissue" title=" frozen tissue"> frozen tissue</a>, <a href="https://publications.waset.org/abstracts/search?q=PCR" title=" PCR"> PCR</a>, <a href="https://publications.waset.org/abstracts/search?q=qPCR" title=" qPCR"> qPCR</a>, <a href="https://publications.waset.org/abstracts/search?q=rat" title=" rat"> rat</a> </p> <a href="https://publications.waset.org/abstracts/153546/comparison-of-nucleic-acid-extraction-platforms-on-tissue-samples" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153546.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">160</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Development of Adaptive Proportional-Integral-Derivative Feeding Mechanism for Robotic Additive Manufacturing System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Andy%20Alubaidy">Andy Alubaidy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this work, a robotic additive manufacturing system (RAMS) that is capable of three-dimensional (3D) printing in six degrees of freedom (DOF) with very high accuracy and virtually on any surface has been designed and built. One of the major shortcomings in existing 3D printer technology is the limitation to three DOF, which results in prolonged fabrication time. Depending on the techniques used, it usually takes at least two hours to print small objects and several hours for larger objects. Another drawback is the size of the printed objects, which is constrained by the physical dimensions of most low-cost 3D printers, which are typically small. In such cases, large objects are produced by dividing them into smaller components that fit the printer’s workable area. They are then glued, bonded or otherwise attached to create the required object. Another shortcoming is material constraints and the need to fabricate a single part using different materials. With the flexibility of a six-DOF robot, the RAMS has been designed to overcome these problems. A feeding mechanism using an adaptive Proportional-Integral-Derivative (PID) controller is utilized along with a national instrument compactRIO (NI cRIO), an ABB robot, and off-the-shelf sensors. The RAMS have the ability to 3D print virtually anywhere in six degrees of freedom with very high accuracy. It is equipped with an ABB IRB 120 robot to achieve this level of accuracy. In order to convert computer-aided design (CAD) files to digital format that is acceptable to the robot, Hypertherm Robotic Software Inc.’s state-of-the-art slicing software called “ADDMAN” is used. ADDMAN is capable of converting any CAD file into RAPID code (the programing language for ABB robots). The robot uses the generated code to perform the 3D printing. To control the entire process, National Instrument (NI) compactRIO (cRio 9074), is connected and communicated with the robot and a feeding mechanism that is designed and fabricated. The feeding mechanism consists of two major parts, cold-end and hot-end. The cold-end consists of what is conventionally known as an extruder. Typically, a stepper-motor is used to control the push on the material, however, for optimum control, a DC motor is used instead. The hot-end consists of a melt-zone, nozzle, and heat-brake. The melt zone ensures a thorough melting effect and consistent output from the nozzle. Nozzles are made of brass for thermo-conductivity while the melt-zone is comprised of a heating block and a ceramic heating cartridge to transfer heat to the block. The heat-brake ensures that there is no heat creep-up effect as this would swell the material and prevent consistent extrusion. A control system embedded in the cRio is developed using NI Labview which utilizes adaptive PID to govern the heating cartridge in conjunction with a thermistor. The thermistor sends temperature feedback to the cRio, which will issue heat increase or decrease based on the system output. Since different materials have different melting points, our system will allow us to adjust the temperature and vary the material. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=robotic" title="robotic">robotic</a>, <a href="https://publications.waset.org/abstracts/search?q=additive%20manufacturing" title=" additive manufacturing"> additive manufacturing</a>, <a href="https://publications.waset.org/abstracts/search?q=PID%20controller" title=" PID controller"> PID controller</a>, <a href="https://publications.waset.org/abstracts/search?q=cRIO" title=" cRIO"> cRIO</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title=" 3D printing"> 3D printing</a> </p> <a href="https://publications.waset.org/abstracts/57980/development-of-adaptive-proportional-integral-derivative-feeding-mechanism-for-robotic-additive-manufacturing-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/57980.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">217</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Advantages of Matrix Solid Phase Dispersive (MSPD) Extraction Associated to MIPS versus MAE Liquid Extraction for the Simultaneous Analysis of PAHs, PCBs and Some Hydroxylated PAHs in Sediments</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=F.%20Portet-Koltalo">F. Portet-Koltalo</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Tian"> Y. Tian</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Berger"> I. Berger</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Boulanger-Lecomte"> C. Boulanger-Lecomte</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Benamar"> A. Benamar</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Machour"> N. Machour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sediments are complex environments which can accumulate a great variety of persistent toxic contaminants such as polychlorobiphenyles (PCBs), polycyclic aromatic hydrocarbons (PAHs) and some of their more toxic degradation metabolites such as hydroxylated PAHs (OH-PAHs). Owing to their composition, fine clayey sediments can be more difficult to extract than soils using conventional solvent extraction processes. So this study aimed to compare the potential of MSPD (matrix solid phase dispersive extraction) to extract PCBs, PAHs and OH-PAHs, in comparison with microwave assisted extraction (MAE). Methodologies: MAE extraction with various solvent mixtures was used to extract PCBs, PAHs and OH-PAHs from sediments in two runs, followed by two GC-MS analyses. MSPD consisted in crushing the dried sediment with dispersive agents, introducing the mixture in cartridges and eluting the target compounds with an appropriate volume of selected solvents. So MSPD combined with cartridges containing MIPs (molecularly imprinted polymers) designed for OH-PAHs was used to extract the three families of target compounds in only one run, followed by parallel analyses in GC-MS for PAHs/PCBs and HPLC-FLD for OH-PAHs. Results: MAE extraction was optimized to extract from clayey sediments, in two runs, PAHs/PCBs in one hand and OH-PAHs in the other hand. Indeed, the best conditions of extractions (mixtures of extracting solvents, temperature) were different if we consider the polarity and the thermodegradability of the different families of target contaminants: PAHs/PCBs were better extracted using an acetone/toluene 50/50 mixture at 130°C whereas OH-PAHs were better extracted using an acetonitrile/toluene 90/10 mixture at 100°C. Moreover, the two consecutive GC-MS analyses contributed to double the total analysis time. A matrix solid phase dispersive (MSPD) extraction procedure was also optimized, with the first objective of increasing the extraction recovery yields of PAHs and PCBs from fine-grained sediment. The crushing time (2-10 min), the nature of the dispersing agents added for purifying and increasing the extraction yields (Florisil, octadecylsilane, 3-chloropropyle, 4-benzylchloride), the nature and the volume of eluting solvents (methylene chloride, hexane, hexane/acetone…) were studied. It appeared that in the best conditions, MSPD was a better extraction method than MAE for PAHs and PCBs, with respectively, mean increases of 8.2% and 71%. This method was also faster, easier and less expensive. But the other advantage of MSPD was that it allowed to introduce easily, just after the first elution process of PAHs/PCBs, a step permitting the selective recovery of OH-PAHs. A cartridge containing MIPs designed for phenols was coupled to the cartridge containing the dispersed sediment, and various eluting solvents, different from those used for PAHs and PCBs, were tested to selectively concentrate and extract OH-PAHs. Thereafter OH-PAHs could be analyzed at the same time than PAHs and PCBs: the OH-PAH extract could be analyzed with HPLC-FLD, whereas the PAHs/PCBs extract was analyzed with GC-MS, adding only few minutes more to the total duration of the analytical process. Conclusion: MSPD associated to MIPs appeared to be an easy, fast and low expensive method, able to extract in one run a complex mixture of toxic apolar and more polar contaminants present in clayey fine-grained sediments, an environmental matrix which is generally difficult to analyze. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=contaminated%20fine-grained%20sediments" title="contaminated fine-grained sediments">contaminated fine-grained sediments</a>, <a href="https://publications.waset.org/abstracts/search?q=matrix%20solid%20phase%20dispersive%20extraction" title=" matrix solid phase dispersive extraction"> matrix solid phase dispersive extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave%20assisted%20extraction" title=" microwave assisted extraction"> microwave assisted extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=molecularly%20imprinted%20polymers" title=" molecularly imprinted polymers"> molecularly imprinted polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-pollutant%20analysis" title=" multi-pollutant analysis"> multi-pollutant analysis</a> </p> <a href="https://publications.waset.org/abstracts/48037/advantages-of-matrix-solid-phase-dispersive-mspd-extraction-associated-to-mips-versus-mae-liquid-extraction-for-the-simultaneous-analysis-of-pahs-pcbs-and-some-hydroxylated-pahs-in-sediments" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48037.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">353</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Performance of Flat Plate Loop Heat Pipe for Thermal Management of Lithium-Ion Battery in Electric Vehicle Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bambang%20Ariantara">Bambang Ariantara</a>, <a href="https://publications.waset.org/abstracts/search?q=Nandy%20Putra"> Nandy Putra</a>, <a href="https://publications.waset.org/abstracts/search?q=Rangga%20Aji%20Pamungkas"> Rangga Aji Pamungkas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of electric vehicle batteries has resulted in very high energy density lithium-ion batteries. However, this progress is accompanied by the risk of thermal runaway, which can result in serious accidents. Heat pipes are heat exchangers that are suitable to be applied in electric vehicle battery thermal management for their lightweight, compact size and do not require external power supply. This paper aims to examine experimentally a flat plate loop heat pipe (FPLHP) performance as a heat exchanger in the thermal management system of the lithium-ion battery for electric vehicle application. The heat generation of the battery was simulated using a cartridge heater. Stainless steel screen mesh was used as the capillary wick. Distilled water, alcohol and acetone were used as working fluids with a filling ratio of 60%. It was found that acetone gives the best performance that produces the thermal resistance of 0.22 W/°C with 50 °C evaporator temperature at heat flux load of 1.61 W/cm2. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=electric%20vehicle" title="electric vehicle">electric vehicle</a>, <a href="https://publications.waset.org/abstracts/search?q=flat-plate%20loop%20heat%20pipe" title=" flat-plate loop heat pipe"> flat-plate loop heat pipe</a>, <a href="https://publications.waset.org/abstracts/search?q=lithium-ion%20battery" title=" lithium-ion battery"> lithium-ion battery</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20management%20system" title=" thermal management system"> thermal management system</a> </p> <a href="https://publications.waset.org/abstracts/30606/performance-of-flat-plate-loop-heat-pipe-for-thermal-management-of-lithium-ion-battery-in-electric-vehicle-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30606.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">351</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Braille Lab: A New Design Approach for Social Entrepreneurship and Innovation in Assistive Tools for the Visually Impaired</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Claudio%20Loconsole">Claudio Loconsole</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniele%20Leonardis"> Daniele Leonardis</a>, <a href="https://publications.waset.org/abstracts/search?q=Antonio%20Brunetti"> Antonio Brunetti</a>, <a href="https://publications.waset.org/abstracts/search?q=Gianpaolo%20Francesco%20Trotta"> Gianpaolo Francesco Trotta</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicholas%20Caporusso"> Nicholas Caporusso</a>, <a href="https://publications.waset.org/abstracts/search?q=Vitoantonio%20Bevilacqua"> Vitoantonio Bevilacqua</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Unfortunately, many people still do not have access to communication, with specific regard to reading and writing. Among them, people who are blind or visually impaired, have several difficulties in getting access to the world, compared to the sighted. Indeed, despite technology advancement and cost reduction, nowadays assistive devices are still expensive such as Braille-based input/output systems which enable reading and writing texts (e.g., personal notes, documents). As a consequence, assistive technology affordability is fundamental in supporting the visually impaired in communication, learning, and social inclusion. This, in turn, has serious consequences in terms of equal access to opportunities, freedom of expression, and actual and independent participation to a society designed for the sighted. Moreover, the visually impaired experience difficulties in recognizing objects and interacting with devices in any activities of daily living. It is not a case that Braille indications are commonly reported only on medicine boxes and elevator keypads. Several software applications for the automatic translation of written text into speech (e.g., Text-To-Speech - TTS) enable reading pieces of documents. However, apart from simple tasks, in many circumstances TTS software is not suitable for understanding very complicated pieces of text requiring to dwell more on specific portions (e.g., mathematical formulas or Greek text). In addition, the experience of reading\writing text is completely different both in terms of engagement, and from an educational perspective. Statistics on the employment rate of blind people show that learning to read and write provides the visually impaired with up to 80% more opportunities of finding a job. Especially in higher educational levels, where the ability to digest very complex text is key, accessibility and availability of Braille plays a fundamental role in reducing drop-out rate of the visually impaired, thus affecting the effectiveness of the constitutional right to get access to education. In this context, the Braille Lab project aims at overcoming these social needs by including affordability in designing and developing assistive tools for visually impaired people. In detail, our awarded project focuses on a technology innovation of the operation principle of existing assistive tools for the visually impaired leaving the Human-Machine Interface unchanged. This can result in a significant reduction of the production costs and consequently of tool selling prices, thus representing an important opportunity for social entrepreneurship. The first two assistive tools designed within the Braille Lab project following the proposed approach aims to provide the possibility to personally print documents and handouts and to read texts written in Braille using refreshable Braille display, respectively. The former, named ‘Braille Cartridge’, represents an alternative solution for printing in Braille and consists in the realization of an electronic-controlled dispenser printing (cartridge) which can be integrated within traditional ink-jet printers, in order to leverage the efficiency and cost of the device mechanical structure which are already being used. The latter, named ‘Braille Cursor’, is an innovative Braille display featuring a substantial technology innovation by means of a unique cursor virtualizing Braille cells, thus limiting the number of active pins needed for Braille characters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Human%20rights" title="Human rights">Human rights</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20challenges%20and%20technology%20innovations" title=" social challenges and technology innovations"> social challenges and technology innovations</a>, <a href="https://publications.waset.org/abstracts/search?q=visually%20impaired" title=" visually impaired"> visually impaired</a>, <a href="https://publications.waset.org/abstracts/search?q=affordability" title=" affordability"> affordability</a>, <a href="https://publications.waset.org/abstracts/search?q=assistive%20tools" title=" assistive tools"> assistive tools</a> </p> <a href="https://publications.waset.org/abstracts/70390/braille-lab-a-new-design-approach-for-social-entrepreneurship-and-innovation-in-assistive-tools-for-the-visually-impaired" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/70390.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> New Off-Line SPE-GC-MS/MS Method for Determination of Mineral Oil Saturated Hydrocarbons/Mineral Oil Hydrocarbons in Animal Feed, Foods, Infant Formula and Vegetable Oils</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ovanes%20Chakoyan">Ovanes Chakoyan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> MOH (mineral oil hydrocarbons), which consist of mineral oil saturated hydrocarbons(MOSH) and mineral oil aromatic hydrocarbons(MOAH), are present in various products such as vegetable oils, animal feed, foods, and infant formula. Contamination of foods with mineral oil hydrocarbons, particularly mineral oil aromatic hydrocarbons(MOAH), exhibiting carcinogenic, mutagenic, and hormone-disruptive effects. Identifying toxic substances among the many thousands comprising mineral oils in food samples is a difficult analytical challenge. A method based on an offline-solid phase extraction approach coupled with gas chromatography-triple quadrupole(GC-MS/MS) was developed for the determination of MOSH/MOAH in various products such as vegetable oils, animal feed, foods, and infant formula. A glass solid phase extraction cartridge loaded with 7 g of activated silica gel impregnated with 10 % silver nitrate for removal of olefins and lipids. The MOSH/MOAH fractions were eluated with hexane and hexane: dichloromethane : toluene, respectively. Each eluate was concentrated to 50 µl in toluene and injected on splitless mode into GC-MS/MS. Accuracy of the method was estimated as measurement of recovery of spiked oil samples at 2.0, 15.0, and 30.0 mg kg -1, and recoveries varied from 85 to 105 %. The method was applied to the different types of samples (sunflower meal, chocolate ships, santa milk chocolate, biscuits, infant milk, cornflakes, refined sunflower oil, crude sunflower oil), detecting MOSH up to 56 mg/kg and MOAH up to 5 mg/kg. The limit of quantification(LOQ) of the proposed method was estimated at 0.5 mg/kg and 0.3 mg/kg for MOSH and MOAH, respectively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MOSH" title="MOSH">MOSH</a>, <a href="https://publications.waset.org/abstracts/search?q=MOAH" title=" MOAH"> MOAH</a>, <a href="https://publications.waset.org/abstracts/search?q=GC-MS%2FMS" title=" GC-MS/MS"> GC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=foods" title=" foods"> foods</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20phase%20extraction" title=" solid phase extraction"> solid phase extraction</a> </p> <a href="https://publications.waset.org/abstracts/162923/new-off-line-spe-gc-msms-method-for-determination-of-mineral-oil-saturated-hydrocarbonsmineral-oil-hydrocarbons-in-animal-feed-foods-infant-formula-and-vegetable-oils" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/162923.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">86</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Chemical Warfare Agent Simulant by Photocatalytic Filtering Reactor: Effect of Operating Parameters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Youcef%20Serhane">Youcef Serhane</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdelkrim%20Bouzaza"> Abdelkrim Bouzaza</a>, <a href="https://publications.waset.org/abstracts/search?q=Dominique%20Wolbert"> Dominique Wolbert</a>, <a href="https://publications.waset.org/abstracts/search?q=Aymen%20Amin%20Assadi"> Aymen Amin Assadi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Throughout history, the use of chemical weapons is not exclusive to combats between army corps; some of these weapons are also found in very targeted intelligence operations (political assassinations), organized crime, and terrorist organizations. To improve the speed of action, important technological devices have been developed in recent years, in particular in the field of protection and decontamination techniques to better protect and neutralize a chemical threat. In order to assess certain protective, decontaminating technologies or to improve medical countermeasures, tests must be conducted. In view of the great toxicity of toxic chemical agents from (real) wars, simulants can be used, chosen according to the desired application. Here, we present an investigation about using a photocatalytic filtering reactor (PFR) for highly contaminated environments containing diethyl sulfide (DES). This target pollutant is used as a simulant of CWA, namely of Yperite (Mustard Gas). The influence of the inlet concentration (until high concentrations of DES (1200 ppmv, i.e., 5 g/m³ of air) has been studied. Also, the conversion rate was monitored under different relative humidity and different flow rates (respiratory flow - standards: ISO / DIS 8996 and NF EN 14387 + A1). In order to understand the efficacity of pollutant neutralization by PFR, a kinetic model based on the Langmuir–Hinshelwood (L–H) approach and taking into account the mass transfer step was developed. This allows us to determine the adsorption and kinetic degradation constants with no influence of mass transfer. The obtained results confirm that this small configuration of reactor presents an extremely promising way for the use of photocatalysis for treatment to deal with highly contaminated environments containing real chemical warfare agents. Also, they can give birth to an individual protection device (an autonomous cartridge for a gas mask). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=photocatalysis" title="photocatalysis">photocatalysis</a>, <a href="https://publications.waset.org/abstracts/search?q=photocatalytic%20filtering%20reactor" title=" photocatalytic filtering reactor"> photocatalytic filtering reactor</a>, <a href="https://publications.waset.org/abstracts/search?q=diethylsulfide" title=" diethylsulfide"> diethylsulfide</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20warfare%20agents" title=" chemical warfare agents"> chemical warfare agents</a> </p> <a href="https://publications.waset.org/abstracts/124989/chemical-warfare-agent-simulant-by-photocatalytic-filtering-reactor-effect-of-operating-parameters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/124989.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">105</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> A Multi-Family Offline SPE LC-MS/MS Analytical Method for Anionic, Cationic and Non-ionic Surfactants in Surface Water</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Laure%20Wiest">Laure Wiest</a>, <a href="https://publications.waset.org/abstracts/search?q=Barbara%20Giroud"> Barbara Giroud</a>, <a href="https://publications.waset.org/abstracts/search?q=Azziz%20Assoumani"> Azziz Assoumani</a>, <a href="https://publications.waset.org/abstracts/search?q=Francois%20Lestremau"> Francois Lestremau</a>, <a href="https://publications.waset.org/abstracts/search?q=Emmanuelle%20Vulliet"> Emmanuelle Vulliet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to their production at high tonnages and their extensive use, surfactants are contaminants among those determined at the highest concentrations in wastewater. However, analytical methods and data regarding their occurrence in river water are scarce and concern only a few families, mainly anionic surfactants. The objective of this study was to develop an analytical method to extract and analyze a wide variety of surfactants in a minimum of steps, with a sensitivity compatible with the detection of ultra-traces in surface waters. 27 substances, from 12 families of surfactants, anionic, cationic and non-ionic were selected for method optimization. Different retention mechanisms for the extraction by solid phase extraction (SPE) were tested and compared in order to improve their detection by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The best results were finally obtained with a C18 grafted silica LC column and a polymer cartridge with hydrophilic lipophilic balance (HLB), and the method developed allows the extraction of the three types of surfactants with satisfactory recoveries. The final analytical method comprised only one extraction and two LC injections. It was validated and applied for the quantification of surfactants in 36 river samples. The method's limits of quantification (LQ), intra- and inter-day precision and accuracy were evaluated, and good performances were obtained for the 27 substances. As these compounds have many areas of application, contaminations of instrument and method blanks were observed and considered for the determination of LQ. Nevertheless, with LQ between 15 and 485 ng/L, and accuracy of over 80%, this method was suitable for monitoring surfactants in surface waters. Application on French river samples revealed the presence of anionic, cationic and non-ionic surfactants with median concentrations ranging from 24 ng/L for octylphenol ethoxylates (OPEO) to 4.6 µg/L for linear alkylbenzenesulfonates (LAS). The analytical method developed in this work will therefore be useful for future monitoring of surfactants in waters. Moreover, this method, which shows good performances for anionic, non-ionic and cationic surfactants, may be easily adapted to other surfactants. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anionic%20surfactant" title="anionic surfactant">anionic surfactant</a>, <a href="https://publications.waset.org/abstracts/search?q=cationic%20surfactant" title=" cationic surfactant"> cationic surfactant</a>, <a href="https://publications.waset.org/abstracts/search?q=LC-MS%2FMS" title=" LC-MS/MS"> LC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=non-ionic%20surfactant" title=" non-ionic surfactant"> non-ionic surfactant</a>, <a href="https://publications.waset.org/abstracts/search?q=SPE" title=" SPE"> SPE</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20water" title=" surface water"> surface water</a> </p> <a href="https://publications.waset.org/abstracts/134440/a-multi-family-offline-spe-lc-msms-analytical-method-for-anionic-cationic-and-non-ionic-surfactants-in-surface-water" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/134440.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">145</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> New Drug Discoveries and Packaging Challenges</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anupam%20Chanda">Anupam Chanda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Presently Packaging plays a significant role for drug discoveries. The process of selecting materials and the type of packaging also offers an opportunity for the Packaging scientist to look for biological delivery choices. Most injectable protein products were supplied in some sort of glass vial, prefilled syringe, cartridge. Those product having high Ph content there is a chance of “delamination “from inner surface of glass vial. With protein-based drugs, the biggest issue is the effect of packaging derivatives on the protein’s threedimensional and surface structure. These are any effects that relate to denaturation or aggregation of the protein due to oxidation or interactions from contaminants or impurities in the preparation. The potential for these effects needs to be carefully considered in choosing the container and the container closure system to avoid putting patients in jeopardy. Cause of Delamination : -Formulations with a high pH include phosphate and citrate buffers increase the risk of glass delamination. -High alkali content in glass could accelerate erosion. -High temperature during the vial-forming process increase the risk of glass delamination. -Terminal sterilization (irradiated at 20-40 kGy for 150 min) also is a risk factor for specific products(veterinary parenteral administration),could cause delamination. -High product-storage temperatures and long exposure times can increase the rate and severity of glass delamination. How to prevent Delamination -Treating the surface of the glass vials with materials, such as ammonium sulfate or siliconization can reduce the rate of glass erosion. -Consider alternative sterilization methods only in rare cases. -The correct specification for the glass to ensure its suitability for the pH of the product. -Use Cyclic olefin copolymer(COC)/Cyclic olefin Polymer(COP) Adsorption of protein and Solutions: Option#1 Coat with linear methoxylated polyglycerol and hyperbranchedmethoxylated polyglycerol. Option#2 Thehyperbranched non-methoxylated coating performed best. Option#3 Coat with hyperbranched polyglycerol Option#4 Right selection of Sterilization of glass vial/syringe. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=delamination%20of%20glass" title="delamination of glass">delamination of glass</a>, <a href="https://publications.waset.org/abstracts/search?q=ptrotien%20adoptions%20inside%20the%20glass%20surface" title=" ptrotien adoptions inside the glass surface"> ptrotien adoptions inside the glass surface</a>, <a href="https://publications.waset.org/abstracts/search?q=extractable%20%26%20leachable%20solutions" title=" extractable &amp; leachable solutions"> extractable &amp; leachable solutions</a>, <a href="https://publications.waset.org/abstracts/search?q=injectable%20designs%20for%20new%20drugs" title=" injectable designs for new drugs"> injectable designs for new drugs</a> </p> <a href="https://publications.waset.org/abstracts/159853/new-drug-discoveries-and-packaging-challenges" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159853.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Development of Beeswax-Discharge Writing Material for Visually Impaired Persons</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Doi">K. Doi</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Nishimura"> T. Nishimura</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Fujimoto"> H. Fujimoto</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Tanaka"> T. Tanaka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> It has been known that visually impaired persons have some problems in getting visual information. Therefore, information accessibility for the visually impaired persons is very important in a current information society. Some application software with read-aloud function for using personal computer and smartphone are getting more and more popular among visually impaired persons in the world. On the other hand, it is also very important for being able to learn how to read and write characters such as Braille and Visual character. Braille typewriter has been widely used in learning Braille. And also raised-line drawing kits as writing material has been used for decades for especially acquired visually impaired persons. However, there are some drawbacks such as the drawn line cannot be erased. Moreover, visibility of drawing lines is not so good for visually impaired with low vision. We had significant number of requests for developing new writing material for especially acquired visually impaired persons instead of raised-line drawing kits. For conducting development research of novel writing material, we could receive a research grant from ministry of health, labor and welfare in Japanese government. In this research, we developed writing material typed pens and pencils with Beeswax-discharge instead of conventional raised-line drawing kits. This writing material was equipped with cartridge heater for melting beeswax and its heat controller. When this pen users held down the pen tip on the regular paper such as fine paper and so on, the melted beeswax could be discharged from pen tip with valve structure. The beeswax was discharged at 100 gf of holding down force based on results of our previous trial study. The shape of pen tip was semispherical for becoming low friction between pen tip and surface of paper. We conducted one basic experiment to evaluate influence of the curvature of pen tip on ease to write. Concretely, the conditions of curvature was 0.15, 0.35, 0.50, 1.00 mm. The following four interval scales were used as indexes of subjective assessment during writing such as feeling of smooth motion of pen, feeling of comfortable writing, sense of security and feeling of writing fatigue. Ten subjects were asked to participate in this experiment. The results reveal that subjects could draw easily when the radius of the pen tip was 1.00 mm, and lines drawn with beeswax-discharge writing material were easy to perceive. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=beeswax-discharge%20writing%20material" title="beeswax-discharge writing material">beeswax-discharge writing material</a>, <a href="https://publications.waset.org/abstracts/search?q=raised-line%20drawing%20kits" title=" raised-line drawing kits"> raised-line drawing kits</a>, <a href="https://publications.waset.org/abstracts/search?q=visually%20impaired%20persons" title=" visually impaired persons"> visually impaired persons</a>, <a href="https://publications.waset.org/abstracts/search?q=pen%20tip" title=" pen tip"> pen tip</a> </p> <a href="https://publications.waset.org/abstracts/75003/development-of-beeswax-discharge-writing-material-for-visually-impaired-persons" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75003.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Effective Apixaban Clearance with Cytosorb Extracorporeal Hemoadsorption</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Klazina%20T.%20Havinga">Klazina T. Havinga</a>, <a href="https://publications.waset.org/abstracts/search?q=Hilde%20R.%20H.%20de%20Geus"> Hilde R. H. de Geus</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Pre-operative coagulation management of Apixaban prescribed patients, a new oral anticoagulant (a factor Xa inhibitor), is difficult, especially when chronic kidney disease (CKD) causes drug overdose. Apixaban is not dialyzable due to its high level of protein binding. An antidote, Andexanet α, is available but expensive and has an unfavorable short half-life. We report the successful extracorporeal removal of Apixaban prior to emergency surgery with the CytoSorb® Hemoadsorption device. Methods: A 89-year-old woman with CKD, with an Apixaban prescription for atrial fibrillation, was presented at the ER with traumatic rib fractures, a flail chest, and an unstable spinal fracture (T12) for which emergency surgery was indicated. However, due to very high Apixaban levels, this surgery had to be postponed. Based on the Apixaban-specific anti-factor Xa activity (AFXaA) measurements at admission and 10 hours later, complete clearance was expected after 48 hours. In order to enhance the Apixaban removal and reduce the time to operation, and therefore reduce pulmonary complications, CRRT with CytoSorb® cartridge was initiated. Apixaban-specific anti-factor Xa activity (AFXaA) was measured frequently as a substitute for Apixaban drug concentrations, pre- and post adsorber, in order to calculate the adsorber-related clearance. Results: The admission AFXaA concentration, as a substitute for Apixaban drug levels, was 218 ng/ml, which decreased to 157 ng/ml after ten hours. Due to sustained anticoagulation effects, surgery was again postponed. However, the AFXaA levels decreased quickly to sub-therapeutic levels after CRRT (Multifiltrate Pro, Fresenius Medical Care, Blood flow 200 ml/min, Dialysate Flow 4000 ml/h, Prescribed renal dose 51 ml-kg-h) with Cytosorb® connected in series into the circuit was initiated (within 5 hours). The adsorber-related (indirect) Apixaban clearance was calculated every half hour (Cl=Qe * (AFXaA pre- AFXaA post/ AFXaA pre) with Qe=plasma flow rate calculated with Ht=0.38 and system blood flow rate 200 ml-min): 100 ml/min, 72 ml/min and 57 ml/min. Although, as expected, the adsorber-related clearance decreased quickly due to saturation of the beads, still the reduction rate achieved resulted in a very rapid decrease in AFXaA levels. Surgery was ordered and possible within 5 hours after Cytosorb initiation. Conclusion: The CytoSorb® Hemoadsorption device enabled rapid correction of Apixaban associated anticoagulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Apixaban" title="Apixaban">Apixaban</a>, <a href="https://publications.waset.org/abstracts/search?q=CytoSorb" title=" CytoSorb"> CytoSorb</a>, <a href="https://publications.waset.org/abstracts/search?q=emergency%20surgery" title=" emergency surgery"> emergency surgery</a>, <a href="https://publications.waset.org/abstracts/search?q=Hemoadsorption" title=" Hemoadsorption"> Hemoadsorption</a> </p> <a href="https://publications.waset.org/abstracts/152958/effective-apixaban-clearance-with-cytosorb-extracorporeal-hemoadsorption" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152958.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">156</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Heat Transfer Performance of a Small Cold Plate with Uni-Directional Porous Copper for Cooling Power Electronics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=K.%20Yuki">K. Yuki</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Tsuji"> R. Tsuji</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Takai"> K. Takai</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Aramaki"> S. Aramaki</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Kibushi"> R. Kibushi</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Unno"> N. Unno</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Suzuki"> K. Suzuki</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A small cold plate with uni-directional porous copper is proposed for cooling power electronics such as an on-vehicle inverter with the heat generation of approximately 500 W/cm2. The uni-directional porous copper with the pore perpendicularly orienting the heat transfer surface is soldered to a grooved heat transfer surface. This structure enables the cooling liquid to evaporate in the pore of the porous copper and then the vapor to discharge through the grooves. In order to minimize the cold plate, a double flow channel concept is introduced for the design of the cold plate. The cold plate consists of a base plate, a spacer, and a vapor discharging plate, totally 12 mm in thickness. The base plate has multiple nozzles of 1.0 mm in diameter for the liquid supply and 4 slits of 2.0 mm in width for vapor discharging, and is attached onto the top surface of the porous copper plate of 20 mm in diameter and 5.0 mm in thickness. The pore size is 0.36 mm and the porosity is 36 %. The cooling liquid flows into the porous copper as an impinging jet flow from the multiple nozzles, and then the vapor, which is generated in the pore, is discharged through the grooves and the vapor slits outside the cold plate. A heated test section consists of the cold plate, which was explained above, and a heat transfer copper block with 6 cartridge heaters. The cross section of the heat transfer block is reduced in order to increase the heat flux. The top surface of the block is the grooved heat transfer surface of 10 mm in diameter at which the porous copper is soldered. The grooves are fabricated like latticework, and the width and depth are 1.0 mm and 0.5 mm, respectively. By embedding three thermocouples in the cylindrical part of the heat transfer block, the temperature of the heat transfer surface ant the heat flux are extrapolated in a steady state. In this experiment, the flow rate is 0.5 L/min and the flow velocity at each nozzle is 0.27 m/s. The liquid inlet temperature is 60 °C. The experimental results prove that, in a single-phase heat transfer regime, the heat transfer performance of the cold plate with the uni-directional porous copper is 2.1 times higher than that without the porous copper, though the pressure loss with the porous copper also becomes higher than that without the porous copper. As to the two-phase heat transfer regime, the critical heat flux increases by approximately 35% by introducing the uni-directional porous copper, compared with the CHF of the multiple impinging jet flow. In addition, we confirmed that these heat transfer data was much higher than that of the ordinary single impinging jet flow. These heat transfer data prove high potential of the cold plate with the uni-directional porous copper from the view point of not only the heat transfer performance but also energy saving. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cooling" title="cooling">cooling</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20plate" title=" cold plate"> cold plate</a>, <a href="https://publications.waset.org/abstracts/search?q=uni-porous%20media" title=" uni-porous media"> uni-porous media</a>, <a href="https://publications.waset.org/abstracts/search?q=heat%20transfer" title=" heat transfer"> heat transfer</a> </p> <a href="https://publications.waset.org/abstracts/74838/heat-transfer-performance-of-a-small-cold-plate-with-uni-directional-porous-copper-for-cooling-power-electronics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/74838.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Variation of Biologically Active Compounds and Antioxidancy in the Process of Blueberry Storage</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meri%20Khakhutaishvili">Meri Khakhutaishvili</a>, <a href="https://publications.waset.org/abstracts/search?q=Indira%20Djaparidze"> Indira Djaparidze</a>, <a href="https://publications.waset.org/abstracts/search?q=Maia%20Vanidze"> Maia Vanidze</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleko%20Kalandia"> Aleko Kalandia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cultivation of blueberry in Georgia started in 21st century. There are more than 20 species of blueberry cultivated in this region from all other the world. The species are mostly planted on acidic soil, previously occupied by tea plantations. Many of the plantations have pretty good yield. It is known that changing the location of a plant to a new soil or climate effects chemical compositions of the plant. However, even though these plants are brought from other countries, no research has been conducted to fully examine the blueberry fruit cultivated in Georgia. Shota Rustaveli National Science Foundation Grant FR/335/10-160/14, gave us an opportunity to continue our previous works and conduct research on several berries, among them of course the chemical composition of stored Blueberry. We were able to conduct the first study that included examining qualitative and quantitative features of bioactive compounds in Georgian Blueberry. This experiments were held in the ‘West Georgia Regional Chromatography center’ (Grant AP/96/13) of our university, that is equipped with modern equipment like HPLC UV-Vis, RI-detector, HPLC-conductivity detector, UPLC-MS-detector. Biochemical analysis was conducted using different physico-chemical and instrumental methods. Separation-identification and quantitative analysis were conducted using UPLC-MS (Waters Acquity QDa detector), HPLC (Waters Brceze 1525, UV-Vis 2489 detectors), pH-meters (Mettler Toledo). Refractrometer -Misco , Spectrometer –Cuvette Changer (Mettler Toledo UV5A), C18 Cartridge Solid Phase Extraction (SPE) Waters Sep-Pak C18 (500 mg), Chemicals – stability radical- 2,2-Diphenil-1-picrilhydrazyl (Aldrich-germany), Acetonitrile, Methanol, Acetic Acid (Merck-Germany), AlCl3, Folin Ciocalteu reagent (preparation), Standarts –Callic acid, Quercetin. Carbohydrate HPLC-RI analysis used systems acetonitrile-water (80-20). UPLC-MS analysis used systems- solvent A- Water +1 % acetic acid და solvent -B Methanol +1% acetic acid). It was concluded that the amount of sugars was in range of 5-9 %, mostly glucose and fructose. Also, the amount of organic acids was 0.2-1.2% most of which was malic and citric acid. Anthocians were also present in the sample 200-550mg/100g. We were able to identify up to 15 different compounds, most of which were products of delphinidine and cyanide. All species have high antioxidant level(DPPH). By rapidly freezing the sample and then keeping it in specific conditions allowed us to keep the sample for 12 months. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidants" title="antioxidants">antioxidants</a>, <a href="https://publications.waset.org/abstracts/search?q=bioactive" title=" bioactive"> bioactive</a>, <a href="https://publications.waset.org/abstracts/search?q=blueberry" title=" blueberry"> blueberry</a>, <a href="https://publications.waset.org/abstracts/search?q=storage" title=" storage"> storage</a> </p> <a href="https://publications.waset.org/abstracts/80347/variation-of-biologically-active-compounds-and-antioxidancy-in-the-process-of-blueberry-storage" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80347.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">212</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Evaluation Method for Fouling Risk Using Quartz Crystal Microbalance</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Natsuki%20Kishizawa">Natsuki Kishizawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Keiko%20Nakano"> Keiko Nakano</a>, <a href="https://publications.waset.org/abstracts/search?q=Hussam%20Organji"> Hussam Organji</a>, <a href="https://publications.waset.org/abstracts/search?q=Amer%20Shaiban"> Amer Shaiban</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Albeirutty"> Mohammad Albeirutty </a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the most important tasks in operating desalination plants using a reverse osmosis (RO) method is preventing RO membrane fouling caused by foulants found in seawater. Optimal design of the pre-treatment process of RO process for plants enables the reduction of foulants. Therefore, a quantitative evaluation of the fouling risk in pre-treated water, which is fed to RO, is required for optimal design. Some measurement methods for water quality such as silt density index (SDI) and total organic carbon (TOC) have been conservatively applied for evaluations. However, these methods have not been effective in some situations for evaluating the fouling risk of RO feed water. Furthermore, stable management of plants will be possible by alerts and appropriate control of the pre-treatment process by using the method if it can be applied to the inline monitoring system for the fouling risk of RO feed water. The purpose of this study is to develop a method to evaluate the fouling risk of RO feed water. We applied a quartz crystal microbalance (QCM) to measure the amount of foulants found in seawater using a sensor whose surface is coated with polyamide thin film, which is the main material of a RO membrane. The increase of the weight of the sensor after a certain length of time in which the sample water passes indicates the fouling risk of the sample directly. We classified the values as “FP: Fouling Potential”. The characteristics of the method are to measure the very small amount of substances in seawater in a short time: < 2h, and from a small volume of the sample water: < 50mL. Using some RO cell filtration units, a higher correlation between the pressure increase given by RO fouling and the FP from the method than SDI and TOC was confirmed in the laboratory-scale test. Then, to establish the correlation in the actual bench-scale RO membrane module, and to confirm the feasibility of the monitoring system as a control tool for the pre-treatment process, we have started a long-term test at an experimental desalination site by the Red Sea in Jeddah, Kingdom of Saudi Arabia. Implementing inline equipment for the method made it possible to measure FP intermittently (4 times per day) and automatically. Moreover, for two 3-month long operations, the RO operation pressure among feed water samples of different qualities was compared. The pressure increase through a RO membrane module was observed at a high FP RO unit in which feed water was treated by a cartridge filter only. On the other hand, the pressure increase was not observed at a low FP RO unit in which feed water was treated by an ultra-filter during the operation. Therefore, the correlation in an actual scale RO membrane was established in two runs of two types of feed water. The result suggested that the FP method enables the evaluation of the fouling risk of RO feed water. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fouling" title="fouling">fouling</a>, <a href="https://publications.waset.org/abstracts/search?q=monitoring" title=" monitoring"> monitoring</a>, <a href="https://publications.waset.org/abstracts/search?q=QCM" title=" QCM"> QCM</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20quality" title=" water quality"> water quality</a> </p> <a href="https://publications.waset.org/abstracts/45000/evaluation-method-for-fouling-risk-using-quartz-crystal-microbalance" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45000.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">212</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Long-Term Exposure Assessments for Cooking Workers Exposed to Polycyclic Aromatic Hydrocarbons and Aldehydes Containing in Cooking Fumes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chun-Yu%20Chen">Chun-Yu Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Kua-Rong%20Wu"> Kua-Rong Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Cheng%20Chen"> Yu-Cheng Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Perng-Jy%20Tsai"> Perng-Jy Tsai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cooking fumes are known containing polycyclic aromatic hydrocarbons (PAHs) and aldehydes, and some of them have been proven carcinogenic or possibly carcinogenic to humans. Considering their chronic health effects, long-term exposure data is required for assessing cooking workers’ lifetime health risks. Previous exposure assessment studies, due to both time and cost constraints, mostly were based on the cross-sectional data. Therefore, establishing a long-term exposure data has become an important issue for conducting health risk assessment for cooking workers. An approach was proposed in this study. Here, the generation rates of both PAHs and aldehydes from a cooking process were determined by placing a sampling train exactly under the under the exhaust fan under the both the total enclosure condition and normal operating condition, respectively. Subtracting the concentration collected by the former (representing the total emitted concentration) from that of the latter (representing the hood collected concentration), the fugitive emitted concentration was determined. The above data was further converted to determine the generation rates based on the flow rates specified for the exhaust fan. The determinations of the above generation rates were conducted in a testing chamber with a selected cooking process (deep-frying chicken nuggets under 3 L peanut oil at 200°C). The sampling train installed under the exhaust fan consisted respectively an IOM inhalable sampler with a glass fiber filter for collecting particle-phase PAHs, followed by a XAD-2 tube for gas-phase PAHs. The above was also used to sample aldehydes, however, installed with a filter pre-coated with DNPH, and followed by a 2,4-DNPH-cartridge for collecting particle-phase and gas-phase aldehydes, respectively. PAHs and aldehydes samples were analyzed by GC/MS-MS (Agilent 7890B), and HPLC-UV (HITACHI L-7100), respectively. The obtained generation rates of both PAHs and aldehydes were applied to the near-field/ far-field exposure model to estimate the exposures of cooks (the estimated near-field concentration), and helpers (the estimated far-field concentration). For validating purposes, both PAHs and aldehydes samplings were conducted simultaneously using the same sampling train at both near-field and far-field sites of the testing chamber. The sampling results, together with the use of the mixed-effect model, were used to calibrate the estimated near-field/ far-field exposures. In the present study, the obtained emission rates were further converted to emission factor of both PAHs and aldehydes according to the amount of food oil consumed. Applying the long-term food oil consumption records, the emission rates for both PAHs and aldehydes were determined, and the long-term exposure databanks for cooks (the estimated near-field concentration), and helpers (the estimated far-field concentration) were then determined. Results show that the proposed approach was adequate to determine the generation rates of both PAHs and aldehydes under various fan exhaust flow rate conditions. The estimated near-field/ far-field exposures, though were significantly different from that obtained from the field, can be calibrated using the mixed effect model. Finally, the established long-term data bank could provide a useful basis for conducting long-term exposure assessments for cooking workers exposed to PAHs and aldehydes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aldehydes" title="aldehydes">aldehydes</a>, <a href="https://publications.waset.org/abstracts/search?q=cooking%20oil%20fumes" title=" cooking oil fumes"> cooking oil fumes</a>, <a href="https://publications.waset.org/abstracts/search?q=long-term%20exposure%20assessment" title=" long-term exposure assessment"> long-term exposure assessment</a>, <a href="https://publications.waset.org/abstracts/search?q=modeling" title=" modeling"> modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=polycyclic%20aromatic%20hydrocarbons%20%28PAHs%29" title=" polycyclic aromatic hydrocarbons (PAHs)"> polycyclic aromatic hydrocarbons (PAHs)</a> </p> <a href="https://publications.waset.org/abstracts/81303/long-term-exposure-assessments-for-cooking-workers-exposed-to-polycyclic-aromatic-hydrocarbons-and-aldehydes-containing-in-cooking-fumes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81303.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Optical Imaging Based Detection of Solder Paste in Printed Circuit Board Jet-Printing Inspection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20Heinemann">D. Heinemann</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Schramm"> S. Schramm</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Knabner"> S. Knabner</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Baumgarten"> D. Baumgarten</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: Applying solder paste to printed circuit boards (PCB) with stencils has been the method of choice over the past years. A new method uses a jet printer to deposit tiny droplets of solder paste through an ejector mechanism onto the board. This allows for more flexible PCB layouts with smaller components. Due to the viscosity of the solder paste, air blisters can be trapped in the cartridge. This can lead to missing solder joints or deviations in the applied solder volume. Therefore, a built-in and real-time inspection of the printing process is needed to minimize uncertainties and increase the efficiency of the process by immediate correction. The objective of the current study is the design of an optimal imaging system and the development of an automatic algorithm for the detection of applied solder joints from optical from the captured images. Methods: In a first approach, a camera module connected to a microcomputer and LED strips are employed to capture images of the printed circuit board under four different illuminations (white, red, green and blue). Subsequently, an improved system including a ring light, an objective lens, and a monochromatic camera was set up to acquire higher quality images. The obtained images can be divided into three main components: the PCB itself (i.e., the background), the reflections induced by unsoldered positions or screw holes and the solder joints. Non-uniform illumination is corrected by estimating the background using a morphological opening and subtraction from the input image. Image sharpening is applied in order to prevent error pixels in the subsequent segmentation. The intensity thresholds which divide the main components are obtained from the multimodal histogram using three probability density functions. Determining the intersections delivers proper thresholds for the segmentation. Remaining edge gradients produces small error areas which are removed by another morphological opening. For quantitative analysis of the segmentation results, the dice coefficient is used. Results: The obtained PCB images show a significant gradient in all RGB channels, resulting from ambient light. Using different lightings and color channels 12 images of a single PCB are available. A visual inspection and the investigation of 27 specific points show the best differentiation between those points using a red lighting and a green color channel. Estimating two thresholds from analyzing the multimodal histogram of the corrected images and using them for segmentation precisely extracts the solder joints. The comparison of the results to manually segmented images yield high sensitivity and specificity values. Analyzing the overall result delivers a Dice coefficient of 0.89 which varies for single object segmentations between 0.96 for a good segmented solder joints and 0.25 for single negative outliers. Conclusion: Our results demonstrate that the presented optical imaging system and the developed algorithm can robustly detect solder joints on printed circuit boards. Future work will comprise a modified lighting system which allows for more precise segmentation results using structure analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=printed%20circuit%20board%20jet-printing" title="printed circuit board jet-printing">printed circuit board jet-printing</a>, <a href="https://publications.waset.org/abstracts/search?q=inspection" title=" inspection"> inspection</a>, <a href="https://publications.waset.org/abstracts/search?q=segmentation" title=" segmentation"> segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=solder%20paste%20detection" title=" solder paste detection"> solder paste detection</a> </p> <a href="https://publications.waset.org/abstracts/29447/optical-imaging-based-detection-of-solder-paste-in-printed-circuit-board-jet-printing-inspection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29447.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">336</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">&copy; 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