Manufacturing | NorthStar Medical Radioisotopes, LLC

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data-image-src="https://www.northstarnm.com/wp-content/uploads/2021/06/bg-supply.jpg" data-natural-width="1432" data-natural-height="1786"></div> <div class="section-content "> <section class="h2_header_short"> <div class="container"> <div class="header-inner"> <a href="https://www.northstarnm.com/development/" class="h2_breadcrumb_link mb-2 dk-blue">Development</a> <h1 class="mb-5">NorthStar's<br><span>Manufacturing</span></h1> <div class="h2_intro_box"> <p>We routinely produce Copper-67 (Cu-67) to ensure expanded and reliable supply of this promising radioisotope for the treatment of patients with cancer. Explore what lies ahead for radioisotope manufacturing in Beloit, Wisconsin.</p> </div> </div> </div> </section> <section class="r7_row_multicolumns py-0 " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="p-5 bg-gray-fade mb-5"> <div class="row py-short align-items-center "> <div class="col-md-4 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2021/08/NorthStar_08242020_0030.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <h4 class="bright-green">ISOTOPE PROCESSING FACILITY</h4> <p>Our Isotope Processing facility features a chemical processing line, analytical testing and metallurgy laboratories, as well as radioactive storage. Regular production runs of radiochemical grade (RCG) Copper-67 (Cu-67) occur in this facility. Currently, the building is undergoing a significant infrastructure project, which includes the addition of new processing lines and product hot cells. Additionally, work is underway to retrofit previously installed hot cells that were dedicated to the production of other isotopes but will now be used to help us maximize our output of Cu-67. These upgrades are part of our plan to upscale processes and position ourselves for large-scale cGMP commercial production. Furthermore, this facility houses a cGMP-compliant, final dose product CDMO suite.</p> </div>  </div> </div> <div class="row py-short align-items-center "> <div class="col-md-4 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2024/02/Be3-Man-22Feb2024-01.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <h4 class="bright-green">COPPER-67 ACCELERATOR PRODUCTION FACILITY</h4> <p>We are currently irradiating and investing in the expansion of our groundbreaking technology to produce Copper-67 (Cu-67) from Zinc-68 (Zn-68) using electron beam accelerators. During the initial construction phase, our team had the foresight to prepare the areas immediately adjacent to the production facility, allowing for easier expansion. NorthStar’s unique and proprietary electron accelerator production facility and processes are designed to optimize efficiency throughout the production cycle, providing us with the flexibility to produce batches of various sizes based on market demand.</p> </div>  </div> </div> <div class="row py-short align-items-center "> <div class="col-md-4 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/11/Man-Be4-01.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <div id="manufacturing"></div> <h4 class="bright-green">ACTINIUM-225 PRODUCTION FACILITY</h4> <p>We continue our investment in groundbreaking technology to produce non-carrier added Actinium-225 (n.c.a. Ac-225) from Radium-226 (Ra-226) using our electron beam accelerators. There are several technologies used to produce Ac-225 but none that can independently scale to meet commercial quantities. NorthStar’s method is capable of meeting customer demand. Our stand-alone facility, currently under construction, will fully house our dedicated electron beam accelerator, chemical processing line and all analytical laboratory capabilities.</p> </div>  </div> </div> <div class="row py-short align-items-center "> <div class="col-md-4 text-center"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/05/circle-cdmo-facility.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <div id="cdmo"></div> <h4 class="bright-green">CDMO/CMO FACILITY</h4> <p>NorthStar’s Radiopharmaceutical CDMO/CMO unit offers customized services and expertise to accelerate biopharmaceutical companies’ development and commercialization programs. The NorthStar CDMO is the first and only U.S. facility providing commercial-scale, multi-radioisotope production and radiopharmaceutical development all on the same campus. With a 52,000 sq. ft. footprint, it sets new industry standards, serving the growing therapeutic and diagnostic radiopharmaceuticals market. Our facility effectively supports the entire product lifecycle, cGMP manufacturing suites, one EU compliant manufacturing suite and radiation safety programs to ensure high-quality and safe practices.</p> </div>  </div> </div> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg " > <div class="parallax-container section-parallax" data-parallax="scroll" data-position="top" data-bleed="10" data-image-src="https://www.northstarnm.com/wp-content/uploads/2021/05/bg-blue-balls.jpg" data-natural-width="2020" data-natural-height="1410"></div> <div class="section-content "> <section class="r7_row_multicolumns py-tall-t " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="p-5 bg-white-fade mb-5"> <div class="row py-short align-items-center "> <div class="col-md-4 "> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2024/03/small-electrons-01.png" class=" w-100 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-8 "> <h2 class="title mb-4 lt-blue"> BIG Innovation<br><span>Small ELECTRONS</span> </h2> <div class="copy mb-4 mb-md-0"> <p>Since 2023, NorthStar has been utilizing groundbreaking technology to produce Copper-67 (Cu-67) and Actinium-225 (Ac-225) using dual Rhodotron® TT300-HE (High Energy) electron-beam accelerators.</p> <p>NorthStar’s unique electron accelerator-based production method for copper-67 starts with the irradiation of zinc-68, a readily available transition metal. This irradiation method uses accelerated electrons to create photons which knock off a proton from zinc-68, leading to the production of high purity copper-67 in commercial quantities. Any zinc-68 target material not irradiated can be recovered, reprocessed and reused in future copper-67 production cycles. As NorthStar’s environmentally preferred electron accelerator-based program is powered by electricity, there are no long-lasting radioactive waste products introduced to the environment during the production process.</p> <p>Similarly, NorthStar is creating the first-in-kind electron accelerator-based program for the commercial-scale production of Ac-225. This unique method will irradiate radium-226 with produced photons, which causes a neutron to be knocked off, leading to radium-225, which is then used as a source for non-carrier added Ac-225. The radium-225 sources are stored in a source farm with each source generating various quantities of non-carrier added Ac-225. After a period of source decay, radium can then be removed and reprocessed to recover radium-226, then re-irradiated and reused.</p> </div>  </div> </div> <div class="row py-short align-items-center flex-md-row-reverse"> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <p><video class="bg-video" poster="https://www.northstarnm.com/wp-content/uploads/2024/03/accelertator-cavity.jpg" autoplay="autoplay" loop="loop" muted="" width="300" height="150"><source src="https://www.northstarnm.com/wp-content/uploads/2024/03/accelertator-cavity.webm" class="bg-video" type="video/mp4" controls="controls" src="" /></video></p> </div>  </div> <div class="col-md-6 "> <h2 class="title mb-4 lt-blue"> HOW IT WORKS </h2> <div class="copy mb-4 mb-md-0"> <p>A filament in the cathode gets red hot, and electrons boil off and enter the accelerator cavity. The electrons travel across the cavity, and then get turned around by electromagnets in order to pass through the cavity again. Each time the electron makes a pass, it picks up energy. Each electron goes back and forth across the cavity in a daisy-chain pattern, and after 12 passes, the electrons emerge traveling at nearly the speed of light. At 40 million electron volts of energy, this is 300,000 times more energy than an electron has in your house wiring.</p> </div>  </div> </div> </div> </div> </div> </div> </section> <section class="r7_row_multicolumns py-tall-b " > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="p-5 bg-bright-blue white"> <div class="row align-items-start "> <div class="col-md-4 text-center mb-5 mb-md-0"> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/11/Man-Green-Future-01.png" class=" w-75 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-8 "> <div class="pre-title mb-3 bright-green"> OUR ADVANCED ELECTRON BEAM<br>ACCELERATORS ARE MAJOR<br>INVESTMENTS INTO A </div> <h2 class="title mb-4 "> GREEN<br><span>FUTURE</span> </h2> <div class="copy mb-4 mb-md-0"> <p>NorthStar is utilizing environmentally preferred production technology for its high purity n.c.a. Ac-225 and Cu-67. Electron accelerators will produce these radioisotopes, which are free of long-lived radioactive contaminants and byproducts associated with many other production methods, which pose regulatory and waste management challenges for hospitals and health systems.</p> </div>  </div> </div> </div> </div> </div> </div> </section> </div> </section> <section class="section-bg bg-dk-blue" > <div class="section-content "> <section class="r7_row_multicolumns footer-cta" > <div class="container"> <div class="row"> <div class="col-12 relative d-flex flex-column "> <div class="row py-short align-items-center "> <div class="col-md-4 "> <h2 class="title mb-4 "> REDUCE<br>RECOVER<BR><span>REUSE</span> </h2>  </div> <div class="col-md-2 "> <div class="featured-img"> <img src="https://www.northstarnm.com/wp-content/uploads/2023/11/RRR-CIR-01.png" class="max-width-mobile w-100 img-fluid mb-5 mb-lg-0" alt="" /> </div> </div> <div class="col-md-6 "> <div class="copy mb-4 mb-md-0"> <p>All NorthStar processes are non-uranium based and employ the Company’s “Reduce, Recover, Reuse” approach for reliable, domestic and environmentally sound medical radioisotope production.</p> </div>  </div> </div> </div> </div> </div> </section> </div> </section> </div> <footer class="py-5"> <div class="container"> <div class="row"> <div class="col-12 col-md-4 mb-4 mb-md-0 py-md-2"> <p class="footer-brand"><img src="https://www.northstarnm.com/wp-content/themes/northstar/img/logo-w.svg" alt="NorthStar Medical Radioisotopes, LLC" class="w-100 img-fluid" /></p> <div class="contact-box"> <p>1800 Gateway Boulevard<br /> Beloit, WI 53511<br /> <strong>Phone:</strong> <a href="tel:8444386659">(844) 438-6659</a><br /> <strong>Phone:</strong> <a href="tel:6083138000">(608) 313-8000</a></p> </div> </div> <div class="col-md-4 py-md-2 mb-4 mb-md-0"> <div class="menu-main-menu-container"><ul id="menu-main-menu-2" class="menu" itemscope itemtype="http://www.schema.org/SiteNavigationElement"><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-12125"><a href="https://www.northstarnm.com/radiopharmaceutical-therapy/">Radiopharmaceutical Therapy</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-12604"><a href="https://www.northstarnm.com/cdmo-cmo/">CDMO/CMO</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page current-page-ancestor current-menu-ancestor current-menu-parent current-page-parent current_page_parent current_page_ancestor menu-item-10982"><a href="https://www.northstarnm.com/development/">Development</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10981"><a href="https://www.northstarnm.com/company/">Company</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-10980"><a href="https://www.northstarnm.com/careers/">Careers</a></li> <li class="searchlink menu-item menu-item-type-custom menu-item-object-custom menu-item-10984"><a href="#search"><i class="fas fa-search"></i> <span class="navhide">Search</span></a></li> </ul></div> </div> <div class="col-12 col-md-4 mb-4 mb-md-0 border-left px-md-4 py-md-2"> <div class="f-col-title"> HOW CAN WE HELP? </div> <div class="f-col-content"> <p>Questions about our company, products, supply solutions, careers or anything else?</p> </div> <div class="f-col-link"> <a href="https://www.northstarnm.com/company/contact-us/" target="" class="btn btn-wire">Contact Us</a> </div> <div class="inline-links"> <ul class="social-links"> <li><a href="https://www.linkedin.com/company/northstar-medical-radioisotopes-llc/" target="_blank" title=""><span class="social-text">LinkedIn</span><span class="fa-stack" style="vertical-align: top;"> <i class="fas fa-circle fa-stack-2x"></i> <i class="fab fa-linkedin-in fa-stack-1x fa-inverse"></i> </span></a></li> <li><a href="https://www.instagram.com/northstarmedicalradioisotopes/" target="_blank" title=""><span class="social-text">Instagram</span><span class="fa-stack" style="vertical-align: top;"> <i class="fas fa-circle fa-stack-2x"></i> <i class="fab fa-instagram fa-stack-1x fa-inverse"></i> </span></a></li> </ul> </div> </div> <div class="col-12 footer-copyright py-3 mb-5 white"> ©<script>var CurrentYear = new Date().getFullYear(); document.write(CurrentYear);</script> NMR. 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