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(!window.AdButler){(function(){var s = document.createElement("script"); s.async = true; s.type = "text/javascript";s.src = 'https://servedbyadbutler.com/app.js';var n = document.getElementsByTagName("script")[0]; n.parentNode.insertBefore(s, n);}());}</script> <script> var myRand = Math.floor( Math.random() * 1000 ); var AdButler = AdButler || {}; AdButler.ads = AdButler.ads || []; var abkw = window.abkw || ''; var plc334038 = window.plc334038 || 0; //document.write('<'+'div id="placement_334038_'+plc334038+'"></'+'div>'); //no documentwrite var node = document.createElement('div'); node.id = 'placement_334038_'+ plc334038; document.getElementById( 'adBoxlg_2C917033-CD0C-03CF-6156636383257D11' ).id = "adBoxlg_2C917033-CD0C-03CF-6156636383257D11_" + myRand; document.getElementById( 'adBoxlg_2C917033-CD0C-03CF-6156636383257D11_' + myRand ).appendChild(node); AdButler.ads.push({ handler: function(opt){ AdButler.register(165731, 334038, [728,90], 'placement_334038_'+opt.place, opt); } , 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class="container"><!-- Heading 2 --> <h2><em>SLAS Discovery</em>: Advancing the Science of Drug Discovery</h2> <!-- Body Copy with Text Formatting --> <div class="row"> <div class="col-md-8"> <p><em>SLAS Discovery</em> reports how scientists develop and use novel technologies and/or approaches to provide and characterize chemical and biological tools to understand and treat human disease. The journal focuses on drug discovery sciences with a strong record of scientific rigor and impact, reporting on research that:</p> <ul> <li>Enables and improves target validation</li> <li>Evaluates current drug discovery technologies</li> <li>Provides novel research tools</li> <li>Incorporates research approaches that enhance depth of knowledge and drug discovery success</li> </ul> <p><strong><em>SLAS Discovery’s</em> Editorial Scope includes:</strong> scientific and technical advances in target identification/validation (including chemical probes, RNA silencing, gene editing technologies); biomarker discovery; assay development; virtual, medium- or high-throughput screening (biochemical and biological, biophysical, phenotypic, toxicological, ADME); lead generation/ optimization; chemical biology; informatics (data analysis, image analysis, statistics, bio- and chemo-informatics); review articles on target biology, new paradigms in drug discovery and advances in drug discovery technologies</p> <p><strong>Publishes:</strong> annually in January, March, April, June, July, September, October and December</p> <div class="button"><a class="btn btn-primary" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.editorialmanager.com/slasdisc/default.aspx" target="_blank">SUBMIT MANUSCRIPT <em>SLAS DISCOVERY</em></a> <a class="btn btn-primary" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://slas-discovery.org/" target="_blank">READ <em>SLAS DISCOVERY</em></a></div> <h3>Advertising in Peer-Reviewed, Open Access Scientific Journals</h3> <p>The SLAS journals – <a data-feathr-click-track="true" data-feathr-link-aids="["5e835b38bbf24c15969ff8c8"],5e835b38bbf24c15969ff8c8" href="https://www.slas.org/publications/slas-technology/"><em>SLAS Technology</em></a><em> </em>and <a data-feathr-click-track="true" data-feathr-link-aids="["5e835b38bbf24c15969ff8c8"],5e835b38bbf24c15969ff8c8" href="https://www.slas.org/publications/slas-discovery/"><em>SLAS Discovery</em></a> – are now published Gold Open Access by Elsevier. Online advertising information is available from <a data-feathr-click-track="true" data-feathr-link-aids="["5e835b38bbf24c15969ff8c8"],5e835b38bbf24c15969ff8c8" href="mailto:k.partridge@elsevier.com">Kevin Partridge</a> via email or call +44 (0)1865 843717.</p> <p><a class="btn btn-primary" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="/SLAS/assets/File/public/publications/SLAS%20Journals%20San%20Diego%202025%20collections.pdf" target="_blank">Sponsorship opportunities</a></p> </div> <div class="col-md-4"> <nav class="blackbox-menu" role="navigation"><!-- Heading --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="">Useful Links </a></h3> <!-- Links --> <ul class="collapse in panel-collapse" role="tabpanel"> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="/publications/journal-open-access-faq/">Journal Open Access FAQ</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas.org/publications/slas-journals-manuscript-category-descriptions-and-examples/">Article Types</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="/publications/call-for-papers/#Discovery">Call for Papers</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.editorialmanager.com/slasdisc/default.aspx" target="_blank">Submit a Manuscript</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="/publications/slas-special-issues-and-collections">Special Issues & Collections</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="/publications/journal-author-guidelines/">Journal Author Guidelines</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="/publications/author-promotional-tools/">Author Promotional Tools</a></li> <li><a href="https://www.slas.org/publications/author-reviewer-resources-guidelines/">Reviewer Resources and Guidelines</a></li> <li><a href="https://www.slas.org/publications/the-peer-review-process/">The Peer Review Process</a></li> <li><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(23)00004-7/fulltext" target="_blank"><em>SLAS Discovery</em> Top Ten</a></li> <!---<li><a data-feathr-click-track="true" href="/publications/slas-discovery/slas-celebrates-the-top-10-most-cited-slas-discovery-articles/">Top Ten Cited Articles</a></li>---></ul> </nav> </div> </div> </div> </section> <section class="featured-articles article-listing-dark"> <div class="container"><!-- Heading --> <h2>Latest Articles</h2> <!-- Article Listing --> <div class="article-listing row"><!-- Article --> <div class="article col-sm-4 discovery"><!-- Graphics --> <div class="graphics"><!-- Image --> <div class="image" style="background-image:url('/SLAS/assets/image/featured_content/home-featured-articles-1.jpg')"> </div> <!-- Category --> <p class="category"><em>SLAS Discovery</em></p> </div> <!-- Article Title --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(24)00018-2/fulltext" target="_blank">POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening</a></h3> <!-- Details --> <div class="details"><!-- Date --> <p class="date">April 2024</p> <!-- Byline --> <p class="byline">By Alice Lanne, Catherine Bardelle, Gareth Davies, Antonia Turberville, Hannah Semple, Rachel Moore, Geoffrey A. Holdgate</p> </div> <!-- Read More --><a class="read-more" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(24)00018-2/fulltext" target="_blank">Read More</a></div> <!-- SLAS Technology Article --> <div class="article col-sm-4 discovery"><!-- Graphics --> <div class="graphics"><!-- Image --> <div class="image" style="background-image:url('/SLAS/assets/image/featured_content/home-featured-articles-2.jpg')"> </div> <!-- Category --> <p class="category"><em>SLAS Discovery</em></p> </div> <!-- Article Title --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(24)00020-0/fulltext" target="_blank">Enhancing scaffold-free spheroid models: 3D cell bioprinting method for metastatic HSC3–Oral squamous carcinoma cell line</a></h3> <!-- Details --> <div class="details"><!-- Date --> <p class="date">April 2024</p> <!-- Byline --> <p class="byline">By Taís Bacelar Sacramento de Araújo, Raphael Luís Rocha Nogueira, Leonardo de Oliveira Siquara da Rocha, Iasmin Nogueira Bastos, Rosane Borges Dias, Bruno Solano De Freitas Souza, Daniel William Lambert, Ricardo D. Coletta, Viviane Aline Oliveira Silva, Clarissa A. Gurgel Rocha</p> </div> <!-- Read More --><a class="read-more" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(24)00020-0/fulltext" target="_blank">Read More</a></div> <!-- SLAS Discovery Article --> <div class="article col-sm-4 discovery"><!-- Graphics --> <div class="graphics"><!-- Image --> <div class="image" style="background-image:url('/SLAS/assets/image/featured_content/home-featured-articles-3.jpg')"> </div> <!-- Category --> <p class="category"><em>SLAS Discovery</em></p> </div> <!-- Article Title --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(24)00017-0/fulltext" target="_blank">Outline and background for the EU-OS solubility prediction challenge</a></h3> <!-- Details --> <div class="details"><!-- Date --> <p class="date">March 2024</p> <!-- Byline --> <p class="byline">By Wenyu Wang, Jing Tang, Andrea Zaliani</p> </div> <!-- Read More --><a class="read-more" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://www.slas-discovery.org/article/S2472-5552(24)00017-0/fulltext" target="_blank">Read More</a></div> </div> </div> </section> <!-- Recent Articles --> <section class="recent-articles"> <div class="container"><!-- Heading --> <h2>Most Read Articles</h2> <!-- Article Listing --> <div class="article-listing row"><!-- Article --> <div class="article col-sm-4 discovery"><!-- Graphics --> <div class="graphics"><!-- Image --> <div class="image" style="background-image:url('/SLAS/assets/image/featured_content/home-featured-articles-1.jpg')"> </div> <!-- Category --> <p class="category"><em>SLAS Discovery</em></p> </div> <!-- Article Title --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://slas-discovery.org/article/S2472-5552(24)00004-2/fulltext" target="_blank">Covalent Hits and Where to Find Them</a></h3> <!-- Details --> <div class="details"><!-- Date --> <p class="date">January 2024</p> <!-- Byline --> <p class="byline">By Simon C. C. Lucas, J. Henry Blackwell, Sarah H. Hewitt, Hannah Semple, Benjamin C. Whitehurst, Hua Xu</p> </div> <!-- Read More --><a class="read-more" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://slas-discovery.org/article/S2472-5552(24)00004-2/fulltext" target="_blank">Read More</a></div> <!-- Article --> <div class="article col-sm-4 discovery"><!-- Graphics --> <div class="graphics"><!-- Image --> <div class="image" style="background-image:url('/SLAS/assets/image/featured_content/home-featured-articles-1.jpg')"> </div> <!-- Category --> <p class="category"><em>SLAS Discovery</em></p> </div> <!-- Article Title --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://slas-discovery.org/article/S2472-5552(23)00098-9/fulltext" target="_blank">Screening for Molecular Glues – Challenges and Opportunities</a></h3> <!-- Details --> <div class="details"><!-- Date --> <p class="date">December 2023</p> <!-- Byline --> <p class="byline">By Geoffrey A. Holdgate, Catherine Bardelle, Sophia K. Berry, Alice Lanne, Maria Emanuela Cuomo</p> </div> <!-- Read More --><a class="read-more" data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://slas-discovery.org/article/S2472-5552(23)00098-9/fulltext" target="_blank">Read More</a></div> <!-- SLAS Technology Article --> <div class="article col-sm-4 discovery"><!-- Graphics --> <div class="graphics"><!-- Image --> <div class="image" style="background-image:url('/SLAS/assets/image/featured_content/home-featured-articles-1.jpg')"> </div> <!-- Category --> <p class="category"><em>SLAS Discovery</em></p> </div> <!-- Article Title --> <h3><a data-feathr-click-track="true" data-feathr-link-aids="5e835b38bbf24c15969ff8c8" href="https://slas-discovery.org/article/S2472-5552(24)00006-6/fulltext" target="_blank">The Openochem Consensus Model is the Best-Performing Open-Source Predictive Model in the First EUOS/SLAS Joint Compound Solubility Challenge</a></h3> <!-- Details --> <div class="details"><!-- Date --> <p class="date">February 2024</p> <!-- Byline --> <p class="byline">By Andrea Hunklinger, Peter Hartog, Martin Sicho, Guillaume, Igor V. 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