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KEGG PATHWAY: Cholinergic synapse - Homo sapiens (human)
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} function open_object_list (mapno, org) { org = org || 'map' const url = `/kegg-bin/module_ko_list?map=${mapno}&org=${org}` const name = `${env.mapno}_object_list` window .open(url, name, 'popup=yes,width=700,height=400') .focus(); } //--> </script> </head> <body> <!-- header logo start --> <h1 class="page-title"> <a href="/kegg/pathway.html"><img alt="KEGG" border="0" src="/Fig/bget/kegg3.gif" /></a> Cholinergic synapse - Homo sapiens (human) </h1> <!-- header logo end --> <!-- page navigation start --> <div class="nav"> [ <a href="/brite/query=04725&htext=br08901.keg&option=-a&node_proc=br08901_org&proc_enabled=hsa&panel=collapse" id="navPathwayMenu">Pathway menu</a> | <a id="navOrganismGroup" href="/kegg-bin/organism_stat?mapno=04725">Organism group</a> | <a href="/entry/hsa04725" id="navPathwayEntry">Pathway entry</a> | <a id="descLink" href="#description">Show description</a> | <a id="downloadMenu" href="#">Download</a> | <a href="javascript:void(window.open('/kegg/document/help_pathway.html','KEGG_Help','width=720,height=640'))">Help</a> ] <div id="description" class="hidden"> Acetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as learning, memory, attention and motor control. When released in the synaptic cleft, ACh binds to two distinct types of receptors: Ionotropic nicotinic acetylcholine receptors (nAChR) and metabotropic muscarinic acetylcholine receptors (mAChRs). The activation of nAChR by ACh leads to the rapid influx of Na+ and Ca2+ and subsequent cellular depolarization. Activation of mAChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1-M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium. In the cleft, ACh may also be hydrolyzed by acetylcholinesterase (AChE) into choline and acetate. The choline derived from ACh hydrolysis is recovered by a presynaptic high-affinity choline transporter (CHT). </div> <!-- organism list start --> <form name="selmenu" method="get"> <input type="button" id="changePathwayTypeButton" value="Change pathway type"> <input type="text" class="hidden" name="mapno" value="04725" /> <input type="text" class="hidden" id="scale" name="scale" value="1" /> <input type="text" class="hidden" id="displayNoColoringImage" name="nocolor" value="0" /> <input type="text" class="hidden" id="displayDescription" name="show_description" value="hide" /> <input type="text" class="hidden" id="displayControlPanel" name="show_module_list" value="show" /> <input type="text" class="hidden" id="clickableMode" name="clickable_mode" value="" /> <input type="text" class="hidden" name="module" value="" /> </form> <!-- organism list end --> </div> <!-- page navigation end --> <!-- pathway image start --> <div class="image-block" style="position:static;"> <img 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title="110117499 (P3R3URF-PIK3R3), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3)" /> <area id="9E16CE7A" shape="rect" coords="973,737,1019,754" class="original" href="/entry/hsa:10000+hsa:207+hsa:208" title="10000 (AKT3), 207 (AKT1), 208 (AKT2)" /> <area id="FDED54D8" shape="rect" coords="1048,737,1094,754" class="original" href="/entry/hsa:596" title="596 (BCL2)" /> <area id="AE983A2E" shape="rect" coords="759,744,805,761" class="original" href="/entry/hsa:775+hsa:776+hsa:778+hsa:779" title="775 (CACNA1C), 776 (CACNA1D), 778 (CACNA1F), 779 (CACNA1S)" /> <area id="139CD00B" shape="rect" coords="675,148,721,165" class="original" href="/entry/hsa:1139+hsa:89832" title="1139 (CHRNA7), 89832 (CHRFAM7A)" /> <area id="96B86442" shape="rect" coords="734,148,780,165" class="original" href="/entry/hsa:1128+hsa:1131+hsa:1133" title="1128 (CHRM1), 1131 (CHRM3), 1133 (CHRM5)" /> <area id="F5CA389C" shape="rect" coords="953,556,999,573" class="original" href="/entry/hsa:146850+hsa:23533+hsa:5294" title="146850 (PIK3R6), 23533 (PIK3R5), 5294 (PIK3CG)" /> <area id="FAE76B5B" shape="rect" coords="1028,556,1074,573" class="original" href="/entry/hsa:3265+hsa:3845+hsa:4893" title="3265 (HRAS), 3845 (KRAS), 4893 (NRAS)" /> <area id="FFE97AEA" shape="rect" coords="1097,556,1143,573" class="original" href="/entry/hsa:5604" title="5604 (MAP2K1)" /> <area id="07443E42" shape="rect" coords="1170,556,1216,573" class="original" href="/entry/hsa:5594+hsa:5595" title="5594 (MAPK1), 5595 (MAPK3)" /> <area id="09D35A2B" shape="rect" coords="1243,556,1289,573" class="original" href="/entry/hsa:2353" title="2353 (FOS)" /> <area id="5CB9B449" shape="rect" coords="831,710,877,727" class="original" href="/entry/hsa:3717" title="3717 (JAK2)" /> <area id="F1A4A883" shape="rect" coords="886,701,932,718" class="original" href="/entry/hsa:2534" title="2534 (FYN)" /> <area id="2993433F" shape="rect" coords="759,509,805,526" class="original" href="/entry/hsa:3760+hsa:3763" title="3760 (KCNJ3), 3763 (KCNJ6)" /> <area id="37B2B0F1" shape="rect" coords="41,46,240,71" class="original" href="/pathway/hsa04975" title="hsa04975: Fat digestion and absorption" data-entry="hsa04975" /> <area id="C48E92EF" shape="rect" coords="292,610,415,644" class="original" href="/pathway/hsa00564" title="hsa00564: Glycerophospholipid metabolism" data-entry="hsa00564" /> <area id="9C93665C" shape="rect" coords="401,473,524,507" class="original" href="/pathway/hsa04721" title="hsa04721: Synaptic vesicle cycle" data-entry="hsa04721" /> <area id="95B635E5" shape="rect" coords="895,324,1018,358" class="original" href="/pathway/hsa04020" title="hsa04020: Calcium signaling pathway" data-entry="hsa04020" /> <area id="07466019" shape="rect" coords="1134,507,1244,541" class="original" href="/pathway/hsa04010" title="hsa04010: MAPK signaling pathway" data-entry="hsa04010" /> </map> <map id="module_mapdata" name="module_mapdata" data-scale="1"> </map> </div> <!-- pathway image end --> <!-- control panel start --> <div id="controlPanel"> <div class="controller"> <div class="feature option"> <h5>Option</h5> <div> <div class="row scale"> <span class="title">Scale:</span> <span class="content"> <input class="simple-range" type="range" min="0.1" max="1" step="0.05" value="1"> <span class="label">100%</span> </span> </div> <div class="row image-resolution hidden"> <span class="title">Image resolution:</span> <span class="content"> <label> <input type="checkbox" value="high"> High </label> </span> </div> </div> </div> <div class="feature bgcolor hidden"> <h5>Background color</h5> <div> <div class="row color organism"> <div style="font-size:0.9em; margin-top:5px;">Organism</div> <div style="margin-top:5px;"> <input class="query org" type="text" value="hsa"> <input class="query dynamicaly" type="checkbox" value="1" ><br> <input class="query bgcolor" type="text" value=""><br> <input class="query kos" type="text" value=""> </div> <div style="margin-top:5px;" class="options"> <label> <input class="split-cell" type="checkbox" > Split cells that has orgs. </label><br> <label> <input class="exclude-white-cell" type="checkbox" > Exclude cells that has no orgs. </label><br> </div> </div> </div> </div> <div class="feature search"> <h5>Search</h5> <div> <div class="row query"> <form> <input type="text" name="query" style="width:130px;" autocomplete="off" value=""> <input type="submit" value="Go"> <span class="ui-icon button ui-icon-close clear-query hidden"></span> </form> </div> <div class="row result"> </div> </div> </div> <div class="feature search-pathway"> <h5>ID search <span class="ui-icon ui-icon-plus"></span> </h5> <div> <form> <div class="row" style="display:grid; grid-template-columns:135px 1fr; column-gap:5px;"> <div> <textarea class="query" rows="2" style="width:130px; resize:none;"></textarea> </div> <div> <input type="submit" class="submit" value="Go"> <span class="ui-icon button ui-icon-close clear-query 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data-src="/kegg/pathway/hsa/hsa04725.png" data-situation="1x"> <input type="hidden" name="image_grayscale" value="/kegg/pathway/map/map04725.png 1x" data-src="/kegg/pathway/map/map04725.png" data-situation="1x"> <input type="hidden" name="image_grayscale" value="/kegg/pathway/map/map04725@2x.png 2x" data-src="/kegg/pathway/map/map04725@2x.png" data-situation="2x"> </form> <!-- pathway image url end --> <div id="download-menu" style="display:none;"> <div><a href="https://www.kegg.jp/kegg-bin/download?entry=hsa04725&format=kgml">KGML</a></div> <div><a class="downloadImageNx" data-scale="1" href="#downloadImage1x">Image (png) file 1x</a></div> <div><a class="downloadImageNx" data-scale="2" href="#downloadImage2x">Image (png) file 2x</a></div> </div> </body> </html>