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Lee</title> <meta name="description" content="Search results for: Bo Keun Lee"> <meta name="keywords" content="Bo Keun Lee"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Bo Keun Lee" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Bo Keun Lee"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 25</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Bo Keun Lee</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> A Trends Analysis of Yatch Simulator</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jae-Neung%20Lee">Jae-Neung Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun-Chang%20Kwak"> Keun-Chang Kwak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper describes an analysis of Yacht Simulator international trends and also explains about Yacht. Examples of yacht Simulator using Yacht Simulator include image processing for totaling the total number of vehicles, edge/target detection, detection and evasion algorithm, image processing using SIFT (scale invariant features transform) matching, and application of median filter and thresholding. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=yacht%20simulator" title="yacht simulator">yacht simulator</a>, <a href="https://publications.waset.org/abstracts/search?q=simulator" title=" simulator"> simulator</a>, <a href="https://publications.waset.org/abstracts/search?q=trends%20analysis" title=" trends analysis"> trends analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=SIFT" title=" SIFT"> SIFT</a> </p> <a href="https://publications.waset.org/abstracts/23888/a-trends-analysis-of-yatch-simulator" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23888.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">432</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> Yacht DB Construction Based on Five Essentials of Sailing </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jae-Neung%20Lee">Jae-Neung Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Myung-Won%20Lee"> Myung-Won Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Jung-Su%20Han"> Jung-Su Han</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun-Chang%20Kwak"> Keun-Chang Kwak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The paper established DB on the basis of five sailing essentials in the real yachting environment. It obtained the yacht condition (tilt, speed and course), surrounding circumstances (wind direction and speed) and user motion. Gopro camera for image processing was used to recognize the user motion and tilt sensor was employed to see the yacht balance. In addition, GPS for course, wind speed and direction sensor and marked suit were employed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DB%20consturuction" title="DB consturuction">DB consturuction</a>, <a href="https://publications.waset.org/abstracts/search?q=yacht" title=" yacht"> yacht</a>, <a href="https://publications.waset.org/abstracts/search?q=five%20essentials%20of%20sailing" title=" five essentials of sailing"> five essentials of sailing</a>, <a href="https://publications.waset.org/abstracts/search?q=marker" title=" marker"> marker</a>, <a href="https://publications.waset.org/abstracts/search?q=Gps" title=" Gps"> Gps</a> </p> <a href="https://publications.waset.org/abstracts/24841/yacht-db-construction-based-on-five-essentials-of-sailing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24841.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">461</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> Hand Gesture Recognition Interface Based on IR Camera</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yang-Keun%20Ahn">Yang-Keun Ahn</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang-Soon%20Choi"> Kwang-Soon Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Young-Choong%20Park"> Young-Choong Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang-Mo%20Jung"> Kwang-Mo Jung</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Vision based user interfaces to control TVs and PCs have the advantage of being able to perform natural control without being limited to a specific device. Accordingly, various studies on hand gesture recognition using RGB cameras or depth cameras have been conducted. However, such cameras have the disadvantage of lacking in accuracy or the construction cost being large. The proposed method uses a low cost IR camera to accurately differentiate between the hand and the background. Also, complicated learning and template matching methodologies are not used, and the correlation between the fingertips extracted through curvatures is utilized to recognize Click and Move gestures. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=recognition" title="recognition">recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=hand%20gestures" title=" hand gestures"> hand gestures</a>, <a href="https://publications.waset.org/abstracts/search?q=infrared%20camera" title=" infrared camera"> infrared camera</a>, <a href="https://publications.waset.org/abstracts/search?q=RGB%20cameras" title=" RGB cameras"> RGB cameras</a> </p> <a href="https://publications.waset.org/abstracts/13373/hand-gesture-recognition-interface-based-on-ir-camera" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13373.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">406</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> 3D Printed Multi-Modal Phantom Using Computed Tomography and 3D X-Ray Images</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sung-Suk%20Oh">Sung-Suk Oh</a>, <a href="https://publications.waset.org/abstracts/search?q=Bong-Keun%20Kang"> Bong-Keun Kang</a>, <a href="https://publications.waset.org/abstracts/search?q=Sang-Wook%20Park"> Sang-Wook Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Hui-Jin%20Joo"> Hui-Jin Joo</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong-Ryul%20Choi"> Jong-Ryul Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Seong-Jun%20Lee"> Seong-Jun Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeong-Woo%20Sohn"> Jeong-Woo Sohn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The imaging phantom is utilized for the verification, evaluation and tuning of the medical imaging device and system. Although it could be costly, 3D printing is an ideal technique for a rapid, customized, multi-modal phantom making. In this article, we propose the multi-modal phantom using 3D printing. First of all, the Dicom images for were measured by CT (Computed Tomography) and 3D X-ray systems (PET/CT and Angio X-ray system of Siemens) and then were analyzed. Finally, the 3D modeling was processed using Dicom images. The 3D printed phantom was scanned by PET/CT and MRI systems and then evaluated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=imaging%20phantom" title="imaging phantom">imaging phantom</a>, <a href="https://publications.waset.org/abstracts/search?q=MRI%20%28Magnetic%20Resonance%20Imaging%29" title=" MRI (Magnetic Resonance Imaging)"> MRI (Magnetic Resonance Imaging)</a>, <a href="https://publications.waset.org/abstracts/search?q=PET%20%2F%20CT%20%28Positron%20Emission%20Tomography%20%2F%20Computed%20Tomography%29" title=" PET / CT (Positron Emission Tomography / Computed Tomography)"> PET / CT (Positron Emission Tomography / Computed Tomography)</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title=" 3D printing "> 3D printing </a> </p> <a href="https://publications.waset.org/abstracts/62972/3d-printed-multi-modal-phantom-using-computed-tomography-and-3d-x-ray-images" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62972.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">580</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Pervaporation of Dimethyl Carbonate / Methanol / Water Mixtures Using Zeolite Membranes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jong-Ho%20Moon">Jong-Ho Moon</a>, <a href="https://publications.waset.org/abstracts/search?q=Dong-Ho%20Lee"> Dong-Ho Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyunuk%20Kim"> Hyunuk Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Young%20Cheol%20Park"> Young Cheol Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong-Seop%20Lee"> Jong-Seop Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Jae-deok%20Jeon"> Jae-deok Jeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyung-Keun%20Lee"> Hyung-Keun Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A novel membrane reactor process for DMC synthesis from carbon dioxide has been developing in Korea Institute of Energy Research. The scheme of direct synthesis of DMC from CO₂ and Methanol is 'CO₂ + 2MeOH ↔ DMC + H₂O'. Among them, reactants are CO₂ and MeOH, product is DMC, and byproduct is H₂O (water). According to Le Chatelier’s principle, removing byproduct (water) can shift the reaction equilibrium to the right (DMC production). The main purpose of this process is removing water during the reaction. For efficient in situ water removal (dehydration) and DMC separation, zeolite 4A membranes with very small pore diameter and hydrophilicity were introduced. In this study, pervaporation performances of binary and ternary DMC / methanol / water mixtures were evaluated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dimehtyl%20carbonate" title="dimehtyl carbonate">dimehtyl carbonate</a>, <a href="https://publications.waset.org/abstracts/search?q=methanol" title=" methanol"> methanol</a>, <a href="https://publications.waset.org/abstracts/search?q=water" title=" water"> water</a>, <a href="https://publications.waset.org/abstracts/search?q=zeolite%20membrane" title=" zeolite membrane"> zeolite membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=pervaporation" title=" pervaporation"> pervaporation</a> </p> <a href="https://publications.waset.org/abstracts/71361/pervaporation-of-dimethyl-carbonate-methanol-water-mixtures-using-zeolite-membranes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71361.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">362</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> Autonomous Control of Ultrasonic Transducer Drive System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dong-Keun%20Jeong">Dong-Keun Jeong</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong-Hyun%20Kim"> Jong-Hyun Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Woon-Ha%20Yoon"> Woon-Ha Yoon</a>, <a href="https://publications.waset.org/abstracts/search?q=Hee-Je%20Kim"> Hee-Je Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In order to automatically operate the ultrasonic transducer drive system for sonicating aluminum, this paper proposes the ultrasonic transducer sensorless control algorithm. The resonance frequency shift and electrical impedance change is a common phenomenon in the state of the ultrasonic transducer. The proposed control algorithm make use of the impedance change of ultrasonic transducer according to the environment between air state and aluminum alloy state, it controls the ultrasonic transducer drive system autonomous without a sensor. The proposed sensorless autonomous ultrasonic transducer control algorithm was experimentally verified using a 3kW prototype ultrasonic transducer drive system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ultrasonic%20transducer%20drive%20system" title="ultrasonic transducer drive system">ultrasonic transducer drive system</a>, <a href="https://publications.waset.org/abstracts/search?q=impedance%20change" title=" impedance change"> impedance change</a>, <a href="https://publications.waset.org/abstracts/search?q=sensorless" title=" sensorless"> sensorless</a>, <a href="https://publications.waset.org/abstracts/search?q=autonomous%20control%20algorithm" title=" autonomous control algorithm"> autonomous control algorithm</a> </p> <a href="https://publications.waset.org/abstracts/63698/autonomous-control-of-ultrasonic-transducer-drive-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63698.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Development of Detachable Brake System for Moving Apparatus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bong-Keun%20Jung">Bong-Keun Jung</a>, <a href="https://publications.waset.org/abstracts/search?q=Jung-Yeon%20Kim"> Jung-Yeon Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to investigate usability of detachable brake system for moving apparatus such as baby strollers, manual wheelchairs or walkers. The current brake system was proposed to prevent that moving apparatus slip on sloping roadways when unattended as current built-in manual brake for the moving apparatus is not able to react for the matter. The developed detachable brake system enacted by force sensor on the hand grip showed the possibilities to prevent unexpected accident due to uncontrolled stroller or wheelchair use. To investigate the quality and acceptance of this new technology, standard stroller testbed was built and the use of moving apparatus which attached to the proposed brake system was analyzed through video recording. Additional usability questionnaires were given to test users for measuring usability issues. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brake%20system" title="brake system">brake system</a>, <a href="https://publications.waset.org/abstracts/search?q=stroller" title=" stroller"> stroller</a>, <a href="https://publications.waset.org/abstracts/search?q=wheelchair" title=" wheelchair"> wheelchair</a>, <a href="https://publications.waset.org/abstracts/search?q=usability%20test" title=" usability test"> usability test</a> </p> <a href="https://publications.waset.org/abstracts/34809/development-of-detachable-brake-system-for-moving-apparatus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34809.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">738</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Physical Properties of Alkali Resistant-Glass Fibers in Continuous Fiber Spinning Conditions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ji-Sun%20Lee">Ji-Sun Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Soong-Keun%20Hyun"> Soong-Keun Hyun</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin-Ho%20Kim"> Jin-Ho Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, a glass fiber is fabricated using a continuous spinning process from alkali resistant (AR) glass with 4 wt% zirconia. In order to confirm the melting properties of the marble glass, the raw material is placed into a Pt crucible and melted at 1650 ℃ for 2 h, and then annealed. In order to confirm the transparency of the clear marble glass, the visible transmittance is measured, and the fiber spinning condition is investigated by using high temperature viscosity measurements. A change in the diameter is observed according to the winding speed in the range of 100–900 rpm; it is also verified as a function of the fiberizing temperature in the range of 1200–1260 ℃. The optimum winding speed and spinning temperature are 500 rpm and 1240 ℃, respectively. The properties of the prepared spinning fiber are confirmed using optical microscope, tensile strength, modulus, and alkali-resistant tests. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glass%20composition" title="glass composition">glass composition</a>, <a href="https://publications.waset.org/abstracts/search?q=fiber%20diameter" title=" fiber diameter"> fiber diameter</a>, <a href="https://publications.waset.org/abstracts/search?q=continuous%20filament%20fiber" title=" continuous filament fiber"> continuous filament fiber</a>, <a href="https://publications.waset.org/abstracts/search?q=continuous%20spinning" title=" continuous spinning"> continuous spinning</a>, <a href="https://publications.waset.org/abstracts/search?q=physical%20properties" title=" physical properties"> physical properties</a> </p> <a href="https://publications.waset.org/abstracts/75451/physical-properties-of-alkali-resistant-glass-fibers-in-continuous-fiber-spinning-conditions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75451.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">317</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Dual Ion-Crosslinking Human Keratin Based Bioink for 3D Bioprinting</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jae%20Seo%20Lee">Jae Seo Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Il%20Keun%20Kwon"> Il Keun Kwon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the last decades, keratin-based on natural extracts has considerably increased interest as a skin tissue regeneration. However, most parts of keratin had a limitation to 3D scaffolds due to low biological affinity and general low mechanical properties. To create a 3D structure, a facile bioink was designed with a photocurable crosslinking stage system using natural polymer-based human keratin. Keratin-based bioink enables the crosslinking more quickly through two types of photo and ion crosslinking for module engineering assembly. Rheological results showed that keratin-based bioink with high concentration possessed superior mechanical rigidity for 3D bioprinting. Different 3D geometrically constructs were successfully fabricated with optimal bioprinting parameters through the 3D printer with X-Y-Z controlled UV laser system. The presented study has offered a distinct advantage for 3D printing of keratin-based hydrogel into 3D complex-shaped biomimetic constructs. Thus, keratin-based bioink opens up new avenues in bioprinting to directly substitute tissue or organs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20keratin" title="human keratin">human keratin</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=ion-crosslinking" title=" ion-crosslinking"> ion-crosslinking</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20bioprinting" title=" 3D bioprinting"> 3D bioprinting</a> </p> <a href="https://publications.waset.org/abstracts/126297/dual-ion-crosslinking-human-keratin-based-bioink-for-3d-bioprinting" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/126297.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">124</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Two-Step Patterning of Microfluidic Structures in Paper by Laser Cutting and Wax Printing for Mass Fabrication of Biosensor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bong%20Keun%20Kang">Bong Keun Kang</a>, <a href="https://publications.waset.org/abstracts/search?q=Sung%20Suk%20Oh"> Sung Suk Oh</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeong-Woo%20Sohn"> Jeong-Woo Sohn</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong-Ryul%20Choi"> Jong-Ryul Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Young%20Ho%20Kim"> Young Ho Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, we describe two-step micro-pattering by using laser cutting and wax printing. Wax printing is performed only on the bridges for hydrophobic barriers. We prepared 405nm blue-violet laser module and wax pencil module. And, this two modules combine x-y plot. The hollow microstructure formed by laser patterning define the hydrophilic flowing paths. However, bridges are essential to avoid the cutting area being the island. Through the support bridges, microfluidic solution spread out to the unnecessary areas. Chromatography blotting paper was purchased from Whatman. We used 20x20 cm and 46x57 cm of chromatography blotting paper. Axis moving speed of x-y plot was the main parameter of optimization. For aligning between the two patterning, the paper sheet was taped at the bottom. After the two-step patterning, temperature curing step was done at 110-130 °C. The resolution of the fabrication and the potential of the multiplex detection were investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%C2%B5PADs" title="µPADs">µPADs</a>, <a href="https://publications.waset.org/abstracts/search?q=microfluidic" title=" microfluidic"> microfluidic</a>, <a href="https://publications.waset.org/abstracts/search?q=biosensor" title=" biosensor"> biosensor</a>, <a href="https://publications.waset.org/abstracts/search?q=mass-fabrication" title=" mass-fabrication"> mass-fabrication</a> </p> <a href="https://publications.waset.org/abstracts/62844/two-step-patterning-of-microfluidic-structures-in-paper-by-laser-cutting-and-wax-printing-for-mass-fabrication-of-biosensor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62844.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">467</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Knowledge Representation Based on Interval Type-2 CFCM Clustering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lee%20Myung-Won">Lee Myung-Won</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwak%20Keun-Chang"> Kwak Keun-Chang </a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper is concerned with knowledge representation and extraction of fuzzy if-then rules using Interval Type-2 Context-based Fuzzy C-Means clustering (IT2-CFCM) with the aid of fuzzy granulation. This proposed clustering algorithm is based on information granulation in the form of IT2 based Fuzzy C-Means (IT2-FCM) clustering and estimates the cluster centers by preserving the homogeneity between the clustered patterns from the IT2 contexts produced in the output space. Furthermore, we can obtain the automatic knowledge representation in the design of Radial Basis Function Networks (RBFN), Linguistic Model (LM), and Adaptive Neuro-Fuzzy Networks (ANFN) from the numerical input-output data pairs. We shall focus on a design of ANFN in this paper. The experimental results on an estimation problem of energy performance reveal that the proposed method showed a good knowledge representation and performance in comparison with the previous works. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=IT2-FCM" title="IT2-FCM">IT2-FCM</a>, <a href="https://publications.waset.org/abstracts/search?q=IT2-CFCM" title=" IT2-CFCM"> IT2-CFCM</a>, <a href="https://publications.waset.org/abstracts/search?q=context-based%20fuzzy%20clustering" title=" context-based fuzzy clustering"> context-based fuzzy clustering</a>, <a href="https://publications.waset.org/abstracts/search?q=adaptive%20neuro-fuzzy%20network" title=" adaptive neuro-fuzzy network"> adaptive neuro-fuzzy network</a>, <a href="https://publications.waset.org/abstracts/search?q=knowledge%20representation" title=" knowledge representation"> knowledge representation</a> </p> <a href="https://publications.waset.org/abstracts/28945/knowledge-representation-based-on-interval-type-2-cfcm-clustering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28945.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">322</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> 3D Printing of Cold Atmospheric Plasma Treated Poly(ɛ-Caprolactone) for Bone Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dong%20Nyoung%20Heo">Dong Nyoung Heo</a>, <a href="https://publications.waset.org/abstracts/search?q=Il%20Keun%20Kwon"> Il Keun Kwon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Three-dimensional (3D) technology is a promising method for bone tissue engineering. In order to enhance bone tissue regeneration, it is important to have ideal 3D constructs with biomimetic mechanical strength, structure interconnectivity, roughened surface, and the presence of chemical functionality. In this respect, a 3D printing system combined with cold atmospheric plasma (CAP) was developed to fabricate a 3D construct that has a rough surface with polar functional chemical groups. The CAP-etching process leads to oxidation of chemical groups existing on the polycaprolactone (PCL) surface without conformational change. The surface morphology, chemical composition, mean roughness of the CAP-treated PCL surfaces were evaluated. 3D printed constructs composed of CAP-treated PCL showed an effective increment in the hydrophilicity and roughness of the PCL surface. Also, an in vitro study revealed that CAP-treated 3D PCL constructs had higher cellular behaviors such as cell adhesion, cell proliferation, and osteogenic differentiation. Therefore, a 3D printing system with CAP can be a highly useful fabrication method for bone tissue regeneration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone%20tissue%20engineering" title="bone tissue engineering">bone tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=cold%20atmospheric%20plasma" title=" cold atmospheric plasma"> cold atmospheric plasma</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title=" 3D printing"> 3D printing</a> </p> <a href="https://publications.waset.org/abstracts/126200/3d-printing-of-cold-atmospheric-plasma-treated-poly-caprolactone-for-bone-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/126200.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">114</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Evaluation of Shock Sensitivity of Nano-Scaled 1,3,5-Trinitro-1,3,5-Triazacyclohexane Using Small Scale Gap Test</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kang-In%20Lee">Kang-In Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Woo-Jin%20Lee"> Woo-Jin Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun-Deuk%20Lee"> Keun-Deuk Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Ju-Seung%20Chae"> Ju-Seung Chae</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, small scale gap test (SSGT) was performed to measure shock sensitivity of nano-scaled 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) samples. The shock sensitivity of energetic materials is usually evaluated by the method of large-scale gap test (LSGT) that has a higher reliability than other methods. But LSGT has the disadvantage that it takes a high cost and time by using a large amount of explosive. In this experiment, nano-scaled RDX samples were prepared by spray crystallization in two different drying methods. In addition, 30μm RDX sample produced by precipitation crystallization and 5μm RDX sample produced by fluid energy mill process were tested to compare shock sensitivity. The study of shock sensitivity measured by small-scale gap test shows that small sized RDX particles have greater insensitivity. As a result, we infer SSGT method has higher reliability compared to the literature as measurement of shock sensitivity of energetic materials. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nano-scaled%20RDX" title="nano-scaled RDX">nano-scaled RDX</a>, <a href="https://publications.waset.org/abstracts/search?q=SSGT%28small%20scale%20gap%20test%29" title=" SSGT(small scale gap test)"> SSGT(small scale gap test)</a>, <a href="https://publications.waset.org/abstracts/search?q=shock%20sensitivity" title=" shock sensitivity"> shock sensitivity</a>, <a href="https://publications.waset.org/abstracts/search?q=RDX" title=" RDX"> RDX</a> </p> <a href="https://publications.waset.org/abstracts/73492/evaluation-of-shock-sensitivity-of-nano-scaled-135-trinitro-135-triazacyclohexane-using-small-scale-gap-test" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/73492.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">258</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> A Study of Adaptive Fault Detection Method for GNSS Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Je%20Young%20Lee">Je Young Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hee%20Sung%20Kim"> Hee Sung Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang%20Ho%20Choi"> Kwang Ho Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Joonhoo%20Lim"> Joonhoo Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Sebum%20Chun"> Sebum Chun</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyung%20Keun%20Lee"> Hyung Keun Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A purpose of this study is to develop efficient detection method for Global Navigation Satellite Systems (GNSS) applications based on adaptive estimation. Due to dependence of radio frequency signals, GNSS measurements are dominated by systematic errors in receiver’s operating environment. Thus, to utilize GNSS for aerospace or ground vehicles requiring high level of safety, unhealthy measurements should be considered seriously. For the reason, this paper proposes adaptive fault detection method to deal with unhealthy measurements in various harsh environments. By the proposed method, the test statistics for fault detection is generated by estimated measurement noise. Pseudorange and carrier-phase measurement noise are obtained at time propagations and measurement updates in process of Carrier-Smoothed Code (CSC) filtering, respectively. Performance of the proposed method was evaluated by field-collected GNSS measurements. To evaluate the fault detection capability, intentional faults were added to measurements. The experimental result shows that the proposed detection method is efficient in detecting unhealthy measurements and improves the accuracy of GNSS positioning under fault occurrence. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adaptive%20estimation" title="adaptive estimation">adaptive estimation</a>, <a href="https://publications.waset.org/abstracts/search?q=fault%20detection" title=" fault detection"> fault detection</a>, <a href="https://publications.waset.org/abstracts/search?q=GNSS" title=" GNSS"> GNSS</a>, <a href="https://publications.waset.org/abstracts/search?q=residual" title=" residual"> residual</a> </p> <a href="https://publications.waset.org/abstracts/19306/a-study-of-adaptive-fault-detection-method-for-gnss-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19306.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">576</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Effects of β-Glucan on the Release of Nitric Oxide by RAW264.7 Cells Stimulated with Escherichia coli Lipopolysaccharide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eun%20Young%20Choi">Eun Young Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=So%20Hui%20Choe"> So Hui Choe</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin%20Yi%20Hyeon"> Jin Yi Hyeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji%20Young%20Jin"> Ji Young Jin</a>, <a href="https://publications.waset.org/abstracts/search?q=Bo%20Ram%20Keum"> Bo Ram Keum</a>, <a href="https://publications.waset.org/abstracts/search?q=Jong%20Min%20Lim"> Jong Min Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyung%20Rae%20Cho"> Hyung Rae Cho</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang%20Keun%20Cho"> Kwang Keun Cho</a>, <a href="https://publications.waset.org/abstracts/search?q=In%20Soon%20Choi"> In Soon Choi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research analyzed the effect of β-glucan that is expected to alleviate the production of inflammatory mediator in macrophagocyte, which was processed by the lipopolysaccharide (LPS) of Escherichia, a pathogen related to allergy. The incubated layer was used for nitric oxide (NO) analysis. The DNA-binding activation of the small unit of NF-κB was measured using ELISA-based kit. In RAW264.7 cells that were vitalized by E.coli LPS, β-glucan inhibited both the combatant and rendering phases of inducible NO synthase (iNOS)-derived NO. β-glucan increased the expression of heme oxygenase-1 (HO-1) in the cell that was stimulated by E.coli LPS, and HO-1 activation was inhibited by SnPP. This shows that NO production induced by LPS is related to the inhibition effect of β-glucan. The phosphorylation of JNK and p38 induced by LPS were not influenced by β-glucan, and IκB-α decomposition was not influenced either. Instead, β-glucan remarkably inhibited the phosphorylation of STAT1 that was induced by E.coli LPS. Overall, β-glucan inhibited the production of NO in macrophagocyte that was vitalized by E.coli LPS through HO-1 induction and STAT1 pathways inhibition in this research. As the host inflammation reaction control by β-glucan weakens the progress of allergy, β-glucan can be used as an effective treatment method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%CE%B2-glucan" title="β-glucan">β-glucan</a>, <a href="https://publications.waset.org/abstracts/search?q=lipopolysaccharide%20%28LPS%29" title=" lipopolysaccharide (LPS)"> lipopolysaccharide (LPS)</a>, <a href="https://publications.waset.org/abstracts/search?q=nitric%20oxide%20%28NO%29" title=" nitric oxide (NO)"> nitric oxide (NO)</a>, <a href="https://publications.waset.org/abstracts/search?q=RAW264.7%20cells" title=" RAW264.7 cells"> RAW264.7 cells</a>, <a href="https://publications.waset.org/abstracts/search?q=STAT1" title=" STAT1"> STAT1</a> </p> <a href="https://publications.waset.org/abstracts/49496/effects-of-v-glucan-on-the-release-of-nitric-oxide-by-raw2647-cells-stimulated-with-escherichia-coli-lipopolysaccharide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49496.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">408</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Analysis of Replication Protein A (RPA): The Role of Homolog Interaction and Recombination during Meiosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jeong%20Hwan%20Joo">Jeong Hwan Joo</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun%20Pil%20Kim"> Keun Pil Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> During meiosis, meiotic recombination is initiated by Spo11-mediated DSB formation and exonuclease-mediated DSB resection occurs to expose single stranded DNA formation. RPA is further required to inhibit secondary structure formation of ssDNA that can be formed Watson-Crick pairing. Rad51-Dmc1, RecA homologs in eukaryote and their accessory factors involve in searching homolog templates to mediate strand exchange. In this study, we investigate the recombinational roles of replication protein A (RPA), which is heterotrimeric protein that is composed of RPA1, RPA2, and RPA3. Here, we investigated meiotic recombination using DNA physical analysis at the HIS4LEU2 hot spot. In rfa1-119 (K45E, N316S) cells, crossover (CO) and non-crossover (NCO) products reduced than WT. rfa1-119 delayed in single end invasion-to-double holiday junction (SEI-to-dHJ) transition and exhibits a defect in second-end capture that is also modulated by Rad52. In the further experiment, we observed that in rfa1-119 mutant, RPA could not be released in timely manner. Furthermore, rfa1-119 exhibits failure in the second end capture, implying reduction of COs and NCOs. In this talk, we will discuss more detail how RPA involves in chromatin axis association via formation of axis-bridge and why RPA is required for Rad52-mediated second-end capture progression. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=homolog%20interaction" title="homolog interaction">homolog interaction</a>, <a href="https://publications.waset.org/abstracts/search?q=meiotic%20recombination" title=" meiotic recombination"> meiotic recombination</a>, <a href="https://publications.waset.org/abstracts/search?q=replication%20protein%20A" title=" replication protein A"> replication protein A</a>, <a href="https://publications.waset.org/abstracts/search?q=RPA1" title=" RPA1"> RPA1</a> </p> <a href="https://publications.waset.org/abstracts/80585/analysis-of-replication-protein-a-rpa-the-role-of-homolog-interaction-and-recombination-during-meiosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80585.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Structural Analysis of Hole-Type Plate for Weight Lightening of Road Sign</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Joon-Yeop%20Na">Joon-Yeop Na</a>, <a href="https://publications.waset.org/abstracts/search?q=Sang-Keun%20Baik"> Sang-Keun Baik</a>, <a href="https://publications.waset.org/abstracts/search?q=Kyu-Soo%20Chong"> Kyu-Soo Chong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Road sign sizes are related to their support and foundation, and the large-scale support that is generally installed at roadsides can cause inconvenience to pedestrians and damage the urban landscape. The most influential factor in determining the support and foundation of road signs is the wind load. In this study, we introduce a hole-type road sign to analyze its effects on reducing wind load. A hole-type road sign reduces the drag coefficient that is applied when considering the air and fluid resistance of a plate when the wind pressure is calculated, thus serving as an effective option for lightening the weights of road sign structures. A hole-type road sign is punctured with a perforator. Furthermore, the size of the holes and their distance is determined considering the damage to characters, the poor performance of reflective sheets, and legibility. For the calculation of the optimal specification of a hole-type road sign, we undertook a theoretical examination for reducing the wind loads on hole-type road signs, and analyzed the bending and reflectivity of sample road sign plates. The analytic results confirmed that a hole-type road sign sample that contains holes of 6 mm in diameter with a distance of 18 mm between the holes shows reflectivity closest to that of existing road signs; moreover, the average bending moment resulted in a reduction of 4.24%, and the support’s diameter is reduced by 40.2%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hole%20type" title="hole type">hole type</a>, <a href="https://publications.waset.org/abstracts/search?q=road%20sign" title=" road sign"> road sign</a>, <a href="https://publications.waset.org/abstracts/search?q=weight%20lightening" title=" weight lightening"> weight lightening</a>, <a href="https://publications.waset.org/abstracts/search?q=wind%20load" title=" wind load"> wind load</a> </p> <a href="https://publications.waset.org/abstracts/11317/structural-analysis-of-hole-type-plate-for-weight-lightening-of-road-sign" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/11317.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">546</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Efficient Delivery of Biomaterials into Living Organism by Using Noble Metal Nanowire Injector</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kkochorong%20Park">Kkochorong Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun%20Cheon%20Kim"> Keun Cheon Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hyoban%20Lee"> Hyoban Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Eun%20Ju%20Lee"> Eun Ju Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Bongsoo%20Kim"> Bongsoo Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction of biomaterials such as DNA, RNA, proteins is important for many research areas. There are many methods to introduce biomaterials into living organisms like tissue and cells. To introduce biomaterials, several indirect methods including virus‐mediated delivery, chemical reagent (i.e., lipofectamine), electrophoresis have been used. Such methods are passive delivery using an endocytosis process of cell, reducing an efficiency of delivery. Unlike the indirect delivery method, it has been reported that a direct delivery of exogenous biomolecules into nucleus have been more efficient to expression or integration of biomolecules. Nano-sized material is beneficial for detect signal from cell or deliver stimuli/materials into the cell at cellular and molecular levels, due to its similar physical scale. Especially, because 1 dimensional (1D) nanomaterials such as nanotube, nanorod and nanowire with high‐aspect ratio have nanoscale geometry and excellent mechanical, electrical, and chemical properties, they could play an important role in molecular and cellular biology. In this study, by using single crystalline 1D noble metal nanowire, we fabricated nano-sized 1D injector which can successfully interface with living cells and directly deliver biomolecules into several types of cell line (i.e., stem cell, mammalian embryo) without inducing detrimental damages on living cell. This nano-bio technology could be a promising and robust tool for introducing exogenous biomaterials into living organism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DNA" title="DNA">DNA</a>, <a href="https://publications.waset.org/abstracts/search?q=gene%20delivery" title=" gene delivery"> gene delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoinjector" title=" nanoinjector"> nanoinjector</a>, <a href="https://publications.waset.org/abstracts/search?q=nanowire" title=" nanowire"> nanowire</a> </p> <a href="https://publications.waset.org/abstracts/62718/efficient-delivery-of-biomaterials-into-living-organism-by-using-noble-metal-nanowire-injector" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62718.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">275</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Prospective Study to Determine the Efficacy of Day Hospital Care to Improve Treatment Adherence for Hospitalized Schizophrenic Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jin%20Hun%20Choi">Jin Hun Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=So%20Hyun%20Ahn"> So Hyun Ahn</a>, <a href="https://publications.waset.org/abstracts/search?q=Seong%20Keun%20Wang"> Seong Keun Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ik-Seung%20Chee"> Ik-Seung Chee</a>, <a href="https://publications.waset.org/abstracts/search?q=Jung%20Lan%20Kim"> Jung Lan Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Sun%20Woo%20Lee"> Sun Woo Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: The purpose of the study is to investigate the effects of day hospital care in hospitalized schizophrenic patients in terms of treatment adherence and treatment outcomes. Methods: Among schizophrenic patients hospitalized between 2011 and 2012, 23 day hospital care patient and 40 control subjects were included in the study. All candidates underwent Beck Cognitive Insight Scale, Drug Attitude Inventory, World Health Organization Quality of Life Assessment and Psychological Well-Being Scale when their symptoms were stabilized during hospitalization, and after being discharged, 23 patients received day hospital care for two months and then changed to out-patient care while 40 patients received out-patient care immediately after discharge. At the point of two months of out-patient care, the treatment adherence of the two groups was evaluated; tracking observation was performed until February, 2013, and survival rates were compared between the two groups. Results: Treatment adherence was higher in the day hospital care group than in the control group. Kaplan-Meier survival analysis showed a higher survival rate for the day hospital care group compared to the control group. Levels of cognitive insight and quality of life were higher after day hospital care than before day hospital care in the day hospital care group. Conclusions: Through the study, it was confirmed that when hospitalized schizophrenic patients received continuous day hospital care after being discharged, they received further out-patient care more faithfully. The study is considered to aid in the understanding regarding schizophrenic patients’ treatment adherence issues and improvement of treatment outcomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=schizophrenia" title="schizophrenia">schizophrenia</a>, <a href="https://publications.waset.org/abstracts/search?q=day%20hospital%20care" title=" day hospital care"> day hospital care</a>, <a href="https://publications.waset.org/abstracts/search?q=adherence" title=" adherence"> adherence</a>, <a href="https://publications.waset.org/abstracts/search?q=outcomes" title=" outcomes"> outcomes</a> </p> <a href="https://publications.waset.org/abstracts/54839/prospective-study-to-determine-the-efficacy-of-day-hospital-care-to-improve-treatment-adherence-for-hospitalized-schizophrenic-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54839.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">353</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> L-Carnitine vs Extracorporeal Elimination for Acute Valproic Acid Intoxication: A Systemic Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Byung%20Keun%20Yang">Byung Keun Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Jae%20Eun%20Ku"> Jae Eun Ku</a>, <a href="https://publications.waset.org/abstracts/search?q=Young%20Seon%20Joo"> Young Seon Joo</a>, <a href="https://publications.waset.org/abstracts/search?q=Je%20Sung%20You"> Je Sung You</a>, <a href="https://publications.waset.org/abstracts/search?q=Sung%20Phil%20Chung"> Sung Phil Chung</a>, <a href="https://publications.waset.org/abstracts/search?q=Hahn%20Shick%20Lee"> Hahn Shick Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of this study is to review the evidence comparing the efficacy and safety between L-carnitine and extracorporeal elimination therapy in the management of acute valproic acid L-carnitine vs Extracorporeal Elimination for Acute Valproic acid Intoxication. PubMed, Embase, Cochrane library, Web of Science, KoreaMed, KMbase, and KISS were searched, using the terms carnitine and valproic acid. All studies, regardless of design, reporting efficacy or safety endpoints were included. Reference citations from identified publications were reviewed. Both English and Korean languages were included. Two authors extracted primary data elements including poisoning severity, presenting features, clinical management, and outcomes. Thirty two articles including 33 cases were identified. Poisoning severity was classified as 3 mild, 11 moderate, and 19 severe cases. Nine cases were treated with L-carnitine while 24 cases received extracorporeal therapy without L-carnitine. All patients except one expired patient treated with hemodialysis recovered clinically and no adverse effects were noted. A case report comparing two patients who ingested the same amount of valproic acid showed increased ICU stay (3 vs. 11 days) in case of delayed extracorporeal therapy. Published evidence comparing L-carnitine with extracorporeal therapy is limited. Based on the available evidence, it is reasonable to consider L-carnitine for patients with acute valproic acid overdose. In case of severe poisoning, extracorporeal therapy would also be considered in the early phase of treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carnitine" title="carnitine">carnitine</a>, <a href="https://publications.waset.org/abstracts/search?q=overdose" title=" overdose"> overdose</a>, <a href="https://publications.waset.org/abstracts/search?q=poisoning" title=" poisoning"> poisoning</a>, <a href="https://publications.waset.org/abstracts/search?q=renal%20dialysis" title=" renal dialysis"> renal dialysis</a>, <a href="https://publications.waset.org/abstracts/search?q=valproic%20acid" title=" valproic acid"> valproic acid</a> </p> <a href="https://publications.waset.org/abstracts/40639/l-carnitine-vs-extracorporeal-elimination-for-acute-valproic-acid-intoxication-a-systemic-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40639.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">367</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Receptor-Independent Effects of Endocannabinoid Anandamide on Contractility and Electrophysiological Properties of Rat Ventricular Myocytes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lina%20T.%20Al%20Kury">Lina T. Al Kury</a>, <a href="https://publications.waset.org/abstracts/search?q=Oleg%20I.%20Voitychuk"> Oleg I. Voitychuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramiz%20M.%20Ali"> Ramiz M. Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Sehamuddin%20Galadari"> Sehamuddin Galadari</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun-Hang%20Susan%20Yang"> Keun-Hang Susan Yang</a>, <a href="https://publications.waset.org/abstracts/search?q=Frank%20Christopher%20Howarth"> Frank Christopher Howarth</a>, <a href="https://publications.waset.org/abstracts/search?q=Yaroslav%20M.%20Shuba"> Yaroslav M. Shuba</a>, <a href="https://publications.waset.org/abstracts/search?q=Murat%20Oz"> Murat Oz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A role for anandamide (N-arachidonoyl ethanolamide; AEA), a major endocannabinoid, in the cardiovascular system in various pathological conditions has been reported in earlier studies. In the present work, we have hypothesized that the antiarrhythmic effects reported for AEA are due to its negative inotropic effect and altered action potential (AP) characteristics. Therefore, we tested the effects of AEA on contractility and electrophysiological properties of rat ventricular myocytes. Video edge detection was used to measure myocyte shortening. Intracellular Ca2+ was measured in cells loaded with the fluorescent indicator fura-2 AM. Whole-cell patch-clamp technique was employed to investigate the effect of AEA on the characteristics of APs. AEA (1 μM) caused a significant decrease in the amplitudes of electrically-evoked myocyte shortening and Ca2+ transients and significantly decreased the duration of AP. The effect of AEA on myocyte shortening and AP characteristics was not altered in the presence of pertussis toxin (PTX, 2 µg/ml for 4 h), AM251 and SR141716 (cannabinoid type 1 receptor antagonists) or AM630 and SR 144528 (cannabinoid type 2 receptor antagonists). Furthermore, AEA inhibited voltage-activated inward Na+ (INa) and Ca2+ (IL,Ca) currents; major ionic currents shaping the APs in ventricular myocytes, in a voltage and PTX-independent manner. Collectively, the results suggest that AEA depresses ventricular myocyte contractility, by decreasing the action potential duration (APD), and inhibits the function of voltage-dependent Na+ and L-type Ca2+ channels in a manner independent of cannabinoid receptors. This mechanism may be importantly involved in the antiarrhythmic effects of anandamide. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=action%20potential" title="action potential">action potential</a>, <a href="https://publications.waset.org/abstracts/search?q=anandamide" title=" anandamide"> anandamide</a>, <a href="https://publications.waset.org/abstracts/search?q=cannabinoid%20receptor" title=" cannabinoid receptor"> cannabinoid receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=endocannabinoid" title=" endocannabinoid"> endocannabinoid</a>, <a href="https://publications.waset.org/abstracts/search?q=ventricular%20myocytes" title=" ventricular myocytes"> ventricular myocytes</a> </p> <a href="https://publications.waset.org/abstracts/39250/receptor-independent-effects-of-endocannabinoid-anandamide-on-contractility-and-electrophysiological-properties-of-rat-ventricular-myocytes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39250.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">355</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Understanding Inhibitory Mechanism of the Selective Inhibitors of Cdk5/p25 Complex by Molecular Modeling Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amir%20Zeb">Amir Zeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Shailima%20Rampogu"> Shailima Rampogu</a>, <a href="https://publications.waset.org/abstracts/search?q=Minky%20Son"> Minky Son</a>, <a href="https://publications.waset.org/abstracts/search?q=Ayoung%20Baek"> Ayoung Baek</a>, <a href="https://publications.waset.org/abstracts/search?q=Sang%20H.%20Yoon"> Sang H. Yoon</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun%20W.%20Lee"> Keun W. Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Neurotoxic insults activate calpain, which in turn produces truncated p25 from p35. p25 forms hyperactivated Cdk5/p25 complex, and thereby induces severe neuropathological aberrations including hyperphosphorylated tau, neuroinflammation, apoptosis, and neuronal death. Inhibition of Cdk5/p25 complex alleviates aberrant phosphorylation of tau to mitigate AD pathology. PHA-793887 and Roscovitine have been investigated as selective inhibitors of Cdk5/p25 with IC50 values 5nM and 160nM, respectively, but their mechanistic studies remain unknown. Herein, computational simulations have explored the binding mode and interaction mechanism of PHA-793887 and Roscovitine with Cdk5/p25. Docking results suggested that PHA-793887 and Rsocovitine have occupied the ATP-binding site of Cdk5 and obtained highest docking (GOLD) score of 66.54 and 84.03, respectively. Furthermore, molecular dynamics (MD) simulation demonstrated that PHA-793887 and Roscovitine established stable RMSD of 1.09 Å and 1.48 Å with Cdk5/p25, respectively. Profiling of polar interactions suggested that each inhibitor formed hydrogen bonds (H-bond) with catalytic residues of Cdk5 and could remain stable throughout the molecular dynamics simulation. Additionally, binding free energy calculation by molecular mechanics/Poisson–Boltzmann surface area (MM/PBSA) suggested that PHA-793887 and Roscovitine had lowest binding free energies of -150.05 kJ/mol and -113.14 kJ/mol, respectively with Cdk5/p25. Free energy decomposition demonstrated that polar energy by H-bond between the Glu81 of Cdk5 and PHA-793887 is the essential factor to make PHA-793887 highly selective towards Cdk5/p25. Overall, this study provided substantial evidences to explore mechanistic interactions of the selective inhibitors of Cdk5/p25 and could be used as fundamental considerations in the development of structure-based selective inhibitors of Cdk5/p25. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cdk5%2Fp25%20inhibition" title="Cdk5/p25 inhibition">Cdk5/p25 inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling%20of%20Cdk5%2Fp25" title=" molecular modeling of Cdk5/p25"> molecular modeling of Cdk5/p25</a>, <a href="https://publications.waset.org/abstracts/search?q=PHA-793887%20and%20roscovitine" title=" PHA-793887 and roscovitine"> PHA-793887 and roscovitine</a>, <a href="https://publications.waset.org/abstracts/search?q=selective%20inhibition%20of%20Cdk5%2Fp25" title=" selective inhibition of Cdk5/p25"> selective inhibition of Cdk5/p25</a> </p> <a href="https://publications.waset.org/abstracts/104750/understanding-inhibitory-mechanism-of-the-selective-inhibitors-of-cdk5p25-complex-by-molecular-modeling-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/104750.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">139</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Power Quality Modeling Using Recognition Learning Methods for Waveform Disturbances</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sang-Keun%20Moon">Sang-Keun Moon</a>, <a href="https://publications.waset.org/abstracts/search?q=Hong-Rok%20Lim"> Hong-Rok Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin-O%20Kim"> Jin-O Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents a Power Quality (PQ) modeling and filtering processes for the distribution system disturbances using recognition learning methods. Typical PQ waveforms with mathematical applications and gathered field data are applied to the proposed models. The objective of this paper is analyzing PQ data with respect to monitoring, discriminating, and evaluating the waveform of power disturbances to ensure the system preventative system failure protections and complex system problem estimations. Examined signal filtering techniques are used for the field waveform noises and feature extractions. Using extraction and learning classification techniques, the efficiency was verified for the recognition of the PQ disturbances with focusing on interactive modeling methods in this paper. The waveform of selected 8 disturbances is modeled with randomized parameters of IEEE 1159 PQ ranges. The range, parameters, and weights are updated regarding field waveform obtained. Along with voltages, currents have same process to obtain the waveform features as the voltage apart from some of ratings and filters. Changing loads are causing the distortion in the voltage waveform due to the drawing of the different patterns of current variation. In the conclusion, PQ disturbances in the voltage and current waveforms indicate different types of patterns of variations and disturbance, and a modified technique based on the symmetrical components in time domain was proposed in this paper for the PQ disturbances detection and then classification. Our method is based on the fact that obtained waveforms from suggested trigger conditions contain potential information for abnormality detections. The extracted features are sequentially applied to estimation and recognition learning modules for further studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=power%20quality%20recognition" title="power quality recognition">power quality recognition</a>, <a href="https://publications.waset.org/abstracts/search?q=PQ%20modeling" title=" PQ modeling"> PQ modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=waveform%20feature%20extraction" title=" waveform feature extraction"> waveform feature extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=disturbance%20trigger%20condition" title=" disturbance trigger condition"> disturbance trigger condition</a>, <a href="https://publications.waset.org/abstracts/search?q=PQ%20signal%20filtering" title=" PQ signal filtering"> PQ signal filtering</a> </p> <a href="https://publications.waset.org/abstracts/83473/power-quality-modeling-using-recognition-learning-methods-for-waveform-disturbances" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/83473.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">186</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Preparation and Evaluation of Poly(Ethylene Glycol)-B-Poly(Caprolactone) Diblock Copolymers with Zwitterionic End Group for Thermo-Responsive Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bo%20Keun%20Lee">Bo Keun Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Doo%20Yeon%20Kwon"> Doo Yeon Kwon</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji%20Hoon%20Park"> Ji Hoon Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Gun%20Hee%20Lee"> Gun Hee Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji%20Hye%20Baek"> Ji Hye Baek</a>, <a href="https://publications.waset.org/abstracts/search?q=Heung%20Jae%20Chun"> Heung Jae Chun</a>, <a href="https://publications.waset.org/abstracts/search?q=Young%20Joo%20Koh"> Young Joo Koh</a>, <a href="https://publications.waset.org/abstracts/search?q=Moon%20Suk%20Kim"> Moon Suk Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Thermo-responsive materials are viscoelastic materials that undergo a sol-to-gel phase transition at a specific temperature and many materials have been developed. MPEG-b-PCL (MPC) as a thermo-responsive material contained hydrophilic and hydrophobic segments and it formed an ordered crystalline structure of hydrophobic PCL segments in aqueous solutions. The ordered crystalline structure packed tightly or aggregated and finally induced an aggregated gel through intra- and inter-molecular interactions as a function of temperature. Thus, we introduced anionic and cationic groups into the end positions of the PCL chain to alter the hydrophobicity of the PCL segment. Introducing anionic and cationic groups into the PCL end position altered their solubility by changing the crystallinity and hydrophobicity of the PCL block domains. These results indicated that the properties of the end group in the hydrophobic PCL blockand the balance between hydrophobicity and hydrophilicity affect thermo-responsivebehavior of the copolymers in aqueous solutions. Thus, we concluded that determinant of the temperature-dependent thermo-responsive behavior of MPC depend on the ionic end group in the PCL block. So, we introduced zwitterionic end groups to investigate the thermo-responsive behavior of MPC. Methoxypoly(ethylene oxide) and ε-caprolactone (CL) were randomly copolymerized that introduced varying hydrophobic PCL lengths and an MPC featuring a zwitterionic sulfobetaine (MPC-ZW) at the chain end of the PCL segment. The MPC and MPC-ZW copolymers were obtained formed sol-state at room temperature when prepared as 20-wt% aqueous solutions. The solubility of MPC decreased when the PCL block was increased from molecular weight. The solubilization time of MPC-2.4k was around 20 min and MPC-2.8k, MPC-3.0k increased to 30 min and 1 h, respectively. MPC-3.6k was not solubilized. In case of MPC-ZW 3.6k, However, the zwitterion-modified MPC copolymers were solubilized in 3–5 min. This result indicates that the zwitterionic end group of the MPC-ZW diblock copolymer increased the aqueous solubility of the diblock copolymer even when the length of the hydrophobic PCL segment was increased. MPC and MPC-ZW diblock copolymers that featuring zwitterionic end groups were synthesized successfully. The sol-to-gel phase-transition was formed that specific temperature depend on the length of the PCL hydrophobic segments introduced and on the zwitterion groups attached to the MPC chain end. This result indicated that the zwitterionic end groups reduced the hydrophobicity in the PCL block and changed the solubilization. The MPC-ZW diblock copolymer can be utilized as a potential injectable drug and cell carrier. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thermo-responsive%20material" title="thermo-responsive material">thermo-responsive material</a>, <a href="https://publications.waset.org/abstracts/search?q=zwitterionic" title=" zwitterionic"> zwitterionic</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title=" hydrophobic"> hydrophobic</a>, <a href="https://publications.waset.org/abstracts/search?q=crystallization" title=" crystallization"> crystallization</a>, <a href="https://publications.waset.org/abstracts/search?q=phase%20transition" title=" phase transition"> phase transition</a> </p> <a href="https://publications.waset.org/abstracts/9288/preparation-and-evaluation-of-polyethylene-glycol-b-polycaprolactone-diblock-copolymers-with-zwitterionic-end-group-for-thermo-responsive-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9288.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">507</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Effect of Synbiotics on Rats' Intestinal Microbiota</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Da%20Yoon%20Yu">Da Yoon Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeong%20A.%20Kim"> Jeong A. Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=In%20Sung%20Kim"> In Sung Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Yeon%20Hee%20Hong"> Yeon Hee Hong</a>, <a href="https://publications.waset.org/abstracts/search?q=Jae%20Young%20Kim"> Jae Young Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Sang%20Suk%20Lee"> Sang Suk Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Sung%20Chan%20Kim"> Sung Chan Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=So%20Hui%20Choe"> So Hui Choe</a>, <a href="https://publications.waset.org/abstracts/search?q=In%20Soon%20Choi"> In Soon Choi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwang%20Keun%20Cho"> Kwang Keun Cho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was conducted to identify the effects of synbiotics composed of lactic acid (LA) bacteria (LAB) and sea tangle on rat’s intestinal microorganisms and anti-obesity effects. The experiment was conducted for six weeks using an 8-week old male rat as experiment animals and the experimental design was to use six treatments groups of 4 repetitions using three mice per repetition. The treatment groups were organized into a normal fat diet control (NFC), a high fat (HF) diet control (HFC), a prebiotic 0% treatment (HF+LA+sea tangle 0%, ST0), a prebiotic 5% treatment (HF+LA+sea tangle 5%, ST5), a prebiotic 10% treatment (HF+LA+sea tangle 10%, ST10), and a prebiotic 15% treatment group (HF+LA+sea tangle 15%, ST15) to conduct experiments with various levels of prebiotics. According to the results of the experiment, the NFC group showed the highest daily weight gain (22.34g) and the ST0 group showed the lowest daily weight gain (19.41g). However, weight gains during the entire experimental period were the highest in the HFC group (475.73g) and the lowest in the ST0 group (454.23g). Feed efficiency was the highest in the HFC group (0.20). Treatment with synbiotics composed of LAB and sea tangle suppressed weight increases due to HF diet and reduced feed efficiency. Intestinal microorganisms were identified through pyrosequncing and according to the results, Firmicutes phylum (approximately 60%) and Bacteroidetes phylum (approximately 30%) accounted for approximately 90% or more of intestinal microorganisms in all of the treatment groups indicating these bacteria are dominating in the intestines. Firmicutes that is related to weight increases accounted for 64.96% of microorganisms in the NFC group, 75.32% in the HFC group, 59.51% in the ST0 group, 61.29% in the ST5 group, 49.91% in the ST10 group, and 39.65% in the ST15 group. Therefore, Firmicutes showed the highest share the HFC group that showed high weight gains and the lowest share in the group treated with mixed synbiotics composed of LAB and sea tangle. Bacteroidetes that is related to weight gain inhibition accounted for 32.12% of microorganisms in the NFC group, and HFC group 21.57%, ST0 group 37.66%, ST5 group 34.92%, ST10 group 44.46%, and ST15 group 53.22%. Therefore, the share of Bacteroidetes was the lowest in the HFC group with no addition of synbiotics and increased along with the level of treatment with synbiotics. Changes in blood components were not significantly different among the groups and SCFA yields were shown to be higher in groups treated with synbiotics than in groups not added with synbiotics. Through the present study, it was shown that the supply of synbiotics composed of LAB and sea tangle increased feed intake but led to weight losses and that the intake of synbiotics composed of LAB and sea tangle had anti-obesity effects due to decreases in Firmicutes which are microorganisms related to weight gains and increases in Bacteroidetes which are microorganisms related to weight losses. Therefore, synbiotics composed of LAB and sea tangle are considered to have the effect to prevent metabolic disorders in the rat. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bacteroidetes" title="bacteroidetes">bacteroidetes</a>, <a href="https://publications.waset.org/abstracts/search?q=firmicutes" title=" firmicutes"> firmicutes</a>, <a href="https://publications.waset.org/abstracts/search?q=intestinal%20microbiota" title=" intestinal microbiota"> intestinal microbiota</a>, <a href="https://publications.waset.org/abstracts/search?q=lactic%20acid" title=" lactic acid"> lactic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=sea%20tangle" title=" sea tangle"> sea tangle</a>, <a href="https://publications.waset.org/abstracts/search?q=synbiotics" title=" synbiotics"> synbiotics</a> </p> <a href="https://publications.waset.org/abstracts/49562/effect-of-synbiotics-on-rats-intestinal-microbiota" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49562.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">400</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> 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