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Vincent Christoffels
<!DOCTYPE html> <html lang="en-US"> <head> <title>Vincent Christoffels</title> <meta http-equiv="Content-Style-Type" content="text/css" /> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="title" content="Vincent Christoffels" /> <meta name="firstname" content="Vincent" /> <meta name="lastname" content="Christoffels" /> <meta name="sortname" content="christoffels" /> <meta name="personaltitle" content="Prof. PhD" /> <meta name="organisation" content="Amsterdam UMC" /> <meta name="pi" content="true" /> <meta name="research_institute" content="Amsterdam Cardiovascular Sciences" /> <meta name="research_institute" content="Amsterdam Reproduction & Development" /> <meta name="function" content="Full Professor" /> <meta name="functionorganisation" content="Full Professor, ACS - Heart Failure & Arrhythmias" /> <meta name="functionorganisation" content="Affiliatie UvA" /> <meta name="function" content="Full Professor" /> <meta name="functionorganisation" content="Full Professor, Amsterdam Reproduction & Development (AR&D)" /> <meta name="function" content="Full Professor" /> <meta name="functionorganisation" content="Full Professor, Medical Biology" /> <meta name="leadImage" content="/upload_mm/c/a/b/cid3595_1727501558722_Christoffels3_small.jpg" /> <meta name="profilephotourl" content="https://amsco.elsevierpure.com/ws/files/82658665/Christoffels3_small.jpg" /> <meta name="publicationyears" content="{1993=1, 1994=1, 1995=2, 1996=1, 1998=3, 1999=2, 2000=5, 2001=4, 2002=2, 2003=9, 2004=7, 2005=7, 2006=4, 2007=8, 2008=8, 2009=12, 2010=11, 2011=9, 2012=13, 2013=20, 2014=19, 2015=7, 2016=15, 2017=7, 2018=9, 2019=14, 2020=19, 2021=31, 2022=16, 2023=13, 2024=4}" /> <meta name="research_program" content="ACS - Heart Failure & Arrhythmias" /> <meta name="research_interest" content="Developmental biology Heart development Transcriptional regulation Epigenetics Congenital heart defects Conduction system Sinoatrial node Arrhythmias Transgenic mice Lineage analysis" /> <meta name="specialisation" content="developmental biology, molecular biology, heart development" /> <meta name="recent_publication" content="TAD boundary deletion causes PITX2-related cardiac electrical and structural defectsBaudic, M., Murata, H., Bosada, F. M., Melo, U. S., Aizawa, T., Lindenbaum, P., van der Maarel, L. E., Guedon, A., Baron, E., Fremy, E., Foucal, A., Ishikawa, T., Ushinohama, H., Jurgens, S. J., Choi, S. H., Kyndt, F., le Scouarnec, S., Wakker, V., Thollet, A., Rajalu, A., & 24 othersTakaki, T., Ohno, S., Shimizu, W., Horie, M., Kimura, T., Ellinor, P. T., Petit, F., Dulac, Y., Bru, P., Boland, A., Deleuze, J-F., Redon, R., le Marec, H., le Tourneau, T., Gourraud, J-B., Yoshida, Y., Makita, N., Vieyres, C., Makiyama, T., Mundlos, S., Christoffels, V. M., Probst, V., Schott, J-J. & Barc, J., 1 Dec 2024, In: Nature communications. 15, 1, 3380. Research output: Contribution to journal › Article › Academic › peer-review" /> <meta name="recent_publication" content="The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and DiseaseGiovou, A. E., Gladka, M. M. & Christoffels, V. M., Jun 2024, In: Cells. 13, 11, 931. Research output: Contribution to journal › Review article › Academic › peer-review" /> <meta name="recent_publication" content="Role of Genetic Variation in Transcriptional Regulatory Elements in Heart RhythmJonker, T., Barnett, P., Boink, G. J. J. & Christoffels, V. M., 1 Jan 2024, In: Cells. 13, 1, 4. Research output: Contribution to journal › Review article › Academic › peer-review" /> <meta name="key_publication" content="EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signaturesvan Duijvenboden, K., de Boer, B. A., Capon, N., Ruijter, J. M. & Christoffels, V. M., 2016, In: Nucleic Acids Research. 44, 5, p. e42 Research output: Contribution to journal › Article › Academic › peer-review" /> <meta name="key_publication" content="GATA-dependent regulatory switches establish atrioventricular canal specificity during heart developmentStefanovic, S., Barnett, P., van Duijvenboden, K., Weber, D., Gessler, M. & Christoffels, V. M., 2014, In: Nature communications. 5, p. 3680 Research output: Contribution to journal › Article › Academic › peer-review" /> <meta name="key_publication" content="A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction systemvan Weerd, J. H., Badi, I., van den Boogaard, M., Stefanovic, S., van de Werken, H. J. G., Gomez-Velazquez, M., Badia-Careaga, C., Manzanares, M., de Laat, W., Barnett, P. & Christoffels, V. M., 2014, In: Circulation Research. 115, 4, p. 432-441 Research output: Contribution to journal › Article › Academic › peer-review" /> <meta name="versionid" content="3595" /> <meta name="targetid" content="101118" /> <meta name="title_no_special_characters" content="vincentchristoffels" /> <meta name="html_title_no_special_characters" content="vincentchristoffels" /> <meta name="titleletter" content="V" /> <meta name="publicationdate" content="2020-09-19T07:34:00Z" /> <meta name="headings" content="" /> <meta name="breadcrumbs" content="Researchers" /> <meta name="breadcrumbs" content="Research" /> <meta name="breadcrumbs" content="Amsterdam Reproduction & Development" /> <meta name="content_last_modified_date" content="2024-11-27T17:08:17Z" /> <!-- Powered by GX GX Software Nijmegen http://www.gxsoftware.com/ --> <meta name="title" content="Vincent Christoffels" /> <meta property="og:title" content="Vincent Christoffels" /> <meta name="keywords" content="Research" /> <meta 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class="main-content-header"> <!-- indexer: off --> <h2 class="title" title="Vincent Christoffels" size="large">Vincent Christoffels</h2> <!-- indexer: on --> </div> <div class="main-content"> <!-- indexer: on --> <article class="content"> <div class="researcher-metadata"> <span>Prof. PhD</span> <p> <span>Full Professor, ACS - Heart Failure & Arrhythmias</span> <span>Affiliatie UvA</span> <span>Full Professor, Amsterdam Reproduction & Development (AR&D)</span> <span>Full Professor, Medical Biology</span> </p> </div> <div class="researcher-output researcher-output--detail"> <span class="researcher-pi" aria-label="Principal Investigator">PI</span> <div class="research-output-graph" data-research-output="{"1993": 1, "1994": 1, "1995": 2, "1996": 1, "1998": 3, "1999": 2, "2000": 5, "2001": 4, "2002": 2, "2003": 9, "2004": 7, "2005": 7, "2006": 4, "2007": 8, "2008": 8, "2009": 12, "2010": 11, "2011": 9, "2012": 13, "2013": 20, "2014": 19, "2015": 7, "2016": 15, "2017": 7, "2018": 9, "2019": 14, "2020": 19, "2021": 31, "2022": 16, "2023": 13, "2024": 4}"> <span class="research-output-from"></span> <span class="research-output"></span> <span class="research-output-to"></span> </div> </div> <div class="researcher-content"> <h6>Specialization</h6> <p>developmental biology, molecular biology, heart development</p> <h6>Focus of research</h6> <ul> <li>Developmental biology</li> <li>Heart development</li> <li>Transcriptional regulation</li> <li>Epigenetics</li> <li>Congenital heart defects</li> <li>Conduction system</li> <li>Sinoatrial node</li> <li>Arrhythmias</li> <li>Transgenic mice</li> <li>Lineage analysis</li> </ul> </div> </article> <!-- indexer: off --> <aside> <div class="sidebar-wrapper"> <div class="sidebar-researcher-image"> <img src="/upload_mm/c/a/b/cid3595_1727501558722_Christoffels3_small.jpg" alt="Vincent Christoffels" /> </div> <div class="content-sidebar content-sidebar--vertical"> <div class="researcher-location"><img src="/static/researchpresentation/images/logo-amsterdamumc.svg" alt="Amsterdam UMC" /></div> <nav class="sidebar-list" aria-label="Sidebar"><p class="list-header">More information</p> <ul class="inline"> <li><a href="https://researchinformation.amsterdamumc.org/en/persons/f541bd73-a57a-4e73-92b7-2f89930ea498" target="_blank" class="link--out">Full profile</a></li> </ul> <p class="list-header">Research institutes</p> <ul> <li><a href="/en/research/institutes/amsterdam-cardiovascular-sciences.htm" class="navigation" title="Amsterdam Cardiovascular Sciences">Amsterdam Cardiovascular Sciences</a></li> <li><a href="#">Amsterdam Reproduction & Development</a></li> </ul> <p class="list-header">Research programs</p> <ul> <li><a href="/en/research/institutes/amsterdam-cardiovascular-sciences/programs/heart-failure-arrhythmias.htm" class="navigation" title="Heart Failure & Arrhythmias">Heart Failure & Arrhythmias</a></li> </ul></nav> </div> </div> </aside> </div> <div class="bottom-content bottom-content--small"> <div class="tabs"> <div class="tabs-header"> <ul role="tablist"> <li role="presentation"> <a role="tab" href="#tab-section-1" id="tab-1" aria-controls="tab-section-1" tabindex="-1">Key publications</a> </li> <li role="presentation"> <a role="tab" href="#tab-section-2" id="tab-2" aria-controls="tab-section-2" tabindex="-1">Latest publications</a> </li> </ul> </div> <div class="tabs-content"> <section role="tabpanel" id="tab-section-1" aria-labelledby="tab-1" hidden> <div class="publication-overview"> <ul class="publication-list"> <li class="publication"> <div class="rendering rendering_researchoutput rendering_researchoutput_portal-short rendering_contributiontojournal rendering_portal-short rendering_contributiontojournal_portal-short"><a target="_blank" class="link--out" href="https://researchinformation.amsterdamumc.org/en/publications/664d248d-6612-4005-80ab-f0b5eb9c7255"><h6 class="title"><span>EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures</span></h6></a><span class="person">van Duijvenboden, K.</span>, <span class="person">de Boer, B. A.</span>, <span>Capon, N.</span>, <span class="person">Ruijter, J. M.</span> & <span class="person">Christoffels, V. M.</span>, <span class="date">2016</span>, <span class="journal">In: <span>Nucleic Acids Research.</span></span> <span class="volume">44</span>, <span class="journalnumber">5</span>, <span class="pages">p. e42</span><p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Contribution to journal<span class="type_parent_sep"> › </span></span><span class="type_classification">Article</span><span class="type_classification"><span class="type_parent_sep"> › </span>Academic</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </li> <li class="publication"> <div class="rendering rendering_researchoutput rendering_researchoutput_portal-short rendering_contributiontojournal rendering_portal-short rendering_contributiontojournal_portal-short"><a target="_blank" class="link--out" href="https://researchinformation.amsterdamumc.org/en/publications/be705352-35be-4f1c-b4fa-6e73c587e173"><h6 class="title"><span>GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development</span></h6></a><span>Stefanovic, S.</span>, <span class="person">Barnett, P.</span>, <span class="person">van Duijvenboden, K.</span>, <span>Weber, D.</span>, <span>Gessler, M.</span> & <span class="person">Christoffels, V. M.</span>, <span class="date">2014</span>, <span class="journal">In: <span>Nature communications.</span></span> <span class="volume">5</span>, <span class="pages">p. 3680</span><p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Contribution to journal<span class="type_parent_sep"> › </span></span><span class="type_classification">Article</span><span class="type_classification"><span class="type_parent_sep"> › </span>Academic</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </li> <li class="publication"> <div class="rendering rendering_researchoutput rendering_researchoutput_portal-short rendering_contributiontojournal rendering_portal-short rendering_contributiontojournal_portal-short"><a target="_blank" class="link--out" href="https://researchinformation.amsterdamumc.org/en/publications/39467448-d0cf-49c6-8220-6b39d592ac6b"><h6 class="title"><span>A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system</span></h6></a><span class="person">van Weerd, J. H.</span>, <span>Badi, I.</span>, <span class="person">van den Boogaard, M.</span>, <span>Stefanovic, S.</span>, <span>van de Werken, H. J. G.</span>, <span>Gomez-Velazquez, M.</span>, <span>Badia-Careaga, C.</span>, <span>Manzanares, M.</span>, <span>de Laat, W.</span>, <span class="person">Barnett, P.</span> & <span class="person">Christoffels, V. M.</span>, <span class="date">2014</span>, <span class="journal">In: <span>Circulation Research.</span></span> <span class="volume">115</span>, <span class="journalnumber">4</span>, <span class="pages">p. 432-441</span><p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Contribution to journal<span class="type_parent_sep"> › </span></span><span class="type_classification">Article</span><span class="type_classification"><span class="type_parent_sep"> › </span>Academic</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </li> <li class="all-publications"> <a href="https://researchinformation.amsterdamumc.org/en/persons/f541bd73-a57a-4e73-92b7-2f89930ea498" class="link--out">All publications</a> </li> </ul> </div> </section> <section role="tabpanel" id="tab-section-2" aria-labelledby="tab-2" hidden> <div class="publication-overview"> <ul class="publication-list"> <li class="publication"> <div class="rendering rendering_researchoutput rendering_researchoutput_portal-short rendering_contributiontojournal rendering_portal-short rendering_contributiontojournal_portal-short"><a target="_blank" class="link--out" href="https://researchinformation.amsterdamumc.org/en/publications/a3fcf0cf-a95d-4134-934a-e96e6bb1ba04"><h6 class="title"><span>TAD boundary deletion causes PITX2-related cardiac electrical and structural defects</span></h6></a>Baudic, M., Murata, H., <span>Bosada, F. M.</span>, Melo, U. S., Aizawa, T., Lindenbaum, P., <span>van der Maarel, L. E.</span>, Guedon, A., Baron, E., Fremy, E., Foucal, A., Ishikawa, T., Ushinohama, H., <span>Jurgens, S. J.</span>, Choi, S. H., Kyndt, F., le Scouarnec, S., <span>Wakker, V.</span>, Thollet, A., Rajalu, A., <a onclick="$(this).next('span').toggleClassName('common_hidden');$(this).addClassName('common_hidden'); return pure.stopEvent(event);" href="#" class="link"><span> & 24 others</span></a><span class="common_hidden publication_authors_full_inline_list"><span>Takaki, T.</span>, <span>Ohno, S.</span>, <span>Shimizu, W.</span>, <span>Horie, M.</span>, <span>Kimura, T.</span>, <span>Ellinor, P. T.</span>, <span>Petit, F.</span>, <span>Dulac, Y.</span>, <span>Bru, P.</span>, <span>Boland, A.</span>, <span>Deleuze, J-F.</span>, <span>Redon, R.</span>, <span>le Marec, H.</span>, <span>le Tourneau, T.</span>, <span>Gourraud, J-B.</span>, <span>Yoshida, Y.</span>, <span>Makita, N.</span>, <span>Vieyres, C.</span>, <span>Makiyama, T.</span>, <span>Mundlos, S.</span>, <span class="person">Christoffels, V. M.</span>, <span>Probst, V.</span>, <span>Schott, J-J.</span> & <span class="person">Barc, J.</span></span>, <span class="date">1 Dec 2024</span>, <span class="journal">In: <span>Nature communications.</span></span> <span class="volume">15</span>, <span class="journalnumber">1</span>, 3380.<p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Contribution to journal<span class="type_parent_sep"> › </span></span><span class="type_classification">Article</span><span class="type_classification"><span class="type_parent_sep"> › </span>Academic</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </li> <li class="publication"> <div class="rendering rendering_researchoutput rendering_researchoutput_portal-short rendering_contributiontojournal rendering_portal-short rendering_contributiontojournal_portal-short"><a target="_blank" class="link--out" href="https://researchinformation.amsterdamumc.org/en/publications/5f8da303-6942-4a43-b374-3115859ebd01"><h6 class="title"><span>The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease</span></h6></a><span class="person">Giovou, A. E.</span>, <span class="person">Gladka, M. M.</span> & <span class="person">Christoffels, V. M.</span>, <span class="date">Jun 2024</span>, <span class="journal">In: <span>Cells.</span></span> <span class="volume">13</span>, <span class="journalnumber">11</span>, 931.<p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Contribution to journal<span class="type_parent_sep"> › </span></span><span class="type_classification">Review article</span><span class="type_classification"><span class="type_parent_sep"> › </span>Academic</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </li> <li class="publication"> <div class="rendering rendering_researchoutput rendering_researchoutput_portal-short rendering_contributiontojournal rendering_portal-short rendering_contributiontojournal_portal-short"><a target="_blank" class="link--out" href="https://researchinformation.amsterdamumc.org/en/publications/928d1b68-83a8-4f1b-a9d7-8e6007b2a484"><h6 class="title"><span>Role of Genetic Variation in Transcriptional Regulatory Elements in Heart Rhythm</span></h6></a><span class="person">Jonker, T.</span>, <span class="person">Barnett, P.</span>, <span class="person">Boink, G. J. J.</span> & <span class="person">Christoffels, V. M.</span>, <span class="date">1 Jan 2024</span>, <span class="journal">In: <span>Cells.</span></span> <span class="volume">13</span>, <span class="journalnumber">1</span>, 4.<p class="type"><span class="type_family">Research output<span class="type_family_sep">: </span></span><span class="type_classification_parent">Contribution to journal<span class="type_parent_sep"> › </span></span><span class="type_classification">Review article</span><span class="type_classification"><span class="type_parent_sep"> › </span>Academic</span><span class="type_classification"><span class="type_parent_sep"> › </span>peer-review</span></p></div> </li> <li class="all-publications"> <a href="https://researchinformation.amsterdamumc.org/en/persons/f541bd73-a57a-4e73-92b7-2f89930ea498" class="link--out">All publications</a> </li> </ul> </div> </section> </div> </div> </div> </div> </div> <div class="back-to-top back-to-top--hide" id="back-to-top"> <button>Back to top</button> </div> </main> <footer> <div 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