Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study | The Journal of Clinical Endocrinology & Metabolism

<!DOCTYPE html> <html lang="en" class="no-js"> <head>  <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <title>Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic</title> <script type='text/javascript' defer src='//js.trendmd.com/trendmd.min.js' data-trendmdconfig='{"element":"#trendmd-suggestions"}' class='optanon-category-C0002'></script> <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.7.1/jquery.min.js" type="text/javascript"></script> <script>window.jQuery || document.write('<script src="//oup.silverchair-cdn.com/Themes/Silver/app/js/jquery.3.7.1.min.js" type="text/javascript">\x3C/script>')</script> <script src="//oup.silverchair-cdn.com/Themes/Silver/app/vendor/v-638654880267142888/jquery-migrate-1.4.1.min.js" type="text/javascript"></script> <script type='text/javascript' src='https://platform-api.sharethis.com/js/sharethis.js#property=643701de45aa460012e1032e&product=sop' async='async' class='optanon-category-C0004'></script> <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=10" /> <meta http-equiv="X-UA-Compatible" content="IE=Edge" /><script type="text/javascript">window.NREUM||(NREUM={});NREUM.info = {"beacon":"bam.nr-data.net","errorBeacon":"bam.nr-data.net","licenseKey":"8d76ca6f26","applicationID":"220513093","transactionName":"ZQBRMkVUCEtRVkINXlxKfjB0GiltYGVXA1RxCl0SRVoKVFVHGSVDRgxQClI=","queueTime":0,"applicationTime":1081,"agent":"","atts":""}</script><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]}};(window.NREUM||(NREUM={})).loader_config={xpid:"XAYBV15WGwECVFRTBAEOVQ==",licenseKey:"8d76ca6f26",applicationID:"220513093"};window.NREUM||(NREUM={}),__nr_require=function(t,e,n){function r(n){if(!e[n]){var i=e[n]={exports:{}};t[n][0].call(i.exports,function(e){var i=t[n][1][e];return r(i||e)},i,i.exports)}return e[n].exports}if("function"==typeof __nr_require)return __nr_require;for(var i=0;i<n.length;i++)r(n[i]);return r}({1:[function(t,e,n){function r(t){try{s.console&&console.log(t)}catch(e){}}var i,o=t("ee"),a=t(27),s={};try{i=localStorage.getItem("__nr_flags").split(","),console&&"function"==typeof console.log&&(s.console=!0,i.indexOf("dev")!==-1&&(s.dev=!0),i.indexOf("nr_dev")!==-1&&(s.nrDev=!0))}catch(c){}s.nrDev&&o.on("internal-error",function(t){r(t.stack)}),s.dev&&o.on("fn-err",function(t,e,n){r(n.stack)}),s.dev&&(r("NR AGENT IN DEVELOPMENT MODE"),r("flags: "+a(s,function(t,e){return t}).join(", ")))},{}],2:[function(t,e,n){function r(t,e,n,r,s){try{p?p-=1:i(s||new UncaughtException(t,e,n),!0)}catch(f){try{o("ierr",[f,c.now(),!0])}catch(d){}}return"function"==typeof u&&u.apply(this,a(arguments))}function UncaughtException(t,e,n){this.message=t||"Uncaught error with no additional information",this.sourceURL=e,this.line=n}function i(t,e){var n=e?null:c.now();o("err",[t,n])}var o=t("handle"),a=t(28),s=t("ee"),c=t("loader"),f=t("gos"),u=window.onerror,d=!1,l="nr@seenError";if(!c.disabled){var p=0;c.features.err=!0,t(1),window.onerror=r;try{throw new Error}catch(h){"stack"in h&&(t(10),t(9),"addEventListener"in window&&t(6),c.xhrWrappable&&t(11),d=!0)}s.on("fn-start",function(t,e,n){d&&(p+=1)}),s.on("fn-err",function(t,e,n){d&&!n[l]&&(f(n,l,function(){return!0}),this.thrown=!0,i(n))}),s.on("fn-end",function(){d&&!this.thrown&&p>0&&(p-=1)}),s.on("internal-error",function(t){o("ierr",[t,c.now(),!0])})}},{}],3:[function(t,e,n){var r=t("loader");r.disabled||(r.features.ins=!0)},{}],4:[function(t,e,n){function r(){var t=new PerformanceObserver(function(t,e){var n=t.getEntries();s(v,[n])});try{t.observe({entryTypes:["resource"]})}catch(e){}}function i(t){if(s(v,[window.performance.getEntriesByType(w)]),window.performance["c"+l])try{window.performance[h](m,i,!1)}catch(t){}else try{window.performance[h]("webkit"+m,i,!1)}catch(t){}}function o(t){}if(window.performance&&window.performance.timing&&window.performance.getEntriesByType){var a=t("ee"),s=t("handle"),c=t(10),f=t(9),u=t(5),d=t(19),l="learResourceTimings",p="addEventListener",h="removeEventListener",m="resourcetimingbufferfull",v="bstResource",w="resource",g="-start",y="-end",x="fn"+g,b="fn"+y,E="bstTimer",R="pushState",S=t("loader");if(!S.disabled){S.features.stn=!0,t(8),"addEventListener"in window&&t(6);var O=NREUM.o.EV;a.on(x,function(t,e){var n=t[0];n instanceof O&&(this.bstStart=S.now())}),a.on(b,function(t,e){var n=t[0];n instanceof O&&s("bst",[n,e,this.bstStart,S.now()])}),c.on(x,function(t,e,n){this.bstStart=S.now(),this.bstType=n}),c.on(b,function(t,e){s(E,[e,this.bstStart,S.now(),this.bstType])}),f.on(x,function(){this.bstStart=S.now()}),f.on(b,function(t,e){s(E,[e,this.bstStart,S.now(),"requestAnimationFrame"])}),a.on(R+g,function(t){this.time=S.now(),this.startPath=location.pathname+location.hash}),a.on(R+y,function(t){s("bstHist",[location.pathname+location.hash,this.startPath,this.time])}),u()?(s(v,[window.performance.getEntriesByType("resource")]),r()):p in window.performance&&(window.performance["c"+l]?window.performance[p](m,i,d(!1)):window.performance[p]("webkit"+m,i,d(!1))),document[p]("scroll",o,d(!1)),document[p]("keypress",o,d(!1)),document[p]("click",o,d(!1))}}},{}],5:[function(t,e,n){e.exports=function(){return"PerformanceObserver"in window&&"function"==typeof window.PerformanceObserver}},{}],6:[function(t,e,n){function r(t){for(var e=t;e&&!e.hasOwnProperty(u);)e=Object.getPrototypeOf(e);e&&i(e)}function i(t){s.inPlace(t,[u,d],"-",o)}function o(t,e){return t[1]}var a=t("ee").get("events"),s=t("wrap-function")(a,!0),c=t("gos"),f=XMLHttpRequest,u="addEventListener",d="removeEventListener";e.exports=a,"getPrototypeOf"in Object?(r(document),r(window),r(f.prototype)):f.prototype.hasOwnProperty(u)&&(i(window),i(f.prototype)),a.on(u+"-start",function(t,e){var n=t[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var r=c(n,"nr@wrapped",function(){function t(){if("function"==typeof n.handleEvent)return n.handleEvent.apply(n,arguments)}var e={object:t,"function":n}[typeof n];return e?s(e,"fn-",null,e.name||"anonymous"):n});this.wrapped=t[1]=r}}),a.on(d+"-start",function(t){t[1]=this.wrapped||t[1]})},{}],7:[function(t,e,n){function r(t,e,n){var r=t[e];"function"==typeof r&&(t[e]=function(){var t=o(arguments),e={};i.emit(n+"before-start",[t],e);var a;e[m]&&e[m].dt&&(a=e[m].dt);var s=r.apply(this,t);return i.emit(n+"start",[t,a],s),s.then(function(t){return i.emit(n+"end",[null,t],s),t},function(t){throw i.emit(n+"end",[t],s),t})})}var i=t("ee").get("fetch"),o=t(28),a=t(27);e.exports=i;var s=window,c="fetch-",f=c+"body-",u=["arrayBuffer","blob","json","text","formData"],d=s.Request,l=s.Response,p=s.fetch,h="prototype",m="nr@context";d&&l&&p&&(a(u,function(t,e){r(d[h],e,f),r(l[h],e,f)}),r(s,"fetch",c),i.on(c+"end",function(t,e){var n=this;if(e){var r=e.headers.get("content-length");null!==r&&(n.rxSize=r),i.emit(c+"done",[null,e],n)}else i.emit(c+"done",[t],n)}))},{}],8:[function(t,e,n){var r=t("ee").get("history"),i=t("wrap-function")(r);e.exports=r;var o=window.history&&window.history.constructor&&window.history.constructor.prototype,a=window.history;o&&o.pushState&&o.replaceState&&(a=o),i.inPlace(a,["pushState","replaceState"],"-")},{}],9:[function(t,e,n){var r=t("ee").get("raf"),i=t("wrap-function")(r),o="equestAnimationFrame";e.exports=r,i.inPlace(window,["r"+o,"mozR"+o,"webkitR"+o,"msR"+o],"raf-"),r.on("raf-start",function(t){t[0]=i(t[0],"fn-")})},{}],10:[function(t,e,n){function r(t,e,n){t[0]=a(t[0],"fn-",null,n)}function i(t,e,n){this.method=n,this.timerDuration=isNaN(t[1])?0:+t[1],t[0]=a(t[0],"fn-",this,n)}var o=t("ee").get("timer"),a=t("wrap-function")(o),s="setTimeout",c="setInterval",f="clearTimeout",u="-start",d="-";e.exports=o,a.inPlace(window,[s,"setImmediate"],s+d),a.inPlace(window,[c],c+d),a.inPlace(window,[f,"clearImmediate"],f+d),o.on(c+u,r),o.on(s+u,i)},{}],11:[function(t,e,n){function r(t,e){d.inPlace(e,["onreadystatechange"],"fn-",s)}function i(){var t=this,e=u.context(t);t.readyState>3&&!e.resolved&&(e.resolved=!0,u.emit("xhr-resolved",[],t)),d.inPlace(t,y,"fn-",s)}function o(t){x.push(t),m&&(E?E.then(a):w?w(a):(R=-R,S.data=R))}function a(){for(var t=0;t<x.length;t++)r([],x[t]);x.length&&(x=[])}function s(t,e){return e}function c(t,e){for(var n in t)e[n]=t[n];return e}t(6);var f=t("ee"),u=f.get("xhr"),d=t("wrap-function")(u),l=t(19),p=NREUM.o,h=p.XHR,m=p.MO,v=p.PR,w=p.SI,g="readystatechange",y=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],x=[];e.exports=u;var b=window.XMLHttpRequest=function(t){var e=new h(t);try{u.emit("new-xhr",[e],e),e.addEventListener(g,i,l(!1))}catch(n){try{u.emit("internal-error",[n])}catch(r){}}return e};if(c(h,b),b.prototype=h.prototype,d.inPlace(b.prototype,["open","send"],"-xhr-",s),u.on("send-xhr-start",function(t,e){r(t,e),o(e)}),u.on("open-xhr-start",r),m){var E=v&&v.resolve();if(!w&&!v){var R=1,S=document.createTextNode(R);new m(a).observe(S,{characterData:!0})}}else f.on("fn-end",function(t){t[0]&&t[0].type===g||a()})},{}],12:[function(t,e,n){function r(t){if(!s(t))return null;var e=window.NREUM;if(!e.loader_config)return null;var n=(e.loader_config.accountID||"").toString()||null,r=(e.loader_config.agentID||"").toString()||null,f=(e.loader_config.trustKey||"").toString()||null;if(!n||!r)return null;var h=p.generateSpanId(),m=p.generateTraceId(),v=Date.now(),w={spanId:h,traceId:m,timestamp:v};return(t.sameOrigin||c(t)&&l())&&(w.traceContextParentHeader=i(h,m),w.traceContextStateHeader=o(h,v,n,r,f)),(t.sameOrigin&&!u()||!t.sameOrigin&&c(t)&&d())&&(w.newrelicHeader=a(h,m,v,n,r,f)),w}function i(t,e){return"00-"+e+"-"+t+"-01"}function o(t,e,n,r,i){var o=0,a="",s=1,c="",f="";return i+"@nr="+o+"-"+s+"-"+n+"-"+r+"-"+t+"-"+a+"-"+c+"-"+f+"-"+e}function a(t,e,n,r,i,o){var a="btoa"in window&&"function"==typeof window.btoa;if(!a)return null;var s={v:[0,1],d:{ty:"Browser",ac:r,ap:i,id:t,tr:e,ti:n}};return o&&r!==o&&(s.d.tk=o),btoa(JSON.stringify(s))}function s(t){return f()&&c(t)}function c(t){var e=!1,n={};if("init"in NREUM&&"distributed_tracing"in NREUM.init&&(n=NREUM.init.distributed_tracing),t.sameOrigin)e=!0;else if(n.allowed_origins instanceof Array)for(var r=0;r<n.allowed_origins.length;r++){var i=h(n.allowed_origins[r]);if(t.hostname===i.hostname&&t.protocol===i.protocol&&t.port===i.port){e=!0;break}}return e}function f(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.enabled}function u(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.exclude_newrelic_header}function d(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&NREUM.init.distributed_tracing.cors_use_newrelic_header!==!1}function l(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.cors_use_tracecontext_headers}var p=t(24),h=t(14);e.exports={generateTracePayload:r,shouldGenerateTrace:s}},{}],13:[function(t,e,n){function r(t){var e=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(var r=0;r<l;r++)t.removeEventListener(d[r],this.listener,!1);return e.protocol&&"data"===e.protocol?void g("Ajax/DataUrl/Excluded"):void(e.aborted||(n.duration=a.now()-this.startTime,this.loadCaptureCalled||4!==t.readyState?null==e.status&&(e.status=0):o(this,t),n.cbTime=this.cbTime,s("xhr",[e,n,this.startTime,this.endTime,"xhr"],this)))}}function i(t,e){var n=c(e),r=t.params;r.hostname=n.hostname,r.port=n.port,r.protocol=n.protocol,r.host=n.hostname+":"+n.port,r.pathname=n.pathname,t.parsedOrigin=n,t.sameOrigin=n.sameOrigin}function o(t,e){t.params.status=e.status;var n=v(e,t.lastSize);if(n&&(t.metrics.rxSize=n),t.sameOrigin){var r=e.getResponseHeader("X-NewRelic-App-Data");r&&(t.params.cat=r.split(", ").pop())}t.loadCaptureCalled=!0}var a=t("loader");if(a.xhrWrappable&&!a.disabled){var s=t("handle"),c=t(14),f=t(12).generateTracePayload,u=t("ee"),d=["load","error","abort","timeout"],l=d.length,p=t("id"),h=t(20),m=t(18),v=t(15),w=t(19),g=t(21).recordSupportability,y=NREUM.o.REQ,x=window.XMLHttpRequest;a.features.xhr=!0,t(11),t(7),u.on("new-xhr",function(t){var e=this;e.totalCbs=0,e.called=0,e.cbTime=0,e.end=r,e.ended=!1,e.xhrGuids={},e.lastSize=null,e.loadCaptureCalled=!1,e.params=this.params||{},e.metrics=this.metrics||{},t.addEventListener("load",function(n){o(e,t)},w(!1)),h&&(h>34||h<10)||t.addEventListener("progress",function(t){e.lastSize=t.loaded},w(!1))}),u.on("open-xhr-start",function(t){this.params={method:t[0]},i(this,t[1]),this.metrics={}}),u.on("open-xhr-end",function(t,e){"loader_config"in NREUM&&"xpid"in NREUM.loader_config&&this.sameOrigin&&e.setRequestHeader("X-NewRelic-ID",NREUM.loader_config.xpid);var n=f(this.parsedOrigin);if(n){var r=!1;n.newrelicHeader&&(e.setRequestHeader("newrelic",n.newrelicHeader),r=!0),n.traceContextParentHeader&&(e.setRequestHeader("traceparent",n.traceContextParentHeader),n.traceContextStateHeader&&e.setRequestHeader("tracestate",n.traceContextStateHeader),r=!0),r&&(this.dt=n)}}),u.on("send-xhr-start",function(t,e){var n=this.metrics,r=t[0],i=this;if(n&&r){var o=m(r);o&&(n.txSize=o)}this.startTime=a.now(),this.listener=function(t){try{"abort"!==t.type||i.loadCaptureCalled||(i.params.aborted=!0),("load"!==t.type||i.called===i.totalCbs&&(i.onloadCalled||"function"!=typeof e.onload))&&i.end(e)}catch(n){try{u.emit("internal-error",[n])}catch(r){}}};for(var s=0;s<l;s++)e.addEventListener(d[s],this.listener,w(!1))}),u.on("xhr-cb-time",function(t,e,n){this.cbTime+=t,e?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof n.onload||this.end(n)}),u.on("xhr-load-added",function(t,e){var n=""+p(t)+!!e;this.xhrGuids&&!this.xhrGuids[n]&&(this.xhrGuids[n]=!0,this.totalCbs+=1)}),u.on("xhr-load-removed",function(t,e){var n=""+p(t)+!!e;this.xhrGuids&&this.xhrGuids[n]&&(delete this.xhrGuids[n],this.totalCbs-=1)}),u.on("xhr-resolved",function(){this.endTime=a.now()}),u.on("addEventListener-end",function(t,e){e instanceof x&&"load"===t[0]&&u.emit("xhr-load-added",[t[1],t[2]],e)}),u.on("removeEventListener-end",function(t,e){e instanceof x&&"load"===t[0]&&u.emit("xhr-load-removed",[t[1],t[2]],e)}),u.on("fn-start",function(t,e,n){e instanceof x&&("onload"===n&&(this.onload=!0),("load"===(t[0]&&t[0].type)||this.onload)&&(this.xhrCbStart=a.now()))}),u.on("fn-end",function(t,e){this.xhrCbStart&&u.emit("xhr-cb-time",[a.now()-this.xhrCbStart,this.onload,e],e)}),u.on("fetch-before-start",function(t){function e(t,e){var n=!1;return e.newrelicHeader&&(t.set("newrelic",e.newrelicHeader),n=!0),e.traceContextParentHeader&&(t.set("traceparent",e.traceContextParentHeader),e.traceContextStateHeader&&t.set("tracestate",e.traceContextStateHeader),n=!0),n}var n,r=t[1]||{};"string"==typeof t[0]?n=t[0]:t[0]&&t[0].url?n=t[0].url:window.URL&&t[0]&&t[0]instanceof URL&&(n=t[0].href),n&&(this.parsedOrigin=c(n),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=f(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if("string"==typeof t[0]||window.URL&&t[0]&&t[0]instanceof URL){var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),e(o.headers,i)&&(this.dt=i),t.length>1?t[1]=o:t.push(o)}else t[0]&&t[0].headers&&e(t[0].headers,i)&&(this.dt=i)}),u.on("fetch-start",function(t,e){this.params={},this.metrics={},this.startTime=a.now(),this.dt=e,t.length>=1&&(this.target=t[0]),t.length>=2&&(this.opts=t[1]);var n,r=this.opts||{},o=this.target;if("string"==typeof o?n=o:"object"==typeof o&&o instanceof y?n=o.url:window.URL&&"object"==typeof o&&o instanceof URL&&(n=o.href),i(this,n),"data"!==this.params.protocol){var s=(""+(o&&o instanceof y&&o.method||r.method||"GET")).toUpperCase();this.params.method=s,this.txSize=m(r.body)||0}}),u.on("fetch-done",function(t,e){if(this.endTime=a.now(),this.params||(this.params={}),"data"===this.params.protocol)return void g("Ajax/DataUrl/Excluded");this.params.status=e?e.status:0;var n;"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);var r={txSize:this.txSize,rxSize:n,duration:a.now()-this.startTime};s("xhr",[this.params,r,this.startTime,this.endTime,"fetch"],this)})}},{}],14:[function(t,e,n){var r={};e.exports=function(t){if(t in r)return r[t];if(0===(t||"").indexOf("data:"))return{protocol:"data"};var e=document.createElement("a"),n=window.location,i={};e.href=t,i.port=e.port;var o=e.href.split("://");!i.port&&o[1]&&(i.port=o[1].split("/")[0].split("@").pop().split(":")[1]),i.port&&"0"!==i.port||(i.port="https"===o[0]?"443":"80"),i.hostname=e.hostname||n.hostname,i.pathname=e.pathname,i.protocol=o[0],"/"!==i.pathname.charAt(0)&&(i.pathname="/"+i.pathname);var a=!e.protocol||":"===e.protocol||e.protocol===n.protocol,s=e.hostname===document.domain&&e.port===n.port;return i.sameOrigin=a&&(!e.hostname||s),"/"===i.pathname&&(r[t]=i),i}},{}],15:[function(t,e,n){function r(t,e){var n=t.responseType;return"json"===n&&null!==e?e:"arraybuffer"===n||"blob"===n||"json"===n?i(t.response):"text"===n||""===n||void 0===n?i(t.responseText):void 0}var i=t(18);e.exports=r},{}],16:[function(t,e,n){function r(){}function i(t,e,n,r){return function(){return u.recordSupportability("API/"+e+"/called"),o(t+e,[f.now()].concat(s(arguments)),n?null:this,r),n?void 0:this}}var o=t("handle"),a=t(27),s=t(28),c=t("ee").get("tracer"),f=t("loader"),u=t(21),d=NREUM;"undefined"==typeof window.newrelic&&(newrelic=d);var l=["setPageViewName","setCustomAttribute","setErrorHandler","finished","addToTrace","inlineHit","addRelease"],p="api-",h=p+"ixn-";a(l,function(t,e){d[e]=i(p,e,!0,"api")}),d.addPageAction=i(p,"addPageAction",!0),d.setCurrentRouteName=i(p,"routeName",!0),e.exports=newrelic,d.interaction=function(){return(new r).get()};var m=r.prototype={createTracer:function(t,e){var n={},r=this,i="function"==typeof e;return o(h+"tracer",[f.now(),t,n],r),function(){if(c.emit((i?"":"no-")+"fn-start",[f.now(),r,i],n),i)try{return e.apply(this,arguments)}catch(t){throw c.emit("fn-err",[arguments,this,t],n),t}finally{c.emit("fn-end",[f.now()],n)}}}};a("actionText,setName,setAttribute,save,ignore,onEnd,getContext,end,get".split(","),function(t,e){m[e]=i(h,e)}),newrelic.noticeError=function(t,e){"string"==typeof t&&(t=new Error(t)),u.recordSupportability("API/noticeError/called"),o("err",[t,f.now(),!1,e])}},{}],17:[function(t,e,n){function r(t){if(NREUM.init){for(var e=NREUM.init,n=t.split("."),r=0;r<n.length-1;r++)if(e=e[n[r]],"object"!=typeof e)return;return e=e[n[n.length-1]]}}e.exports={getConfiguration:r}},{}],18:[function(t,e,n){e.exports=function(t){if("string"==typeof t&&t.length)return t.length;if("object"==typeof t){if("undefined"!=typeof ArrayBuffer&&t instanceof ArrayBuffer&&t.byteLength)return t.byteLength;if("undefined"!=typeof Blob&&t instanceof Blob&&t.size)return t.size;if(!("undefined"!=typeof FormData&&t instanceof FormData))try{return JSON.stringify(t).length}catch(e){return}}}},{}],19:[function(t,e,n){var r=!1;try{var i=Object.defineProperty({},"passive",{get:function(){r=!0}});window.addEventListener("testPassive",null,i),window.removeEventListener("testPassive",null,i)}catch(o){}e.exports=function(t){return r?{passive:!0,capture:!!t}:!!t}},{}],20:[function(t,e,n){var r=0,i=navigator.userAgent.match(/Firefox[\/\s](\d+\.\d+)/);i&&(r=+i[1]),e.exports=r},{}],21:[function(t,e,n){function r(t,e){var n=[a,t,{name:t},e];return o("storeMetric",n,null,"api"),n}function i(t,e){var n=[s,t,{name:t},e];return o("storeEventMetrics",n,null,"api"),n}var o=t("handle"),a="sm",s="cm";e.exports={constants:{SUPPORTABILITY_METRIC:a,CUSTOM_METRIC:s},recordSupportability:r,recordCustom:i}},{}],22:[function(t,e,n){function r(){return s.exists&&performance.now?Math.round(performance.now()):(o=Math.max((new Date).getTime(),o))-a}function i(){return o}var o=(new Date).getTime(),a=o,s=t(29);e.exports=r,e.exports.offset=a,e.exports.getLastTimestamp=i},{}],23:[function(t,e,n){function r(t,e){var n=t.getEntries();n.forEach(function(t){"first-paint"===t.name?p("timing",["fp",Math.floor(t.startTime)]):"first-contentful-paint"===t.name&&p("timing",["fcp",Math.floor(t.startTime)])})}function i(t,e){var n=t.getEntries();if(n.length>0){var r=n[n.length-1];if(f&&f<r.startTime)return;var i=[r],o=a({});o&&i.push(o),p("lcp",i)}}function o(t){t.getEntries().forEach(function(t){t.hadRecentInput||p("cls",[t])})}function a(t){var e=navigator.connection||navigator.mozConnection||navigator.webkitConnection;if(e)return e.type&&(t["net-type"]=e.type),e.effectiveType&&(t["net-etype"]=e.effectiveType),e.rtt&&(t["net-rtt"]=e.rtt),e.downlink&&(t["net-dlink"]=e.downlink),t}function s(t){if(t instanceof w&&!y){var e=Math.round(t.timeStamp),n={type:t.type};a(n),e<=h.now()?n.fid=h.now()-e:e>h.offset&&e<=Date.now()?(e-=h.offset,n.fid=h.now()-e):e=h.now(),y=!0,p("timing",["fi",e,n])}}function c(t){"hidden"===t&&(f=h.now(),p("pageHide",[f]))}if(!("init"in NREUM&&"page_view_timing"in NREUM.init&&"enabled"in NREUM.init.page_view_timing&&NREUM.init.page_view_timing.enabled===!1)){var f,u,d,l,p=t("handle"),h=t("loader"),m=t(26),v=t(19),w=NREUM.o.EV;if("PerformanceObserver"in window&&"function"==typeof window.PerformanceObserver){u=new PerformanceObserver(r);try{u.observe({entryTypes:["paint"]})}catch(g){}d=new PerformanceObserver(i);try{d.observe({entryTypes:["largest-contentful-paint"]})}catch(g){}l=new PerformanceObserver(o);try{l.observe({type:"layout-shift",buffered:!0})}catch(g){}}if("addEventListener"in document){var y=!1,x=["click","keydown","mousedown","pointerdown","touchstart"];x.forEach(function(t){document.addEventListener(t,s,v(!1))})}m(c)}},{}],24:[function(t,e,n){function r(){function t(){return e?15&e[n++]:16*Math.random()|0}var e=null,n=0,r=window.crypto||window.msCrypto;r&&r.getRandomValues&&(e=r.getRandomValues(new Uint8Array(31)));for(var i,o="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx",a="",s=0;s<o.length;s++)i=o[s],"x"===i?a+=t().toString(16):"y"===i?(i=3&t()|8,a+=i.toString(16)):a+=i;return a}function i(){return a(16)}function o(){return a(32)}function a(t){function e(){return n?15&n[r++]:16*Math.random()|0}var n=null,r=0,i=window.crypto||window.msCrypto;i&&i.getRandomValues&&Uint8Array&&(n=i.getRandomValues(new Uint8Array(t)));for(var o=[],a=0;a<t;a++)o.push(e().toString(16));return o.join("")}e.exports={generateUuid:r,generateSpanId:i,generateTraceId:o}},{}],25:[function(t,e,n){function r(t,e){if(!i)return!1;if(t!==i)return!1;if(!e)return!0;if(!o)return!1;for(var n=o.split("."),r=e.split("."),a=0;a<r.length;a++)if(r[a]!==n[a])return!1;return!0}var i=null,o=null,a=/Version\/(\S+)\s+Safari/;if(navigator.userAgent){var s=navigator.userAgent,c=s.match(a);c&&s.indexOf("Chrome")===-1&&s.indexOf("Chromium")===-1&&(i="Safari",o=c[1])}e.exports={agent:i,version:o,match:r}},{}],26:[function(t,e,n){function r(t){function e(){t(s&&document[s]?document[s]:document[o]?"hidden":"visible")}"addEventListener"in document&&a&&document.addEventListener(a,e,i(!1))}var i=t(19);e.exports=r;var o,a,s;"undefined"!=typeof document.hidden?(o="hidden",a="visibilitychange",s="visibilityState"):"undefined"!=typeof document.msHidden?(o="msHidden",a="msvisibilitychange"):"undefined"!=typeof document.webkitHidden&&(o="webkitHidden",a="webkitvisibilitychange",s="webkitVisibilityState")},{}],27:[function(t,e,n){function r(t,e){var n=[],r="",o=0;for(r in t)i.call(t,r)&&(n[o]=e(r,t[r]),o+=1);return n}var i=Object.prototype.hasOwnProperty;e.exports=r},{}],28:[function(t,e,n){function r(t,e,n){e||(e=0),"undefined"==typeof n&&(n=t?t.length:0);for(var r=-1,i=n-e||0,o=Array(i<0?0:i);++r<i;)o[r]=t[e+r];return o}e.exports=r},{}],29:[function(t,e,n){e.exports={exists:"undefined"!=typeof window.performance&&window.performance.timing&&"undefined"!=typeof window.performance.timing.navigationStart}},{}],ee:[function(t,e,n){function r(){}function i(t){function e(t){return t&&t instanceof r?t:t?f(t,c,a):a()}function n(n,r,i,o,a){if(a!==!1&&(a=!0),!p.aborted||o){t&&a&&t(n,r,i);for(var s=e(i),c=m(n),f=c.length,u=0;u<f;u++)c[u].apply(s,r);var l=d[y[n]];return l&&l.push([x,n,r,s]),s}}function o(t,e){g[t]=m(t).concat(e)}function h(t,e){var n=g[t];if(n)for(var r=0;r<n.length;r++)n[r]===e&&n.splice(r,1)}function m(t){return g[t]||[]}function v(t){return l[t]=l[t]||i(n)}function w(t,e){p.aborted||u(t,function(t,n){e=e||"feature",y[n]=e,e in d||(d[e]=[])})}var g={},y={},x={on:o,addEventListener:o,removeEventListener:h,emit:n,get:v,listeners:m,context:e,buffer:w,abort:s,aborted:!1};return x}function o(t){return f(t,c,a)}function a(){return new r}function s(){(d.api||d.feature)&&(p.aborted=!0,d=p.backlog={})}var c="nr@context",f=t("gos"),u=t(27),d={},l={},p=e.exports=i();e.exports.getOrSetContext=o,p.backlog=d},{}],gos:[function(t,e,n){function r(t,e,n){if(i.call(t,e))return t[e];var r=n();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(t,e,{value:r,writable:!0,enumerable:!1}),r}catch(o){}return t[e]=r,r}var i=Object.prototype.hasOwnProperty;e.exports=r},{}],handle:[function(t,e,n){function r(t,e,n,r){i.buffer([t],r),i.emit(t,e,n)}var i=t("ee").get("handle");e.exports=r,r.ee=i},{}],id:[function(t,e,n){function r(t){var e=typeof t;return!t||"object"!==e&&"function"!==e?-1:t===window?0:a(t,o,function(){return i++})}var i=1,o="nr@id",a=t("gos");e.exports=r},{}],loader:[function(t,e,n){function r(){if(!O++){var t=S.info=NREUM.info,e=m.getElementsByTagName("script")[0];if(setTimeout(f.abort,3e4),!(t&&t.licenseKey&&t.applicationID&&e))return f.abort();c(E,function(e,n){t[e]||(t[e]=n)});var n=a();s("mark",["onload",n+S.offset],null,"api"),s("timing",["load",n]);var r=m.createElement("script");0===t.agent.indexOf("http://")||0===t.agent.indexOf("https://")?r.src=t.agent:r.src=p+"://"+t.agent,e.parentNode.insertBefore(r,e)}}function i(){"complete"===m.readyState&&o()}function o(){s("mark",["domContent",a()+S.offset],null,"api")}var a=t(22),s=t("handle"),c=t(27),f=t("ee"),u=t(25),d=t(17),l=t(19),p=d.getConfiguration("ssl")===!1?"http":"https",h=window,m=h.document,v="addEventListener",w="attachEvent",g=h.XMLHttpRequest,y=g&&g.prototype,x=!1;NREUM.o={ST:setTimeout,SI:h.setImmediate,CT:clearTimeout,XHR:g,REQ:h.Request,EV:h.Event,PR:h.Promise,MO:h.MutationObserver};var b=""+location,E={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",agent:"js-agent.newrelic.com/nr-1216.min.js"},R=g&&y&&y[v]&&!/CriOS/.test(navigator.userAgent),S=e.exports={offset:a.getLastTimestamp(),now:a,origin:b,features:{},xhrWrappable:R,userAgent:u,disabled:x};if(!x){t(16),t(23),m[v]?(m[v]("DOMContentLoaded",o,l(!1)),h[v]("load",r,l(!1))):(m[w]("onreadystatechange",i),h[w]("onload",r)),s("mark",["firstbyte",a.getLastTimestamp()],null,"api");var O=0}},{}],"wrap-function":[function(t,e,n){function r(t,e){function n(e,n,r,c,f){function nrWrapper(){var o,a,u,l;try{a=this,o=d(arguments),u="function"==typeof r?r(o,a):r||{}}catch(p){i([p,"",[o,a,c],u],t)}s(n+"start",[o,a,c],u,f);try{return l=e.apply(a,o)}catch(h){throw s(n+"err",[o,a,h],u,f),h}finally{s(n+"end",[o,a,l],u,f)}}return a(e)?e:(n||(n=""),nrWrapper[l]=e,o(e,nrWrapper,t),nrWrapper)}function r(t,e,r,i,o){r||(r="");var s,c,f,u="-"===r.charAt(0);for(f=0;f<e.length;f++)c=e[f],s=t[c],a(s)||(t[c]=n(s,u?c+r:r,i,c,o))}function s(n,r,o,a){if(!h||e){var s=h;h=!0;try{t.emit(n,r,o,e,a)}catch(c){i([c,n,r,o],t)}h=s}}return t||(t=u),n.inPlace=r,n.flag=l,n}function i(t,e){e||(e=u);try{e.emit("internal-error",t)}catch(n){}}function o(t,e,n){if(Object.defineProperty&&Object.keys)try{var r=Object.keys(t);return r.forEach(function(n){Object.defineProperty(e,n,{get:function(){return t[n]},set:function(e){return t[n]=e,e}})}),e}catch(o){i([o],n)}for(var a in t)p.call(t,a)&&(e[a]=t[a]);return e}function a(t){return!(t&&t instanceof Function&&t.apply&&!t[l])}function s(t,e){var n=e(t);return n[l]=t,o(t,n,u),n}function c(t,e,n){var r=t[e];t[e]=s(r,n)}function f(){for(var t=arguments.length,e=new Array(t),n=0;n<t;++n)e[n]=arguments[n];return e}var u=t("ee"),d=t(28),l="nr@original",p=Object.prototype.hasOwnProperty,h=!1;e.exports=r,e.exports.wrapFunction=s,e.exports.wrapInPlace=c,e.exports.argsToArray=f},{}]},{},["loader",2,13,4,3]);</script>  <meta name="format-detection" content="telephone=no" />  <link rel="apple-touch-icon" sizes="180x180" href="//oup.silverchair-cdn.com/UI/app/img/v-638654879241847311/apple-touch-icon.png"> <link rel="icon" type="image/png" href="//oup.silverchair-cdn.com/UI/app/img/v-638654879242047735/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//oup.silverchair-cdn.com/UI/app/img/v-638654879241997236/favicon-16x16.png" sizes="16x16"> <link rel="mask-icon" href="//oup.silverchair-cdn.com/UI/app/img/v-638654879242697268/safari-pinned-tab.svg" color="#001C54"> <link rel="icon" href="//oup.silverchair-cdn.com/UI/app/img/v-638654879242147229/favicon.ico"> <link rel="manifest" href="//oup.silverchair-cdn.com/UI/app/img/v-638654879242447968/manifest.json"> <meta name="msapplication-config" content="//oup.silverchair-cdn.com/UI/app/img/v-638654879241847311/browserconfig.xml"> <meta name="theme-color" content="#002f65"> <link rel="stylesheet" type="text/css" href="//oup.silverchair-cdn.com/UI/app/fonts/icons.css" /> <link rel="stylesheet" type="text/css" href="//oup.silverchair-cdn.com/Themes/Client/app/css/v-638669719594245124/site.min.css" /> <link rel="preload" href="https://fonts.googleapis.com/css?family=Merriweather:300,400,400italic,700,700italic|Source+Sans+Pro:400,400italic,700,700italic" as="style" onload="this.onload=null;this.rel='stylesheet'"> <link href="//oup.silverchair-cdn.com/data/SiteBuilderAssetsOriginals/Live/CSS/journals/v-638647548564311250/global.css" rel="stylesheet" type="text/css" /> <link href="//oup.silverchair-cdn.com/data/SiteBuilderAssets/Live/CSS/jcem/v-637435494113107301/Site.css" rel="stylesheet" type="text/css" /> <script> var dataLayer = [{"full_title":"A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study","short_title":"Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study","authors":"Sunni L. Mumford,Enrique F. Schisterman,Anna Maria Siega-Riz,Richard W. Browne,Audrey J. Gaskins,Maurizio Trevisan,Anne Z. Steiner,Julie L. Daniels,Cuilin Zhang,Neil J. Perkins,Jean Wactawski-Wende","issue_and_volume":"Volume 95 | Issue 9","type":"research-article","online_publication_date":"2010-09-01","access_type":"Paid","license_type":"free","event_type":"Login-full-text","supplier_tag":"SC_Journals","object_type":"Article","taxonomy":"taxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00010%7cnodeLabel%3aMedicine+and+Health%7cnodeLevel%3a1%3btaxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00160%7cnodeLabel%3aClinical+Medicine%7cnodeLevel%3a2%3btaxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00250%7cnodeLabel%3aEndocrinology+and+Diabetes%7cnodeLevel%3a3","siteid":"jcem","authzrequired":"true","turnaway_id":"SUB_NONE","doi":"10.1210/jc.2010-0109"}]; </script> <script> (function (w, d, s, l, i) { w[l] = w[l] || []; w[l].push({ 'gtm.start': new Date().getTime(), event: 'gtm.js' }); var f = d.getElementsByTagName(s)[0], j = d.createElement(s), dl = l != 'dataLayer' ? '&l=' + l : ''; j.async = true; j.src = 'https://www.googletagmanager.com/gtm.js?id=' + i + dl; f.parentNode.insertBefore(j, f); })(window, document, 'script', 'dataLayer', 'GTM-W6DD7HV'); </script> <script type="text/javascript"> var App = App || {}; App.LoginUserInfo = { isInstLoggedIn: 0, isIndividualLoggedIn: 0 }; App.CurrentSubdomain = 'jcem'; App.SiteURL = 'academic.oup.com/jcem'; </script> <link href="https://cdn.jsdelivr.net/chartist.js/latest/chartist.min.css" media="print" onload="this.onload=null;this.removeAttribute('media');" rel="stylesheet" type="text/css" /> <script type="application/ld+json"> {"@context":"https://schema.org","@type":"ScholarlyArticle","@id":"https://academic.oup.com/jcem/article/95/9/E80/2835175","name":"A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study","about":["low-density lipoproteins","ldl cholesterol lipoproteins","triglycerides","lipoproteins","cholesterol","estradiol","hormones","high density lipoproteins","menstrual cycle, proliferative phase","luteal phase","menstrual cycle","ovulation","prospective studies","reproductive physiological process","cholesterol measurement test","study of serum","persistence","endogenous estrogens","exogenous estrogens","fasting lipid profile","total cholesterol","outcome measures"],"datePublished":"2010-09-01","isPartOf":{"@id":"https://academic.oup.com/jcem/issue/95/9","@type":"PublicationIssue","issueNumber":"9","datePublished":"2010-09-01","isPartOf":{"@id":"https://academic.oup.com/jcem/jcem","@type":"Periodical","name":"The Journal of Clinical Endocrinology & Metabolism","issn":["1945-7197"]}},"url":"https://dx.doi.org/10.1210/jc.2010-0109","keywords":["low-density lipoproteins","ldl cholesterol lipoproteins","triglycerides","lipoproteins","cholesterol","estradiol","hormones","high density lipoproteins","menstrual cycle, proliferative phase","luteal phase","menstrual cycle","ovulation","prospective studies","reproductive physiological process","cholesterol measurement test","study of serum","persistence","endogenous estrogens","exogenous estrogens","fasting lipid profile","total cholesterol","outcome measures"],"inLanguage":"en","copyrightHolder":"Oxford University Press","copyrightYear":"2024","publisher":"Oxford University Press","author":[{"name":"Mumford, Sunni L.","affiliation":"1 Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852; 2 Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;","@type":"Person"},{"name":"Schisterman, Enrique F.","affiliation":"1 Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;","@type":"Person"},{"name":"Siega-Riz, Anna Maria","affiliation":"2 Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;","@type":"Person"},{"name":"Browne, Richard W.","affiliation":"4 Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;","@type":"Person"},{"name":"Gaskins, Audrey J.","affiliation":"1 Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;","@type":"Person"},{"name":"Trevisan, Maurizio","affiliation":"4 Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214; 5 University of Nevada Health Sciences System (M.T.), Las Vegas, Nevada 89103","@type":"Person"},{"name":"Steiner, Anne Z.","affiliation":"3 University of North Carolina Gillings School of Global Public Health, and Department of Obstetrics and Gynecology (A.Z.S.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;","@type":"Person"},{"name":"Daniels, Julie L.","affiliation":"2 Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;","@type":"Person"},{"name":"Zhang, Cuilin","affiliation":"1 Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;","@type":"Person"},{"name":"Perkins, Neil J.","affiliation":"1 Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;","@type":"Person"},{"name":"Wactawski-Wende, Jean","affiliation":"4 Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;","@type":"Person"}],"description":"Context: Exogenous estrogens have been shown to affect the lipid profile, leading to the hypothesis that endogenous estrogens may have similar effects.Obje","pageStart":"E80","pageEnd":"E85","siteName":"OUP Academic","thumbnailURL":"https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jcem/Issue/95/9/1/m_cover.gif?Expires=1794657379&Signature=1lsyOeFbyG~aZxWAP3unuCBNUVWMK3qeOeJ6OiuwdVQW4cgqsRVMFul28tW61rqBBq5k37JBzBVix-VvIe7OTCbQlaZGN8cvIJNkdzDxGWFb98nJqW~lChTe9fwFyrux1Makjx-ZiM9D3uw41OU2QNtcR7mvFVp6bo13--a51nEO3O1R0yxCXw18NMNmEUcRg9u1hh49XwS~yrZyFe6HSMSdMktJLsxEF5cN1DtCrHtd2DdLN0mbxS8VA4vlXMO9kWlem3u2qMTf76Ld5eESX8b-htTZ42LjcJ4TD3HohKlOCKLHxMxRATp14uo-03RJfF7YwYYTjm9U0msNdE~gAg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA","headline":"A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study","image":"https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jcem/Issue/95/9/1/m_cover.gif?Expires=1794657379&Signature=1lsyOeFbyG~aZxWAP3unuCBNUVWMK3qeOeJ6OiuwdVQW4cgqsRVMFul28tW61rqBBq5k37JBzBVix-VvIe7OTCbQlaZGN8cvIJNkdzDxGWFb98nJqW~lChTe9fwFyrux1Makjx-ZiM9D3uw41OU2QNtcR7mvFVp6bo13--a51nEO3O1R0yxCXw18NMNmEUcRg9u1hh49XwS~yrZyFe6HSMSdMktJLsxEF5cN1DtCrHtd2DdLN0mbxS8VA4vlXMO9kWlem3u2qMTf76Ld5eESX8b-htTZ42LjcJ4TD3HohKlOCKLHxMxRATp14uo-03RJfF7YwYYTjm9U0msNdE~gAg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA","image:alt":"Issue Cover"} </script> <meta property="og:site_name" content="OUP Academic" /> <meta property="og:title" content="A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" /> <meta property="og:description" content="Context: Exogenous estrogens have been shown to affect the lipid profile, leading to the hypothesis that endogenous estrogens may have similar effects.Obje" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://dx.doi.org/10.1210/jc.2010-0109" /> <meta property="og:updated_time" content="" /> <meta property="og:image" content="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jcem/Issue/95/9/1/m_cover.gif?Expires=1794657379&Signature=1lsyOeFbyG~aZxWAP3unuCBNUVWMK3qeOeJ6OiuwdVQW4cgqsRVMFul28tW61rqBBq5k37JBzBVix-VvIe7OTCbQlaZGN8cvIJNkdzDxGWFb98nJqW~lChTe9fwFyrux1Makjx-ZiM9D3uw41OU2QNtcR7mvFVp6bo13--a51nEO3O1R0yxCXw18NMNmEUcRg9u1hh49XwS~yrZyFe6HSMSdMktJLsxEF5cN1DtCrHtd2DdLN0mbxS8VA4vlXMO9kWlem3u2qMTf76Ld5eESX8b-htTZ42LjcJ4TD3HohKlOCKLHxMxRATp14uo-03RJfF7YwYYTjm9U0msNdE~gAg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" /> <meta property="og:image:url" content="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jcem/Issue/95/9/1/m_cover.gif?Expires=1794657379&Signature=1lsyOeFbyG~aZxWAP3unuCBNUVWMK3qeOeJ6OiuwdVQW4cgqsRVMFul28tW61rqBBq5k37JBzBVix-VvIe7OTCbQlaZGN8cvIJNkdzDxGWFb98nJqW~lChTe9fwFyrux1Makjx-ZiM9D3uw41OU2QNtcR7mvFVp6bo13--a51nEO3O1R0yxCXw18NMNmEUcRg9u1hh49XwS~yrZyFe6HSMSdMktJLsxEF5cN1DtCrHtd2DdLN0mbxS8VA4vlXMO9kWlem3u2qMTf76Ld5eESX8b-htTZ42LjcJ4TD3HohKlOCKLHxMxRATp14uo-03RJfF7YwYYTjm9U0msNdE~gAg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" /> <meta property="og:image:secure_url" content="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jcem/Issue/95/9/1/m_cover.gif?Expires=1794657379&Signature=1lsyOeFbyG~aZxWAP3unuCBNUVWMK3qeOeJ6OiuwdVQW4cgqsRVMFul28tW61rqBBq5k37JBzBVix-VvIe7OTCbQlaZGN8cvIJNkdzDxGWFb98nJqW~lChTe9fwFyrux1Makjx-ZiM9D3uw41OU2QNtcR7mvFVp6bo13--a51nEO3O1R0yxCXw18NMNmEUcRg9u1hh49XwS~yrZyFe6HSMSdMktJLsxEF5cN1DtCrHtd2DdLN0mbxS8VA4vlXMO9kWlem3u2qMTf76Ld5eESX8b-htTZ42LjcJ4TD3HohKlOCKLHxMxRATp14uo-03RJfF7YwYYTjm9U0msNdE~gAg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" /> <meta property="og:image:alt" content="Issue Cover" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="citation_author" content="Mumford, Sunni L." /><meta name="citation_author_institution" content="Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;" /><meta name="citation_author_institution" content="Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;" /><meta name="citation_author" content="Schisterman, Enrique F." /><meta name="citation_author_institution" content="Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;" /><meta name="citation_author" content="Siega-Riz, Anna Maria" /><meta name="citation_author_institution" content="Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;" /><meta name="citation_author" content="Browne, Richard W." /><meta name="citation_author_institution" content="Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;" /><meta name="citation_author" content="Gaskins, Audrey J." /><meta name="citation_author_institution" content="Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;" /><meta name="citation_author" content="Trevisan, Maurizio" /><meta name="citation_author_institution" content="Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;" /><meta name="citation_author_institution" content="University of Nevada Health Sciences System (M.T.), Las Vegas, Nevada 89103" /><meta name="citation_author" content="Steiner, Anne Z." /><meta name="citation_author_institution" content="University of North Carolina Gillings School of Global Public Health, and Department of Obstetrics and Gynecology (A.Z.S.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;" /><meta name="citation_author" content="Daniels, Julie L." /><meta name="citation_author_institution" content="Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;" /><meta name="citation_author" content="Zhang, Cuilin" /><meta name="citation_author_institution" content="Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;" /><meta name="citation_author" content="Perkins, Neil J." /><meta name="citation_author_institution" content="Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;" /><meta name="citation_author" content="Wactawski-Wende, Jean" /><meta name="citation_author_institution" content="Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;" /><meta name="citation_title" content="A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" /><meta name="citation_firstpage" content="E80" /><meta name="citation_lastpage" content="E85" /><meta name="citation_doi" content="10.1210/jc.2010-0109" /><meta name="citation_keyword" content="lipoproteins" /><meta name="citation_keyword" content="high density lipoproteins" /><meta name="citation_keyword" content="reproductive physiological process" /><meta name="citation_keyword" content="cholesterol" /><meta name="citation_keyword" content="estradiol" /><meta name="citation_keyword" content="luteal phase" /><meta name="citation_keyword" content="ovulation" /><meta name="citation_keyword" content="menstrual cycle, proliferative phase" /><meta name="citation_keyword" content="fasting lipid profile" /><meta name="citation_keyword" content="exogenous estrogens" /><meta name="citation_keyword" content="low-density lipoproteins" /><meta name="citation_keyword" content="total cholesterol" /><meta name="citation_journal_title" content="The Journal of Clinical Endocrinology & Metabolism" /><meta name="citation_journal_abbrev" content="J Clin Endocrinol Metab" /><meta name="citation_volume" content="95" /><meta name="citation_issue" content="9" /><meta name="citation_publication_date" content="2010/09/01" /><meta name="citation_issn" content="0021-972X" /><meta name="citation_publisher" content="Oxford Academic" /><meta name="citation_reference" content="citation_title=Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial.; citation_author=Rossouw JE; citation_author=Anderson GL; citation_author=Prentice RL; citation_author=LaCroix AZ; citation_author=Kooperberg C; citation_author=Stefanick ML; citation_author=Jackson RD; citation_author=Beresford SA; citation_author=Howard BV; citation_author=Johnson KC; citation_author=Kotchen JM; citation_author=Ockene J; citation_journal_title=JAMA; citation_year=2002; citation_volume=288; citation_pages=321-333; " /><meta name="citation_reference" content="citation_title=Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group.; citation_author=Hulley S; citation_author=Grady D; citation_author=Bush T; citation_author=Furberg C; citation_author=Herrington D; citation_author=Riggs B; citation_author=Vittinghoff E; citation_journal_title=JAMA; citation_year=1998; citation_volume=280; citation_pages=605-613; " /><meta name="citation_reference" content="citation_title=The metabolic impact of oral contraceptives.; citation_author=Krauss RM; citation_author=Burkman Jr RT; citation_journal_title=Am J Obstet Gynecol; citation_year=1992; citation_volume=167; citation_pages=1177-1184; " /><meta name="citation_reference" content="citation_title=Sex differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease.; citation_author=Knopp RH; citation_author=Paramsothy P; citation_author=Retzlaff BM; citation_author=Fish B; citation_author=Walden C; citation_author=Dowdy A; citation_author=Tsunehara C; citation_author=Aikawa K; citation_author=Cheung MC; citation_journal_title=Curr Cardiol Rep; citation_year=2006; citation_volume=8; citation_pages=452-459; " /><meta name="citation_reference" content="citation_title=Multiple beneficial effects of estrogen on lipoprotein metabolism.; citation_author=Knopp RH; citation_author=Zhu X; citation_journal_title=J Clin Endocrinol Metab; citation_year=1997; citation_volume=82; citation_pages=3952-3954; " /><meta name="citation_reference" content="citation_title=Effect of estrogen on very low density lipoprotein and low density lipoprotein subclass metabolism in postmenopausal women.; citation_author=Campos H; citation_author=Walsh BW; citation_author=Judge H; citation_author=Sacks FM; citation_journal_title=J Clin Endocrinol Metab; citation_year=1997; citation_volume=82; citation_pages=3955-3963; " /><meta name="citation_reference" content="citation_title=BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle.; citation_author=Wactawski-Wende J; citation_author=Schisterman EF; citation_author=Hovey KM; citation_author=Howards PP; citation_author=Browne RW; citation_author=Hediger M; citation_author=Liu A; citation_author=Trevisan M; citation_journal_title=Paediatr Perinat Epidemiol; citation_year=2009; citation_volume=23; citation_pages=171-184; " /><meta name="citation_reference" content="citation_title=Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.; citation_author=Friedewald WT; citation_author=Levy RI; citation_author=Fredrickson DS; citation_journal_title=Clin Chem; citation_year=1972; citation_volume=18; citation_pages=499-502; " /><meta name="citation_reference" content="citation_title=Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III).; citation_journal_title=JAMA; citation_year=2001; citation_volume=285; citation_pages=2486-2497; " /><meta name="citation_reference" content="citation_title=Marginal structural models and causal inference in epidemiology.; citation_author=Robins JM; citation_author=Hernán MA; citation_author=Brumback B; citation_journal_title=Epidemiology; citation_year=2000; citation_volume=11; citation_pages=550-560; " /><meta name="citation_reference" content="citation_title=Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein particle size, and apolipoproteins.; citation_author=Lamon-Fava S; citation_author=Fisher EC; citation_author=Nelson ME; citation_author=Evans WJ; citation_author=Millar JS; citation_author=Ordovas JM; citation_author=Schaefer EJ; citation_journal_title=J Clin Endocrinol Metab; citation_year=1989; citation_volume=68; citation_pages=17-21; " /><meta name="citation_reference" content="citation_title=Variations in plasma volume affect total and low-density lipoprotein cholesterol concentrations during the menstrual cycle.; citation_author=Cullinane EM; citation_author=Yurgalevitch SM; citation_author=Saritelli AL; citation_author=Herbert PN; citation_author=Thompson PD; citation_journal_title=Metabolism; citation_year=1995; citation_volume=44; citation_pages=965-971; " /><meta name="citation_reference" content="citation_title=Menstrual cycle effect on plasma lipids.; citation_author=Jones DY; citation_author=Judd JT; citation_author=Taylor PR; citation_author=Campbell WS; citation_author=Nair PP; citation_journal_title=Metabolism; citation_year=1988; citation_volume=37; citation_pages=1-2; " /><meta name="citation_reference" content="citation_title=Lipid and hormonal profile of Panamanian women during the menstrual cycle.; citation_author=De Leon RG; citation_author=Austin KL; citation_author=Richards L; citation_author=Guerrero F; citation_journal_title=Int J Gynecol Obstet; citation_year=1992; citation_volume=39; citation_pages=219-226; " /><meta name="citation_reference" content="citation_title=Changes in lipoprotein composition during the menstrual cycle.; citation_author=Kim HJ; citation_author=Kalkhoff RK; citation_journal_title=Metabolism; citation_year=1979; citation_volume=28; citation_pages=663-668; " /><meta name="citation_reference" content="citation_title=Variation in risk indicators of cardiovascular disease during the menstrual cycle: an investigation of within-subject variations in glutathione peroxidase, haemostatic variables, lipids and lipoproteins in healthy young women.; citation_author=Larsen LF; citation_author=Andersen HR; citation_author=Hansen AB; citation_author=Andersen O; citation_journal_title=Scand J Clin Lab Invest; citation_year=1996; citation_volume=56; citation_pages=241-249; " /><meta name="citation_reference" content="citation_title=Differences in serum lipids, lipoproteins, sex hormone binding globulin and testosterone between the follicular and the luteal phase of the menstrual cycle.; citation_author=Schijf CP; citation_author=van der Mooren MJ; citation_author=Doesburg WH; citation_author=Thomas CM; citation_author=Rolland R; citation_journal_title=Acta Endocrinol (Copenhagen); citation_year=1993; citation_volume=129; citation_pages=130-133; " /><meta name="citation_reference" content="citation_title=In vivo regulation of low-density lipoprotein receptors by estrogen differs at the post-transcriptional level in rat and mouse.; citation_author=Srivastava RA; citation_author=Baumann D; citation_author=Schonfeld G; citation_journal_title=Eur J Biochem; citation_year=1993; citation_volume=216; citation_pages=527-538; " /><meta name="citation_reference" content="citation_title=Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.; citation_author=Zannis VI; citation_author=Chroni A; citation_author=Krieger M; citation_journal_title=J Mol Med; citation_year=2006; citation_volume=84; citation_pages=276-294; " /><meta name="citation_reference" content="citation_title=Identification of scavenger receptor SR-BI as a high density lipoprotein receptor.; citation_author=Acton S; citation_author=Rigotti A; citation_author=Landschulz KT; citation_author=Xu S; citation_author=Hobbs HH; citation_author=Krieger M; citation_journal_title=Science; citation_year=1996; citation_volume=271; citation_pages=518-520; " /><meta name="citation_fulltext_world_readable" content="" /><meta name="citation_pdf_url" content="https://academic.oup.com/jcem/article-pdf/95/9/E80/10412333/jcem0E80.pdf" /><meta name="description" content="Context: Exogenous estrogens have been shown to affect the lipid profile, leading to the hypothesis that endogenous estrogens may have similar effects.Obje" /><meta name="citation_xml_url" content="https://academic.oup.com/jcem/article-xml/95/9/E80/2835175" /> <link rel="canonical" href="https://academic.oup.com/jcem/article-abstract/95/9/E80/2835175" /> <meta name="product_code" content="J_jcem_1996_01_312" /> <meta name="product_code" content="J_JCEM_1996_01_240" /> <meta name="product_code" content="J_JCEM_2008_01_156" /> <meta name="product_code" content="J_JCEM_2007_01_96" /> <meta name="product_code" content="J_JCEM_2008_01_108" /> <meta name="product_code" content="J_jcem_1996_01_288" /> <meta name="product_code" content="J_JCEM_2008_01_120" /> <meta name="product_code" content="J_JCEM_2007_01_48" /> <meta name="product_code" content="J_JCEM_2007_01_60" /> <meta name="product_code" content="J_JCEM_2007_01_72" /> <meta name="product_code" content="J_jcem_1996_01_336" /> <meta name="product_code" content="J_JCEM_2007_01_84" /> <meta name="product_code" content="J_JCEM_2004_01_180" /> <meta name="product_code" content="J_JCEM_2008_01_132" /> <meta name="product_code" content="J_JCEM_2000_01_192" /> <meta name="product_code" content="J_JCEM_2000_01_204" /> <meta name="product_code" content="J_JCEM_2007_01_120" /> <meta name="product_code" content="J_JCEM_2006_01_72" /> <meta name="product_code" content="J_JCEM_2006_01_96" /> <meta name="product_code" content="J_JCEM_2007_01_108" /> <meta name="product_code" content="j_ALLJOURNALS" /> <meta name="product_code" content="J_JCEM_2001_01_168" /> <meta name="product_code" content="J_JCEM_2006_01_132" /> <meta name="product_code" content="J_JCEM_2001_01_192" /> <meta name="product_code" content="J_JCEM_2006_01_60" /> <meta name="product_code" content="J_JCEM_2001_01_120" /> <meta name="product_code" content="J_JCEM_2009_01_132" /> <meta name="product_code" content="J_JCEM_2001_01_132" /> <meta name="product_code" content="J_jcem_1996_01_300" /> <meta name="product_code" content="J_JCEM_2001_01_156" /> <meta name="product_code" content="J_jcem_1996_01_252" /> <meta name="product_code" content="J_JCEM_2010_01_12" /> <meta name="product_code" content="J_JCEM_2010_01_24" /> <meta name="product_code" content="J_JCEM_2010_01_48" /> <meta name="product_code" content="J_JCEM_2009_01_72" /> <meta name="product_code" content="J_JCEM_1996_01_264" /> <meta name="product_code" content="J_JCEM_2009_01_84" /> <meta name="product_code" content="J_JCEM_2009_01_93" /> <meta name="product_code" content="J_JCEM_2009_01_96" /> <meta name="product_code" content="J_JCEM_2009_01_36" /> <meta name="product_code" content="J_JCEM_2009_01_48" /> <meta name="product_code" content="J_JCEM_2009_01_60" /> <meta name="product_code" content="J_JCEM_2008_01_96" /> <meta name="product_code" content="J_JCEM_2009_01_108" /> <meta name="product_code" content="J_JCEM_2009_01_144" /> <meta name="product_code" content="J_JCEM_2009_01_24" /> <meta name="product_code" content="J_JCEM_2008_01_48" /> <meta name="product_code" content="J_JCEM_2008_01_60" /> <meta name="product_code" content="J_JCEM_2008_01_72" /> <meta name="product_code" content="J_JCEM_2008_01_84" /> <meta name="product_code" content="J_JCEM_2008_01_36" /> <meta name="product_code" content="J_JCEM_2003_01_108" /> <meta name="product_code" content="J_JCEM_2003_01_120" /> <meta name="product_code" content="J_JCEM_2002_01_144" /> <meta name="product_code" content="J_JCEM_2002_01_180" /> <meta name="product_code" content="J_JCEM_2002_01_228" /> <meta name="product_code" content="J_JCEM_2002_01_108" /> <meta name="product_code" content="J_JCEM_2010_01_96" /> <meta name="product_code" content="J_JCEM_2010_01_120" /> <meta name="product_code" content="J_JCEM_2003_01_180" /> <meta name="product_code" content="J_JCEM_2002_01_192" /> <meta name="product_code" content="J_JCEM_2007_01_132" /> <meta name="product_code" content="J_JCEM_2006_01_144" /> <meta name="product_code" content="J_JCEM_2005_01_156" /> <meta name="product_code" content="J_JCEM_2004_01_168" /> <meta name="product_code" content="COMP_RetainedFBI" /> <meta name="product_code" content="J_JCEM_2003_01_96" /> <meta name="product_code" content="J_JCEM_2004_01_84" /> <meta name="product_code" content="J_JCEM_2008_01_105" /> <meta name="product_code" content="J_JCEM_2000_01_216" /> <meta name="product_code" content="J_JCEM_2010_01_60" /> <meta name="product_code" content="J_JCEM_2010_01_72" /> <meta name="product_code" content="J_JCEM_2010_01_84" /> <meta name="product_code" content="J_JCEM_2001_01_204" /> <meta name="product_code" content="J_JCEM_2007_01_156" /> <meta name="product_code" content="J_JCEM_2005_01_84" /> <meta name="product_code" content="J_JCEM_2006_01_108" /> <meta name="product_code" content="J_JCEM_2006_01_120" /> <meta name="product_code" content="J_JCEM_1996_01_276" /> <meta name="product_code" content="J_JCEM_1996_01_9999" /> <meta name="product_code" content="J_JCEM_2005_01_132" /> <meta name="product_code" content="J_JCEM_2005_01_144" /> <meta name="product_code" content="J_JCEM_2000_01_132" /> <meta name="product_code" content="J_JCEM_2004_01_96" /> <meta name="product_code" content="J_JCEM_2000_01_144" /> <meta name="product_code" content="J_JCEM_2005_01_108" /> <meta name="product_code" content="J_JCEM_2000_01_168" /> <meta name="product_code" content="J_JCEM_1998_01_216" /> <meta name="product_code" content="J_jcem_1996_01_180" /> <meta name="product_code" content="J_JCEM_2003_01_132" /> <meta name="product_code" content="J_JCEM_2004_01_144" /> <meta name="product_code" content="J_JCEM_2004_01_156" /> <meta name="product_code" content="J_JCEM_2004_01_120" /> <meta name="product_code" content="J_JCEM_2004_01_132" /> <meta name="product_code" content="J_JCEM_2003_01_144" /> <meta name="product_code" content="J_JCEM_2003_01_168" /> <meta name="product_code" content="J_2835175" /> <meta name="product_code" content="I_94309" /> <script> var SCM = SCM || {}; SCM.pubGradeAdsEnabled = true; SCM.pubGradeJSLibrary = 'https://cdn.pbgrd.com/core-oup-new.js'; </script> <script async="async" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; </script> <script type='text/javascript'> var gptAdSlots = []; googletag.cmd.push(function() { var mapping_ad1 = googletag.sizeMapping() .addSize([1024, 0], [[970, 90], [728, 90]]) .addSize([768, 0], [728, 90]) .addSize([0, 0], [320, 50]) .build(); gptAdSlots["ad1"] = googletag.defineSlot('/9309/jcem_InFront_Ad1', [[970, 90], [728, 90], [320, 50]], 'adBlockHeader') .defineSizeMapping(mapping_ad1) .addService(googletag.pubads()); var mapping_ad2 = googletag.sizeMapping() .addSize([768, 0], [[300, 250], [300, 600], [160, 600]]) .build(); gptAdSlots["ad2"] = googletag.defineSlot('/9309/jcem_InFront_Ad2', [[300, 250], [160, 600], [300, 600]], 'adBlockMainBodyTop') .defineSizeMapping(mapping_ad2) .addService(googletag.pubads()); var mapping_ad3 = googletag.sizeMapping() .addSize([768, 0], [[300, 250], [300, 600], [160, 600]]) .build(); gptAdSlots["ad3"] = googletag.defineSlot('/9309/jcem_InFront_Ad3', [[300, 250], [160, 600], [300, 600]], 'adBlockMainBodyBottom') .defineSizeMapping(mapping_ad3) .addService(googletag.pubads()); var mapping_ad4 = googletag.sizeMapping() .addSize([0,0], [320, 50]) .addSize([768, 0], [728, 90]) .build(); gptAdSlots["ad4"] = googletag.defineSlot('/9309/jcem_InFront_Ad4', [728, 90], 'adBlockFooter') .defineSizeMapping(mapping_ad4) .addService(googletag.pubads()); var mapping_ad6 = googletag.sizeMapping() .addSize([1024, 0], [[970, 90], [728, 90]]) .addSize([768, 0], [728, 90]) .addSize([0, 0], [320, 50]) .build(); gptAdSlots["ad6"] = googletag.defineSlot('/9309/jcem_InFront_Ad6', [[728, 90], [970, 90]], 'adBlockStickyFooter') .defineSizeMapping(mapping_ad6) .addService(googletag.pubads()); gptAdSlots["adInterstitial"] = googletag.defineOutOfPageSlot('/9309/jcem_Interstitial_Ad', googletag.enums.OutOfPageFormat.INTERSTITIAL) .addService(googletag.pubads()); googletag.pubads().addEventListener('slotRenderEnded', function (event) { if (!event.isEmpty) { $('.js-' + event.slot.getSlotElementId()).each(function () { if ($(this).find('iframe').length) { $(this).removeClass('hide'); } }); } }); googletag.pubads().addEventListener('impressionViewable', function (event) { if (!event.isEmpty) { $('.js-' + event.slot.getSlotElementId()).each(function () { var $adblockDiv = $(this).find('.js-adblock'); var $adText = $(this).find('.js-adblock-advertisement-text'); if ($adblockDiv && $adblockDiv.is(':visible') && $adblockDiv.find('*').length > 1) { $adText.removeClass('hide'); App.CenterAdBlock.Init($adblockDiv, $adText); } else { $adText.addClass('hide'); } //Initialize logic for Sticky Footer Ad var $stickyFooterDiv = $(this).parents('.js-sticky-footer-ad'); if ($stickyFooterDiv && $stickyFooterDiv.is(':visible') && $stickyFooterDiv.find('*').length > 1) { App.StickyFooterAd.Init(); } }); } }); googletag.pubads().setTargeting("jnlspage", "article-abstract"); googletag.pubads().setTargeting("jnlsurl", "jcem/article-abstract/95/9/E80/2835175"); googletag.pubads().enableSingleRequest(); googletag.pubads().disableInitialLoad(); googletag.pubads().collapseEmptyDivs(); }); </script> <input type="hidden" class="hfInterstitial" data-interstitiallinks="jcem/issue,jcem/advance-articles,jcem/advance-article,jcem/supplements,jcem/article,jcem/article-abstract,jcem/pages" data-subdomain="jcem" /> <script type="text/javascript"> googletag.cmd.push(function () { googletag.pubads().setTargeting("jnlsdoi", "10.1210/jc.2010-0109"); googletag.enableServices(); }); </script> <script type="text/javascript"> var NTPT_PGEXTRA= 'event_type=Login-full-text&supplier_tag=SC_Journals&object_type=Article&taxonomy=taxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00010%7cnodeLabel%3aMedicine+and+Health%7cnodeLevel%3a1%3btaxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00160%7cnodeLabel%3aClinical+Medicine%7cnodeLevel%3a2%3btaxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00250%7cnodeLabel%3aEndocrinology+and+Diabetes%7cnodeLevel%3a3&siteid=jcem&authzrequired=true&turnaway_id=SUB_NONE&doi=10.1210/jc.2010-0109'; </script> <script src="https://scholar.google.com/scholar_js/casa.js" async></script> </head> <body data-sitename="thejournalofclinicalendocrinology&metabolism" class="off-canvas pg_Article pg_article " theme-jcem data-sitestyletemplate="Journal" > <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-W6DD7HV" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <a href="#skipNav" class="skipnav">Skip to Main Content</a> <input id="hdnSiteID" name="hdnSiteID" type="hidden" value="5591" /><input id="hdnAdDelaySeconds" name="hdnAdDelaySeconds" type="hidden" value="8000" /><input id="hdnAdConfigurationTop" name="hdnAdConfigurationTop" type="hidden" value="scrolldelay" /><input id="hdnAdConfigurationRightRail" name="hdnAdConfigurationRightRail" type="hidden" value="sticky" /> <div class="master-container js-master-container"> <section class="master-header row js-master-header vt-site-page-header"> <div class="widget widget-SitePageHeader widget-instance-SitePageHeader"> <div class="ad-banner js-ad-banner-header"> <div class="widget widget-AdBlock widget-instance-HeaderAd"> <div class="js-adBlock-parent-wrap adblock-parent-wrap"> <div class="adBlockHeader-wrap js-adBlockHeader hide"> <div id="adBlockHeader" class="js-adblock at-adblock" data-lazy-load-margin="150"> <script> googletag.cmd.push(function () { googletag.display('adBlockHeader'); }); </script> </div> <div class="advertisement-text at-adblock js-adblock-advertisement-text hide">Advertisement</div> </div> </div> </div> </div> <div class="oup-header sigma "> <div class="center-inner-row"> <div class="oup-header-logo"> <a href="/"> <img src="//oup.silverchair-cdn.com/UI/app/svg/umbrella/oxford-academic-logo.svg" alt="Oxford Academic" class="oup-header-image at-oup-header-image " /> </a> </div> <div class="widget widget-CustomNavLinks widget-instance-CustomNavLinksDeskTop"> <div class="custom-nav-links-box"> <div class="custom-nav-link"> <a href="/journals">Journals</a> </div> <div class="custom-nav-link"> <a href="/books">Books</a> </div> </div> </div> <ul class="oup-header-menu account-menu sigma-account-menu "> <li class="oup-header-menu-item mobile"> <a href="javascript:;" class="mobile-dropdown-toggle mobile-search-toggle"> <i class="icon-menu_search"><span class="screenreader-text">Search Menu</span></i> </a> </li> <li class="oup-header-menu-item mobile info-icon-menu-item"> <a href="/pages/information" target="_blank" class="at-info-button sigma-info-wrapper" role="button"> <img class="sigma-info-icon" src="//oup.silverchair-cdn.com/UI/app/svg/i.svg" alt="Information" /> </a> </li> <li class="oup-header-menu-item mobile account-icon-menu-item"> <a href="javascript:;" class="account-button js-account-button at-account-button " role="button" data-turnawayparams="journal%3djcem"> <img class="sigma-account-icon" src="//oup.silverchair-cdn.com/UI/app/svg/account.svg" alt="Account" /> </a> </li> <li class="oup-header-menu-item mobile"> <a href="javascript:;" class="mobile-dropdown-toggle mobile-nav-toggle"> <i class="icon-menu_hamburger"><span class="screenreader-text">Menu</span></i> </a> </li> <li class="oup-header-menu-item desktop info-icon-menu-item"> <a href="/pages/information" target="_blank" class="at-info-button sigma-info-wrapper" role="button"> <img class="sigma-info-icon" src="//oup.silverchair-cdn.com/UI/app/svg/i.svg" alt="Information" /> </a> </li> <li class="oup-header-menu-item desktop account-icon-menu-item"> <a href="javascript:;" class="account-button js-account-button at-account-button sigma-logo-wrapper" role="button" data-turnawayparams="journal%3djcem"> <img class="sigma-account-icon" src="//oup.silverchair-cdn.com/UI/app/svg/account.svg" alt="Account" /> </a> </li> <li class="oup-header-menu-item desktop account-icon-menu-item"> <div class="widget widget-SeamlessAccess widget-instance-SitePageHeader"> <a href="javascript:;" class="js-shibboleth-action seamless-access-button seamless-button-header button-call-to-action at-institutional-sign-in" rel="nofollow" data-action-type="" data-entity-id=""> <span class="seamless-access-text">Sign in through your institution</span> </a> </div> </li> </ul> <div class="login-box-placeholder js-login-box-placeholder hide"> <div class="spinner"></div> </div> </div> </div> <div class="dropdown-panel-wrap"> <div class="dropdown-panel mobile-search-dropdown"> <div class="mobile-search-inner-wrap"> <div class="navbar-search"> <div class="mobile-microsite-search"> <label for="SitePageHeader-mobile-navbar-search-filter" class="screenreader-text js-mobile-navbar-search-filter-label"> Navbar Search Filter </label> <select class="mobile-navbar-search-filter js-mobile-navbar-search-filter at-navbar-search-filter" id="SitePageHeader-mobile-navbar-search-filter"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="">The Journal of Clinical Endocrinology & Metabolism</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Issue">This issue</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Parent">Endocrine Society Journals</option> <optgroup class="navbar-search-optgroup" label="Search across Oxford Academic"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00160">Clinical Medicine</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00250">Endocrinology and Diabetes</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00010">Medicine and Health</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Books">Books</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Journals">Journals</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Umbrella">Oxford Academic</option> </optgroup> </select> <label for="SitePageHeader-mobile-microsite-search-term" class="screenreader-text js-mobile-microsite-search-term-label"> Mobile Enter search term </label> <input class="mobile-search-input mobile-microsite-search-term js-mobile-microsite-search-term at-microsite-search-term" type="text" maxlength="255" placeholder="Search" id="SitePageHeader-mobile-microsite-search-term"> <a href="javascript:;" class="mobile-microsite-search-icon mobile-search-submit icon-menu_search"> <span class="screenreader-text">Search</span> </a> </div> </div> </div> </div> <div class="dropdown-panel mobile-nav-dropdown"> <ul class="site-menu site-menu-lvl-0 at-site-menu"> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717856"> <a href="/jcem/issue" class="nav-link"> Issues </a> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717851"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> More Content <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717857"> <a href="/jcem/advance-articles" class="nav-link"> Advance Articles </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717858"> <a href="https://academic.oup.com/endocrinesociety/pages/thematic_issues" class="nav-link"> Thematic Issues </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717859"> <a href="https://www.endocrine.org/clinical-practice-guidelines" class="nav-link"> Clinical Practice Guidelines </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717860"> <a href="https://academic.oup.com/jcem/supplements" class="nav-link"> Supplements </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717861"> <a href="https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series" class="nav-link"> Podcasts </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717852"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> ES Journals <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717862"> <a href="https://academic.oup.com/edrv" class="nav-link"> Endocrine Reviews </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717863"> <a href="https://academic.oup.com/endo" class="nav-link"> Endocrinology </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717864"> <a href="https://academic.oup.com/jes" class="nav-link"> Journal of the Endocrine Society </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717865"> <a href="/jcem/advance-articles" class="nav-link"> The Journal of Clinical Endocrinology & Metabolism </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717866"> <a href="https://academic.oup.com/jcemcr" class="nav-link"> JCEM Case Reports </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717867"> <a href="https://academic.oup.com/mend" class="nav-link"> Molecular Endocrinology (Archives) </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717868"> <a href="https://academic.oup.com/endocrinesociety" class="nav-link"> Endocrine Society Journals </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717853"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> Submit <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717869"> <a href="/jcem/pages/Author_Guidelines" class="nav-link"> Author Guidelines </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717870"> <a href="https://www.editorialmanager.com/jclinendometab/default.aspx" class="nav-link"> Submission Site </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717871"> <a href="/jcem/pages/Author_Guidelines#charges" class="nav-link"> Open Access </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717872"> <a href="/jcem/pages/why-publish" class="nav-link"> Why Publish with The Journal of Clinical Endocrinology & Metabolism? </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717873"> <a href="https://academic.oup.com/endocrinesociety/pages/predatory-publishing" class="nav-link"> Notice about Predatory Publishing </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717874"> <a href="/jcem/subscribe" class="nav-link"> Purchase </a> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717854"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> Advertise <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717875"> <a href="https://academic.oup.com/advertising-and-corporate-services/pages/jcem-media-kit" class="nav-link"> Advertising & Corporate Services </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717876"> <a href="https://academic.oup.com/advertising-and-corporate-services/pages/supplements" class="nav-link"> Reprints, ePrints, Supplements </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717877"> <a href="https://academic.oup.com/advertising-and-corporate-services/pages/journals-licensing" class="nav-link"> Licensing </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717855"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> About <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717878"> <a href="/jcem/pages/About" class="nav-link"> About The Journal of Clinical Endocrinology & Metabolism </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717879"> <a href="/jcem/pages/Editorial_Board" class="nav-link"> Editorial Board </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717880"> <a href="https://academic.oup.com/endocrinesociety/pages/author_resource_center" class="nav-link"> Author Resources </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717881"> <a href=" https://academic.oup.com/endocrinesociety/pages/reviewer_resource_center" class="nav-link"> Reviewer Resources </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717882"> <a href="https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions" class="nav-link"> Rights & Permissions </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717883"> <a href="https://academic.oup.com/journals/pages/help/journal_alerts" class="nav-link"> Alerts </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717884"> <a href="https://academic.oup.com/endocrinesociety/pages/member_access" class="nav-link"> Member Access </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717885"> <a href="http://www.endocrine.org/endocareers" class="nav-link"> Journals Career Network </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717886"> <a href="https://academic.oup.com/endocrinesociety/pages/terms_and_conditions" class="nav-link"> Terms and Conditions </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-custom"> <a href="/journals" class="nav-link">Journals on Oxford Academic</a> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-custom"> <a href="/books" class="nav-link">Books on Oxford Academic</a> </li> </ul> </div> </div> <div class="journal-header journal-bg"> <div class="center-inner-row"> <div class="site-parent-link-wrap"> <a href="//academic.oup.com/endocrinesociety" class="site-parent-link">Endocrine Society Journals</a> </div> <a href="/jcem" class="journal-logo-container"> <img id="logo-TheJournalofClinicalEndocrinology&Metabolism" class="journal-logo" src="//oup.silverchair-cdn.com/data/SiteBuilderAssets/Live/Images/jcem/jcem_title729907635.svg" alt="The Journal of Clinical Endocrinology & Metabolism" /> </a> <div class="society-logo-block"> <div class="society-block-inner-wrap"> <a href="https://www.endocrine.org/" target="" class="society-logo-container"> <img id="logo-EndocrineSociety" class="society-logo" src="//oup.silverchair-cdn.com/data/SiteBuilderAssets/Live/Images/jcem/jcem_h1-392644295.svg" alt="Endocrine Society" /> </a> </div> </div> </div> </div> <div class="navbar"> <div class="center-inner-row"> <nav class="navbar-menu"> <ul class="site-menu site-menu-lvl-0 at-site-menu"> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717856"> <a href="/jcem/issue" class="nav-link"> Issues </a> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717851"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> More Content <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717857"> <a href="/jcem/advance-articles" class="nav-link"> Advance Articles </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717858"> <a href="https://academic.oup.com/endocrinesociety/pages/thematic_issues" class="nav-link"> Thematic Issues </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717859"> <a href="https://www.endocrine.org/clinical-practice-guidelines" class="nav-link"> Clinical Practice Guidelines </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717860"> <a href="https://academic.oup.com/jcem/supplements" class="nav-link"> Supplements </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717861"> <a href="https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series" class="nav-link"> Podcasts </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717852"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> ES Journals <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717862"> <a href="https://academic.oup.com/edrv" class="nav-link"> Endocrine Reviews </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717863"> <a href="https://academic.oup.com/endo" class="nav-link"> Endocrinology </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717864"> <a href="https://academic.oup.com/jes" class="nav-link"> Journal of the Endocrine Society </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717865"> <a href="/jcem/advance-articles" class="nav-link"> The Journal of Clinical Endocrinology & Metabolism </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717866"> <a href="https://academic.oup.com/jcemcr" class="nav-link"> JCEM Case Reports </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717867"> <a href="https://academic.oup.com/mend" class="nav-link"> Molecular Endocrinology (Archives) </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717868"> <a href="https://academic.oup.com/endocrinesociety" class="nav-link"> Endocrine Society Journals </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717853"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> Submit <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717869"> <a href="/jcem/pages/Author_Guidelines" class="nav-link"> Author Guidelines </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717870"> <a href="https://www.editorialmanager.com/jclinendometab/default.aspx" class="nav-link"> Submission Site </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717871"> <a href="/jcem/pages/Author_Guidelines#charges" class="nav-link"> Open Access </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717872"> <a href="/jcem/pages/why-publish" class="nav-link"> Why Publish with The Journal of Clinical Endocrinology & Metabolism? </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717873"> <a href="https://academic.oup.com/endocrinesociety/pages/predatory-publishing" class="nav-link"> Notice about Predatory Publishing </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717874"> <a href="/jcem/subscribe" class="nav-link"> Purchase </a> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717854"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> Advertise <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717875"> <a href="https://academic.oup.com/advertising-and-corporate-services/pages/jcem-media-kit" class="nav-link"> Advertising & Corporate Services </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717876"> <a href="https://academic.oup.com/advertising-and-corporate-services/pages/supplements" class="nav-link"> Reprints, ePrints, Supplements </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717877"> <a href="https://academic.oup.com/advertising-and-corporate-services/pages/journals-licensing" class="nav-link"> Licensing </a> </li> </ul> </li> <li class="site-menu-item site-menu-lvl-0 at-site-menu-item" id="site-menu-item-1717855"> <a href="javascript:;" class="nav-link js-nav-dropdown at-nav-dropdown" role="button" aria-expanded="false"> About <i class="desktop-nav-arrow icon-general-arrow-filled-down arrow-icon"></i> </a> <i class="mobile-nav-arrow icon-general_arrow-down"></i> <ul class="site-menu site-menu-lvl-1 at-site-menu"> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717878"> <a href="/jcem/pages/About" class="nav-link"> About The Journal of Clinical Endocrinology & Metabolism </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717879"> <a href="/jcem/pages/Editorial_Board" class="nav-link"> Editorial Board </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717880"> <a href="https://academic.oup.com/endocrinesociety/pages/author_resource_center" class="nav-link"> Author Resources </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717881"> <a href=" https://academic.oup.com/endocrinesociety/pages/reviewer_resource_center" class="nav-link"> Reviewer Resources </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717882"> <a href="https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions" class="nav-link"> Rights & Permissions </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717883"> <a href="https://academic.oup.com/journals/pages/help/journal_alerts" class="nav-link"> Alerts </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717884"> <a href="https://academic.oup.com/endocrinesociety/pages/member_access" class="nav-link"> Member Access </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717885"> <a href="http://www.endocrine.org/endocareers" class="nav-link"> Journals Career Network </a> </li> <li class="site-menu-item site-menu-lvl-1 at-site-menu-item" id="site-menu-item-1717886"> <a href="https://academic.oup.com/endocrinesociety/pages/terms_and_conditions" class="nav-link"> Terms and Conditions </a> </li> </ul> </li> </ul> </nav> <div class="navbar-search-container js-navbar-search-container"> <a href="javascript:;" class="navbar-search-close js_close-navsearch">Close</a> <div class="navbar-search"> <div class="microsite-search"> <label for="SitePageHeader-navbar-search-filter" class="screenreader-text js-navbar-search-filter-label"> Navbar Search Filter </label> <select class="navbar-search-filter js-navbar-search-filter at-navbar-search-filter" id="SitePageHeader-navbar-search-filter"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="">The Journal of Clinical Endocrinology & Metabolism</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Issue">This issue</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Parent">Endocrine Society Journals</option> <optgroup class="navbar-search-optgroup" label="Search across Oxford Academic"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00160">Clinical Medicine</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00250">Endocrinology and Diabetes</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00010">Medicine and Health</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Books">Books</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Journals">Journals</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Umbrella">Oxford Academic</option> </optgroup> </select> <label for="SitePageHeader-microsite-search-term" class="screenreader-text js-microsite-search-term-label"> Enter search term </label> <input class="navbar-search-input microsite-search-term js-microsite-search-term at-microsite-search-term" type="text" maxlength="255" placeholder="Search" id="SitePageHeader-microsite-search-term"> <a href="javascript:;" class="microsite-search-icon navbar-search-submit icon-menu_search"> <span class="screenreader-text">Search</span> </a> </div> </div> <input id="hfCurrentBookSearch" name="hfCurrentBookSearch" type="hidden" value="" /><input id="hfCurrentBookScope" name="hfCurrentBookScope" type="hidden" value="CurrentBook" /><input id="hfBookSiteScope" name="hfBookSiteScope" type="hidden" value="Books" /><input id="hfSeriesScope" name="hfSeriesScope" type="hidden" value="taxWithOr" /><input id="hfParentSiteName" name="hfParentSiteName" type="hidden" value="Endocrine Society Journals" /><input id="hfParentSiteUrl" name="hfParentSiteUrl" type="hidden" value="academic.oup.com/endocrinesociety" /><input id="hfSiteID" name="hfSiteID" type="hidden" value="5591" /><input id="hfParentSiteID" name="hfParentSiteID" type="hidden" value="5590" /><input id="hfJournalSiteScope" name="hfJournalSiteScope" type="hidden" value="Journals" /><input id="hfParentSiteScope" name="hfParentSiteScope" type="hidden" value="Parent" /><input id="hfDefaultSearchURL" name="hfDefaultSearchURL" type="hidden" value="search-results?page=1&q=" /><input id="hfIssueSearch" name="hfIssueSearch" type="hidden" value="&fl_IssueID=94309" /><input id="hfIssueSiteScope" name="hfIssueSiteScope" type="hidden" value="Issue" /><input id="hfUmbrellaScope" name="hfUmbrellaScope" type="hidden" value="Umbrella" /><input id="hfUmbrellaSiteUrl" name="hfUmbrellaSiteUrl" type="hidden" value="academic.oup.com" /><input id="hfUmbrellaSiteId" name="hfUmbrellaSiteId" type="hidden" value="191" /><input id="hfDefaultAdvancedSearchUrl" name="hfDefaultAdvancedSearchUrl" type="hidden" value="advanced-search?page=1&q=" /><input id="hfTaggedCollectionScope" name="hfTaggedCollectionScope" type="hidden" value="" /> <div class="navbar-search-advanced"><a href="/jcem/advanced-search" class="advanced-search js-advanced-search">Advanced Search</a></div> </div> <div class="navbar-search-collapsed"><a href="javascript:;" class="icon-menu_search js_expand-navsearch"><span class="screenreader-text">Search Menu</span></a></div> </div> </div> <input type="hidden" name="searchScope" id="hfSolrJournalID" value="" /> <input type="hidden" id="hfSolrJournalName" value="" /> <input type="hidden" id="hfSolrMaxAllowSearchChar" value="100" /> <input type="hidden" id="hfJournalShortName" value="" /> <input type="hidden" id="hfSearchPlaceholder" value="" /> <input type="hidden" name="hfGlobalSearchSiteURL" id="hfGlobalSearchSiteURL" value="" /> <input type="hidden" name="hfSearchSiteURL" id="hfSiteURL" value="academic.oup.com/jcem" /> <input type="hidden" name="RedirectSiteUrl" id="RedirectSiteUrl" value="httpszazjzjacademiczwoupzwcom" /> <script type="text/javascript"> (function () { var hfSiteUrl = document.getElementById('hfSiteURL'); var siteUrl = hfSiteUrl.value; var subdomainIndex = siteUrl.indexOf('/'); hfSiteUrl.value = location.host + (subdomainIndex >= 0 ? siteUrl.substring(subdomainIndex) : ''); })(); </script> <input id="routename" name="RouteName" type="hidden" value="jcem" /> </div> </section> <div class="widget widget-SitewideBanner widget-instance-"> </div> <div id="main" class="content-main js-main ui-base"> <section class="master-main row"> <div class="center-inner-row no-overflow"> <div id="skipNav" tabindex="-1"></div> <div class="page-column-wrap"> <div id="InfoColumn" class="page-column page-column--left js-left-nav-col"> <div class="mobile-content-topbar hide"> <button class="toggle-left-col toggle-left-col__article">Article Navigation</button> </div> <div class="info-inner-wrap js-left-nav"> <button class="toggle-left-col__close btn-as-icon icon-general-close"> <span class="screenreader-text">Close mobile search navigation</span> </button> <div class="responsive-nav-title">Article Navigation</div> <div class="info-widget-wrap"> <div class="widget widget-IssueInfo widget-instance-OUP_IssueInfo_Article"> <div id="issueInfo-OUP_IssueInfo_Article" class="article-info-wrap clearfix"> <i class="icon-general-close mobile-nav-btn nav-open"></i> <a class="article-issue-link" href="/jcem/issue/95/9"> <div class="article-issue-img"> <img id="issueImage" class="fb-featured-image" src="https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jcem/Issue/95/9/1/m_cover.gif?Expires=1735423714&Signature=Y67pjntouLRgVL27ttxi2pnS39AuXC3xBr0uouKHamDdIHKVXcZTqf7cqW3p8T8bg5PCs4WBHWfVSTf6evveSMaDhPGcY9peQGgoihwAfMfYl4j4MFEc8LXQofnY8ZMM0zEUItXEqLtrrxNUTyfUiHEZ2aunBtOR1jRK59744E20bua~rfWevBWZLCBrV4QuFMPBYoDfjXzM86h1Fz89azdOGRFXBYMrtc8lxpetjLMz9Cw2SHzroSKgv9a6LNgZP~2XA28HDBdMwQo7ZsTgb9vXDUjwa4G7Pvyev0vc3dBcm0dObbMGbZFrKd6lgQJVhsRCkagXZ6T77JCptKBoRw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA" alt="Issue Cover" /> </div> <div class="article-issue-info"> <div class="volume-issue__wrap"> <div class="volume trailing-comma">Volume 95</div> <div class="issue">Issue 9</div> </div> <div class="ii-pub-date"> 1 September 2010 </div> </div> </a> </div> </div> <div class="content-nav"> </div> <div class="widget widget-ArticleNavLinks widget-instance-OUP_ArticleNavLinks_Article"> <ul class="inline-list"> <li class="prev arrow"> <a href="/jcem/article/95/9/E75/2835173">< Previous</a> </li> <li class="next arrow"> <a href="/jcem/article/95/9/E86/2835179">Next ></a> </li> </ul> </div> </div> </div> </div> <div class="sticky-toolbar js-sticky-toolbar"></div> <div id="ContentColumn" class="page-column page-column--center"> <div class="article-browse-top article-browse-mobile-nav js-mobile-nav"> <div class="article-browse-mobile-nav-inner js-mobile-nav-inner"> <button class="toggle-left-col toggle-left-col__article btn-as-link"> Article Navigation </button> </div> </div> <div class="article-browse-top article-browse-mobile-nav mobile-sticky-toolbar js-mobile-nav-sticky"> <div class="article-browse-mobile-nav-inner"> <button class="toggle-left-col toggle-left-col__article btn-as-link"> Article Navigation </button> </div> </div> <div class="content-inner-wrap"> <div class="widget widget-ArticleTopInfo widget-instance-OUP_Abstract_ArticleTop_Info_Widget"> <div class="module-widget article-top-widget"> <div class="access-state-logos all-viewports"> <span class="journal-info__format-label">Journal Article</span> </div> <div class="widget-items"> <div class="title-wrap"> <h1 class="wi-article-title article-title-main accessible-content-title at-articleTitle"> A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study <i class='' title='' ></i> </h1> <a href="#no-access-message" class="get-access get-access-jumplink at-get-access-jumplink js-no-access-jumplink"> <span class="get-access-text">Get access</span> <img class='get-access-icon' src='/UI/app/svg/chevron-right-white.svg' alt='Arrow' aria-hidden='true'> </a> </div> <div class="wi-authors at-ArticleAuthors"> <div class="al-authors-list"> <div class="meta-authors--limited"> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Sunni L. Mumford</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Sunni L. Mumford </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">1</span>Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;</div><div class="aff"><span class="label title-label">2</span>Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Sunni+L.+Mumford" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Mumford Sunni L.%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Enrique F. Schisterman</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Enrique F. Schisterman <span class="info-card-footnote"><span class="xrefLink" id="jumplink-cor1"></span><a href="javascript:;" reveal-id="cor1" data-open="cor1" class="link link-ref link-reveal xref-default"></a></span> </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">1</span>Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;</div> </div> <div class="info-author-correspondence"> <div content-id="cor1"><span class="label title-label">*</span>Address all correspondence and requests for reprints to: Enrique F. Schisterman, Ph.D., Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development, 6100 Executive Boulevard 7B03, Rockville, Maryland 20852.</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Enrique+F.+Schisterman" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Schisterman Enrique F.%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Anna Maria Siega-Riz</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Anna Maria Siega-Riz </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">2</span>Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Anna+Maria+Siega-Riz" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Siega-Riz Anna Maria%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Richard W. Browne</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Richard W. Browne </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">4</span>Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Richard+W.+Browne" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Browne Richard W.%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Audrey J. Gaskins</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Audrey J. Gaskins </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">1</span>Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Audrey+J.+Gaskins" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Gaskins Audrey J.%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Maurizio Trevisan</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Maurizio Trevisan </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">4</span>Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;</div><div class="aff"><span class="label title-label">5</span>University of Nevada Health Sciences System (M.T.), Las Vegas, Nevada 89103</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Maurizio+Trevisan" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Trevisan Maurizio%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Anne Z. Steiner</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Anne Z. Steiner </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">3</span>University of North Carolina Gillings School of Global Public Health, and Department of Obstetrics and Gynecology (A.Z.S.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Anne+Z.+Steiner" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Steiner Anne Z.%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Julie L. Daniels</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Julie L. Daniels </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">2</span>Department of Epidemiology (S.L.M., A.M.S.-R., J.L.D.), University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Julie+L.+Daniels" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Daniels Julie L.%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Cuilin Zhang</button><span class='delimiter'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Cuilin Zhang </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">1</span>Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Cuilin+Zhang" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Zhang Cuilin%22">Google Scholar</a> </div> </div> </span> </span> <span class="al-author-name js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Neil J. Perkins</button><span class='delimiter-hidden'>, </span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Neil J. Perkins </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">1</span>Epidemiology Branch (S.L.M., E.F.S., A.J.G., C.Z., N.J.P.), Division of Epidemiology, Statistics, and Prevention Research, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Neil+J.+Perkins" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Perkins Neil J.%22">Google Scholar</a> </div> </div> </span> </span> <a class="meta-authors--etal is-active" id="show-meta-authors" aria-controls="remaining-authors" href="#"> <span>...</span> Show more </a> <div id="remaining-authors" class="meta-authors--remaining" aria-hidden="true" aria-labeledby="show-meta-authors"> <span class="al-author-name-more js-flyout-wrap"> <button type="button" class="linked-name js-linked-name-trigger btn-as-link">Jean Wactawski-Wende</button><span class='delimiter'></span> <span class="al-author-info-wrap arrow-up"> <div class="info-card-author authorInfo_OUP_Abstract_ArticleTop_Info_Widget"> <div class="name-role-wrap"> <div class="info-card-name"> Jean Wactawski-Wende </div> </div> <div class="info-card-affilitation"> <div class="aff"><span class="label title-label">4</span>Department of Social and Preventive Medicine (R.W.B., M.T., J.W.-W.), University at Buffalo, State University of New York, Buffalo, New York 14214;</div> </div> <div class="info-card-search-label"> Search for other works by this author on: </div> <div class="info-card-search info-card-search-internal"> <a href="/jcem/search-results?f_Authors=Jean+Wactawski-Wende" rel="nofollow">Oxford Academic</a> </div> <div class="info-card-search info-card-search-google"> <a href="http://scholar.google.com/scholar?q=author:%22Wactawski-Wende Jean%22">Google Scholar</a> </div> </div> </span> </span> </div> </div> </div> </div> <div class="pub-history-wrap clearfix js-history-dropdown-wrap"> <div class="pub-history-row clearfix"> <div class="ww-citation-primary"><em>The Journal of Clinical Endocrinology & Metabolism</em>, Volume 95, Issue 9, 1 September 2010, Pages E80–E85, <a href='https://doi.org/10.1210/jc.2010-0109'>https://doi.org/10.1210/jc.2010-0109</a></div> </div> <div class="pub-history-row clearfix"> <div class="ww-citation-date-wrap"> <div class="citation-label">Published:</div> <div class="citation-date">01 September 2010</div> </div> <a href="javascript:;" class="history-label js-history-dropdown-trigger st-article-history at-ArticleHistory"> <span>Article history</span><i class="icon-general-arrow-filled-down arrow-icon"></i> </a> </div> <div class="ww-history js-history-entries-wrap at-history-entries-wrap"> <div class="history-entry at-history-entry"> <div class="wi-state">Received:</div> <div class="wi-date">15 January 2010</div> </div> <div class="history-entry at-history-entry"> <div class="wi-state">Accepted:</div> <div class="wi-date">19 May 2010</div> </div> <div class="history-entry at-history-entry"> <div class="wi-state">Published:</div> <div class="wi-date">01 September 2010</div> </div> </div> </div> </div> </div> <script> $(document).ready(function () { $('.article-top-widget').on('click', '.ati-toggle-trigger', function () { $(this).find('.icon-general-add, .icon-minus').toggleClass('icon-minus icon-general-add'); $(this).siblings('.ati-toggle-content').toggleClass('hide'); }); // In Chrome, an anchor tag with target="_blank" and a "mailto:" href opens a new tab/window as well as the email client // I suspect this behavior will be corrected in the future // Remove the target="_blank" $('ul.wi-affiliationList').find('a[href^="mailto:"]').each(function () { $(this).removeAttr('target'); }); }); </script> </div> <div class="widget widget-ArticleLinks widget-instance-OUP_Article_Links_Widget"> </div> <div class="article-body js-content-body"> <div class="toolbar-wrap js-toolbar-wrap"> <div class="toolbar-inner-wrap"> <ul id="Toolbar" role="navigation"> <li class="toolbar-item item-with-dropdown item-views"> <a class="at-views-dropdown drop-trigger" href="javascript:;" data-dropdown="FilterDrop" aria-haspopup="true"> <i class="icon-menu_views"></i> <div class="toolbar-label"> <div class="toolbar-text">Views</div> <i class="icon-general-arrow-filled-down arrow-icon"></i> </div> </a> <ul id="ViewsDrop" class="f-dropdown js-dropdown-content" data-dropdown-content aria-label="submenu"> <div class="arrow-up"></div> <li class="article-content-filter js-article-content-filter" data-content-filter="article-content"> <a href="javascript:;"><span>Article contents</span></a> </li> <li class="at-figures-tables article-content-filter js-article-content-filter" data-content-filter="figures-tables"> <a href="javascript:;"><span>Figures & tables</span></a> </li> <li class="article-content-filter js-article-content-filter" data-content-filter="video"> <a href="javascript:;"><span>Video</span></a> </li> <li class="article-content-filter js-article-content-filter" data-content-filter="audio"> <a href="javascript:;"><span>Audio</span></a> </li> <li class="article-content-filter js-article-content-filter" data-content-filter="supplementary-data"> <a href="javascript:;"><span>Supplementary Data</span></a> </li> </ul> </li> <li class="toolbar-item item-cite js-item-cite"> <div class="widget widget-ToolboxGetCitation widget-instance-OUP_Get_Citation"> <a href="#" class="js-cite-button at-CiteButton" data-reveal-id="getCitation" data-reveal> <i class="icon-read-more"></i> <span>Cite</span> </a> <div id="getCitation" class="reveal-modal js-citation-modal" data-reveal> <h3 class="modal-title">Cite</h3> <div class="oxford-citation-text"> <p>Sunni L. Mumford, Enrique F. Schisterman, Anna Maria Siega-Riz, Richard W. Browne, Audrey J. Gaskins, Maurizio Trevisan, Anne Z. Steiner, Julie L. Daniels, Cuilin Zhang, Neil J. Perkins, Jean Wactawski-Wende, A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study, <em>The Journal of Clinical Endocrinology & Metabolism</em>, Volume 95, Issue 9, 1 September 2010, Pages E80–E85, <a href="https://doi.org/10.1210/jc.2010-0109">https://doi.org/10.1210/jc.2010-0109</a></p> </div> <div class="citation-download-wrap"> <form action="/Citation/Download" method="get" id="citationModal"> <input type="hidden" name="resourceId" value="2835175" /> <input type="hidden" name="resourceType" value="3" /> <label for="selectFormat" class="hide js-citation-format-label">Select Format</label> <select required name="citationFormat" class="citation-download-format js-citation-format" id="selectFormat"> <option selected disabled >Select format</option> <option value="0" >.ris (Mendeley, Papers, Zotero)</option> <option value="1" >.enw (EndNote)</option> <option value="2" >.bibtex (BibTex)</option> <option value="3" >.txt (Medlars, RefWorks)</option> </select> <button class="btn citation-download-link disabled" type="submit">Download citation</button> </form> </div> <a class="close-reveal-modal" href="javascript:;"><i class="icon-general-close"></i><span class="screenreader-text">Close</span></a> </div> </div> </li> <li class="toolbar-item item-tools"> <div class="widget widget-ToolboxPermissions widget-instance-OUP_Get_Permissions"> <div class="module-widget"> <a href="https://s100.copyright.com/AppDispatchServlet?publisherName=OUP&publication=1945-7197&title=A%20Longitudinal%20Study%20of%20Serum%20Lipoproteins%20in%20Relation%20to%20Endogenous%20Reproductive%20Hormones%20during%20the%20Menstrual%20Cycle%3A%20Findings%20from%20the%20BioCycle%20Study&publicationDate=2010-09-01&volumeNum=95&issueNum=9&author=Mumford%2C%20Sunni%20L.%3B%20Schisterman%2C%20Enrique%20F.&startPage=E80&endPage=E85&contentId=10.1210%2Fjc.2010-0109&oa=&copyright=Copyright%20%C2%A9%202010%20by%20The%20Endocrine%20Society&orderBeanReset=True" id="PermissionsLink" class="" target="_blank"> <i class="icon-menu_permissions"> <span class="screenreader-text">Permissions Icon</span> </i> Permissions </a> </div> </div> </li> <li class="toolbar-item item-with-dropdown item-share"> <a href="javascript:;" class="drop-trigger js-toolbar-dropdown at-ShareButton" data-dropdown="ShareDrop"> <i class="icon-menu_share"><span class="screenreader-text">Share Icon</span></i> <span class="toolbar-label"> <span class="toolbar-text">Share</span> <i class="arrow-icon icon-general-arrow-filled-down js-toolbar-arrow-icon"></i> </span> </a> <ul id="ShareDrop" class="addthis_toolbox addthis_default_style addthis_20x20_style f-dropdown js-dropdown-content" data-dropdown-content> <li> <a class="st-custom-button addthis_button_facebook js-share-link" data-network="facebook" data-title="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" data-url="https://academic.oup.com/jcem/article-abstract/95/9/E80/2835175" data-email-subject="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" href="javascript:;"><span>Facebook</span></a> </li> <li> <a class="st-custom-button addthis_button_twitter js-share-link" data-network="twitter" data-title="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" data-url="https://academic.oup.com/jcem/article-abstract/95/9/E80/2835175" data-email-subject="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" href="javascript:;"><span>Twitter</span></a> </li> <li> <a class="st-custom-button addthis_button_linkedin js-share-link" data-network="linkedin" data-title="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" data-url="https://academic.oup.com/jcem/article-abstract/95/9/E80/2835175" data-email-subject="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" href="javascript:;"><span>LinkedIn</span></a> </li> <li> <a class="st-custom-button addthis_button_email js-share-link" data-network="email" data-title="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" data-url="https://academic.oup.com/jcem/article-abstract/95/9/E80/2835175" data-email-subject="Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study" href="javascript:;"><span>Email</span></a> </li> </ul> </li> </ul> <div class="toolbar-search"> <div class="widget widget-SitePageHeader widget-instance-OUP_ArticleToolbarSearchBox"> <div class="dropdown-panel-wrap"> <div class="dropdown-panel mobile-search-dropdown"> <div class="mobile-search-inner-wrap"> <div class="navbar-search"> <div class="mobile-microsite-search"> <label for="OUP_ArticleToolbarSearchBox-mobile-navbar-search-filter" class="screenreader-text js-mobile-navbar-search-filter-label"> Navbar Search Filter </label> <select class="mobile-navbar-search-filter js-mobile-navbar-search-filter at-navbar-search-filter" id="OUP_ArticleToolbarSearchBox-mobile-navbar-search-filter"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="">The Journal of Clinical Endocrinology & Metabolism</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Issue">This issue</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Parent">Endocrine Society Journals</option> <optgroup class="navbar-search-optgroup" label="Search across Oxford Academic"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00160">Clinical Medicine</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00250">Endocrinology and Diabetes</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00010">Medicine and Health</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Books">Books</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Journals">Journals</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Umbrella">Oxford Academic</option> </optgroup> </select> <label for="OUP_ArticleToolbarSearchBox-mobile-microsite-search-term" class="screenreader-text js-mobile-microsite-search-term-label"> Mobile Enter search term </label> <input class="mobile-search-input mobile-microsite-search-term js-mobile-microsite-search-term at-microsite-search-term" type="text" maxlength="255" placeholder="Search" id="OUP_ArticleToolbarSearchBox-mobile-microsite-search-term"> <a href="javascript:;" class="mobile-microsite-search-icon mobile-search-submit icon-menu_search"> <span class="screenreader-text">Search</span> </a> </div> </div> </div> </div> <div class="dropdown-panel mobile-nav-dropdown"> </div> </div> <div class="navbar"> <div class="center-inner-row"> <nav class="navbar-menu"> </nav> <div class="navbar-search-container js-navbar-search-container"> <a href="javascript:;" class="navbar-search-close js_close-navsearch">Close</a> <div class="navbar-search"> <div class="microsite-search"> <label for="OUP_ArticleToolbarSearchBox-navbar-search-filter" class="screenreader-text js-navbar-search-filter-label"> Navbar Search Filter </label> <select class="navbar-search-filter js-navbar-search-filter at-navbar-search-filter" id="OUP_ArticleToolbarSearchBox-navbar-search-filter"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="">The Journal of Clinical Endocrinology & Metabolism</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Issue">This issue</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Parent">Endocrine Society Journals</option> <optgroup class="navbar-search-optgroup" label="Search across Oxford Academic"> <option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00160">Clinical Medicine</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00250">Endocrinology and Diabetes</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="AcademicSubjects/MED00010">Medicine and Health</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Books">Books</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Journals">Journals</option><option class="navbar-search-filter-option at-navbar-search-filter-option" value="Umbrella">Oxford Academic</option> </optgroup> </select> <label for="OUP_ArticleToolbarSearchBox-microsite-search-term" class="screenreader-text js-microsite-search-term-label"> Enter search term </label> <input class="navbar-search-input microsite-search-term js-microsite-search-term at-microsite-search-term" type="text" maxlength="255" placeholder="Search" id="OUP_ArticleToolbarSearchBox-microsite-search-term"> <a href="javascript:;" class="microsite-search-icon navbar-search-submit icon-menu_search"> <span class="screenreader-text">Search</span> </a> </div> </div> <div class="navbar-search-advanced"><a href="/jcem/advanced-search" class="advanced-search js-advanced-search">Advanced Search</a></div> </div> <div class="navbar-search-collapsed"><a href="javascript:;" class="icon-menu_search js_expand-navsearch"><span class="screenreader-text">Search Menu</span></a></div> </div> </div> <input id="routename" name="RouteName" type="hidden" value="jcem" /> </div> </div> </div> </div> <div id="ContentTab" class="content active"> <div class="widget widget-ArticleFulltext widget-instance-OUP_Abstract_Article_FullText_Widget"> <div class="module-widget"> <div class="widget-items" data-widgetname="ArticleFulltext"> <h2 scrollto-destination=59634305 id="59634305" class="abstract-title js-splitscreen-abstract-title" ></h2> <section class="abstract"><p class="chapter-para"><strong>Context:</strong> Exogenous estrogens have been shown to affect the lipid profile, leading to the hypothesis that endogenous estrogens may have similar effects.</p><p class="chapter-para"><strong>Objective:</strong> The objective of the study was to evaluate the association between endogenous estrogen and serum lipoproteins across the menstrual cycle.</p><p class="chapter-para"><strong>Design:</strong> This was a prospective cohort study.</p><p class="chapter-para"><strong>Setting:</strong> The study was conducted at the University at Buffalo, 2005–2007.</p><p class="chapter-para"><strong>Participants:</strong> Participants included 259 healthy, regularly menstruating women aged 18–44 yr.</p><p class="chapter-para"><strong>Main Outcome Measures:</strong> Serum levels of total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglycerides measured up to eight times per cycle for up to two cycles were measured.</p><p class="chapter-para"><strong>Results:</strong> Total and LDL cholesterol were lower during the luteal phase as compared with the follicular phase (<em>P</em> < 0.001), and HDL levels were highest around ovulation (<em>P</em> < 0.001). More women were classified above the desirable range (LDL ≥130 mg/dl or total cholesterol ≥200 mg/dl) when measured during the follicular phase. Estradiol was positively associated with HDL in acute effects models [beta = 0.019, 95% confidence interval (CI) 0.015, 0.022] and inversely associated with total (beta = −0.017, 95% CI −0.020, −0.014) and LDL cholesterol (beta = −0.023, 95% CI −0.027, −0.018) and triglycerides (beta = −0.041, 95% CI −0.054, −0.029) in persistent effects models.</p><p class="chapter-para"><strong>Conclusions:</strong> Endogenous estrogen, like exogenous estrogen, appears to have beneficial effects on the lipid profile. Because lipoprotein cholesterol levels vary across the menstrual cycle, cyclic variations in lipoprotein levels may need to be considered in the design and interpretation of studies in reproductive-age women and in the clinical management of women’s cholesterol.</p></section> <div class="article-metadata-panel clearfix at-ArticleMetadata"></div>  <div class="widget widget-ArticlePubStateInfo widget-instance-OUP_ArticlePubStateInfo"> </div> <div class="article-metadata-standalone-panel clearfix"></div> <div class="copyright copyright-statement">Copyright © 2010 by The Endocrine Society</div> <span id="UserHasAccess" data-userHasAccess="False"></span> </div> </div> </div> <div class="widget widget-SolrResourceMetadata widget-instance-OUP_Article_ResourceMetadata_Widget"> <div class="article-metadata-panel solr-resource-metadata js-metadata-panel at-ContentMetadata"> <div class="article-metadata-tocSections"> <div class="article-metadata-tocSections-title">Issue Section:</div> <a href="/jcem/search-results?f_TocHeadingTitleList=JCEM+Online%3a+Brief+Reports">JCEM Online: Brief Reports</a> </div> </div> </div> <div class="widget widget-EditorInformation widget-instance-OUP_Article_EditorInformation_Widget"> </div> <div id="no-access-message" class="article-top-info-user-restricted-options"> You do not currently have access to this article. </div> <div id="ContentTabFilteredView"></div> <div class="downloadImagesppt js-download-images-ppt st-download-images-ppt"> <a id="lnkDownloadAllImages" class="js-download-all-images-link btn" href="/DownloadFile/DownloadImage.aspx?image=&PPTtype=SlideSet&ar=2835175&xsltPath=~/UI/app/XSLT&siteId=5591">Download all slides</a> </div> <div class="widget widget-ArticleDataRepositories widget-instance-Article_DryadLink"> </div> <div class="comments"> <div class="widget widget-UserCommentBody widget-instance-UserCommentBody_Article"> </div> <div class="widget widget-UserComment widget-instance-OUP_UserComment_Article"> </div> </div> </div> </div> <div class="login-purchase-wrap"> <div id="article-purchase" class="unauth-row clearfix"> <div id="unauth" class="unauth-wrap"> <div class="widget widget-LoginBox widget-instance-LoginBox_UnAuthorizedLoginAndPaywall"> <div class="login-box" data-google-interstitial="false"> <div class="login-box__main-section-wrap"> <div class="login-box__section-wrap login-box_heading"> <div class="login-box__main-heading-wrap"> <h2>Sign in</h2> <a href="javascript:;" class="login-box__help js-login-help at-access-help"> <img class="login-box__help-icon" src="//oup.silverchair-cdn.com/UI/app/svg/i.svg" alt="Information" /> <span>Get help with access</span> </a> </div> </div> <div class="login-box__section-wrap login-box-society"> <div class="widget widget-SocietyLinks widget-instance-SocietyLinks"> <div class="login-form__section login-form__row--lower"> <ul class="society-links "> <li class="society-links-listing"> <a href="https://ams.endocrine.org/eweb/DynamicPage.aspx?Site=ES&webCode=TESOUP&ReturnURL=%node:current_encoded_url" class="society-links-logo"> <img src="//oup.silverchair-cdn.com/data/SiteBuilderAssetsOriginals/Live/Images/jcem/jcem_soc_auth1.svg" alt="Endocrine Society"/> </a> <div class="society-links-text"> <h3 class="login-form__heading">Endocrine Society members</h3> <a class="society-links-url button-call-to-action at-society-sign-in js-society-sign-in" href="https://ams.endocrine.org/eweb/DynamicPage.aspx?Site=ES&webCode=TESOUP&ReturnURL=%node:current_encoded_url"> <span>Sign in through society site</span> <img class="society-link-icon" src="//oup.silverchair-cdn.com/UI/app/svg/chevron-right-white.svg" alt="Arrow" aria-hidden="true"/> </a> </div> </li> </ul> </div> <input id="hfPlaceholderReturnUrlValue" name="hfPlaceholderReturnUrlValue" type="hidden" value="%node:current_encoded_url" /> </div> </div> <div class="login-box__section-wrap cols login-box_sign-in-accounts"> <div class="login-box__section column-border login-box_personal-account"> <h3 class="login-box__heading">Personal account</h3> <ul class="bullets"> <li>Sign in with email/username & password</li> <li>Get email alerts</li> <li>Save searches</li> <li>Purchase content</li> <li>Activate your purchase/trial code</li> <li>Add your ORCID iD</li> </ul> <div class="login-box__button-row"> <a rel="nofollow" class="button-call-to-action at-personal-sign-in js-sign-in-link" data-linkType="user-pass" href="javascript:;"> <span>Sign in</span> <img class="society-link-icon" src="//oup.silverchair-cdn.com/UI/app/svg/chevron-right-white.svg" alt="Arrow" aria-hidden="true"/> </a> <a rel="nofollow" class="at-personal-register-link js-register-link" href="/my-account/register?siteId=5591&returnUrl=http%3a%2f%2facademic.oup.com%2fjcem%2farticle-abstract%2f95%2f9%2fE80%2f2835175%3fredirectedFrom%3dfulltext">Register</a> </div> </div> <div class="login-box__section column-border login-box_institution"> <h3 class="login-box__heading">Institutional access</h3> <ol> <div class="widget widget-SeamlessAccess widget-instance-LoginBoxInstitutionalAccount"> <a href="javascript:;" class="login-box__sign-in-link js-shibboleth-action seamless-access-button seamless-button-login-box button-call-to-action at-institutional-sign-in" rel="nofollow" data-action-type="" data-entity-id=""> <span class="seamless-access-text">Sign in through your institution</span> </a> <div> <a href="javascript:;" class="login-box__sign-in-link js-shibboleth-action change-institution" rel="nofollow" data-action-type=""> Sign in through your institution </a> </div> </div> <li class="login-box__button-row"> <a rel="nofollow" class="login-box__sign-in-link js-sign-in-link" data-linkType="library-card" href="javascript:;">Sign in with a library card</a> </li> <li class="login-box__button-row"> <a rel="nofollow" class="login-box__sign-in-link js-sign-in-link at-institutional-sign-in-username" data-linkType="user-pass" href="javascript:;">Sign in with username/password</a> </li> <li class="login-box__button-row"> <a rel="nofollow" class="login-box__sign-in-link js-sign-in-link at-institutional-recommend" href="/pages/get-help-with-access/recommend-to-your-librarian?journal=jcem">Recommend to your librarian</a> </li> </ol> <h3 class="login-box__heading login-box__administrator_heading at-administrator-heading">Institutional account management</h3> <a rel="nofollow" class="login-box__sign-in-link js-sign-in-link" href="javascript:" data-linkType="user-pass">Sign in as administrator</a> </div> </div> <div id="divAccessHelp" class="accessHelp-modal small reveal-modal" data-reveal> <div tabindex="0" id="AccessHelpContainer" class="comment-form__wrap" data-reveal> <h2>Get help with access</h2> <h3>Institutional access</h3> <p> Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways: </p> <h4>IP based access</h4> <p> Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. </p> <h4>Sign in through your institution</h4> <p> Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institutionâ€™s website and Oxford Academic. </p> <ol class="order"> <li>Click Sign in through your institution.</li> <li>Select your institution from the list provided, which will take you to your institution's website to sign in.</li> <li>When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.</li> <li>Following successful sign in, you will be returned to Oxford Academic.</li> </ol> <p> If your institution is not listed or you cannot sign in to your institutionâ€™s website, please contact your librarian or administrator. </p> <h4>Sign in with a library card</h4> <p> Enter your library card number to sign in. If you cannot sign in, please contact your librarian. </p> <h3>Society Members</h3> <p> Society member access to a journal is achieved in one of the following ways: </p> <h4>Sign in through society site</h4> <p> Many societies offer single sign-on between the society website and Oxford Academic. If you see â€˜Sign in through society siteâ€™ in the sign in pane within a journal: </p> <ol class="order"> <li>Click Sign in through society site.</li> <li>When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.</li> <li>Following successful sign in, you will be returned to Oxford Academic.</li> </ol> <p> If you do not have a society account or have forgotten your username or password, please contact your society. </p> <h4>Sign in using a personal account</h4> <p> Some societies use Oxford Academic personal accounts to provide access to their members. See below. </p> <h3>Personal account</h3> <p> A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions. </p> <p> Some societies use Oxford Academic personal accounts to provide access to their members. </p> <h3>Viewing your signed in accounts</h3> <p> Click the account icon in the top right to: </p> <ul> <li>View your signed in personal account and access account management features.</li> <li>View the institutional accounts that are providing access.</li> </ul> <h3>Signed in but can't access content</h3> <p> Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian. </p> <h3>Institutional account management</h3> <p> For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more. </p> </div> <button class="accessHelp__close btn-as-icon icon-general-close js-access-help-close"> <span class="screenreader-text">Close access help modal</span> </button> </div> </div> </div> </div> </div> <div class="widget widget-PurchaseOptions widget-instance-OUP_ArticlePage_PurchaseOptions"> <div class="purchase-wrap"> <h2 class="purchase-title">Purchase</h2> <div> <a class="purchase-subscription-links" href="/jcem/Subscribe/CurrentYear">Subscription prices and ordering for this journal</a> </div> <div> <a class="purchase-subscription-link" href="/pages/purchasing">Purchasing options for books and journals across Oxford Academic</a> </div> <div class="purchase-ppv-wrap-article clearfix"> <h3>Short-term Access</h3> <div class="register-ribbon-wrap"> <p> To purchase short-term access, please sign in to your personal account above. </p> <p> Don't already have a personal account? <a class="at-ShortTermAccess-Register" href="https://academic.oup.com/my-account/register?siteId=5591&returnUrl=https://academic.oup.com%2fjcem%2farticle-abstract%2f95%2f9%2fE80%2f2835175%3fredirectedFrom%3dfulltext">Register</a> </p> </div> A Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study - 24 Hours access <div class="purchase-currency-wrap"> <div class="purchase-currency"> EUR €38.00 </div> <div class="purchase-currency"> GBP £33.00 </div> <div class="purchase-currency"> USD $41.00 </div> </div> </div> </div> <div id="divDeepDive" class="deep-dive-wrap js-deepdyve-link" data-issn="0021972X" data-eissn="19457197" data-doi="10.1210/jc.2010-0109" data-fieldname="journal_doi" data-affiliate="OUP"> <h3 class="deep-dive-title">Rental</h3> <div class="deep-dive-box"> <div class="deep-dive-img"> <a class="deepDiveLink" href="https://www.deepdyve.com/doc-view?docId=10.1210/jc.2010-0109&fieldName=journal_doi&affiliateId=OUP" target="_blank"><img src="https://www.deepdyve.com/assets/images/deepdyve-link-button.svg" style="border:none" alt="Read this now at DeepDyve" /></a> </div> <div class="deep-dive-text"> This article is also available for rental through DeepDyve. </div> </div> </div> </div> </div> </div> </div> </div> <div id="Sidebar" class="page-column page-column--right"> <div class="widget widget-AdBlock widget-instance-ArticlePageTopSidebar"> <div class="js-adBlock-parent-wrap adblock-parent-wrap"> <div class="adBlockMainBodyTop-wrap js-adBlockMainBodyTop hide"> <div id="adBlockMainBodyTop" class="js-adblock at-adblock" data-lazy-load-margin="150"> <script> googletag.cmd.push(function () { googletag.display('adBlockMainBodyTop'); }); </script> </div> <div class="advertisement-text at-adblock js-adblock-advertisement-text hide">Advertisement</div> </div> </div> </div> <div class="widget widget-dynamic " data-count="1"> <div class="widget-dynamic-inner-wrap"> <div class="widget widget-dynamic " data-count="10"> <div class="widget-dynamic-inner-wrap"> <div class="widget widget-ArticleLevelMetrics widget-instance-Article_RightRailB0Article_RightRail_ArticleLevelMetrics"> <div class="artmet-wrapper horizontal-artmet"> <div class="contentmet-border"> <div class="contentmet-wrapper horizontal-contentmet"> <div class="contentmet-citations contentmet-badges-wrap js-contentmet-citations hide"> <h3 class="contentmet-text">Citations</h3> <div class="contentmet-item contentmet-dimensions"> <div class="widget widget-DimensionsBadge widget-instance-ArticleLevelMetrics_DimensionsBadge"> <span class="__dimensions_badge_embed__" data-doi="10.1210/jc.2010-0109" data-legend="never" data-style="small_circle" data-hide-zero-citations="false"></span> <script async src="https://badge.dimensions.ai/badge.js" charset="utf-8"></script> </div> </div> </div> <div class="contentmet-views contentmet-badges-wrap js-contentmet-views"> <h3 class="contentmet-text">Views</h3> <div class="contentmet-item circle-text circle-text-views"> <div class="contentmet-number">1,478</div> </div> </div> <div class="contentmet-item contentmet-badges-wrap"> <h3 class="contentmet-text">Altmetric</h3> <div class="contentmet-item contentmet-altmetric"> <div class="widget widget-AltmetricLink widget-instance-ArticleLevelMetrics_AltmetricLinkSummary">  <div id="altmetricEmbedId" runat="server" class='altmetric-embed' data-badge-type="donut" data-hide-no-mentions="false" data-doi="10.1210/jc.2010-0109" ></div> <script type='text/javascript' src='https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js'></script> </div> </div> </div> <div class="contentmet-modal-trigger-wrap clearfix"> <a href="javascript:;" class="artmet-modal-trigger js-artmet-modal-trigger at-alm-metrics-modal-trigger" data-resource-id="2835175" data-resource-type="3"> <img class="contentmet-info-icon" src="//oup.silverchair-cdn.com/UI/app/svg/i.svg" alt="Information"> <span class="contentmet-more-info">More metrics information</span> </a> </div> </div> </div> <div class="artmet-modal js-artmet-modal" id="MetricsModal"> <div class="artmet-modal-contents js-metric-modal-contents at-alm-modal-contents"> <div class="artmet-full-wrap clearfix js-metric-full-wrap hide"> <div class="widget-title-1 artmet-widget-title-1">Metrics</div> <div class="artmet-item artmet-views-wrap"> <div class="artmet-views clearfix"> <div class="artmet-total-views"> <span class="artmet-text">Total Views</span> <span class="artmet-number">1,478</span> </div> <div class="artmet-breakdown-views-wrap"> <div class="artmet-breakdown-view breakdown-border"> <span class="artmet-number">1,015</span> <span class="artmet-text">Pageviews</span> </div> <div class="artmet-breakdown-view"> <span class="artmet-number">463</span> <span class="artmet-text">PDF Downloads</span> </div> </div> </div> <div class="artmet-views-since">Since 1/1/2017</div> </div> <script> var ChartistData = ChartistData || {}; ChartistData.data = { labels: ['Jan 2017', 'Feb 2017', 'Mar 2017', 'Apr 2017', 'May 2017', 'Jun 2017', 'Sep 2017', 'Oct 2017', 'Nov 2017', 'Dec 2017', 'Jan 2018', 'Feb 2018', 'Mar 2018', 'Apr 2018', 'May 2018', 'Jun 2018', 'Jul 2018', 'Aug 2018', 'Sep 2018', 'Oct 2018', 'Nov 2018', 'Dec 2018', 'Jan 2019', 'Feb 2019', 'Mar 2019', 'Apr 2019', 'May 2019', 'Jun 2019', 'Jul 2019', 'Aug 2019', 'Sep 2019', 'Oct 2019', 'Nov 2019', 'Dec 2019', 'Jan 2020', 'Feb 2020', 'Mar 2020', 'Apr 2020', 'May 2020', 'Jun 2020', 'Jul 2020', 'Aug 2020', 'Sep 2020', 'Oct 2020', 'Nov 2020', 'Dec 2020', 'Jan 2021', 'Feb 2021', 'Mar 2021', 'Apr 2021', 'May 2021', 'Jun 2021', 'Jul 2021', 'Aug 2021', 'Sep 2021', 'Oct 2021', 'Nov 2021', 'Dec 2021', 'Jan 2022', 'Feb 2022', 'Mar 2022', 'Apr 2022', 'May 2022', 'Jun 2022', 'Jul 2022', 'Aug 2022', 'Sep 2022', 'Oct 2022', 'Nov 2022', 'Dec 2022', 'Jan 2023', 'Feb 2023', 'Mar 2023', 'Apr 2023', 'May 2023', 'Jun 2023', 'Jul 2023', 'Aug 2023', 'Sep 2023', 'Oct 2023', 'Nov 2023', 'Dec 2023', 'Jan 2024', 'Feb 2024', 'Mar 2024', 'Apr 2024', 'May 2024', 'Jun 2024', 'Jul 2024', 'Aug 2024', 'Sep 2024', 'Oct 2024', 'Nov 2024'], series: [[3, 4, 1, 2, 4, 2, 6, 16, 10, 9, 8, 9, 13, 21, 10, 22, 20, 7, 10, 17, 17, 13, 17, 27, 28, 25, 19, 21, 26, 23, 43, 23, 12, 8, 18, 15, 21, 8, 8, 17, 8, 8, 12, 13, 14, 6, 10, 19, 16, 26, 15, 5, 11, 17, 14, 11, 10, 12, 12, 2, 7, 12, 11, 29, 26, 17, 23, 23, 22, 5, 27, 21, 16, 25, 19, 7, 11, 12, 26, 14, 30, 12, 27, 25, 31, 31, 25, 27, 25, 28, 20, 9, 11]] }; </script> <div class="artmet-item artmet-chart"> <div class="ct-chart ct-octave js-ct-chart"></div> <div class="artmet-table"> <table> <thead> <tr> <th>Month:</th> <th>Total Views:</th> </tr> </thead> <tbody> <tr> <td>January 2017</td> <td>3</td> </tr> <tr> <td>February 2017</td> <td>4</td> </tr> <tr> <td>March 2017</td> <td>1</td> </tr> <tr> <td>April 2017</td> <td>2</td> </tr> <tr> <td>May 2017</td> <td>4</td> </tr> <tr> <td>June 2017</td> <td>2</td> </tr> <tr> <td>September 2017</td> <td>6</td> </tr> <tr> <td>October 2017</td> <td>16</td> </tr> <tr> <td>November 2017</td> <td>10</td> </tr> <tr> <td>December 2017</td> <td>9</td> </tr> <tr> <td>January 2018</td> <td>8</td> </tr> <tr> <td>February 2018</td> <td>9</td> </tr> <tr> <td>March 2018</td> <td>13</td> </tr> <tr> <td>April 2018</td> <td>21</td> </tr> <tr> <td>May 2018</td> <td>10</td> </tr> <tr> <td>June 2018</td> <td>22</td> </tr> <tr> <td>July 2018</td> <td>20</td> </tr> <tr> <td>August 2018</td> <td>7</td> </tr> <tr> <td>September 2018</td> <td>10</td> </tr> <tr> <td>October 2018</td> <td>17</td> </tr> <tr> <td>November 2018</td> <td>17</td> </tr> <tr> <td>December 2018</td> <td>13</td> </tr> <tr> <td>January 2019</td> <td>17</td> </tr> <tr> <td>February 2019</td> <td>27</td> </tr> <tr> <td>March 2019</td> <td>28</td> </tr> <tr> <td>April 2019</td> <td>25</td> </tr> <tr> <td>May 2019</td> <td>19</td> </tr> <tr> <td>June 2019</td> <td>21</td> </tr> <tr> <td>July 2019</td> <td>26</td> </tr> <tr> <td>August 2019</td> <td>23</td> </tr> <tr> <td>September 2019</td> <td>43</td> </tr> <tr> <td>October 2019</td> <td>23</td> </tr> <tr> <td>November 2019</td> <td>12</td> </tr> <tr> <td>December 2019</td> <td>8</td> </tr> <tr> <td>January 2020</td> <td>18</td> </tr> <tr> <td>February 2020</td> <td>15</td> </tr> <tr> <td>March 2020</td> <td>21</td> </tr> <tr> <td>April 2020</td> <td>8</td> </tr> <tr> <td>May 2020</td> <td>8</td> </tr> <tr> <td>June 2020</td> <td>17</td> </tr> <tr> <td>July 2020</td> <td>8</td> </tr> <tr> <td>August 2020</td> <td>8</td> </tr> <tr> <td>September 2020</td> <td>12</td> </tr> <tr> <td>October 2020</td> <td>13</td> </tr> <tr> <td>November 2020</td> <td>14</td> </tr> <tr> <td>December 2020</td> <td>6</td> </tr> <tr> <td>January 2021</td> <td>10</td> </tr> <tr> <td>February 2021</td> <td>19</td> </tr> <tr> <td>March 2021</td> <td>16</td> </tr> <tr> <td>April 2021</td> <td>26</td> </tr> <tr> <td>May 2021</td> <td>15</td> </tr> <tr> <td>June 2021</td> <td>5</td> </tr> <tr> <td>July 2021</td> <td>11</td> </tr> <tr> <td>August 2021</td> <td>17</td> </tr> <tr> <td>September 2021</td> <td>14</td> </tr> <tr> <td>October 2021</td> <td>11</td> </tr> <tr> <td>November 2021</td> <td>10</td> </tr> <tr> <td>December 2021</td> <td>12</td> </tr> <tr> <td>January 2022</td> <td>12</td> </tr> <tr> <td>February 2022</td> <td>2</td> </tr> <tr> <td>March 2022</td> <td>7</td> </tr> <tr> <td>April 2022</td> <td>12</td> </tr> <tr> <td>May 2022</td> <td>11</td> </tr> <tr> <td>June 2022</td> <td>29</td> </tr> <tr> <td>July 2022</td> <td>26</td> </tr> <tr> <td>August 2022</td> <td>17</td> </tr> <tr> <td>September 2022</td> <td>23</td> </tr> <tr> <td>October 2022</td> <td>23</td> </tr> <tr> <td>November 2022</td> <td>22</td> </tr> <tr> <td>December 2022</td> <td>5</td> </tr> <tr> <td>January 2023</td> <td>27</td> </tr> <tr> <td>February 2023</td> <td>21</td> </tr> <tr> <td>March 2023</td> <td>16</td> </tr> <tr> <td>April 2023</td> <td>25</td> </tr> <tr> <td>May 2023</td> <td>19</td> </tr> <tr> <td>June 2023</td> <td>7</td> </tr> <tr> <td>July 2023</td> <td>11</td> </tr> <tr> <td>August 2023</td> <td>12</td> </tr> <tr> <td>September 2023</td> <td>26</td> </tr> <tr> <td>October 2023</td> <td>14</td> </tr> <tr> <td>November 2023</td> <td>30</td> </tr> <tr> <td>December 2023</td> <td>12</td> </tr> <tr> <td>January 2024</td> <td>27</td> </tr> <tr> <td>February 2024</td> <td>25</td> </tr> <tr> <td>March 2024</td> <td>31</td> </tr> <tr> <td>April 2024</td> <td>31</td> </tr> <tr> <td>May 2024</td> <td>25</td> </tr> <tr> <td>June 2024</td> <td>27</td> </tr> <tr> <td>July 2024</td> <td>25</td> </tr> <tr> <td>August 2024</td> <td>28</td> </tr> <tr> <td>September 2024</td> <td>20</td> </tr> <tr> <td>October 2024</td> <td>9</td> </tr> <tr> <td>November 2024</td> <td>11</td> </tr> </tbody> </table> </div> </div> <div class="artmet-stats-wrap clearfix"> <div class="artmet-item artmet-citations hide"> <div class="widget-title-2 artmet-widget-title-2">Citations</div> <div class="artmet-badges-wrap artmet-dimensions"> <div class="widget widget-DimensionsBadge widget-instance-ArticleLevelMetrics_DimensionsBadgeDetails"> <span class="__dimensions_badge_embed__" data-doi="10.1210/jc.2010-0109" data-legend="always" data-style="" data-hide-zero-citations="false"></span> <script async src="https://badge.dimensions.ai/badge.js" charset="utf-8"></script> </div> <span class="artmet-dimensions-text">Powered by Dimensions</span> </div> <div class="artmet-wos"> <span class="artmet-number"> <a href="https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=silverchair&SrcAuth=WosAPI&KeyUT=WOS:000281640300014&DestLinkType=CitingArticles&DestApp=WOS_CPL" target="_blank">60</a> </span> <span class="artmet-text">Web of Science</span> </div> </div> <div class="artmet-item artmet-altmetric js-show-if-unknown"> <div class="widget-title-2 artmet-widget-title-2">Altmetrics</div> <div class="artmet-badges-wrap js-artmet-badges"> <div class="widget widget-AltmetricLink widget-instance-ArticleLevelMetrics_AltmetricLinkDetails">  <div id="altmetricEmbedId" runat="server" class='altmetric-embed' data-badge-type="donut" data-hide-no-mentions="false" data-doi="10.1210/jc.2010-0109" data-badge-details = "right" ></div> <script type='text/javascript' src='https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js'></script> </div> </div> </div> </div> </div> <a class="artmet-close-modal js-artmet-close-modal">×</a> </div> </div> </div> </div> <div class="widget widget-Alerts widget-instance-Article_RightRailB0Article_RightRail_Alerts"> <div class="alertsWidget"> <h3>Email alerts</h3> <div class="userAlert alertType-1"> <a href="javascript:;" class="js-user-alert" role="button" data-userLoggedIn="False" data-alertType="1" href="javascript:;">Article activity alert</a> </div> <div class="userAlert alertType-3"> <a href="javascript:;" class="js-user-alert" role="button" data-userLoggedIn="False" data-alertType="3" href="javascript:;">Advance article alerts</a> </div> <div class="userAlert alertType-5"> <a href="javascript:;" class="js-user-alert" role="button" data-userLoggedIn="False" data-alertType="5" href="javascript:;">New issue alert</a> </div> <div class="userAlert alertType-MarketingLink"> <a href="javascript:;" class="js-user-alert" role="button" data-userLoggedIn="False" data-additionalUrl="/my-account/communication-preferences" href="javascript:;">Receive exclusive offers and updates from Oxford Academic</a> </div> <div class="userAlertSignUpModal reveal-modal small" data-reveal> <div class="userAlertSignUp at-userAlertSignUp"></div> <a href="javascript:;" role="button" aria-label="Close" class="close-reveal-modal" href="javascript:;"> <i class="icon-general-close"></i> </a> </div> </div> </div> <div class="widget widget-TrendMD widget-instance-Article_RightRailB0trendmd"> <div id="trendmd-suggestions"></div> <div class="options" data-suppress-if-hum-is-present="True"></div> </div> <div class="widget widget-RelatedContent widget-instance-Article_RightRailB0Article_RightRail_RelatedContent"> <h3 class="article-widget-head">More on this topic</h3> <div class="widget-related-content at-related-content"> <div class="article-title"><a href="/jcem/article/91/11/4433/2656585">Circulating Estradiol Is an Independent Predictor of Progression of Carotid Artery Intima-Media Thickness in Middle-Aged Men</a></div> <div class="article-title"><a href="/jcem/article/67/1/36/2653873">Dose-Response Studies With Biosynthetic Human Growth Hormone (GH) in GH-Deficient Patients</a></div> <div class="article-title"><a href="/jcem/article/15/1/73/2718906">EFFECT OF LONG-TERM ADMINISTRATION OF DESICCATED THYROID ON SERUM LIPOPROTEIN AND CHOLESTEROL LEVELS</a></div> <div class="article-title"><a href="/jcem/article/91/1/176/2843378"><em>Helicobacter pylori</em> Infection and Autoimmune Thyroid Disease in Young Patients: The Disadvantage of Carrying the Human Leukocyte Antigen-DRB1*0301 Allele</a></div> </div> </div> <div class="widget widget-RelatedPubMed widget-instance-Article_RightRailB0Article_RightRail_RelatedPubMed"> <h3 class="article-widget-head">Related articles in PubMed</h3> <div class="widget-related-pubmed"> <div class="inner-content-wrap"> <div class="inner-content"> <div class="article-title"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/39551948" id="article_ArticleTitle" target="_blank">Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis.</a></div>  </div> </div> <div class="inner-content-wrap"> <div class="inner-content"> <div class="article-title"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/39551811" id="article_ArticleTitle" target="_blank">Cleistopholis patens root bark extract exerts cardioprotective effect against doxorubicin-induced myocardial toxicity in rats.</a></div>  </div> </div> <div class="inner-content-wrap"> <div class="inner-content"> <div class="article-title"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/39551681" id="article_ArticleTitle" target="_blank">HDL and cardiovascular risk.</a></div>  </div> </div> <div class="inner-content-wrap"> <div class="inner-content"> <div class="article-title"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/39551491" id="article_ArticleTitle" target="_blank">Non-high-density Lipoprotein Cholesterol for Secondary Prevention after Minor Stroke.</a></div>  </div> </div> </div>  </div> <div class="widget widget-ArticleCitedBy widget-instance-Article_RightRailB0Article_RightRail_ArticleCitedBy"> <div class="rail-widget_wrap vt-articles-cited-by"> <h3 class="article-cited-title">Citing articles via</h3> <div class="widget-links_wrap"> <div class="article-cited-link-wrap web-of-science"> <a href="https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=silverchair&SrcAuth=WosAPI&KeyUT=WOS:000281640300014&DestLinkType=CitingArticles&DestApp=WOS_CPL" target="_blank">Web of Science (60)</a> </div> <div class="article-cited-link-wrap google-scholar-url"> <a href="http://scholar.google.com/scholar?q=link:https%3A%2F%2Facademic.oup.com%2Fjcem%2Farticle%2F95%2F9%2FE80%2F2835175" target="_blank">Google Scholar</a> </div> </div> </div> </div> <div class="widget widget-ArticleListNewAndPopular widget-instance-Article_RightRailB0Article_RightRail_ArticleNewPopularCombined"> <ul class="articleListNewAndPopularCombinedView"> <li> <h3> <a href="javascript:;" class="articleListNewAndPopular-mode active" data-mode="MostRecent">Latest</a> </h3> </li> <li> <h3> <a href="javascript:;" class="articleListNewAndPopular-mode " data-mode="MostRead">Most Read</a> </h3> </li> <li> <h3> <a href="javascript:;" class="articleListNewAndPopular-mode " data-mode="MostCited">Most Cited</a> </h3> </li> </ul> <section class="articleListNewPopContent articleListNewAndPopular-ContentView-MostRecent hasContent"> <div id="newPopularList-Article_RightRailB0Article_RightRail_ArticleNewPopularCombined" class="fb"> <div class="widget-layout widget-layout--vert "> <div class="widget-columns widget-col-1"> <div class="col"> <div class="widget-dynamic-entry journalArticleItem at-widget-entry-SCL"> <span class="hfDoi" data-attribute="10.1210/clinem/dgae731" aria-hidden="true"></span> <a class="journal-link" href="/jcem/advance-article/doi/10.1210/clinem/dgae731/7906878?searchresult=1"> <div class="widget-dynamic-journal-title"> Cushing-induced Male Hypogonadism: Deciphering a Prevalent Yet Understudied Relationship </div> </a> <div class="widget-dynamic-journal-image-synopsis"> <div class="widget-dynamic-journal-synopsis"> </div> </div> </div> <div class="widget-dynamic-entry journalArticleItem at-widget-entry-SCL"> <span class="hfDoi" data-attribute="10.1210/clinem/dgae815" aria-hidden="true"></span> <a class="journal-link" href="/jcem/advance-article/doi/10.1210/clinem/dgae815/7906731?searchresult=1"> <div class="widget-dynamic-journal-title"> Disordered electron transfer: New forms of defective steroidogenesis and mitochondriopathy </div> </a> <div class="widget-dynamic-journal-image-synopsis"> <div class="widget-dynamic-journal-synopsis"> </div> </div> </div> <div class="widget-dynamic-entry journalArticleItem at-widget-entry-SCL"> <span class="hfDoi" data-attribute="10.1210/clinem/dgae808" aria-hidden="true"></span> <a class="journal-link" href="/jcem/advance-article/doi/10.1210/clinem/dgae808/7906730?searchresult=1"> <div class="widget-dynamic-journal-title"> MBX 2109, a Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug: Phase 1, First-in-Human, Randomized Trial </div> </a> <div class="widget-dynamic-journal-image-synopsis"> <div class="widget-dynamic-journal-synopsis"> </div> </div> </div> <div class="widget-dynamic-entry journalArticleItem at-widget-entry-SCL"> <span class="hfDoi" data-attribute="10.1210/clinem/dgae813" aria-hidden="true"></span> <a class="journal-link" href="/jcem/advance-article/doi/10.1210/clinem/dgae813/7906046?searchresult=1"> <div class="widget-dynamic-journal-title"> Genetic and Clinical Characteristics of 185 Japanese Children with 46,XY Differences of Sex Development </div> </a> <div class="widget-dynamic-journal-image-synopsis"> <div class="widget-dynamic-journal-synopsis"> </div> </div> </div> <div class="widget-dynamic-entry journalArticleItem at-widget-entry-SCL"> <span class="hfDoi" data-attribute="10.1210/clinem/dgae814" aria-hidden="true"></span> <a class="journal-link" href="/jcem/advance-article/doi/10.1210/clinem/dgae814/7905809?searchresult=1"> <div class="widget-dynamic-journal-title"> Growth Hormone Therapy in Chronic Heart Failure: a Systematic Review and Meta-Analysis of Randomized Controlled Trials </div> </a> <div class="widget-dynamic-journal-image-synopsis"> <div class="widget-dynamic-journal-synopsis"> </div> </div> </div> </div> </div> </div></div> </section> <section class="articleListNewPopContent articleListNewAndPopular-ContentView-MostRead hide"> </section> <section class="articleListNewPopContent articleListNewAndPopular-ContentView-MostCited hide"> </section> </div> <div class="widget widget-RelatedTaxonomies widget-instance-Article_RightRailB0Article_RightRail_RelatedTaxonomies"> <div class="widget-related-taxonomies-wrap vt-related-taxonomies"> <div class="widget-related-taxonomies_title">More from Oxford Academic</div> <div class="widget-related-taxonomies"> <a id="more-from-oa-AcademicSubjects_MED00160" class="related-taxonomies-link" href="/search-results?tax=AcademicSubjects/MED00160">Clinical Medicine</a> </div> <div class="widget-related-taxonomies"> <a id="more-from-oa-AcademicSubjects_MED00250" class="related-taxonomies-link" href="/search-results?tax=AcademicSubjects/MED00250">Endocrinology and Diabetes</a> </div> <div class="widget-related-taxonomies"> <a id="more-from-oa-AcademicSubjects_MED00010" class="related-taxonomies-link" href="/search-results?tax=AcademicSubjects/MED00010">Medicine and Health</a> </div> <div class="widget-related-taxonomies"> <a id="more-from-oa-format-Books" class="related-taxonomies-link" href="/books">Books</a> </div> <div class="widget-related-taxonomies"> <a id="more-from-oa-format-Journals" class="related-taxonomies-link" href="/journals">Journals</a> </div> </div> </div> </div> </div> </div> </div> <div class="widget widget-AdBlock widget-instance-ArticlePageTopMainBodyBottom"> <div class="js-adBlock-parent-wrap adblock-parent-wrap"> <div class="adBlockMainBodyBottom-wrap js-adBlockMainBodyBottom hide"> <div id="adBlockMainBodyBottom" class="js-adblock at-adblock js-adblock-lazy-loading" data-lazy-load-margin="150"> <script> googletag.cmd.push(function () { googletag.display('adBlockMainBodyBottom'); }); </script> </div> <div class="advertisement-text at-adblock js-adblock-advertisement-text hide">Advertisement</div> </div> </div> </div> </div> </div> <input id="hfArticleTitle" name="hfArticleTitle" type="hidden" value="" /> <input id="hfLeftNavStickyOffset" name="hfLeftNavStickyOffset" type="hidden" value="29" /> </div> </section> </div> <div class="mobile-mask"> </div> <section class="footer_wrap vt-site-footer"> <div class="ad-banner-footer sticky-footer-ad js-sticky-footer-ad"> <div class="widget widget-AdBlock widget-instance-StickyFooterAd"> <div class="js-adBlock-parent-wrap adblock-parent-wrap"> <div class="adBlockStickyFooter-wrap js-adBlockStickyFooter hide"> <div id="adBlockStickyFooter" class="js-adblock at-adblock" data-lazy-load-margin="150"> <script> googletag.cmd.push(function () { googletag.display('adBlockStickyFooter'); }); </script> </div> <div class="advertisement-text at-adblock js-adblock-advertisement-text hide">Advertisement</div> <button type="button" class="close-footer-ad js-close-footer-ad"> <span class="screenreader-text">close advertisement</span> </button> </div> </div> </div> </div> <div class="widget widget-SitePageFooter widget-instance-SitePageFooter"> <div class="ad-banner ad-banner-footer"> <div class="widget widget-AdBlock widget-instance-FooterAd"> <div class="js-adBlock-parent-wrap adblock-parent-wrap"> <div class="adBlockFooter-wrap js-adBlockFooter hide"> <div id="adBlockFooter" class="js-adblock at-adblock js-adblock-lazy-loading" data-lazy-load-margin="150"> <script> googletag.cmd.push(function () { googletag.display('adBlockFooter'); }); </script> </div> <div class="advertisement-text at-adblock js-adblock-advertisement-text hide">Advertisement</div> </div> </div> </div> </div> <div class="journal-footer journal-bg"> <div class="center-inner-row"> <div class="journal-footer-menu"> <ul> <li class="link-1"> <a href="/jcem/pages/About">About The Journal of Clinical Endocrinology & Metabolism</a> </li> <li class="link-2"> <a href="https://www.endocrine.org/about-us">About the Endocrine Society</a> </li> <li class="link-3"> <a href="/jcem/pages/Editorial_Board">Editorial Board</a> </li> <li class="link-4"> <a href="/jcem/pages/Author_Guidelines">Author Guidelines</a> </li> <li class="link-5"> <a href="http://www.endocrine.org/about-us/contacts-and-directions">Contact Us</a> </li> </ul><ul><li class="link-1"> <a href="https://www.facebook.com/EndocrineSociety">Facebook</a> </li> <li class="link-2"> <a href="https://www.linkedin.com/company/the-endocrine-society/">LinkedIn</a> </li> <li class="link-3"> <a href="/jcem/subscribe">Purchase</a> </li> <li class="link-4"> <a href="http://www.oxfordjournals.org/en/library-recommendation-form.html">Recommend to Your Librarian</a> </li> <li class="link-5"> <a href="http://www.endocrine.org/corporate-relations/print-and-online-advertising">Advertising and Corporate Services</a> </li> </ul><ul><li class="link-1"> <a href="http://www.endocrine.org/endocareers">Journals Career Network</a> </li> </ul> </div> <div class="journal-footer-affiliations">  <a href="http://academic.oup.com/jcem" target=""> <img id="footer-logo-TheJournalofClinicalEndocrinology&Metabolism" class="journal-footer-affiliations-logo" src="//oup.silverchair-cdn.com/data/SiteBuilderAssets/Live/Images/jcem/jcem_f1729907635.svg" alt="The Journal of Clinical Endocrinology & Metabolism" /> </a> </div> <div class="journal-footer-colophon"> <ul> <li>Online ISSN 1945-7197</li> <li>Print ISSN 0021-972X</li> <li>Copyright © 2024 Oxford University Press</li> </ul> </div> </div> </div> </div> <div class="oup-footer"> <div class="center-inner-row"> <div class="widget widget-SelfServeContent widget-instance-OupUmbrellaFooterSelfServe"> <input type="hidden" class="SelfServeContentId" value="GlobalFooter_Links" /> <input type="hidden" class="SelfServeVersionId" value="0" /> <div class="oup-footer-row journal-links"> <div class="global-footer selfservelinks"> <ul> <li><a href="/pages/about-oxford-academic">About Oxford Academic</a></li> <li><a href="/pages/about-oxford-academic/publish-journals-with-us">Publish journals with us</a></li> <li><a href="/pages/about-oxford-academic/our-university-press-partners">University press partners</a></li> <li><a href="/pages/what-we-publish">What we publish</a></li> <li><a href="/pages/new-features">New features</a> </li> </ul> </div> <div class="global-footer selfservelinks"> <ul> <li><a href="/pages/authoring">Authoring</a></li> <li><a href="/pages/open-research/open-access">Open access</a></li> <li><a href="/pages/purchasing">Purchasing</a></li> <li><a href="/pages/institutional-account-management">Institutional account management</a></li> <li><a href="https://academic.oup.com/pages/purchasing/rights-and-permissions">Rights and permissions</a></li> </ul> </div> <div class="global-footer selfservelinks"> <ul> <li><a href="/pages/get-help-with-access">Get help with access</a></li> <li><a href="/pages/about-oxford-academic/accessibility">Accessibility</a></li> <li><a href="/pages/contact-us">Contact us</a></li> <li><a href="/pages/advertising">Advertising</a></li> <li><a href="/pages/media-enquiries">Media enquiries</a></li> </ul> </div> <div class="global-footer selfservelinks global-footer-external"> <ul> <li><a href="https://global.oup.com/">Oxford University Press</a></li> <li><a href="https://www.mynewsdesk.com/uk/oxford-university-press">News</a></li> <li><a href="https://languages.oup.com/">Oxford Languages</a></li> <li><a href="https://www.ox.ac.uk/">University of Oxford</a></li> </ul> </div> <div class="OUP-mission"> <p>Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide</p> <img class="journal-footer-logo" src="//oup.silverchair-cdn.com/UI/app/svg/umbrella/oup-logo.svg" alt="Oxford University Press" width="150" height="42" /> </div> </div> <div class="oup-footer-row"> <div class="oup-footer-row-links"> <ul> <li>Copyright © 2024 Oxford University Press</li> <li><button id="Change-Preferences" type="button" onclick="window.top.document.dispatchEvent(new Event('changeConsent'))">Cookie settings</button></li> <li><a href="https://global.oup.com/cookiepolicy">Cookie policy</a></li> <li><a href="https://global.oup.com/privacy">Privacy policy</a></li> <li><a href="/pages/legal-and-policy/legal-notice">Legal notice</a></li> </ul> </div> </div> <style type="text/css"> /* Issue right column fix for tablet/mobile */ @media (max-width: 1200px) { .pg_issue .widget-instance-OUP_Issue { width: 100%; } } .sf-facet-list .sf-facet label, .sf-facet-list .taxonomy-label-wrap label { font-size: 0.9375rem; } .issue-pagination-wrap .pagination-container { float: right; } </style> </div> </div> </div> <div class="ss-ui-only"> </div> </section> </div> <div class="widget widget-SiteWideModals widget-instance-SiteWideModals"> <div id="revealModal" class="reveal-modal" data-reveal> <div id="revealContent"></div> <a class="close-reveal-modal" href="javascript:;"><i class="icon-general-close"></i><span class="screenreader-text">Close</span></a> </div> <div id="globalModalContainer" class="modal-global-container"> <div id="globalModalContent"> <div class="js-globalModalPlaceholder"></div> </div> <a class="close-modal js-close-modal" href="javascript:;"><i class="icon-general-close"><span class="screenreader-text">Close</span></i></a> </div> <div id="globalModalOverlay" class="modal-overlay js-modal-overlay"></div> <div id="NeedSubscription" class="reveal-modal small" data-reveal> <div class="subscription-needed"> <h5>This Feature Is Available To Subscribers Only</h5> <p><a href="/sign-in">Sign In</a> or <a href="/my-account/register?siteId=5591&returnUrl=%2fjcem%2farticle-abstract%2f95%2f9%2fE80%2f2835175%3fredirectedFrom%3dfulltext">Create an Account</a></p> </div> <a class="close-reveal-modal" href="javascript:;"><i class="icon-general-close"></i><span class="screenreader-text">Close</span></a> </div> <div id="noAccessReveal" class="reveal-modal tiny" data-reveal> <p>This PDF is available to Subscribers Only</p> <a class="hide-for-article-page" id="articleLinkToPurchase" data-reveal><span>View Article Abstract & Purchase Options</span></a> <div class="issue-purchase-modal"> <p>For full access to this pdf, sign in to an existing account, or purchase an annual subscription.</p> </div> <a class="close-reveal-modal" href="javascript:;"><i class="icon-general-close"></i><span class="screenreader-text">Close</span></a> </div> </div> <script type="text/javascript"> MathJax = { tex: { inlineMath: [['|$', '$|'], ['\$', '\$']] } }; </script> <script id="MathJax-script" async src="//cdn.jsdelivr.net/npm/mathjax@3/es5/tex-mml-chtml.js"></script>   <script> var NTPT_PGEXTRA = 'event_type=Login-full-text\u0026supplier_tag=SC_Journals\u0026object_type=Article\u0026taxonomy=taxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00010%7cnodeLabel%3aMedicine+and+Health%7cnodeLevel%3a1%3btaxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00160%7cnodeLabel%3aClinical+Medicine%7cnodeLevel%3a2%3btaxId%3a39%7ctaxLabel%3aAcademicSubjects%7cnodeId%3aMED00250%7cnodeLabel%3aEndocrinology+and+Diabetes%7cnodeLevel%3a3\u0026siteid=jcem\u0026authzrequired=true\u0026turnaway_id=SUB_NONE\u0026doi=10.1210/jc.2010-0109'; </script>  <script type="text/javascript" src="//ouptag.scholarlyiq.com/ntpagetag.js" class="optanon-category-C0002"></script> <noscript> <img src="//ouptag.scholarlyiq.com/ntpagetag.gif?js=0" height="1" width="1" border="0" hspace="0" vspace="0" alt="Scholarly IQ" /> </noscript> <script type="text/javascript" src="//oup.silverchair-cdn.com/Themes/Client/app/jsdist/v-638669719712896271/site.min.js"></script> <script type="text/javascript" src="https://cdn.jsdelivr.net/chartist.js/latest/chartist.min.js"></script> <script type="text/javascript" src="//oup.silverchair-cdn.com/Themes/Client/app/jsdist/v-638669719629345371/article-page.min.js"></script> <div class="ad-banner js-ad-riser ad-banner-riser"> <div class="widget widget-AdBlock widget-instance-RiserAd"> </div> </div> <script src="//oup.silverchair-cdn.com/oup/scm.proxylogging.js"></script> <div class="end-of-page-js"></div> </body> </html>

CINXE.COM

Longitudinal Study of Serum Lipoproteins in Relation to Endogenous Reproductive Hormones during the Menstrual Cycle: Findings from the BioCycle Study | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic