Testimonial Interrogating the Brain's Clock: How Spatial Genomics Enhances SCN Research

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="applicable-device" content="pc,mobile" /> <meta name="description" content="Spatial expert testimonial of using RNAscope ISH in spatial omics to validate discoveries from single-cell data in situ to achieve successful differentiation in the suprachiasmatic nucleus" /> <link rel="canonical" href="https://www.bio-techne.com/resources/testimonials/how-rna-ish-spatial-omics-enhances-scn-research" /> <meta property="og:site_name" content="Bio-Techne" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://www.bio-techne.com/resources/testimonials/how-rna-ish-spatial-omics-enhances-scn-research" /> <meta property="og:image" content="https://resources.bio-techne.com/bio-techne-assets/images/brands/bio-techne-og.png" /> <meta name="brand" content="Advanced Cell Diagnostics" /> <meta name="revision-date" content="1721756976" /> <meta name="published-date" content="1721074006" /> <meta name="research-area" content="Neuroscience Stem Cells" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <script type="application/ld+json">{ "@context": "https://schema.org", "@graph": [ { "@type": "WebPage", "@id": "https://www.bio-techne.com/resources/testimonials/how-rna-ish-spatial-omics-enhances-scn-research", "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bio-techne.com/" }, { "@type": "ListItem", "position": 2, "name": "Resources", "item": "https://www.bio-techne.com/resources" }, { "@type": "ListItem", "position": 3, "name": "Testimonials", "item": "https://www.bio-techne.com/resources/testimonials" } ] } } ] }</script> <meta http-equiv="x-dns-prefetch-control" content="on" /> <meta http-equiv="x-ua-compatible" content="ie=edge" /> <link rel="alternate" hreflang="en" href="https://www.bio-techne.com/resources/testimonials/how-rna-ish-spatial-omics-enhances-scn-research" /> <link rel="alternate" hreflang="zh-hans" href="https://www.bio-techne.com/cn/resources/testimonials/how-rna-ish-spatial-omics-enhances-scn-research" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> <link rel="preconnect" href="https://resources.tocris.com" /> <link rel="preconnect" href="https://i.icomoon.io" /> <link rel="preconnect" href="https://cdn.icomoon.io" /> <link rel="dns-prefetch" href="https://connect.facebook.net" /> <link rel="dns-prefetch" href="https://resources.bio-techne.com" /> <link rel="dns-prefetch" href="https://snap.licdn.com" /> <link rel="dns-prefetch" href="https://www.google-analytics.com" /> <link rel="dns-prefetch" href="https://munchkin.marketo.net" /> <link rel="dns-prefetch" href="https://resources.tocris.com" /> <link rel="dns-prefetch" href="https://i.icomoon.io" /> <link rel="dns-prefetch" href="https://cdn.icomoon.io" /> <title>Testimonial Interrogating the Brain's Clock: How Spatial Genomics Enhances SCN Research | Bio-Techne</title> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_656_2vqy1Km2MYNBaMfnvrWzlHUsrQzYL6gRawV6hgo.css?delta=0&language=en&theme=bio_techne_global&include=eJxNzmFyhDAIBeALJeZIDImsUjFkIWnH21fXtttfb_hmeGDkTavzJ0HHLAQPlk6W7M_jy4Mf3mlPGZ1CZoVOZa0Ei2hGSXdE74dwXcLHc5AdMBi8ca1n30-GoroxQdXODy7YWWu6Lf63mEXLFhoaLoZt9TTbaCjTW6ZR28jCvtIcBA8dHfJgmc9r_UuLCjiVqyw003mUfs5oZU13QMbrnX0nKwTPwWVTu5Z_Lb5ter3zDT02d0M" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_d9gn2GRzRb_AMxXfgjVqY5zLMXvuwkXc1qKvoeAAIxE.css?delta=1&language=en&theme=bio_techne_global&include=eJxNzmFyhDAIBeALJeZIDImsUjFkIWnH21fXtttfb_hmeGDkTavzJ0HHLAQPlk6W7M_jy4Mf3mlPGZ1CZoVOZa0Ei2hGSXdE74dwXcLHc5AdMBi8ca1n30-GoroxQdXODy7YWWu6Lf63mEXLFhoaLoZt9TTbaCjTW6ZR28jCvtIcBA8dHfJgmc9r_UuLCjiVqyw003mUfs5oZU13QMbrnX0nKwTPwWVTu5Z_Lb5ter3zDT02d0M" /> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/12646","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_environment":false},"tagIds":["GTM-N2MWQDR"]},"gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"ajaxPageState":{"libraries":"eJxtkm124yAMRTcEYUkcgRVbE4wYIdK6qx85bpxO2z98XD3ZT0KJOCrmpWKcCycoITFrV4EW81Rd-hE_Nt91K1TnXwSUeWX-LbXAx-YLw7THPkOF7hhhxqrhhH6H_gHtmARkc6kwr4KQl9joHUuYQKHAhuLb6AuKSxqxLlAzThHNw4qSMST1T-pP6jspvtGEHu_2k-5O-ak4LJ-B-HdQvrFMKC_Ni13MXr6Zmm-EsbLSlTIocQ0H81-ZP9RnBSHhAndi6Q4LdKUcG-gSR0eJkDMP8xg-D15Qh1TfrD_WnXpzM_NcMCrMYbbl-_0Cf-D9f7g6qopSH26g0MfTqn1fNt-xYNbDpW8FMi5crEpnbnloTIP2a9A3zlxiN7GluwYCsw3O0sMko0G5vMhl1DZSIXupyTXhaWS1RJC8hGOLCcQJ9sa17zOhkMzvlYoZDS_uH9z1rSuuIUFH92gT1SvLetSxA_8FPIf1H-SbJog","theme":"bio_techne_global","theme_token":null},"ajaxTrustedUrl":[],"dataLayer":{"defaultLang":"en","languages":{"en":{"id":"en","name":"English","direction":"ltr","weight":0},"zh-hans":{"id":"zh-hans","name":"Chinese, Simplified","direction":"ltr","weight":1},"ja":{"id":"ja","name":"Japanese","direction":"ltr","weight":2}}},"internationalization":{"origin":{"id":"sg","label":"SG","country_name":"Singapore","alternate_spellings":"SG","country_enabled":true,"country_encased":false,"commerce_enabled":false,"credit_cards_enabled":true,"region":"North America - ROW","currency":"USD","localities":"","phone_pattern":"","country_shipping":"0","shipping_delay":3,"country_contact_message":"","product_block_message":"","default_language_setting":"none","default_contact_email":""},"languagePrefix":"\/"},"bloomreach_pixel":{"br_info":{"acct_id":"6368","domain_key":"biotechne"},"page_info":{"ptype":"content"},"order_info":{"order_id":""},"user_info":{"uid":0},"searchbar":{"enabled":"1","form":".product-search-form","input":"#edit-keywords"},"atc":{"enabled":"1","form":".add-to-cart-block"}},"user":{"uid":0,"permissionsHash":"085655eba91c5b5dd7808236555504ceb824f9fddd71e3c0265b4003df711142"}}</script> <script src="/sites/default/files/js/js_VXwrJf_GoEAY9I4SWeDh30VrU0-JgQhDzf_eoQcyzA4.js?scope=header&delta=0&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> <script src="/modules/contrib/google_tag/js/gtm.js?snbwxk"></script> <script src="/modules/contrib/google_tag/js/gtag.js?snbwxk"></script> <script src="/sites/default/files/js/js_noO6VL3JUON9fTBkbqcAjEkLsfpTqx94dWIfXpNxuMg.js?scope=header&delta=3&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> </head> <body class="node-12646 node-type-testimonial"> <a href="#main-content" class="visually-hidden focusable"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-N2MWQDR" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div id="page-wrapper"> <div id="page"> <header id="header" class="header" role="banner" aria-label="Site header"> <div class="section layout-container clearfix"> <section id="site-header__top"> <div class="container-fluid container-wide"> <div class="row m___navigation-utility-top"> <div class="col-xl-2 col-lg-12 text-xl-left text-lg-center"> <div id="site-header__logo" class="valign d-none d-lg-block mb-md-3"> <div> <div id="block-sitebranding" class="site-branding system_branding_block"> <a href="/" title="Home" rel="home" class="site-branding__logo"> <img width="160" height="28" src="/themes/custom/bio_techne_global/logo.svg" alt="Home" /> </a> </div> </div> </div> </div> <div class="col d-none d-xl-block text-lg-left text-md-center"> <div class="utility-bar-tagline rotating-text position-absolute"> <p class="ml-xl-4 bt-px_groteskbold text-white mb-0"> Global Developer, Manufacturer, and Supplier of High-Quality<br/> Reagents, Analytical Instruments, and Precision Diagnostics. </p> </div> <div class="utility-bar-brands rotating-text position-absolute ml-xl-4 text-white mb-0"> <div class="row"> <div class="col-2"> <div class="bt-px_groteskbold valign utility-bar-includes">INCLUDES</div> </div> <div class="col-lg-10 col-md-auto bt-inter"> <span class="mr-3">R&D Systems<sup>TM</sup></span> <span class="mr-3">Novus Biologicals<sup>TM</sup></span> <span class="mr-3">Tocris Bioscience<sup>TM</sup></span><br/> <span class="mr-3">ProteinSimple<sup>TM</sup></span> <span class="mr-3">ACD<sup>TM</sup></span> <span class="mr-3">ExosomeDx<sup>TM</sup></span> <span class="mr-3">Asuragen<sup style="font-size:11px;">®</sup></span> <span>Lunaphore<sup>TM</sup></span> </div> </div> </div> </div> <div class="col-xl-auto col-lg-12"> <div class="row"> <div class="col text-xl-left text-center"> </div> </div> <div class="row"> <div class="col text-xl-left text-center"> <nav id="site-header-top__left m___navigation-language"> <div> <div id="block-i18ncountryselect" class="i18n_country_select"> <div id="country-select-block-placeholder"> <div id="country-select-block-spinner" class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </div> </div> </div> </nav> </div> </div> </div> </div> </div> </section> <div id="header-bg" class="bg-bt-secondary"> <section id="site-header__middle"> <div class="container-fluid container-wide"> <div class="row search-row"> <div id="hamburger-col" class="col-3 col-sm-3 col-md-2 d-block d-lg-none"> <button class="navbar-toggler collapsed" type="button" data-toggle="collapse" data-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation"> <span class="icon-bar top-bar"></span> <span class="icon-bar middle-bar"></span> <span class="icon-bar bottom-bar"></span> </button> </div> <div class="col-6 col-sm-6 col-md-8 d-block d-lg-none text-center"> <div id="site-header__logo" class="vertical-align mb-3"> <div> <div id="block-sitebranding" class="site-branding system_branding_block"> <a href="/" title="Home" rel="home" class="site-branding__logo"> <img width="160" height="28" src="/themes/custom/bio_techne_global/logo.svg" alt="Home" /> </a> </div> </div> </div> </div> <div id="tools-col" class="col-3 col-md-12 col-lg-auto order-sm-1 order-md-12 order-lg-12"> <div id="site-header__tools" class="vertical-align"> <div class="row"> <div class="col-md-12"> <div class="d-flex justify-content-end justify-content-md-center justify-content-lg-end"> <div class="text-right order-3 cart-not-available user_cart_information_block" id="block-biotechnecartinformation"> <span ></span> </div> <div class="mr-3 d-none d-md-block order-2 block-quickorderblock quick_order_block" id="block-quickorderblock"> </div> <div class="mr-3 order-1 user_account_information_block" id="block-biotechneuserinformation"> <a class="btn btn-primary" rel="nofollow" href="/account/login" role="button"> <span class="icon icon-bt-icon-user"></span> Sign In / Register </a> </div> </div> </div> </div> </div> </div> <div class="col order-sm-12 order-md-1 order-lg-1"> <div id="site-header__search">  <section role="search" class="vertical-align"> <div> <div class="block-product-search-form-block product_search_form_block" id="block-product-search-form-block"> <div class="row"> <div class="col-sm-12 search-bar mb-md-4"> <form class="product-search-form" action="/search" method="get" id="product-search-form" accept-charset="UTF-8" data-date="2024-11-23 12:11:22"> <div class="container-inline input-group" id="edit-container"> <div class="js-form-type-select"> <select class="dropdown-select text-dark-gray js-search-section-dropdown mr-2 pl-4 pr-5" id="edit-search-type" name="search_type" aria-label="Select search type"> <option value="products">Products</option> <option value="resources">Resources</option> </select> </div> <input placeholder="Search keyword, molecule name, target, catalog number, or product type..." autocomplete="off" class="form-control js-search-bar form-autocomplete form-text required ui-autocomplete-input" title="Search keyword, molecule name, target, catalog number, or product type..." data-autocomplete-path="/ajax/product-search/auto-suggest" type="text" id="product-search-keywords" name="keywords" value="" size="60" maxlength="256" required="required" aria-required="true" data-once="autocomplete" spellcheck="false"> <div class="form-actions" id="edit-actions"> <div class="input-group-append"> <input class="form-submit" type="submit" value=""> </div> </div> </div> </form> </div> </div> </div> </div> </section> </div> </div> </div> </div> </section> <section id="site-header__bottom"> <div class="container-fluid container-wide"> <div class="row"> <div class="col-md-12">  <nav id="main-nav"> <div> <div id="block-bio-techne-global-mainmenublock" class="main_menu_block"> <nav role="navigation" aria-labelledby="block-main-menu" id="block-main-menu" class="contextual-region navbar navbar-expand-md navbar-dark"> <div class="collapse navbar-collapse" id="navbarSupportedContent" data-date="2024-11-22 05:11:30"> <ul class="navbar-nav ml-auto"> <li class="nav-item dropdown d-md-none"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-quick-order" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Quick Order <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-quick-order" aria-labelledby="navbarDropdown-quick-order"> <div class="row"> <a href="/commerce/quickorder" class="dropdown-item text-wrap" title="Quick order form" data-drupal-link-system-path="commerce/quickorder">Quick Order Form</a> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-research-products" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Research Products <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-research-products" aria-labelledby="navbarDropdown-research-products"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/276">Antibodies</a> <a href="/reagents/cell-culture-reagents" class="dropdown-item text-wrap" data-drupal-link-system-path="node/156">Cell Culture Reagents</a> <a href="/reagents/compound-libraries" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1096">Compound Libraries</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a href="/reagents/elispot-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/141">ELISpot Kits</a> <a href="/reagents/enzymes" class="dropdown-item text-wrap" data-drupal-link-system-path="node/246">Enzymes</a> <a href="/reagents/fluorescent-dyes-probes" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6191">Fluorescent Dyes and Probes</a> <a href="/reagents/luminex-assays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/181">Luminex Assays</a> <a href="/reagents/proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/236">Proteins</a> <a href="/reagents/proteome-profiler-antibody-arrays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/206">Proteome Profiler Antibody Arrays</a> <a href="/reagents/rnascope-ish-technology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1626">RNAscope ISH Probes & Assays</a> <a href="/reagents/simple-plex-immunoassays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1531">Simple Plex Immunoassays</a> <a href="/reagents/small-molecules-and-peptides" class="dropdown-item text-wrap" data-drupal-link-system-path="node/371">Small Molecules & Inhibitors</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> GMP Products<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/gmp-products/gmp-proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/511">GMP Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" title="Our capillary electrophoresis instruments (icIEF and CE-SDS) provide reproducible quantitative analysis for thorough therapeutic protein characterization." class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single-Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> <a href="/applications/crispr" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9356">CRISPR</a> <a href="/applications/electrophysiology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/426">Electrophysiology</a> <a href="/applications/flow-cytometry" class="dropdown-item text-wrap" data-drupal-link-system-path="node/321">Flow Cytometry</a> <a href="/applications/imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10181">Imaging </a> <a href="/applications/immunoassays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/496">Immunoassays</a> <a href="/resources/instrument-applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3341">Instrument Applications</a> <a href="/applications/mass-cytometry" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10071">Mass Cytometry (CyTOF)</a> <a href="/applications/spatial-biology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13416">Spatial Biology</a> <a href="/applications/vaccine-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/566">Vaccine Development</a> <a href="/applications/western-blotting" class="dropdown-item text-wrap" data-drupal-link-system-path="node/281">Western Blotting</a> <a href="/applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6736">View All Applications</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cancer" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8791">Cancer</a> <a href="/research-areas/cell-biology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10661">Cell Biology</a> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/research-areas/coronavirus" class="dropdown-item text-wrap" data-drupal-link-system-path="node/576">COVID-19</a> <a href="/research-areas/epigenetics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9511">Epigenetics</a> <a href="/research-areas/hypoxia" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8846">Hypoxia</a> <a href="/research-areas/immunology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10601">Immunology</a> <a href="/research-areas/immuno-oncology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/381">Immuno-Oncology</a> <a href="/research-areas/metabolism" class="dropdown-item text-wrap" data-drupal-link-system-path="node/406">Metabolism</a> <a href="/research-areas/neuroscience" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10591">Neuroscience</a> <a href="/research-areas/organoids-3d-culture" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1452">Organoid and 3-D Culture</a> <a href="/research-areas/stem-cells" class="dropdown-item text-wrap" data-drupal-link-system-path="node/161">Stem Cells</a> <a href="/research-areas/targeted-protein-degradation" class="dropdown-item text-wrap" data-drupal-link-system-path="node/376">Targeted Protein Degradation</a> <a href="/research-areas" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6741">View All Research Areas</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-therapeutic-manufacturing" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Therapeutic Manufacturing <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-therapeutic-manufacturing" aria-labelledby="navbarDropdown-therapeutic-manufacturing"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/cell-culture-reagents/serum-free-animal-free" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3576">Animal-Free Cell Culture</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a href="/therapeutic-manufacturing/simple-plex-assays" class="dropdown-item text-wrap" title="Bioprocess impurities and immunotitration" data-drupal-link-system-path="node/1311">Simple Plex Immunoassays</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> GMP Products<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/gmp-products/gmp-proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/511">GMP Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> <a href="/gmp-products/ruo-to-gmp" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3421">Transition to GMP </a> <a href="/gmp-products/loa-request" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13326">DMF/LOA Request</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/applications/immuno-oncology-clinical" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2066">Immuno-Oncology</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-diagnostics" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Diagnostics <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-diagnostics" aria-labelledby="navbarDropdown-diagnostics"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Controls & Reagents<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/clinical-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7606">Clinical Quality Controls</a> <a href="/diagnostics/molecular-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5596">Molecular Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/custom-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1891">All Custom Services</a> <a href="/services/custom-antibody-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/906">Custom Antibody Services</a> <a href="/services/custom-cell-and-gene-therapy-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1281">Custom Cell & Gene Therapy Services</a> <a href="/services/custom-compound-library-service" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2126">Custom Compound Library Services</a> <a href="/services/custom-elisa-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/261">Custom ELISA Services</a> <a href="/services/gene-engineering-services-tcbuster" class="dropdown-item text-wrap" title="Gene Engineering Services: Bio-Techne" data-drupal-link-system-path="node/1136">Custom Gene Engineering Services</a> <a href="/services/custom-luminex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/271">Custom Luminex Services</a> <a href="/services/custom-protein-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1441">Custom Protein Services</a> <a href="/services/custom-simple-plex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6296">Custom Simple Plex Services</a> <a href="/services/custom-targeted-protein-degradation-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/861">Custom Targeted Protein Degradation Services</a> <a href="/services/professional-assay-services-rnascope" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12306">RNAscope Professional Assay Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/certified-service-provider-program" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5446">Certified Service Provider (CSP) Program</a> <a href="/resources/instrument-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5471">Contract Services</a> <a href="/services/instrument-services/simple-western-service-plans" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3181">Simple Western Service Plans</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Licensing<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/biotechnology-licensing-partnering" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1101">Biotechnology Licensing and Partnering</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup Tool</a> <a href="/resources/rnascope-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/rnascope-citations">RNAscope Citations</a> <a href="/resources/simple-plex-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-plex-panel-builder">Simple Plex Panel Builder</a> <a href="/resources/simple-western-kit-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-kit-builder">Simple Western Kit Builder</a> <a href="/resources/simple-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-antibody-database">Simple Western Antibody Database</a> <a href="/resources/single-cell-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/single-cell-western-antibody-database">Single-Cell Western Antibody Database</a> <a href="/resources/spectra-viewer" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6176">Spectra Viewer</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Scientific Resources<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/blogs" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/blogs">Blogs</a> <a href="/resources/literature" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/literature">Literature</a> <a href="/resources/podcasts/biotech-podcast-back-of-the-napkin" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8601">Podcasts</a> <a href="/resources/protocols-troubleshooting" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/protocols-troubleshooting">Protocols & Troubleshooting</a> <a href="/resources/scientific-articles" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/scientific-articles">Scientific Articles</a> <a href="/resources/signal-transduction-pathways" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/signal-transduction-pathways">Signal Transduction Pathways</a> <a href="/resources/testimonials" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/testimonials">Testimonials & Interviews</a> <a href="/resources/webinars" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1596">Webinars</a> <a href="/resources/videos" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/videos">Videos</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Resources<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/instrument-applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3341">Instrument Applications</a> <a href="/resources/instrument-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/instrument-citations">Instrument Citations</a> <a href="/resources/protocols" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/protocols">Instrument Protocols</a> <a href="/resources/instrument-software-download-center" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/instrument-software-download-center">Instrument Software</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-about" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> About <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-about" aria-labelledby="navbarDropdown-about"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> About Us<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/welcome-to-bio-techne" class="dropdown-item text-wrap" data-drupal-link-system-path="node/876">Welcome to Bio-Techne.com!</a> <a href="/about/about-bio-techne" class="dropdown-item text-wrap" data-drupal-link-system-path="node/16">About Bio-Techne</a> <a href="/brands" class="dropdown-item text-wrap" data-drupal-link-system-path="node/46">Bio-Techne Brands</a> <a href="/about/corporate-and-social-responsibility" class="dropdown-item text-wrap" data-drupal-link-system-path="node/61">Corporate & Social Responsibility</a> <a href="https://investors.bio-techne.com/" target="_blank" class="dropdown-item text-wrap">Investor Relations</a> <a href="/about/quality" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6056">Quality</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Latest at Bio-Techne<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/about/careers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/21">Careers</a> <a href="/about/events" class="dropdown-item text-wrap" data-drupal-link-system-path="node/786">Events</a> <a href="/programs" class="dropdown-item text-wrap" data-drupal-link-system-path="node/4621">Programs & Promotions</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Support<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/support/contact-us" class="dropdown-item text-wrap" data-drupal-link-system-path="node/96">Contact & Support</a> <a href="/distributors" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9936">Distributors</a> </div> </div> </div> </div> </div> </li> </ul> </div> </nav> </div> </div> </nav> </div> </div> </div> </section> </div> </div> </header> </div> <div class="highlighted"> <aside class="container section clearfix" role="complementary"> <div> </div> </aside> </div> <div id="main" class="container-fluid container-wide "> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/resources">Resources</a> </li> <li> <a href="/resources/testimonials">Testimonials</a> </li> <li> Interrogating The Brain's Clock: How Spatial Genomics Enhances SCN Research </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <h1><span>Interrogating the Brain's Clock: How Spatial Genomics Enhances SCN Research</span> </h1> <div class="testimonial_published_dt"> Posted July 15, 2024 </div> <div> <div class="container card testimonial mb-5 p-3"> <div class="row"> <aside class="col-lg-3 text-center m___testimonial-aside"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/testimonials/komal-headshot.png" alt="Dr. Ruchi Komal Ph.D. Headshot" loading="lazy" > <p class="text-center mt-2 font-weight-bold testimonial__profile"> Dr. Ruchi Komal Ph.D. <br/> Research Fellow, Samer Hattar Lab Section on Light and Circadian Rhythms (SLCR) National Institute of Mental Health, NIH </p> </aside> <section class="col-lg-9 m___testimonial-section"> <div class="testimonial__quote"> <p class="font-italic">"RNAscope spatial analysis greatly improves our research by offering high-resolution visualization of gene expression within the SCN..."</p> <p>- Dr. Ruchi Komal Ph.D. , Research Fellow, Samer Hattar Lab Section on Light and Circadian Rhythms (SLCR) National Institute of Mental Health, NIH</p> </div> <div> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Understanding the intricate workings of the brain's suprachiasmatic nucleus (SCN), is a challenging endeavor. Yet, with the aid of RNAscope<sup>TM</sup> <em>in situ</em> hybridization (ISH) spatial omics analysis tools, one researcher has made substantial progress in unveiling the complexities of SCN neuronal structures. Here’s a look into their journey and the pivotal role RNAscope has played. </p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/testimonials/brain-clock-ill.png" alt="brain clock illustration" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h3>Resolution matters, context matters: RNAscope resolves biology at sub-cellular level. </h3><p>"<a href="/reagents/rnascope-ish-technology" target="_blank" rel="noreferrer noopener">RNAscope spatial analysis</a> greatly improves our research by offering high-resolution visualization of gene expression within the SCN," research fellow Dr. Ruchi Komal at NIMH, NIH begins, highlighting the transformative impact of the technology. RNAscope ISH’s advanced visualization capability has been instrumental in “validating <a href="/applications/spatial-biology/rnascope-spatial-transcriptomics" target="_blank" rel="noreferrer noopener">discoveries from single-cell data</a>, identifying rare cell populations, and facilitating gene co-expression analysis <em>in situ</em>.” These features are essential for comprehending the spatial heterogeneity and neuronal structures of the SCN. </p></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-button mb-4 paragraph--view-mode--default w-100"> <div class="row"> <div class="col"> <a href="/reagents/rnascope-ish-technology" class="btn btn-primary" type="link" > Get Started with RNAscope </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h3>Characterization of cellular organization patterns. </h3><p>RNAscope ISH spatial omics tools have not only supported, but significantly advanced neuroscience research objectives. "RNAscope products have been instrumental in facilitating substantial progress and revelations concerning the SCN neuronal structure," Dr. Komal notes. By conducting spatial distribution analyses of neurons, they have achieved successful differentiation within the SCN, identifying classical shell and core areas, alongside newly discovered subtypes. "This refined categorization contributes significantly to our comprehension of SCN complexity and organizational patterns," they add, underscoring the depth of insights gained through RNAscope. </p><p>Beyond the technical benefits, the overall satisfaction with RNAscope ISH solutions and Advanced Cell Diagnostics’ support team is remarkable: "I am amazed and very satisfied with your solutions and the support provided," Dr. Komal shares. This endorsement speaks volumes about the reliability and effectiveness of RNAscope ISH technology, as well as the quality of support that accompanies the technology. </p><p>In summary, RNAscope ISH spatial omics analysis tools have proven to be invaluable in advancing the understanding of the SCN's intricate neuronal structure. Through high-resolution visualization, validation of single-cell data, and identification of rare cell populations, RNAscope  ISH has enabled significant discoveries and progress in the field. Dr. Komal’s experience is a testament to the unique value and transformative potential of RNAscope ISH spatial omics technology in the field of neuroscience research. </p></div> </div> </div> </div> </div> </section> </div> </div> </div> </article> </div> </div> </section> </main> </div> </div> </div> <div id="brandsbar-footer" class="bg-bt-primary"> <div class="container-wide container-fluid text-white"> <div class="row py-5"> <div class="footer-logo col-xl-3 col-lg-auto d-flex"> <img class="brand-bar-footer-logo" src="/themes/custom/bio_techne_global/logo.svg" alt="Bio-techne logo"> </div> <div class="col-xl-9 col-lg-auto"> <p class="ml-xl-4 bt-px_groteskbold footer-tagline">Global Developer, Manufacturer, and Supplier of High-Quality Reagents, Analytical Instruments, and Precision Diagnostics.</p> </div> <div class="included-brands col"> <span class="font-weight-bold mr-3 bt-inter_regular">INCLUDES</span> <span class="mr-3 bt-inter_regular">R&D Systems™</span> <span class="mr-3 bt-inter_regular">Novus Biologicals™</span> <span class="mr-3 bt-inter_regular">Tocris Bioscience™</span> <span class="mr-3 bt-inter_regular">ProteinSimple™</span> <span class="mr-3 bt-inter_regular">ACD™</span> <span class="mr-3 bt-inter_regular">ExosomeDx™</span> <span class="mr-3 bt-inter_regular">Asuragen™</span> <span class="mr-3 bt-inter_regular">Lunaphore™</span> </div> </div> </div> </div> <div id="site-footer__top" class=" pt-4"> <div class="container-wide container-fluid pt-3"> <div> <div class="col-md-12"> <footer> <div> <div class="row"> <div class="col-xl-3 col-md-6 col-xs-12 p-0 text-white bt-inter_regular"> <div> <div id="block-footercolumn1" class="block_content:8da4adc8-094f-4085-8706-613703de4da6"> <div><h4>CONTACT INFORMATION</h4> <p>614 McKinley Place NE<br /> Minneapolis, MN 55413<br /> USA</p> <p>TEL <a href="tel:612 379 2956">612 379 2956</a><br /> Toll-free <a href="tel:800 343 7475">800 343 7475</a><br /> FAX 612 656 4400</p> </div> </div> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 bt-inter_regular"> <div> <nav role="navigation" aria-labelledby="block-footercolumn2-menu" id="block-footercolumn2"> <h4 id="block-footercolumn2-menu">Who We Are</h4> <ul> <li> <a href="/about/about-bio-techne" title="About Bio-Techne" data-drupal-link-system-path="node/16">About Bio-Techne</a> </li> <li> <a href="/brands" title="Brands" data-drupal-link-system-path="node/46">Bio-Techne Brands</a> </li> <li> <a href="/about/careers" title="History" data-drupal-link-system-path="node/21">Careers </a> </li> <li> <a href="/about/corporate-and-social-responsibility" title="Corporate Responsibility" data-drupal-link-system-path="node/61">Corporate & Social Responsibility </a> </li> <li> <a href="/terms-and-conditions" data-drupal-link-system-path="node/686">Terms and Conditions</a> </li> </ul> </nav> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 bt-inter_regular"> <div> <nav role="navigation" aria-labelledby="block-footercolumn3-menu" id="block-footercolumn3"> <h4 id="block-footercolumn3-menu">Investor Relations</h4> <ul> <li> <a href="https://investors.bio-techne.com/">Overview</a> </li> <li> <a href="https://investors.bio-techne.com/news-events">News / Events</a> </li> <li> <a href="https://investors.bio-techne.com/company-information">Company Information</a> </li> <li> <a href="https://investors.bio-techne.com/financial-information">Financial Information</a> </li> <li> <a href="https://investors.bio-techne.com/stock-data">Stock Data</a> </li> <li> <a href="https://investors.bio-techne.com/sec-filings">SEC Filings</a> </li> <li> <a href="https://investors.bio-techne.com/corporate-governance">Corporate Governance</a> </li> </ul> </nav> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 text-white bt-inter_regular"> <div> <div id="block-stayconnectedblock" class="block_content:3f9f347f-6b53-40fd-8dfa-25f57854770b"> <div><h4>Stay Connected</h4> <section class="social-icons mb-3"> <a href="https://www.linkedin.com/company/bio-techne" class="text-white mr-2" aria-label="Follow Bio-techne on LinkedIn"><span class="icon-linkedin rounded-pill p-3"></span></a> <a href="https://www.instagram.com/bio_techne/" class="text-white mr-2" aria-label="Follow Bio-techne on Instagram"><span class="icon-instagram rounded-pill p-3"></span></a> <a href="https://twitter.com/biotechne" class="text-white mr-2" aria-label="Follow Bio-techne on X"><span class="icon-x rounded-pill p-3"></span></a> <a href="https://www.youtube.com/channel/UCCE68f793S1eyQM2E1BH0Bw?reload=9" class="text-white mr-2" aria-label="Bio-techne YouTube channel"><span class="icon-youtube rounded-pill p-3"></span></a> <a href="https://www.facebook.com/BioTechne/" class="text-white" aria-label="Follow Bio-techne on Facebook"><span class="icon-facebook rounded-pill p-3"></span></a> </section></div> </div> </div> <div> <a href="/support/contact-us" class="py-2 mt-3 mb-4 text-center font-weight-bold text-decoration-none text-white">Contact Us </a> </div> </div> </div> </div> </footer> </div> <hr> <div class="pb-5 mt-4 d-flex flex-wrap legal-navigation"> <div class="mb-2"> <a href="https://www.bio-techne.com/privacy-and-cookie-policy" class="mr-4 text-white text-center">Privacy and Cookie Policy</a> </div> <div class="mb-2"> <a href="/sitemap" class="mr-4 text-white">Site Map</a> </div> <div class="text-white">© Copyright 2024 Bio-Techne. All Rights Reserved.</div> </div> </div> </div> </div> </div> <div> <div id="block-cookieblock" class="cookie_block"> <div class="cookie-notification-block" data-expires="100"> <div class="container"> <div class="row pt-4 pb-4 pl-5 pr-5"> <div class="col-lg-10 mb-1"> Bio-Techne uses cookies to provide you with a great website experience. By continuing to use this website you acknowledge this and agree to our cookie policy. <a class="cookie-notification-block__link text-white" href="/privacy-and-cookie-policy">Learn more</a>. </div> <div class="col-lg-2 text-lg-right text-center align-middle"> <a href="#" class="btn btn-primary text-nowrap js-cookies"> I Agree </a> </div> </div> </div> </div> </div> </div> </div> <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar"/> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> <script>window.dataLayer = window.dataLayer || []; window.dataLayer.push({"drupalLanguage":"en","drupalCountry":"US","siteName":"Bio-Techne","brand":"R\u0026D","entityLangcode":"und","entityStatus":"1","entityType":"node","entityBundle":"testimonial","entityId":"12646","entityTitle":"Interrogating the Brain\u0027s Clock: How Spatial Genomics Enhances SCN Research","entityTaxonomy":{"brand":{"342":"Advanced Cell Diagnostics"},"application":{"1056":"Dual RNAscope ISH-IHC","111":"In Situ Hybridization"},"research_area":{"216":"Neuroscience","231":"Stem Cells"}},"userUid":0});</script> <script src="/sites/default/files/js/js_25fMqnS_SV9QKFCPxa9BJeVftykwhKcx00psCZOkjfs.js?scope=footer&delta=0&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> <script src="//resources.bio-techne.com/bio-techne-assets/css/bootstrap/js/bootstrap.bundle.min.js"></script> <script src="/sites/default/files/js/js_f9Ht4rMsmvXFlpOu9q6kVMmELiTwxkNbyS8OBAaG0m0.js?scope=footer&delta=2&language=en&theme=bio_techne_global&include=eJxtkeuSwyAIhV9I1kdykFB1aySDpNv06dc2Tad7-QV8MOcIxiLGlBuHWi4cMHEzHw8IdwgPONKoqJub0LDixuojZ7wU0e64YrdCYUHLYe2sAYlkbdb9MwFlW7XBMsSGVDu7YRKe1qlKxOqjiHVTXAJN7Z_-HqDbNgSSSyKpcjBMPtn8s8T0u_7AT7y6aIFbxkY8BSaZZ1ZiHw0OCi8KvRh_lYmBL2P_7l7jr4n9QaMh58KhiZVTIbQize8M3hnEKjT2riKzMlIOS7ly9a-DwrL2zOoWlWklC51RKfs9hIjqSjPW9lDDWm6H1bivbtC5MtnuAktF4ix1Gnp_L1nxtkEVnNzjs0o7ic672h3AGzjO_Q3uSNiw"></script> </body> </html>

CINXE.COM

Testimonial Interrogating the Brain's Clock: How Spatial Genomics Enhances SCN Research | Bio-Techne