Damar 陌莽i 陌mplant Materyal Y眉zeylerinde Antitrombojenik ve Antibakteriyel Aktiviteyi Artirmaya Y枚nelik Heparin 陌mmobilizasyonu | GCRIS Database

<!DOCTYPE html> <html> <head> <title>Damar 陌莽i 陌mplant Materyal Y眉zeylerinde Antitrombojenik ve Antibakteriyel Aktiviteyi Artirmaya Y枚nelik Heparin 陌mmobilizasyonu | GCRIS Database | University of Economics & Technology </title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/> <meta http-equiv="X-UA-Compatible" content="IE=edge"/> <meta name="Generator" content="DSpace CRIS-6.3.0-SNAPSHOT"/> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="resourcesync sitemap" href="https://gcris.etu.edu.tr/rs/resourcesync.xml" type="application/xml"/> <link rel="shortcut icon" href="/favicon.ico" type="image/x-icon"/> <link rel="stylesheet" href="/static/css/jquery-ui/redmond/jquery-ui-1.12.1.css" type="text/css"/> <link href="/css/researcher.css" type="text/css" rel="stylesheet"/> <link href="/css/jdyna.css" type="text/css" rel="stylesheet"/> <link rel="stylesheet" href="/static/css/bootstrap/bootstrap.min.css" type="text/css"/> <link rel="stylesheet" href="/static/css/bootstrap/bootstrap-theme.min.css" type="text/css"/> <link href="/static/css/font-awesome-5/css/all.min.css" rel="stylesheet"> <link href="/static/css/jstree/themes/default/style.min.css" rel="stylesheet"/> <link rel="stylesheet" href="/static/css/bootstrap/dspace-theme.css" type="text/css"/> <link rel="stylesheet" href="/css/orcid.css" type="text/css"/> <link rel="stylesheet" type="text/css" href="/static/css/dataTables.bootstrap.min.css"/> <link rel="stylesheet" type="text/css" href="/static/css/buttons.bootstrap.min.css"/> <link rel="stylesheet" type="text/css" href="/static/css/responsive.bootstrap.min.css"/> <link rel="stylesheet" href="/static/css/bootstrap/dspace-theme.css" type="text/css"/> <link rel="stylesheet" href="/static/css/bootstrap/grandcris-theme.css" type="text/css"/> <link rel="stylesheet" href="/static/css/bootstrap/grandcris-institution-theme.css" type="text/css"/> <link rel="stylesheet" type="text/css" href="/css/bootstrap-datetimepicker.min.css"/> <link rel="stylesheet" type="text/css" href="/static/css/select.dataTables.min.css"/> <link rel="search" type="application/opensearchdescription+xml" href="/open-search/description.xml" title="DSpace"/> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <meta name="DC.contributor" content="Ero臒ul, Osman" /> <meta name="DC.contributor" content="Evren, Ebru" /> <meta name="DC.creator" content="脰zg眉zar, Hatice Ferda" /> <meta name="DCTERMS.dateAccepted" content="2023-08-20T19:42:26Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.available" content="2023-08-20T19:42:26Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.issued" content="2023" scheme="DCTERMS.W3CDTF" /> <meta name="DC.identifier" content="17.11.2023 tarihine kadar kullan谋m谋 yazar taraf谋ndan k谋s谋tlanm谋艧t谋r." scheme="DCTERMS.URI" /> <meta name="DC.identifier" content="https://hdl.handle.net/20.500.11851/10577" scheme="DCTERMS.URI" /> <meta name="DCTERMS.abstract" content="Ge莽ici ya da kal谋c谋, dahili ya da harici olarak, tedavi ve/veya onar谋m gibi ama莽larla v眉cuda dahil edilen malzemeler implant materyalleri olarak adland谋r谋lmaktad谋rlar. G眉n眉m眉zde artan pop眉lasyon ve uzun ya艧am s眉releri g枚z 枚n眉ne al谋nd谋臒谋nda, implant materyallerin kullan谋m s谋kl谋臒谋, miktar谋 ve s眉releri giderek artmaktad谋r. Bu nedenle kullan谋lan implantlar谋n, kullan谋ld谋klar谋 b枚lgeye uyum sa臒lamalar谋, transplantasyon sonras谋 herhangi bir komplikasyon olu艧mas谋n谋枚nleyecek 艧ekilde tasarlanmalar谋 gerekti臒i sonucuna ula艧谋lmaktad谋r. Tez kapsam谋nda polimerik ve metalik altta艧lar olmak 眉zere iki farkl谋 malzemede heparin ad谋 verilen, klinikte g眉ncel olarak antikoag眉lan ila莽 olarak kullan谋lan biyomolek眉l ile y眉zey modifikasyon stratejilerinin geli艧tirilmesi 眉zerine 莽al谋艧谋lm谋艧t谋r. Polipropilen (PP) tez kapsam谋nda model polimerik malzeme olarak se莽ilmi艧 ve iki basamakta plazma polimerizasyon (PlzP) destekli y眉zey modifikasyonu ger莽ekle艧tirilmi艧tir; (i) oksijen ile a艧谋nd谋rma ve (ii) amince zengin fonksiyonel grup olu艧turma. PlzP tekni臒i ile geli艧tirilen y眉zey modifikasyon parametreleri, temas a莽谋s谋枚l莽眉m, serbest y眉zey enerji hesaplamalar谋, y眉zeyde maksimum azot miktar谋n谋 elde etme, y眉zey p眉r眉zl眉k de臒erinin art谋r谋lmas谋 kriterleri kapsam谋nda de臒erlendirilmi艧 ve optimize parametre tespit edilmi艧tir. Heparin immobilizasyon i艧lemi, saf heparin (hep) ve kovalent ba臒 ajanlar谋 ile destekli (hep*) 莽枚zeltiler kullan谋larak 3 farkl谋 konsantrasyon 眉zerinden test edilmi艧tir. Y眉zeye tutunumu sa臒lanan heparin miktar谋 Toluidine Mavi (TB) boya ile tespit edilmi艧 ve maksimum heparin tutunumunun sa臒land谋臒谋 konsantrasyon, optimize parametre olarak belirlenmi艧tir. Kovalent ba臒 ajanlar谋 ile destekli heparin 莽枚zeltisinin iki basamakta modifiye edilen PP y眉zeyler ile kovalent ba臒 olu艧turdu臒u, FTIR-ATR analizinde saptanan amid I ve II pikleri ile kan谋tlanm谋艧t谋r. Heparin immobilizasyonu protein tutunum miktar谋n谋 referans y眉zeylere g枚re olduk莽a azaltm谋艧, hemokompatibilite testleri kapsam谋nda (platelet tutunum, hemoliz, kinetik-kan p谋ht谋la艧ma oran谋) da olduk莽a etkili sonu莽lar vermi艧tir. Ayr谋ca heparin immobilizasyonunun PP y眉zeylerde antiadherent karakteristi臒i gram pozitif ve gram negatif bakteriler ile test edilmi艧 ve heparinin antibakteriyel mekanizmas谋n谋n "temas ile 枚ld眉rme" oldu臒u sonucuna ula艧谋lm谋艧t谋r. Son olarak BJ insan fibroblast h眉creleri ile ger莽ekle艧tirilen testler sonucunda, geli艧tirilen y眉zeylerin biyouyumlu olduklar谋 ispatlanm谋艧t谋r. Titanyum (Ti) tez kapsam谋nda model metalik malzeme olarak se莽ilmi艧 ve tek basamakta alternatif ak谋m elektroforetik depozisyon (AC-EPD) tekni臒i ile heparin modifikasyonu ger莽ekle艧tirilmi艧tir. Saf halde heparin depozisyonu, temas a莽谋s谋枚l莽眉m, serbest y眉zey enerji hesaplamalar谋 ve y眉zey p眉r眉zl眉l眉k de臒erleri kapsam谋nda incelenmi艧 ve optimize parametre tespit edilmi艧tir. Ba艧lang谋莽ta y眉zeye depozite edilen heparin miktar谋 TB boya ile takip edilmi艧 olmakla birlikte, ilerleyen deney basamaklar谋nda s枚z konusu yakla艧谋m谋n, AC-EPD tekni臒i ile kaplanan heparin miktar谋n谋 saptamada yetersiz oldu臒u saptanm谋艧t谋r. Ti y眉zeylerde heparin depozisyonunun etkisi, PP y眉zeylerde oldu臒u gibi, protein tutunum miktar谋, hemokompatibilite testleri, antiadherent karakteristik ve biyouyumluluk testleri kapsam谋nda detayl谋 olarak ara艧t谋r谋lm谋艧t谋r. 脰zetle, tez kapsam谋nda ger莽ekle艧tirilen 莽al谋艧malar ile hem PP hem de Ti y眉zeylerde farkl谋 stratejilerle y眉zey modifikasyonlar谋 ger莽ekle艧tirilerek heparinin mevcut antikoag眉lan karakteristi臒inden yararlanmakla birlikte, antibakteriyel, antiadherent ve biyouyumluluk karakteristikleri de detayl谋 olarak 莽al谋艧谋lm谋艧 ve literat眉re kazand谋r谋lm谋艧t谋r." xml:lang="en_US" /> <meta name="DCTERMS.abstract" content="Implantable materials are tools that are used in the human body for temporary or permanent, internal or external, treatment or repair, and so on. Nowadays, due to the growing population and long lifetime, the rate, quantity, and duration of these materials are also increasing. Therefore, implantable materials should be biocompatible with the environment in their usage area and be designed to prevent any complications after the transplant. Within the scope of this thesis, two different materials were used as polymeric and metallic substrates for surface modification with an anticoagulation drug that is used in clinics, heparin. Polypropylene (PP) was selected as a model polymeric substrate and plasma-assisted surface modification was applied in two steps: (i) oxygen etching and (ii) amine-rich functional group creation. Surface modification parameters that were held with the plasma polymerization (PlzP) technique were analyzed with contact angle measurements, surface free energy calculations, obtaining the maximum nitrogen amount on the surfaces and increasing the surface roughness values, etc., and the parameters were optimized accordingly. Immobilization of heparin applied as pure heparin (hep) and covalent bond agent assisted (hep*) with 3 different concentration values. The amount of immobilized heparin detected with toluidine blue (TB) dye and the parameter that produces the maximum amount of immobilized heparin were selected as optimal. Covalent bond formation between hep* and PP substrates was proven with amide I and II peaks, which were detected with FTIR-ATR analysis. Compared to the bare PP substrates, heparin immobilization provided a lower amount of adhered protein and much more efficient hemocompatibility testing (platelet adhesion, hemolysis, and kinetic blood coagulation rate) results. Also, the antiadhesive characteristics of heparin-immobilized PP surfaces were tested against both gram-positive and gram-negative bacteria strains, and the antibacterial mechanism of heparin was revealed as "contact killing". Lastly, the biocompatibility of produced surfaces was tested with the BJ human fibroblast cell line. On the other hand, titanium (Ti) was selected as the model metallic substrate, and heparin immobilization onto the surfaces was held in one step with the alternative current electrophoretic deposition (AC-EPD) technique. Parameter optimization was achieved with contact angle measurements, free surface energy calculations, and the surface roughness values of purely deposited heparin. In the beginning, the deposited heparin amount was detected with TB dye, but according to further analysis, this procedure is not appropriate to detect the heparin amount that was deposited with the AC-EPD technique. The effect of heparin deposition on Ti substrates was examined detailedly with adhered protein amount, hemocompatibility tests, antiadhesive characteristics, and biocompatibility, respectively. In brief, within the scope of the thesis, different surface modification techniques with heparin on both PP and Ti surfaces were examined. With the help of the anticoagulant characteristic of heparin, which is already known, also its antibacterial, antiadherent, and biocompatibility characteristics were examined in detail and brought to the literature." xml:lang="en_US" /> <meta name="DC.language" content="tr" xml:lang="en_US" scheme="DCTERMS.RFC1766" /> <meta name="DC.publisher" content="TOBB ET脺" xml:lang="en_US" /> <meta name="DC.rights" content="info:eu-repo/semantics/ClosedAccess" xml:lang="en_US" /> <meta name="DC.subject" content="Biyom眉hendislik" xml:lang="en_US" /> <meta name="DC.subject" content="Bioengineering ; Mikrobiyoloji" xml:lang="en_US" /> <meta name="DC.subject" content="Microbiology ; M眉hendislik Bilimleri" xml:lang="en_US" /> <meta name="DC.subject" content="Engineering Sciences" xml:lang="en_US" /> <meta name="DC.title" content="Damar 陌莽i 陌mplant Materyal Y眉zeylerinde Antitrombojenik ve Antibakteriyel Aktiviteyi Artirmaya Y枚nelik Heparin 陌mmobilizasyonu" xml:lang="en_US" /> <meta name="DCTERMS.alternative" content="Heparin Immobilization on the Intravascular Catheter Surfaces for Improving Antithrombogenicity and Antibacterial Activity" xml:lang="en_US" /> <meta name="DC.type" content="Doctoral Thesis" xml:lang="en_US" /> <meta name="DC.identifier" content="1" xml:lang="en_US" /> <meta name="DC.identifier" content="126" xml:lang="en_US" /> <meta name="DC.relation" content="Tez" xml:lang="en_US" /> <meta name="DC.identifier" content="N/A" /> <meta name="DC.identifier" content="802714" xml:lang="en_US" /> <meta name="DC.identifier" content="N/A" /> <meta name="citation_keywords" content="Biyom眉hendislik; Bioengineering ; Mikrobiyoloji; Microbiology ; M眉hendislik Bilimleri; Engineering Sciences; Doctoral Thesis" /> <meta name="citation_title" content="Damar 陌莽i 陌mplant Materyal Y眉zeylerinde Antitrombojenik ve Antibakteriyel Aktiviteyi Artirmaya Y枚nelik Heparin 陌mmobilizasyonu" /> <meta name="citation_publisher" content="TOBB ET脺" /> <meta name="citation_language" content="tr" /> <meta name="citation_author" content="脰zg眉zar, Hatice Ferda" /> <meta name="citation_pdf_url" content="https://gcris.etu.edu.tr/bitstream/20.500.11851/10577/1/802714.pdf" /> <meta name="citation_date" content="2023" /> <meta name="citation_abstract_html_url" content="https://gcris.etu.edu.tr/handle/20.500.11851/10577" /> <style> header.navbar { background-color: #B22029 !important; } footer.navbar { background-color: #B22029 !important; } .main-header { background-image: url(../../../image/tobb-etu_2048x1365.jpg) !important; } .stats-boxes-container > div.col-md-3:nth-child(4n + 1) > .stats-box { background-color: #bfe3f7; 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Mikrobiyoloji<br />Microbiology ; M眉hendislik Bilimleri<br />Engineering Sciences</td></tr> <td class="metadataFieldLabel">Publisher: </td><td class="metadataFieldValue">TOBB ET脺</td></tr> <td class="metadataFieldLabel">Abstract: </td><td class="metadataFieldValue">Ge莽ici ya da kal谋c谋, dahili ya da harici olarak, tedavi ve/veya onar谋m gibi ama莽larla v眉cuda dahil edilen malzemeler implant materyalleri olarak adland谋r谋lmaktad谋rlar. G眉n眉m眉zde artan pop眉lasyon ve uzun ya艧am s眉releri g枚z 枚n眉ne al谋nd谋臒谋nda, implant materyallerin kullan谋m s谋kl谋臒谋, miktar谋 ve s眉releri giderek artmaktad谋r. Bu nedenle kullan谋lan implantlar谋n, kullan谋ld谋klar谋 b枚lgeye uyum sa臒lamalar谋, transplantasyon sonras谋 herhangi bir komplikasyon olu艧mas谋n谋 枚nleyecek 艧ekilde tasarlanmalar谋 gerekti臒i sonucuna ula艧谋lmaktad谋r. Tez kapsam谋nda polimerik ve metalik altta艧lar olmak 眉zere iki farkl谋 malzemede heparin ad谋 verilen, klinikte g眉ncel olarak antikoag眉lan ila莽 olarak kullan谋lan biyomolek眉l ile y眉zey modifikasyon stratejilerinin geli艧tirilmesi 眉zerine 莽al谋艧谋lm谋艧t谋r. Polipropilen (PP) tez kapsam谋nda model polimerik malzeme olarak se莽ilmi艧 ve iki basamakta plazma polimerizasyon (PlzP) destekli y眉zey modifikasyonu ger莽ekle艧tirilmi艧tir; (i) oksijen ile a艧谋nd谋rma ve (ii) amince zengin fonksiyonel grup olu艧turma. PlzP tekni臒i ile geli艧tirilen y眉zey modifikasyon parametreleri, temas a莽谋s谋 枚l莽眉m, serbest y眉zey enerji hesaplamalar谋, y眉zeyde maksimum azot miktar谋n谋 elde etme, y眉zey p眉r眉zl眉k de臒erinin art谋r谋lmas谋 kriterleri kapsam谋nda de臒erlendirilmi艧 ve optimize parametre tespit edilmi艧tir. Heparin immobilizasyon i艧lemi, saf heparin (hep) ve kovalent ba臒 ajanlar谋 ile destekli (hep*) 莽枚zeltiler kullan谋larak 3 farkl谋 konsantrasyon 眉zerinden test edilmi艧tir. Y眉zeye tutunumu sa臒lanan heparin miktar谋 Toluidine Mavi (TB) boya ile tespit edilmi艧 ve maksimum heparin tutunumunun sa臒land谋臒谋 konsantrasyon, optimize parametre olarak belirlenmi艧tir. Kovalent ba臒 ajanlar谋 ile destekli heparin 莽枚zeltisinin iki basamakta modifiye edilen PP y眉zeyler ile kovalent ba臒 olu艧turdu臒u, FTIR-ATR analizinde saptanan amid I ve II pikleri ile kan谋tlanm谋艧t谋r. Heparin immobilizasyonu protein tutunum miktar谋n谋 referans y眉zeylere g枚re olduk莽a azaltm谋艧, hemokompatibilite testleri kapsam谋nda (platelet tutunum, hemoliz, kinetik-kan p谋ht谋la艧ma oran谋) da olduk莽a etkili sonu莽lar vermi艧tir. Ayr谋ca heparin immobilizasyonunun PP y眉zeylerde antiadherent karakteristi臒i gram pozitif ve gram negatif bakteriler ile test edilmi艧 ve heparinin antibakteriyel mekanizmas谋n谋n "temas ile 枚ld眉rme" oldu臒u sonucuna ula艧谋lm谋艧t谋r. Son olarak BJ insan fibroblast h眉creleri ile ger莽ekle艧tirilen testler sonucunda, geli艧tirilen y眉zeylerin biyouyumlu olduklar谋 ispatlanm谋艧t谋r. Titanyum (Ti) tez kapsam谋nda model metalik malzeme olarak se莽ilmi艧 ve tek basamakta alternatif ak谋m elektroforetik depozisyon (AC-EPD) tekni臒i ile heparin modifikasyonu ger莽ekle艧tirilmi艧tir. Saf halde heparin depozisyonu, temas a莽谋s谋 枚l莽眉m, serbest y眉zey enerji hesaplamalar谋 ve y眉zey p眉r眉zl眉l眉k de臒erleri kapsam谋nda incelenmi艧 ve optimize parametre tespit edilmi艧tir. Ba艧lang谋莽ta y眉zeye depozite edilen heparin miktar谋 TB boya ile takip edilmi艧 olmakla birlikte, ilerleyen deney basamaklar谋nda s枚z konusu yakla艧谋m谋n, AC-EPD tekni臒i ile kaplanan heparin miktar谋n谋 saptamada yetersiz oldu臒u saptanm谋艧t谋r. Ti y眉zeylerde heparin depozisyonunun etkisi, PP y眉zeylerde oldu臒u gibi, protein tutunum miktar谋, hemokompatibilite testleri, antiadherent karakteristik ve biyouyumluluk testleri kapsam谋nda detayl谋 olarak ara艧t谋r谋lm谋艧t谋r. 脰zetle, tez kapsam谋nda ger莽ekle艧tirilen 莽al谋艧malar ile hem PP hem de Ti y眉zeylerde farkl谋 stratejilerle y眉zey modifikasyonlar谋 ger莽ekle艧tirilerek heparinin mevcut antikoag眉lan karakteristi臒inden yararlanmakla birlikte, antibakteriyel, antiadherent ve biyouyumluluk karakteristikleri de detayl谋 olarak 莽al谋艧谋lm谋艧 ve literat眉re kazand谋r谋lm谋艧t谋r.<br />Implantable materials are tools that are used in the human body for temporary or permanent, internal or external, treatment or repair, and so on. Nowadays, due to the growing population and long lifetime, the rate, quantity, and duration of these materials are also increasing. Therefore, implantable materials should be biocompatible with the environment in their usage area and be designed to prevent any complications after the transplant. Within the scope of this thesis, two different materials were used as polymeric and metallic substrates for surface modification with an anticoagulation drug that is used in clinics, heparin. Polypropylene (PP) was selected as a model polymeric substrate and plasma-assisted surface modification was applied in two steps: (i) oxygen etching and (ii) amine-rich functional group creation. Surface modification parameters that were held with the plasma polymerization (PlzP) technique were analyzed with contact angle measurements, surface free energy calculations, obtaining the maximum nitrogen amount on the surfaces and increasing the surface roughness values, etc., and the parameters were optimized accordingly. Immobilization of heparin applied as pure heparin (hep) and covalent bond agent assisted (hep*) with 3 different concentration values. The amount of immobilized heparin detected with toluidine blue (TB) dye and the parameter that produces the maximum amount of immobilized heparin were selected as optimal. Covalent bond formation between hep* and PP substrates was proven with amide I and II peaks, which were detected with FTIR-ATR analysis. Compared to the bare PP substrates, heparin immobilization provided a lower amount of adhered protein and much more efficient hemocompatibility testing (platelet adhesion, hemolysis, and kinetic blood coagulation rate) results. Also, the antiadhesive characteristics of heparin-immobilized PP surfaces were tested against both gram-positive and gram-negative bacteria strains, and the antibacterial mechanism of heparin was revealed as "contact killing". Lastly, the biocompatibility of produced surfaces was tested with the BJ human fibroblast cell line. On the other hand, titanium (Ti) was selected as the model metallic substrate, and heparin immobilization onto the surfaces was held in one step with the alternative current electrophoretic deposition (AC-EPD) technique. Parameter optimization was achieved with contact angle measurements, free surface energy calculations, and the surface roughness values of purely deposited heparin. In the beginning, the deposited heparin amount was detected with TB dye, but according to further analysis, this procedure is not appropriate to detect the heparin amount that was deposited with the AC-EPD technique. The effect of heparin deposition on Ti substrates was examined detailedly with adhered protein amount, hemocompatibility tests, antiadhesive characteristics, and biocompatibility, respectively. In brief, within the scope of the thesis, different surface modification techniques with heparin on both PP and Ti surfaces were examined. With the help of the anticoagulant characteristic of heparin, which is already known, also its antibacterial, antiadherent, and biocompatibility characteristics were examined in detail and brought to the literature.</td></tr> <td class="metadataFieldLabel">URI: </td><td class="metadataFieldValue"><a href="17.11.2023 tarihine kadar kullan谋m谋 yazar taraf谋ndan k谋s谋tlanm谋艧t谋r.">17.11.2023 tarihine kadar kullan谋m谋 yazar taraf谋ndan k谋s谋tlanm谋艧t谋r.</a><br /><a href="https://hdl.handle.net/20.500.11851/10577">https://hdl.handle.net/20.500.11851/10577</a></td></tr> <tr><td class="metadataFieldLabel">Appears in Collections:</td><td class="metadataFieldValue"><a href="/handle/20.500.11851/2095">Biyomedikal M眉hendisli臒i Doktora Tezleri / Biomedical Engineering PhD Theses</a><br/></td></tr> </table><br/> <div class="panel panel-default"><div class="panel-heading"><h6 class="panel-title">Files in This Item:</h6></div> <table class="table panel-body"><tr><th id="t1" class="standard">File</th> <th id="t3" class="standard">Size</th><th id="t4" class="standard">Format</th><th> </th></tr> <tr><td headers="t1" class="standard break-all"><a target="_blank" href="/bitstream/20.500.11851/10577/1/802714.pdf">802714.pdf</a></td><td headers="t3" class="standard">3.82 MB</td><td headers="t4" class="standard">Adobe PDF</td><td class="standard" align="center"><a class="btn btn-primary" target="_blank" href="/bitstream/20.500.11851/10577/1/802714.pdf">View/Open</a></td></tr></table> </div> <a class="btn btn-default" href="/handle/20.500.11851/10577?mode=full"> Show full item record </a> <br/> <br/> <div class="row"> <div class="col-md-12 col-sm-12"> <div class="box-container"> <div class="box-container-inner"></div> <iframe style="height: 450px; 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Damar 陌莽i 陌mplant Materyal Y眉zeylerinde Antitrombojenik ve Antibakteriyel Aktiviteyi Artirmaya Y枚nelik Heparin 陌mmobilizasyonu | GCRIS Database | University of Economics & Technology