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KEGG ENZYME: 3.7.1.23
<!doctype html> <html><head> <title>KEGG ENZYME: 3.7.1.23</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1732781938"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1732781938"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1732781938" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; 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} } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="683"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg2.gif"></a></td><td> </td><td><a name="enzyme:3.7.1.23"></a><font class="title2">ENZYME: 3.7.1.23</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_enzyme.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/kegg-bin/search_htext" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">EC 3.7.1.23 Enzyme <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">maleylpyruvate hydrolase;<br> hbzF (gene name)<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td20 defd"><div class="cel">Hydrolases;<br> Acting on carbon-carbon bonds;<br> In ketonic substances<br> <button class="btn" onclick="location.href='/brite/ko01000+3.7.1.23';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Sysname</span></th> <td class="td21 defd"><div class="cel">(2Z)-4,6-dioxohept-2-enedioate acylhydrolase<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reaction(IUBMB)</span></th> <td class="td20 defd"><div class="cel">3-maleylpyruvate + H2O = maleate + pyruvate [RN:<a href="/entry/R11257">R11257</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction(KEGG)</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/R11257">R11257</a><br> <button class="btn" onclick="location.href='/entry/R11257';return false;">Reaction</button></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Substrate</span></th> <td class="td20 defd"><div class="cel">3-maleylpyruvate [CPD:<a href="/entry/C02167">C02167</a>];<br> H2O [CPD:<a href="/entry/C00001">C00001</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td21 defd"><div class="cel"><div class="cel">maleate [CPD:<a href="/entry/C01384">C01384</a>];<br> pyruvate [CPD:<a href="/entry/C00022">C00022</a>]<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td20 defd"><div class="cel">The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC <a href="/entry/3.7.1.5">3.7.1.5</a>, acylpyruvate hydrolase.<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">History</span></th> <td class="td21 defd"><div class="cel">EC 3.7.1.23 created 2016<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec00350+3.7.1.23">ec00350</a> </span></td><td>Tyrosine metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec01100+3.7.1.23">ec01100</a> </span></td><td>Metabolic pathways</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K20758">K20758</a> </span></td><td>maleylpyruvate hydrolase</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">1 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/5124802">5124802</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Hopper DJ, Chapman PJ, Dagley S</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">The enzymic degradation of alkyl-substituted gentisates, maleates and malates.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">Biochem J 122:29-40 (1971)<br>DOI:<a href="https://doi.org/10.1042/bj1220029">10.1042/bj1220029</a></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">2 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/7400101">7400101</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Bayly RC, Chapman PJ, Dagley S, Di Berardino D</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate hydrolase from Pseudomonas alcaligenes.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">J Bacteriol 143:70-7 (1980)<br>DOI:<a href="https://doi.org/10.1128/JB.143.1.70-77.1980">10.1128/JB.143.1.70-77.1980</a></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td20 defd"><div class="cel">3 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/23204427">23204427</a>]</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td21 repd"><div class="cel">Liu K, Liu TT, Zhou NY</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td20 repd"><div class="cel">HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867.</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td21 repd"><div class="cel">Appl Environ Microbiol 79:1044-7 (2013)<br>DOI:<a href="https://doi.org/10.1128/AEM.02931-12">10.1128/AEM.02931-12</a></div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td20 repd"><div class="cel">[ag:<a href="/entry/ag:ABD64512">ABD64512</a>]</div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExplorEnz - The Enzyme Database: </span></td><td><a href="https://www.enzyme-database.org/query.php?ec=3.7.1.23">3.7.1.23</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">IUBMB Enzyme Nomenclature: </span></td><td><a href="https://iubmb.qmul.ac.uk/enzyme/EC3/7/1/23.html">3.7.1.23</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExPASy - ENZYME nomenclature database: </span></td><td><a href="https://enzyme.expasy.org/EC/3.7.1.23">3.7.1.23</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">BRENDA, the Enzyme Database: </span></td><td><a href="https://www.brenda-enzymes.info/enzyme.php?ecno=3.7.1.23">3.7.1.23</a></td></tr></table></td></tr> <tr><th class="th20 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td20 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?enzyme+3.7.1.23';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>