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<!DOCTYPE html> <html lang="de"> <head> <meta charset="utf-8">  <title>Autophagie bei Synukleinopathien - Molekularen Neurologie | Uniklinikum Erlangen</title> <meta http-equiv="x-ua-compatible" content="IE=edge"> <meta name="generator" content="TYPO3 CMS"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1"> <meta name="robots" content="index,follow"> <meta name="twitter:card" content="summary"> <meta name="apple-mobile-web-app-capable" content="no"> <meta name="google" content="notranslate"> <link rel="stylesheet" href="/_assets/d62557c271d06262fbb7ce0981266e2f/Css/auto-complete.1732120249.css" media="all"> <link rel="stylesheet" href="/_assets/db5fd2ca3057ef07b5244af171451057/Css/ods_osm.1714687028.css" media="all"> <link rel="stylesheet" href="/_frontend/website/bundled/css/default.6c6d42ec.1730828947.css" media="all"> <style> #frame-backgroundimage-21403 { background-image: url('/fileadmin/_processed_/2/f/csm_fallback_MN_01_aaf9cfbe80.jpg'); } 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class="list-normal"><li>[Strg] - [+]: Schrift vergr枚脽ern</li><li>[Strg] - [-]: Schrift verkleinern</li><li>[Strg] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul><br><p><b>F眉r Mac:</b><br> Mit diesen Tastenkombinationen k枚nnen Sie die Schriftgr枚脽e anpassen:<br></p><ul class="list-normal"><li>[Cmd] - [+]: Schrift vergr枚脽ern</li><li>[Cmd] - [-]: Schrift verkleinern</li><li>[Cmd] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul></div><et-popover-arrow></et-popover-arrow></dialog></et-popover-content></et-popover-root></li></ul></nav></div></div></div></div><div class="menu-main-container bg-blue-darkest"><div class="main-navigation-button-container frame-container frame-container-default d-md-none"><button class="btn main-navigation-button p-4" type="button" data-bs-toggle="offcanvas" data-bs-target="#main-navigation" aria-controls="main-navigation" aria-label="Men眉枚ffnen" ><span class="burger-icon"></span></button></div><nav id="main-navigation" tabindex="-1" class="navbar navbar-main frame-container 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id="frame-backgroundimage-21403" class="frame-backgroundimage"><div class="copyright">漏 James Steidl und Sebastian Kaulitzki / fotolia.com</div></div></div></div></div><div class="frame-type-intro"><div class="frame-container frame-container-default"><div class="frame-inner"><header class="frame-header"><h1 class="element-header mb-2"><span>Autophagie bei Synukleinopathien</span></h1></header></div></div></div></div><nav class="breadcrumb-section" aria-label="Brotkr眉melnavigation"><div class="container"><p class="sr-only" id="breadcrumb">Sie sind hier:</p><ol class="breadcrumb"><li class="breadcrumb-item"><a class="breadcrumb-link" href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" 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icon-arrow_right active" aria-current="page"><span class="breadcrumb-text">Autophagie bei Synukleinopathien</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-before-content"></div><div class="section section-default"><div id="c67282" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Autophagie bei Synukleinopathien</span></h2><h3 class="element-subheader "><span>Projektleitung/ Mitarbeiter: PD Dr. W. Xiang</span></h3></div><p>Die Autophagie stellt einen intrazellul盲ren Abbauprozess dar, der bei den Synukleinopathien, wie dem Parkinson-Syndrom pathophysiologisch entscheidend ver盲ndert ist. In zellbiologischen Untersuchungen konnte die Arbeitsgruppe zeigen, dass dieser Mechanismus beim Parkinson-Syndrom nicht nur gest枚rt ist, sondern auch zur Verbreitung der Pathologie auf umgebende Neurone entscheidend mit beitr盲gt. Hier sind sogenannte Exosomen verantwortlich, sowohl sch盲digende, als auch sch眉tzende Informationen zwischen den Zellen auszutauschen. Beim Parkinson-Syndrom kommt es durch pathologische Proteinablagerungen zu oxidativem Stress, welcher eine gest枚rte zellul盲re Atmung (Funktion der Mitochondrien) hervorruft und den Informationsaustausch zwischen den Zellen ma脽geblich beeinflusst.</p><p><strong>Kooperationspartner: </strong><br> Prof. Dr. C.D. 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