CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "journals.aai.org",cType: 'managed',cRay: '8e71ee3caca56baa',cH: '0horVqwpErzx_Aqvj4JXZ1M9xAUuABF1RCzxORCtX4E-1732372996-1.2.1.1-RFIJnLglN_VSkKHZNRRMgbFeZKt0F9jfkQUwQxX2jc37vKZ0RQcgp_IWGJiRsSzo',cUPMDTk: "\/jimmunol\/article\/194\/12\/6177\/99432\/Generation-of-TCR-Engineered-T-Cells-and-Their-Use?__cf_chl_tk=6VG1CAQHv5SbKDjljpUhNYzWqirqysjX6_dykjbaoRQ-1732372996-1.0.1.1-JDiqFXbLWvvJMOCvhvoflhgYpbsyJ7390wExQ9FfaVA",cFPWv: 'g',cITimeS: '1732372996',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/jimmunol\/article\/194\/12\/6177\/99432\/Generation-of-TCR-Engineered-T-Cells-and-Their-Use?__cf_chl_f_tk=6VG1CAQHv5SbKDjljpUhNYzWqirqysjX6_dykjbaoRQ-1732372996-1.0.1.1-JDiqFXbLWvvJMOCvhvoflhgYpbsyJ7390wExQ9FfaVA",md: "sKcf61yRkIlpo3c9N0jeX49g.LQYJsWRw.SyzwmL6Vk-1732372996-1.2.1.1-4Xh12BKI24SyYtayfdHRgC7TpmYpXIdKsXiY3d.DJMiBPgH5YnT4zd6nhPEq.22aVeBC3V1SFBQ1x6MmL3nrfNWkeW4xhjmmdqKwQYKG8YowNrhSHFsiVkOJkiIpFpa0O_KCWasnvWQFBtoH6eal8RD1I1uuH2E3i.dHiOD.5M2F09qVJT0hrx7npZp7hadrHQO5w9.wuvIrsiyQQ6kI5FmkpfLJEAEeZE2PtBbJm5hCJA_GAQ4R4_Nkq7LjPEi5zE5fReY8eiueDjS76POl27XyPMNG0H16q7zze6oF93PKngDHE83GCtoolsoPHx6jT58fX0TjCRLFMqZ.GxQWhgy5H0uy1KeJcs1Onvu9NcrkpIaqIuPGqLXv1l.9wIKTGJ9_SLa2QhJ97aDiG2mhEm6T8e3scp21KlcCouWa8WOqWRHkN2pGliBYClwwbDLp460D3x1dR0IYuaTWpbqpaZ8PKv28hy3ikXKbZ.NLAyI_UIvlnqto9r4N8_p.WgeszVoD798zobfSz6bwY6zNRMNNc_lb3KIcqabBYFvRecGSvG7y.3Bdb6fTvvLwSuToJYL7iIJTcaoMXzLeUh9RnZ_6Z7orjhbsUohV.KjAbRugWN_eUJnxmVnwD6wBGcK7mGqs3Y5T96c75ZYpsAkTpKyOuvZ9MgEIK7gJlxwAxoNz3N5aj4PjTGdHu19i5odHf5LvahP0ASdy0LkPh77kNhhu86zwBuGaE3nhCcWxBgWotBNsnDDAVKYqKLKEBofwePqdEFAz_yGRGTk9TMrSfw73wZbboDw9mQuEYk19iDUMuTQ5AstaTMnQpR.EWaFOBk7CjoeYGnIwXfb2HENi_Tdqg9e4B6L793cdNIIUm.bSaGigycpVFeXUvDGplBI1_LsMMVv134XWmR7d6m1s508.G_2UjGWJyKqZCKfqXnSoKP3ThukSl04uRvVKtqT_dAaSiXzSjXmonph8bYIyd97HDitzmsB6Cpxg0BjzJ1qMNhVInRaTdaN5llsROvNVCbCzxtFNNN0t2dQCNyhQ4UplABc0qS6SHv22NjRzvcEe7VrbhZLDgyKv8189AUFat.JwDUNLyQd6wKsZXJyoGgcPgB0O6m_uLWaJMj3dAC1Cyv60E32O3GR2UoL0IOe9TaXD02_k77ooiLJBrs1_ENGQ10.hxmRnn.RLqealRLgOcK6NtCME3Y9nLH3h9pZJxEup19h16iC0oPP96TqaJNz2Mkni4J_RfYmVvkVvBMKtRlC1MemMt2k3r6Kfwb1dpE.XZUPEfzaRvVkmxFD9U8yHNYCIWmMTuH9sixkJJDVIq15I7I6eloUK5.7m954xDb46Z.XMUqPkYssqXBkcJTPFIds2Hwl85YLxurWVY15gYN.IkK0oVWjimh.vFLGwPset2n4HaoItKavQR2VFsQHmllmuBAkoBr2SGA6MTgNuoRvwI1FJPSdLQMuK4eE9GTs9p9C.ooq2ATE1BdoLWmDVYx9AaL3D0.m7kDLQcXzfLN_OE4gwcb2JAQ3SiULdPj78VExDEERBVCwDggXRYb8r.y1QPthoGHhcOvcu29GzC2V0GKAJUE4dqWm6AbOQB7EsW.8H0ZM2Ul6IuaPfCn9wEcGgOPPLHVg.q8wZy6UaShr6n334WetoCBmPUaWyMZfFbg3.zY9QVojkmafDKbmpmCgVSxS.eOGLBJpCNpfazK80HoXbGZOU23sEnaGQC6GS6LL7ugMLIn2PYlTXZkbIK5d6DT6VxLvSuxFV7_nlXXJDmi0dJy0EhCfIrJSExNGjy2uu7pWizOrcht4yQ5RaEiKabFZTHs5OnwcCssQ_wKV22vM6wAT3vVG0bVJm7FPpX6telXLtNBXzMYJFJ.HVLyb56A9.Ou.fpZyEFClIn8iK_6r.Q8KePbnc_j7QeQJysEz_MbQktCAmTT9D2LSz0PNt6CugzvAcW4Eqxi6yk_FlBB90FLCEAX_Aw3LabbWTu2Tox1CmH00G0lkM_h7TM6wKEGOqVlqYEKIVKuc_NFEXAh4KYzoZh.ym5s_giraWalqRq61EiZLQpHgKbdlaH9SunZ7zYfu0jUjhLPXiyGsAK6XQljE6w_esRs1oDAGl3uFruJ.8l2o7LYHjVE8kub9nRSbyyuwgRexQSXz7B2xICXPSM_n.wbD4XOBsbmiu9hsfysJlsAQCywkjTo1KXKvOx7R3TJ_h7yYpWI9RH8iZK77SJxdHp11a8oBBU2ClP_KxpGKydjhhxq6jkUw.5lM.fcKdJ999EZlEtwW8ZNC5WjGVluKgGxvOk_gH9zLbd2vMJCMwSqRDmcEQdxz0QkH1rbsxQtV6jCQIHNhSMMiVAVN7pj_6NhNZ4Jq76wsYRgAuBbLbBqG4FHndrlDyOPZCyLm.77BXCFgo4OL2INVRioj25WdNfNLQ3SHibDSDoxngdgGK_9If.UMKmYzkhbB_uipsZoAFMCOgowih02zr8S0MdrFKj1mqVWsvXiHBBrVl9c37_Hej1pL_8PRnnd98pZeh6oxwQtGyMxQXo4l2GaN4ZUfj13ZsIpU7PMqZFowXuhapVA5F2.Ichh1PZxHeZn.aG_aLhUw0EVHtL4YZe3EUTSKS49Oc_RDZLE71jJG1WbYz5GN5xZ6a.FLuykOIaoAFxupnZXXKCArO6wNGIep5QxgQ1YfpKKRoMPWcH_UVh5ALPhWypVBvnNP9lfw0vigXIPsClZT3cW.6acs4lPwUCNW9EHmtkT_RPBmhDgYV66Vz4RaW1skJtbenQJA6.EpWqcRGApRL7FmXx5QuvA.lTZuKyVnlZqyaqmd8K0paE0zYHGKzlQyc1A.ZozN4SHHhLRS.u0aP271vwL6ENYfCLzzwoIYR2mla9c_v_dn2l6QJwjfpw1jEC_1pOpy8wI_liBNv7exnRa8kKTQbqPvlGZ.PESCgLsSUtGOgkMWojIhhT57JuNOABcv_UFs3NXW51JHO.kfewzqroXht1J2ba5_JmijLSjM8nFGRvlg8B6ShBPnly2nG.UpG9QfceU_GSSQ0cV8RMlFeVGfGFrZJZVQ1YbHYrq6ELJvQf0izddJUdVaVUWzKptjF3ua56h2Tk0FU_SP7WkMVv4E2C9bK_NJc30BVcEcz",mdrd: "YBFUmZhvPLB9eGKZViA.IxwWmtyqhS9OZv6iAY6bxbw-1732372996-1.2.1.1-xMCjAoD1VwFJQZ8iUr5AEI_L3.oCDFlfcYIrbiRgnVOfrM0eOdb202.aS1LzPlOwJ2ES2sMfiHVgG9TiWNdLeDIPmiuJoepqrZ0dr15CvTjrfw5MdE2BOtzDClqfzej67A3SGbxZfpnuNTJB_Wxs_ACvfm4BTc.UJagESY1YNFB2FMpDN4NXlB9gRNshpdycLvVOULUg1kvenYqyM3vcebZhpYxCWTi35VOKk8Rp8EMKpiyu8k3Uo9uL5Enedlfua3Grtqy6LebXFwXbFlP1700SKEymJMUvaDupbTJTjgPz1tPIr7vgeyquKkuI8kC03Hc1pABKBJIyfM4bvPsWBS2mQQZy1VPtUGlhSjJuN3DJ7BRlS9XuWfCrQ66WpQEWz.cmTRiJcx8cAXTLpTC2EjFypIQlBiAX5w4X6N8HofqvB3s.v_.aS623iN_zhGoEGV408IblXC9zn90Gx8FirFcdxslGw8Qvb6FfN_QqLisqXuHlj6pSoKj1Iz30DiHgUyoJisbjKAqy7ttBhoP4dV4hNTY0xkPwi1N7JYlxzkSzHo2e5PSD9RQJX0jXEUK5HS6UO4Qnl3jW7XvO1Tyy8zEwGRNw_IfRDkMRjGt4Jcxx5Uj7qsgnec3EV72wC9MhChWMx6orD2sM1HSIquC.9IJ2Fl7luCpNcRejgQD7PQlakPfVt44TrKG2mR1K5f0iHUJHNXO_Q8dkAB7xkk.GL2bk0SimTQVglS44XqkVOo.Xz5mXpaaOIlg5pW1nuXef0HhQDnHCuVQEuvOqKyZODTuNbkrL8.D9CMJ25mDLJfv3Gd5lKPInW52HYQIgVZ0csyZ8OmFpA6QyOwEIIElazowet3JXPQA_1D2u5Yf8ZMK80OaM4RR3V8IuaWONY3XgvRWMe8fgCd2BzQS9KO6rReHuJ3qmN0OFh36l.NxGbXn.VqN40iRb76pbXGus6.FUHtMRYYGWMd_nGv51rEqQnrBSdZuTF8G5SOO0G2VLKZ8evXASSgqi_OrDlruAIbFTYXg3KxH.otpMMIBK.cq5.S5j3Gmyo_OH8XrOFrWyuQfdm2nQMRSNKP3KBG0XhIb4pzY6PZvQFEp24C64_cbMorYygLJ0uMlvy3dKWLWXN2X4ecqNWYzhlWn__AqZbpwQct93qjxAk4oQ29kD.mPQf6dbbSSlz0TSrQ3yQ0FYnV2PBs_91E_kve4Z5dU8e7AfWLYm5udSmRzij9pb5QI_6Jag7gxEcT02uXQii9NUBMjMAznH5AwAhbacf6s6zIIknXiScA_G4pwZddoDDTdHoyr.TfwXff7atDZ_Jk5JgjQXr.FpMGlIgIWSsoagD5.67oh90o3k1sqhmLxTHU2NN3BxINQKgk9L20joaMbgl.30UcIRsPQ2Ht7kGWFbARhe09pmMIl8v.7H0t6COHWLMiTZLPYZLKyLe0jGaiZFYSM2eh9go1ga5bKdv17Ba9LBGEdz0m6jKSZa29QTeNB2M56HDLPEPITw3D2M2M8p3cH5ckcbJBv1XDgsJ6mC5pG6EkfHLzoNYkeoPAjjbaGVhPzfuTZUkEXyOpTHeJ5Xa_4NOUK.zDD.FU1P3UGSTT3wxBuqpTNSgQghpDIJaNHd5V.AFmJC7ij5S2EkW7HO2w1Tg.8rB7wc2vo5GSFYWWM6I2BIi48Julii1xza4ko.OEFWtr3fhv7oQD1WUshYgPZ_EYG.cLH6RorihjnOgwJDJTI1ur5xzghmmPfgFHqp7hZYgVqEr4E6Uu7zZJkburUGURd39nSBWVFqVcEs7Jby4BF_If8_sCCVph5dtruxjaJvtb0V6A3fQAN3hnA7d0kxHdhDX4KC7JyCzZ6xY9wAqy9c9RUk7J3Zv8ff7tCKLMPgilF_gfcaBLvtYmqW1vxl0odMnFFQLOZRYM6wD5PgRqoy14DYVIeXO2aoTWUTmfwJItpPdlu7n1Q4Y_1kuqU"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=8e71ee3caca56baa';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/jimmunol\/article\/194\/12\/6177\/99432\/Generation-of-TCR-Engineered-T-Cells-and-Their-Use?__cf_chl_rt_tk=6VG1CAQHv5SbKDjljpUhNYzWqirqysjX6_dykjbaoRQ-1732372996-1.0.1.1-JDiqFXbLWvvJMOCvhvoflhgYpbsyJ7390wExQ9FfaVA" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>