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</div> <div id="contentSub"><div id="mw-content-subtitle">← <a href="/wiki/UH-232" title="UH-232">UH-232</a></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-undo-success"><div class="mw-parser-output"> <style data-mw-deduplicate="TemplateStyles:r1238441935">.mw-parser-output .fmbox{clear:both;margin:0.2em 0;width:100%;border:1px solid #a2a9b1;background-color:var(--background-color-interactive-subtle,#f8f9fa);box-sizing:border-box;color:var(--color-base,#202122)}.mw-parser-output .fmbox-warning{border:1px solid #bb7070;background-color:#ffdbdb}.mw-parser-output .fmbox-editnotice{background-color:transparent}.mw-parser-output .fmbox .mbox-text{border:none;padding:0.25em 0.9em;width:100%}.mw-parser-output .fmbox .mbox-image{border:none;padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .fmbox .mbox-imageright{border:none;padding:2px 0.9em 2px 0;text-align:center}.mw-parser-output .fmbox .mbox-invalid-type{text-align:center}@media screen{html.skin-theme-clientpref-night .mw-parser-output .fmbox-warning{background-color:#300}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .fmbox-warning{background-color:#300}}</style><table id="mw-undo-success" class="plainlinks fmbox fmbox-editnotice" role="presentation"><tbody><tr><td class="mbox-text"><div> <p><b>You are about to <a href="/wiki/Help:Reverting" title="Help:Reverting">undo</a> an edit.</b> Please check the comparison below to verify that this is what you want to do, then publish the changes below to finish undoing the edit. </p><p><i>If you are undoing an edit that is not <a href="/wiki/Wikipedia:Vandalism" title="Wikipedia:Vandalism">vandalism</a>, explain the reason in the edit summary. Do not use the default message only.</i> </p> </div></td></tr></tbody></table> </div></div><p>You do not have permission to edit this page, for the following reasons: </p> <ul class="permissions-errors"><li class="mw-permissionerror-blockedtext"> <div id="mw-blocked-text" style="border: 1px solid #AAA; background-color: var(--background-color-warning-subtle, ivory); color: inherit; padding: 1.5em; width: 100%; box-sizing: border-box;"> <div style="text-align: center;"><span style="font-size: 26px;"><span typeof="mw:File"><a href="/wiki/File:Stop_hand_nuvola.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/en/thumb/f/f1/Stop_hand_nuvola.svg/50px-Stop_hand_nuvola.svg.png" decoding="async" width="50" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/f1/Stop_hand_nuvola.svg/75px-Stop_hand_nuvola.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/f1/Stop_hand_nuvola.svg/100px-Stop_hand_nuvola.svg.png 2x" data-file-width="240" data-file-height="240" /></a></span><b> This IP address has been <a href="/wiki/Wikipedia:Blocking_policy" title="Wikipedia:Blocking policy">blocked</a> from <i>editing</i> Wikipedia.</b></span><br /><span style="font-size: 18px;">This does not affect your ability to <i>read</i> Wikipedia pages.</span></div><div class="paragraphbreak" style="margin-top:0.5em"></div><b>Most people who see this message have done nothing wrong.</b> Some kinds of blocks restrict editing from specific service providers or telecom companies in response to recent abuse or vandalism, and can sometimes affect other users who are unrelated to that abuse. Review the information below for assistance if you do not believe that you have done anything wrong.<div class="paragraphbreak" style="margin-top:0.5em"></div> <p>The IP address or range 8.222.128.0/17 has been <a href="/wiki/Wikipedia:Blocking_policy" title="Wikipedia:Blocking policy">blocked</a> by <a href="/wiki/User:L235" title="User:L235">‪L235‬</a> for the following reason(s): </p> <div style="padding:10px; background:var(--background-color-base, white); color:inherit; border:1px #666 solid;"> <div class="user-block colocation-webhost" style="margin-bottom: 0.5em; background-color: #ffefd5; border: 1px solid #AAA; padding: 0.7em;"> <figure class="mw-halign-left" typeof="mw:File"><span><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/Server-multiple.svg/40px-Server-multiple.svg.png" decoding="async" width="40" height="57" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/Server-multiple.svg/60px-Server-multiple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/53/Server-multiple.svg/80px-Server-multiple.svg.png 2x" data-file-width="744" data-file-height="1052" /></span><figcaption></figcaption></figure><b>The <a href="/wiki/IP_address" title="IP address">IP address</a> that you are currently using has been blocked because it is believed to be a <a href="/wiki/Web_hosting_service" title="Web hosting service">web host provider</a> or <a href="/wiki/Colocation_centre" title="Colocation centre">colocation provider</a>.</b> To prevent abuse, <a href="/wiki/Wikipedia:Open_proxies" title="Wikipedia:Open proxies">web hosts and colocation providers may be blocked</a> from editing Wikipedia. <div style="border-top: 1px solid #AAA; clear: both">You will not be able to edit Wikipedia using a web host or colocation provider because it hides your IP address, much like a <a href="/wiki/Wikipedia:Open_proxies" title="Wikipedia:Open proxies">proxy</a> or <a href="/wiki/Virtual_private_network" title="Virtual private network">VPN</a>. <p><b>We recommend that you attempt to use another connection to edit.</b> For example, if you use a proxy or VPN to connect to the internet, turn it off when editing Wikipedia. If you edit using a mobile connection, try using a Wi-Fi connection, and vice versa. If you are using a corporate internet connection, switch to a different Wi-Fi network. If you have a Wikipedia account, please log in. </p><p>If you do not have any other way to edit Wikipedia, you will need to <a href="/wiki/Wikipedia:IP_block_exemption#Requesting_and_granting_exemption" title="Wikipedia:IP block exemption">request an IP block exemption</a>. </p> <style data-mw-deduplicate="TemplateStyles:r1214851843">.mw-parser-output .hidden-begin{box-sizing:border-box;width:100%;padding:5px;border:none;font-size:95%}.mw-parser-output .hidden-title{font-weight:bold;line-height:1.6;text-align:left}.mw-parser-output .hidden-content{text-align:left}@media all and (max-width:500px){.mw-parser-output .hidden-begin{width:auto!important;clear:none!important;float:none!important}}</style><div class="hidden-begin mw-collapsible mw-collapsed" style=""><div class="hidden-title skin-nightmode-reset-color" style="text-align:center;">How to appeal if you are confident that your connection does not use a colocation provider's IP address:</div><div class="hidden-content mw-collapsible-content" style=""> If you are confident that you are not using a web host, you may <a href="/wiki/Wikipedia:Appealing_a_block" title="Wikipedia:Appealing a block">appeal this block</a> by adding the following text on your <a href="/wiki/Help:Talk_pages" title="Help:Talk pages">talk page</a>: <code>{{<a href="/wiki/Template:Unblock" title="Template:Unblock">unblock</a>|reason=Caught by a colocation web host block but this host or IP is not a web host. My IP address is _______. <i>Place any further information here.</i> ~~~~}}</code>. <b>You must fill in the blank with your IP address for this block to be investigated.</b> Your IP address can be determined <span class="plainlinks"><b><a class="external text" href="https://en.wikipedia.org/wiki/Wikipedia:Get_my_IP_address?withJS=MediaWiki:Get-my-ip.js">here</a></b></span>. Alternatively, if you wish to keep your IP address private you can use the <a href="/wiki/Wikipedia:Unblock_Ticket_Request_System" title="Wikipedia:Unblock Ticket Request System">unblock ticket request system</a>. There are several reasons you might be editing using the IP address of a web host or colocation provider (such as if you are using VPN software or a business network); please use this method of appeal only if you think your IP address is in fact not a web host or colocation provider.</div></div> <p><span class="sysop-show" style="font-size: 85%;"><span style="border:#707070 solid 1px;background-color:#ffe0e0;padding:2px"><b>Administrators:</b></span> The <a href="/wiki/Wikipedia:IP_block_exemption" title="Wikipedia:IP block exemption">IP block exemption</a> user right should only be applied to allow users to edit using web host in exceptional circumstances, and requests should usually be directed to the functionaries team via email. If you intend to give the IPBE user right, a <a href="/wiki/Wikipedia:CheckUser" title="Wikipedia:CheckUser">CheckUser</a> needs to take a look at the account. This can be requested most easily at <a href="/wiki/Wikipedia:SPI#Quick_CheckUser_requests" class="mw-redirect" title="Wikipedia:SPI">SPI Quick Checkuser Requests</a>. <b>Unblocking</b> an IP or IP range with this template <b>is highly discouraged</b> without at least contacting the blocking administrator.</span> </p> </div></div> </div> <p>This block will expire on 18:23, 24 August 2026. Your current IP address is 8.222.208.146. </p> <div class="paragraphbreak" style="margin-top:0.5em"></div><div style="font-size: 16px;"> <p>Even when blocked, you will <i>usually</i> still be able to edit your <a href="/wiki/Special:MyTalk" title="Special:MyTalk">user talk page</a>, as well as <a href="/wiki/Wikipedia:Emailing_users" title="Wikipedia:Emailing users">email</a> administrators and other editors. </p> </div> <div class="paragraphbreak" style="margin-top:0.5em"></div><div style="font-size: 16px;"> <p>For information on how to proceed, please read the <b><a href="/wiki/Wikipedia:Appealing_a_block#Common_questions" title="Wikipedia:Appealing a block">FAQ for blocked users</a></b> and the <a href="/wiki/Wikipedia:Appealing_a_block" title="Wikipedia:Appealing a block">guideline on block appeals</a>. The <a href="/wiki/Wikipedia:Guide_to_appealing_blocks" title="Wikipedia:Guide to appealing blocks">guide to appealing blocks</a> may also be helpful. </p> </div> <p>Other useful links: <a href="/wiki/Wikipedia:Blocking_policy" title="Wikipedia:Blocking policy">Blocking policy</a> · <a href="/wiki/Help:I_have_been_blocked" title="Help:I have been blocked">Help:I have been blocked</a> </p> </div></li><li class="mw-permissionerror-globalblocking-blockedtext-range"> <div id="mw-blocked-text" style="border: 1px solid #AAA; background-color: var(--background-color-warning-subtle, ivory); color: inherit; padding: 1.5em; width: 100%; box-sizing: border-box;"> <div style="text-align: center;"><span style="font-size: 26px;"><span typeof="mw:File"><a href="/wiki/File:Stop_hand_nuvola.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/en/thumb/f/f1/Stop_hand_nuvola.svg/50px-Stop_hand_nuvola.svg.png" decoding="async" width="50" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/f1/Stop_hand_nuvola.svg/75px-Stop_hand_nuvola.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/f1/Stop_hand_nuvola.svg/100px-Stop_hand_nuvola.svg.png 2x" data-file-width="240" data-file-height="240" /></a></span><b> This IP address range has been <a href="https://meta.wikimedia.org/wiki/Global_blocks" class="extiw" title="m:Global blocks">globally blocked</a>.</b></span><br /><span style="font-size: 18px;">This does not affect your ability to <i>read</i> Wikipedia pages.</span></div><div class="paragraphbreak" style="margin-top:0.5em"></div><b>Most people who see this message have done nothing wrong.</b> Some kinds of blocks restrict editing from specific service providers or telecom companies in response to recent abuse or vandalism, and can sometimes affect other users who are unrelated to that abuse. Review the information below for assistance if you do not believe that you have done anything wrong.<div class="paragraphbreak" style="margin-top:0.5em"></div><div class="paragraphbreak" style="margin-top:0.5em"></div> <p>This block affects editing on all Wikimedia wikis. </p><p>The IP address or range 8.222.128.0/17 has been globally <a href="/wiki/Wikipedia:Blocking_policy" title="Wikipedia:Blocking policy">blocked</a> by <a href="/wiki/User:Jon_Kolbert" title="User:Jon Kolbert">‪Jon Kolbert‬</a> for the following reason(s): </p> <div style="padding:10px; background:var(--background-color-base, white); color:inherit; border:1px #666 solid;"> <p><a href="https://meta.wikimedia.org/wiki/Special:MyLanguage/NOP" class="extiw" title="m:Special:MyLanguage/NOP">Open proxy/Webhost</a>: See the <a href="https://meta.wikimedia.org/wiki/WM:OP/H" class="extiw" title="m:WM:OP/H">help page</a> if you are affected </p> </div> <p>This block will expire on 15:12, 27 August 2028. 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a microdialysis study | journal = European Journal of Pharmacology | volume = 242 | issue = 2 | pages = 151–63 | date = September 1993 | pmid = 8253112 | doi = 10.1016/0014-2999(93)90075-S }}</ref><ref>{{cite journal | vauthors = Aretha CW, Sinha A, Galloway MP | title = Dopamine D3-preferring ligands act at synthesis modulating autoreceptors | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 274 | issue = 2 | pages = 609–13 | date = August 1995 | pmid = 7636720 }}</ref> It causes dopamine release in the brain and has a [[stimulant]] effect,<ref>{{cite journal | vauthors = Waters N, Hansson L, Löfberg L, Carlsson A | title = Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo | journal = European Journal of Pharmacology | volume = 251 | issue = 2–3 | pages = 181–90 | date = January 1994 | pmid = 8149975 | doi = 10.1016/0014-2999(94)90399-9 }}</ref><ref>{{cite journal | vauthors = Sotnikova TD, Gainetdinov RR, Grekhova TV, Rayevsky KS | title = Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study) | journal = Pharmacological Research | volume = 43 | issue = 3 | pages = 283–90 | date = March 2001 | pmid = 11401421 | doi = 10.1006/phrs.2000.0773 }}</ref><ref>{{cite journal | vauthors = Millan MJ, Seguin L, Gobert A, Cussac D, Brocco M | title = The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats | journal = Psychopharmacology | volume = 174 | issue = 3 | pages = 341–57 | date = July 2004 | pmid = 14985929 | doi = 10.1007/s00213-003-1770-x | s2cid = 1592299 }}</ref> as well as blocking the behavioural effects of cocaine.<ref>{{cite journal | vauthors = Piercey MF, Lum JT, Hoffmann WE, Carlsson A, Ljung E, Svensson K | title = Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232 | journal = Brain Research | volume = 588 | issue = 2 | pages = 217–22 | date = August 1992 | pmid = 1393576 | doi = 10.1016/0006-8993(92)91578-3 | s2cid = 44478271 }}</ref> It may also serve as a [[5-HT2A receptor|5-HT<sub>2A</sub> receptor]] agonist, based on animal studies.<ref name="schiz">{{cite journal | vauthors = Lahti AC, Weiler M, Carlsson A, Tamminga CA | title = Effects of the D3 and autoreceptor-preferring dopamine antagonist (+)-UH232 in schizophrenia | journal = Journal of Neural Transmission | volume = 105 | issue = 6–7 | pages = 719–34 | year = 1998 | pmid = 9826114 | doi = 10.1007/s007020050091 | s2cid = 31976950 }}</ref> It was investigated in clinical trials for the treatment of schizophrenia, but unexpectedly caused symptoms to become worse.<ref name="schiz"/> ==(+)-AJ76== The N-monopropyl derivative (+)-AJ76 is an active metabolite of UH-232 and has practically identical effects. [[Image:(+)-AJ76_structure.png|200px|thumb|left|(+)-AJ76, CAS# 85378-82-1, [https://pubchem.ncbi.nlm.nih.gov/compound/13755572 13755572]]] {{clear-left}} == See also == * [[7-OH-DPAT]] * [[Amisulpride]] * [[RDS-127]] * [[PNU-99,194]] * [[Rotigotine]] * [[UH-302]] == References == {{Reflist}} {{Dopaminergics}} [[Category:2-Aminotetralins]] [[Category:Stimulants]] [[Category:Phenol ethers]] [[Category:Dopamine antagonists]] [[Category:Dopamine agonists]] </textarea><div class="templatesUsed"><div class="mw-templatesUsedExplanation"><p><span id="templatesused">Pages transcluded onto the current version of this page<span class="posteditwindowhelplinks"> (<a href="/wiki/Help:Transclusion" title="Help:Transclusion">help</a>)</span>:</span> </p></div><ul> <li><a href="/wiki/Template:Abbr" title="Template:Abbr">Template:Abbr</a> (<a href="/w/index.php?title=Template:Abbr&action=edit" title="Template:Abbr">view source</a>) (protected)</li><li><a href="/wiki/Template:Button" 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