Touchlight and GSK Partner for Enzymatic dbDNA Production in mRNA Manufacturing

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"2024-07-24T11:27:57+00:00", "description": "Touchlight\n, a contract development and manufacturing organization (CDMO) specializing in enzymatic DNA production,\nhas entered\ninto a licensing agreement with\nGSK\n, a prominent biopharmaceutical company.\nThis collaboration grants GSK non-exclusive rights to utilize Touchlight\u2019s proprietary enzymatic doggybone DNA (dbDNA\u2122) technology for the production of mRNA-based products.", "image": "https://www.biopharmatrend.com/files/blog/social/touchlight.jpg", "url": "https://www.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/", "mainEntityOfPage": { "@type": "WebPage", "@id": "https://www.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/" }, "publisher": { "@type": "Organization", "name": "BiopharmaTrend", "url": "https://www.biopharmatrend.com", "logo": { "@type": "ImageObject", "url": 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class="col-lg-9 col-md-8 col-sm-12 col-xs-12"> <div class="mobile-only"> </div> <article id="post-874" class="post "> <header> <h1>Touchlight and GSK Partner for Enzymatic dbDNA Production in mRNA Manufacturing</h1> </header> <footer class="post-meta"> <div class="tooltip"> <span class="glyphicon glyphicon-pencil"></span> by <a href="/contributor/743/">Roman Kasianov</a> </span>    <span style="white-space: nowrap;"> <span class="glyphicon glyphicon-folder-open"></span>   News </span> <div class="tooltip-text"> <div class="tooltip-close" onclick="this.parentElement.parentElement.classList.toggle('tooltip-show');"></div> <p><b>Disclaimer</b>: All opinions expressed by Contributors are their own and do not represent those of their employers, or BiopharmaTrend.com. <br> Contributors are fully responsible for assuring they own any required copyright for any content they submit to BiopharmaTrend.com. This website and its owners shall not be liable for neither information and content submitted for publication by Contributors, nor its accuracy.</p> </div> </div> <div> <span class="glyphicon glyphicon-calendar" title="Published on"></span> <time datetime="2024-07-24">July 24, 2024</time>    </em> </div> <div class="tags"> <b>Topics: </b> <a href="/topic/biopharma-manufacturing/">Manufacturing & Pharma 4.0</a>    </div> <div> <strong>Share: </strong>   <a target="_blank" rel="nofollow" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in LinkedIn" src="/static/img/soc-in.7bc286fd757e.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.reddit.com/submit?url=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in Reddit" src="/static/img/soc-reddit.342e87a07115.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in X" src="/static/img/soc-x.3c80e8291cba.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://news.ycombinator.com/submitlink?u=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in Hacker News" src="/static/img/soc-y.587f16a5f3f3.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/&display=page"> <img alt="Share in Facebook" src="/static/img/soc-fb.3031a5a810f0.png" width="28" height="28" /></a>  <a target="_blank" rel="nofollow" href="mailto:?subject=Biopharmatrend.com&body=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Send by email" src="/static/img/soc-mail.41ce3608f438.png" width="28" height="28"></a>   |  <a href="/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/pdf/" target="_blank" rel="nofollow"> <span style="vertical-align: text-top; color: deepskyblue; font-size: 1.5em;" class="glyphicon glyphicon-print"></span></a> </div> </footer> <section> <p><a href="https://www.touchlight.com/">Touchlight</a>, a contract development and manufacturing organization (CDMO) specializing in enzymatic DNA production, <a href="https://www.touchlight.com/news/touchlight-and-gsk-sign-license-agreement-for-use-of-enzymatic-dbdna-production-technology-for-mrna-manufacturing/">has entered</a> into a licensing agreement with <a href="https://www.gsk.com">GSK</a>, a prominent biopharmaceutical company.</p> <p>This collaboration grants GSK non-exclusive rights to utilize Touchlight’s proprietary enzymatic doggybone DNA (dbDNA™) technology for the production of mRNA-based products.</p> <center><img src="/files/uploads/2024/07/24/touchlight.jpg" style="max-width: 100%;" /></center> <p style="text-align: center; "><small><em>Multi-gram production in 5 days; Image source: Touchlight</em></small></p> <p>Under the terms of the agreement, GSK will leverage Touchlight's dbDNA technology for the rapid and scalable Good Manufacturing Practice (GMP) production of DNA templates essential for mRNA vaccine development. The financial specifics of the deal remain undisclosed; however, it includes an upfront payment, ongoing technology access fees, milestone payments linked to clinical and regulatory achievements, and royalties on GSK’s mRNA products that incorporate Touchlight’s enzymatic dbDNA.</p> <blockquote> <p>See also: <a href="https://www.biopharmatrend.com/post/386-top-rna-biotech-startups-to-watch-in-2021/">7 Promising RNA Biotech Companies To Watch in 2024</a></p> </blockquote> <p>Touchlight’s dbDNA technology offers a more efficient and scalable alternative to traditional plasmid DNA production by using an enzymatic process to generate high-purity GMP DNA. This is particularly advantageous for mRNA vaccine development, as it allows for the swift and effective production of DNA templates required for mRNA synthesis.</p> <ul> <li>In 2023, Touchlight inaugurated a state-of-the-art production facility capable of producing multi-kilogram quantities of dbDNA. This facility supports numerous client products in clinical development, including three with accepted Investigational New Drug (IND) or Clinical Trial Application (CTA) status.</li> <li>Later in 2024, dbDNA is expected to enter clinical development as an Active Pharmaceutical Ingredient (API) for a therapeutic cancer vaccine, along with multiple other anticipated INDs across various modalities.</li> </ul> <p>Jonny Ohlson, Executive Chair and Founder of Touchlight, emphasized the significance of the partnership, stating:</p> <blockquote> <p>“GSK is a global leader in vaccination, and we are delighted they have licensed our proprietary enzymatic dbDNA™ technology for the development and production of their mRNA-based products. The adoption of Touchlight’s enzymatic DNA is gathering pace and becoming an important part of the advanced therapy supply chain. Our technology delivers the speed, scalability, and high-quality DNA products that are essential for the next generation of mRNA therapeutics.”</p> </blockquote> <div class="product-list"> </div> <p> <b>Topics: </b> <a href="/topic/biopharma-manufacturing/">Manufacturing & Pharma 4.0</a>    </p> </section> </article> <div style="margin: 1em 0 2em; padding: 0.5em 0;"> <strong>Share: </strong>   <a target="_blank" rel="nofollow" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in LinkedIn" src="/static/img/soc-in.7bc286fd757e.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.reddit.com/submit?url=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in Reddit" src="/static/img/soc-reddit.342e87a07115.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in X" src="/static/img/soc-x.3c80e8291cba.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://news.ycombinator.com/submitlink?u=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Share in Hacker News" src="/static/img/soc-y.587f16a5f3f3.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/&display=page"> <img alt="Share in Facebook" src="/static/img/soc-fb.3031a5a810f0.png" width="28" height="28" /></a>  <a target="_blank" rel="nofollow" href="mailto:?subject=Biopharmatrend.com&body=https%3A%2F%2Fwww.biopharmatrend.com/post/874-touchlight-and-gsk-partner-for-enzymatic-dbdna-production-in-mrna-manufacturing/"> <img alt="Send by email" src="/static/img/soc-mail.41ce3608f438.png" width="28" height="28"></a> </div> <div class="subscribe-block"> <div class="subscribe-inner"> <h3 style="line-height:1.5; 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Touchlight and GSK Partner for Enzymatic dbDNA Production in mRNA Manufacturing