CINXE.COM

<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="ABXNkgOq06qry5t8D6Je3xEl8EhCku8hrfJ6ak17HXTZ+FD1ySZ0TYriMpw/n3QNUbIGJD0fCq3dtw3oyvLreQ==" /> <meta name="citation_title" content="The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes" /> <meta name="citation_publication_date" content="2010/01/01" /> <meta name="citation_journal_title" content="Neurochemical Research" /> <meta name="citation_author" content="Silvia Leoncini" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes" /> <meta name="twitter:title" content="The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes" /> <meta name="twitter:description" content="Academia.edu is a platform for academics to share research papers." /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes" /> <meta property="og:title" content="The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes" /> <meta property="article:author" content="https://unisi.academia.edu/SilviaLeoncini" /> <meta name="description" content="The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes" /> <title>(PDF) The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes | Silvia Leoncini - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732393962000); window.Aedu.timeDifference = new Date().getTime() - 1732393962000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":null,"author":[{"@context":"https://schema.org","@type":"Person","name":"Silvia Leoncini"}],"contributor":[],"dateCreated":"2015-07-17","dateModified":null,"datePublished":"2010-01-01","headline":"The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes","inLanguage":"en","keywords":["Calcium","Western blotting","Biological Sciences","Cell line","Humans","Anoxia","Astrocyte","Iron","Phosphorylation","Astrocytes","Mitochondrial dysfunction","Oxygen","Cell Proliferation","Membrane Potential","Mitochondrial Membrane Potential","Adenosine Triphosphate","Neurochemical","Deferoxamine"],"locationCreated":null,"publication":"Neurochemical Research","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"unisi"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> </head> <body> <div id='react-modal'></div> <div class="js-upgrade-ie-banner" style="display: none; text-align: center; padding: 8px 0; background-color: #ebe480;"><p style="color: #000; font-size: 12px; margin: 0 0 4px;">Academia.edu no longer supports Internet Explorer.</p><p style="color: #000; font-size: 12px; margin: 0;">To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.querySelector('.js-upgrade-ie-banner').style.display = 'block'; }</script> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "ffd5ab41922592c07ab58e789d9cc4cbbd0b4a9fcadce509d7eaca6e42de6659", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="cdovf0dPiz/CwUc8e0UVa996bkevR78Yg/aWX8FTRjmoN7IYjcMs2OPo7txLeD+5n+2YK9DKWpTzs+HdRtqwNA==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="KRvVOwXGo3jo9nvkz3UeaDtA94mlUGzANCJZNPohv0nw9khcz0oEn8nf0gT/SDS6e9cB5drdiUxEZy62fahJRA==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><input class="btn btn-primary btn-block g-recaptcha js-password-reset-submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" type="submit" value="Email me a link" /></form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script> <div class="header--container" id="main-header-container"><div class="header--inner-container header--inner-container-ds2"><div class="header-ds2--left-wrapper"><div class="header-ds2--left-wrapper-inner"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="hide-on-desktop-redesign" style="height: 24px; width: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hide-on-mobile-redesign" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a><div class="header--search-container header--search-container-ds2"><form class="js-SiteSearch-form select2-no-default-pills" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><svg style="width: 14px; height: 14px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="search" class="header--search-icon svg-inline--fa fa-search fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><input class="header--search-input header--search-input-ds2 js-SiteSearch-form-input" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" /></form></div></div></div><nav class="header--nav-buttons header--nav-buttons-ds2 js-main-nav"><a class="ds2-5-button ds2-5-button--secondary js-header-login-url header-button-ds2 header-login-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/login" rel="nofollow">Log In</a><a class="ds2-5-button ds2-5-button--secondary header-button-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a><button class="header--hamburger-button header--hamburger-button-ds2 hide-on-desktop-redesign js-header-hamburger-button"><div class="icon-bar"></div><div class="icon-bar" style="margin-top: 4px;"></div><div class="icon-bar" style="margin-top: 4px;"></div></button></nav></div><ul class="header--dropdown-container js-header-dropdown"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/login" rel="nofollow">Log In</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a></li><li class="header--dropdown-row js-header-dropdown-expand-button"><button class="header--dropdown-button">more<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-down" class="header--dropdown-button-icon svg-inline--fa fa-caret-down fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z"></path></svg></button></li><li><ul class="header--expanded-dropdown-container"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/about">About</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/press">Press</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://medium.com/@academia">Blog</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/documents">Papers</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/terms">Terms</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/privacy">Privacy</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/copyright">Copyright</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/hiring"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="header--dropdown-row-icon svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg>We're Hiring!</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://support.academia.edu/"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="header--dropdown-row-icon svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg>Help Center</a></li><li class="header--dropdown-row js-header-dropdown-collapse-button"><button class="header--dropdown-button">less<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-up" class="header--dropdown-button-icon svg-inline--fa fa-caret-up fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-bf3d831cde46cd0e142f29f81a3fc4ce5ab45a404c10c12a480e83de68aff851.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 33132803; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F14141057%2FThe_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F14141057%2FThe_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":44567584,"identifier":"Attachment_44567584","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":14141057,"created_at":"2015-07-17T00:44:28.359-07:00","from_world_paper_id":139664443,"updated_at":"2024-11-13T06:29:12.890-08:00","_data":{"grobid_abstract":"Nerve cells are very susceptible to hypoxia responsive for mitochondrial dysfunctions involved in the subsequent oxidative stress, apoptosis and necrosis. In this paper, we examined the effect of 12 h incubation of U-373 MG astrocytes in hypoxic environment (73% N 2 : 2% O 2 : 5% CO 2 , v:v) by evaluating cell proliferation, modifications of NO and ATP production, intracellular Ca 2? concentration [Ca 2? ] i , membrane potential, desferoxaminechelatable free iron, esterified F2-isoprostanes levels and the production of phosphorylated ERK. The same parameters were evaluated also after a following re-oxygenation period of 24 h. Immediately after hypoxia the NO concentration increased significantly and returned to values similar to those of controls after the re-oxygenation period. At the same time, ATP levels remained similar to controls and the cell proliferation significantly decreased. This involved a significant increase of [Ca 2? ] i immediately after hypoxia and the value remained significantly elevated after the following re-oxygenation period. Moreover, after hypoxia, astrocytes were slightly although not significantly depolarized. Indeed iron and F2-isoprostanes levels increased significantly after hypoxia. Finally ERK proteins increased slowly and not significantly after hypoxia and the same trend was observed after the re-oxygenation period.","publication_date":"2010,,","publication_name":"Neurochemical Research","grobid_abstract_attachment_id":"44567584"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33132803]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":44567584,"attachmentType":"pdf"}"><img alt="First page of “The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/44567584/mini_magick20190214-16641-m161cm.png?1550154729" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">The Effects of Hypoxia/Reoxygenation on the Physiological Behaviour of U373-Mg Astrocytes</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="33132803" href="https://unisi.academia.edu/SilviaLeoncini"><img alt="Profile image of Silvia Leoncini" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Silvia Leoncini</a></div><p class="ds-work-card--detail ds2-5-body-sm">2010, Neurochemical Research</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":44567584,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":44567584,"attachmentType":"pdf","workUrl":"https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="44567584" data-landing_url="https://www.academia.edu/14141057/The_Effects_of_Hypoxia_Reoxygenation_on_the_Physiological_Behaviour_of_U373_Mg_Astrocytes" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="13889485" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13889485/The_Physiological_Behaviour_of_IMR_32_Neuroblastoma_Cells_is_Affected_by_a_12_h_Hypoxia_24_h_Reoxygenation_Period">The Physiological Behaviour of IMR-32 Neuroblastoma Cells is Affected by a 12-h Hypoxia/24-h Reoxygenation Period</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32963058" href="https://ferrara.academia.edu/GiuseppeValacchi">Giuseppe Valacchi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemical Research, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Physiological Behaviour of IMR-32 Neuroblastoma Cells is Affected by a 12-h Hypoxia/24-h Reoxygenation Period","attachmentId":44833318,"attachmentType":"pdf","work_url":"https://www.academia.edu/13889485/The_Physiological_Behaviour_of_IMR_32_Neuroblastoma_Cells_is_Affected_by_a_12_h_Hypoxia_24_h_Reoxygenation_Period","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13889485/The_Physiological_Behaviour_of_IMR_32_Neuroblastoma_Cells_is_Affected_by_a_12_h_Hypoxia_24_h_Reoxygenation_Period"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="55863887" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55863887/Oxidative_stress_and_apoptosis_after_acute_respiratory_hypoxia_and_reoxygenation_in_rat_brain">Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1250015" href="https://ub.academia.edu/TeresaCarbonell">Teresa Carbonell</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Redox Biology, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain","attachmentId":71531851,"attachmentType":"pdf","work_url":"https://www.academia.edu/55863887/Oxidative_stress_and_apoptosis_after_acute_respiratory_hypoxia_and_reoxygenation_in_rat_brain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55863887/Oxidative_stress_and_apoptosis_after_acute_respiratory_hypoxia_and_reoxygenation_in_rat_brain"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="98450841" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/98450841/Effects_of_hypoxia_and_reoxygenation_on_mitochondrial_functions_and_transcriptional_profiles_of_isolated_brain_and_muscle_porcine_cells">Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5415412" href="https://uncc.academia.edu/InnaSokolova">Inna Sokolova</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Scientific Reports</p><p class="ds-related-work--abstract ds2-5-body-sm">Oxygen fluctuations might occur in mammalian tissues under physiological (e.g. at high altitudes) or pathological (e.g. ischemia–reperfusion) conditions. Mitochondria are the key target and potential amplifiers of hypoxia-reoxygenation (H-R) stress. Understanding the mitochondrial responses to H-R stress is important for identifying adaptive mechanisms and potential therapeutic solutions for pathologies associated with oxygen fluctuations. We explored metabolic response to H-R stress in two tissue types (muscle and brain) with different degrees of hypoxia tolerance in a domestic pig Sus scrofa focusing on the cellular responses independent of the systemic regulatory mechanisms. Isolated cells from the skeletal muscle (masseter) and brain (thalamus) were exposed to acute short-term (15 min) hypoxia followed by reoxygenation. The mitochondrial oxygen consumption, reactive oxygen species (ROS) production rates and transcriptional profiles of hypoxia-responsive mRNA and miRNA were deter...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells","attachmentId":99798368,"attachmentType":"pdf","work_url":"https://www.academia.edu/98450841/Effects_of_hypoxia_and_reoxygenation_on_mitochondrial_functions_and_transcriptional_profiles_of_isolated_brain_and_muscle_porcine_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/98450841/Effects_of_hypoxia_and_reoxygenation_on_mitochondrial_functions_and_transcriptional_profiles_of_isolated_brain_and_muscle_porcine_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="26106915" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26106915/Hypoxia_and_Neuronal_Function_under_in_Vitro_Conditions">Hypoxia and Neuronal Function under in Vitro Conditions</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49946980" href="https://independent.academia.edu/KarenNieber">Karen Nieber</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pharmacology & Therapeutics, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia and Neuronal Function under in Vitro Conditions","attachmentId":46455659,"attachmentType":"pdf","work_url":"https://www.academia.edu/26106915/Hypoxia_and_Neuronal_Function_under_in_Vitro_Conditions","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26106915/Hypoxia_and_Neuronal_Function_under_in_Vitro_Conditions"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="60526912" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60526912/Mitochondrial_damage_and_metabolic_compensatory_mechanisms_induced_by_hyperoxia_in_the_U_937_cell_line">Mitochondrial damage and metabolic compensatory mechanisms induced by hyperoxia in the U-937 cell line</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16878460" href="https://independent.academia.edu/RobertoScatena">Roberto Scatena</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of biochemistry and molecular biology, 2004</p><p class="ds-related-work--abstract ds2-5-body-sm">Experimental hyperoxia represents a suitable in vitro model to study some pathogenic mechanisms related to oxidative stress. Moreover, it allows the investigation of the molecular pathophysiology underlying oxygen therapy and toxicity. In this study, a modified experimental set up was adopted to accomplish a model of moderate hyperoxia (50% O(2), 96 h culture) to induce oxidative stress in the human leukemia cell line, U-937. Spectrophotometric measurements of mitochondrial respiratory enzyme activities, NMR spectroscopy of culture media, determination of antioxidant enzyme activities, and cell proliferation and differentiation assays were performed. The data showed that moderate hyperoxia in this myeloid cell line causes: i) intriguing alterations in the mitochondrial activities at the levels of succinate dehydrogenase and succinate-cytochrome c reductase; ii) induction of metabolic compensatory adaptations, with significant shift to glycolysis; iii) induction of different antioxid...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitochondrial damage and metabolic compensatory mechanisms induced by hyperoxia in the U-937 cell line","attachmentId":73932436,"attachmentType":"pdf","work_url":"https://www.academia.edu/60526912/Mitochondrial_damage_and_metabolic_compensatory_mechanisms_induced_by_hyperoxia_in_the_U_937_cell_line","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/60526912/Mitochondrial_damage_and_metabolic_compensatory_mechanisms_induced_by_hyperoxia_in_the_U_937_cell_line"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="21063738" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21063738/The_Effect_of_Mild_and_Severe_Hypoxia_on_Rat_Cortical_Synaptosomes">The Effect of Mild and Severe Hypoxia on Rat Cortical Synaptosomes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42285807" href="https://unisi.academia.edu/CarloAldinucci">Carlo Aldinucci</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemical Research, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Effect of Mild and Severe Hypoxia on Rat Cortical Synaptosomes","attachmentId":41697072,"attachmentType":"pdf","work_url":"https://www.academia.edu/21063738/The_Effect_of_Mild_and_Severe_Hypoxia_on_Rat_Cortical_Synaptosomes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/21063738/The_Effect_of_Mild_and_Severe_Hypoxia_on_Rat_Cortical_Synaptosomes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="22294350" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22294350/Effect_of_Hyperoxia_on_Cortical_Neuronal_Nuclear_Function_and_Programmed_Cell_Death_Mechanisms">Effect of Hyperoxia on Cortical Neuronal Nuclear Function and Programmed Cell Death Mechanisms</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43696864" href="https://drexelmed.academia.edu/MariaDelivoriapapadopoulos">Maria Delivoria-papadopoulos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemical Research, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Hyperoxia on Cortical Neuronal Nuclear Function and Programmed Cell Death Mechanisms","attachmentId":42938988,"attachmentType":"pdf","work_url":"https://www.academia.edu/22294350/Effect_of_Hyperoxia_on_Cortical_Neuronal_Nuclear_Function_and_Programmed_Cell_Death_Mechanisms","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22294350/Effect_of_Hyperoxia_on_Cortical_Neuronal_Nuclear_Function_and_Programmed_Cell_Death_Mechanisms"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="62247505" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62247505/Intermittent_Hypobaric_Hypoxic_Preconditioning_Provides_Neuroprotection_by_Increasing_Antioxidant_Activity_Erythropoietin_Expression_and_Preventing_Apoptosis_and_Astrogliosis_in_the_Brain_of_Adult_Rats_Exposed_to_Acute_Severe_Hypoxia">Intermittent Hypobaric Hypoxic Preconditioning Provides Neuroprotection by Increasing Antioxidant Activity, Erythropoietin Expression and Preventing Apoptosis and Astrogliosis in the Brain of Adult Rats Exposed to Acute Severe Hypoxia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42011138" href="https://independent.academia.edu/JoanRamonTorrella">Joan Ramon Torrella</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Molecular Sciences</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Exposure to intermittent hypoxia has been demonstrated to be an efficient tool for hypoxic preconditioning, preventing damage to cells and demonstrating therapeutic benefits. We aimed to evaluate the effects of respiratory intermittent hypobaric hypoxia (IHH) to avoid brain injury caused by exposure to acute severe hypoxia (ASH). Methods: biomarkers of oxidative damage, mitochondrial apoptosis, and transcriptional factors in response to hypoxia were assessed by Western blot and immunohistochemistry in brain tissue. Four groups of rats were used: (1) normoxic (NOR), (2) exposed to ASH (FiO2 7% for 6 h), (3) exposed to IHH for 3 h per day over 8 days at 460 mmHg, and (4) ASH preconditioned after IHH. Results: ASH animals underwent increased oxidative-stress-related parameters, an upregulation in apoptotic proteins and had astrocytes with phenotype forms compatible with severe diffuse reactive astrogliosis. These effects were attenuated and even prevented when the animals w...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intermittent Hypobaric Hypoxic Preconditioning Provides Neuroprotection by Increasing Antioxidant Activity, Erythropoietin Expression and Preventing Apoptosis and Astrogliosis in the Brain of Adult Rats Exposed to Acute Severe Hypoxia","attachmentId":75075513,"attachmentType":"pdf","work_url":"https://www.academia.edu/62247505/Intermittent_Hypobaric_Hypoxic_Preconditioning_Provides_Neuroprotection_by_Increasing_Antioxidant_Activity_Erythropoietin_Expression_and_Preventing_Apoptosis_and_Astrogliosis_in_the_Brain_of_Adult_Rats_Exposed_to_Acute_Severe_Hypoxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/62247505/Intermittent_Hypobaric_Hypoxic_Preconditioning_Provides_Neuroprotection_by_Increasing_Antioxidant_Activity_Erythropoietin_Expression_and_Preventing_Apoptosis_and_Astrogliosis_in_the_Brain_of_Adult_Rats_Exposed_to_Acute_Severe_Hypoxia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="55548475" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55548475/Hypoxia_and_mitochondrial_oxidative_metabolism">Hypoxia and mitochondrial oxidative metabolism</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32627530" href="https://independent.academia.edu/ABaracca">A. Baracca</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia and mitochondrial oxidative metabolism","attachmentId":71370373,"attachmentType":"pdf","work_url":"https://www.academia.edu/55548475/Hypoxia_and_mitochondrial_oxidative_metabolism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55548475/Hypoxia_and_mitochondrial_oxidative_metabolism"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="81909204" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81909204/Mechanisms_of_hypoxic_cell_injury">Mechanisms of hypoxic cell injury</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36188156" href="https://independent.academia.edu/HartmutJaeschke">Hartmut Jaeschke</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Toxicology and Applied Pharmacology, 1990</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mechanisms of hypoxic cell injury","attachmentId":87788151,"attachmentType":"pdf","work_url":"https://www.academia.edu/81909204/Mechanisms_of_hypoxic_cell_injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81909204/Mechanisms_of_hypoxic_cell_injury"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":44567584,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":44567584,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_44567584" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="13749634" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13749634/Decreased_rat_brain_cytochrome_oxidase_activity_after_prolonged_hypoxia">Decreased rat brain cytochrome oxidase activity after prolonged hypoxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32868221" href="https://case.academia.edu/JosephLamanna">Joseph C LaManna</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Decreased rat brain cytochrome oxidase activity after prolonged hypoxia","attachmentId":44996050,"attachmentType":"pdf","work_url":"https://www.academia.edu/13749634/Decreased_rat_brain_cytochrome_oxidase_activity_after_prolonged_hypoxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13749634/Decreased_rat_brain_cytochrome_oxidase_activity_after_prolonged_hypoxia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="14141046" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14141046/Hypoxia_affects_the_physiological_behavior_of_rat_cortical_synaptosomes">Hypoxia affects the physiological behavior of rat cortical synaptosomes</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33132803" href="https://unisi.academia.edu/SilviaLeoncini">Silvia Leoncini</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Free Radical Biology and Medicine, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia affects the physiological behavior of rat cortical synaptosomes","attachmentId":44567603,"attachmentType":"pdf","work_url":"https://www.academia.edu/14141046/Hypoxia_affects_the_physiological_behavior_of_rat_cortical_synaptosomes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/14141046/Hypoxia_affects_the_physiological_behavior_of_rat_cortical_synaptosomes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="71285345" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71285345/NMR_spectroscopic_study_of_cell_cultures_of_astrocytes_and_neurons_exposed_to_hypoxia_compartmentation_of_astrocyte_metabolism">NMR spectroscopic study of cell cultures of astrocytes and neurons exposed to hypoxia: compartmentation of astrocyte metabolism</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2807349" href="https://aalborg.academia.edu/SteffenBPetersen">Steffen B Petersen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemistry …, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"NMR spectroscopic study of cell cultures of astrocytes and neurons exposed to hypoxia: compartmentation of astrocyte metabolism","attachmentId":80695751,"attachmentType":"pdf","work_url":"https://www.academia.edu/71285345/NMR_spectroscopic_study_of_cell_cultures_of_astrocytes_and_neurons_exposed_to_hypoxia_compartmentation_of_astrocyte_metabolism","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/71285345/NMR_spectroscopic_study_of_cell_cultures_of_astrocytes_and_neurons_exposed_to_hypoxia_compartmentation_of_astrocyte_metabolism"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="21063728" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21063728/Potentiation_of_intracellular_Ca2_mobilization_by_hypoxia_induced_NO_generation_in_rat_brain_striatal_slices_and_human_astrocytoma_U_373_MG_cells_and_its_involvement_in_tissue_damage">Potentiation of intracellular Ca2+ mobilization by hypoxia-induced NO generation in rat brain striatal slices and human astrocytoma U-373 MG cells and its involvement in tissue damage</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42285807" href="https://unisi.academia.edu/CarloAldinucci">Carlo Aldinucci</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Neuroscience, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Potentiation of intracellular Ca2+ mobilization by hypoxia-induced NO generation in rat brain striatal slices and human astrocytoma U-373 MG cells and its involvement in tissue damage","attachmentId":41697074,"attachmentType":"pdf","work_url":"https://www.academia.edu/21063728/Potentiation_of_intracellular_Ca2_mobilization_by_hypoxia_induced_NO_generation_in_rat_brain_striatal_slices_and_human_astrocytoma_U_373_MG_cells_and_its_involvement_in_tissue_damage","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21063728/Potentiation_of_intracellular_Ca2_mobilization_by_hypoxia_induced_NO_generation_in_rat_brain_striatal_slices_and_human_astrocytoma_U_373_MG_cells_and_its_involvement_in_tissue_damage"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="64185226" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/64185226/Chapter_3_The_Hypoxia_Reoxygenation_Injury_Model">Chapter 3 The Hypoxia-Reoxygenation Injury Model</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34613600" href="https://exeter.academia.edu/DomokosGer%C5%91">Domokos Gerő</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Chapter 3 The Hypoxia-Reoxygenation Injury Model","attachmentId":76337587,"attachmentType":"pdf","work_url":"https://www.academia.edu/64185226/Chapter_3_The_Hypoxia_Reoxygenation_Injury_Model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/64185226/Chapter_3_The_Hypoxia_Reoxygenation_Injury_Model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="70661943" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/70661943/Article_Antioxidant_and_Protective_Mechanisms_against_Hypoxia_and_Hypoglycaemia_in_Cortical_Neurons_in_Vitro">Article Antioxidant and Protective Mechanisms against Hypoxia and Hypoglycaemia in Cortical Neurons in Vitro</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5304581" href="https://independent.academia.edu/C%C3%A9sarRoncero">César Roncero</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Article Antioxidant and Protective Mechanisms against Hypoxia and Hypoglycaemia in Cortical Neurons in Vitro","attachmentId":80319467,"attachmentType":"pdf","work_url":"https://www.academia.edu/70661943/Article_Antioxidant_and_Protective_Mechanisms_against_Hypoxia_and_Hypoglycaemia_in_Cortical_Neurons_in_Vitro","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/70661943/Article_Antioxidant_and_Protective_Mechanisms_against_Hypoxia_and_Hypoglycaemia_in_Cortical_Neurons_in_Vitro"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="10480796" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/10480796/Respiratory_Hypoxia_and_Oxidative_Stress_in_the_Brain_Is_the_Endogenous_Erythropoietin_an_Antioxidant">Respiratory Hypoxia and Oxidative Stress in the Brain. Is the Endogenous Erythropoietin an Antioxidant?</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="1250015" href="https://ub.academia.edu/TeresaCarbonell">Teresa Carbonell</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Current Chemical Biology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Respiratory Hypoxia and Oxidative Stress in the Brain. Is the Endogenous Erythropoietin an Antioxidant?","attachmentId":47361015,"attachmentType":"pdf","work_url":"https://www.academia.edu/10480796/Respiratory_Hypoxia_and_Oxidative_Stress_in_the_Brain_Is_the_Endogenous_Erythropoietin_an_Antioxidant","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/10480796/Respiratory_Hypoxia_and_Oxidative_Stress_in_the_Brain_Is_the_Endogenous_Erythropoietin_an_Antioxidant"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="25238796" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25238796/Mechanisms_of_oxidative_stress_resistance_in_the_brain_Lessons_learned_from_hypoxia_tolerant_extremophilic_vertebrates">Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48577827" href="https://independent.academia.edu/KarlRodriguez1">Karl Rodriguez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Biochemistry and Biophysics, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates","attachmentId":45545111,"attachmentType":"pdf","work_url":"https://www.academia.edu/25238796/Mechanisms_of_oxidative_stress_resistance_in_the_brain_Lessons_learned_from_hypoxia_tolerant_extremophilic_vertebrates","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/25238796/Mechanisms_of_oxidative_stress_resistance_in_the_brain_Lessons_learned_from_hypoxia_tolerant_extremophilic_vertebrates"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="57611670" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57611670/Antioxidant_and_Protective_Mechanisms_against_Hypoxia_and_Hypoglycaemia_in_Cortical_Neurons_in_Vitro">Antioxidant and Protective Mechanisms against Hypoxia and Hypoglycaemia in Cortical Neurons in Vitro</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="201776691" href="https://independent.academia.edu/Jos%C3%A9Merino12">José Merino</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Molecular Sciences, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Antioxidant and Protective Mechanisms against Hypoxia and Hypoglycaemia in Cortical Neurons in Vitro","attachmentId":72428534,"attachmentType":"pdf","work_url":"https://www.academia.edu/57611670/Antioxidant_and_Protective_Mechanisms_against_Hypoxia_and_Hypoglycaemia_in_Cortical_Neurons_in_Vitro","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/57611670/Antioxidant_and_Protective_Mechanisms_against_Hypoxia_and_Hypoglycaemia_in_Cortical_Neurons_in_Vitro"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="79589730" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79589730/Separate_and_combined_effects_of_a_10_d_exposure_to_hypoxia_and_inactivity_on_oxidative_function_in_vivo_and_mitochondrial_respiration_ex_vivo_in_humans">Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34322848" href="https://uniud.academia.edu/IreneMavelli">Irene Mavelli</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Applied Physiology, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans","attachmentId":86252647,"attachmentType":"pdf","work_url":"https://www.academia.edu/79589730/Separate_and_combined_effects_of_a_10_d_exposure_to_hypoxia_and_inactivity_on_oxidative_function_in_vivo_and_mitochondrial_respiration_ex_vivo_in_humans","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/79589730/Separate_and_combined_effects_of_a_10_d_exposure_to_hypoxia_and_inactivity_on_oxidative_function_in_vivo_and_mitochondrial_respiration_ex_vivo_in_humans"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="53842379" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53842379/Altered_cellular_redox_homeostasis_and_redox_responses_under_standard_oxygen_cell_culture_conditions_versus_physioxia">Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20039422" href="https://ddrc.academia.edu/GarySmerdon">Gary Smerdon</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Free radical biology & medicine, 2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia","attachmentId":70494529,"attachmentType":"pdf","work_url":"https://www.academia.edu/53842379/Altered_cellular_redox_homeostasis_and_redox_responses_under_standard_oxygen_cell_culture_conditions_versus_physioxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/53842379/Altered_cellular_redox_homeostasis_and_redox_responses_under_standard_oxygen_cell_culture_conditions_versus_physioxia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="24370011" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24370011/Cellular_adaptive_responses_to_low_oxygen_tension_apoptosis_and_resistance">Cellular adaptive responses to low oxygen tension: apoptosis and resistance</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46980636" href="https://independent.academia.edu/ThomasMcCormick8">Thomas McCormick</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemical research, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cellular adaptive responses to low oxygen tension: apoptosis and resistance","attachmentId":44700728,"attachmentType":"pdf","work_url":"https://www.academia.edu/24370011/Cellular_adaptive_responses_to_low_oxygen_tension_apoptosis_and_resistance","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/24370011/Cellular_adaptive_responses_to_low_oxygen_tension_apoptosis_and_resistance"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="17870711" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17870711/Oxygen_insufficiency_during_hypoxic_hypoxia_in_rat_brain_cortex">Oxygen insufficiency during hypoxic hypoxia in rat brain cortex</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32868221" href="https://case.academia.edu/JosephLamanna">Joseph C LaManna</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research, 1984</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oxygen insufficiency during hypoxic hypoxia in rat brain cortex","attachmentId":39754669,"attachmentType":"pdf","work_url":"https://www.academia.edu/17870711/Oxygen_insufficiency_during_hypoxic_hypoxia_in_rat_brain_cortex","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/17870711/Oxygen_insufficiency_during_hypoxic_hypoxia_in_rat_brain_cortex"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="90795667" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia">Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47968559" href="https://marshfieldclinic.academia.edu/JaimeBoero">Jaime Boero</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neuroscience Letters, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia","attachmentId":94260089,"attachmentType":"pdf","work_url":"https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="6655282" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/6655282/Hypoxic_pretreatment_protects_against_neuronal_damage_of_the_rat_hippocampus_induced_by_severe_hypoxia">Hypoxic pretreatment protects against neuronal damage of the rat hippocampus induced by severe hypoxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10802105" href="https://independent.academia.edu/nikosgorgias">nikos gorgias</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxic pretreatment protects against neuronal damage of the rat hippocampus induced by severe hypoxia","attachmentId":48765362,"attachmentType":"pdf","work_url":"https://www.academia.edu/6655282/Hypoxic_pretreatment_protects_against_neuronal_damage_of_the_rat_hippocampus_induced_by_severe_hypoxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/6655282/Hypoxic_pretreatment_protects_against_neuronal_damage_of_the_rat_hippocampus_induced_by_severe_hypoxia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="112984254" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/112984254/Effect_of_Long_Term_Normobaric_Hyperoxia_on_Oxidative_Stress_in_Mitochondria_of_the_Guinea_Pig_Brain">Effect of Long-Term Normobaric Hyperoxia on Oxidative Stress in Mitochondria of the Guinea Pig Brain</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35663563" href="https://comeniusuniversity.academia.edu/JanLehotsk%C3%BD">Jan Lehotský</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurochemical Research, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of Long-Term Normobaric Hyperoxia on Oxidative Stress in Mitochondria of the Guinea Pig Brain","attachmentId":110067278,"attachmentType":"pdf","work_url":"https://www.academia.edu/112984254/Effect_of_Long_Term_Normobaric_Hyperoxia_on_Oxidative_Stress_in_Mitochondria_of_the_Guinea_Pig_Brain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/112984254/Effect_of_Long_Term_Normobaric_Hyperoxia_on_Oxidative_Stress_in_Mitochondria_of_the_Guinea_Pig_Brain"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="9534" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="37834" href="https://www.academia.edu/Documents/in/Western_blotting">Western blotting</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="57808" href="https://www.academia.edu/Documents/in/Cell_line">Cell line</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="67133" href="https://www.academia.edu/Documents/in/Anoxia">Anoxia</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="130116" href="https://www.academia.edu/Documents/in/Astrocyte">Astrocyte</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="158597" href="https://www.academia.edu/Documents/in/Iron">Iron</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="172083" href="https://www.academia.edu/Documents/in/Phosphorylation">Phosphorylation</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="196442" href="https://www.academia.edu/Documents/in/Astrocytes">Astrocytes</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="280879" href="https://www.academia.edu/Documents/in/Mitochondrial_dysfunction">Mitochondrial dysfunction</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="380825" href="https://www.academia.edu/Documents/in/Oxygen">Oxygen</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="782251" href="https://www.academia.edu/Documents/in/Cell_Proliferation">Cell Proliferation</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="887736" href="https://www.academia.edu/Documents/in/Membrane_Potential">Membrane Potential</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1148360" href="https://www.academia.edu/Documents/in/Mitochondrial_Membrane_Potential">Mitochondrial Membrane Potential</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1816594" href="https://www.academia.edu/Documents/in/Adenosine_Triphosphate">Adenosine Triphosphate</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1991090" href="https://www.academia.edu/Documents/in/Neurochemical">Neurochemical</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="2397637" href="https://www.academia.edu/Documents/in/Deferoxamine">Deferoxamine</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div> </body> </html>