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data-dom-id="Pill-react-component-2e24dc3a-7ae4-4321-a5c0-122e3828d3f7"></div> <div id="Pill-react-component-2e24dc3a-7ae4-4321-a5c0-122e3828d3f7"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Rachel Miller</h3></div><div class="js-work-strip profile--work_container" data-work-id="27537966"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27537966/Effects_of_Ambient_Nickel_Vanadium_and_Zinc_on_Wheeze_and_Cough_in_Early_Childhood"><img alt="Research paper thumbnail of Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early Childhood" class="work-thumbnail" src="https://attachments.academia-assets.com/47791694/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27537966/Effects_of_Ambient_Nickel_Vanadium_and_Zinc_on_Wheeze_and_Cough_in_Early_Childhood">Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early Childhood</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RobinGarfinkel">Robin Garfinkel</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/StevenChillrud">Steven Chillrud</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="522e0549527328af509efbef93bf7d45" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47791694,"asset_id":27537966,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47791694/download_file?st=MTczMjQwNjI0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: 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var workId = 27537966; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27537966']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27537966, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "522e0549527328af509efbef93bf7d45" } } $('.js-work-strip[data-work-id=27537966]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27537966,"title":"Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early Childhood","translated_title":"","metadata":{"grobid_abstract":"RATIONALE: ETS is known to be an important aggravating factor in asthma. Children is commonly exposed to passive smoking. We determined whether ETS have influence on the sputum concentration of VEGF in asthmatic children. METHODS:75 asthmatic children were enrolled, who were hospitalized with asthma symptom in Geoje Baek Hospital. We measured the urinary cotinine concentrations of asthma children patient for assessment of passive smoking. 75 asthmatic children were classified as ETS group(n 5 32) and non-ETS group(n 5 43). We measured VEGF levels in induced sputum from asthmatic children patient. We compared the sputum VEGF levels of 2 groups. RESULTS: Asthmatic children of ETS group showed higher sputum VEGF levels than those of non-ETS group (683.1 6 62.3 ng/mL vs. 241.6 6 38.4 ng/mL) (p 5 0.004). CONCLUSIONS: When asthmatic children were exposed to familial passive smoking, the higher levels of VEGF were measured in their sputum. We may suggest the possibility of improving illness by reducing exposure to ETS. RATIONALE: Despite well-documented associations between traffic-related pollutants such as PM2.5 and NOx and asthma outcomes, effects of trace elements have not been fully characterized. Our objectives were to examine temporal associations between airborne levels of individual metals, including nickel, vanadium, and zinc, and longitudinal reports of respiratory symptoms in children through age 24 months. METHODS: The study population included participants from the Columbia Center for Children's Environmental Health birth cohort. Data on presence and number of days of wheeze or cough were collected by questionnaire every 3 months, between 3 and 24 months of age. Ambient metals concentrations were obtained for monitoring sites operated by the New York State Department of Environmental Conservation and located within the study area. For each subject, 3-month average concentrations of nickel, vanadium, and zinc were calculated for each symptom reporting period based on the questionnaire date and the preceding 3 months. Associations between metals and symptoms were characterized using mixed models, adjusting for sex, ethnicity, environmental tobacco smoke exposure, and cold/flu season. RESULTS: Increases in ambient concentrations of nickel, vanadium, and zinc were significantly associated with increased probability of wheeze and cough. Increases in metals also were significantly associated with increases in the number of days of symptoms, possibly indicating greater severity of symptoms resulting from higher metals exposures. CONCLUSIONS: These results suggest that increases in ambient concentrations of traffic-related metals may be associated with increased probability of respiratory symptoms in young, inner city children. The findings highlight the need for measurement of specific traffic-related air pollution components. RATIONALE: Stachybotrys chartarum is a mold associated with waterdamaged buildings that can produce mycotoxins. Reliable methods for assessment of exposure to molds are critical to determine risks associated with mold exposure. Our aim was to develop sensitive immunoassays using ELISA and fluorescent multiplex array technology for the detection of S. chartarum antigen. METHODS: Extracts of 13 isolates of S. chartarum as well as of 10 other mold species commonly found in water-damaged buildings were screened using ELISA for Sch34 antigen (see JIM 332: 2008). These extracts were also tested by fluorescent multiplex array using monoclonal antibodies covalently coupled to internally labeled microspheres. A panel of 5 newly developed monoclonal anti-S. chartarum antibodies was tested against mold extracts to determine species-specificity. RESULTS: The ELISA and multiplex array for Sch34 antigen did not cross-react with the 10 mold species tested and were shown to be specific for S. chartarum and S. chlorohalonata. Both assays exhibited high levels of sensitivity: Dynamic ranges were 6-0.38ng/ml for ELISA and 6-0.01ng/ ml for the fluorescent multiplex array. Results between ELISA and multiplex array were closely correlated (r 5 0.99, n 5 16). The 5 newly developed monoclonal antibodies were also found to be species-specific for S. chartarum. CONCLUSIONS: We have developed species-specific and highly sensitive assays for S. chartarum antigen using monoclonal antibody-based ELISA and fluorescent multiplex array. The data suggest that murine antibody responses to S. chartarum tend to be species specific and/or that S. chartarum produces unique antigens. RATIONALE: The effects of air conditioner filter on the removal of airborne indoor allergens, especially house dust mite, are still controversial. 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OUTCOME MEASURES TO ASSESS PEDIATRIC LUNG HEALTH</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20038908"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20038908"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20038908; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20038908]").text(description); $(".js-view-count[data-work-id=20038908]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20038908; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20038908']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20038908, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20038908]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20038908,"title":"Association Between Prenatal Home Cockroach Allergen Levels And Fractional Exhaled Nitric Oxide At Age 5-11 Years","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"B107. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26984693"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26984693/The_Impact_of_Bisphenol_A_and_Phthalates_on_Allergy_Asthma_and_Immune_Function_a_Review_of_Latest_Findings"><img alt="Research paper thumbnail of The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26984693/The_Impact_of_Bisphenol_A_and_Phthalates_on_Allergy_Asthma_and_Immune_Function_a_Review_of_Latest_Findings">The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings</a></div><div class="wp-workCard_item"><span>Current environmental health reports</span><span>, Jan 4, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In recent years, the impact of environmental exposure to chemicals and their immunological effect...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine-disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, is ubiquitous. The links between their exposure and the development of allergy, asthma, and immune dysfunction have been studied in vitro, in vivo, and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy, and asthma after dietary and inhalation exposure to these chemicals, may be occurring.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984693"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984693"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984693; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984693]").text(description); $(".js-view-count[data-work-id=26984693]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984693; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984693']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984693, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26984693]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984693,"title":"The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings","translated_title":"","metadata":{"abstract":"In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. 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However, data regarding the incidence and prevalence of anaphylaxis and the number of deaths caused by it are limited. To provide a better understanding of the magnitude of the problem of anaphylaxis in the United States. A thorough review of the current medical literature was conducted to obtain prevalence estimates on each of the 4 major subtypes of anaphylaxis (food, drugs, latex, and insect stings). We calculated an overall estimate of the risk of anaphylaxis by using only estimates that are specifically derived from epidemiologic studies measuring anaphylaxis in the general population. Known rates or cases of anaphylaxis were 0.0004% for food, 0.7% to 10% for penicillin, 0. 22% to 1% for radiocontrast media, and 0.5% to 5% after insect stings. There were 220 cases after latex exposure. Considering the 1999 US population of 272 million, the population at risk f...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a784ce220029b9f1081d437d771a4599" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47246538,"asset_id":26984692,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47246538/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984692"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984692"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984692; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984692]").text(description); $(".js-view-count[data-work-id=26984692]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984692; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984692']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984692, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a784ce220029b9f1081d437d771a4599" } } $('.js-work-strip[data-work-id=26984692]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984692,"title":"Anaphylaxis in the United States: an investigation into its epidemiology","translated_title":"","metadata":{"abstract":"Anaphylaxis is a severe, life-threatening allergic reaction that affects both children and adults in the United States. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26984691"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26984691/cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma"><img alt="Research paper thumbnail of cFLIP expression is altered in severe corticosteroid-resistant asthma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26984691/cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma">cFLIP expression is altered in severe corticosteroid-resistant asthma</a></div><div class="wp-workCard_item"><span>Genomics Data</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984691"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984691"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984691; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984691]").text(description); $(".js-view-count[data-work-id=26984691]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984691; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984691']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984691, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26984691]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984691,"title":"cFLIP expression is altered in severe corticosteroid-resistant asthma","translated_title":"","metadata":{"abstract":"Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Genomics Data"},"translated_abstract":"Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.","internal_url":"https://www.academia.edu/26984691/cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma","translated_internal_url":"","created_at":"2016-07-14T08:17:36.333-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26984690"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26984690/Preliminary_Findings_from_the_New_York_City_Neighborhood_Asthma_and_Allergy_Study"><img alt="Research paper thumbnail of Preliminary Findings from the New York City Neighborhood Asthma and Allergy Study" class="work-thumbnail" src="https://attachments.academia-assets.com/47246539/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26984690/Preliminary_Findings_from_the_New_York_City_Neighborhood_Asthma_and_Allergy_Study">Preliminary Findings from the New York City Neighborhood Asthma and Allergy Study</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e10240d79b826d3921246808eaec454" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47246539,"asset_id":26984690,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47246539/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984690"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984690"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984690; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984690]").text(description); $(".js-view-count[data-work-id=26984690]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984690; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984690']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984690, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e10240d79b826d3921246808eaec454" } } $('.js-work-strip[data-work-id=26984690]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984690,"title":"Preliminary Findings from the New York City Neighborhood Asthma and Allergy Study","translated_title":"","metadata":{"grobid_abstract":"RATIONALE: Since traditional farming represents a unique model situation to investigate the relationship of early-life microbial exposure and allergy protection. associations between maternal farming exposures and cytokine production in cord blood mononuclear cells in a prospective multi-national birth cohort of 530 farm and 603 non-farm children and their families. METHODS: Supernatants from stimulated CB mononuclear cells were assessed for the production of IL-5, IFN-g, IL-10 IL-12 and TNF-a by using ELISA-assays. Associations between maternal farming exposures and the porduction of cord blood cytokines were assessed by using a Tobit-regression model. RESULTS: Cord blood from farmer children showed significantly higher levels of TNF-a and IFN-g production compared to cord blood non-farmer children, whereas IL-10, IL-12 and IL-5 levels did not differ between these study groups. Elevated TNF-a and IFN-g levels in cord blood were associated with maternal exposures to farm animals, animal sheds, hay lofts, farm milk and farm milk products during pregnancy. CONCLUSIONS: Maternal exposure to farming activities and farm products during pregnancy modulated cytokine production patterns of their offspring at birth.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Journal of Allergy and Clinical Immunology","grobid_abstract_attachment_id":47246539},"translated_abstract":null,"internal_url":"https://www.academia.edu/26984690/Preliminary_Findings_from_the_New_York_City_Neighborhood_Asthma_and_Allergy_Study","translated_internal_url":"","created_at":"2016-07-14T08:17:36.103-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":47246539,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246539/thumbnails/1.jpg","file_name":"j.jaci.2008.12.09320160714-27068-kl1ff6.pdf","download_url":"https://www.academia.edu/attachments/47246539/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Preliminary_Findings_from_the_New_York_C.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246539/j.jaci.2008.12.09320160714-27068-kl1ff6-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DPreliminary_Findings_from_the_New_York_C.pdf\u0026Expires=1732409848\u0026Signature=F6Wh2WklexdHb9ce0yG7yZRdlhGkix1-449yso1KLJ84NCffkDvzibbAOIu1Pul9aCpfbxsuGU6xFnyaM60jU8XSpz08nFmx0lVsN0zvShE7GCs2hzc6ac7mAxcRynuaPea4yDDx0mHx7jereZPgh1R0lAk6SzLhcZjCXkNziojBUU1PXund0yN8BCMSfKp~qccjLiZfboaQsV6IL6IAD16l1go5Vs3iEM~p2Aw~BSsIevCXek7S3Qw0vFLc2aZYVKZqRVOsCJHOSghngWIZVZXacblvJ6bvlQDoIad2A09jk0NYnfGcfhejvDo~tXv64OTZjEPSb~SM~qBWAIUXxg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Preliminary_Findings_from_the_New_York_City_Neighborhood_Asthma_and_Allergy_Study","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[{"id":47246539,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246539/thumbnails/1.jpg","file_name":"j.jaci.2008.12.09320160714-27068-kl1ff6.pdf","download_url":"https://www.academia.edu/attachments/47246539/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Preliminary_Findings_from_the_New_York_C.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246539/j.jaci.2008.12.09320160714-27068-kl1ff6-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DPreliminary_Findings_from_the_New_York_C.pdf\u0026Expires=1732409848\u0026Signature=F6Wh2WklexdHb9ce0yG7yZRdlhGkix1-449yso1KLJ84NCffkDvzibbAOIu1Pul9aCpfbxsuGU6xFnyaM60jU8XSpz08nFmx0lVsN0zvShE7GCs2hzc6ac7mAxcRynuaPea4yDDx0mHx7jereZPgh1R0lAk6SzLhcZjCXkNziojBUU1PXund0yN8BCMSfKp~qccjLiZfboaQsV6IL6IAD16l1go5Vs3iEM~p2Aw~BSsIevCXek7S3Qw0vFLc2aZYVKZqRVOsCJHOSghngWIZVZXacblvJ6bvlQDoIad2A09jk0NYnfGcfhejvDo~tXv64OTZjEPSb~SM~qBWAIUXxg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":87786,"name":"New York City","url":"https://www.academia.edu/Documents/in/New_York_City"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[]}, dispatcherData: dispatcherData }); 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Objective: Because the ALA-ACRC's recommendation would include vaccination of all patients with asthma, including those with severe asthma and first-time vaccinees, we conducted a parallel study to address whether patients with asthma who report bronchospasm after vaccination might be demonstrating a hypersensitivity response to the vaccine. Methods: Thirty-two adult patients with asthma from the ALA-ACRC cohort were recruited. Subjects were randomly assigned to receive influenza vaccine or placebo and then recorded asthma symptoms and peak expiratory flow rates for 14 days. On day 14, influenza vaccine and egg antigen-induced mononuclear cell proliferation and IFN-γ, IL-5, and IL-4 production were measured and compared with symptoms. Results: Increased influenza but not egg antigen-induced mononuclear cell proliferation was present among vaccinated subjects. These responses were unrelated to asthma exacerbations after vaccine. There were no differences in cytokine production in response to either influenza or egg antigen in association with asthma exacerbations. Conclusions: Episodes of bronchospasm after influenza vaccination do not seem related to hypersensitivity to the vaccine. (J Allergy Clin Immunol 2003;112:606-8.)","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Journal of Allergy and Clinical Immunology","grobid_abstract_attachment_id":47246537},"translated_abstract":null,"internal_url":"https://www.academia.edu/26984688/T_cell_responses_and_hypersensitivity_to_influenza_and_egg_antigens_among_adults_with_asthma_immunized_with_the_influenza_vaccine","translated_internal_url":"","created_at":"2016-07-14T08:17:35.633-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":47246537,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246537/thumbnails/1.jpg","file_name":"s0091-6749_2803_2901616-620160714-8748-o11oqj.pdf","download_url":"https://www.academia.edu/attachments/47246537/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"T_cell_responses_and_hypersensitivity_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246537/s0091-6749_2803_2901616-620160714-8748-o11oqj-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DT_cell_responses_and_hypersensitivity_to.pdf\u0026Expires=1732409848\u0026Signature=CcCEbX2WZblaB~ksXQWoGorxBHf34ZV7BE-iu3LfKzQYpSyXEz7Kjx~TRIqFR70iErpShbALhGrlsoeqMJxS7rah9AVhePy~Krg~AOQ1nrjWhlRjyUlcOwEXyreoGqSKE66y~wms6h1p4GCT30NQEKZke4waAzpRa~Uw2IgW0fe3R6owLZSBADSnU8iPWBLNqgGzrXr~XTxqwNfuhTpoFlob4XPVI-s94H~h4bLZjr7LNc4Ykm~ahfzl8PgICbS-Pz3ipVtZmGl4RDhpdF85~WwOxdDnlxP2dTwWSLbSXkuV40M0PYNacfTL2nsC-wYBWheENZR4ChEePRo7C83UiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"T_cell_responses_and_hypersensitivity_to_influenza_and_egg_antigens_among_adults_with_asthma_immunized_with_the_influenza_vaccine","translated_slug":"","page_count":3,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[{"id":47246537,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246537/thumbnails/1.jpg","file_name":"s0091-6749_2803_2901616-620160714-8748-o11oqj.pdf","download_url":"https://www.academia.edu/attachments/47246537/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"T_cell_responses_and_hypersensitivity_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246537/s0091-6749_2803_2901616-620160714-8748-o11oqj-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DT_cell_responses_and_hypersensitivity_to.pdf\u0026Expires=1732409848\u0026Signature=CcCEbX2WZblaB~ksXQWoGorxBHf34ZV7BE-iu3LfKzQYpSyXEz7Kjx~TRIqFR70iErpShbALhGrlsoeqMJxS7rah9AVhePy~Krg~AOQ1nrjWhlRjyUlcOwEXyreoGqSKE66y~wms6h1p4GCT30NQEKZke4waAzpRa~Uw2IgW0fe3R6owLZSBADSnU8iPWBLNqgGzrXr~XTxqwNfuhTpoFlob4XPVI-s94H~h4bLZjr7LNc4Ykm~ahfzl8PgICbS-Pz3ipVtZmGl4RDhpdF85~WwOxdDnlxP2dTwWSLbSXkuV40M0PYNacfTL2nsC-wYBWheENZR4ChEePRo7C83UiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":49161,"name":"Safety","url":"https://www.academia.edu/Documents/in/Safety"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes"},{"id":1274458,"name":"Antigens","url":"https://www.academia.edu/Documents/in/Antigens"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"urls":[]}, dispatcherData: dispatcherData }); 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RESULTS: Linear regression analysis showed a highly significant quantitative correlation between the multiplex array and ELISA for each of the allergens: R 2 values \u003e0.90, p\u003c0.001 for all allergens. The limits of detection of the multiplex array are an order of magnitude greater than ELISA, \u003c0.1 ng/mL, and interassay CVs are less than 20%. CONCLUSIONS: The simultaneous quantification of multiple allergens in a high throughput multiplex array has been developed. The array will be applicable to large population studies where the assessment of multiple allergens is required. The array will allow for greater efficiency, reproducibility and standardization in the measurement of indoor allergens.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Allergy and Clinical Immunology","grobid_abstract_attachment_id":47246540},"translated_abstract":null,"internal_url":"https://www.academia.edu/26984687/Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owners_Differs_Among_Ethnicities_But_Not_Neighborhood_In_Two_NYC_Cohorts","translated_internal_url":"","created_at":"2016-07-14T08:17:35.419-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":47246540,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246540/thumbnails/1.jpg","file_name":"j.jaci.2006.12.09320160714-21109-uo7k3l.pdf","download_url":"https://www.academia.edu/attachments/47246540/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246540/j.jaci.2006.12.09320160714-21109-uo7k3l-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DFel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf\u0026Expires=1732409848\u0026Signature=R9O9O2urkRfw4MWCSMKfrgsszACC3oeu4vg1FQ6-pKHsVJkhVcrlCCVSsuhDN8Vyv0s-SRAo6l7NavS05ZVxnGSOWCQngaUFKCG7WUmsQ7cmt~v4jdZZ9C7ThtzooTY3-L1GHsSevKBhhQPC4HQsF1i5Fij1XVGLS1PO6iGAUHTPVzAVaay0CXPWhdz~FkFjNGdL5Y8pfe-CZKuKnyLc3rK9Bwn7va78qU1m7DtpAiXqFieZLsZPW1mb7zs8ik9xer5TlLLIfvmdTlwXKYFgOjUthEV3ipLBi~BqdJq4fiNkc5f0s-b4vreqb97JCv3nHR53D5IqjGPapDPfwCY7IQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owners_Differs_Among_Ethnicities_But_Not_Neighborhood_In_Two_NYC_Cohorts","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[{"id":47246540,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246540/thumbnails/1.jpg","file_name":"j.jaci.2006.12.09320160714-21109-uo7k3l.pdf","download_url":"https://www.academia.edu/attachments/47246540/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246540/j.jaci.2006.12.09320160714-21109-uo7k3l-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DFel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf\u0026Expires=1732409848\u0026Signature=R9O9O2urkRfw4MWCSMKfrgsszACC3oeu4vg1FQ6-pKHsVJkhVcrlCCVSsuhDN8Vyv0s-SRAo6l7NavS05ZVxnGSOWCQngaUFKCG7WUmsQ7cmt~v4jdZZ9C7ThtzooTY3-L1GHsSevKBhhQPC4HQsF1i5Fij1XVGLS1PO6iGAUHTPVzAVaay0CXPWhdz~FkFjNGdL5Y8pfe-CZKuKnyLc3rK9Bwn7va78qU1m7DtpAiXqFieZLsZPW1mb7zs8ik9xer5TlLLIfvmdTlwXKYFgOjUthEV3ipLBi~BqdJq4fiNkc5f0s-b4vreqb97JCv3nHR53D5IqjGPapDPfwCY7IQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24555567"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24555567/Housing_Characteristics_and_Reported_Pest_Infestation_Differ_Among_Neighborhoods_with_High_and_Low_Asthma_Prevalence_in_New_York_City"><img alt="Research paper thumbnail of Housing Characteristics and Reported Pest Infestation Differ Among Neighborhoods with High and Low Asthma Prevalence in New York City" class="work-thumbnail" src="https://attachments.academia-assets.com/44885805/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24555567/Housing_Characteristics_and_Reported_Pest_Infestation_Differ_Among_Neighborhoods_with_High_and_Low_Asthma_Prevalence_in_New_York_City">Housing Characteristics and Reported Pest Infestation Differ Among Neighborhoods with High and Low Asthma Prevalence in New York City</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LHoepner">Lori Hoepner</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AndrewsHoward">Howard Andrews</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f5e11206419acd08ab58f8c7911eaeef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44885805,"asset_id":24555567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44885805/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24555567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24555567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24555567; 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Neighborhood-level differences in housing characteristics and pests may contribute to these disparities. METHODS: In our NYC Neighborhood Asthma and Allergy case-control study, 7-8 year-old children in low or high asthma prevalence neighborhoods (LAPN and HAPN) were recruited through parentsÕ employer-based health insurance. Comprehensive questionnaires were administered in the homes. Children were classified as probable asthmatics if they had wheezed, been awakened at night by cough, or taken asthma controller medication in the past year. RESULTS: To date questionnaires have been completed on 138 children, 68 from LAPN (33 asthmatics) and 70 from HAPN (47 asthmatics). Eighty percent of the children in the HAPN but only 28% in the LAPN lived in apartment buildings; the rest lived in single-family or multi-family detached houses. The number of people living in homes per bedroom was significantly higher among children in the HAPN than in the LAPN (2.2 vs. 1.9, p50.044). When compared with those in LAPN, more respondents in HAPN reported seeing cockroaches (34.3% vs. 17.6%, p50.026) and mice (21.4% vs. 7.4%, p50.019) at least once a week. Among asthmatic children, 57.4% in HAPN compared to 27.3% in LAPN were taken to the emergency department because of wheezing in the past year (p50.008). 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In this current paper, we di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Environmental contaminants pose a threat to infant neurodevelopment. In this current paper, we discuss evidence for the potentially harmful impact of fetal and early childhood exposure to polycyclic aromatic hydrocarbons (PAHs), environmental tobacco smoke (ETS), and organophosphorus (OP) insecticides. We focus on effects resulting from chronic and low-level exposure during the prenatal period and early childhood, when the brain is still undergoing rapid developmental changes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec8a2c238f5f5b4ac00f9c8f2e695add" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46026740,"asset_id":12652608,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46026740/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12652608"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12652608"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12652608; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12652608]").text(description); $(".js-view-count[data-work-id=12652608]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12652608; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12652608']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12652608, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ec8a2c238f5f5b4ac00f9c8f2e695add" } } $('.js-work-strip[data-work-id=12652608]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12652608,"title":"Neonatology and the Environment: Impact of Early Exposure to Airborne Environmental Toxicants on Infant and Child Neurodevelopment","translated_title":"","metadata":{"abstract":"Environmental contaminants pose a threat to infant neurodevelopment. 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behavior problems" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12652606/Early_life_exposure_to_polycyclic_aromatic_hydrocarbons_and_ADHD_behavior_problems">Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/VirginiaRauh">Virginia Rauh</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/EmilyRoen">Emily Roen</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RobertMaynard4">Robert Maynard</a></span></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fuel and other organic material shown previously to be neurotoxic. In a prospective cohort study, we evaluated the relationship between Attention Deficit Hyperactivity Disorder behavior problems and prenatal polycyclic aromatic hydrocarbon exposure, adjusting for postnatal exposure. Children of nonsmoking African-American and Dominican women in New York City were followed from in utero to 9 years. Prenatal polycyclic aromatic hydrocarbon exposure was estimated by levels of polycyclic aromatic hydrocarbon- DNA adducts in maternal and cord blood collected at delivery. Postnatal exposure was estimated by the concentration of urinary polycyclic aromatic hydrocarbon metabolites at ages 3 or 5. Attention Deficit Hyperactivity Disorder behavior problems were assessed using the Child Behavior Checklist and the Conners Parent Rating Scale- Revised. High prenatal adduct exposure, measured by elevate...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12652606"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12652606"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12652606; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12652606]").text(description); $(".js-view-count[data-work-id=12652606]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12652606; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12652606']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12652606, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12652606]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12652606,"title":"Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems","translated_title":"","metadata":{"abstract":"Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fuel and other organic material shown previously to be neurotoxic. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26145720"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26145720/T_helper_type_2_polarization_among_asthmatics_during_and_following_pregnancy"><img alt="Research paper thumbnail of T-helper type 2 polarization among asthmatics during and following pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/46478261/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26145720/T_helper_type_2_polarization_among_asthmatics_during_and_following_pregnancy">T-helper type 2 polarization among asthmatics during and following pregnancy</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RastogiDeepa">Deepa Rastogi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Clinical <html_ent glyph="@amp;" ascii="&amp;"/> Experimental Allergy</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc82cd548314c35349ca8a8ab5c53ac3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46478261,"asset_id":26145720,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46478261/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26145720"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26145720"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26145720; 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While increased production of T helper cytokines has been reported to occur in both asthma and pregnancy, the effect of T-helper type 2 (Th2) polarization on asthma symptoms during pregnancy has not been well-characterized. Objective We hypothesized that systemic Th2 cytokine and chemokine polarization occurs among asthmatics to a greater extent during their pregnancy, and is associated with more severe asthma and increased Th2 polarization in the newborn. Methods Fifty-six pregnant asthmatics were recruited from prenatal clinics affiliated with New York Presbyterian Hospital. Systemic production of interleukin-4, interferon-g, eotaxin and IP10 were measured by intracytoplasmic staining or ELISA at recruitment, peripartum and post-partum, and in the cord blood. The frequency of asthma symptoms was measured by questionnaires and compared with Th biomarkers. Results The chemokine ratio (IP10/eotaxin) declined over the course of pregnancy (from 3.3 AE 1.3 to 1.4 AE 0.2, P = 0.016), but IP10 and eotaxin increased post-partum. The decrease in the chemokine ratio was associated with more frequent asthma symptoms. A non-significant trend towards decreased interferon-g and increased interleukin-4 production was detected. Cord blood eotaxin levels correlated with maternal levels (r = 0.35, P = 0.03). Other peripartum biomarkers were not associated with Th2 polarization nor with subsequent respiratory symptoms in the newborn. Conclusions IP10/eotaxin declined over the course of pregnancy and was associated with worse asthma symptoms. Alterations of Th1/Th2 chemokine balance during pregnancy may identify women prone to more severe asthma during pregnancy.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Clinical \u003chtml_ent glyph=\"@amp;\" ascii=\"\u0026amp;\"/\u003e Experimental Allergy","grobid_abstract_attachment_id":46478261},"translated_abstract":null,"internal_url":"https://www.academia.edu/26145720/T_helper_type_2_polarization_among_asthmatics_during_and_following_pregnancy","translated_internal_url":"","created_at":"2016-06-14T08:01:02.210-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49867839,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":21299601,"work_id":26145720,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773777,"email":"m***n@uiowa.edu","display_order":0,"name":"Paul Rothman","title":"T-helper type 2 polarization among asthmatics during and following pregnancy"},{"id":21299608,"work_id":26145720,"tagging_user_id":49867839,"tagged_user_id":38212826,"co_author_invite_id":null,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia University","display_order":4194304,"name":"Rachel Miller","title":"T-helper type 2 polarization among asthmatics during and following pregnancy"},{"id":21299611,"work_id":26145720,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773778,"email":"c***r@mssm.edu","display_order":6291456,"name":"Cynthia Lendor","title":"T-helper type 2 polarization among asthmatics during and following 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26145731/B_cell_priming_in_utero_to_influenza_vaccination_1"><img alt="Research paper thumbnail of B cell priming in utero to influenza vaccination*1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26145731/B_cell_priming_in_utero_to_influenza_vaccination_1">B cell priming in utero to influenza vaccination*1</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RastogiDeepa">Deepa Rastogi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT RationaleInfluenza vaccination is recommended for women who are pregnant during the infl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT RationaleInfluenza vaccination is recommended for women who are pregnant during the influenza season. Nonetheless, the development of B cell priming to influenza antigens in utero is controversial. We hypothesized that neonatal B cells will exhibit antigen specific immune responses following influenza vaccination of the pregnant mother.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26145731"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26145731"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26145731; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26145731]").text(description); $(".js-view-count[data-work-id=26145731]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26145731; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26145731']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26145731, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26145731]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26145731,"title":"B cell priming in utero to influenza vaccination*1","translated_title":"","metadata":{"abstract":"ABSTRACT RationaleInfluenza vaccination is recommended for women who are pregnant during the influenza season. 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We hypothesized that neonatal B cells will exhibit antigen specific immune responses following influenza vaccination of the pregnant mother.","internal_url":"https://www.academia.edu/26145731/B_cell_priming_in_utero_to_influenza_vaccination_1","translated_internal_url":"","created_at":"2016-06-14T08:01:03.149-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49867839,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":21299575,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":1462740,"email":"y***a@cchmc.org","display_order":0,"name":"Y. Ogawa","title":"B cell priming in utero to influenza vaccination*1"},{"id":21299576,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773769,"email":"d***e@chase.com","display_order":4194304,"name":"D. Blythe","title":"B cell priming in utero to influenza vaccination*1"},{"id":21299609,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":38212826,"co_author_invite_id":null,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia University","display_order":6291456,"name":"Rachel Miller","title":"B cell priming in utero to influenza vaccination*1"},{"id":21299612,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773778,"email":"c***r@mssm.edu","display_order":7340032,"name":"Cynthia Lendor","title":"B cell priming in utero to influenza vaccination*1"}],"downloadable_attachments":[],"slug":"B_cell_priming_in_utero_to_influenza_vaccination_1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":49867839,"first_name":"Deepa","middle_initials":null,"last_name":"Rastogi","page_name":"RastogiDeepa","domain_name":"independent","created_at":"2016-06-09T14:15:31.570-07:00","display_name":"Deepa Rastogi","url":"https://independent.academia.edu/RastogiDeepa"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":57433,"name":"Seasonality","url":"https://www.academia.edu/Documents/in/Seasonality"},{"id":587989,"name":"Influenza Vaccine","url":"https://www.academia.edu/Documents/in/Influenza_Vaccine"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26145748"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26145748/Antigen_specific_immune_responses_to_influenza_vaccine_in_utero"><img alt="Research paper thumbnail of Antigen-specific immune responses to influenza vaccine in utero" class="work-thumbnail" src="https://attachments.academia-assets.com/46478259/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26145748/Antigen_specific_immune_responses_to_influenza_vaccine_in_utero">Antigen-specific immune responses to influenza vaccine in utero</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RastogiDeepa">Deepa Rastogi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Clinical Investigation</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="57b98e710bbd07869b42c09087d95c51" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46478259,"asset_id":26145748,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46478259/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26145748"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26145748"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26145748; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26145748]").text(description); $(".js-view-count[data-work-id=26145748]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26145748; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26145748']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26145748, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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This paradigm remains controversial, however, due to the inability to identify antigen-specific T cells in cord blood. The advent of MHC tetramers has revolutionized the detection of antigen-specific T cells. Tetramer staining of cord blood after CMV infection has demonstrated that effective CD8 + antigen-specific immune responses can follow intrauterine viral infections. We hypothesized that sensitization to antigens occurs in utero in humans. We studied cord blood B and T cell immune responses following vaccination against influenza during pregnancy. Anti-Fluzone and anti-matrix protein IgM antibodies were detected in 38.5% (27 of 70) and 40.0% (28 of 70), respectively, of cord blood specimens. Using MHC tetramers, HA-specific CD4 + T cells were detected among 25.0% (3 of 12) and 42.9% (6 of 14) of cord blood specimens possessing DRB1*0101 and DRB1*0401 HLA types, respectively, and were detected even when the DRB1 HLA type was inherited from the father. Matrix protein-specific CD8 + T cells were detected among 10.0% (2 of 20) of HLA-A*0201 + newborns. These results","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Clinical Investigation","grobid_abstract_attachment_id":46478259},"translated_abstract":null,"internal_url":"https://www.academia.edu/26145748/Antigen_specific_immune_responses_to_influenza_vaccine_in_utero","translated_internal_url":"","created_at":"2016-06-14T08:01:04.580-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49867839,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":21299602,"work_id":26145748,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773777,"email":"m***n@uiowa.edu","display_order":0,"name":"Paul Rothman","title":"Antigen-specific immune responses to influenza vaccine in utero"},{"id":21299610,"work_id":26145748,"tagging_user_id":49867839,"tagged_user_id":38212826,"co_author_invite_id":null,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia 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Rastogi","url":"https://independent.academia.edu/RastogiDeepa"},"attachments":[{"id":46478259,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/46478259/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/46478259/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antigen_specific_immune_responses_to_inf.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/46478259/pdf-libre.pdf?1465916773=\u0026response-content-disposition=attachment%3B+filename%3DAntigen_specific_immune_responses_to_inf.pdf\u0026Expires=1732409848\u0026Signature=DYRi0SQhLCWbDNAg8yW3gVCw6LRp3tzPqVF3e8mjKRalY-ADaueyALr6GMJQ0AKZ5si3QVz7ASVPKO1a0skIIQrYqP2EiT87oxyzkuJqpguZVoxR-vr2wA5dhq~myOLJTui~tQZCyxmIT8F2t1n88F9XjTHmmk-UOga1oOz5yg5cjTExfC0dOebTdcKgVjM0D2kS1Z2QKzKgTmmCJdLv6CW57MCypUiz01I85ILaumz20KeWg7k5Xi35f72YQzcHHbuzVxeZUaHZicSCdnQ-YtDoNeKw5w~k8RngIMDAhDkg-SFBW1~KyGuAcQwMtenVHQ0migH9fPt9Nt179ykZoQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":587989,"name":"Influenza Vaccine","url":"https://www.academia.edu/Documents/in/Influenza_Vaccine"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":1144154,"name":"Clinical Investigation","url":"https://www.academia.edu/Documents/in/Clinical_Investigation"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20038907"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20038907/Fractional_exhaled_nitric_oxide_exchange_parameters_among_9_year_old_inner_city_children"><img alt="Research paper thumbnail of Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children" class="work-thumbnail" src="https://attachments.academia-assets.com/41261893/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20038907/Fractional_exhaled_nitric_oxide_exchange_parameters_among_9_year_old_inner_city_children">Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/DiurkaDiaz">Diurka Diaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LHoepner">Lori Hoepner</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Pediatric Pulmonology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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new Works.PaperRankView({ workId: 20038907, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ad1ba748c556e98872e0e63995a91310" } } $('.js-work-strip[data-work-id=20038907]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20038907,"title":"Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children","translated_title":"","metadata":{"grobid_abstract":"Objectives and Hypothesis: To determine the feasibility of using a multiple flow offline fractional exhaled nitric oxide (FeNO) collection method in an inner-city cohort and determine this population's alveolar and conducting airway contributions of NO. We hypothesized that the flow independent NO parameters would be associated differentially with wheeze and seroatopy. Methods: As part of a birth cohort study, 9-year-old children (n ¼ 102) of African-American and Dominican mothers living in low-income NYC neighborhoods had FeNO samples collected offline at constant flow rates of 50, 83, and 100 ml/sec. Seroatopy was defined as having measurable (!0.35 IU/ml) specific IgE to any of the five inhalant indoor allergens tested. Current wheeze (last 12 months) was assessed by ISAAC questionnaire. Bronchial NO flux (J NO ) and alveolar NO concentration (C alv ) were estimated by the Pietropaoli and Hogman methods. Results: Valid exhalation flow rates were achieved in 96% of the children. Children with seroatopy (53%) had significantly higher median J NO (522 pl/sec vs. 161 pl/sec, P \u003c 0.001) when compared to nonseroatopic children; however, median C alv was not significantly different between these two groups (5.5 vs. 5.8, P ¼ 0.644). Children with wheeze in the past year (21.6%) had significantly higher median C alv (8.4 ppb vs. 4.9 ppb, P \u003c 0.001), but not J NO (295 pl/sec vs. 165 pl/sec, P ¼ 0.241) when compared with children without wheeze. These associations remained stable after adjustment for known confounders/covariates. Conclusions: The multiple flow method was easily implemented in this pediatric inner-city cohort. In this study population, alveolar concentration of NO may be a better indicator of current wheeze than single flow FeNO. Pediatr Pulmonol.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Pediatric Pulmonology","grobid_abstract_attachment_id":41261893},"translated_abstract":null,"internal_url":"https://www.academia.edu/20038907/Fractional_exhaled_nitric_oxide_exchange_parameters_among_9_year_old_inner_city_children","translated_internal_url":"","created_at":"2016-01-05T08:06:20.167-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":40977206,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":12589623,"work_id":20038907,"tagging_user_id":40977206,"tagged_user_id":null,"co_author_invite_id":2442935,"email":"f***1@pop-csm-vif.cc.columbia.edu","display_order":0,"name":"Frederica Perera","title":"Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city 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York City","url":"https://www.academia.edu/Documents/in/New_York_City"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":227842,"name":"Pediatric Pulmonology","url":"https://www.academia.edu/Documents/in/Pediatric_Pulmonology"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population"},{"id":1330083,"name":"Respiratory Sounds","url":"https://www.academia.edu/Documents/in/Respiratory_Sounds"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"},{"id":1840211,"name":"Pulmonary Gas Exchange","url":"https://www.academia.edu/Documents/in/Pulmonary_Gas_Exchange"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="18225355"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/18225355/Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_%CE%B1_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients"><img alt="Research paper thumbnail of Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/18225355/Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_%CE%B1_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients">Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients</a></div><div class="wp-workCard_item"><span>International immunopharmacology</span><span>, Jan 21, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driv...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated inflammation, TNF-α mediated asthma inflammation is generally insensitive to inhaled corticosteroids (ICS). ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. It also suppresses both Th2 and TNF-α associated inflammation in murine asthma models. We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation. Until now, there are limited studies on anti-TNF-α compounds presented in ASHMITM. The objective of this study was to isolate and identify TNF-α inhibitory compounds in ASHMITM. Here we report that G. lucidum, but not the other ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="18225355"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="18225355"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18225355; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18225355]").text(description); $(".js-view-count[data-work-id=18225355]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18225355; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='18225355']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 18225355, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=18225355]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":18225355,"title":"Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients","translated_title":"","metadata":{"abstract":"Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated inflammation, TNF-α mediated asthma inflammation is generally insensitive to inhaled corticosteroids (ICS). ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. It also suppresses both Th2 and TNF-α associated inflammation in murine asthma models. We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation. Until now, there are limited studies on anti-TNF-α compounds presented in ASHMITM. The objective of this study was to isolate and identify TNF-α inhibitory compounds in ASHMITM. Here we report that G. lucidum, but not the other ...","publication_date":{"day":21,"month":1,"year":2015,"errors":{}},"publication_name":"International immunopharmacology"},"translated_abstract":"Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated inflammation, TNF-α mediated asthma inflammation is generally insensitive to inhaled corticosteroids (ICS). ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. It also suppresses both Th2 and TNF-α associated inflammation in murine asthma models. We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation. Until now, there are limited studies on anti-TNF-α compounds presented in ASHMITM. The objective of this study was to isolate and identify TNF-α inhibitory compounds in ASHMITM. Here we report that G. lucidum, but not the other ...","internal_url":"https://www.academia.edu/18225355/Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_%CE%B1_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients","translated_internal_url":"","created_at":"2015-11-12T12:48:53.943-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":9593830,"work_id":18225355,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":2188960,"email":"d***n@mssm.edu","display_order":0,"name":"David Dunkin","title":"Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients"},{"id":9593862,"work_id":18225355,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":87534,"email":"x***i@mssm.edu","display_order":4194304,"name":"Xiu-min Li","title":"Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients"}],"downloadable_attachments":[],"slug":"Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_α_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[],"research_interests":[{"id":26699,"name":"Immunopharmacology","url":"https://www.academia.edu/Documents/in/Immunopharmacology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="18225354"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/18225354/Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ"><img alt="Research paper thumbnail of Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/18225354/Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ">Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ</a></div><div class="wp-workCard_item"><span>Neurotoxicology and Teratology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Tox...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed between groups of children whose mothers reported high vs. low material hardship during their pregnancy and through child age 5. We tested statistical interactions between hardships and polycyclic aromatic hydrocarbons, as measured by DNA adducts in cord blood, to determine whether material hardship exacerbated the association between adducts and IQ scores. Prospective cohort. Participants were recruited from 1998 to 2006 and followed from gestation through age 7years. Urban community (New York City) PARTICIPANTS: A community-based sample of 276 minority urban youth EXPOSURE MEASURE: Polycyclic aromatic hydrocarbon-DNA adducts in cord blood as an individual biomarker of prenatal polycyclic aromatic hydrocarbon exposure. Maternal material hardship self-reported prenatally and at multiple timepoints through early childhood. Child IQ at 7years assessed using the Wechsler Intelligence Scale for Children. Significant inverse effects of high cord PAH-DNA adducts on full scale IQ, perceptual reasoning and working memory scores were observed in the groups whose mothers reported a high level of material hardship during pregnancy or recurring high hardship into the child&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s early years, and not in those without reported high hardship. Significant interactions were observed between high cord adducts and prenatal hardship on working memory scores (β=-8.07, 95% CI (-14.48, -1.66)) and between high cord adducts and recurrent material hardship (β=-9.82, 95% CI (-16.22, -3.42)). The findings add to other evidence that socioeconomic disadvantage can increase the adverse effects of toxic physical &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;stressors&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; like air pollutants. Observed associations between high cord adducts and reduced IQ were significant only among the group of children whose mothers reported high material hardship. These results indicate the need for a multifaceted approach to prevention.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="18225354"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="18225354"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18225354; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18225354]").text(description); $(".js-view-count[data-work-id=18225354]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18225354; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='18225354']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 18225354, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=18225354]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":18225354,"title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ","translated_title":"","metadata":{"abstract":"Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed between groups of children whose mothers reported high vs. low material hardship during their pregnancy and through child age 5. We tested statistical interactions between hardships and polycyclic aromatic hydrocarbons, as measured by DNA adducts in cord blood, to determine whether material hardship exacerbated the association between adducts and IQ scores. Prospective cohort. Participants were recruited from 1998 to 2006 and followed from gestation through age 7years. Urban community (New York City) PARTICIPANTS: A community-based sample of 276 minority urban youth EXPOSURE MEASURE: Polycyclic aromatic hydrocarbon-DNA adducts in cord blood as an individual biomarker of prenatal polycyclic aromatic hydrocarbon exposure. Maternal material hardship self-reported prenatally and at multiple timepoints through early childhood. Child IQ at 7years assessed using the Wechsler Intelligence Scale for Children. Significant inverse effects of high cord PAH-DNA adducts on full scale IQ, perceptual reasoning and working memory scores were observed in the groups whose mothers reported a high level of material hardship during pregnancy or recurring high hardship into the child\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s early years, and not in those without reported high hardship. Significant interactions were observed between high cord adducts and prenatal hardship on working memory scores (β=-8.07, 95% CI (-14.48, -1.66)) and between high cord adducts and recurrent material hardship (β=-9.82, 95% CI (-16.22, -3.42)). The findings add to other evidence that socioeconomic disadvantage can increase the adverse effects of toxic physical \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;stressors\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; like air pollutants. Observed associations between high cord adducts and reduced IQ were significant only among the group of children whose mothers reported high material hardship. These results indicate the need for a multifaceted approach to prevention.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Neurotoxicology and Teratology"},"translated_abstract":"Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed between groups of children whose mothers reported high vs. low material hardship during their pregnancy and through child age 5. We tested statistical interactions between hardships and polycyclic aromatic hydrocarbons, as measured by DNA adducts in cord blood, to determine whether material hardship exacerbated the association between adducts and IQ scores. Prospective cohort. Participants were recruited from 1998 to 2006 and followed from gestation through age 7years. Urban community (New York City) PARTICIPANTS: A community-based sample of 276 minority urban youth EXPOSURE MEASURE: Polycyclic aromatic hydrocarbon-DNA adducts in cord blood as an individual biomarker of prenatal polycyclic aromatic hydrocarbon exposure. Maternal material hardship self-reported prenatally and at multiple timepoints through early childhood. Child IQ at 7years assessed using the Wechsler Intelligence Scale for Children. Significant inverse effects of high cord PAH-DNA adducts on full scale IQ, perceptual reasoning and working memory scores were observed in the groups whose mothers reported a high level of material hardship during pregnancy or recurring high hardship into the child\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s early years, and not in those without reported high hardship. Significant interactions were observed between high cord adducts and prenatal hardship on working memory scores (β=-8.07, 95% CI (-14.48, -1.66)) and between high cord adducts and recurrent material hardship (β=-9.82, 95% CI (-16.22, -3.42)). The findings add to other evidence that socioeconomic disadvantage can increase the adverse effects of toxic physical \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;stressors\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; like air pollutants. Observed associations between high cord adducts and reduced IQ were significant only among the group of children whose mothers reported high material hardship. These results indicate the need for a multifaceted approach to prevention.","internal_url":"https://www.academia.edu/18225354/Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ","translated_internal_url":"","created_at":"2015-11-12T12:48:53.767-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":9593737,"work_id":18225354,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":128915,"email":"f***1@columbia.cdu","display_order":0,"name":"Frederica Perera","title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ"},{"id":9593832,"work_id":18225354,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":424339,"email":"s***g@columbia.edu","display_order":4194304,"name":"Shuang Wang","title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ"},{"id":9593834,"work_id":18225354,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":424351,"email":"j***8@columbia.edu","display_order":6291456,"name":"Julie Herbstman","title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ"}],"downloadable_attachments":[],"slug":"Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14182763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14182763/Effects_of_Prenatal_Exposure_to_Air_Pollutants_Polycyclic_Aromatic_Hydrocarbons_on_the_Development_of_Brain_White_Matter_Cognition_and_Behavior_in_Later_Childhood"><img alt="Research paper thumbnail of Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14182763/Effects_of_Prenatal_Exposure_to_Air_Pollutants_Polycyclic_Aromatic_Hydrocarbons_on_the_Development_of_Brain_White_Matter_Cognition_and_Behavior_in_Later_Childhood">Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://mercy.academia.edu/KirwanWalsh">Kirwan Walsh</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/VirginiaRauh">Virginia Rauh</a></span></div><div class="wp-workCard_item"><span>JAMA Psychiatry</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood. To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those abnormalities in school-age children. Cross-sectional imaging study in a representative community-based cohort followed up prospectively from the fetal period to ages 7 to 9 years. The setting was urban community residences and an academic imaging center. Participants included a sample of 40 minority urban youth born to Latina (Dominican) or African American women. They were recruited between February 2, 1998, and March 17, 2006. Morphological measures that index local volumes of the surface of the brain and of the white matter surface after cortical gray matter was removed. We detected a dose-response relationship between increased prenatal PAH exposure (measured in the third trimester but thought to index exposure for all of gestation) and reductions of the white matter surface in later childhood that were confined almost exclusively to the left hemisphere of the brain and that involved almost its entire surface. Reduced left hemisphere white matter was associated with slower information processing speed during intelligence testing and with more severe externalizing behavioral problems, including attention-deficit/hyperactivity disorder symptoms and conduct disorder problems. The magnitude of left hemisphere white matter disturbances mediated the significant association of PAH exposure with slower processing speed. In addition, measures of postnatal PAH exposure correlated with white matter surface measures in dorsal prefrontal regions bilaterally when controlling for prenatal PAH. Our findings suggest that prenatal exposure to PAH air pollutants contributes to slower processing speed, attention-deficit/hyperactivity disorder symptoms, and externalizing problems in urban youth by disrupting the development of left hemisphere white matter, whereas postnatal PAH exposure contributes to additional disturbances in the development of white matter in dorsal prefrontal regions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14182763"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14182763"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14182763; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14182763]").text(description); $(".js-view-count[data-work-id=14182763]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14182763; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14182763']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14182763, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14182763]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14182763,"title":"Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood","translated_title":"","metadata":{"abstract":"Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood. To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those abnormalities in school-age children. Cross-sectional imaging study in a representative community-based cohort followed up prospectively from the fetal period to ages 7 to 9 years. The setting was urban community residences and an academic imaging center. Participants included a sample of 40 minority urban youth born to Latina (Dominican) or African American women. They were recruited between February 2, 1998, and March 17, 2006. Morphological measures that index local volumes of the surface of the brain and of the white matter surface after cortical gray matter was removed. We detected a dose-response relationship between increased prenatal PAH exposure (measured in the third trimester but thought to index exposure for all of gestation) and reductions of the white matter surface in later childhood that were confined almost exclusively to the left hemisphere of the brain and that involved almost its entire surface. Reduced left hemisphere white matter was associated with slower information processing speed during intelligence testing and with more severe externalizing behavioral problems, including attention-deficit/hyperactivity disorder symptoms and conduct disorder problems. The magnitude of left hemisphere white matter disturbances mediated the significant association of PAH exposure with slower processing speed. In addition, measures of postnatal PAH exposure correlated with white matter surface measures in dorsal prefrontal regions bilaterally when controlling for prenatal PAH. Our findings suggest that prenatal exposure to PAH air pollutants contributes to slower processing speed, attention-deficit/hyperactivity disorder symptoms, and externalizing problems in urban youth by disrupting the development of left hemisphere white matter, whereas postnatal PAH exposure contributes to additional disturbances in the development of white matter in dorsal prefrontal regions.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"JAMA Psychiatry"},"translated_abstract":"Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood. To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those abnormalities in school-age children. Cross-sectional imaging study in a representative community-based cohort followed up prospectively from the fetal period to ages 7 to 9 years. The setting was urban community residences and an academic imaging center. Participants included a sample of 40 minority urban youth born to Latina (Dominican) or African American women. They were recruited between February 2, 1998, and March 17, 2006. Morphological measures that index local volumes of the surface of the brain and of the white matter surface after cortical gray matter was removed. We detected a dose-response relationship between increased prenatal PAH exposure (measured in the third trimester but thought to index exposure for all of gestation) and reductions of the white matter surface in later childhood that were confined almost exclusively to the left hemisphere of the brain and that involved almost its entire surface. Reduced left hemisphere white matter was associated with slower information processing speed during intelligence testing and with more severe externalizing behavioral problems, including attention-deficit/hyperactivity disorder symptoms and conduct disorder problems. The magnitude of left hemisphere white matter disturbances mediated the significant association of PAH exposure with slower processing speed. In addition, measures of postnatal PAH exposure correlated with white matter surface measures in dorsal prefrontal regions bilaterally when controlling for prenatal PAH. Our findings suggest that prenatal exposure to PAH air pollutants contributes to slower processing speed, attention-deficit/hyperactivity disorder symptoms, and externalizing problems in urban youth by disrupting the development of left hemisphere white matter, whereas postnatal PAH exposure contributes to additional disturbances in the development of white matter in dorsal prefrontal regions.","internal_url":"https://www.academia.edu/14182763/Effects_of_Prenatal_Exposure_to_Air_Pollutants_Polycyclic_Aromatic_Hydrocarbons_on_the_Development_of_Brain_White_Matter_Cognition_and_Behavior_in_Later_Childhood","translated_internal_url":"","created_at":"2015-07-18T20:15:02.649-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33166329,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":3421383,"work_id":14182763,"tagging_user_id":33166329,"tagged_user_id":38212826,"co_author_invite_id":412844,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia University","display_order":0,"name":"Rachel Miller","title":"Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later 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Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood"},{"id":22392401,"work_id":14182763,"tagging_user_id":31638725,"tagged_user_id":null,"co_author_invite_id":3495353,"email":"g***0@tc.columbia.edu","display_order":8372224,"name":"Giancarlo Nati","title":"Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood"},{"id":22392402,"work_id":14182763,"tagging_user_id":31638725,"tagged_user_id":null,"co_author_invite_id":4998892,"email":"s***d@childpsych.columbia.edu","display_order":8380416,"name":"David Semanek","title":"Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later 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class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27537966/Effects_of_Ambient_Nickel_Vanadium_and_Zinc_on_Wheeze_and_Cough_in_Early_Childhood"><img alt="Research paper thumbnail of Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early Childhood" class="work-thumbnail" src="https://attachments.academia-assets.com/47791694/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27537966/Effects_of_Ambient_Nickel_Vanadium_and_Zinc_on_Wheeze_and_Cough_in_Early_Childhood">Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early Childhood</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RobinGarfinkel">Robin Garfinkel</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/StevenChillrud">Steven Chillrud</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="522e0549527328af509efbef93bf7d45" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47791694,"asset_id":27537966,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47791694/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa 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});</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27537966; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27537966']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27537966, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "522e0549527328af509efbef93bf7d45" } } $('.js-work-strip[data-work-id=27537966]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27537966,"title":"Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early Childhood","translated_title":"","metadata":{"grobid_abstract":"RATIONALE: ETS is known to be an important aggravating factor in asthma. Children is commonly exposed to passive smoking. We determined whether ETS have influence on the sputum concentration of VEGF in asthmatic children. METHODS:75 asthmatic children were enrolled, who were hospitalized with asthma symptom in Geoje Baek Hospital. We measured the urinary cotinine concentrations of asthma children patient for assessment of passive smoking. 75 asthmatic children were classified as ETS group(n 5 32) and non-ETS group(n 5 43). We measured VEGF levels in induced sputum from asthmatic children patient. We compared the sputum VEGF levels of 2 groups. RESULTS: Asthmatic children of ETS group showed higher sputum VEGF levels than those of non-ETS group (683.1 6 62.3 ng/mL vs. 241.6 6 38.4 ng/mL) (p 5 0.004). CONCLUSIONS: When asthmatic children were exposed to familial passive smoking, the higher levels of VEGF were measured in their sputum. We may suggest the possibility of improving illness by reducing exposure to ETS. RATIONALE: Despite well-documented associations between traffic-related pollutants such as PM2.5 and NOx and asthma outcomes, effects of trace elements have not been fully characterized. Our objectives were to examine temporal associations between airborne levels of individual metals, including nickel, vanadium, and zinc, and longitudinal reports of respiratory symptoms in children through age 24 months. METHODS: The study population included participants from the Columbia Center for Children's Environmental Health birth cohort. Data on presence and number of days of wheeze or cough were collected by questionnaire every 3 months, between 3 and 24 months of age. Ambient metals concentrations were obtained for monitoring sites operated by the New York State Department of Environmental Conservation and located within the study area. For each subject, 3-month average concentrations of nickel, vanadium, and zinc were calculated for each symptom reporting period based on the questionnaire date and the preceding 3 months. Associations between metals and symptoms were characterized using mixed models, adjusting for sex, ethnicity, environmental tobacco smoke exposure, and cold/flu season. RESULTS: Increases in ambient concentrations of nickel, vanadium, and zinc were significantly associated with increased probability of wheeze and cough. Increases in metals also were significantly associated with increases in the number of days of symptoms, possibly indicating greater severity of symptoms resulting from higher metals exposures. CONCLUSIONS: These results suggest that increases in ambient concentrations of traffic-related metals may be associated with increased probability of respiratory symptoms in young, inner city children. The findings highlight the need for measurement of specific traffic-related air pollution components. RATIONALE: Stachybotrys chartarum is a mold associated with waterdamaged buildings that can produce mycotoxins. Reliable methods for assessment of exposure to molds are critical to determine risks associated with mold exposure. Our aim was to develop sensitive immunoassays using ELISA and fluorescent multiplex array technology for the detection of S. chartarum antigen. METHODS: Extracts of 13 isolates of S. chartarum as well as of 10 other mold species commonly found in water-damaged buildings were screened using ELISA for Sch34 antigen (see JIM 332: 2008). These extracts were also tested by fluorescent multiplex array using monoclonal antibodies covalently coupled to internally labeled microspheres. A panel of 5 newly developed monoclonal anti-S. chartarum antibodies was tested against mold extracts to determine species-specificity. RESULTS: The ELISA and multiplex array for Sch34 antigen did not cross-react with the 10 mold species tested and were shown to be specific for S. chartarum and S. chlorohalonata. Both assays exhibited high levels of sensitivity: Dynamic ranges were 6-0.38ng/ml for ELISA and 6-0.01ng/ ml for the fluorescent multiplex array. Results between ELISA and multiplex array were closely correlated (r 5 0.99, n 5 16). The 5 newly developed monoclonal antibodies were also found to be species-specific for S. chartarum. CONCLUSIONS: We have developed species-specific and highly sensitive assays for S. chartarum antigen using monoclonal antibody-based ELISA and fluorescent multiplex array. The data suggest that murine antibody responses to S. chartarum tend to be species specific and/or that S. chartarum produces unique antigens. RATIONALE: The effects of air conditioner filter on the removal of airborne indoor allergens, especially house dust mite, are still controversial. We evaluated the effect of fine mechanical filter air cleaner (model: S12AA;","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Journal of Allergy and Clinical Immunology","grobid_abstract_attachment_id":47791694},"translated_abstract":null,"internal_url":"https://www.academia.edu/27537966/Effects_of_Ambient_Nickel_Vanadium_and_Zinc_on_Wheeze_and_Cough_in_Early_Childhood","translated_internal_url":"","created_at":"2016-08-04T10:03:26.024-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51657540,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":23108851,"work_id":27537966,"tagging_user_id":51657540,"tagged_user_id":null,"co_author_invite_id":793038,"email":"m***p@umich.edu","display_order":0,"name":"Minal Patel","title":"Effects of Ambient Nickel, Vanadium, and Zinc on Wheeze and Cough in Early 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Allergen Levels And Fractional Exhaled Nitric Oxide At Age 5-11 Years" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/20038908/Association_Between_Prenatal_Home_Cockroach_Allergen_Levels_And_Fractional_Exhaled_Nitric_Oxide_At_Age_5_11_Years">Association Between Prenatal Home Cockroach Allergen Levels And Fractional Exhaled Nitric Oxide At Age 5-11 Years</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/DiurkaDiaz">Diurka Diaz</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div 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OUTCOME MEASURES TO ASSESS PEDIATRIC LUNG HEALTH</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="20038908"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="20038908"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 20038908; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=20038908]").text(description); $(".js-view-count[data-work-id=20038908]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 20038908; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='20038908']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20038908, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=20038908]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20038908,"title":"Association Between Prenatal Home Cockroach Allergen Levels And Fractional Exhaled Nitric Oxide At Age 5-11 Years","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"B107. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26984693"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26984693/The_Impact_of_Bisphenol_A_and_Phthalates_on_Allergy_Asthma_and_Immune_Function_a_Review_of_Latest_Findings"><img alt="Research paper thumbnail of The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26984693/The_Impact_of_Bisphenol_A_and_Phthalates_on_Allergy_Asthma_and_Immune_Function_a_Review_of_Latest_Findings">The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings</a></div><div class="wp-workCard_item"><span>Current environmental health reports</span><span>, Jan 4, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In recent years, the impact of environmental exposure to chemicals and their immunological effect...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine-disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, is ubiquitous. The links between their exposure and the development of allergy, asthma, and immune dysfunction have been studied in vitro, in vivo, and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy, and asthma after dietary and inhalation exposure to these chemicals, may be occurring.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984693"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984693"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984693; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984693]").text(description); $(".js-view-count[data-work-id=26984693]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984693; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984693']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984693, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26984693]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984693,"title":"The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings","translated_title":"","metadata":{"abstract":"In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. 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However, data regarding the incidence and prevalence of anaphylaxis and the number of deaths caused by it are limited. To provide a better understanding of the magnitude of the problem of anaphylaxis in the United States. A thorough review of the current medical literature was conducted to obtain prevalence estimates on each of the 4 major subtypes of anaphylaxis (food, drugs, latex, and insect stings). We calculated an overall estimate of the risk of anaphylaxis by using only estimates that are specifically derived from epidemiologic studies measuring anaphylaxis in the general population. Known rates or cases of anaphylaxis were 0.0004% for food, 0.7% to 10% for penicillin, 0. 22% to 1% for radiocontrast media, and 0.5% to 5% after insect stings. There were 220 cases after latex exposure. Considering the 1999 US population of 272 million, the population at risk f...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a784ce220029b9f1081d437d771a4599" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47246538,"asset_id":26984692,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47246538/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984692"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984692"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984692; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984692]").text(description); $(".js-view-count[data-work-id=26984692]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984692; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984692']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984692, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a784ce220029b9f1081d437d771a4599" } } $('.js-work-strip[data-work-id=26984692]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984692,"title":"Anaphylaxis in the United States: an investigation into its epidemiology","translated_title":"","metadata":{"abstract":"Anaphylaxis is a severe, life-threatening allergic reaction that affects both children and adults in the United States. 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Known rates or cases of anaphylaxis were 0.0004% for food, 0.7% to 10% for penicillin, 0. 22% to 1% for radiocontrast media, and 0.5% to 5% after insect stings. There were 220 cases after latex exposure. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26984691"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26984691/cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma"><img alt="Research paper thumbnail of cFLIP expression is altered in severe corticosteroid-resistant asthma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26984691/cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma">cFLIP expression is altered in severe corticosteroid-resistant asthma</a></div><div class="wp-workCard_item"><span>Genomics Data</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984691"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984691"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984691; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984691]").text(description); $(".js-view-count[data-work-id=26984691]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984691; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984691']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984691, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26984691]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984691,"title":"cFLIP expression is altered in severe corticosteroid-resistant asthma","translated_title":"","metadata":{"abstract":"Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Genomics Data"},"translated_abstract":"Dysregulation of alternative splicing of mRNA precursors is known to contribute to numerous human diseases. In this study we carried out the first systematic search for asthma-associated changes in alternative splicing events, using a model of Aspergillus fumigatus (A. fumigatus)-sensitized mice and an exon junction microarray to detect potential changes in alternative splicing. One of the sensitization-associated changes identified in the search was a shift in alternative splicing of the mRNA encoding cFLIP, a modulator of the caspase-mediated extrinsic apoptosis pathway. Expanding these studies to human asthma patients, we discovered a significant decrease in the expression of both cFLIP isoforms in severe corticosteroid-resistant asthmatics. Although it is unclear whether these changes were due solely to differences in alternative splicing, these findings provide evidence that dysregulation of the extrinsic apoptosis pathway is part of the underlying immunopathogenesis of severe refractory asthma.","internal_url":"https://www.academia.edu/26984691/cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma","translated_internal_url":"","created_at":"2016-07-14T08:17:36.333-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"cFLIP_expression_is_altered_in_severe_corticosteroid_resistant_asthma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26984690"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26984690/Preliminary_Findings_from_the_New_York_City_Neighborhood_Asthma_and_Allergy_Study"><img alt="Research paper thumbnail of Preliminary Findings from the New York City Neighborhood Asthma and Allergy Study" class="work-thumbnail" src="https://attachments.academia-assets.com/47246539/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26984690/Preliminary_Findings_from_the_New_York_City_Neighborhood_Asthma_and_Allergy_Study">Preliminary Findings from the New York City Neighborhood Asthma and Allergy Study</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e10240d79b826d3921246808eaec454" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47246539,"asset_id":26984690,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47246539/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26984690"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26984690"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26984690; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26984690]").text(description); $(".js-view-count[data-work-id=26984690]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26984690; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26984690']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26984690, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e10240d79b826d3921246808eaec454" } } $('.js-work-strip[data-work-id=26984690]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26984690,"title":"Preliminary Findings from the New York City Neighborhood Asthma and Allergy Study","translated_title":"","metadata":{"grobid_abstract":"RATIONALE: Since traditional farming represents a unique model situation to investigate the relationship of early-life microbial exposure and allergy protection. associations between maternal farming exposures and cytokine production in cord blood mononuclear cells in a prospective multi-national birth cohort of 530 farm and 603 non-farm children and their families. METHODS: Supernatants from stimulated CB mononuclear cells were assessed for the production of IL-5, IFN-g, IL-10 IL-12 and TNF-a by using ELISA-assays. Associations between maternal farming exposures and the porduction of cord blood cytokines were assessed by using a Tobit-regression model. RESULTS: Cord blood from farmer children showed significantly higher levels of TNF-a and IFN-g production compared to cord blood non-farmer children, whereas IL-10, IL-12 and IL-5 levels did not differ between these study groups. Elevated TNF-a and IFN-g levels in cord blood were associated with maternal exposures to farm animals, animal sheds, hay lofts, farm milk and farm milk products during pregnancy. 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Objective: Because the ALA-ACRC's recommendation would include vaccination of all patients with asthma, including those with severe asthma and first-time vaccinees, we conducted a parallel study to address whether patients with asthma who report bronchospasm after vaccination might be demonstrating a hypersensitivity response to the vaccine. Methods: Thirty-two adult patients with asthma from the ALA-ACRC cohort were recruited. Subjects were randomly assigned to receive influenza vaccine or placebo and then recorded asthma symptoms and peak expiratory flow rates for 14 days. On day 14, influenza vaccine and egg antigen-induced mononuclear cell proliferation and IFN-γ, IL-5, and IL-4 production were measured and compared with symptoms. Results: Increased influenza but not egg antigen-induced mononuclear cell proliferation was present among vaccinated subjects. These responses were unrelated to asthma exacerbations after vaccine. There were no differences in cytokine production in response to either influenza or egg antigen in association with asthma exacerbations. Conclusions: Episodes of bronchospasm after influenza vaccination do not seem related to hypersensitivity to the vaccine. 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RESULTS: Linear regression analysis showed a highly significant quantitative correlation between the multiplex array and ELISA for each of the allergens: R 2 values \u003e0.90, p\u003c0.001 for all allergens. The limits of detection of the multiplex array are an order of magnitude greater than ELISA, \u003c0.1 ng/mL, and interassay CVs are less than 20%. CONCLUSIONS: The simultaneous quantification of multiple allergens in a high throughput multiplex array has been developed. The array will be applicable to large population studies where the assessment of multiple allergens is required. The array will allow for greater efficiency, reproducibility and standardization in the measurement of indoor allergens.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Allergy and Clinical Immunology","grobid_abstract_attachment_id":47246540},"translated_abstract":null,"internal_url":"https://www.academia.edu/26984687/Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owners_Differs_Among_Ethnicities_But_Not_Neighborhood_In_Two_NYC_Cohorts","translated_internal_url":"","created_at":"2016-07-14T08:17:35.419-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":47246540,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246540/thumbnails/1.jpg","file_name":"j.jaci.2006.12.09320160714-21109-uo7k3l.pdf","download_url":"https://www.academia.edu/attachments/47246540/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246540/j.jaci.2006.12.09320160714-21109-uo7k3l-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DFel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf\u0026Expires=1732409848\u0026Signature=R9O9O2urkRfw4MWCSMKfrgsszACC3oeu4vg1FQ6-pKHsVJkhVcrlCCVSsuhDN8Vyv0s-SRAo6l7NavS05ZVxnGSOWCQngaUFKCG7WUmsQ7cmt~v4jdZZ9C7ThtzooTY3-L1GHsSevKBhhQPC4HQsF1i5Fij1XVGLS1PO6iGAUHTPVzAVaay0CXPWhdz~FkFjNGdL5Y8pfe-CZKuKnyLc3rK9Bwn7va78qU1m7DtpAiXqFieZLsZPW1mb7zs8ik9xer5TlLLIfvmdTlwXKYFgOjUthEV3ipLBi~BqdJq4fiNkc5f0s-b4vreqb97JCv3nHR53D5IqjGPapDPfwCY7IQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owners_Differs_Among_Ethnicities_But_Not_Neighborhood_In_Two_NYC_Cohorts","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[{"id":47246540,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47246540/thumbnails/1.jpg","file_name":"j.jaci.2006.12.09320160714-21109-uo7k3l.pdf","download_url":"https://www.academia.edu/attachments/47246540/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Fel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47246540/j.jaci.2006.12.09320160714-21109-uo7k3l-libre.pdf?1468510095=\u0026response-content-disposition=attachment%3B+filename%3DFel_d_1_In_The_Bed_Dust_Of_Cat_Non_Owner.pdf\u0026Expires=1732409848\u0026Signature=R9O9O2urkRfw4MWCSMKfrgsszACC3oeu4vg1FQ6-pKHsVJkhVcrlCCVSsuhDN8Vyv0s-SRAo6l7NavS05ZVxnGSOWCQngaUFKCG7WUmsQ7cmt~v4jdZZ9C7ThtzooTY3-L1GHsSevKBhhQPC4HQsF1i5Fij1XVGLS1PO6iGAUHTPVzAVaay0CXPWhdz~FkFjNGdL5Y8pfe-CZKuKnyLc3rK9Bwn7va78qU1m7DtpAiXqFieZLsZPW1mb7zs8ik9xer5TlLLIfvmdTlwXKYFgOjUthEV3ipLBi~BqdJq4fiNkc5f0s-b4vreqb97JCv3nHR53D5IqjGPapDPfwCY7IQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24555567"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24555567/Housing_Characteristics_and_Reported_Pest_Infestation_Differ_Among_Neighborhoods_with_High_and_Low_Asthma_Prevalence_in_New_York_City"><img alt="Research paper thumbnail of Housing Characteristics and Reported Pest Infestation Differ Among Neighborhoods with High and Low Asthma Prevalence in New York City" class="work-thumbnail" src="https://attachments.academia-assets.com/44885805/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24555567/Housing_Characteristics_and_Reported_Pest_Infestation_Differ_Among_Neighborhoods_with_High_and_Low_Asthma_Prevalence_in_New_York_City">Housing Characteristics and Reported Pest Infestation Differ Among Neighborhoods with High and Low Asthma Prevalence in New York City</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LHoepner">Lori Hoepner</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AndrewsHoward">Howard Andrews</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f5e11206419acd08ab58f8c7911eaeef" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":44885805,"asset_id":24555567,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/44885805/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24555567"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24555567"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24555567; 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Neighborhood-level differences in housing characteristics and pests may contribute to these disparities. METHODS: In our NYC Neighborhood Asthma and Allergy case-control study, 7-8 year-old children in low or high asthma prevalence neighborhoods (LAPN and HAPN) were recruited through parentsÕ employer-based health insurance. Comprehensive questionnaires were administered in the homes. Children were classified as probable asthmatics if they had wheezed, been awakened at night by cough, or taken asthma controller medication in the past year. RESULTS: To date questionnaires have been completed on 138 children, 68 from LAPN (33 asthmatics) and 70 from HAPN (47 asthmatics). Eighty percent of the children in the HAPN but only 28% in the LAPN lived in apartment buildings; the rest lived in single-family or multi-family detached houses. The number of people living in homes per bedroom was significantly higher among children in the HAPN than in the LAPN (2.2 vs. 1.9, p50.044). When compared with those in LAPN, more respondents in HAPN reported seeing cockroaches (34.3% vs. 17.6%, p50.026) and mice (21.4% vs. 7.4%, p50.019) at least once a week. Among asthmatic children, 57.4% in HAPN compared to 27.3% in LAPN were taken to the emergency department because of wheezing in the past year (p50.008). 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In this current paper, we di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Environmental contaminants pose a threat to infant neurodevelopment. In this current paper, we discuss evidence for the potentially harmful impact of fetal and early childhood exposure to polycyclic aromatic hydrocarbons (PAHs), environmental tobacco smoke (ETS), and organophosphorus (OP) insecticides. 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behavior problems" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12652606/Early_life_exposure_to_polycyclic_aromatic_hydrocarbons_and_ADHD_behavior_problems">Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/VirginiaRauh">Virginia Rauh</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/EmilyRoen">Emily Roen</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RobertMaynard4">Robert Maynard</a></span></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycyclic aromatic hydrocarbons are widespread urban air pollutants from combustion of fossil fuel and other organic material shown previously to be neurotoxic. In a prospective cohort study, we evaluated the relationship between Attention Deficit Hyperactivity Disorder behavior problems and prenatal polycyclic aromatic hydrocarbon exposure, adjusting for postnatal exposure. Children of nonsmoking African-American and Dominican women in New York City were followed from in utero to 9 years. Prenatal polycyclic aromatic hydrocarbon exposure was estimated by levels of polycyclic aromatic hydrocarbon- DNA adducts in maternal and cord blood collected at delivery. Postnatal exposure was estimated by the concentration of urinary polycyclic aromatic hydrocarbon metabolites at ages 3 or 5. Attention Deficit Hyperactivity Disorder behavior problems were assessed using the Child Behavior Checklist and the Conners Parent Rating Scale- Revised. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26145720"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26145720/T_helper_type_2_polarization_among_asthmatics_during_and_following_pregnancy"><img alt="Research paper thumbnail of T-helper type 2 polarization among asthmatics during and following pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/46478261/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26145720/T_helper_type_2_polarization_among_asthmatics_during_and_following_pregnancy">T-helper type 2 polarization among asthmatics during and following pregnancy</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RastogiDeepa">Deepa Rastogi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Clinical <html_ent glyph="@amp;" ascii="&amp;"/> Experimental Allergy</span><span>, 2006</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bc82cd548314c35349ca8a8ab5c53ac3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46478261,"asset_id":26145720,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46478261/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26145720"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26145720"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26145720; 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While increased production of T helper cytokines has been reported to occur in both asthma and pregnancy, the effect of T-helper type 2 (Th2) polarization on asthma symptoms during pregnancy has not been well-characterized. Objective We hypothesized that systemic Th2 cytokine and chemokine polarization occurs among asthmatics to a greater extent during their pregnancy, and is associated with more severe asthma and increased Th2 polarization in the newborn. Methods Fifty-six pregnant asthmatics were recruited from prenatal clinics affiliated with New York Presbyterian Hospital. Systemic production of interleukin-4, interferon-g, eotaxin and IP10 were measured by intracytoplasmic staining or ELISA at recruitment, peripartum and post-partum, and in the cord blood. The frequency of asthma symptoms was measured by questionnaires and compared with Th biomarkers. Results The chemokine ratio (IP10/eotaxin) declined over the course of pregnancy (from 3.3 AE 1.3 to 1.4 AE 0.2, P = 0.016), but IP10 and eotaxin increased post-partum. The decrease in the chemokine ratio was associated with more frequent asthma symptoms. A non-significant trend towards decreased interferon-g and increased interleukin-4 production was detected. Cord blood eotaxin levels correlated with maternal levels (r = 0.35, P = 0.03). Other peripartum biomarkers were not associated with Th2 polarization nor with subsequent respiratory symptoms in the newborn. Conclusions IP10/eotaxin declined over the course of pregnancy and was associated with worse asthma symptoms. Alterations of Th1/Th2 chemokine balance during pregnancy may identify women prone to more severe asthma during pregnancy.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Clinical \u003chtml_ent glyph=\"@amp;\" ascii=\"\u0026amp;\"/\u003e Experimental Allergy","grobid_abstract_attachment_id":46478261},"translated_abstract":null,"internal_url":"https://www.academia.edu/26145720/T_helper_type_2_polarization_among_asthmatics_during_and_following_pregnancy","translated_internal_url":"","created_at":"2016-06-14T08:01:02.210-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49867839,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":21299601,"work_id":26145720,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773777,"email":"m***n@uiowa.edu","display_order":0,"name":"Paul Rothman","title":"T-helper type 2 polarization among asthmatics during and following 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26145731/B_cell_priming_in_utero_to_influenza_vaccination_1"><img alt="Research paper thumbnail of B cell priming in utero to influenza vaccination*1" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26145731/B_cell_priming_in_utero_to_influenza_vaccination_1">B cell priming in utero to influenza vaccination*1</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RastogiDeepa">Deepa Rastogi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT RationaleInfluenza vaccination is recommended for women who are pregnant during the infl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT RationaleInfluenza vaccination is recommended for women who are pregnant during the influenza season. Nonetheless, the development of B cell priming to influenza antigens in utero is controversial. We hypothesized that neonatal B cells will exhibit antigen specific immune responses following influenza vaccination of the pregnant mother.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26145731"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26145731"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26145731; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26145731]").text(description); $(".js-view-count[data-work-id=26145731]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26145731; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26145731']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26145731, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=26145731]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":26145731,"title":"B cell priming in utero to influenza vaccination*1","translated_title":"","metadata":{"abstract":"ABSTRACT RationaleInfluenza vaccination is recommended for women who are pregnant during the influenza season. 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We hypothesized that neonatal B cells will exhibit antigen specific immune responses following influenza vaccination of the pregnant mother.","internal_url":"https://www.academia.edu/26145731/B_cell_priming_in_utero_to_influenza_vaccination_1","translated_internal_url":"","created_at":"2016-06-14T08:01:03.149-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49867839,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":21299575,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":1462740,"email":"y***a@cchmc.org","display_order":0,"name":"Y. Ogawa","title":"B cell priming in utero to influenza vaccination*1"},{"id":21299576,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773769,"email":"d***e@chase.com","display_order":4194304,"name":"D. Blythe","title":"B cell priming in utero to influenza vaccination*1"},{"id":21299609,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":38212826,"co_author_invite_id":null,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia University","display_order":6291456,"name":"Rachel Miller","title":"B cell priming in utero to influenza vaccination*1"},{"id":21299612,"work_id":26145731,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773778,"email":"c***r@mssm.edu","display_order":7340032,"name":"Cynthia Lendor","title":"B cell priming in utero to influenza vaccination*1"}],"downloadable_attachments":[],"slug":"B_cell_priming_in_utero_to_influenza_vaccination_1","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":49867839,"first_name":"Deepa","middle_initials":null,"last_name":"Rastogi","page_name":"RastogiDeepa","domain_name":"independent","created_at":"2016-06-09T14:15:31.570-07:00","display_name":"Deepa Rastogi","url":"https://independent.academia.edu/RastogiDeepa"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":57433,"name":"Seasonality","url":"https://www.academia.edu/Documents/in/Seasonality"},{"id":587989,"name":"Influenza Vaccine","url":"https://www.academia.edu/Documents/in/Influenza_Vaccine"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="26145748"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/26145748/Antigen_specific_immune_responses_to_influenza_vaccine_in_utero"><img alt="Research paper thumbnail of Antigen-specific immune responses to influenza vaccine in utero" class="work-thumbnail" src="https://attachments.academia-assets.com/46478259/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/26145748/Antigen_specific_immune_responses_to_influenza_vaccine_in_utero">Antigen-specific immune responses to influenza vaccine in utero</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RastogiDeepa">Deepa Rastogi</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Journal of Clinical Investigation</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="57b98e710bbd07869b42c09087d95c51" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46478259,"asset_id":26145748,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46478259/download_file?st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&st=MTczMjQwNjI0OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="26145748"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="26145748"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 26145748; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=26145748]").text(description); $(".js-view-count[data-work-id=26145748]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 26145748; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='26145748']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 26145748, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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This paradigm remains controversial, however, due to the inability to identify antigen-specific T cells in cord blood. The advent of MHC tetramers has revolutionized the detection of antigen-specific T cells. Tetramer staining of cord blood after CMV infection has demonstrated that effective CD8 + antigen-specific immune responses can follow intrauterine viral infections. We hypothesized that sensitization to antigens occurs in utero in humans. We studied cord blood B and T cell immune responses following vaccination against influenza during pregnancy. Anti-Fluzone and anti-matrix protein IgM antibodies were detected in 38.5% (27 of 70) and 40.0% (28 of 70), respectively, of cord blood specimens. Using MHC tetramers, HA-specific CD4 + T cells were detected among 25.0% (3 of 12) and 42.9% (6 of 14) of cord blood specimens possessing DRB1*0101 and DRB1*0401 HLA types, respectively, and were detected even when the DRB1 HLA type was inherited from the father. Matrix protein-specific CD8 + T cells were detected among 10.0% (2 of 20) of HLA-A*0201 + newborns. These results","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Journal of Clinical Investigation","grobid_abstract_attachment_id":46478259},"translated_abstract":null,"internal_url":"https://www.academia.edu/26145748/Antigen_specific_immune_responses_to_influenza_vaccine_in_utero","translated_internal_url":"","created_at":"2016-06-14T08:01:04.580-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":49867839,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":21299602,"work_id":26145748,"tagging_user_id":49867839,"tagged_user_id":null,"co_author_invite_id":4773777,"email":"m***n@uiowa.edu","display_order":0,"name":"Paul Rothman","title":"Antigen-specific immune responses to influenza vaccine in utero"},{"id":21299610,"work_id":26145748,"tagging_user_id":49867839,"tagged_user_id":38212826,"co_author_invite_id":null,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia 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response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":280237,"name":"T lymphocytes","url":"https://www.academia.edu/Documents/in/T_lymphocytes"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":587989,"name":"Influenza Vaccine","url":"https://www.academia.edu/Documents/in/Influenza_Vaccine"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes"},{"id":1144154,"name":"Clinical Investigation","url":"https://www.academia.edu/Documents/in/Clinical_Investigation"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="20038907"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/20038907/Fractional_exhaled_nitric_oxide_exchange_parameters_among_9_year_old_inner_city_children"><img alt="Research paper thumbnail of Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children" class="work-thumbnail" src="https://attachments.academia-assets.com/41261893/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/20038907/Fractional_exhaled_nitric_oxide_exchange_parameters_among_9_year_old_inner_city_children">Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/DiurkaDiaz">Diurka Diaz</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/LHoepner">Lori Hoepner</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a></span></div><div class="wp-workCard_item"><span>Pediatric Pulmonology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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});</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 20038907, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ad1ba748c556e98872e0e63995a91310" } } $('.js-work-strip[data-work-id=20038907]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":20038907,"title":"Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children","translated_title":"","metadata":{"grobid_abstract":"Objectives and Hypothesis: To determine the feasibility of using a multiple flow offline fractional exhaled nitric oxide (FeNO) collection method in an inner-city cohort and determine this population's alveolar and conducting airway contributions of NO. We hypothesized that the flow independent NO parameters would be associated differentially with wheeze and seroatopy. Methods: As part of a birth cohort study, 9-year-old children (n ¼ 102) of African-American and Dominican mothers living in low-income NYC neighborhoods had FeNO samples collected offline at constant flow rates of 50, 83, and 100 ml/sec. Seroatopy was defined as having measurable (!0.35 IU/ml) specific IgE to any of the five inhalant indoor allergens tested. Current wheeze (last 12 months) was assessed by ISAAC questionnaire. Bronchial NO flux (J NO ) and alveolar NO concentration (C alv ) were estimated by the Pietropaoli and Hogman methods. Results: Valid exhalation flow rates were achieved in 96% of the children. Children with seroatopy (53%) had significantly higher median J NO (522 pl/sec vs. 161 pl/sec, P \u003c 0.001) when compared to nonseroatopic children; however, median C alv was not significantly different between these two groups (5.5 vs. 5.8, P ¼ 0.644). Children with wheeze in the past year (21.6%) had significantly higher median C alv (8.4 ppb vs. 4.9 ppb, P \u003c 0.001), but not J NO (295 pl/sec vs. 165 pl/sec, P ¼ 0.241) when compared with children without wheeze. These associations remained stable after adjustment for known confounders/covariates. Conclusions: The multiple flow method was easily implemented in this pediatric inner-city cohort. In this study population, alveolar concentration of NO may be a better indicator of current wheeze than single flow FeNO. Pediatr Pulmonol.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Pediatric Pulmonology","grobid_abstract_attachment_id":41261893},"translated_abstract":null,"internal_url":"https://www.academia.edu/20038907/Fractional_exhaled_nitric_oxide_exchange_parameters_among_9_year_old_inner_city_children","translated_internal_url":"","created_at":"2016-01-05T08:06:20.167-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":40977206,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":12589623,"work_id":20038907,"tagging_user_id":40977206,"tagged_user_id":null,"co_author_invite_id":2442935,"email":"f***1@pop-csm-vif.cc.columbia.edu","display_order":0,"name":"Frederica Perera","title":"Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city 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York City","url":"https://www.academia.edu/Documents/in/New_York_City"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E"},{"id":189576,"name":"Pediatric","url":"https://www.academia.edu/Documents/in/Pediatric"},{"id":227842,"name":"Pediatric Pulmonology","url":"https://www.academia.edu/Documents/in/Pediatric_Pulmonology"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population"},{"id":1330083,"name":"Respiratory Sounds","url":"https://www.academia.edu/Documents/in/Respiratory_Sounds"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"},{"id":1840211,"name":"Pulmonary Gas Exchange","url":"https://www.academia.edu/Documents/in/Pulmonary_Gas_Exchange"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="18225355"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/18225355/Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_%CE%B1_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients"><img alt="Research paper thumbnail of Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/18225355/Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_%CE%B1_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients">Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients</a></div><div class="wp-workCard_item"><span>International immunopharmacology</span><span>, Jan 21, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driv...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated inflammation, TNF-α mediated asthma inflammation is generally insensitive to inhaled corticosteroids (ICS). ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. It also suppresses both Th2 and TNF-α associated inflammation in murine asthma models. We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation. Until now, there are limited studies on anti-TNF-α compounds presented in ASHMITM. The objective of this study was to isolate and identify TNF-α inhibitory compounds in ASHMITM. Here we report that G. lucidum, but not the other ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="18225355"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="18225355"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18225355; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18225355]").text(description); $(".js-view-count[data-work-id=18225355]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18225355; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='18225355']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 18225355, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=18225355]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":18225355,"title":"Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients","translated_title":"","metadata":{"abstract":"Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated inflammation, TNF-α mediated asthma inflammation is generally insensitive to inhaled corticosteroids (ICS). ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. It also suppresses both Th2 and TNF-α associated inflammation in murine asthma models. We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation. Until now, there are limited studies on anti-TNF-α compounds presented in ASHMITM. The objective of this study was to isolate and identify TNF-α inhibitory compounds in ASHMITM. Here we report that G. lucidum, but not the other ...","publication_date":{"day":21,"month":1,"year":2015,"errors":{}},"publication_name":"International immunopharmacology"},"translated_abstract":"Asthma is a heterogeneous airway inflammatory disease, which is associated with Th2 cytokine-driven inflammation and non-Th2, TNF-α mediated inflammation. Unlike Th2 mediated inflammation, TNF-α mediated asthma inflammation is generally insensitive to inhaled corticosteroids (ICS). ASHMITM, aqueous extract of three medicinal herbs-Ganoderma lucidum (G. lucidum), Sophora flavescens Ait (S. flavescens) and Glycyrrhiza uralensis Fischer (G. uralensis), showed a high safety profile and was clinically beneficial in asthma patients. It also suppresses both Th2 and TNF-α associated inflammation in murine asthma models. We previously determined that G. uralensis flavonoids are the key active compounds responsible for ASHMITM suppression of Th2 mediated inflammation. Until now, there are limited studies on anti-TNF-α compounds presented in ASHMITM. The objective of this study was to isolate and identify TNF-α inhibitory compounds in ASHMITM. Here we report that G. lucidum, but not the other ...","internal_url":"https://www.academia.edu/18225355/Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_%CE%B1_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients","translated_internal_url":"","created_at":"2015-11-12T12:48:53.943-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":9593830,"work_id":18225355,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":2188960,"email":"d***n@mssm.edu","display_order":0,"name":"David Dunkin","title":"Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients"},{"id":9593862,"work_id":18225355,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":87534,"email":"x***i@mssm.edu","display_order":4194304,"name":"Xiu-min Li","title":"Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients"}],"downloadable_attachments":[],"slug":"Ganoderic_acid_C1_isolated_from_the_anti_asthma_formula_ASHMI_suppresses_TNF_α_production_by_mouse_macrophages_and_peripheral_blood_mononuclear_cells_from_asthma_patients","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[],"research_interests":[{"id":26699,"name":"Immunopharmacology","url":"https://www.academia.edu/Documents/in/Immunopharmacology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="18225354"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/18225354/Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ"><img alt="Research paper thumbnail of Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/18225354/Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ">Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ</a></div><div class="wp-workCard_item"><span>Neurotoxicology and Teratology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Tox...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed between groups of children whose mothers reported high vs. low material hardship during their pregnancy and through child age 5. We tested statistical interactions between hardships and polycyclic aromatic hydrocarbons, as measured by DNA adducts in cord blood, to determine whether material hardship exacerbated the association between adducts and IQ scores. Prospective cohort. Participants were recruited from 1998 to 2006 and followed from gestation through age 7years. Urban community (New York City) PARTICIPANTS: A community-based sample of 276 minority urban youth EXPOSURE MEASURE: Polycyclic aromatic hydrocarbon-DNA adducts in cord blood as an individual biomarker of prenatal polycyclic aromatic hydrocarbon exposure. Maternal material hardship self-reported prenatally and at multiple timepoints through early childhood. Child IQ at 7years assessed using the Wechsler Intelligence Scale for Children. Significant inverse effects of high cord PAH-DNA adducts on full scale IQ, perceptual reasoning and working memory scores were observed in the groups whose mothers reported a high level of material hardship during pregnancy or recurring high hardship into the child&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s early years, and not in those without reported high hardship. Significant interactions were observed between high cord adducts and prenatal hardship on working memory scores (β=-8.07, 95% CI (-14.48, -1.66)) and between high cord adducts and recurrent material hardship (β=-9.82, 95% CI (-16.22, -3.42)). The findings add to other evidence that socioeconomic disadvantage can increase the adverse effects of toxic physical &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;stressors&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; like air pollutants. Observed associations between high cord adducts and reduced IQ were significant only among the group of children whose mothers reported high material hardship. These results indicate the need for a multifaceted approach to prevention.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="18225354"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="18225354"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18225354; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18225354]").text(description); $(".js-view-count[data-work-id=18225354]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18225354; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='18225354']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 18225354, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=18225354]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":18225354,"title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ","translated_title":"","metadata":{"abstract":"Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed between groups of children whose mothers reported high vs. low material hardship during their pregnancy and through child age 5. We tested statistical interactions between hardships and polycyclic aromatic hydrocarbons, as measured by DNA adducts in cord blood, to determine whether material hardship exacerbated the association between adducts and IQ scores. Prospective cohort. Participants were recruited from 1998 to 2006 and followed from gestation through age 7years. Urban community (New York City) PARTICIPANTS: A community-based sample of 276 minority urban youth EXPOSURE MEASURE: Polycyclic aromatic hydrocarbon-DNA adducts in cord blood as an individual biomarker of prenatal polycyclic aromatic hydrocarbon exposure. Maternal material hardship self-reported prenatally and at multiple timepoints through early childhood. Child IQ at 7years assessed using the Wechsler Intelligence Scale for Children. Significant inverse effects of high cord PAH-DNA adducts on full scale IQ, perceptual reasoning and working memory scores were observed in the groups whose mothers reported a high level of material hardship during pregnancy or recurring high hardship into the child\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s early years, and not in those without reported high hardship. Significant interactions were observed between high cord adducts and prenatal hardship on working memory scores (β=-8.07, 95% CI (-14.48, -1.66)) and between high cord adducts and recurrent material hardship (β=-9.82, 95% CI (-16.22, -3.42)). The findings add to other evidence that socioeconomic disadvantage can increase the adverse effects of toxic physical \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;stressors\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; like air pollutants. Observed associations between high cord adducts and reduced IQ were significant only among the group of children whose mothers reported high material hardship. These results indicate the need for a multifaceted approach to prevention.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Neurotoxicology and Teratology"},"translated_abstract":"Polycyclic aromatic hydrocarbons are common carcinogenic and neurotoxic urban air pollutants. Toxic exposures, including air pollution, are disproportionately high in communities of color and frequently co-occur with chronic economic deprivation. We examined whether the association between child IQ and prenatal exposure to polycyclic aromatic hydrocarbons differed between groups of children whose mothers reported high vs. low material hardship during their pregnancy and through child age 5. We tested statistical interactions between hardships and polycyclic aromatic hydrocarbons, as measured by DNA adducts in cord blood, to determine whether material hardship exacerbated the association between adducts and IQ scores. Prospective cohort. Participants were recruited from 1998 to 2006 and followed from gestation through age 7years. Urban community (New York City) PARTICIPANTS: A community-based sample of 276 minority urban youth EXPOSURE MEASURE: Polycyclic aromatic hydrocarbon-DNA adducts in cord blood as an individual biomarker of prenatal polycyclic aromatic hydrocarbon exposure. Maternal material hardship self-reported prenatally and at multiple timepoints through early childhood. Child IQ at 7years assessed using the Wechsler Intelligence Scale for Children. Significant inverse effects of high cord PAH-DNA adducts on full scale IQ, perceptual reasoning and working memory scores were observed in the groups whose mothers reported a high level of material hardship during pregnancy or recurring high hardship into the child\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s early years, and not in those without reported high hardship. Significant interactions were observed between high cord adducts and prenatal hardship on working memory scores (β=-8.07, 95% CI (-14.48, -1.66)) and between high cord adducts and recurrent material hardship (β=-9.82, 95% CI (-16.22, -3.42)). The findings add to other evidence that socioeconomic disadvantage can increase the adverse effects of toxic physical \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;stressors\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; like air pollutants. Observed associations between high cord adducts and reduced IQ were significant only among the group of children whose mothers reported high material hardship. These results indicate the need for a multifaceted approach to prevention.","internal_url":"https://www.academia.edu/18225354/Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ","translated_internal_url":"","created_at":"2015-11-12T12:48:53.767-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":38212826,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":9593737,"work_id":18225354,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":128915,"email":"f***1@columbia.cdu","display_order":0,"name":"Frederica Perera","title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ"},{"id":9593832,"work_id":18225354,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":424339,"email":"s***g@columbia.edu","display_order":4194304,"name":"Shuang Wang","title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ"},{"id":9593834,"work_id":18225354,"tagging_user_id":38212826,"tagged_user_id":null,"co_author_invite_id":424351,"email":"j***8@columbia.edu","display_order":6291456,"name":"Julie Herbstman","title":"Combined effects of prenatal polycyclic aromatic hydrocarbons and material hardship on child IQ"}],"downloadable_attachments":[],"slug":"Combined_effects_of_prenatal_polycyclic_aromatic_hydrocarbons_and_material_hardship_on_child_IQ","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":38212826,"first_name":"Rachel","middle_initials":null,"last_name":"Miller","page_name":"RachelMiller","domain_name":"columbia","created_at":"2015-11-12T12:48:03.947-08:00","display_name":"Rachel Miller","url":"https://columbia.academia.edu/RachelMiller"},"attachments":[],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14182763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14182763/Effects_of_Prenatal_Exposure_to_Air_Pollutants_Polycyclic_Aromatic_Hydrocarbons_on_the_Development_of_Brain_White_Matter_Cognition_and_Behavior_in_Later_Childhood"><img alt="Research paper thumbnail of Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14182763/Effects_of_Prenatal_Exposure_to_Air_Pollutants_Polycyclic_Aromatic_Hydrocarbons_on_the_Development_of_Brain_White_Matter_Cognition_and_Behavior_in_Later_Childhood">Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://mercy.academia.edu/KirwanWalsh">Kirwan Walsh</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://columbia.academia.edu/RachelMiller">Rachel Miller</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/VirginiaRauh">Virginia Rauh</a></span></div><div class="wp-workCard_item"><span>JAMA Psychiatry</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood. To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those abnormalities in school-age children. Cross-sectional imaging study in a representative community-based cohort followed up prospectively from the fetal period to ages 7 to 9 years. The setting was urban community residences and an academic imaging center. Participants included a sample of 40 minority urban youth born to Latina (Dominican) or African American women. They were recruited between February 2, 1998, and March 17, 2006. Morphological measures that index local volumes of the surface of the brain and of the white matter surface after cortical gray matter was removed. We detected a dose-response relationship between increased prenatal PAH exposure (measured in the third trimester but thought to index exposure for all of gestation) and reductions of the white matter surface in later childhood that were confined almost exclusively to the left hemisphere of the brain and that involved almost its entire surface. Reduced left hemisphere white matter was associated with slower information processing speed during intelligence testing and with more severe externalizing behavioral problems, including attention-deficit/hyperactivity disorder symptoms and conduct disorder problems. The magnitude of left hemisphere white matter disturbances mediated the significant association of PAH exposure with slower processing speed. In addition, measures of postnatal PAH exposure correlated with white matter surface measures in dorsal prefrontal regions bilaterally when controlling for prenatal PAH. Our findings suggest that prenatal exposure to PAH air pollutants contributes to slower processing speed, attention-deficit/hyperactivity disorder symptoms, and externalizing problems in urban youth by disrupting the development of left hemisphere white matter, whereas postnatal PAH exposure contributes to additional disturbances in the development of white matter in dorsal prefrontal regions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14182763"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14182763"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14182763; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14182763]").text(description); $(".js-view-count[data-work-id=14182763]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14182763; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14182763']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 14182763, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14182763]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14182763,"title":"Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood","translated_title":"","metadata":{"abstract":"Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood. To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those abnormalities in school-age children. Cross-sectional imaging study in a representative community-based cohort followed up prospectively from the fetal period to ages 7 to 9 years. The setting was urban community residences and an academic imaging center. Participants included a sample of 40 minority urban youth born to Latina (Dominican) or African American women. They were recruited between February 2, 1998, and March 17, 2006. Morphological measures that index local volumes of the surface of the brain and of the white matter surface after cortical gray matter was removed. We detected a dose-response relationship between increased prenatal PAH exposure (measured in the third trimester but thought to index exposure for all of gestation) and reductions of the white matter surface in later childhood that were confined almost exclusively to the left hemisphere of the brain and that involved almost its entire surface. Reduced left hemisphere white matter was associated with slower information processing speed during intelligence testing and with more severe externalizing behavioral problems, including attention-deficit/hyperactivity disorder symptoms and conduct disorder problems. The magnitude of left hemisphere white matter disturbances mediated the significant association of PAH exposure with slower processing speed. In addition, measures of postnatal PAH exposure correlated with white matter surface measures in dorsal prefrontal regions bilaterally when controlling for prenatal PAH. Our findings suggest that prenatal exposure to PAH air pollutants contributes to slower processing speed, attention-deficit/hyperactivity disorder symptoms, and externalizing problems in urban youth by disrupting the development of left hemisphere white matter, whereas postnatal PAH exposure contributes to additional disturbances in the development of white matter in dorsal prefrontal regions.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"JAMA Psychiatry"},"translated_abstract":"Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and neurotoxic environmental contaminants. Prenatal PAH exposure is associated with subsequent cognitive and behavioral disturbances in childhood. To identify the effects of prenatal PAH exposure on brain structure and to assess the cognitive and behavioral correlates of those abnormalities in school-age children. Cross-sectional imaging study in a representative community-based cohort followed up prospectively from the fetal period to ages 7 to 9 years. The setting was urban community residences and an academic imaging center. Participants included a sample of 40 minority urban youth born to Latina (Dominican) or African American women. They were recruited between February 2, 1998, and March 17, 2006. Morphological measures that index local volumes of the surface of the brain and of the white matter surface after cortical gray matter was removed. We detected a dose-response relationship between increased prenatal PAH exposure (measured in the third trimester but thought to index exposure for all of gestation) and reductions of the white matter surface in later childhood that were confined almost exclusively to the left hemisphere of the brain and that involved almost its entire surface. Reduced left hemisphere white matter was associated with slower information processing speed during intelligence testing and with more severe externalizing behavioral problems, including attention-deficit/hyperactivity disorder symptoms and conduct disorder problems. The magnitude of left hemisphere white matter disturbances mediated the significant association of PAH exposure with slower processing speed. In addition, measures of postnatal PAH exposure correlated with white matter surface measures in dorsal prefrontal regions bilaterally when controlling for prenatal PAH. Our findings suggest that prenatal exposure to PAH air pollutants contributes to slower processing speed, attention-deficit/hyperactivity disorder symptoms, and externalizing problems in urban youth by disrupting the development of left hemisphere white matter, whereas postnatal PAH exposure contributes to additional disturbances in the development of white matter in dorsal prefrontal regions.","internal_url":"https://www.academia.edu/14182763/Effects_of_Prenatal_Exposure_to_Air_Pollutants_Polycyclic_Aromatic_Hydrocarbons_on_the_Development_of_Brain_White_Matter_Cognition_and_Behavior_in_Later_Childhood","translated_internal_url":"","created_at":"2015-07-18T20:15:02.649-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33166329,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":3421383,"work_id":14182763,"tagging_user_id":33166329,"tagged_user_id":38212826,"co_author_invite_id":412844,"email":"r***4@cumc.columbia.edu","affiliation":"Columbia University","display_order":0,"name":"Rachel Miller","title":"Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later 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