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extract formulation</title> <meta name="description" content="Search results for: OTC Kampo extract formulation"> <meta name="keywords" content="OTC Kampo extract formulation"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="OTC Kampo extract formulation"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3242</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: OTC Kampo extract formulation</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3242</span> A Brief History of Kampo Extract Formulations for Prescription in Japan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kazunari%20Ozaki">Kazunari Ozaki</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitsuru%20Kageyama"> Mitsuru Kageyama</a>, <a href="https://publications.waset.org/abstracts/search?q=Kenki%20Miyazawa"> Kenki Miyazawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Yoshio%20Nakamura"> Yoshio Nakamura</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Kampo (Japanese Traditional medicine) is a medicine traditionally practiced in Japan, based on ancient Chinese medicine. Most Kampo doctors have used decoction of crude drug pieces for treatment. 93% of the Kampo drugs sold in Japan are Kampo products nowadays. Of all Kampo products, 81% of them are Kampo extract formulations for prescription, which is prepared in powdered or granulated form from medicinal crude drug extracts mixed with appropriate excipient. Physicians with medical license for Western medicine prescribe these Kampo extract formulations for prescription in Japan. Objectives: Our study aims at presenting a brief history of Kampo extract formulations for prescription in Japan. Methods: Systematic searches for relevant studies were conducted using not only printed journals but also electronic journals from the bibliographic databases, such as PubMed/Medline, Ichushi-Web, and university/institutional websites, as well as search engines, such as Google and Google Scholar. Results: The first commercialization of Kampo extract formulations for general use (or OTC (over-the-counter) Kampo extract formulation) was achieved after 1957. The number of drugs has been subsequentially increased, reaching 148 Kampo extract formulation for prescription currently. Conclusion: We provide a history of Kampo extract formulations for prescription in Japan. The originality of this research is that it analyzes the background history of Kampo in parallel with relevant transitions in the government and insurance systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=health%20insurance%20system" title="health insurance system">health insurance system</a>, <a href="https://publications.waset.org/abstracts/search?q=history" title=" history"> history</a>, <a href="https://publications.waset.org/abstracts/search?q=Kampo" title=" Kampo"> Kampo</a>, <a href="https://publications.waset.org/abstracts/search?q=Kampo%20extract%20formulation%20for%20prescription" title=" Kampo extract formulation for prescription"> Kampo extract formulation for prescription</a>, <a href="https://publications.waset.org/abstracts/search?q=OTC%20Kampo%20extract%20formulation" title=" OTC Kampo extract formulation"> OTC Kampo extract formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=pattern%20corresponding%20prescription%20%28Ho-sho-so-tai%29%20system" title=" pattern corresponding prescription (Ho-sho-so-tai) system"> pattern corresponding prescription (Ho-sho-so-tai) system</a> </p> <a href="https://publications.waset.org/abstracts/81559/a-brief-history-of-kampo-extract-formulations-for-prescription-in-japan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81559.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">286</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3241</span> In-Vivo Study of Annacardium occidentale L. Emulgel Extract Using Non-Invasive Probes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Akhtar%20Naveed">Akhtar Naveed</a>, <a href="https://publications.waset.org/abstracts/search?q=Kanwal%20Shahla"> Kanwal Shahla</a>, <a href="https://publications.waset.org/abstracts/search?q=Khan%20HMS"> Khan HMS</a>, <a href="https://publications.waset.org/abstracts/search?q=Rasool%20Fatima"> Rasool Fatima</a>, <a href="https://publications.waset.org/abstracts/search?q=Ijaz%20Shakeel"> Ijaz Shakeel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The focus of the study was to design, develop and characterize in vivo, a stable Emulgel formulation containing Anacardium occidentale L.(cashew extract) as an active ingredient. The formulation was prepared and kept at 8ºC, 25 ºC, 40ºC and 40ºC±RH for a period of 28 days. During this time period, stability, pH values, conductivity, organoleptic features (color, liquefaction, phase separation) were conducted at the intervals of day 1st, 2nd, 3rd , 7th, 14th and 28th days. In In vivo studies, the test formulation (5% Anacardium occidentale L, extract) and a base formulation (without cashew extract) were prepared and both were applied on cheek areas of healthy human female volunteers, after the skin sensitivity test of each volunteer, for a study period of 8 weeks after getting consent from them. Various parameters of skin like Melanin level, Erythema level, and skin elasticity were measured at regular time intervals. Results of the study were analyzed by statistical techniques i.e. Two Way ANOVA and paired sample t-test. The result showed significant results as the p ≤ 0.05. Findings of paired sample t-test explained that test formulation have profound effects on skin parameters when compared with control formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anacardium%20occientale%20L." title="Anacardium occientale L.">Anacardium occientale L.</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-oxidant" title=" anti-oxidant"> anti-oxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=cashew%20nut" title=" cashew nut"> cashew nut</a>, <a href="https://publications.waset.org/abstracts/search?q=emulgel" title=" emulgel"> emulgel</a> </p> <a href="https://publications.waset.org/abstracts/64048/in-vivo-study-of-annacardium-occidentale-l-emulgel-extract-using-non-invasive-probes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64048.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">325</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3240</span> In vivo Inhibition and Restoration of Acetyl Cholinesterase Activities in Induced Clarias Gariepinus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=T.%20O.%20Ikpesu">T. O. Ikpesu</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Tongo"> I. Tongo</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Ariyo"> A. Ariyo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study was conducted to assess the effects of an organophosphate pesticide glyphosate formulation on neurological enzymes in the brain, liver and serum of juvenile Clarias gariepinus, and also to examine the antidotal prospect of Garcinia kola seeds extract. The fish divided into five groups were exposed to different treatments of glyphosate formulation and Garcinia kola seeds extract. Acetyl cholinesterase activities in the brain, liver and serum of the fish were estimated in the experimental and control fishes on day -7, 14, 21 and of 28 by spectrophotometrical methods. The enzyme was significantly (p < 0.05) inhibited in glyphosate formulation test. The inhibition percentages of AChE ranged for the brain, liver and serum between 40.7–59.4%, 50-57% and 27.5–51.3%, respectively. The aberrated parameters were recovered in G. kola seeds extract treated aquaria, and was dose and time dependent. The present study demonstrated that in vivo glyphosate formulation exposure caused AChE inhibition in the brain, liver and the serum. The brain tissue, however, might be suggested as a good indicator tissue for aquatic pollutants exposure in the fish and G. kola seeds extract has shown to be a good remedy for neurology restoration in a noxious circumstance. The findings has shown that xenobiotics could be eliminated from aquatic organisms, especially fish, and could be put into practice in areas at risk of pollutants. This approach can reduce the risks of biomagnification of poison in sea food. Hence, formulation of this plant extracts into capsule should be encouraged and supported. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glyphosate" title="glyphosate">glyphosate</a>, <a href="https://publications.waset.org/abstracts/search?q=Clarias%20gariepinus" title=" Clarias gariepinus"> Clarias gariepinus</a>, <a href="https://publications.waset.org/abstracts/search?q=brain" title=" brain"> brain</a>, <a href="https://publications.waset.org/abstracts/search?q=Garcinia%20kola" title=" Garcinia kola"> Garcinia kola</a>, <a href="https://publications.waset.org/abstracts/search?q=acetyl%20cholinesterase" title=" acetyl cholinesterase"> acetyl cholinesterase</a>, <a href="https://publications.waset.org/abstracts/search?q=enzymes" title=" enzymes "> enzymes </a> </p> <a href="https://publications.waset.org/abstracts/9259/in-vivo-inhibition-and-restoration-of-acetyl-cholinesterase-activities-in-induced-clarias-gariepinus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">391</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3239</span> Superoxide Dismutase Activity of Male Rats after Administration of Extract and Nanoparticle of Ginger Torch Flower</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tresna%20Lestari">Tresna Lestari</a>, <a href="https://publications.waset.org/abstracts/search?q=Tita%20Nofianti"> Tita Nofianti</a>, <a href="https://publications.waset.org/abstracts/search?q=Ade%20Yeni%20Aprilia"> Ade Yeni Aprilia</a>, <a href="https://publications.waset.org/abstracts/search?q=Lilis%20Tuslinah"> Lilis Tuslinah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruswanto%20Ruswanto"> Ruswanto Ruswanto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticle formulation is often used to improve drug absorptivity, thus increasing the sharpness of the action. Ginger torch flower extract was formulated into nanoparticle form using poloxamer 1, 3 and 5%. The nanoparticle was then characterized by its particle size, polydispersity index, zeta potential, entrapment efficiency and morphological form by SEM. The result shows that nanoparticle formulations have particle size 134.7-193.1 nm, polydispersity index less than 0.5 for all formulations, zeta potential -41.0 - (-24.3) mV and entrapment efficiency 89.93-97.99 against flavonoid content with a soft surface and spherical form of particles. Methanolic extract of ginger torch flower could enhance superoxide dismutase activity by 1,3183 U/mL in male rats. Nanoparticle formulation of ginger torch extract is expected to increase the capability of the drug to enhance superoxide dismutase activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=superoxide%20dismutase" title="superoxide dismutase">superoxide dismutase</a>, <a href="https://publications.waset.org/abstracts/search?q=ginger%20torch%20flower" title=" ginger torch flower"> ginger torch flower</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticle" title=" nanoparticle"> nanoparticle</a>, <a href="https://publications.waset.org/abstracts/search?q=poloxamer" title=" poloxamer"> poloxamer</a> </p> <a href="https://publications.waset.org/abstracts/91992/superoxide-dismutase-activity-of-male-rats-after-administration-of-extract-and-nanoparticle-of-ginger-torch-flower" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/91992.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3238</span> Mothwash Formulation of Moringa Leaf (Moringa Oleifera) and Its Activity as an Antibacterial for Streptococcus Mutans</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amalia%20Dwi%20Berliyanti%20Amel">Amalia Dwi Berliyanti Amel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Streptococcus mutants bacteria are bacteria that are believed to be the cause of the growth of dental plaque which can further adversely affect dental caries if left unchecked. Previous research has shown that Moringa leaf extract can slow down the growth rate of this bacterium. This study aims to make the best formulation of mouthwash with the active ingredient of Moringa leaf extract based on its antibacterial and organoleptic test results. Nine mouthwash variations were carried out with two factors and three levels, namely a comparison of the concentration of sorbitol (A) with three levels namely 15% (A1), 20% (A2), and 25% (A3), and peppermint added (B) with three levels, namely 0.2% (B1), 0.25% (B2), and 0.3% (B3). The test parameters performed as the determination of the best mouthwash are based on physicochemical properties which include pH and viscosity as well as organoleptic test results which include color, viscosity, aroma, taste, sensation in the mouth, and general appearance. The results showed that the bright zone as a test for the antibacterial activity of Streptococcus mutants began to be seen at a concentration of 5%. Moringa leaf mouthwash formulation has a pH value between 6 - 7, with a control of 6. Whereas the mucosa leaf mouthwash vascularity produced between 1.1 - 1.7 cP with a control of 1.1 cP. Moringa leaf mouthwash and control have the same total number of microbes, namely 0 colonies / mL. Based on organoleptic tests performed with 20 panelists, it was shown that the best mouthwash formulation was formulation A1B3 with sorbitol composition 15% and peppermint 0.3%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibasteria" title="antibasteria">antibasteria</a>, <a href="https://publications.waset.org/abstracts/search?q=formula" title=" formula"> formula</a>, <a href="https://publications.waset.org/abstracts/search?q=moringa%20leaf" title=" moringa leaf"> moringa leaf</a>, <a href="https://publications.waset.org/abstracts/search?q=mouthwash" title=" mouthwash"> mouthwash</a> </p> <a href="https://publications.waset.org/abstracts/127602/mothwash-formulation-of-moringa-leaf-moringa-oleifera-and-its-activity-as-an-antibacterial-for-streptococcus-mutans" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127602.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3237</span> Grape Seed Extract and Zinc Containing Multivitamin-Mineral Nutritional Food Supplement Protects Heart against Myocardial Ischemic-Reperfusion Injury in Wistar Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20M.%20Satyam">S. M. Satyam</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20L.%20Bairy"> K. L. Bairy</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Pirasanthan"> R. Pirasanthan</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20L.%20Vaishnav"> R. L. Vaishnav</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Zincovit tablets have been used as nutritional food supplement over a prolonged period of time. The aim of the present study was to investigate the cardio-protective effect of combined formulation of grape seed extract and Zincovit tablets (40, 80 and 160 mg/kg) using a Langendorff model of ischemia-reperfusion in Wistar rats. Following 21 days of pre-treatment, combined formulation of grape seed extract and Zincovit tablets significantly attenuated ischemia-reperfusion induced cardiac injury in terms of increased coronary flow rate (p < 0.01), decreased creatine kinase activity in coronary effluent (p < 0.05), decreased MDA (p < 0.001), 4-HNE (p < 0.001) and increased protein thiol content (p < 0.01) in comparison with the untreated (control) group. This study opens an avenue to clinical studies to demonstrate the validity of this paradigm as a nutritional food supplement, which could improve the clinical outcome of patients subjected to percutaneous angioplasty. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=grape%20seed%20extract" title="grape seed extract">grape seed extract</a>, <a href="https://publications.waset.org/abstracts/search?q=myocardial%20ischemia-reperfusion%20injury" title=" myocardial ischemia-reperfusion injury"> myocardial ischemia-reperfusion injury</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=Zincovit%20tablets" title=" Zincovit tablets "> Zincovit tablets </a> </p> <a href="https://publications.waset.org/abstracts/13015/grape-seed-extract-and-zinc-containing-multivitamin-mineral-nutritional-food-supplement-protects-heart-against-myocardial-ischemic-reperfusion-injury-in-wistar-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13015.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">376</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3236</span> Formulation of Suppositories Using Allanblackia Floribunda Butter as a Base</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mary%20Konadu">Mary Konadu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The rectal route for drug administration is becoming attractive to drug formulators because it can avoid hepatic first-pass effects, decrease gastrointestinal side effects and avoid undesirable effects of meals on drug absorption. Suppositories have been recognized as an alternative to the oral route in situations such as when the patient is comatose, unable to swallow, or when the drug produces nausea or vomiting. Effective drug delivery with appropriate pharmaceutical excipient is key in the production of clinically useful preparations. The high cost of available excipients coupled with other disadvantages have led to the exploration of potential excipients from natural sources. Allanblackia floribunda butter, a naturally occurring lipid, is used for medicinal, culinary, and cosmetic purposes. Different extraction methods (solvent (hexane) extraction, traditional/hot water extraction, and cold/screw press extraction) were employed to extract the oil. The different extracts of A. floribunda oil were analyzed for their physicochemical properties and mineral content. The oil was used as a base to formulate Paracetamol and Diclofenac suppositories. Quality control test were carried out on the formulated suppositories. The %age oil yield for hexane extract, hot water extract, and cold press extract were 50.40 ±0.00, 37.36±0.00, and 20.48±0.00, respectively. The acid value, saponification value, iodine value and free fatty acid were 1.159 ± 0.065, 208.51 ± 8.450, 49.877 ± 0.690 and 0.583 ± 0.032 respectively for hexane extract; 3.480 ± 0.055, 204.672±2.863, 49.04 ± 0.76 and 1.747 ± 0.028 respectively for hot water/traditional extract; 4.43 ± 0.055, 192.05±1.56, 49.96 ± 0.29 and 2.23 ± 0.03 respectively for cold press extract. Calcium, sodium, magnesium, potassium, and iron were minerals found to be present in the A. floribunda butter extracts. The uniformity of weight, hardness, disintegration time, and uniformity of content were found to be within the acceptable range. The melting point ranges for all the suppositories were found to be satisfactory. The cumulative drug release (%) of the suppositories at 45 minutes was 90.19±0.00 (Hot water extract), 93.75±0.00 (Cold Pres Extract), and 98.16±0.00 (Hexane Extract) for Paracetamol suppositories. Diclofenac sodium suppositories had a cumulative %age release of 81.60±0.00 (Hot water Extract), 95.33±0.00 (Cold Press Extract), and 99.20±0.00 (Hexane Extract). The physicochemical parameters obtained from this study shows that Allanblackia floribunda seed oil is edible and can be used as a suppository base. The suppository formulation was successful, and the quality control tests conformed to Pharmacopoeia standard. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=allanblackia%20foribunda" title="allanblackia foribunda">allanblackia foribunda</a>, <a href="https://publications.waset.org/abstracts/search?q=paracetamol" title=" paracetamol"> paracetamol</a>, <a href="https://publications.waset.org/abstracts/search?q=diclofenac" title=" diclofenac"> diclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=suppositories" title=" suppositories"> suppositories</a> </p> <a href="https://publications.waset.org/abstracts/149691/formulation-of-suppositories-using-allanblackia-floribunda-butter-as-a-base" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149691.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3235</span> Contact Toxicity Effects of Different Formulations of Artemisia Absinthium Extracts on Rose Aphid</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Atapour">Maryam Atapour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Chemical pesticides, which are widely used in agriculture, cause problems such as soil and water pollution, reducing biodiversity and creating pest resistance. These problems have led to increased attention to alternative and more sustainable methods such as natural-based pesticides. Herbal pesticides have been developed based on essential oils or extracts from different parts of plants, such as leaves, roots, and flowers. Herbal pesticides are compatible with the environment and can be used in integrated pest management programs. Despite the many benefits, herbal pesticides, especially essential oil-based compounds, have low durability in the environment, and their production costs are high, so the use of herbal extracts with appropriate formulations is more justified in all aspects. In the current study and based on the results of previous studies, aqueous and 70% ethanolic extract of Artemisia absinthium L. was prepared by the percolation method and formulated as an emulsion and water-soluble powder. To produce powder formulation, 20% maltodextrin was used with the spray-dryer method. Different concentrations of these compounds were sprayed on bushes infected with rose aphid Macrosiphum rosae (L.). Sampling was done randomly and the percentage of aphids’ mortality was checked. The results showed that the use of different concentrations of ethanolic extracts created a significant difference in the mortality rate of aphids, while water-soluble powder formulation caused less mortality. The current results showed that the extract of this plant has practical usability to control aphids, and with the appropriate formulation, it can be used as a good alternative to chemical pesticides. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=contact%20toxicity" title="contact toxicity">contact toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=formulation" title=" formulation"> formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=extract" title=" extract"> extract</a>, <a href="https://publications.waset.org/abstracts/search?q=aphid" title=" aphid"> aphid</a>, <a href="https://publications.waset.org/abstracts/search?q=Artemisia%20absinthium." title=" Artemisia absinthium."> Artemisia absinthium.</a> </p> <a href="https://publications.waset.org/abstracts/187446/contact-toxicity-effects-of-different-formulations-of-artemisia-absinthium-extracts-on-rose-aphid" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/187446.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">37</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3234</span> Delivery of Ginseng Extract Containing Phytosome Loaded Microsphere System: A Preclinical Approach for Treatment of Neuropathic Pain in Rodent Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nitin%20Kumar">Nitin Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: The current research work focuses mainly on evolving a delivery system for ginseng extract (GE), which in turn will ameliorate the neuroprotective potential by means of enhancing the ginsenoside (Rb1) bio-availability (BA). For more noteworthy enhancement in oral bioavailability (OBA) along with pharmacological properties, the drug carriers’ performance can be strengthened by utilizing phytosomes-loaded microspheres (PM) delivery system. Methods: For preparing the disparate phytosome complexes (F1, F2, and F3), an aqueous extract of ginseng roots (GR) along with phospholipids were reacted in disparate ratio. Considering the outcomes, F3 formulation (spray-dried) was chosen for preparing the phytosomes powder (PP), PM, and extract microspheres (EM). PM was made by means of loading of F3 into Gum Arabic (GA) in addition to maltodextrin polymer mixture, whereas EM was prepared by means of the addition of extract directly into the same polymer mixture. For investigating the neuroprotective effect (NPE) in addition to their pharmacokinetic (PK) properties, PP, PM, and EM formulations were assessed. Results: F3 formulation gave enhanced entrapment efficiency (EE) (i.e., 50.61%) along with good homogeneity of spherical shaped particle size (PS) (42.58 ± 1.4 nm) with least polydispersity index (PDI) (i.e., 0.193 ± 0.01). The sustained release (up to 24 h) of ginsenoside Rb1 (GRb1) is revealed by the dissolution study of PM. A significantly (p < 0.05) greater anti-oxidant (AO) potential of PM can well be perceived as of the diminution in the lipid peroxidase level in addition to the rise in the glutathione superoxide dismutase (SOD) in addition to catalase levels. It also showed a greater neuroprotective potential exhibiting significant (p < 0.05) augmentation in the nociceptive threshold together with the diminution in damage to nerves. A noteworthy enhancement in the relative BA (157.94%) of GRb1 through the PM formulation can well be seen in the PK studies. Conclusion: It is exhibited that the PM system is an optimistic and feasible strategy to enhance the delivery of GE for the effectual treatment of neuropathic pain. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ginseng" title="ginseng">ginseng</a>, <a href="https://publications.waset.org/abstracts/search?q=neuropathic" title=" neuropathic"> neuropathic</a>, <a href="https://publications.waset.org/abstracts/search?q=phytosome" title=" phytosome"> phytosome</a>, <a href="https://publications.waset.org/abstracts/search?q=pain" title=" pain"> pain</a> </p> <a href="https://publications.waset.org/abstracts/139025/delivery-of-ginseng-extract-containing-phytosome-loaded-microsphere-system-a-preclinical-approach-for-treatment-of-neuropathic-pain-in-rodent-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139025.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">187</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3233</span> Finite Element Approximation of the Heat Equation under Axisymmetry Assumption</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Raphael%20Zanella">Raphael Zanella</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This works deals with the finite element approximation of axisymmetric problems. The weak formulation of the heat equation under the axisymmetry assumption is established for continuous finite elements. The weak formulation is implemented in a C++ solver with implicit march-in-time. The code is verified by space and time convergence tests using a manufactured solution. The solving of an example problem with an axisymmetric formulation is compared to that with a full-3D formulation. Both formulations lead to the same result, but the code based on the axisymmetric formulation is much faster due to the lower number of degrees of freedom. This confirms the correctness of our approach and the interest in using an axisymmetric formulation when it is possible. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=axisymmetric%20problem" title="axisymmetric problem">axisymmetric problem</a>, <a href="https://publications.waset.org/abstracts/search?q=continuous%20finite%20elements" title=" continuous finite elements"> continuous finite elements</a>, <a href="https://publications.waset.org/abstracts/search?q=heat%20equation" title=" heat equation"> heat equation</a>, <a href="https://publications.waset.org/abstracts/search?q=weak%20formulation" title=" weak formulation"> weak formulation</a> </p> <a href="https://publications.waset.org/abstracts/143012/finite-element-approximation-of-the-heat-equation-under-axisymmetry-assumption" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143012.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">203</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3232</span> Ointment of Rosella Flower Petals Extract (Hibiscus sabdariffa): Pharmaceutical Preparations Formulation Development of Herbs for Antibacterial S. aureus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muslihatus%20Syarifah">Muslihatus Syarifah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Rosella flower petals can be used as an antibacterial because it contains alkaloids, flavonoids, phenolics, and terpenoids) for the . Bacteria activity is S. aureus can cause skin infections and pengobatanya most appropriate use of topical preparations. Ointment is a topical preparation comprising the active substance and ointment base. Not all the base matches the active substances or any type of disease. In this study using flavonoid active substances contained in rosella flower petals (Hibiscus sabdariffa) to be made ointment by testing a variety of different bases in order to obtain a suitable basis for the formulation of ointment extract rosella flower petals. Methods: Experimental research with research methods Post test control group design using the ointment is hydrocarbon sample, absorption, leached water and dissolved water. Then tested for bacteria S. aureus with different concentrations of 1%, 2%, 4%, 8%, 16, 32%. Data were analyzed using One Way ANOVA followed by Post Hoc test. Results: Ointment with a hydrocarbon base, absorption, leached water and dissolved water having no change in physical properties during storage. Base affect the physical properties of an ointment that adhesion, dispersive power and pH. The physical properties of the ointment with different concentrations produce different physical properties including adhesion, dispersive power and pH. The higher the concentration the higher dispersive power, but the smaller the adhesion and pH. Conclusion: Differences bases, storage time, the concentration of the extract can affect the physical properties of the ointment. Concentration of extract in the ointment extract rosella flower petals is 32%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=rosella" title="rosella">rosella</a>, <a href="https://publications.waset.org/abstracts/search?q=physical%20properties" title=" physical properties"> physical properties</a>, <a href="https://publications.waset.org/abstracts/search?q=ointments" title=" ointments"> ointments</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a> </p> <a href="https://publications.waset.org/abstracts/31964/ointment-of-rosella-flower-petals-extract-hibiscus-sabdariffa-pharmaceutical-preparations-formulation-development-of-herbs-for-antibacterial-s-aureus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31964.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">371</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3231</span> Antimicrobial Activity of Biosynthesized Silver Nanoparticles with Handroanthus Chrysanthus Flower Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eduardo%20Padilla">Eduardo Padilla</a>, <a href="https://publications.waset.org/abstracts/search?q=Luis%20Daniel%20Rodriguez"> Luis Daniel Rodriguez</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivan%20Sanchez"> Ivan Sanchez</a>, <a href="https://publications.waset.org/abstracts/search?q=Angelica%20Sofia%20Go"> Angelica Sofia Go</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The synthesis and application of metallic nanoparticles have increased in recent years. Biological methods go beyond the chemical and physical synthesis that is expensive and not friendly to the environment. Therefore, in this study, silver nanoparticles were synthesized biologically in an environmentally friendly way by Handroanthus chrysanthus flower aqueous extract (AgNPs) that contains phytochemicals capable of reducing silver nitrate. AgNPs were characterized visually by UV-visible spectroscopy and TEM. The antimicrobial activity of the AgNPs was tested by determining the minimum inhibitory concentration (MIC), and minimal bactericidal concentration (MBC) in Escherichia coli and Staphylococcus aureus strains AgNPs showed potent antimicrobial activity against gram-negative and gram-positive bacteria. MIC and MBC values were as low as 41.6, and 83.2 ug/mL using AgNPs biosynthesized by H. chrysanthus flower extract. This nanoparticle could be the basis for the formulation of disinfectants for use in the food and pharmaceutical industry. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title="antimicrobial">antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=silver%20nanoparticles" title=" silver nanoparticles"> silver nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=flower%20extract" title=" flower extract"> flower extract</a>, <a href="https://publications.waset.org/abstracts/search?q=Handroanthus" title=" Handroanthus"> Handroanthus</a> </p> <a href="https://publications.waset.org/abstracts/161062/antimicrobial-activity-of-biosynthesized-silver-nanoparticles-with-handroanthus-chrysanthus-flower-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/161062.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3230</span> Phytochemical Screening and Toxicological Studies of Aqueous Stem Bark Extract of Boswellia papyrifera (DEL) in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Abdulmumin">Y. Abdulmumin</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20I.%20Matazu"> K. I. Matazu</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20Wudil"> A. M. Wudil</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20J.%20Alhassan"> A. J. Alhassan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20A.%20Imam"> A. A. Imam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical analysis of Boswellia papryfera confirms the presence of various phytochemicals such as alkaloids, flavonoids, tannins, saponins and cardiac glycosides in its aqueous stem bark extract at different concentration, with tannins being the highest (0.611 ± 0.002 g %). Acute toxicity test (LD50,oral, rat) of the extract showed no mortality at up to 5000 mg/kg and the animals were found active and healthy. The extract was declared as practically non-toxic, this suggest the safety of the extract in traditional medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title="acute toxicity">acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title=" aqueous extract"> aqueous extract</a>, <a href="https://publications.waset.org/abstracts/search?q=boswellia%20papryfera" title=" boswellia papryfera"> boswellia papryfera</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20bark%20extract" title=" stem bark extract"> stem bark extract</a> </p> <a href="https://publications.waset.org/abstracts/34096/phytochemical-screening-and-toxicological-studies-of-aqueous-stem-bark-extract-of-boswellia-papyrifera-del-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34096.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">427</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3229</span> Comparative Antibacterial Property of Matured Trunk and Stem Bark Extract of Tamarindus indica L., Preformulation, Development and Quality Control of Cream</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20T.%20Jacinto">A. M. T. Jacinto</a>, <a href="https://publications.waset.org/abstracts/search?q=M.O.%20Osi"> M.O. Osi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tamarind has various medicinal properties among which is its antibacterial property. Its bark contains saponins, alkaloids, sesquiterpenes and tannins. It is rich in phlobapenes which is responsible for antibacterial property. The objective of the study was to determine which bark will produce the highest antibacterial property, develop it into a topical cream and evaluate its quality and characteristics. Powdered barks of Tamarind were extracted by soxhlet method using 70% acetone. Stem bark produced a higher yield than trunk bark (5.85 g vs. 4.73 g). It was found that the trunk bark was more sensitive than stem bark to microorganisms namely Staphylococcus aureus, Corynebacterium minutissimum, and Streptococcus spp. Sensitivity of trunk bark can be attributed to a more developed phytoconstituents. Dermal sensitization test on both sexes of rabbits using the following concentrations: 100%, 40% and 20% of extract showed that Tamarind has no irritating property and therefore safe for formulation into an antibacterial cream. Excipients used for formulation such as methyl paraben, propyl paraben, stearyl alcohol and white petrolatum were compatible with the Tamarind acetone extract through Differential Scanning Calorimetry except sodium lauryl sulfate that exhibited crystallization when subjected at 200˚C. The method of manufacture used in cream is fusion, therefore strict compliance of processing temperature should be observed to prevent polymorphism. Quality control tests of formulated cream based on USP 30 and Philippine Pharmacopeia were satisfactory. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title="antibacterial">antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=differential%20scanning%20calorimetry" title=" differential scanning calorimetry"> differential scanning calorimetry</a>, <a href="https://publications.waset.org/abstracts/search?q=tannins" title=" tannins"> tannins</a>, <a href="https://publications.waset.org/abstracts/search?q=dermal%20sensitization" title=" dermal sensitization"> dermal sensitization</a> </p> <a href="https://publications.waset.org/abstracts/16974/comparative-antibacterial-property-of-matured-trunk-and-stem-bark-extract-of-tamarindus-indica-l-preformulation-development-and-quality-control-of-cream" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16974.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">486</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3228</span> Phytochemical and in vitro Antimicrobial Screening of Extract of Sunflower Chrysanthlum indicum</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Ibrahim">I. Ibrahim</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Mann"> A. Mann</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical screening of crude Chrysanthlum Indicum revealed the presence of carbohydrates, flavonoids, saponins, tannins, alkanoids, steroidal nucleus and cardiac glycosides. The extract was evaluated against some pathogenic organisms by agar dilution method. The minimum inhibitory concentration and minimum bacteriocidal concentration (MBC) of the active extract of Chrysanthlum Indicum shows that its extract could be a potential source of antimicrobial agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=extract" title="extract">extract</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=Chrysanthlum%20indicum" title=" Chrysanthlum indicum "> Chrysanthlum indicum </a> </p> <a href="https://publications.waset.org/abstracts/15042/phytochemical-and-in-vitro-antimicrobial-screening-of-extract-of-sunflower-chrysanthlum-indicum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15042.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">570</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3227</span> Phytochemical Screening and Toxicological Studies of Aqueous Stem Bark Extract of Boswellia papyrifera (DEL) in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Abdulmumin">Y. Abdulmumin</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20I.%20Matazu"> K. I. Matazu</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20Wudil"> A. M. Wudil</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20J.%20Alhassan"> A. J. Alhassan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20A.%20Imam"> A. A. Imam </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical analysis of Boswellia papryfera confirms the presence of various phytochemicals such as alkaloids, flavonoids, tannins, saponins and cardiac glycosides in its aqueous stem bark extract at different concentration, with tannins being the highest (0.611 ± 0.002 g %). Acute toxicity test (LD50, oral, rat) of the extract showed no mortality at up to 5000 mg/kg and the animals were found active and healthy. The extract was declared as practically non-toxic, this suggest the safety of the extract in traditional medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title="acute toxicity">acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title=" aqueous extract"> aqueous extract</a>, <a href="https://publications.waset.org/abstracts/search?q=boswellia%20papryfera" title=" boswellia papryfera"> boswellia papryfera</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals%20and%20stem%20bark" title=" phytochemicals and stem bark"> phytochemicals and stem bark</a> </p> <a href="https://publications.waset.org/abstracts/34095/phytochemical-screening-and-toxicological-studies-of-aqueous-stem-bark-extract-of-boswellia-papyrifera-del-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34095.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3226</span> Antioxidant Activity of Nanoparticle of Etlingera elatior (Jack) R.M.Sm Flower Extract on Liver and Kidney of Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tita%20Nofianti">Tita Nofianti</a>, <a href="https://publications.waset.org/abstracts/search?q=Tresna%20Lestari"> Tresna Lestari</a>, <a href="https://publications.waset.org/abstracts/search?q=Ade%20Y.%20Aprillia"> Ade Y. Aprillia</a>, <a href="https://publications.waset.org/abstracts/search?q=Lilis%20Tuslinah"> Lilis Tuslinah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruswanto%20Ruswanto"> Ruswanto Ruswanto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticle technology gives a chance for drugs, especially natural based product, to give better activities than in its macromolecule form. The ginger torch is known to have activities as an antioxidant, antimicrobial, anticancer, etc. In this research, ginger torch flower extract was nanoparticlized using poloxamer 1, 3, and 5%. Nanoparticle was charaterized for its particle size, polydispersity index, zeta potential, entrapment efficiency, and morphological form by SEM (scanning electron microscope). The result shows that nanoparticle formulations have particle size 134.7-193.1 nm, polydispersity index is less than 0.5 for all formulations, zeta potential is -41.0 to (-24.3) mV, and entrapment efficiency is 89.93 to 97.99 against flavonoid content with a soft surface and spherical form of particles. Methanolic extract of ginger torch flower could enhance superoxide dismutase activity by 1,3183 U/mL in male rats. Nanoparticle formulation of ginger torch extract is expected to increase the capability of drug to enhance superoxide dismutase activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=superoxide%20dismutase" title="superoxide dismutase">superoxide dismutase</a>, <a href="https://publications.waset.org/abstracts/search?q=ginger%20torch%20flower" title=" ginger torch flower"> ginger torch flower</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticle" title=" nanoparticle"> nanoparticle</a>, <a href="https://publications.waset.org/abstracts/search?q=poloxamer" title=" poloxamer "> poloxamer </a> </p> <a href="https://publications.waset.org/abstracts/92307/antioxidant-activity-of-nanoparticle-of-etlingera-elatior-jack-rmsm-flower-extract-on-liver-and-kidney-of-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/92307.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">207</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3225</span> Antioxydant Activity of Flavonoïd’s Extracts of Rhamnus alaternus L. Leaves of Tessala Mountains (Occidental Algeria)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Benchiha%20Walid">Benchiha Walid</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahroug%20Samira"> Mahroug Samira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Rhamnus alaternus L. is a shrub that belongs to the family of Rhamnaceae. It is a medicinal plant that is largely used in traditional medicine in Algeria. Five flavonoic extracts obtained of Rhamnus alaternus L. leaves. The flavonoids were evaluated by a method that uses aluminum chloride AlCl3 of each extract; the content is estimated at 19.33 (Hexanic. Extract), 18.42 (Chlroformic.extract), 16.75 (Acetate. Extract), 3.9 (Brute. Extract), and 3.02 (Aqueous. Extract) mg Equivalent quercetine/gram of extract (mg QE/ g extract). The antioxidant activity was realized by the antiradical test that was evaluated by using DPHH (2.2 diphenyl-1-1picrylhdrazile), the inhibitory concentration at 50% (CI50) were estimated at 74.78 (Vitamin.C), 143.78 (Catechine), 101.78 (Gallic acid), 205.41 (Tannic acid), 210 (Caffeic acid) µg/ml; 74.16 (Br.extr), 9.98 (Aq.extr), 54.08 (Hèx.extr), 8.64 (Ac.extr), 30.49 (Ch.extr) mg/ml. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rhamnus%20alaternus%20L." title="Rhamnus alaternus L.">Rhamnus alaternus L.</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxydant%20activity" title=" antioxydant activity"> antioxydant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Tessala" title=" Tessala"> Tessala</a> </p> <a href="https://publications.waset.org/abstracts/31838/antioxydant-activity-of-flavonoids-extracts-of-rhamnus-alaternus-l-leaves-of-tessala-mountains-occidental-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31838.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">532</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3224</span> Antimicrobial Activity of the Natural Products Derived from Phyllanthus Emblica and Gracilaria Fisheri Against Staphylococcus Aureus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Woraprat%20Amnuaychaichana">Woraprat Amnuaychaichana</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Several medicinal plants are well known to contain active constituents such as flavonoids and phenolic compounds with are plausible candidates for therapeutic purposes. An infectious disease caused by microbial infection is the leading cause of death. Antibiotics are typically used to eradicate these microbes, but recent evidence indicates that they are developing antibiotic-resistant effects. This study focused on antimicrobial activities of Phyllanthus emblica and Gracilaria fisheri using the agar disk diffusion method and broth microdilution to determine the minimum inhibitory concentration (MIC) value. The extracts were screened against Staphylococcus aureus. Five concentrations of plant extracts were used to determine the minimum inhibitory concentration (MIC) by 2-fold dilution of plant extract. The results indicated that G. fisheri extract gave the maximum zones of inhibition of 11.7 mm against S. aureus while P. emblica showed no effects. The MIC values of G. fisheri extract against S. aureus was 500 µg/ml. To summarise, G. fisheri extracts demonstrated high efficacy of antibacterial activity against Gram-positive S. aureus, which may pave the way for developing a formulation containing this plant. G. fisheri extract should be subjected to additional investigation in order to determine the mechanism of action of its antimicrobial activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibacterial%20activity" title="antibacterial activity">antibacterial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Staphylococcus%20aureus" title=" Staphylococcus aureus"> Staphylococcus aureus</a>, <a href="https://publications.waset.org/abstracts/search?q=gracilaria%20fishery" title=" gracilaria fishery"> gracilaria fishery</a>, <a href="https://publications.waset.org/abstracts/search?q=Phyllanthus%20emblica" title=" Phyllanthus emblica"> Phyllanthus emblica</a> </p> <a href="https://publications.waset.org/abstracts/141049/antimicrobial-activity-of-the-natural-products-derived-from-phyllanthus-emblica-and-gracilaria-fisheri-against-staphylococcus-aureus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141049.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3223</span> Rapid Nanoparticle Formulation Development and Screening Using NanoFabTxTM Platform</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zhen%20Ye">Zhen Ye</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Zaroudi"> Maryam Zaroudi</a>, <a href="https://publications.waset.org/abstracts/search?q=Elizabeth%20Aisenbrey"> Elizabeth Aisenbrey</a>, <a href="https://publications.waset.org/abstracts/search?q=Nicolynn%20E.%20Davis"> Nicolynn E. Davis</a>, <a href="https://publications.waset.org/abstracts/search?q=Peng%20Gao"> Peng Gao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles have been used as drug delivery systems in the treatment of life-threatening diseases for decades, but traditional formulation development methods are time consuming and labor intensive. Millipore Sigma has developed a platform¬¬– NanoFabTxTM¬¬– for rapid and reproducible formulation development and screening to ensure consistentnanoparticle characteristics. Reproducible and precise control of the development process for a range of nanoparticle formulations accelerates the introduction of novel formulations to the clinic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bio%20platform" title="Bio platform">Bio platform</a>, <a href="https://publications.waset.org/abstracts/search?q=Formulation%20development" title=" Formulation development"> Formulation development</a>, <a href="https://publications.waset.org/abstracts/search?q=NanoFabTxTM" title=" NanoFabTxTM"> NanoFabTxTM</a>, <a href="https://publications.waset.org/abstracts/search?q=Drug%20delivery" title=" Drug delivery"> Drug delivery</a> </p> <a href="https://publications.waset.org/abstracts/154392/rapid-nanoparticle-formulation-development-and-screening-using-nanofabtxtm-platform" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154392.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">236</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3222</span> Formulation of Value Added Beff Meatballs with the Addition of Pomegranate (Punica granatum) Extract as a Source of Natural Antioxident</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20A.%20Hashem">M. A. Hashem</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Jahan"> I. Jahan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The experiment was conducted to find out the effect of different levels of Pomegranate (Punica granatum) extract and synthetic antioxidant BHA (Beta Hydroxyl Anisole) on fresh and preserved beef meatballs in order to make functional food. For this purpose, ground beef samples were divided into five treatment groups. They were treated as control group, 0.1% synthetic antioxidant group, 0.1%, 0.2% and 0.3% pomegranate extract group as T1, T2, T3, T4 and T5 respectively. Proximate analysis, sensory tests (color, flavor, tenderness, juiciness, overall acceptability), cooking loss, pH value, free fatty acids (FFA), thiobarbituric acid values (TBARS), peroxide value (POV) and microbiological examination were determined in order to evaluate the effect of pomegranate extract as natural antioxidant and antimicrobial activities compared to BHA (Beta Hydroxyl Anisole) at first day before freezing and for maintaining meatballs qualities on the shelf life of beef meat balls stored for 60 days under frozen condition. Freezing temperature was -20˚C. Days of intervals of experiment were on 0, 15th, 30th and 60th days. Dry matter content of all the treatment groups differ significantly (p<0.05). On the contrary, DM content increased significantly (p<0.05) with the advancement of different days of intervals. CP content of all the treatments were increased significantly (p<0.05) among the different treatment groups. EE and Ash content were decreased significantly (p<0.05) at different treatment levels. FFA values, TBARS, POV were decreased significantly (p<0.05) at different treatment levels. Color, odor, tenderness, juiciness, overall acceptability decreased significantly (p<0.05) at different days of intervals. Raw PH, cooked pH were increased at different treatment levels significantly (p<0.05). The cooking loss (%) at different treatment levels were differ significantly (p<0.05). TVC (logCFU/g), TCC (logCFU/g) and TYMC (logCFU/g) was decreased significantly (p<0.05) at different treatment levels and at different days of intervals comparison to control. Considering CP, tenderness, juiciness, overall acceptability, cooking loss, FFA, POV, TBARS value and microbial analysis it can be concluded that pomegranate extract at 0.1%, 0.2% and 0.3% can be used instead of synthetic antioxidant BHA in beef meatballs. On the basis of sensory evaluation, nutrient quality, physicochemical properties, biochemical analysis and microbial analysis 0.3% Pomegranate extract can be recommended for formulation of value added beef meatball enriched with natural antioxidant. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title="antioxidant">antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=pomegranate" title=" pomegranate"> pomegranate</a>, <a href="https://publications.waset.org/abstracts/search?q=BHA" title=" BHA"> BHA</a>, <a href="https://publications.waset.org/abstracts/search?q=value%20added%20meat%20products" title=" value added meat products"> value added meat products</a> </p> <a href="https://publications.waset.org/abstracts/42656/formulation-of-value-added-beff-meatballs-with-the-addition-of-pomegranate-punica-granatum-extract-as-a-source-of-natural-antioxident" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42656.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">246</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3221</span> Evaluation of the Nutritional Potential of a Developed Spice Formulation for nah poh (An Emulsion-Based Gravy): Physicochemical and Techno-Functional Characterisations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Djiazet%20St%C3%A8ve">Djiazet Stève</a>, <a href="https://publications.waset.org/abstracts/search?q=Mezajoug%20Kenfack%20Laurette%20Blandine"> Mezajoug Kenfack Laurette Blandine</a>, <a href="https://publications.waset.org/abstracts/search?q=Ravi%20Pullakhandam"> Ravi Pullakhandam</a>, <a href="https://publications.waset.org/abstracts/search?q=Bethala%20L.%20A.%20Prabhavathi%20Devi"> Bethala L. A. Prabhavathi Devi</a>, <a href="https://publications.waset.org/abstracts/search?q=Tchiegang%20Clerg%C3%A9"> Tchiegang Clergé</a>, <a href="https://publications.waset.org/abstracts/search?q=Prathapkumar%20Halady%20Shetty"> Prathapkumar Halady Shetty</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The nutritional potential of a developed spice formulation for nah poh was evaluated. It was found that when spices were used for the formulation for nah poh, the concentration of some nutrients is diluted while that of some of them increases. The proportion of unsaturated fats was estimated to be 76.2% of the total fat content while the chemical score varied between 31 to 39%. The contents of some essential minerals of nutritional interest in mg are as follows for 100g of spice: 2372.474 ± 0.007 for potassium, 16.447 ± 0.010 for iron, 4.772 ± 0.005 for zinc, 0.537 ± 0.001 for cupper, 0.138 ± 0.005 for selenium, and 112.954 ± 0.003 for manganese. This study shows that the consumption of these spices in the form of formulation significantly contributes to meet the mineral requirements of the populations whose food habits regularly require these spices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=spice%20formulation" title="spice formulation">spice formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=characterisation" title=" characterisation"> characterisation</a>, <a href="https://publications.waset.org/abstracts/search?q=nutritional%20potential" title=" nutritional potential"> nutritional potential</a>, <a href="https://publications.waset.org/abstracts/search?q=nah%20poh" title=" nah poh"> nah poh</a>, <a href="https://publications.waset.org/abstracts/search?q=techno%20functional%20properties" title=" techno functional properties"> techno functional properties</a> </p> <a href="https://publications.waset.org/abstracts/142085/evaluation-of-the-nutritional-potential-of-a-developed-spice-formulation-for-nah-poh-an-emulsion-based-gravy-physicochemical-and-techno-functional-characterisations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142085.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">227</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3220</span> Perspectives and Challenges Functional Bread with Yeast Extract to Improve Human Diet</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jelena%20Filipovi%C4%87">Jelena Filipović</a>, <a href="https://publications.waset.org/abstracts/search?q=Milenko%20Ko%C5%A1uti%C4%87"> Milenko Košutić</a>, <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20Filipovi%C4%87"> Vladimir Filipović</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the last decades, the urban population has been characterized by sedentary lifestyles, low physical activity, and "fast food". These changes in diet and physical nonactivity have been associated with an increase in chronic diseases. Bread is one of the most popular wheat products consumed worldwide. Spelt wheat has shown potential in various food applications, including bread, pasta, breakfast cereal, and other products of altered nutritional characteristics compared to conventional wheat products. It has very high protein content and even 30 to 60% higher concentration of mineral elements Fe, Zn, Cu, Mg and P compared to Triticum Aestivum. Spelt wheat is growing without the use of pesticides in harsh ecological conditions and it is an old cultivar. So it can be used for organic and health-safe food. Changes in the formulation of bread with the aim of improving its nutritional and functional properties usually lead to changes in the dough's properties, which are related to the quality of the finished product. The aim of this paper is to research the impact of adding yeast extract to bread on sensory characteristics and consumer acceptance of a new product as a key factor for the successful marketing of a distinct product. The sensory analysis of bread with 5% yeast extract is as follows: the technological quality is very good (3.8), and the color of the product is excellent (4.85). Based on data, consumers' survey declared that they liked the taste of bread with 5% yeast extract (74%), consumers marked the product as likable (70%), and 75% of the total number of respondents would buy this new product. This paper is promoting a type of bread with 5% yeast extract (Z score 0.80) to improve diet and a product intended for consumers conscious about their health and diet. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bread" title="bread">bread</a>, <a href="https://publications.waset.org/abstracts/search?q=yeast%20extract" title=" yeast extract"> yeast extract</a>, <a href="https://publications.waset.org/abstracts/search?q=sensory%20analysis" title=" sensory analysis"> sensory analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=consumer%20survey" title=" consumer survey"> consumer survey</a>, <a href="https://publications.waset.org/abstracts/search?q=score%20analysis" title=" score analysis"> score analysis</a> </p> <a href="https://publications.waset.org/abstracts/182434/perspectives-and-challenges-functional-bread-with-yeast-extract-to-improve-human-diet" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182434.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">60</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3219</span> Stilbenes as Sustainable Antimicrobial Compounds to Control Vitis Vinifera Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=David%20Taillis">David Taillis</a>, <a href="https://publications.waset.org/abstracts/search?q=Oussama%20Becissa"> Oussama Becissa</a>, <a href="https://publications.waset.org/abstracts/search?q=Julien%20Gabaston"> Julien Gabaston</a>, <a href="https://publications.waset.org/abstracts/search?q=Jean-Michel%20Merillon"> Jean-Michel Merillon</a>, <a href="https://publications.waset.org/abstracts/search?q=Tristan%20Richard"> Tristan Richard</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephanie%20Cluzet"> Stephanie Cluzet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nowadays, there is a strong pressure to reduce the phytosanitary inputs of synthetic chemistry in vineyards. It is, therefore, necessary to find viable alternatives in order to protect the vine against its major diseases. For this purpose, we suggest the use of a plant extract enriched in antimicrobial compounds. Being produced from vine trunks and roots, which are co-products of wine production, the extract produced is part of a circular economy. The antimicrobial molecules present in this plant material are polyphenols and, more particularly, stilbenes, which are derived from a common base, the resveratrol unit, and that are well known vine phytoalexins. The stilbenoids were extracted from trunks and roots (30/70, w/w) by a double extraction with ethyl acetate followed by enrichment by liquid-liquid extraction. The produced extract was characterized by UHPLC-MS, then its antimicrobial activities were tested on Plasmopara viticola and Botrytis cinerea in the laboratory and/or in greenhouse and in vineyard. The major compounds were purified, and their antimicrobial activity was evaluated on B. cinerea. Moreover, after its spraying, the effect of the stilbene extract on the plant defence status was evaluated by analysis of defence gene expression. UHPLC-MS analysis revealed that the extract contains 50% stilbenes with resveratrol, ε-viniferin and r-viniferin as major compounds. The extract showed antimicrobial activities on P. viticola with IC₅₀ and IC₁₀₀ respectively of 90 and 300 mg/L in the laboratory. In addition, it inhibited 40% of downy mildew development in greenhouse. However, probably because of the sensitivity of stilbenes to the environment, such as UV degradation, no activity has been observed in vineyard towards P. viticola development. For B. cinerea, the extract IC50 was 123 mg/L, with resveratrol and ε-viniferin being the most active stilbenes (IC₅₀ of 88 and 142 mg/L, respectively). The analysis of the expression of defence genes revealed that the extract can induce the expression of some defence genes 24, 48, and 72 hours after treatment, meaning that the extract has a defence-stimulating effect at least for the first three days after treatment. In conclusion, we produced a plant extract enriched in stilbenes with antimicrobial properties against two major grapevine pathogenic agents P. viticola and B. cinerea. In addition, we showed that this extract displayed eliciting activity of plant defences. This extract can therefore represent, after formulation development, a viable eco-friendly alternative for vineyard protection. Subsequently, the effect of the stilbenoid extract on primary metabolism will be evaluated by quantitative NMR. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title="antimicrobial">antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=bioprotection" title=" bioprotection"> bioprotection</a>, <a href="https://publications.waset.org/abstracts/search?q=grapevine" title=" grapevine"> grapevine</a>, <a href="https://publications.waset.org/abstracts/search?q=Plasmopara%20viticola" title=" Plasmopara viticola"> Plasmopara viticola</a>, <a href="https://publications.waset.org/abstracts/search?q=stilbene" title=" stilbene"> stilbene</a> </p> <a href="https://publications.waset.org/abstracts/126530/stilbenes-as-sustainable-antimicrobial-compounds-to-control-vitis-vinifera-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/126530.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">218</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3218</span> Perspectives and Challenges a Functional Bread With Yeast Extract to Improve Human Diet</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jelena%20Filipovi%C4%87">Jelena Filipović</a>, <a href="https://publications.waset.org/abstracts/search?q=Milenko%20Ko%C5%A1uti%C4%87"> Milenko Košutić</a>, <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20Filipovi%C4%87"> Vladimir Filipović</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the last decades urban population is characterized by sedentary lifestyles, low physical activity and "fast food". These changes in diet and physical non activity have been associated with the increase of chronic non diseases. Bread is one of the most popularly wheat products consumed worldwide. Spelt wheat has shown potential in various food applications, including bread, pasta, breakfast cereal and other products of altered nutritional characteristics compared to conventional wheat products. It has very high protein content and even 30 to 60% higher concentration of mineral elements Fe, Zn, Cu, Mg and P compared to Triticum Aestivum. Spelt wheat is growing without the use of pesticides in harsh ecological conditions and it is an old cultivar. So it can be used for organic and health safe food. Changes in the formulation of bread with the aim to improve their nutritional and functional properties usually lead to changes in the dough properties which is related reflected to the quality of the finished product. The aim of this paper is researching the impact of adding yeast extract to bread on sensory characteristics and consumer acceptance of a new product as a key factor for successful marketing of a new product. The sensory analysis of bread with 5% yeast extract is as follows: the technological quality is very good (3.8) and the color of the product is excellent (4.85). Based on data consumers survey declared that they liked the taste of bread with 5% yeast extract (74%), consumers marked the product as likeable (70%), and 75% of the total number of respondents would buy this new product. This paper is promoting a new type of bread with 5% yeast extract (Z score 0.80) to improve diet and novel functional product which intended for consumers conscious about their health and diet. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bread" title="bread">bread</a>, <a href="https://publications.waset.org/abstracts/search?q=yeast%20extract" title=" yeast extract"> yeast extract</a>, <a href="https://publications.waset.org/abstracts/search?q=sensory%20analysis" title=" sensory analysis"> sensory analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=consumer%20survey" title=" consumer survey"> consumer survey</a>, <a href="https://publications.waset.org/abstracts/search?q=score%20analysis%20Z" title=" score analysis Z"> score analysis Z</a> </p> <a href="https://publications.waset.org/abstracts/181543/perspectives-and-challenges-a-functional-bread-with-yeast-extract-to-improve-human-diet" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/181543.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">56</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3217</span> Multiobjective Optimization of a Pharmaceutical Formulation Using Regression Method</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=J.%20Satya%20Eswari">J. Satya Eswari</a>, <a href="https://publications.waset.org/abstracts/search?q=Ch.%20Venkateswarlu"> Ch. Venkateswarlu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The formulation of a commercial pharmaceutical product involves several composition factors and response characteristics. When the formulation requires to satisfy multiple response characteristics which are conflicting, an optimal solution requires the need for an efficient multiobjective optimization technique. In this work, a regression is combined with a non-dominated sorting differential evolution (NSDE) involving Naïve & Slow and ε constraint techniques to derive different multiobjective optimization strategies, which are then evaluated by means of a trapidil pharmaceutical formulation. The analysis of the results show the effectiveness of the strategy that combines the regression model and NSDE with the integration of both Naïve & Slow and ε constraint techniques for Pareto optimization of trapidil formulation. With this strategy, the optimal formulation at pH=6.8 is obtained with the decision variables of micro crystalline cellulose, hydroxypropyl methylcellulose and compression pressure. The corresponding response characteristics of rate constant and release order are also noted down. The comparison of these results with the experimental data and with those of other multiple regression model based multiobjective evolutionary optimization strategies signify the better performance for optimal trapidil formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pharmaceutical%20formulation" title="pharmaceutical formulation">pharmaceutical formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple%20regression%20model" title=" multiple regression model"> multiple regression model</a>, <a href="https://publications.waset.org/abstracts/search?q=response%20surface%20method" title=" response surface method"> response surface method</a>, <a href="https://publications.waset.org/abstracts/search?q=radial%20basis%20function%20network" title=" radial basis function network"> radial basis function network</a>, <a href="https://publications.waset.org/abstracts/search?q=differential%20evolution" title=" differential evolution"> differential evolution</a>, <a href="https://publications.waset.org/abstracts/search?q=multiobjective%20optimization" title=" multiobjective optimization"> multiobjective optimization</a> </p> <a href="https://publications.waset.org/abstracts/62859/multiobjective-optimization-of-a-pharmaceutical-formulation-using-regression-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/62859.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">409</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3216</span> Secondary Metabolite Profiling and Antimicrobial Activity of Leaf Extract of Tecomella undulata (Sm.) Seem</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Richa%20Bhardwaj">Richa Bhardwaj</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tecomella undulata (Sm.) Seem is a monotypic genus belonging to family Bignoniaceae. The plant holds tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The plant has gained prominence due to the presence of some prominent secondary metabolites. The present study focuses on the GC-MS analysis of leaf extracts of T. undulata which revealed the presence of certain bioactive compounds like stigmasterol, sitosterol, thiazoline, phytol, pthalic acid, methyl alpha ketopalmitate and so forth. A total of about 20 bioactive compounds were identified from the leaf extract spectra. Antimicrobial activity of the leaf extract was assayed against pathogenic bacteria and fungi. The alkaloids from leaf extracts showed antimicrobial activity against E.coli and B.subtilis. The flavonoids from leaves showed positive activity against Penicillium species and Candida albicans. The study thus infers that the presence of bioactive components may be the principle behind the antimicrobial property of different plant parts and therefore Tecomella forms a potential plant for herbal drug formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tecomella%20undulata" title="Tecomella undulata">Tecomella undulata</a>, <a href="https://publications.waset.org/abstracts/search?q=bioactive%20compounds" title=" bioactive compounds"> bioactive compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=GC-MS" title=" GC-MS"> GC-MS</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a> </p> <a href="https://publications.waset.org/abstracts/99645/secondary-metabolite-profiling-and-antimicrobial-activity-of-leaf-extract-of-tecomella-undulata-sm-seem" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/99645.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">150</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3215</span> Wound Healing and Antioxidant Properties of 80% Methanol Leaf Extract of Verbascum sinaiticum (Scrophulariaceae), an Ethiopian Medicinal Plant</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Solomon%20Assefa%20Huluka">Solomon Assefa Huluka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wounds account for severe morbidity, socioeconomic distress, and mortality around the globe.For several years, various herbal products are used to expediteand augment the innate wound healing process. In Ethiopian folkloricmedicine, Verbascum sinaiticum L. (V. sinaiticum) is commonlyapplied as a wound-healing agent. The present study investigated the potential wound healing and antioxidant properties of hydroalcoholic leaf extract of V. sinaiticum. The 80% methanol extract, formulated as 5% (w/w) and 10% (w/w) ointments, was evaluated in excision and incision wound models using nitrofurazone and simple ointment as positive and negative controls, respectively. Parameters such as wound contraction, period of epithelialization, and tensile strength were determined. Moreover, its in vitro antioxidant property was evaluated using a DPPH assay. In the excision model, both doses (5% and 10% w/w) of the extract showed a significant (p<0.001) wound healing efficacy compared to the negative control, as evidenced by enhanced wound contraction rate and shorter epithelialization time records. In the incision model, the lower dose (5% w/w) ointment formulation of the extract exhibited the maximum increment in tensile strength (85.6%) that was significant (p<0.001)compared to negative and untreated controls. Animals treated with 5% w/wointment, furthermore, showed a significantly (p < 0.05) higher percentage of tensile strength than nitrofurazone treated ones. Moreover, the hydroalcoholic extract of the plant showed a noticeable free radical scavenging property. The result of the present study upholds the folkloric use of V. sinaiticum in the treatment of wounds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title="wound healing">wound healing</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=excision%20wound%20model" title=" excision wound model"> excision wound model</a>, <a href="https://publications.waset.org/abstracts/search?q=incision%20wound%20model" title=" incision wound model"> incision wound model</a>, <a href="https://publications.waset.org/abstracts/search?q=verbascum%20sinaiticum" title=" verbascum sinaiticum"> verbascum sinaiticum</a> </p> <a href="https://publications.waset.org/abstracts/154687/wound-healing-and-antioxidant-properties-of-80-methanol-leaf-extract-of-verbascum-sinaiticum-scrophulariaceae-an-ethiopian-medicinal-plant" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154687.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">89</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3214</span> Screening for Larvicidal Activity of Aqueous and Ethanolic Extracts of Fourteen Selected Plants and Formulation of a Larvicide against Aedes aegypti (Linn.) and Aedes albopictus (Skuse) Larvae</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Michael%20Russelle%20S.%20Alvarez">Michael Russelle S. Alvarez</a>, <a href="https://publications.waset.org/abstracts/search?q=Noel%20S.%20Quiming"> Noel S. Quiming</a>, <a href="https://publications.waset.org/abstracts/search?q=Francisco%20M.%20Heralde"> Francisco M. Heralde</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study aims to: a) obtain ethanolic (95% EtOH) and aqueous extracts of <em>Selaginella elmeri, Christella dentata, Elatostema sinnatum, Curculigo capitulata, Euphorbia hirta, Murraya koenigii, Alpinia speciosa, Cymbopogon citratus, Eucalyptus globulus, Jatropha curcas, Psidium guajava, Gliricidia sepium, Ixora coccinea</em> and <em>Capsicum frutescens</em> and screen them for larvicidal activities against Aedes aegypti (Linn.) and Aedes albopictus (Skuse) larvae; b) to fractionate the most active extract and determine the most active fraction; c) to determine the larvicidal properties of the most active extract and fraction against by computing their percentage mortality, LC50, and LC90 after 24 and 48 hours of exposure; and d) to determine the nature of the components of the active extracts and fractions using phytochemical screening. Ethanolic (95% EtOH) and aqueous extracts of the selected plants will be screened for potential larvicidal activity against <em>Ae. aegypti</em> and <em>Ae. albopictus</em> using standard procedures and 1% malathion and a Piper nigrum based ovicide-larvicide by the Department of Science and Technology as positive controls. The results were analyzed using One-Way ANOVA with Tukey’s and Dunnett’s test. The most active extract will be subjected to partial fractionation using normal-phase column chromatography, and the fractions subsequently screened to determine the most active fraction. The most active extract and fraction were subjected to dose-response assay and probit analysis to determine the LC50 and LC90 after 24 and 48 hours of exposure. The active extracts and fractions will be screened for phytochemical content. The ethanolic extracts of <em>C. citratus, E. hirta, I. coccinea, G. sepium, M. koenigii, E globulus, J. curcas</em> and <em>C. frutescens</em> exhibited significant larvicidal activity, with <em>C. frutescens</em> being the most active. After fractionation, the ethyl acetate fraction was found to be the most active. Phytochemical screening of the extracts revealed the presence of alkaloids, tannins, indoles and steroids. A formulation using talcum powder–300 mg fraction per 1 g talcum powder–was made and again tested for larvicidal activity. At 2 g/L, the formulation proved effective in killing all of the test larvae after 24 hours. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=larvicidal%20activity%20screening" title="larvicidal activity screening">larvicidal activity screening</a>, <a href="https://publications.waset.org/abstracts/search?q=partial%20purification" title=" partial purification"> partial purification</a>, <a href="https://publications.waset.org/abstracts/search?q=dose-response%20assay" title=" dose-response assay"> dose-response assay</a>, <a href="https://publications.waset.org/abstracts/search?q=capsicum%20frutescens" title=" capsicum frutescens"> capsicum frutescens</a> </p> <a href="https://publications.waset.org/abstracts/37793/screening-for-larvicidal-activity-of-aqueous-and-ethanolic-extracts-of-fourteen-selected-plants-and-formulation-of-a-larvicide-against-aedes-aegypti-linn-and-aedes-albopictus-skuse-larvae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37793.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3213</span> Nanoemulsion Formulation of Ethanolic Extracts of Propolis and Its Antioxidant Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rachmat%20Mauludin">Rachmat Mauludin</a>, <a href="https://publications.waset.org/abstracts/search?q=Dita%20Sasri%20Primaviri"> Dita Sasri Primaviri</a>, <a href="https://publications.waset.org/abstracts/search?q=Irda%20Fidrianny"> Irda Fidrianny</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Propolis contains several antioxidant compounds which can be used in topical application to protect skin against free radical, prevent skin cancer and skin aging. Previous study showed that 70% ethanolic extract of propolis (EEP) provided the greatest antioxidant activity. Since EEP has very small solubility in water, the extract was prepared in nanoemulsion (NE). Nanoemulsion is chosen as cosmetic dosage forms according to its properties namely to decrease the risk of skin’s irritation, increase penetration, prolong its time to remain in our skin, and improve stability. Propolis was extracted using reflux methods and concentrated using rotavapor. EEP was characterized with several tests such as phytochemical screening, density, and antioxidant activity using DPPH method. Optimation of total surfactant, co-surfactant, oil, and amount of EEP that can be included in NE were required to get the best NE formulation. The evaluations included to organoleptic observation, globul size, polydispersity index, morphology using TEM, viscosity, pH, centrifuge, stability, Freeze and Thaw test, radical scavenging activity using DPPH method, and primary irritation test. The yield extracts was 11.12% from raw propolis contained of steroid/triterpenoid, flavonoid, and saponin based on phytochemical screening. EEP had the value of DPPH scavenging activity 61.14% and IC50 0.41629 ppm. The best NE formulation consisted of 26.25% Kolliphor RH40; 8.75% glycerine; 5% rice bran oil; and 3% EEP. NE was transparant, had globul size of 21.9 nm; polydispersity index of 0.338; and pH of 5.67. Based on TEM morphology, NE was almost spherical and has particle size below 50 nm. NE propolis revealed to be physically stable after stability test within 63 days at 25oC, centrifuged for 30 mins at 13.000 rpm, and passed 6 cycles of Freeze and Thaw test without separated. NE propolis reduced 58% of free radical DPPH similar to antioxidant activity of the original extracts. Antioxidant activity of NE propolis is relatively stable after stored for 6 weeks. NE Propolis was proven to be safe by primary irritation test with the value of primary irritation index (OECD) was 0. The best formulation for NE propolis contained of 26.25% Kolliphor RH40; 8.75% glycerine; 5% rice bran oil; and 3% EEP with globul size of 21.9 nm and polydispersity index of 0.338. NE propolis was stable and had antioxidant activity similar to EEP. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=propolis" title="propolis">propolis</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoemulsion" title=" nanoemulsion"> nanoemulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=irritation%20test" title=" irritation test"> irritation test</a> </p> <a href="https://publications.waset.org/abstracts/20332/nanoemulsion-formulation-of-ethanolic-extracts-of-propolis-and-its-antioxidant-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20332.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">305</span> </span> 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