CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'managed',cRay: '919fc70cab669fb5',cH: 'OvXq6qdl1K_zL08um8Qh4RWuP7OnkkGpl4EBAVIkcoM-1740906800-1.2.1.1-g1K8oo9dVehD7O9L2Fsu.x3MlL_GKrFeWtjWmIZz0Hjvq5sNP.F8l_QbkyVmvZtl',cUPMDTk: "\/abstracts\/search?q=sequence%20evolution&__cf_chl_tk=HeBTomVx1XhBhWLLk4I41WIttsfFt2urIR.v5ENkjGg-1740906800-1.0.1.1-HQlR7_4nFtH7YY7WUf9rYu4Zowm1xGboMqkMhqvgyNw",cFPWv: 'b',cITimeS: '1740906800',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/abstracts\/search?q=sequence%20evolution&__cf_chl_f_tk=HeBTomVx1XhBhWLLk4I41WIttsfFt2urIR.v5ENkjGg-1740906800-1.0.1.1-HQlR7_4nFtH7YY7WUf9rYu4Zowm1xGboMqkMhqvgyNw",md: "NIXAARByuBjZbjiQ_jp1zX0.Mq28FzHgQ92xFy7u3EI-1740906800-1.2.1.1-GA6YQGGVIckqtI9.6n9e_aM8zx78tpjfXCWGWg3EIhckBt0zYXw0q9GlL1SGffZC3VNI0a7Rz3JyJ.l5UYtXBqKsJu6dMWJhkmSZgAzYZrSpuFwAkJy6_crF1CImQzhewcQUKQqAsXIY1bQx2N.miU8.OnGJU3qTXHhZEpOc_RchqmEN5VkLwkeiFJFi4vegaVyQMYZTKAFlcuqwJCvYut0GZgUF5V7iUXl3G1KEoDLaE9jHUnZUeigeuTPHFi3nxPKUnEZRk1bXUA1caKBpdRZKvGFxXupF6hze8mQRILpyabVdz.TQ.LNOVXzIIHqnfPTN4ofvAZnf3Lmw0lcOxYvzHN18sMUiRMfKGmo7adELrD7wMyS_T1JsHFaM2.MhMEpjwxWGQx4z0RpT7eOR0c_W3HRAdMeUBcI3AzXxN1j3byrZMonp3We9lVm0.Ifhc98jrYcy.z_r5bJnogs2vbfOL0i0ZJZ50Sz3mE3pkGzdL0XxA38EmYitkFjZzfwwIVU23ZoD9.5glJ4VIRLcwqIJ9PWIEE7mDm5rWXdl8rZsFXj6X_1yQmBYPvoIQEUcm8zOKuvsiCHFWj8zSxaWfp5osYFZGFRFu4X4TOpj8SmhLe.Zn6Bs.JQXXieVJl86FHCYHv7ADpXH3Y2BMe2t.sO7WP9FUH.qXw.TZZWMg.AaMAkiJ8XPYhMb2_RbF0WSFKXP2alzNuCtnXugWBBLUl8OgY4TT1nnIrQGJxN0d7l7u32tsgg3Xfy0QSWweb5BvhS5MI0y9.J84BmIPHoZ7gSg7nmO4kU0_NrQRFIM9TCnmjw69RQiGDymo2ao2yg3ZR93PTa7N7FuHAiy9vWJoMTb9rmFd1JZCHMtbPnsMnLMiniG3zl12tq.HI77hc08KHhkmPit0MHAvLWNs1WpJqzZlEE3ciE7p5rp43PGOJX_HAMX_tZWrNrJekB3szMVsTF55m0gztk9sY9_u7q3T.mhEOvrIY0y6rm96yWo.MIuDoartU0bt6zqptMQAsoGjXVBoj2ZbPRYJY3wjHpWf53vlesEMU5eUPek3y.y9Vp.6TlxXi07J2Fwqz8cWbVDIM.Q8L8L6Cc66U72kYOlNHiIEFmuNLEtBboFMb4ePKKDxU2hTjINCjEj16ycOXbEWFosGH2bNasWCctmZ0CfBcguk0xGlmtp6M8MbKxIM5UVwz3C0PlgZxLHVNFOhKDti1E931euiiYEGqpM.1sEA6nIFG11AKmcQ8KHN6EwZBHCZikSR8dRnR59lF4NxIzPceV7TrZUNfABQjyAw9qLcSVVX9yxeiSq2ZtDRgQepec",mdrd: "D5CBZY_CaXIlA1ahZOFlknlNtisngiar19b896URQaI-1740906800-1.2.1.1-ErDNhLqdFZRx_ZUmk6KLba4tN2eOdZ_C1C7KosQr._BTsWtb8byu6v.fGR2cA..rK7tWdU7dXlatXuGzkj2K1IYNgFyu1iGVs35XBS_jYKF49a8tTVbjEZjAPRyVHwF.KZYf_eeCwXnE7OccFirFWSeXeSJ5hZ5LIvklP_0iF2bUgHVuCQ6BDytUhS8R79T9YFmjiQ_HQS2m1qR2iGlJoRNllVzXwJV2Y4OuMqKVepDImil7WXenBE.GUnBjC770NyrmML9Dm5AySB3PD.OH1cX8siQlzSNeASJTDsPZtc8DKAqlhSY604IJL1NAJPRHqJU6vOg87o0q0zEU9WWawyMKuUUIyOstgz0Q3pxQRYlcj5x5VmwebhCYnf4aTHIYLP.4O1Wl9VA29vlmDkCNIvV0M7TLtxDXXDftaoqx9QE6bx08nEN2mCFbUpzus3_uWL2q85mrI02SkeisNo3FLbNG5yT4yJ6EcGpwndsyHnPkLNdgBhW4LIBwOI1gWouHavGAMaeYOHWOs0UXZTxsjWcG_lKmZ5fs9MrX2sgRWSc_eoKKK_RlyX.C2OVAQxNLXoV6paQoEMZ0FwhcjxogsB_N5wsFoYYzt5i2wNTgmek3PgsXdnd0oTG50ScmpVC5f1cqKkFBCFMCc5ag_MAAZfHpfInSshabGR.e5Pk6Kw2drEloF1jb0Nhc2GQFWOYiqd.wy9XgWJf.KYLPSOnItuxtoVd6Sj6xQY16dCCcnc99f75Pk2m_fRHGRaNArFxaDrtWoQRxYJAIxvqJVyRCvvRFL0YLuEx0YYZhyYfB_H8TzXA0yxFWpiv_2xNgBOEvDYA86xDfUzV222F94Jy8PWVfi_RRZHVaBPf4RR7nIj1oVRstZJJgg0Wx2IV7tb91tNWQm2jsiRS80qw_ppUIOGHtiWcyfM3Se91BJvpVHg9zwFBHSOVZiBCHKNO7N_G53enZLnQN_yfCWf92.k_eSGSmg_XyWH11GDmYO7i5ztceAu9O.ksWZU.gCIlMl1vPABlk9kD6gdi05FYvlghI_iYMzdvOykvG1RDHtwUcrCkq4l4VboqqGJ8z3sVsXeOSvXp6jWkYVo.Zstbkgnjr5ucM173NomhCykhi89YDZQDD8uZe7wX7lTeoaP4rXqcSPHynAcvBGNJdhjC7H1ee6NSu6akKjaiF4MuvMAdwRkjZqxv6u8rcbs1T5J8u7pXubJCjuiAkw0C6uVBRClBmwTVxUOHWaZZ3EbsAVaU.OMgb9d2EqlHMvLvjG_QcjSwL7TJ4SBSUkvrw9A6en1f7SzsZAtuIoIhKGRhQv84BxvJZfwO5ROT5noKP0N6UMPILKIgt2j2c_Gd.lOJdcg37Q2b88M03oyWMJ6GITHH36exjTlcc._VmBUyngqJQ74a5X81RLNOei2kt8rqtLsfsz4GAwr815Pfq_kmUCpt67ukuar.p1viaT4ulgdugJVAIkueVasiiNfOekYpXKILA23_82Jm6NXDFPnKBEwjvQc_Qa3uBfM5NGantEAAfrIzvuR4XysYj0eh5.rIQzNSq.wxwym2ZA2YFDvY53z040OpQkuZ_MWqLJadoreimYvea_GoNZSYvSDw8RWEgezxqMFKbkxHgTLP08c.DjSd6M7lBAlciaZNXgMYCo0xfKklELXCUjC7oImiZF3F56ck4mBin5wd6c6.LsPioDejUcSXnP_eJgk4WlS68bEKxhkF6UYuto9ZiikYP7zD_U2DaOAAjev8abgLpioo4J3DmfRKSEEG79MSA1CcuMZj4BRtck1pf7DgXYAHM_VlkWeMPBy2ciVHxfVYn20hT0n7eITsZmitDrfFAA_lRrhpeXkh_Lhv0hpfGx.6iyV2B33a.66UvEHMtwJr5tKWeFXKoTUz_HHi.X67iSZfRou10mjk3e.WLXbA3E7mRLanBitiyfrH2Azzf9ExUjszg1SfuwoI15AVtCKPe.QRMtTss1cObp0jCmRy.YPl5QC6.OG_M1w"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=919fc70cab669fb5';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/search?q=sequence%20evolution&__cf_chl_rt_tk=HeBTomVx1XhBhWLLk4I41WIttsfFt2urIR.v5ENkjGg-1740906800-1.0.1.1-HQlR7_4nFtH7YY7WUf9rYu4Zowm1xGboMqkMhqvgyNw" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>