Paraneoplastic non-bacterial thrombotic endocarditis in a KR

<!DOCTYPE html> <html lang="zh"> <head> <title>Paraneoplastic non-bacterial thrombotic endocarditis in a KR | 27208</title> <meta name="keywords" content="James Mark Debono, Sara Micallef , Christa Marie Vella, Nicola Ding-li, Janabel Said , "/> <meta name="description" content="Marantic endocarditis, also known as Nonbacterial Thrombotic Endocarditis (NBTE), is a rare and complex disease which challenges clinicians and researchers..27208"/> <meta name="citation_publisher" content="科技" /> <meta name="citation_journal_title" content="临床肿瘤学：病例报告"> <meta name="citation_title" content="Paraneoplastic non-bacterial thrombotic endocarditis in a KRAS mutant pulmonary adenocarcinoma"> <meta name="citation_author" content="James Mark Debono" /> <meta name="citation_author" content="Sara Micallef " /> <meta name="citation_author" content="Christa Marie Vella" /> <meta name="citation_author" content="Nicola Ding-li" /> <meta name="citation_author" content="Janabel Said" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="7"> <meta name="citation_issue" content="11"> <meta name="citation_abstract" content="Marantic endocarditis, also known as Nonbacterial Thrombotic Endocarditis (NBTE), is a rare and complex disease which challenges clinicians and researchers alike due to its multifactorial aetiology, diverse clinical presentations, and limited available treatment options. Here we report a case of marantic endocarditis with cerebral, renal and peripheral vascular infarctions in a 43-years-old lady with a KRAS G12C mutant adenocarcinoma of the lung who presented with a left sided 7 th CN palsy, left upper and lower limb hemiplegia, complete aphasia and fixed right gaze palsy. Initial imaging showed findings suggestive of a thrombotic CVA and a thrombectomy was carried out. She subsequently suffered a series of thromboembolic phenomena including several Janeway lesions and splinter haemorrhages, right lower lobe lung infarction, right renal infarction and multiple bilateral cerebral infarctions. Infective endocarditis was suspected and TTE (transthoracic echocardiogram) showed aortic valve vegetations. However, serial blood cultures were negative. An aortic valve replacement was carried out which confirmed NBTE. She was later started on Sotorasib in an attempt to offer palliative control of her pulmonary adenocarcinoma. 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class="bg-color-sky-light"> <div class="content-md container border-bottom-1"> <div class="row"> <div class="col-sm-9"> <div class="margin-b-30"> <h2>Paraneoplastic non-bacterial thrombotic endocarditis in a KRAS mutant pulmonary adenocarcinoma</h2> <p><i class="fas fa-user"></i> James Mark Debono, Sara Micallef , Christa Marie Vella, Nicola Ding-li, Janabel Said </p> <p><p>Marantic endocarditis, also known as Nonbacterial Thrombotic Endocarditis (NBTE), is a rare and complex disease which challenges clinicians and researchers alike due to its multifactorial aetiology, diverse clinical presentations, and limited available treatment options. Here we report a case of marantic endocarditis with cerebral, renal and peripheral vascular infarctions in a 43-years-old lady with a KRAS G12C mutant adenocarcinoma of the lung who presented with a left sided 7 th CN palsy, left upper and lower limb hemiplegia, complete aphasia and fixed right gaze palsy. Initial imaging showed findings suggestive of a thrombotic CVA and a thrombectomy was carried out. She subsequently suffered a series of thromboembolic phenomena including several Janeway lesions and splinter haemorrhages, right lower lobe lung infarction, right renal infarction and multiple bilateral cerebral infarctions. Infective endocarditis was suspected and TTE (transthoracic echocardiogram) showed aortic valve vegetations. However, serial blood cultures were negative. An aortic valve replacement was carried out which confirmed NBTE. She was later started on Sotorasib in an attempt to offer palliative control of her pulmonary adenocarcinoma.</p> </p> <div class="alert alert-info text-left"><b>免责声明:</b> 此摘要通过人工智能工具翻译，尚未经过审核或验证</div> </div> </div>  <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">探索科技</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://chinese.scitechnol.com/author-guidelines.html" title="点击这里"> 作者指南</a></li> <li class="color-base"><a href="https://chinese.scitechnol.com/reviewer-guidelines.html" title="点击这里"> 审稿人指南</a></li> <li class="color-base"><a href="https://chinese.scitechnol.com/scitechnol-associations-indexing.html" title="点击这里"> 协会</a></li> <li class="color-base"><a href="https://chinese.scitechnol.com/submitmanuscript.html" title="点击这里"> 提交稿件</a></li> <li class="color-base"><a href="http://www.meetingsint.com/" title="点击这里" target="_blank"> 会议</a></li> 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