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class="vector-toc-numb">2</span> <span>Types of collectins</span> </div> </a> <ul id="toc-Types_of_collectins-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Function</span> </div> </a> <button aria-controls="toc-Function-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Function subsection</span> </button> <ul id="toc-Function-sublist" class="vector-toc-list"> <li id="toc-Aggregation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Aggregation"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Aggregation</span> </div> </a> <ul id="toc-Aggregation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Opsonization_and_activation_of_phagocytosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Opsonization_and_activation_of_phagocytosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Opsonization and activation of phagocytosis</span> </div> </a> <ul id="toc-Opsonization_and_activation_of_phagocytosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Inhibition_of_microbial_growth" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Inhibition_of_microbial_growth"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Inhibition of microbial growth</span> </div> </a> <ul id="toc-Inhibition_of_microbial_growth-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Modulation_of_inflammatory_responses" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Modulation_of_inflammatory_responses"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.4</span> <span>Modulation of inflammatory responses</span> </div> </a> <ul id="toc-Modulation_of_inflammatory_responses-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Modulation_of_the_adaptive_immune_system" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Modulation_of_the_adaptive_immune_system"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.5</span> <span>Modulation of the adaptive immune system</span> </div> </a> <ul id="toc-Modulation_of_the_adaptive_immune_system-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Modulation_of_allergic_response" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Modulation_of_allergic_response"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.6</span> <span>Modulation of allergic response</span> </div> </a> <ul id="toc-Modulation_of_allergic_response-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Apoptosis" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Apoptosis"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.7</span> <span>Apoptosis</span> </div> </a> <ul id="toc-Apoptosis-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Complement_activation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Complement_activation"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.8</span> <span>Complement activation</span> </div> </a> <ul id="toc-Complement_activation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Reviews" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reviews"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Reviews</span> </div> </a> <ul id="toc-Reviews-sublist" class="vector-toc-list"> </ul> </li> <li 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Spanish" lang="es" hreflang="es" data-title="Colectina" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D8%A7%D9%84%DA%A9%D8%AA%DB%8C%D9%86" title="کالکتین – Persian" lang="fa" hreflang="fa" data-title="کالکتین" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Collectine" title="Collectine – French" lang="fr" hreflang="fr" data-title="Collectine" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Kolektyny" title="Kolektyny – Polish" lang="pl" hreflang="pl" data-title="Kolektyny" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9A%D0%BE%D0%BB%D0%BB%D0%B5%D0%BA%D1%82%D0%B8%D0%BD" title="Коллектин – Russian" lang="ru" hreflang="ru" data-title="Коллектин" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E8%83%B6%E5%8E%9F%E5%87%9D%E9%9B%86%E7%B4%A0" title="胶原凝集素 – Chinese" lang="zh" hreflang="zh" data-title="胶原凝集素" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a 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class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Collectin&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Collectin&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q83167205" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button 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href="/wiki/Innate_immune_system" title="Innate immune system">innate immune system</a>. They form a family of collagenous Ca<sup>2+</sup>-dependent defense <a href="/wiki/Lectins" class="mw-redirect" title="Lectins">lectins</a>, which are found in animals. Collectins are soluble <a href="/wiki/Pattern_recognition_receptors" class="mw-redirect" title="Pattern recognition receptors">pattern recognition receptors</a> (PRRs). Their function is to bind to oligosaccharide structure or lipids that are on the surface of microorganisms. Like other PRRs they bind <a href="/wiki/Pathogen-associated_molecular_patterns" class="mw-redirect" title="Pathogen-associated molecular patterns">pathogen-associated molecular patterns</a> (PAMPs) and <a href="/wiki/Damage-associated_molecular_patterns" class="mw-redirect" title="Damage-associated molecular patterns">damage-associated molecular patterns</a> (DAMPs) of oligosaccharide origin. Binding of collectins to microorganisms may trigger elimination of microorganisms by <a href="/wiki/Platelet" title="Platelet">aggregation</a>, <a href="/wiki/Complement_system" title="Complement system">complement</a> activation, <a href="/wiki/Opsonization" class="mw-redirect" title="Opsonization">opsonization</a>, activation of <a href="/wiki/Phagocytosis" title="Phagocytosis">phagocytosis</a>, or inhibition of microbial growth. Other functions of collectins are modulation of <a href="/wiki/Inflammation" title="Inflammation">inflammatory</a>, <a href="/wiki/Allergic_response" title="Allergic response">allergic responses</a>, <a href="/wiki/Adaptive_immune_system" title="Adaptive immune system">adaptive immune system</a> and clearance of <a href="/wiki/Apoptosis" title="Apoptosis">apoptotic cells</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Functionally collectins are trimers. Monomeric subunit consists of four parts: </p> <ul><li>a <a href="/wiki/Cysteine" title="Cysteine">cysteine</a>-rich domain at the N-terminus</li> <li>a collagen-like domain</li> <li>a <a href="/wiki/Coiled-coil" class="mw-redirect" title="Coiled-coil">coiled-coil</a> neck domain</li> <li>a C-type lectin domain that is also called a <a href="/w/index.php?title=Carbohydrate_recognition_domain&action=edit&redlink=1" class="new" title="Carbohydrate recognition domain (page does not exist)">carbohydrate recognition domain</a> (CRD)</li></ul> <p>Recognition of specific parts of microorganism is mediated by CRD in presence of calcium.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Affinity of interaction between microbes and collectins depends on the degree of collectin oligomerization and also on the density of ligands on the surface of the microbe.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Types_of_collectins">Types of collectins</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=2" title="Edit section: Types of collectins"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nine types of collectins have been defined: </p> <ul><li>MBL = <a href="/wiki/Mannan-binding_lectin" title="Mannan-binding lectin">mannan-binding lectin</a> (mannose-binding lectin)</li> <li>SP-A = <a href="/wiki/Surfactant_protein_A" title="Surfactant protein A">surfactant protein A</a></li> <li>SP-D = <a href="/wiki/Surfactant_protein_D" title="Surfactant protein D">surfactant protein D</a></li> <li>CL-L1 = <a href="/wiki/Collectin_liver_1" class="mw-redirect" title="Collectin liver 1">collectin liver 1</a></li> <li>CL-P1 = <a href="/wiki/Collectin_placenta_1" class="mw-redirect" title="Collectin placenta 1">collectin placenta 1</a></li> <li>CL-43 = <a href="/wiki/Collectin_of_43_kDa" title="Collectin of 43 kDa">Collectin of 43 kDa</a></li> <li>CL-46 = <a href="/wiki/Collectin_of_46_kDa" title="Collectin of 46 kDa">collectin of 46 kDa</a></li> <li>CL-K1 = <a href="/w/index.php?title=Collectin_kidney_1&action=edit&redlink=1" class="new" title="Collectin kidney 1 (page does not exist)">collectin kidney 1</a></li> <li><a href="/wiki/Conglutinin" title="Conglutinin">Conglutinin</a><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li></ul> <p>CL-43, CL-46 and conglutinin are found in bovine. </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Aggregation">Aggregation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=4" title="Edit section: Aggregation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Collectins can bind to the surface of microorganisms and between carbohydrate ligands. Due to these properties, the interaction can result in aggregation.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Opsonization_and_activation_of_phagocytosis">Opsonization and activation of phagocytosis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=5" title="Edit section: Opsonization and activation of phagocytosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Collectins can act as opsonins. There is a specific interaction between collectins and receptors on phagocytic cells which can lead to increased clearance of microorganisms.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> MBL can bind to microorganisms and this interaction can lead to opsonization through complement activation,<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> or it can opsonize the microorganism directly.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> SP-A and SP-D can also interact with microorganisms and phagocytic cells to enhance phagocytosis of the microorganism.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Inhibition_of_microbial_growth">Inhibition of microbial growth</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=6" title="Edit section: Inhibition of microbial growth"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Collectins have effect on microorganism survival. SP-A and SP-D can bind to <a href="/wiki/Lipopolysaccharide" title="Lipopolysaccharide">LPS</a> (lipopolysaccharide) of both <a href="/wiki/Gram-negative" class="mw-redirect" title="Gram-negative">Gram-negative</a> and <a href="/wiki/Gram-positive" class="mw-redirect" title="Gram-positive">Gram-positive</a> bacteria. SP-A and SP-D can increase permeability of Gram-negative bacterial cell membrane.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Modulation_of_inflammatory_responses">Modulation of inflammatory responses</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=7" title="Edit section: Modulation of inflammatory responses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SP-A and SP-D can damp induction of inflammation by LPS or <a href="/wiki/Endotoxin" class="mw-redirect" title="Endotoxin">endotoxin</a>. It can be caused by removing the LPS or by binding the LPS to <a href="/wiki/CD14" title="CD14">CD14</a> receptor on <a href="/wiki/Macrophage" title="Macrophage">macrophages</a> that can block the inflammatory response.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> SP-A can also bind to <a href="/wiki/TLR2" class="mw-redirect" title="TLR2">TLR2</a> (toll-like receptor 2). This interaction causes decrease of <a href="/wiki/TNF-%CE%B1" class="mw-redirect" title="TNF-α">TNF-α</a> (tumor necrosis factor-α) production by alveolar macrophages stimulated with <a href="/wiki/Peptidoglycan" title="Peptidoglycan">peptidoglycan</a>.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> SP-A and SP-D can modulate cytokine production. They modulate the production of oxygen and nitrogen reactive species which are very important for phagocytic cells.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> SP-A and SP-D has s function as chemoattractants for alveolar <a href="/wiki/Neutrophil" title="Neutrophil">neutrophils</a> and <a href="/wiki/Monocyte" title="Monocyte">monocytes</a>.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> MBL can recognize peptidoglycan via <a href="/wiki/N-acetylglucosamine" class="mw-redirect" title="N-acetylglucosamine">N-acetylglucosamine</a>. This interaction leads to inhibition of ligand-induced inflammatory by macrophage chemokine production.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Modulation_of_the_adaptive_immune_system">Modulation of the adaptive immune system</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=8" title="Edit section: Modulation of the adaptive immune system"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SP-A and SP-D can suppress activated <a href="/wiki/T-lymphocyte" class="mw-redirect" title="T-lymphocyte">T-lymphocytes</a> and <a href="/wiki/Interleukin_2" title="Interleukin 2">IL-2</a> (interleukin-2) production.<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> SP-D increases bacterial <a href="/wiki/Antigen" title="Antigen">antigen</a> presentation by <a href="/wiki/Dendritic_cell" title="Dendritic cell">dendritic cells</a> <sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> whereas SP-A blocs differentation of the immature dendritic cells.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Modulation_of_allergic_response">Modulation of allergic response</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=9" title="Edit section: Modulation of allergic response"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Collectins SP-A and SP-D have anti-allergic effects: they inhibit <a href="/wiki/IgE" class="mw-redirect" title="IgE">IgE</a> binding to <a href="/wiki/Allergen" title="Allergen">allergens</a>, decrease <a href="/wiki/Histamine" title="Histamine">histamine</a> release from <a href="/wiki/Basophil" title="Basophil">basophils</a>, and inhibit T-lymphocyte production in the late phase of the inflammation.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Apoptosis">Apoptosis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=10" title="Edit section: Apoptosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Collectins SP-A and SP-D enhance clearance of apoptotic cells by macrophages.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Complement_activation">Complement activation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=11" title="Edit section: Complement activation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Collectins are linked with activation of lectin pathway of complement activation. At the beginning, there is a binding of collectin to PAMPs or DAMPs. Collectin MBL is involved in activation of the lectin complement pathway.<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> There are three serine proteases, MASP-1, 2 and 3 (<a href="/w/index.php?title=MBL-associated_serine_proteases&action=edit&redlink=1" class="new" title="MBL-associated serine proteases (page does not exist)">MBL-associated serine proteases</a>), which participate in activation of the lectin pathway. MASP-2 has a cleavage activity and it is essential for forming lectin C3 and C5 convertases and for activation of the complement.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reviews">Reviews</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=12" title="Edit section: Reviews"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>For more information and details see reviews:<sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Collectin&action=edit&section=13" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFWeisG_V_CrichlowH_M_MurthyW_A_Hendrickson1991" class="citation journal cs1">Weis, W I; G V Crichlow; H M Murthy; W A Hendrickson; K Drickamer (1991-11-05). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2954762-1">"Physical characterization and crystallization of the carbohydrate-recognition domain of a mannose-binding protein from rat"</a>. <i>The Journal of Biological Chemistry</i>. <b>266</b> (31): 20678–20686. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2954762-1">10.1016/S0021-9258(18)54762-1</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0021-9258">0021-9258</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1939118">1939118</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Physical+characterization+and+crystallization+of+the+carbohydrate-recognition+domain+of+a+mannose-binding+protein+from+rat&rft.volume=266&rft.issue=31&rft.pages=20678-20686&rft.date=1991-11-05&rft.issn=0021-9258&rft_id=info%3Apmid%2F1939118&rft_id=info%3Adoi%2F10.1016%2FS0021-9258%2818%2954762-1&rft.aulast=Weis&rft.aufirst=W+I&rft.au=G+V+Crichlow&rft.au=H+M+Murthy&rft.au=W+A+Hendrickson&rft.au=K+Drickamer&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0021-9258%252818%252954762-1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ACollectin" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWeisK_DrickamerW_A_Hendrickson1992" class="citation 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AntiqueWhite">Animal</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/C-type_lectin" title="C-type lectin">C-type lectins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Asialoglycoprotein_receptor" title="Asialoglycoprotein receptor">Asialoglycoprotein receptor</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">KLRD1</a></li> <li><a class="mw-selflink selflink">Collectin</a> <ul><li><a href="/wiki/Mannan-binding_lectin" title="Mannan-binding lectin">Mannan-binding lectin</a></li></ul></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">Mannose receptor</a></li> <li><i><a href="/wiki/Proteochondroitin_sulfate" class="mw-redirect" title="Proteochondroitin sulfate">proteochondroitin sulfate</a></i> <ul><li><a href="/wiki/Aggrecan" title="Aggrecan">Aggrecan</a></li> <li><a href="/wiki/Versican" title="Versican">Versican</a></li> <li><a href="/wiki/Brevican" title="Brevican">Brevican</a></li> <li><a href="/wiki/Neurocan" title="Neurocan">Neurocan</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/SIGLEC" class="mw-redirect" title="SIGLEC">SIGLEC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">Sialoadhesin</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/Myelin-associated_glycoprotein" title="Myelin-associated glycoprotein">Myelin-associated glycoprotein</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">SIGLEC5</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">SIGLEC6</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">SIGLEC7</a></li> <li><a href="/wiki/SIGLEC8" title="SIGLEC8">SIGLEC8</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">SIGLEC9</a></li> <li><a href="/wiki/SIGLEC10" title="SIGLEC10">SIGLEC10</a></li> <li><a href="/wiki/SIGLEC12" class="mw-redirect" title="SIGLEC12">SIGLEC12</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calnexin" title="Calnexin">Calnexin</a></li> <li><a href="/wiki/Calreticulin" title="Calreticulin">Calreticulin</a></li> <li><a href="/wiki/Galectin" title="Galectin">Galectin</a></li> <li><a href="/wiki/N-Acetylglucosamine_receptor" title="N-Acetylglucosamine receptor">N-Acetylglucosamine receptor</a></li> <li><a href="/wiki/Selectin" title="Selectin">Selectin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Plant</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Toxalbumin" title="Toxalbumin">Toxalbumins</a> <ul><li><a href="/wiki/Abrin" title="Abrin">Abrin</a></li> <li><a href="/wiki/Ricin" title="Ricin">Ricin</a></li></ul></li> <li><a href="/wiki/Mitogen" title="Mitogen">Mitogens</a> <ul><li><a href="/wiki/Concanavalin_A" title="Concanavalin A">Concanavalin A</a></li> <li><a href="/wiki/Phytohaemagglutinin" title="Phytohaemagglutinin">Phytohaemagglutinin</a></li> <li><a href="/wiki/Pokeweed_mitogen" title="Pokeweed mitogen">Pokeweed mitogen</a></li></ul></li> <li><a href="/wiki/Legume_lectin" title="Legume lectin">Legume lectin</a></li> <li><a href="/wiki/BanLec" title="BanLec">BanLec</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Innate_immune_system:_Pattern_recognition_receptors" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Pattern_recognition_receptors" title="Template:Pattern recognition receptors"><abbr title="View 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class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Toll-like_receptor" title="Toll-like receptor">Toll-like receptor</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">Mannose receptor</a></li> <li><a href="/wiki/Formyl_peptide_receptor" title="Formyl peptide receptor">Formyl peptide receptor</a></li> <li><a href="/wiki/Scavenger_receptor_(immunology)" title="Scavenger receptor (immunology)">Scavenger receptor</a></li> <li><a href="/wiki/Complement_receptor" title="Complement receptor">Complement receptor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Pattern_recognition_receptor#Cytoplasmic_PRRs" title="Pattern recognition receptor">Cytoplasmic_PRRs</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NOD-like_receptor" title="NOD-like receptor">NOD-like receptor</a></li> <li><a href="/wiki/RIG-I-like_receptor" title="RIG-I-like receptor">RIG-I-like receptor</a> <ul><li><a href="/wiki/RIG-I" title="RIG-I">RIG-I</a></li> <li><a href="/wiki/MDA5" title="MDA5">MDA5</a></li> <li><a href="/wiki/LGP2" title="LGP2">LGP2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Pattern_recognition_receptor#Secreted_PRRs" title="Pattern recognition receptor">Secreted_PRRs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Collectin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div 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