CINXE.COM

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independently of a change in the underlying DNA nucleotide sequence. Epigenetic modifications - including acetylation, methylation, phosphorylation, and ubiquitination amongst others - alter the accessibility of DNA to transcription machinery and therefore influence gene expression. Ongoing research is revealing the extent of the influence of epigenetics in disease states, and continues to provide a wealth of novel therapeutic targets.</p> <p>Find out more about <a href='https://www.novusbio.com/research-areas/epigenetics?utm_source=tocris.com&utm_medium=referral&utm_campaign=sister-link&utm_content=epigenetics' target='_blank'>Epigenetic modification detection methods and machinery</a> at our sister brand Novus Biologicals.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Targets</span></div> <div class="tab tab_4" data-tab="4" data-tabname="literature" id="pharm_tabs_literature"><span>Literature (6)</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="gene" id="pharm_tabs_gene"> <span>Molecular Machinery</span></div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_sub_cats"><h3>Epigenetics Target Files</h3><ul class="tile_column_1"><li><a href="/cell-biology/14-3-3-proteins" title="Browse products for 14.3.3 Proteins">14.3.3 Proteins</a></li><li><a href="/pharmacology/aurora-kinases" title="Browse products for Aurora Kinases">Aurora Kinases</a></li><li><a href="/cell-biology/bromodomains" title="Browse products for Bromodomains">Bromodomains</a></li><li><a href="/pharmacology/dna-methyltransferases" title="Browse products for DNA Methyltransferases">DNA Methyltransferases</a></li><li><a href="/pharmacology/histone-acetyltransferases" title="Browse products for Histone Acetyltransferases">Histone Acetyltransferases</a></li><li><a href="/pharmacology/histone-deacetylases" title="Browse products for Histone Deacetylases">Histone Deacetylases</a></li><li><a href="/pharmacology/histone-demethylases" title="Browse products for Histone Demethylases">Histone Demethylases</a></li><li><a href="/cell-biology/histone-peptides" title="Browse products for Histone Peptides">Histone Peptides</a></li><li><a href="/cell-biology/hypoxia-inducible-factors" title="Browse products for Hypoxia Inducible Factors (HIF)">Hypoxia Inducible Factors (HIF)</a></li><li><a href="/pharmacology/jak" title="Browse products for JAK">JAK</a></li></ul><ul class="tile_column_2"><li><a href="/pharmacology/lysine-methyltransferases" title="Browse products for Lysine Methyltransferases">Lysine Methyltransferases</a></li><li><a href="/cell-biology/mbt-domains" title="Browse products for MBT Domains">MBT Domains</a></li><li><a href="/pharmacology/pim-kinase" title="Browse products for Pim Kinase">Pim Kinase</a></li><li><a href="/pharmacology/poly-adp-ribose-glycohydrolase" title="Browse products for Poly(ADP-ribose) Glycohydrolase">Poly(ADP-ribose) Glycohydrolase</a></li><li><a href="/pharmacology/polyadp-ribose-polymerase" title="Browse products for Poly(ADP-ribose) Polymerase">Poly(ADP-ribose) Polymerase</a></li><li><a href="/pharmacology/protein-arginine-methyltransferases" title="Browse products for Protein Arginine Methyltransferases">Protein Arginine Methyltransferases</a></li><li><a href="/pharmacology/protein-ser-and-thr-phosphatases" title="Browse products for Protein Ser/Thr Phosphatases">Protein Ser/Thr Phosphatases</a></li><li><a href="/pharmacology/protein-tyrosine-phosphatases" title="Browse products for Protein Tyrosine Phosphatases">Protein Tyrosine Phosphatases</a></li><li><a href="/pharmacology/rna-polymerase" title="Browse products for RNA Polymerase">RNA Polymerase</a></li></ul></div> <div class="pharm_rel_cats"><h3>Related Targets</h3><ul class="tile_column_1"><li><a href="/product-type/tocriscreen-compound-libraries" title="Browse products for Tocriscreen™ Compound Libraries">Tocriscreen™ Compound Libraries</a></li></ul><ul class="tile_column_2"></ul></div> <div class="pharm_long_desc"><p>Epigenetic mechanisms integrate environmental changes at the cellular level and enable cellular plasticity. As a result, they are involved in pathologies related to diet, lifestyle and environmental exposure to toxins, including <a href='/research-area/cancer-research'title='Browse products for Cancer Research'>cancer</a>, <a href='/research-area/pain-and-inflammation-research'title='Browse products for Pain & Inflammation Research'>inflammation</a> and <a href='/research-area/endocrinology-research' title='Browse products for Endocrinology Research'>metabolic disorders</a>. Proteins that carry out these epigenetic modifications can be thought of as being either "<a href='/cell-biology/epigenetic-writers' title='View more information about Epigenetic writers'>writers</a>", "<a href='/cell-biology/epigenetic-readers' title='View more information about Epigenetic readers'>readers</a>" or "<a href='/cell-biology/epigenetic-erasers' title='View more information about Epigenetic erasers'>erasers</a>".</p> <h5><a href='/cell-biology/epigenetic-writers' title='View more information about Epigenetic writers'>Epigenetic Writers »</a></h5> <p class='pRel'>Epigenetic writers catalyze the addition of chemical groups onto either histone tails or the DNA itself. These modifications are known as epigenetic marks. <a href='/cell-biology/epigenetic-writers' title='View more information about Epigenetic writers' class='redBdLnk moreInfo'>More Information »</a></p> <h5><a href='/cell-biology/epigenetic-readers' title='View more information about Epigenetic readers'>Epigenetic Readers »</a></h5> <p class='pRel'>Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks. "Writer" and "eraser" enzymes may also contain such reader domains, leading to the coordination of "read-write" or "read-erase" mechanisms. <a href='/cell-biology/epigenetic-readers' title='View more information about Epigenetic readers' class='redBdLnk moreInfo'>More Information »</a></p> <h5><a href='/cell-biology/epigenetic-erasers' title='View more information about Epigenetic erasers'>Epigenetic Erasers »</a></h5> <p class='pRel'>Epigenetic marks are not necessarily permanent modifications; instead, they can be removed by a group of enzymes known as "erasers" in order to reverse the influence of a given epigenetic mark on gene expression. <a href='/cell-biology/epigenetic-erasers' title='View more information about Epigenetic erasers' class='redBdLnk moreInfo'>More Information »</a></p> <hr> <h3>Resources for Epigenetics Research</h3> <div class='row'> <div class='col-sm-12 col-md-6'> <h4>Blog Post: Developing Epigenetic Chemical Probes</h4> <p>Written by Dr Suzanne Ackloo, this blog details the development of chemical probes for epigenetic targets at the Structural Genomics Consortium (SGC). Dr Ackloo describes the mission of the SCG and how they go about achieving their goals, as well as describing notable successes of the project.</p> <a href='/resources/tocris-blog/developing-chemical-probes-epigenetic-targets' title='Read the blog post' class='btn btn-quinary'>Read Now!</a> </div> <div class='col-sm-12 col-md-6 text-center'> <a href='/resources/tocris-blog/developing-chemical-probes-epigenetic-targets' title='Read the blog post'><img src='https://resources.tocris.com/images/blog/developing-chemical-probes-bucket.png' alt='Blog Post - Developing Epigenetic Chemical Probes'></a> </div> </div> <hr> <div class='row'> <div class='col-sm-12 col-md-6'> <h4>Blog Post: Application of Epigenetic Probes in Non-Oncology Research </h4> <p>Epigenetic chemical probes have well established uses in oncology research. This blog post, written by Dr Suzanne Ackloo from the SGC, summarizes the role of bromodomains and epigenetic enzymes in research outside the oncology field.</p> <a href='/resources/tocris-blog/applications-epigenetic-chemical-probes-non-oncology-research' title='Read the blog post' class='btn btn-quinary'>Read Now!</a> </div> <div class='col-sm-12 col-md-6 text-center'> <a href='/resources/tocris-blog/applications-epigenetic-chemical-probes-non-oncology-research' title='Read the blog post'><img src='https://resources.tocris.com/images/blog/epigenetics-probes-non-oncology-research-bucket.png' alt='Blog Post - epigenetic probes in non-oncology research'></a> </div> </div></div> </div> <div class="tab_content tab_2" data-tab="2"> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> <h3>Literature for Epigenetics</h3><p>Tocris offers the following scientific literature for Epigenetics to showcase our products. We invite you to request* your copy today!</p><p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p><hr/><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/product-guides/fullsize/814154.jpg?v=2" data-toggle="lightbox" data-title="Epigenetics in Cancer Research Product Guide" data-footer="<a href='/literature/literature-request/814154' rel='nofollow' title='Request copy of the Epigenetics in Cancer'>Request copy</a> or <a href='/literature/literature-request/p814154' rel='nofollow' title='Request PDF of the Epigenetics in Cancer'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/814154.jpg?v=2" alt="Epigenetics in Cancer Research Product Guide" class="img-fluid"></a></div> <h4>Epigenetics in Cancer Research Product Guide</h4> <p>This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:</p> <ul class='bullet_list'> <li>Histone Methylation</li> <li>Histone Acetylation</li> <li>DNA Methylation</li> <li>Ubiquitination</li> <li>Bromodomains</li> </ul> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/814154" rel="nofollow" title="Request copy of the Epigenetics in Cancer Research Product Guide">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p814154" rel="nofollow" title="Request PDF of the Epigenetics in Cancer Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/product-guides" title="View all Product Guides & Listings">View all Product Guides & Listings</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/product-guides/fullsize/683696.jpg?v=4" data-toggle="lightbox" data-title="Stem Cell Research Product Guide" data-footer="<a href='/literature/literature-request/683696' rel='nofollow' title='Request copy of the Stem Cell'>Request copy</a> or <a href='/literature/literature-request/p683696' rel='nofollow' title='Request PDF of the Stem Cell'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/683696.jpg?v=4" alt="Stem Cell Research Product Guide" class="img-fluid"></a></div> <h4>Stem Cell Research Product Guide</h4> <p>This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:</p> <ul class='bullet_list'> <li>Self-renewal and Maintenance</li> <li>Differentiation</li> <li>Reprogramming</li> <li>Organoid Generation</li> <li>GMP and Ancillary Material Grade Products </li> </ul> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/683696" rel="nofollow" title="Request copy of the Stem Cell Research Product Guide">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p683696" rel="nofollow" title="Request PDF of the Stem Cell Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/product-guides" title="View all Product Guides & Listings">View all Product Guides & Listings</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/reviews/fullsize/417572.jpg?v=2" data-toggle="lightbox" data-title="Epigenetics Scientific Review" data-footer="<a href='/literature/literature-request/417572' rel='nofollow' title='Request copy of the Epigenetics'>Request copy</a> or <a href='/literature/literature-request/p417572' rel='nofollow' title='Request PDF of the Epigenetics'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/reviews/regular/417572.jpg?v=2" alt="Epigenetics Scientific Review" class="img-fluid"></a></div> <h4>Epigenetics Scientific Review</h4> <p>Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/417572" rel="nofollow" title="Request copy of the Epigenetics Scientific Review">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p417572" rel="nofollow" title="Request PDF of the Epigenetics Scientific Review">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/scientific-reviews" title="View all Scientific Reviews">View all Scientific Reviews</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/508457.jpg?v=2" data-toggle="lightbox" data-title="Cell Cycle & DNA Damage Repair Poster" data-footer="<a href='/literature/literature-request/508457' rel='nofollow' title='Request copy of the Cell Cycle & DNA Damage Repair'>Request copy</a> or <a class=' pdf-download' href='https://resources.tocris.com/pdfs/literature/posters/cell-cycle-dna-poster-2023.pdf' download='https://resources.tocris.com/pdfs/literature/posters/cell-cycle-dna-poster-2023.pdf' rel='nofollow' title='Download PDF of the Cell Cycle & DNA Damage Repair' data-title='Cell Cycle & DNA Damage Repair Poster'>Download PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/508457.jpg?v=2" alt="Cell Cycle & DNA Damage Repair Poster" class="img-fluid"></a></div> <h4>Cell Cycle & DNA Damage Repair Poster</h4> <p>In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. 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It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/508457" rel="nofollow" title="Request copy of the Cell Cycle & DNA Damage Repair Poster">Request copy</a> </li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/cell-cycle-dna-poster-2023.pdf" download="https://resources.tocris.com/pdfs/literature/posters/cell-cycle-dna-poster-2023.pdf" rel="nofollow" target="_blank" title="Download PDF of the Cell Cycle & DNA Damage Repair Poster" data-title="Cell Cycle & DNA Damage Repair Poster">Download PDF<div class="lit_pdf"></div></a></li> <li><a class="btn btn-quinary" href="/literature/life-science-posters" title="View all Life Science Posters">View all Life Science Posters</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/482945.jpg?v=2" data-toggle="lightbox" data-title="Epigenetics in Cancer Poster" data-footer="<a href='/literature/literature-request/482945' rel='nofollow' title='Request copy of the Epigenetics in Cancer'>Request copy</a> or <a class=' pdf-download' href='https://resources.tocris.com/pdfs/literature/posters/epigenetics-cancer-poster-2023.pdf' download='https://resources.tocris.com/pdfs/literature/posters/epigenetics-cancer-poster-2023.pdf' rel='nofollow' title='Download PDF of the Epigenetics in Cancer' data-title='Epigenetics in Cancer Poster'>Download PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/482945.jpg?v=2" alt="Epigenetics in Cancer Poster" class="img-fluid"></a></div> <h4>Epigenetics in Cancer Poster</h4> <p>This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/482945" rel="nofollow" title="Request copy of the Epigenetics in Cancer Poster">Request copy</a> </li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/epigenetics-cancer-poster-2023.pdf" download="https://resources.tocris.com/pdfs/literature/posters/epigenetics-cancer-poster-2023.pdf" rel="nofollow" target="_blank" title="Download PDF of the Epigenetics in Cancer Poster" data-title="Epigenetics in Cancer Poster">Download PDF<div class="lit_pdf"></div></a></li> <li><a class="btn btn-quinary" href="/literature/life-science-posters" title="View all Life Science Posters">View all Life Science Posters</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/posters/fullsize/522525.jpg" data-toggle="lightbox" data-title="Rheumatoid Arthritis Poster" data-footer="<a href='/literature/literature-request/522525' rel='nofollow' title='Request copy of the Rheumatoid Arthritis'>Request copy</a> or <a class=' pdf-download' href='https://resources.tocris.com/pdfs/literature/posters/rheumatoide-arthritis-poster-2016.pdf' download='https://resources.tocris.com/pdfs/literature/posters/rheumatoide-arthritis-poster-2016.pdf' rel='nofollow' title='Download PDF of the Rheumatoid Arthritis' data-title='Rheumatoid Arthritis Poster'>Download PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/522525.jpg" alt="Rheumatoid Arthritis Poster" class="img-fluid"></a></div> <h4>Rheumatoid Arthritis Poster</h4> <p>Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/522525" rel="nofollow" title="Request copy of the Rheumatoid Arthritis Poster">Request copy</a> </li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/rheumatoide-arthritis-poster-2016.pdf" download="https://resources.tocris.com/pdfs/literature/posters/rheumatoide-arthritis-poster-2016.pdf" rel="nofollow" target="_blank" title="Download PDF of the Rheumatoid Arthritis Poster" data-title="Rheumatoid Arthritis Poster">Download PDF<div class="lit_pdf"></div></a></li> <li><a class="btn btn-quinary" href="/literature/life-science-posters" title="View all Life Science Posters">View all Life Science Posters</a></li> </ul> </div></div> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> <H3>Epigenetics: Molecular Machinery</H3> <table class="table table-responsive"> <tr> <th style='width:25%'> Epigenetic Mechanism </th> <th style='width:25%'> "Writer" Enzymes </th> <th style='width:25%'> "Reader" Domains </th> <th style='width:25%'> "Eraser" Enzymes </th> </tr> <tr> <td class='pb_bld' style='width:25%'> DNA Methylation </td> <td style='width:25%'> DNA Methyltransferases </td> <td style='width:25%'> Methyl-CpG Binding Domains </td> <td style='width:25%'> Active DNA Demethylation Enzymes; Passive DNA Demethylation </td> </tr> <tr> <td class='pb_bld'> Histone Acetylation </td> <td> Histone Acetyltransferases </td> <td> Bromodomains; Tandem PHD Fingers; Pleckstrin Homology Domains </td> <td> Histone Deacetylases </td> </tr> <tr> <td class='pb_bld'> Histone Arginine Methylation </td> <td> Protein Arginine Methyltransferases (PRMTs) </td> <td> Tudor Domains (recognize symmetrically dimethylated arginines); WD40 Domains </td> <td> Histone Demethylases (JMJD6); Peptidyl Arginine Deiminases (putative) </td> </tr> <tr> <td class='pb_bld'> Histone Lysine Methylation </td> <td> Histone Lysine Methyltransferases </td> <td> Chromodomains; Tudor Domains; PHD Fingers; MBT Domains; ZF-CW Proteins; WD40 Domains; PWWP </td> <td> Histone Lysine Demethylases </td> </tr> <tr> <td class='pb_bld'> Histone Phosphorylation </td> <td> Kinases (JAK2, ATM/ATR, PKC, PKA, Haspin, Aurora B Kinase, RSK2, AMPK, MSK, MEK) </td> <td> Chromoshadow Domains (phosphoTyrosine); 14.3.3 Proteins (phosphoSerine); BIR Domains; BRCT Proteins </td> <td> Protein Serine/Threonine Phosphatases; Protein Tyrosine Phosphatases </td> </tr> <tr> <td class='pb_bld'> Histone Ubiquitination </td> <td> Ubiquitin E2 Conjugases; Ubiquitin E3 Ligases </td> <td> Unknown </td> <td> Deubiquitinating Enzymes </td> </tr> </table> <h3>Acronyms</h3> <strong>AMPK</strong> - Adenosine monophosphate-activated kinase; <strong>ATM</strong> - Ataxia telangiectasia mutated; <strong>ATR</strong> - Ataxia telangiectasia and RAD3 related; <strong>BIR</strong> - Baculovirus inhibitor of apoptosis protein repeat; <strong>BRCT</strong> - Breast cancer type 1 susceptibility protein C terminus; <strong>JAK2</strong> - Janus kinase 2; <strong>JMJD6</strong> - Jumonji domain-containing 6 protein; <strong>MBT</strong> - Malignant brain tumor; <strong>MEK</strong> - Mitogen-activated protein kinase kinase; <strong>MSK</strong> - Mitogen- and stress-activated kinase; <strong>PHD</strong> - Plant homeodomain; <strong>PKA</strong> - Protein kinase A; <strong>PKC</strong> - Protein kinase C; <strong>PWWP</strong> - Proline-Tryptophan-Tryptophan-Proline; <strong>RSK2</strong> - Ribosomal S6 kinase C; <strong>ZF-CW</strong> - Zinc Finger CW </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like peptide-1 receptor <br />(GLP1-R) positive allosteric modulator</div> <div class="fp_featured_product"><a href="/products/chir-99021-in-solution_8170">8170 | CHIR 99021 in solution</a><br /> Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO</div> <div class="fp_featured_product"><a href="/products/bi-3231_8039">8039 | BI 3231</a><br /> Potent and selective hydroxysteroid 17尾 dehydrogenase 13 (HSD17B13) inhibitor</div> </div> </div> </div> <div class="distributor_region"></div> <div class="widget"> <div class="widget_title">Literature in this Area</div> <div class="widget_content carousel slide" id="ds_literature_scroller" data-ride="carousel" data-interval="8000">  <div class="carousel-inner"><div class="item active"><div class="highlight">Epigenetics in Cancer Guide</div> <a href="/literature/product-guides/epigenetics-in-cancer"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/814154.jpg?v=2" alt="Epigenetics in Cancer Research Product Guide"></a><p class="small">Our product guide reviews some of the main areas in cancer epigenetic research and highlights products that can be used for the main epigenetic targets.</p><a class="btn btn-quinary" href="/literature/literature-request/814154" rel="nofollow" title="Request copy of the Epigenetics in Cancer Research Product Guide">Request copy</a><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p814154" rel="nofollow" title="Request PDF of the Epigenetics in Cancer Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a></div><div class="item"><div class="highlight">Stem Cell Research Product Guide</div> <a href="/literature/product-guides/stem-cell"><img loading="lazy" src="https://resources.tocris.com/images/literature/product-guides/regular/683696.jpg?v=4" alt="Stem Cell Research Product Guide"></a><p class="small">Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products.</p><a class="btn btn-quinary" href="/literature/literature-request/683696" rel="nofollow" title="Request copy of the Stem Cell Research Product Guide">Request copy</a><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p683696" rel="nofollow" title="Request PDF of the Stem Cell Research Product Guide">Request PDF<div class="lit_request_pdf"></div></a></div><div class="item"><div class="highlight">Epigenetics Scientific Review</div> <a href="/literature/scientific-reviews/epigenetics"><img loading="lazy" src="https://resources.tocris.com/images/literature/reviews/regular/417572.jpg?v=2" alt="Epigenetics Scientific Review"></a><p class="small">Our Epigenetics review gives an overview of the development of chemical probes for epigenetic targets, and discusses their biological effects.</p><a class="btn btn-quinary" href="/literature/literature-request/417572" rel="nofollow" title="Request copy of the Epigenetics Scientific Review">Request copy</a><a class="btn btn-quinary request-pdf" href="/literature/literature-request/p417572" rel="nofollow" title="Request PDF of the Epigenetics Scientific Review">Request PDF<div class="lit_request_pdf"></div></a></div><div class="item"><div class="highlight">Cell Cycle Life Science Poster</div> <a href="/literature/life-science-posters/cell-cycle-and-dna-damage-repair"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/508457.jpg?v=2" alt="Cell Cycle & DNA Damage Repair Poster"></a><p class="small">Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.</p><a class="btn btn-quinary" href="/literature/literature-request/508457" rel="nofollow" title="Request copy of the Cell Cycle & DNA Damage Repair Poster">Request copy</a><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/cell-cycle-dna-poster-2023.pdf" download="https://resources.tocris.com/pdfs/literature/posters/cell-cycle-dna-poster-2023.pdf" rel="nofollow" target="_blank" title="Download PDF of the Cell Cycle & DNA Damage Repair Poster" data-title="Cell Cycle & DNA Damage Repair Poster">Download PDF<div class="lit_pdf"></div></a></div><div class="item"><div class="highlight">Epigenetics in Cancer Life Science Poster</div><h5>Taken from the Cancer Product Guide Edition 3</h5> <a href="/literature/life-science-posters/epigenetics-in-cancer"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/482945.jpg?v=2" alt="Epigenetics in Cancer Poster"></a><p class="small">Our Epigenetics in Cancer poster summarizes the main epigenetic targets in cancer, and highlights chemical compounds for the inhibition of these targets.</p><a class="btn btn-quinary" href="/literature/literature-request/482945" rel="nofollow" title="Request copy of the Epigenetics in Cancer Poster">Request copy</a><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/epigenetics-cancer-poster-2023.pdf" download="https://resources.tocris.com/pdfs/literature/posters/epigenetics-cancer-poster-2023.pdf" rel="nofollow" target="_blank" title="Download PDF of the Epigenetics in Cancer Poster" data-title="Epigenetics in Cancer Poster">Download PDF<div class="lit_pdf"></div></a></div><div class="item"><div class="highlight">Rheumatoid Arthritis Life Science Poster</div><h5>Written by Adam P. Cribbs <em>et al.</em></h5> <a href="/literature/life-science-posters/rheumatoid-arthritis"><img loading="lazy" src="https://resources.tocris.com/images/literature/posters/regular/522525.jpg" alt="Rheumatoid Arthritis Poster"></a><p class="small">Our Rheumatoid Arthritis poster summarizes the disease pathology and highlights some of the epigenetic modifications associated with the condition.</p><a class="btn btn-quinary" href="/literature/literature-request/522525" rel="nofollow" title="Request copy of the Rheumatoid Arthritis Poster">Request copy</a><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pdfs/literature/posters/rheumatoide-arthritis-poster-2016.pdf" download="https://resources.tocris.com/pdfs/literature/posters/rheumatoide-arthritis-poster-2016.pdf" rel="nofollow" target="_blank" title="Download PDF of the Rheumatoid Arthritis Poster" data-title="Rheumatoid Arthritis Poster">Download PDF<div class="lit_pdf"></div></a></div></div>  <a class="left 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